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Search of human proteins with 23943920
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23943920 cytosolic phospholipase A2, group IVA [Homo
sapiens]
(749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] 1523 0.0
gi|67972429 phospholipase A2, group IVF [Homo sapiens] 300 3e-81
gi|122937428 phospholipase A2, group 4E [Homo sapiens] 291 1e-78
gi|116174754 phospholipase A2, group IVD [Homo sapiens] 256 4e-68
gi|167860120 phospholipase A2, group IVB [Homo sapiens] 241 2e-63
gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens] 241 2e-63
gi|226693363 phospholipase A2, group IVC isoform 3 [Homo sapiens] 167 4e-41
gi|226693357 phospholipase A2, group IVC isoform 2 precursor [Ho... 167 4e-41
gi|226693354 phospholipase A2, group IVC isoform 1 precursor [Ho... 167 4e-41
gi|19718759 myoferlin isoform b [Homo sapiens] 49 2e-05
gi|7305053 myoferlin isoform a [Homo sapiens] 49 2e-05
gi|103472031 family with sequence similarity 62 (C2 domain conta... 45 2e-04
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 44 5e-04
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 44 5e-04
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 44 5e-04
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 44 5e-04
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 43 0.001
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 43 0.001
gi|4506067 protein kinase C, alpha [Homo sapiens] 42 0.002
gi|13384594 protein kinase C, gamma [Homo sapiens] 42 0.002
gi|21361472 neural precursor cell expressed, developmentally dow... 41 0.004
gi|222352090 neural precursor cell expressed, developmentally do... 41 0.004
gi|222352088 neural precursor cell expressed, developmentally do... 41 0.004
gi|222352086 neural precursor cell expressed, developmentally do... 41 0.004
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 41 0.004
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 41 0.004
gi|39752671 synaptotagmin X [Homo sapiens] 40 0.006
gi|211059429 synaptotagmin II [Homo sapiens] 39 0.018
gi|31543670 synaptotagmin II [Homo sapiens] 39 0.018
gi|24308219 synaptotagmin IV [Homo sapiens] 39 0.018
>gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]
Length = 749
Score = 1523 bits (3942), Expect = 0.0
Identities = 749/749 (100%), Positives = 749/749 (100%)
Query: 1 MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT 60
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
Sbjct: 1 MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT 60
Query: 61 RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV 120
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
Sbjct: 61 RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV 120
Query: 121 PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG 180
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
Sbjct: 121 PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG 180
Query: 181 LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH 240
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
Sbjct: 181 LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH 240
Query: 241 PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG 300
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
Sbjct: 241 PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG 300
Query: 301 ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG 360
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
Sbjct: 301 ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG 360
Query: 361 TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE 420
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
Sbjct: 361 TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE 420
Query: 421 LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN 480
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
Sbjct: 421 LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN 480
Query: 481 TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV 540
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
Sbjct: 481 TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV 540
Query: 541 KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN 600
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
Sbjct: 541 KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN 600
Query: 601 KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE 660
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE
Sbjct: 601 KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETE 660
Query: 661 EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR 720
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
Sbjct: 661 EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR 720
Query: 721 QNPSRCSVSLSNVEARRFFNKEFLSKPKA 749
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
Sbjct: 721 QNPSRCSVSLSNVEARRFFNKEFLSKPKA 749
>gi|67972429 phospholipase A2, group IVF [Homo sapiens]
Length = 849
Score = 300 bits (768), Expect = 3e-81
Identities = 210/656 (32%), Positives = 332/656 (50%), Gaps = 70/656 (10%)
Query: 74 TFEFILDPNQENVLEITLMDANYVMDE-----------TLGTATFTVSSMKVGEKKEVPF 122
TF F ++P + L + LM+ + LG +SS+ +G++++
Sbjct: 232 TFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSV 291
Query: 123 IFNQVTEMVLEMSLEVCSCP-DLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGL 181
+ E+ L M +E+ S DLR L D E+ F +RK+ + ++++++LG SE L
Sbjct: 292 ALGEGQEVALSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVVSKALQQVLGL--SEAL 349
Query: 182 HSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHP 241
S + VPVVA+LGSGGG RAM G + L E G+LD TY++G+SGSTW +STLY P
Sbjct: 350 DSGQ-VPVVAVLGSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVSGSTWCISTLYRDP 408
Query: 242 DFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGE 301
+ + + E +V + + L+ ++++ Y + L ++ SG V+ D++G+L+
Sbjct: 409 AWSQVALQGPIERAQVHVCSSKMGALSTERLQYYTQELGVRERSGHSVSLIDLWGLLVEY 468
Query: 302 TLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGT 361
L LS +E V Q P P++T ++V+ ++S FA+W EF+PYE+G KYG
Sbjct: 469 LLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVRTNLSGEDFAEWCEFTPYEVGFPKYGA 528
Query: 362 FMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRV-LGVSGSQSRGSTMEEE 420
++ +LFGS+ FMG +++ E + +L G+WGSAF+ + + L +GS
Sbjct: 529 YVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFATSLDEIFLKTAGSGLSFLEWYRG 588
Query: 421 LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMI--MALVSDSAL 478
NIT D+ +P Q N + R++ S + L
Sbjct: 589 SVNIT-------------DDCQKP------------QLHNPSRLRTRLLTPQGPFSQAVL 623
Query: 479 -FNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEP 537
T + + NF GL L+ Y ++ A +D+ PD F P
Sbjct: 624 DIFTSRFTSAQSFNFTRGLCLHKDY-VAGREFVAWKDT-----------HPDAFPNQLTP 671
Query: 538 LDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWA 597
+ +++VD G N P+PL L PQR VDLI+SFD+S PF+ L + EK+
Sbjct: 672 M---RDCLYLVDGGFAINSPFPLALLPQRAVDLILSFDYSL-----EAPFEVLKMTEKYC 723
Query: 598 KMNKLPFPKIDPYVFDREGLKECYVF-KPKNPDMEKDCPTIIHFVLANINFRKYKAPGVP 656
+PFP I+ D E +ECY+F K ++P P ++HF L N FR + APGV
Sbjct: 724 LDRGIPFPSIEVGPEDVEEARECYLFAKAEDP----RSPIVLHFPLVNRTFRTHLAPGVE 779
Query: 657 RETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAM 712
R+T EEK DF + + P++P+ NF Y Q F RL L +N LNN++ +K A+
Sbjct: 780 RQTAEEKAFGDF-VINRPDTPYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCAL 834
Score = 63.9 bits (154), Expect = 5e-10
Identities = 43/123 (34%), Positives = 63/123 (51%), Gaps = 5/123 (4%)
Query: 22 VVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDP 81
V VLRAT + +G D+L D YV+L++ T S +TR N +P WNETF + +
Sbjct: 48 VKVLRATNI-RGT--DLLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQIHG 104
Query: 82 NQENVLEITLMDANYVMDETLGTATFTVSSMKVGE--KKEVPFIFNQVTEMVLEMSLEVC 139
+NVLE+TL D + + + L F + S+K G+ K P E+ +E LE
Sbjct: 105 AVKNVLELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKS 164
Query: 140 SCP 142
P
Sbjct: 165 QVP 167
>gi|122937428 phospholipase A2, group 4E [Homo sapiens]
Length = 839
Score = 291 bits (746), Expect = 1e-78
Identities = 192/597 (32%), Positives = 310/597 (51%), Gaps = 50/597 (8%)
Query: 133 EMSLEVCSCP---DLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPV 189
E+ ++ CP D+R +LC E F Q+RK + +++K++L + E L +VP+
Sbjct: 288 ELHMKSTPCPETLDVRLGFSLCPAELEFLQKRKVVVAKALKQVL--QLEEDLQED-EVPL 344
Query: 190 VAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPE 249
+AI+ +GGG R+M G + L + +LDCA+Y+ GLSG+TW M+TLY PD+ K E
Sbjct: 345 IAIMATGGGTRSMTSMYGHLLGLQKLNLLDCASYITGLSGATWTMATLYRDPDWSSKNLE 404
Query: 250 EINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMN 309
E ++V + L L P +++++ E L ++ G VTFTD +G+LI L R
Sbjct: 405 PAIFEARRHVVKDKLPSLFPDQLRKFQEELRQRSQEGYRVTFTDFWGLLIETCLGDERNE 464
Query: 310 TTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFG 369
LS + ++ Q PLP++ ++VK DVS F +W EFSPYE+G+ KYG F+ +LFG
Sbjct: 465 CKLSDQRAALSCGQNPLPIYLTINVKDDVSNQDFREWFEFSPYEVGLQKYGAFIPSELFG 524
Query: 370 SKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHI 429
S+FFMG +VK+ E+ + +++G+W S FS L + + + T EE T + +
Sbjct: 525 SEFFMGRLVKRIPESRICYMLGLWSSIFS------LNLLDAWNLSHTSEEFFHRWTREKV 578
Query: 430 VSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKV 489
D +DE P+ + + + SW+ ++ T +
Sbjct: 579 -----QDIEDEPILPEIPKCDANILETTVVIPGSWLSNSFREIL-------THRSFVSEF 626
Query: 490 HNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVD 549
HNF+ GL L+T+Y + + D LD P++ L + + ++D
Sbjct: 627 HNFLSGLQLHTNYLQN-----GQFSRWKDTVLDGF---PNQ-------LTESANHLCLLD 671
Query: 550 SGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDP 609
+ N YP +LRP+R DLII ++ A + P K+ ++ + +PFPK +
Sbjct: 672 TAFFVNSSYPPLLRPERKADLIIHLNYCA--GSQTKPLKQTC---EYCTVQNIPFPKYE- 725
Query: 610 YVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETEEEKEIADFD 669
+ E LKECY+ +NP E D P + F L N FRKYKAPGV R + EE E D
Sbjct: 726 LPDENENLKECYLM--ENP-QEPDAPIVTFFPLINDTFRKYKAPGVER-SPEELEQGQVD 781
Query: 670 IFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRC 726
I+ P++P++T Y F +L L +N LNN D + +A+ ++E +++ +C
Sbjct: 782 IY-GPKTPYATKELTYTEATFDKLVKLSEYNILNNKDTLLQALRLAVEKKKRLKGQC 837
Score = 57.0 bits (136), Expect = 6e-08
Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 9/140 (6%)
Query: 43 DPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVM-DET 101
D +V L++ T + RTR +N NP WNE+F F + +NVLE+++ D + V D+
Sbjct: 61 DCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQIQSRVKNVLELSVCDEDTVTPDDH 120
Query: 102 LGTATFTVSSMKVGEKKEVPFIFNQ--VTEMVLEMSLEVCSCP--DLRFSMALCDQE--- 154
L T + ++ + +K V F N + E+ +E LE P L + L ++
Sbjct: 121 LLTVLYDLTKLCFRKKTHVKFPLNPQGMEELEVEFLLEESPSPPETLVTNGVLVSRQVSC 180
Query: 155 -KTFRQQRKEHIRESMKKLL 173
+ Q R+ RE MK LL
Sbjct: 181 LEVHAQSRRRRKREKMKDLL 200
>gi|116174754 phospholipase A2, group IVD [Homo sapiens]
Length = 818
Score = 256 bits (655), Expect = 4e-68
Identities = 183/627 (29%), Positives = 310/627 (49%), Gaps = 59/627 (9%)
Query: 99 DETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPD---LRFSMALCDQEK 155
D + G T + + +G KEV + + L+ CP+ + LC +E+
Sbjct: 234 DNSAGYLTVPLRPLTIG--KEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQ 291
Query: 156 TFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYES 215
F +RK+ + +++K+ L +VPVV I+ +GGG RAM G + AL +
Sbjct: 292 AFLSRRKQVVAKALKQALQLDRDL---QEDEVPVVGIMATGGGARAMTSLYGHLLALQKL 348
Query: 216 GILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRY 275
G+LDC TY +G+SGSTW M+ LY P++ ++ E ++++ + L + +P+++ Y
Sbjct: 349 GLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASY 408
Query: 276 VESLWKKKSSGQPVTFTDIFGMLIGETLIHNR-MNTTLSSLKEKVNTAQCPLPLFTCLHV 334
L + G P TF D++ +++ E+++H + M+ LS + + Q PLPL+ L+V
Sbjct: 409 RRELELRAEQGHPTTFVDLWALVL-ESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNV 467
Query: 335 KP-DVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVW 393
K ++ L F +WVEFSPYE+G KYG F+ P+LFGS+FFMG ++++ E + FL +W
Sbjct: 468 KENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIW 527
Query: 394 GSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAG 453
+ FS+ N + S G + ++ +++ T EP T
Sbjct: 528 SNIFSL--NLLDAWYDLTSSGESWKQHIKDKTR------------SLEKEPLTT------ 567
Query: 454 SDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQ 513
S S +ASW+ + AL F T + NF+ GL L+ Y DF+T
Sbjct: 568 SGTSSRLEASWL-QPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDY--CSHKDFSTW 624
Query: 514 DSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIIS 573
+ D + + L K ++ +VD+ N P + RP R +DLI+S
Sbjct: 625 ADYQLDSMPS-------------QLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILS 671
Query: 574 FDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK-PKNPDMEK 632
FD+S S PF+ L E + + LPFP+++P D+ +EC++F P P
Sbjct: 672 FDYSL-----SAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACP---- 722
Query: 633 DCPTIIHFVLANINFRKYKAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKR 692
+ P ++HF L N +F+ + APGV R + E + D+ P++ N Y + F+R
Sbjct: 723 EAPILLHFPLVNASFKDHSAPGVQR-SPAELQGGQVDL-TGATCPYTLSNMTYKEEDFER 780
Query: 693 LHDLMHFNTLNNIDVIKEAMVESIEYR 719
L L +N + I +A+ ++++R
Sbjct: 781 LLRLSDYNVQTSQGAILQALRTALKHR 807
Score = 58.9 bits (141), Expect = 2e-08
Identities = 33/97 (34%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 6 PYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNN 65
PYQ E + TV VL A + + D+L DPYV L +ST P + +T+ +
Sbjct: 13 PYQG---EASTCWQLTVRVLEARNLR---WADLLSEADPYVILQLSTAPGMKFKTKTLTD 66
Query: 66 DINPVWNETFEFILDPNQENVLEITLMDANYVMDETL 102
+PVWNE F F++ +NVLE+++ D + V ++ +
Sbjct: 67 TSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDI 103
>gi|167860120 phospholipase A2, group IVB [Homo sapiens]
Length = 781
Score = 241 bits (615), Expect = 2e-63
Identities = 187/656 (28%), Positives = 313/656 (47%), Gaps = 75/656 (11%)
Query: 74 TFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLE 133
TF F E L I L DA +E L +S++ G+ + F +Q M +E
Sbjct: 189 TFRFHCPACWEQELSIRLQDAP---EEQLKAP---LSALPSGQVVRLVFPTSQEPLMRVE 242
Query: 134 MSLEVCSCP-DLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAI 192
+ E +R C +E+ F +RK+ + ++++ L +G ++PVVAI
Sbjct: 243 LKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQAL---QLDGDLQEDEIPVVAI 299
Query: 193 LGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEIN 252
+ +GGG RAM G + L E G+LDC +Y+ G SGSTW ++ LY P++ +K
Sbjct: 300 MATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPT 359
Query: 253 EELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNT-T 311
E L V+ N L +L P +++RY + L ++ G P FT+++ LI E L+H+ +
Sbjct: 360 ELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWA-LINEALLHDEPHDHK 418
Query: 312 LSSLKEKVNTAQCPLPLFTCLHVK-PDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGS 370
LS +E ++ Q PLP++ L+ K ++ F +W EFSPYE+G KYG F+ +LFGS
Sbjct: 419 LSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGS 478
Query: 371 KFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIV 430
+FFMG ++K+ E+ + FL G+W + ++ L + S+ + +
Sbjct: 479 EFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQ----------FWDRWVR 528
Query: 431 SNDSSDSDD----ESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRA 486
+ + D + + EP T A ++ +D T A
Sbjct: 529 NQANLDKEQVPLLKIEEPPSTAGRIA--EFFTD-------------------LLTWRPLA 567
Query: 487 GKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIH 546
HNF+ GL+ + Y P F+T + D L P++ L +
Sbjct: 568 QATHNFLRGLHFHKDYFQHP--HFSTWKATTLDGL------PNQ-------LTPSEPHLC 612
Query: 547 VVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPK 606
++D G N +L+P R VDLI+S D++ + F++L L ++ + +PFP
Sbjct: 613 LLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGA-----FQQLQLLGRFCQEQGIPFPP 667
Query: 607 IDPYVFDREGLKECYVFK-PKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETEEEKEI 665
I P ++ +EC+ F P P P ++HF L + +FR+Y APGV R T EE
Sbjct: 668 ISPSPEEQLQPRECHTFSDPTCP----GAPAVLHFPLVSDSFREYSAPGV-RRTPEEAAA 722
Query: 666 ADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ 721
+ ++ +SP+ Y + +L L H+N NN + + EA+ ++++ RRQ
Sbjct: 723 GEVNL-SSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQ 777
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/124 (29%), Positives = 63/124 (50%), Gaps = 4/124 (3%)
Query: 21 TVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILD 80
TV VL+A ++ D++ D YV L++ T R +TR N +PVWN++F F +
Sbjct: 13 TVRVLQAHRLPSK---DLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIH 69
Query: 81 PNQENVLEITLMDANYVM-DETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVC 139
+NV+E+ + D + V D+ + + F +++ GE + F + E LE+ +
Sbjct: 70 RQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQ 129
Query: 140 SCPD 143
S D
Sbjct: 130 SLAD 133
>gi|4826914 JMJD7-PLA2G4B protein [Homo sapiens]
Length = 1012
Score = 241 bits (615), Expect = 2e-63
Identities = 187/656 (28%), Positives = 313/656 (47%), Gaps = 75/656 (11%)
Query: 74 TFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLE 133
TF F E L I L DA +E L +S++ G+ + F +Q M +E
Sbjct: 420 TFRFHCPACWEQELSIRLQDAP---EEQLKAP---LSALPSGQVVRLVFPTSQEPLMRVE 473
Query: 134 MSLEVCSCP-DLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAI 192
+ E +R C +E+ F +RK+ + ++++ L +G ++PVVAI
Sbjct: 474 LKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQAL---QLDGDLQEDEIPVVAI 530
Query: 193 LGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEIN 252
+ +GGG RAM G + L E G+LDC +Y+ G SGSTW ++ LY P++ +K
Sbjct: 531 MATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPT 590
Query: 253 EELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNT-T 311
E L V+ N L +L P +++RY + L ++ G P FT+++ LI E L+H+ +
Sbjct: 591 ELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWA-LINEALLHDEPHDHK 649
Query: 312 LSSLKEKVNTAQCPLPLFTCLHVK-PDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGS 370
LS +E ++ Q PLP++ L+ K ++ F +W EFSPYE+G KYG F+ +LFGS
Sbjct: 650 LSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGS 709
Query: 371 KFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIV 430
+FFMG ++K+ E+ + FL G+W + ++ L + S+ + +
Sbjct: 710 EFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQ----------FWDRWVR 759
Query: 431 SNDSSDSDD----ESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRA 486
+ + D + + EP T A ++ +D T A
Sbjct: 760 NQANLDKEQVPLLKIEEPPSTAGRIA--EFFTD-------------------LLTWRPLA 798
Query: 487 GKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIH 546
HNF+ GL+ + Y P F+T + D L P++ L +
Sbjct: 799 QATHNFLRGLHFHKDYFQHP--HFSTWKATTLDGL------PNQ-------LTPSEPHLC 843
Query: 547 VVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPK 606
++D G N +L+P R VDLI+S D++ + F++L L ++ + +PFP
Sbjct: 844 LLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGA-----FQQLQLLGRFCQEQGIPFPP 898
Query: 607 IDPYVFDREGLKECYVFK-PKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETEEEKEI 665
I P ++ +EC+ F P P P ++HF L + +FR+Y APGV R T EE
Sbjct: 899 ISPSPEEQLQPRECHTFSDPTCP----GAPAVLHFPLVSDSFREYSAPGV-RRTPEEAAA 953
Query: 666 ADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ 721
+ ++ +SP+ Y + +L L H+N NN + + EA+ ++++ RRQ
Sbjct: 954 GEVNL-SSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQ 1008
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/124 (29%), Positives = 63/124 (50%), Gaps = 4/124 (3%)
Query: 21 TVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILD 80
TV VL+A ++ D++ D YV L++ T R +TR N +PVWN++F F +
Sbjct: 244 TVRVLQAHRLPSK---DLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIH 300
Query: 81 PNQENVLEITLMDANYVM-DETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVC 139
+NV+E+ + D + V D+ + + F +++ GE + F + E LE+ +
Sbjct: 301 RQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQ 360
Query: 140 SCPD 143
S D
Sbjct: 361 SLAD 364
>gi|226693363 phospholipase A2, group IVC isoform 3 [Homo sapiens]
Length = 527
Score = 167 bits (422), Expect = 4e-41
Identities = 140/516 (27%), Positives = 237/516 (45%), Gaps = 79/516 (15%)
Query: 153 QEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKAL 212
+EK ++R+ H+ +++KKL A + PVVA+LGSGGG RA + GV+ +
Sbjct: 15 EEKAAVERRRLHVLKALKKLR--------IEADEAPVVAVLGSGGGLRAHIACLGVLSEM 66
Query: 213 YESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKV 272
E G+LD TY+AG+SGSTW +S+LY++ + E L ++ H T Q+
Sbjct: 67 KEQGLLDAVTYLAGVSGSTWAISSLYTN--------DGDMEALEADLKHR----FTRQEW 114
Query: 273 KRYVESLWK--KKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFT 330
+SL K + + + + TD + ++ + LS++K+ V P P+F
Sbjct: 115 D-LAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFA 173
Query: 331 CL--HVKPDVSELMFAD-WVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLH 387
+ ++P E + W EF+P+ G + G F++ FGSKF G +V+ + E L
Sbjct: 174 AIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLT 233
Query: 388 FLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHI----VSNDSSDSD----- 438
FL G+WGSA + ++ + ++L N+T K + V+N S
Sbjct: 234 FLRGLWGSA----------LGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFAR 283
Query: 439 ----DESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFML 494
ES + + ED G + + +W+ M+ T + + H
Sbjct: 284 LLRLQESSQGEHPPPEDEG----GEPEHTWLTEML------ENWTRTSLEKQEQPHE--- 330
Query: 495 GLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFER--IYEPLDVKSKKIHVVDSGL 552
+ LS L DF + + + ++ I + + K +H+VD+GL
Sbjct: 331 --DPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGL 388
Query: 553 TFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVF 612
N P+PL+L P R V LI+SFDFSA PF+ + + + +K+PFP+++
Sbjct: 389 AINTPFPLVLPPTREVHLILSFDFSA-----GDPFETIRATTDYCRRHKIPFPQVEEAEL 443
Query: 613 D--REGLKECYVFKPKNPDMEKDCPTIIHFVLANIN 646
D + CY+ K + P ++HF L NI+
Sbjct: 444 DLWSKAPASCYILKGETG------PVVMHFPLFNID 473
>gi|226693357 phospholipase A2, group IVC isoform 2 precursor [Homo
sapiens]
Length = 551
Score = 167 bits (422), Expect = 4e-41
Identities = 140/516 (27%), Positives = 237/516 (45%), Gaps = 79/516 (15%)
Query: 153 QEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKAL 212
+EK ++R+ H+ +++KKL A + PVVA+LGSGGG RA + GV+ +
Sbjct: 25 EEKAAVERRRLHVLKALKKLR--------IEADEAPVVAVLGSGGGLRAHIACLGVLSEM 76
Query: 213 YESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKV 272
E G+LD TY+AG+SGSTW +S+LY++ + E L ++ H T Q+
Sbjct: 77 KEQGLLDAVTYLAGVSGSTWAISSLYTN--------DGDMEALEADLKHR----FTRQEW 124
Query: 273 KRYVESLWK--KKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFT 330
+SL K + + + + TD + ++ + LS++K+ V P P+F
Sbjct: 125 D-LAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFA 183
Query: 331 CL--HVKPDVSELMFAD-WVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLH 387
+ ++P E + W EF+P+ G + G F++ FGSKF G +V+ + E L
Sbjct: 184 AIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLT 243
Query: 388 FLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHI----VSNDSSDSD----- 438
FL G+WGSA + ++ + ++L N+T K + V+N S
Sbjct: 244 FLRGLWGSA----------LGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFAR 293
Query: 439 ----DESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFML 494
ES + + ED G + + +W+ M+ T + + H
Sbjct: 294 LLRLQESSQGEHPPPEDEG----GEPEHTWLTEML------ENWTRTSLEKQEQPHE--- 340
Query: 495 GLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFER--IYEPLDVKSKKIHVVDSGL 552
+ LS L DF + + + ++ I + + K +H+VD+GL
Sbjct: 341 --DPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGL 398
Query: 553 TFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVF 612
N P+PL+L P R V LI+SFDFSA PF+ + + + +K+PFP+++
Sbjct: 399 AINTPFPLVLPPTREVHLILSFDFSA-----GDPFETIRATTDYCRRHKIPFPQVEEAEL 453
Query: 613 D--REGLKECYVFKPKNPDMEKDCPTIIHFVLANIN 646
D + CY+ K + P ++HF L NI+
Sbjct: 454 DLWSKAPASCYILKGETG------PVVMHFPLFNID 483
>gi|226693354 phospholipase A2, group IVC isoform 1 precursor [Homo
sapiens]
Length = 541
Score = 167 bits (422), Expect = 4e-41
Identities = 140/516 (27%), Positives = 237/516 (45%), Gaps = 79/516 (15%)
Query: 153 QEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKAL 212
+EK ++R+ H+ +++KKL A + PVVA+LGSGGG RA + GV+ +
Sbjct: 15 EEKAAVERRRLHVLKALKKLR--------IEADEAPVVAVLGSGGGLRAHIACLGVLSEM 66
Query: 213 YESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKV 272
E G+LD TY+AG+SGSTW +S+LY++ + E L ++ H T Q+
Sbjct: 67 KEQGLLDAVTYLAGVSGSTWAISSLYTN--------DGDMEALEADLKHR----FTRQEW 114
Query: 273 KRYVESLWK--KKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFT 330
+SL K + + + + TD + ++ + LS++K+ V P P+F
Sbjct: 115 D-LAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFA 173
Query: 331 CL--HVKPDVSELMFAD-WVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLH 387
+ ++P E + W EF+P+ G + G F++ FGSKF G +V+ + E L
Sbjct: 174 AIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLT 233
Query: 388 FLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHI----VSNDSSDSD----- 438
FL G+WGSA + ++ + ++L N+T K + V+N S
Sbjct: 234 FLRGLWGSA----------LGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFAR 283
Query: 439 ----DESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFML 494
ES + + ED G + + +W+ M+ T + + H
Sbjct: 284 LLRLQESSQGEHPPPEDEG----GEPEHTWLTEML------ENWTRTSLEKQEQPHE--- 330
Query: 495 GLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFER--IYEPLDVKSKKIHVVDSGL 552
+ LS L DF + + + ++ I + + K +H+VD+GL
Sbjct: 331 --DPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGL 388
Query: 553 TFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVF 612
N P+PL+L P R V LI+SFDFSA PF+ + + + +K+PFP+++
Sbjct: 389 AINTPFPLVLPPTREVHLILSFDFSA-----GDPFETIRATTDYCRRHKIPFPQVEEAEL 443
Query: 613 D--REGLKECYVFKPKNPDMEKDCPTIIHFVLANIN 646
D + CY+ K + P ++HF L NI+
Sbjct: 444 DLWSKAPASCYILKGETG------PVVMHFPLFNID 473
>gi|19718759 myoferlin isoform b [Homo sapiens]
Length = 2048
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 11/105 (10%)
Query: 22 VVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFIL-- 79
V+V A+ + K FG PDP V + D +K+T+ +N++NPVWNE EF L
Sbjct: 4 VIVESASNIPKTKFGK----PDPIVSVIFK---DEKKKTKKVDNELNPVWNEILEFDLRG 56
Query: 80 -DPNQENVLEITLMDANYV-MDETLGTATFTVSSMKVGEKKEVPF 122
+ + L I + D + ++ +GTAT + + + + +P+
Sbjct: 57 IPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPY 101
>gi|7305053 myoferlin isoform a [Homo sapiens]
Length = 2061
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 11/105 (10%)
Query: 22 VVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFIL-- 79
V+V A+ + K FG PDP V + D +K+T+ +N++NPVWNE EF L
Sbjct: 4 VIVESASNIPKTKFGK----PDPIVSVIFK---DEKKKTKKVDNELNPVWNEILEFDLRG 56
Query: 80 -DPNQENVLEITLMDANYV-MDETLGTATFTVSSMKVGEKKEVPF 122
+ + L I + D + ++ +GTAT + + + + +P+
Sbjct: 57 IPLDFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPY 101
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/95 (28%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 43 DPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETL 102
DPY ++ I R+R ++NP WNE FEF++ LE+ L D + D+ L
Sbjct: 332 DPYAKVSIGL---QHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFL 388
Query: 103 GTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLE 137
G+ + + + F+ N T L + LE
Sbjct: 389 GSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLE 423
Score = 30.4 bits (67), Expect = 6.3
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 3/68 (4%)
Query: 26 RATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQEN 85
RA K+++ A + P YV+L + + K H N D PVW++ F F +
Sbjct: 469 RAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPH-NKD--PVWSQVFSFFVHNVATE 525
Query: 86 VLEITLMD 93
L + ++D
Sbjct: 526 RLHLKVLD 533
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 10/98 (10%)
Query: 43 DPYVELFI--STTPDSRKRTRHFNNDINPVWNETFEF--ILDPN-QENVLEITLMDAN-Y 96
DPYV+L + + ++ RT+ N NP+WNET + I D + Q L I++ D + +
Sbjct: 429 DPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF 488
Query: 97 VMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEM 134
+E +G F++ +K ++K FN E V+ M
Sbjct: 489 GHNEFIGETRFSLKKLKPNQRKN----FNICLERVIPM 522
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 10/98 (10%)
Query: 43 DPYVELFI--STTPDSRKRTRHFNNDINPVWNETFEF--ILDPN-QENVLEITLMDAN-Y 96
DPYV+L + + ++ RT+ N NP+WNET + I D + Q L I++ D + +
Sbjct: 425 DPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF 484
Query: 97 VMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEM 134
+E +G F++ +K ++K FN E V+ M
Sbjct: 485 GHNEFIGETRFSLKKLKPNQRKN----FNICLERVIPM 518
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 8/87 (9%)
Query: 33 GAFGDMLDTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLE 88
GA GD++D PYV + I P + R +T H N D P+++E+FEF ++ + ++
Sbjct: 773 GAKGDVVD---PYVYVEIHGIPADCAEQRTKTVHQNGDA-PIFDESFEFQINLPELAMVR 828
Query: 89 ITLMDANYVMDETLGTATFTVSSMKVG 115
++D +Y+ DE +G T ++ G
Sbjct: 829 FVVLDDDYIGDEFIGQYTIPFECLQTG 855
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 8/87 (9%)
Query: 33 GAFGDMLDTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLE 88
GA GD++D PYV + I P + R +T H N D P+++E+FEF ++ + ++
Sbjct: 647 GAKGDVVD---PYVYVEIHGIPADCAEQRTKTVHQNGDA-PIFDESFEFQINLPELAMVR 702
Query: 89 ITLMDANYVMDETLGTATFTVSSMKVG 115
++D +Y+ DE +G T ++ G
Sbjct: 703 FVVLDDDYIGDEFIGQYTIPFECLQTG 729
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/80 (31%), Positives = 44/80 (55%), Gaps = 5/80 (6%)
Query: 40 DTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDAN 95
D DPYV + I P + R +T N+D NP+++ETFEF ++ + ++ ++D +
Sbjct: 744 DVIDPYVCIEIHGIPADCSEQRTKTVQQNSD-NPIFDETFEFQVNLPELAMIRFVVLDDD 802
Query: 96 YVMDETLGTATFTVSSMKVG 115
Y+ DE +G T ++ G
Sbjct: 803 YIGDEFIGQYTIPFECLQPG 822
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/80 (31%), Positives = 44/80 (55%), Gaps = 5/80 (6%)
Query: 40 DTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDAN 95
D DPYV + I P + R +T N+D NP+++ETFEF ++ + ++ ++D +
Sbjct: 646 DVIDPYVCIEIHGIPADCSEQRTKTVQQNSD-NPIFDETFEFQVNLPELAMIRFVVLDDD 704
Query: 96 YVMDETLGTATFTVSSMKVG 115
Y+ DE +G T ++ G
Sbjct: 705 YIGDEFIGQYTIPFECLQPG 724
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/74 (31%), Positives = 44/74 (59%), Gaps = 4/74 (5%)
Query: 43 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFILDP-NQENVLEITLMD-ANYVM 98
DPYV+L + P +S+++T+ + +NP WNE+F F L P +++ L + + D
Sbjct: 193 DPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252
Query: 99 DETLGTATFTVSSM 112
++ +G+ +F VS +
Sbjct: 253 NDFMGSLSFGVSEL 266
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/74 (35%), Positives = 41/74 (55%), Gaps = 4/74 (5%)
Query: 43 DPYVELFISTTPDS--RKRTRHFNNDINPVWNETFEFILDPNQ-ENVLEITLMDANYV-M 98
DPYV+L + P + +++TR +NPVWNETF F L P E L + + D +
Sbjct: 193 DPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSR 252
Query: 99 DETLGTATFTVSSM 112
++ +G +F VS +
Sbjct: 253 NDFMGAMSFGVSEL 266
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 37 DMLDTPDPYVELFISTTPDSRK----RTRHFNNDINPVWNETFEFILDPNQENVLEITLM 92
D+ DPYV+L + ++R+ +T+ +NP WNE F F ++P+ +L
Sbjct: 36 DIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFD 95
Query: 93 DANYVMDETLGTATFTVSSMKVGE-KKEVPFIF 124
+ D+ LG +S + + E P+ F
Sbjct: 96 ENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 128
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 37 DMLDTPDPYVELFISTTPDSRK----RTRHFNNDINPVWNETFEFILDPNQENVLEITLM 92
D+ DPYV+L + ++R+ +T+ +NP WNE F F ++P+ +L
Sbjct: 28 DIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFD 87
Query: 93 DANYVMDETLGTATFTVSSMKVGE-KKEVPFIF 124
+ D+ LG +S + + E P+ F
Sbjct: 88 ENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 37 DMLDTPDPYVELFISTTPDSRK----RTRHFNNDINPVWNETFEFILDPNQENVLEITLM 92
D+ DPYV+L + ++R+ +T+ +NP WNE F F ++P+ +L
Sbjct: 28 DIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFD 87
Query: 93 DANYVMDETLGTATFTVSSMKVGE-KKEVPFIF 124
+ D+ LG +S + + E P+ F
Sbjct: 88 ENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 37 DMLDTPDPYVELFISTTPDSRK----RTRHFNNDINPVWNETFEFILDPNQENVLEITLM 92
D+ DPYV+L + ++R+ +T+ +NP WNE F F ++P+ +L
Sbjct: 36 DIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFD 95
Query: 93 DANYVMDETLGTATFTVSSMKVGE-KKEVPFIF 124
+ D+ LG +S + + E P+ F
Sbjct: 96 ENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 128
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/75 (29%), Positives = 45/75 (60%), Gaps = 4/75 (5%)
Query: 43 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYV-M 98
DPYV+L + P +S+++T+ +NP WNETF F L + +++ L + + D +
Sbjct: 193 DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252
Query: 99 DETLGTATFTVSSMK 113
++ +G+ +F +S ++
Sbjct: 253 NDFMGSLSFGISELQ 267
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/75 (29%), Positives = 45/75 (60%), Gaps = 4/75 (5%)
Query: 43 DPYVELFISTTP--DSRKRTRHFNNDINPVWNETFEFIL-DPNQENVLEITLMDANYV-M 98
DPYV+L + P +S+++T+ +NP WNETF F L + +++ L + + D +
Sbjct: 193 DPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252
Query: 99 DETLGTATFTVSSMK 113
++ +G+ +F +S ++
Sbjct: 253 NDFMGSLSFGISELQ 267
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/65 (32%), Positives = 38/65 (58%), Gaps = 4/65 (6%)
Query: 15 QYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKR--TRHFNNDINPVWN 72
QY ++ ++V++ K D T DPYV++++ PD +K+ TR +NP+++
Sbjct: 240 QYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYL--LPDRKKKFQTRVHRKTLNPLFD 297
Query: 73 ETFEF 77
ETF+F
Sbjct: 298 ETFQF 302
Score = 32.0 bits (71), Expect = 2.2
Identities = 22/65 (33%), Positives = 36/65 (55%), Gaps = 6/65 (9%)
Query: 37 DMLDTPDPYVELFISTTPD--SRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDA 94
D+ + DPYV++ + +++T N +NPV+NE F + P ENV +++L A
Sbjct: 394 DITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPP--ENVDQVSLSIA 451
Query: 95 NYVMD 99
VMD
Sbjct: 452 --VMD 454
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 38.9 bits (89), Expect = 0.018
Identities = 27/70 (38%), Positives = 42/70 (60%), Gaps = 8/70 (11%)
Query: 17 SHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKR--TRHFNNDINPVWNET 74
+++ TV VL+A ++ DM T DPYV++F+ PD +K+ T+ +NP +NET
Sbjct: 153 ANQLTVGVLQAAELPAL---DMGGTSDPYVKVFL--LPDKKKKYETKVHRKTLNPAFNET 207
Query: 75 FEFILDPNQE 84
F F + P QE
Sbjct: 208 FTFKV-PYQE 216
Score = 32.7 bits (73), Expect = 1.3
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 5/80 (6%)
Query: 19 KFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPD--SRKRTRHFNNDINPVWNETFE 76
K TV +L A + K G + DPYV++ + +K+T +NP +NE+F
Sbjct: 286 KLTVCILEAKNLKKMDVGGL---SDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFS 342
Query: 77 FILDPNQENVLEITLMDANY 96
F + Q +++ + +Y
Sbjct: 343 FEIPFEQIQKVQVVVTVLDY 362
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 38.9 bits (89), Expect = 0.018
Identities = 27/70 (38%), Positives = 42/70 (60%), Gaps = 8/70 (11%)
Query: 17 SHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKR--TRHFNNDINPVWNET 74
+++ TV VL+A ++ DM T DPYV++F+ PD +K+ T+ +NP +NET
Sbjct: 153 ANQLTVGVLQAAELPAL---DMGGTSDPYVKVFL--LPDKKKKYETKVHRKTLNPAFNET 207
Query: 75 FEFILDPNQE 84
F F + P QE
Sbjct: 208 FTFKV-PYQE 216
Score = 32.7 bits (73), Expect = 1.3
Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 5/80 (6%)
Query: 19 KFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPD--SRKRTRHFNNDINPVWNETFE 76
K TV +L A + K G + DPYV++ + +K+T +NP +NE+F
Sbjct: 286 KLTVCILEAKNLKKMDVGGL---SDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFS 342
Query: 77 FILDPNQENVLEITLMDANY 96
F + Q +++ + +Y
Sbjct: 343 FEIPFEQIQKVQVVVTVLDY 362
>gi|24308219 synaptotagmin IV [Homo sapiens]
Length = 425
Score = 38.9 bits (89), Expect = 0.018
Identities = 27/111 (24%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 12 VEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVW 71
+E+ + K VV ++ + A + T DPY+++ I + +TR ++P +
Sbjct: 161 LEYNFERKAFVVNIKEARGLP-AMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPAF 219
Query: 72 NETFEFILDPN---QENVLEITLMDAN-YVMDETLGTATFTVSSMKVGEKK 118
+ETF F P QE L T++ + + D+ +G +S +++ E K
Sbjct: 220 DETFTFYGIPYTQIQELALHFTILSFDRFSRDDIIGEVLIPLSGIELSEGK 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,154,810
Number of Sequences: 37866
Number of extensions: 1344179
Number of successful extensions: 4219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 4014
Number of HSP's gapped (non-prelim): 221
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.