BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo sapiens] (624 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 1221 0.0 gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 995 0.0 gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 345 7e-95 gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 178 1e-44 gi|55741709 RNA binding motif protein 25 [Homo sapiens] 164 3e-40 gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 162 1e-39 gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 158 2e-38 gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 151 2e-36 gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 149 8e-36 gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 145 8e-35 gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 140 3e-33 gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 139 1e-32 gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 138 1e-32 gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 132 1e-30 gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 129 8e-30 gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 129 8e-30 gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 127 4e-29 gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 125 2e-28 gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 119 6e-27 gi|20070262 TNF receptor-associated factor 3 interacting protein... 116 7e-26 gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 116 7e-26 gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 115 2e-25 gi|213385278 TNF receptor-associated factor 3 interacting protei... 114 4e-25 gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 113 5e-25 gi|52426743 cisplatin resistance-associated overexpressed protei... 112 1e-24 gi|19923485 cisplatin resistance-associated overexpressed protei... 112 1e-24 gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 111 2e-24 gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 110 3e-24 gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 110 3e-24 gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 107 3e-23 >gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo sapiens] Length = 624 Score = 1221 bits (3160), Expect = 0.0 Identities = 624/624 (100%), Positives = 624/624 (100%) Query: 1 MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF 60 MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF Sbjct: 1 MNSGGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAF 60 Query: 61 SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL 120 SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL Sbjct: 61 SSKVCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSL 120 Query: 121 MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI 180 MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI Sbjct: 121 MPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEI 180 Query: 181 RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA 240 RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA Sbjct: 181 RRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALA 240 Query: 241 FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS 300 FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS Sbjct: 241 FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKS 300 Query: 301 NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 360 NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK Sbjct: 301 NERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 360 Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420 Query: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480 Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD Sbjct: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540 Query: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE Sbjct: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600 Query: 601 ENKIQHNGNCQLNEENLSTKTEAV 624 ENKIQHNGNCQLNEENLSTKTEAV Sbjct: 601 ENKIQHNGNCQLNEENLSTKTEAV 624 >gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo sapiens] Length = 508 Score = 995 bits (2573), Expect = 0.0 Identities = 508/508 (100%), Positives = 508/508 (100%) Query: 117 MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK 176 MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK Sbjct: 1 MTSLMPGAGLLPIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSK 60 Query: 177 IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP 236 IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP Sbjct: 61 IDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVP 120 Query: 237 RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE 296 RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE Sbjct: 121 RALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPE 180 Query: 297 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK 356 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK Sbjct: 181 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK 240 Query: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 300 Query: 417 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK Sbjct: 301 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 360 Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE Sbjct: 361 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420 Query: 537 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 596 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA Sbjct: 421 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 480 Query: 597 PRTEENKIQHNGNCQLNEENLSTKTEAV 624 PRTEENKIQHNGNCQLNEENLSTKTEAV Sbjct: 481 PRTEENKIQHNGNCQLNEENLSTKTEAV 508 >gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] Length = 484 Score = 345 bits (885), Expect = 7e-95 Identities = 228/551 (41%), Positives = 307/551 (55%), Gaps = 104/551 (18%) Query: 4 GGGFGLGLGFGLTPTSVIQVTNLSSAVTSEQMRTLFSFLGEIEELRLYPPDNAPLAFSSK 63 GGG G G G G T VIQVTN+S + +SEQMRTLF FLG+I+ELRL+PPD++PL SS+ Sbjct: 21 GGGGGGGGGGG---TEVIQVTNVSPSASSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSR 77 Query: 64 VCYVKFRDPSSVGVAQHLTNTVFIDRALIVVPCAEGKIPEESKALSLLAPAPTMTSLMPG 123 VC+VKF DP S VAQHLTNTVF+DRALIVVP AEG IP+E+KALSLLAPA + L+PG Sbjct: 78 VCFVKFHDPDSAVVAQHLTNTVFVDRALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPG 137 Query: 124 AGLLPIPTPNPLTTLG-VSLSSLGAIPAAALDPNIATLGEIPQPPLMGNVDPSKIDEIRR 182 GLL PTPNPLT +G V L++LG A LDP +A LG L G Sbjct: 138 GGLL--PTPNPLTQIGAVPLAALG---APTLDPALAALG------LPG------------ 174 Query: 183 TVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRALAFN 242 NLNSQ+ ADQLL+ V Sbjct: 175 ----ANLNSQSLAADQLLKLMSTVDP---------------------------------- 196 Query: 243 GVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNE 302 K+NH +V P + ++KE+EE MKRVREAQS ISAAIEP+ K + Sbjct: 197 ---------KLNHVAAGLVS-PSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDK-KEEK 245 Query: 303 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSR 362 R+ RSRS +R R + S SR +RS+S+ R RSH++SRS RRRSKSP ++RS SR Sbjct: 246 RRHSRSRSRSR---RRRTPSSSRHRRSRSRSRRRSHSKSRS----RRRSKSPRRRRSHSR 298 Query: 363 ER-RKSRSRSHSRDKRKDTREKIKEKERVK-----EKDREKEREREKEREKEKERGKNKD 416 ER R+SRS S +RDK+K+ +EK + K K + R RER + R + R K Sbjct: 299 ERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP 358 Query: 417 RDKEREKDR-------EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469 R +R+ R +K+K+KD+++ER ++ + +K+K +DKEK+RE+ Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRER-------- 410 Query: 470 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 529 K + DK + R Y+ + S +E++ + + SP+T + K + S+ Sbjct: 411 KSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKV 470 Query: 530 KKDKKREKERD 540 D E++ D Sbjct: 471 NGDDHHEEDMD 481 Score = 148 bits (374), Expect = 1e-35 Identities = 104/308 (33%), Positives = 158/308 (51%), Gaps = 54/308 (17%) Query: 322 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR 381 S S + + SK + R R Q + P KK K RR SRSRS SR +R + Sbjct: 207 SPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEK---RRHSRSRSRSRRRRTPSS 263 Query: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER-EREKE 440 + + R + + R +K R + R K + + RER R + Sbjct: 264 SR-----------------HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRS 306 Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500 K RDK+KE DKEK K+S+TPP+SY+ +RRSRS+SRERRRR Sbjct: 307 TSKTRDKKKE---DKEK-----------------KRSKTPPKSYSTARRSRSASRERRRR 346 Query: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSND 560 RSRS +RSP+ ++ KRK SRSPSPR R+KK+KK++K+++ R ERERSTS +K S D Sbjct: 347 RSRSGTRSPKKPRSPKRKLSRSPSPR-RHKKEKKKDKDKER--SRDERERSTSKKKKSKD 403 Query: 561 RD-GKEKLEKNSTSLK---------EKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNC 610 ++ +E+ ++ +K E+ ++ E + K+ + +P+T+E ++ Sbjct: 404 KEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGD 463 Query: 611 QLNEENLS 618 L E ++ Sbjct: 464 SLRESKVN 471 >gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo sapiens] Length = 600 Score = 178 bits (452), Expect = 1e-44 Identities = 104/341 (30%), Positives = 187/341 (54%), Gaps = 48/341 (14%) Query: 299 KSNERKGGRSRSHTRSKSRSSSKS-HSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 357 + ER+ R R R K R + H R+R + K R R +R R RQ+++ R++ ++ Sbjct: 69 RQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERE 128 Query: 358 RSKSRERRKSRSRS----HSRDKRKDTR---------------EKIKEKERVKEKDREKE 398 R RE + R R R++++D E+ ++KER +EK+R++ Sbjct: 129 RETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQER 188 Query: 399 REREKEREKE-------KERGKNKDRDKE--------REKDREKDKEKDREREREKEHEK 443 RERE++REKE ERG+ ++R++E R+ DRE+D+++ EREREK+ E+ Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER 248 Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503 +R E+E E+DKE+ERE+DR ++ D +R+K+++ +T + + R R + R+R R+R R Sbjct: 249 ERASERETERDKERERERDRDRDRD-RRQKERERQTDRKRQRRTERDRETERKRERQRER 307 Query: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RERERSTSMRKSSNDRD 562 R + +R+ R +++++RE ERD ER R+R+R T M + N + Sbjct: 308 ERERERNRKRERERERER--------ERERQRETERDREKERERKRKRQTEMDRERNRQT 359 Query: 563 GKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 G+E + + +E+E +E D ++E ++++ R + + Sbjct: 360 GREGRRQ---AERERERERERDRQSAREREERERDRDRDRQ 397 Score = 175 bits (443), Expect = 1e-43 Identities = 94/312 (30%), Positives = 181/312 (58%), Gaps = 23/312 (7%) Query: 314 SKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDRRR---SKSPHKKRSKSRERRKSRS 369 S+ R S+ RR+ H+ +R R+RQK+R R + ++ + RERR+ + Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86 Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD----- 424 R RD+ ++ R++ +EKER ++ DRE++R+REKER ++KER + +R+ ER +D Sbjct: 87 RHRKRDRHRE-RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145 Query: 425 -REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRS 483 RE+++++D E+ERE++ +++R ++ E+ + KE+EREK+R + + +R+++K+++T R Sbjct: 146 QRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRH 205 Query: 484 YNASR-----RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE 538 R R + ER+R+ R R +T + ++++ R + ++DK+RE+E Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERE 265 Query: 539 RDHISER----RERERSTS---MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 591 RD +R +ERER T R++ DR+ + K E+ +E+E N++ + +E Sbjct: 266 RDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERER 325 Query: 592 DDKDAPRTEENK 603 + + TE ++ Sbjct: 326 ERERQRETERDR 337 Score = 172 bits (437), Expect = 6e-43 Identities = 105/370 (28%), Positives = 187/370 (50%), Gaps = 34/370 (9%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331 KE E R R+ Q E E + ER+ R R + R + R R+R Sbjct: 103 KERERQTDRERDRQR------EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156 Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR--EKIKEKER 389 K R R +R R RQ +R R K ++R K+R+ R+ R R ++ + + R E+ +E+ER Sbjct: 157 KERERQTDRERQRQTERNRQKE--REREKNRQERRERERQREKENKTEDRHSERGRERER 214 Query: 390 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDR--EKDKEKDREREREKEHEKDRD- 446 +E + E ER+R+ +RE++++R ++R+K+ E++R E++ E+D+ERERE++ ++DRD Sbjct: 215 ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDR 274 Query: 447 --KEKEK----------EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS 494 KE+E+ E+D+E ER+++R +E + +R++++K R R + Sbjct: 275 RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334 Query: 495 RERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSM 554 R+R + R R R + R++ R ++ +++++RE++R ER ERER Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394 Query: 555 -------RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607 R++ DRDG+ + EK K++E + + +E K R E + Sbjct: 395 DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE-KQKGRERDRERQTDRQ 453 Query: 608 GNCQLNEENL 617 Q L Sbjct: 454 AGRQRKRSTL 463 Score = 169 bits (427), Expect = 9e-42 Identities = 91/316 (28%), Positives = 172/316 (54%), Gaps = 17/316 (5%) Query: 289 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348 + A + G ER + R R K ++ ++ +R+R + K R R +R R RQ+DR Sbjct: 42 LGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDR 101 Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-------REKIKEKERVKEKDREKERER 401 + + R + R+R K R+R R++ + R+ ++ER +++D EKERER Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161 Query: 402 EKEREKEKERGKNKDRDKEREKDREKDKEKDRERERE-----KEHEKDRDKEKEKEQDKE 456 + +RE++++ +N+ +++EREK+R++ +E++R+RE+E + E+ R++E+E+E + E Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETE 221 Query: 457 KEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516 ER++ +E D +RK +++ AS R +ER R R R R R K + Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD-RRQKERE 280 Query: 517 RKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKE 576 R++ R R+ ++ +R++ER E RERER+ RK +R+ + + E+ + ++ Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERE-RERERN---RKRERERERERERERQRETERD 336 Query: 577 KEHNKEPDSSVSKEVD 592 +E +E E+D Sbjct: 337 REKERERKRKRQTEMD 352 Score = 166 bits (419), Expect = 8e-41 Identities = 92/306 (30%), Positives = 173/306 (56%), Gaps = 11/306 (3%) Query: 271 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 330 A KE E R R+ Q+ + E E K+ + + R R R K + HS R R + Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQER--RERERQREKENKTEDRHSERGRER 212 Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV 390 + R R RQ DR R + +K + RE++ R R+ R+ +D +E+ +E++R Sbjct: 213 ERERETETETERKRQTDRERDRQ--RKTEREREKQAERERASERETERD-KERERERDRD 269 Query: 391 KEKDR---EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 447 +++DR E+ER+ +++R++ ER + +R +ER+++RE+++E++R+RERE+E E++R++ Sbjct: 270 RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERER 329 Query: 448 EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSR 507 ++E E+D+EKERE+ R ++ + R++++++ R R R R+R+ R R Sbjct: 330 QRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389 Query: 508 SPRTSKTIKRKSSRSPSPR-SRNKKDKKREKERDHISER-RERERSTSMRKSSNDRDGKE 565 R K + ++ R + + +K+RE+E+D SER RER R +K +RD + Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQK-GRERDRER 448 Query: 566 KLEKNS 571 + ++ + Sbjct: 449 QTDRQA 454 Score = 144 bits (363), Expect = 2e-34 Identities = 89/303 (29%), Positives = 159/303 (52%), Gaps = 32/303 (10%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 ++ + +R RE Q+ A E E+ + ER+ R R R + + + + RKR + Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS--RDKRKDTREKIK----- 385 R R R R RQ++R R + ++KR + RER + R R RD+ K+ K K Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM 351 Query: 386 EKERVKEKDREKEREREKEREKEKERGKN-----KDRDKEREKDREKDKEK--------- 431 ++ER ++ RE R+ E+ERE+E+ER + ++R+++R++DR+K++E+ Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ 411 Query: 432 ---DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT-----PPRS 483 +++REREK+ E +R +E+ +E++K+K RE+DR ++ D + + +K T PPR+ Sbjct: 412 RETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471 Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS 543 + +R R R +SS P+ + T R P+ SR + +R E + Sbjct: 472 ARSGVVQSDPNRPTRGIRWKSSPEDPKAAST--RFPWGRPAKASRGRVAGRRRWE-PRLG 528 Query: 544 ERR 546 E+R Sbjct: 529 EKR 531 Score = 71.6 bits (174), Expect = 2e-12 Identities = 57/219 (26%), Positives = 106/219 (48%), Gaps = 34/219 (15%) Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---------REKDRSKE 466 D + R +E + + + + DR++ ++KE+++ +E R+++R +E Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84 Query: 467 IDEKRKKDK-KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525 D RK+D+ + R R R R + RER R+R + +R + +R+ R Sbjct: 85 KDRHRKRDRHRERQRDRE---KERERQTDRERDRQREKERNRQKERERETEREGERG--- 138 Query: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585 R R + D +RE+ER +E +ERER T DR+ + + E+N +E+E N++ Sbjct: 139 RDR-QTDGQRERERQRDAE-KERERQT-------DRERQRQTERNRQKEREREKNRQ--- 186 Query: 586 SVSKEVDDKDAPRTEENKIQ--HNGNCQLNEENLSTKTE 622 E +++ R +ENK + H+ + E T+TE Sbjct: 187 ----ERRERERQREKENKTEDRHSERGRERERERETETE 221 >gi|55741709 RNA binding motif protein 25 [Homo sapiens] Length = 843 Score = 164 bits (414), Expect = 3e-40 Identities = 139/574 (24%), Positives = 251/574 (43%), Gaps = 87/574 (15%) Query: 128 PIPTPNPLTTLGVSLSSLGAIPAAALDPNIATLGEI-----PQPPLMGNVDPSKIDEIRR 182 P P P + V +S + P L P ++ +G+ P L + Sbjct: 30 PPPVPPGTPMIPVPMSIMAPAPTV-LVPTVSMVGKHLGARKDHPGLKAKENDENCGPTT- 87 Query: 183 TVYVGNLNSQTTTADQLL-EFFKQVGEV-KFVRMAGDETQPTRFAFVEFADQNSVPRALA 240 TV+VGN++ + + D L+ + + G V + R+ G + F F E+ + S RAL Sbjct: 88 TVFVGNISEKAS--DMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALR 145 Query: 241 F-NGVMFGDRPLKIN----------------HSNNAIVKPPEMTPQAAAKELEEVMKRVR 283 + + G++ L + ++N +P +T EE +R + Sbjct: 146 LLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQ 205 Query: 284 EAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR----------------- 326 + I I S + N S SH R K + + RR Sbjct: 206 MIKGAIEVLIREYSSELNA-PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDI 264 Query: 327 ---KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE-----RRKSRSRSHSRDKRK 378 + + K S S+ R ++ + KK + +E R + R R R++R+ Sbjct: 265 NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRE 324 Query: 379 DTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD-------------- 424 RE+ +E+ER KEK+RE+ERER+++R++ KER +++DR+++R++D Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 REK ++++RERERE+E E++R++E+E+E+++E+ERE++R +E D+KR +++ Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE------ 538 R+ R + R R + ++ ++++ R R K+ KR KE Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504 Query: 539 ---------RDHISERRERERSTSMRKSSNDRD-GKEKLEKNSTSLKEKEHNKEPDSSVS 588 R ++R R+R M DR KE+LE+ L + H PD Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH---PDPDAE 561 Query: 589 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622 + +++A R + +I+ + EE K E Sbjct: 562 LQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595 Score = 152 bits (383), Expect = 1e-36 Identities = 88/314 (28%), Positives = 166/314 (52%), Gaps = 10/314 (3%) Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352 +E E GK E++ R + R + RR+R + + R R + + R+++R R + Sbjct: 291 LEEEKGKK-EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349 Query: 353 SPHKKRSKSRERRKSRSRSHSRDK-RKDTREKIKEKERVKEKDREKEREREKEREKEKER 411 + R+K R+R + R R RD+ R R K + + R K +DRE+ERERE+ERE+E+ER Sbjct: 350 D--RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407 Query: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE---REKDRSKEID 468 + ++R++ERE++RE+++EKD++R+RE++ E ++ K + + +EKE +E+ ++ EI Sbjct: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467 Query: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528 E++K + + R RR + +R + R R S+ R R Sbjct: 468 ERKKTREYEKEAER--EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDR 525 Query: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSV 587 K+ + E++R E E R + + D D + +++E+ + ++ + +EP+S Sbjct: 526 EKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585 Query: 588 SKEVDDKDAPRTEE 601 +E + + EE Sbjct: 586 EEEEKQEKEEKREE 599 Score = 126 bits (317), Expect = 5e-29 Identities = 85/310 (27%), Positives = 144/310 (46%), Gaps = 39/310 (12%) Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335 EE K+ +E Q E E + ER+ R R R + R K R+R + + R Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERER-REREREREREREREKE-KERERERERDRD 350 Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395 R + R R +DR R + ++RS R + +SRSR SRD+ ++ RE+ +E+ER +E++R Sbjct: 351 RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE-RERERERERERERER 409 Query: 396 EKEREREKEREKEKERGKNKDRDKE----------------REKDR-------------- 425 E+ERERE+ERE+E+ER K+K RD+E REK+ Sbjct: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469 Query: 426 ------EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479 EK+ E++ ER RE E R KE ++ D +++ K +KR +D++ Sbjct: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM 529 Query: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKER 539 + R R+R + + +++++ R P+ + + + + E+E Sbjct: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589 Query: 540 DHISERRERE 549 E + E Sbjct: 590 KQEKEEKREE 599 Score = 108 bits (270), Expect = 1e-23 Identities = 79/309 (25%), Positives = 140/309 (45%), Gaps = 45/309 (14%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-RSQS 331 +E E +R RE + E + + ++ R R R + R +S R K RS+S Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384 Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE--------- 382 + +SR R R R+++R R + ++R + RER + R R +DK++D E Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444 Query: 383 ----KIKEKE----------RVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDRE 426 K++EKE ++E+ + +E E+E ERE+E+ R K R KE +D + Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504 Query: 427 KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 486 D++ + ++ RD+EKE E D E++R++++ +E++E R++ P Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREK-EELEEIRQRLLAEGHPDPDAEL 562 Query: 487 SRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546 R +E RRR + P S +K +K EK + + E Sbjct: 563 QR----MEQEAERRRQPQIKQEPE-------------SEEEEEEKQEKEEKREEPMEEEE 605 Query: 547 ERERSTSMR 555 E E+ ++ Sbjct: 606 EPEQKPCLK 614 >gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain containing B [Homo sapiens] Length = 546 Score = 162 bits (409), Expect = 1e-39 Identities = 99/297 (33%), Positives = 163/297 (54%), Gaps = 37/297 (12%) Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNRSRSRQKDRR 349 + R RS S RS RS S+SH R R+ + K R R ++ R+K+RR Sbjct: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR 316 Query: 350 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407 RS+S + +R +SR R + RSRS SRD++ D R++ +E+E+ E ER R ++R+ Sbjct: 317 RSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK------ENERGRRRDRDY 370 Query: 408 EKERGKNKDRDKEREKDREKDKE-KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 466 +KERG +R+KERE+ RE+ KE + R EK+H++D+D + ++ ++ ++EK S+ Sbjct: 371 DKERGN--EREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR- 427 Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRER-------------RRRRSRSSSRSPRTSK 513 R +++K R+ RS NA +RSRS S+E+ +R RS S R+ K Sbjct: 428 ---SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484 Query: 514 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 570 + KR+ S S + + K+R +RDH + + ++ R S +++ +EK KN Sbjct: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541 Score = 148 bits (373), Expect = 2e-35 Identities = 99/291 (34%), Positives = 162/291 (55%), Gaps = 32/291 (10%) Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT---REKIKEKERVK----EKDRE 396 R +RRRS+SP + S R R+SRSRSH R+ + RE +EKER + K+RE Sbjct: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312 Query: 397 KER----------EREKEREKEKERGKNKDRDKE---REKDREKDKEKDREREREKEHEK 443 KER ER + R +E+ R +++ RD++ R++DRE++KE +R R R+++++K Sbjct: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372 Query: 444 DRDKEKEKEQDKEKEREKDRSK--EIDEKR----KKDKKSRTPPR-SYNASRRSRSSSRE 496 +R E+EKE+++ +ER K++ E++EK+ K D++ R R S + SRS SRE Sbjct: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432 Query: 497 RRRR-RSRSSSRSPRTSKTIKRKSS--RSPSPRSRNKKDKKREKER-DHISERRERERST 552 R+ R RSRS + R+ K KSS ++ S NK+ + + R D + + ++RE S Sbjct: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP 492 Query: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 S KS KE+ K S K+ + + D S+ ++ + + +NK Sbjct: 493 SKEKSRKRSRSKERSHKRDHS-DSKDQSDKHDRRRSQSIEQESQEKQHKNK 542 Score = 110 bits (276), Expect = 3e-24 Identities = 74/275 (26%), Positives = 131/275 (47%), Gaps = 27/275 (9%) Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSN--------ERKGGRSRSHTRSKSRSSSKSH 323 + + ++R +E Q A E E + ER+ RSR RS+SRS + Sbjct: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347 Query: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383 RR R + + + R R R D+ R K+R +SRE R K + +R + Sbjct: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE----------RSKEQRSRGE 397 Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRD-KEREKDREKDKEKDREREREKEHE 442 ++EK+ ++KD + R+ +++ +KEK+ +++ R+ K R + R ++ K R R R KE Sbjct: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK-RSRSRSKEKS 456 Query: 443 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS 502 K K + ++K +R + S+ + +K KK P + +RSRS R +R S Sbjct: 457 ---SKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHS 513 Query: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK 537 S +S + R+ S+S S+ K+ K +++ Sbjct: 514 DSKDQSDKHD----RRRSQSIEQESQEKQHKNKDE 544 Score = 101 bits (252), Expect = 2e-21 Identities = 63/256 (24%), Positives = 116/256 (45%), Gaps = 21/256 (8%) Query: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKD--------REKEREREKEREKEKERGKNKDR 417 K+R R +D ++ E + ER + + R R R + +E + DR Sbjct: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293 Query: 418 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID--------- 468 + EREK+R++ + + +ERE+E+ + D+ E+ + + +ER + RS+ D Sbjct: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRD 353 Query: 469 -EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRS 527 E+ K++++ R R Y+ + R + RE+ R RSR S+ R+ ++ K + Sbjct: 354 REREKENERGRRRDRDYD---KERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDR 410 Query: 528 RNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587 R++ DK+ K+ S R RER R S + + + S K K +KE + Sbjct: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470 Query: 588 SKEVDDKDAPRTEENK 603 S+ E++K Sbjct: 471 SRSGSQGRTDSVEKSK 486 Score = 94.0 bits (232), Expect = 4e-19 Identities = 62/238 (26%), Positives = 113/238 (47%), Gaps = 14/238 (5%) Query: 375 DKRKDTR-EKIKE--KERVKEKDR--EKEREREKEREKEKERGKNKDRDKEREKDREKDK 429 D++ TR KIK+ KE +E DR E+ R R R R + R + ++ Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289 Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 DRE EREKE ++ + KE+E+++ + R DR E ++ +SR RS + SR Sbjct: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLE-----RRRSRSRERHRSRSRSRD 344 Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTI-KRKSSRSPSPRSRNKKDKKREKERDHISERRER 548 + R+R R R + + R R + K + + R R+++ K ++ R + E++ + Sbjct: 345 RKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404 Query: 549 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606 E R + RD K++ + + + +E++H S S+ + R++E +H Sbjct: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR---SRSRNAGKRSRSRSKEKSSKH 459 Score = 51.6 bits (122), Expect = 2e-06 Identities = 45/177 (25%), Positives = 77/177 (43%), Gaps = 17/177 (9%) Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501 +K+ D++ + K K+ K+ ++EID ++ ++SR+P RRS S R RR R Sbjct: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVER-RRSRSP-------RRSLSPRRSPRRSR 277 Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561 SRS R S + R+ R + ++ K+REKER RS S+ + R Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER---------RRSRSIDRGLERR 328 Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLS 618 + + S S D +E +++ R + + + GN + E S Sbjct: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385 Score = 44.3 bits (103), Expect = 3e-04 Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 1/108 (0%) Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313 + S NA + + + ++K E ++ + S KS +R+ S+ +R Sbjct: 439 SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498 Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361 +SRS +SH +R S SK +S H+R RS+ ++ + HK + ++ Sbjct: 499 KRSRSKERSH-KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545 >gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] Length = 1564 Score = 158 bits (399), Expect = 2e-38 Identities = 104/354 (29%), Positives = 180/354 (50%), Gaps = 42/354 (11%) Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352 I+ S SN +RS + R + + + R S R R ++ +R Sbjct: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK----- 407 SP + + ++ E + R R R D R + +ER +E++R++ERERE+ERE+ Sbjct: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE 702 Query: 408 -----EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE-QDKEKEREK 461 E+ER + ++R++E+E+DRE+D+++D +RERE+E E+DR+KE+E+E +++E+ERE+ Sbjct: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762 Query: 462 DRSKEIDEKRKKDK-----KSRTPPRSYNASRRSRSSSRERR--------------RRRS 502 +R +E + +R++++ K R R + + R RE+R R+S Sbjct: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822 Query: 503 RSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE--RRERERSTSMRKS 557 + R SP ++ KR+ SP + N D K EK R +S+ R + RS S Sbjct: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR-LLSQVVRPQESRSLSPSHL 881 Query: 558 SNDRDGKEKLE------KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605 + DR G+ K E K S+ E++ KE SSV K+ + + + + Q Sbjct: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935 Score = 151 bits (381), Expect = 2e-36 Identities = 97/350 (27%), Positives = 176/350 (50%), Gaps = 23/350 (6%) Query: 295 PESGKSNER------KGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348 PE G R S H ++RSS R ++ ++R + R + Sbjct: 571 PEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERD 630 Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 408 RR +R S R + R+ RD+R++ R + +R E+ RE++RERE++RE+E Sbjct: 631 RRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERE 690 Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468 +ER + +DR++E+E++ E+++ ++REREREKE +++RD++++ ++++E+ERE+DR KE + Sbjct: 691 RERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERE 750 Query: 469 EKRKKDKKSRTPPRSYNASR-----RSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSS 520 +R++ ++ R R R R+R +ER R+R + R R K + + Sbjct: 751 REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810 Query: 521 RSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD----GKEKLEKNSTSLKE 576 R+P +K KKR + S R+ +R R+ S D D G +K EK+ + Sbjct: 811 RNPRDGHDERKSKKRYRNEGSPSPRQSPKR---RREHSPDSDAYNSGDDKNEKHRLLSQV 867 Query: 577 KEHNKEPDSSVSKEVDDKDAPRTEENK--IQHNGNCQLNEENLSTKTEAV 624 + S S +D+ EE++ + + + E+ L K +V Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSV 917 Score = 130 bits (326), Expect = 5e-30 Identities = 91/331 (27%), Positives = 165/331 (49%), Gaps = 26/331 (7%) Query: 301 NERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRS 359 ++R+ R+R R + R + R R+R + + + R R R+R+++R R K ++R Sbjct: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728 Query: 360 KSRE--RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417 + R+ R + R R R+K ++ + +E+ER +E++RE+ERERE+ER +E +D+ Sbjct: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE------RDK 782 Query: 418 DKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476 ++ER++D +KDK +D RE+ +E +DR+ ++ K K+R ++ + K ++ Sbjct: 783 ERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR 842 Query: 477 SRTPPR-SYNA----SRRSRSSSRERRRRRSRSSSRSPRTS------KTIKRKSSRSPSP 525 +P +YN+ + + R S+ R + SRS S S T K RK R S Sbjct: 843 EHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESS 902 Query: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585 R R ++ + +EK +R + E S R + D G + E TS + + NK+ Sbjct: 903 R-RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961 Query: 586 SVSKEVDDKDAPRTEENKIQHNGNCQLNEEN 616 K + K E++ GN + E+ Sbjct: 962 IQKKPIKKK----KEDDVGIERGNIETTSED 988 Score = 123 bits (309), Expect = 4e-28 Identities = 92/360 (25%), Positives = 175/360 (48%), Gaps = 37/360 (10%) Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGG---RSRSHTRSKSRSSSKSHSRRKR 328 ++E+ + + +E++ + ++ +R+G R +SRS ++H R + Sbjct: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538 Query: 329 SQSKHRSRSHNRSRSRQKD----RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----DT 380 S+++ R+ S N SRS ++ R R + P SR R S+ SHS + +T Sbjct: 539 SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598 Query: 381 REKIKEKERVKEKD-REKEREREKEREK-EKERGKNKDRDK-------------EREKD- 424 R E++R E+D R++ R+ ER E++R N++RD+ E E+D Sbjct: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE 658 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 R +++ DR +R E ++RD+E+E+++++E+ERE++R +E +++R+ +++ Sbjct: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERA------ 712 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544 R R R+R R R R R + R+ R R R +++++RE+ER+ E Sbjct: 713 REREREREKERDRERDRDRDHDRERERERERDREKERE---REREERERERERERERERE 769 Query: 545 R-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 R RERER+ K + E +K +EK D + D++ + + N+ Sbjct: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829 Score = 100 bits (250), Expect = 3e-21 Identities = 77/253 (30%), Positives = 128/253 (50%), Gaps = 35/253 (13%) Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDR-------RRSKSPHKKR- 358 +RSHT + RS S + R R R H+ SR R+K + R+S+ KR Sbjct: 1198 NRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRG 1257 Query: 359 ----SKSRERRKSRSRS------------HSRDKRKDTREKIKEKERVKEKDREKERERE 402 S S +R+ SRS S HSR D+R++++E++R E DRE+ERER Sbjct: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY-EHDRERERERR 1316 Query: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462 R++E +R + D+D R +DR++ +E++RERER+K + DR++E+ E++R++D Sbjct: 1317 DTRQREWDR--DADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374 Query: 463 RSKEIDE------KRKKDKKSRTPPRSY-NASRRSRSSSRERRRRRSRSSSRSPRTSKTI 515 R + + KR + K R + SR S + +ER + S T+K+ Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434 Query: 516 KRKSSRSPSPRSR 528 + +S + S+ Sbjct: 1435 RTESLEAGDDESK 1447 Score = 98.2 bits (243), Expect = 2e-20 Identities = 76/318 (23%), Positives = 135/318 (42%), Gaps = 27/318 (8%) Query: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR--- 325 +A ++ E R RE + E E + ER+ R R R K R + R Sbjct: 675 RARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734 Query: 326 RKRSQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384 R+R + + R R R R R+ ++R R + ++R + RER ++R R R++++D Sbjct: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW---- 790 Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKEH 441 ++KD+ ++ REK E ++R D+ + K R +++ R+ R +EH Sbjct: 791 ------EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREH 844 Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501 D D + EK R + E R P R+ R +R+ R Sbjct: 845 SPDSDAYNSGDDKNEKHRLLSQVVRPQESRS------LSPSHLTEDRQGRWKEEDRKPER 898 Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSND 560 SS R + +K K S R + + + R + +D I + +R TS R + ++ Sbjct: 899 KESSRR--YEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-AHDE 955 Query: 561 RDGKEKLEKNSTSLKEKE 578 K K++K K+++ Sbjct: 956 NKKKAKIQKKPIKKKKED 973 Score = 94.4 bits (233), Expect = 3e-19 Identities = 81/321 (25%), Positives = 132/321 (41%), Gaps = 39/321 (12%) Query: 263 PPEMTPQAAA-----KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317 PP P+ A KE +V R+ E + GK R R R R K R Sbjct: 266 PPPPIPEDIALGKKYKEKYKVKDRIEE---------KTRDGKDRGRDFERQREK-RDKPR 315 Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377 S+S + S+H S S S+S +R S SP +KR+ S +++ + R Sbjct: 316 STSPAGQHHSPISSRHHSSS---SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372 Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER------EKDREKDKEK 431 + +R + R + REK R + ++ DR ER ++DREKD + Sbjct: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432 Query: 432 DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSR 491 E+E+E+D+ ++ D+E +DR D + +D++ R SR R Sbjct: 433 ------EREYEQDQSSSRDHRDDREPRDGRDRR---DARDTRDRRELRDSRDMRDSREMR 483 Query: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER------ 545 SR+ + R SRS R + + + R + ++ R R+H+ E Sbjct: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEI 543 Query: 546 RERERSTSMRKSSNDRDGKEK 566 R R+ S + NDR G+ + Sbjct: 544 RNESRNESRSEIRNDRMGRSR 564 Score = 90.5 bits (223), Expect = 4e-18 Identities = 80/347 (23%), Positives = 155/347 (44%), Gaps = 47/347 (13%) Query: 300 SNERKGGRSRSHTRS--KSRSSSKSHSRR-----KRSQSKHRSRSHNRSRSRQKDRRRSK 352 S+ + G + H+ S + R+ S S+ R +RS S + S S + S R++ R + Sbjct: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS-SPQRKQSPPRHR 392 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 412 SP +++ + R S+S ++R+DTR K +++E+ ++RE E+++ R+ +R Sbjct: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGK-RDREKDSREEREYEQDQSSSRDHRDDRE 451 Query: 413 KNKDRDKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471 RD+ +D R++ + +D R+ +D ++ ++ +D R + + ++ Sbjct: 452 PRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE 511 Query: 472 KKD--KKSRTPP---RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526 +D +K T P RSY + SSR R SR+ SRS + + R R P Sbjct: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP 571 Query: 527 SRNKKDKKREK---------------------ERDHISER--RERERSTSMRKSSNDRDG 563 + + + + ERD ER R++ R +S + +RD Sbjct: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR 631 Query: 564 KEKLEKN---STSLKEKEHNKEPDSSVSKE------VDDKDAPRTEE 601 ++ E++ S+ ++ + N E + +E VDD+ R E Sbjct: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARE 678 Score = 87.8 bits (216), Expect = 3e-17 Identities = 87/399 (21%), Positives = 155/399 (38%), Gaps = 94/399 (23%) Query: 297 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQ----------- 345 + +S++R+ R R TR K S R+ Q + SR H R + Sbjct: 406 TSQSHDRRHER-REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDT 464 Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR-------------KDTREKIKEKERVKE 392 +DRR + R R SR SRD R ++ R+ ++++ E Sbjct: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524 Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER----------------- 435 + R R +E E + +N+ R++ R + R + R R Sbjct: 525 ESRSYGRNHLRE-ESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQI 583 Query: 436 --------------------EREKEHEKD-RDKEKEK-------EQDKEKEREKDR---- 463 ER++ E+D RD+ ++ E+D+ RE+D+ Sbjct: 584 DSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSS 643 Query: 464 ---------SKEIDEKRKKDKKSRTPPRSYNASR---RSRSSSRERRRRRSRSSSRSPRT 511 E DE+R++ + R R +R R R RER R R R R Sbjct: 644 PIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREK 703 Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-----RERERSTSMRKSSNDRDGKEK 566 + ++R+ +R ++D++R+++RDH ER R+RE+ + +R+ + + Sbjct: 704 ERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERE 763 Query: 567 LEKNSTSLKEKEHNKEPDSSVSKEVD--DKDAPRTEENK 603 E+ +E+E +E D ++ D DKD R + + Sbjct: 764 RERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802 Score = 77.0 bits (188), Expect = 5e-14 Identities = 87/339 (25%), Positives = 139/339 (41%), Gaps = 41/339 (12%) Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS--KSP---HKKRSKSRERRKSRSRSHSR 374 S S S RK S+S R S S + +KDR+ S SP ++ SK+ + +K R+ S Sbjct: 207 SPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSP 266 Query: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDR 433 E I ++ KEK + K+R EK R+ K+RG++ +R +E R+K R Sbjct: 267 PP--PIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323 Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK-----KDKKSRTPPRSYNASR 488 H + Q + R+ +R + S P S ++ + Sbjct: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQ 383 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR--NKKDKKREKE-------- 538 R +S R R R + RTS++ R+ R R + +KD + E+E Sbjct: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443 Query: 539 RDHISERRERE-------RSTSMRKSSND-RDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590 RDH +R R+ R T R+ D RD ++ E S KE DS +++ Sbjct: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503 Query: 591 VDD------KDAPRTEENKIQHN---GNCQLNEENLSTK 620 D +D R E+ + + G L EE+ T+ Sbjct: 504 AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542 Score = 72.8 bits (177), Expect = 9e-13 Identities = 54/200 (27%), Positives = 93/200 (46%), Gaps = 20/200 (10%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR----------RKRSQSKH-RSRSHNRSR 342 EP S++R+ RS S RS S + HSR ++R + +H R R R Sbjct: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRD 1317 Query: 343 SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE 402 +RQ++ R R++ R+R + R R RDKR+D +E+ER+ E++R+R+ Sbjct: 1318 TRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLD---RERERLISDSVERDRDRD 1374 Query: 403 KEREKEKERGKNKDR-----DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK 457 ++R E + ++ R + E E+D E ++E+ +KD + E+ + Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER-MDKDLGSVQGFEETNKS 1433 Query: 458 EREKDRSKEIDEKRKKDKKS 477 ER + DE + D S Sbjct: 1434 ERTESLEAGDDESKLDDAHS 1453 Score = 63.5 bits (153), Expect = 5e-10 Identities = 76/289 (26%), Positives = 126/289 (43%), Gaps = 24/289 (8%) Query: 330 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKE 388 + K S ++ RS R R + +K++ E +K + S RK++ R + +EKE Sbjct: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125 Query: 389 RVKEKDREKEREREKER-EKEKERGKNKDRDKEREKDREKDKEKDR---EREREKEHEKD 444 +K +E+ E E+E E E R + + D + E E R +RE K +++ Sbjct: 126 DIKIT-KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN 184 Query: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504 +K +E KE E RSK + K S++P R +S +S S+S++ R+ + S Sbjct: 185 MEKREEIIIKKEVSPEVVRSK-LSPSPSLRKSSKSPKR--KSSPKSSSASKKDRKTSAVS 241 Query: 505 SS--RSPRTSKT--IKRKSSRSPSPR-------SRNKKDKKREKERDHISER----RERE 549 S R SKT K+K R+PSP + KK K++ K +D I E+ ++R Sbjct: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG 301 Query: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598 R ++ D+ S H+ S S +PR Sbjct: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR 350 Score = 57.8 bits (138), Expect = 3e-08 Identities = 84/397 (21%), Positives = 144/397 (36%), Gaps = 108/397 (27%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 +ELE R RE + E + + ++R+ R R R K R + R+R + + Sbjct: 705 RELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERER 764 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHK-----------KRSKSRERRKSRSRSHSRDKRK--- 378 R R R R R ++R + + + +R K E R+ R+ D+RK Sbjct: 765 ERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKK 824 Query: 379 -------------------------------DTREK-------IKEKE------------ 388 D EK ++ +E Sbjct: 825 RYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTED 884 Query: 389 ---RVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKD-----------------REK 427 R KE+DR+ ER+ R +E+E + K DK+RE+ + + Sbjct: 885 RQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSE 944 Query: 428 DKE-KDREREREKEHEKDRDK--EKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 D+E DR + K+ K + K +K+KE D ER + D + KK + Sbjct: 945 DRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQ------ 998 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE--KERDHI 542 + S E++R++S+ S + K R P K++ E ++ I Sbjct: 999 ------KKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI 1052 Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579 E +++ T+ S D D ++ T + E EH Sbjct: 1053 LEDSQKKEDTAFSDWS-DEDVPDR-----TEVTEAEH 1083 Score = 42.0 bits (97), Expect = 0.002 Identities = 46/242 (19%), Positives = 87/242 (35%), Gaps = 39/242 (16%) Query: 401 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 460 R K R + RE+ + K ++ D E ++ E KE + + +E+E Sbjct: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125 Query: 461 -----KDRSKEIDEKRKKDKKSRTPP-----------------RSYNASRRSRSSSRERR 498 K+R+ E +E+ + + +R + R +E Sbjct: 126 DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENM 185 Query: 499 RRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST------ 552 +R + + + ++ K S SPS R +K K++ + + +++R+ S Sbjct: 186 EKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL 245 Query: 553 SMRKSSNDRDGKEK-----------LEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601 +++S K+K E + K KE K D K D KD R E Sbjct: 246 DQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFE 305 Query: 602 NK 603 + Sbjct: 306 RQ 307 Score = 40.0 bits (92), Expect = 0.006 Identities = 73/380 (19%), Positives = 127/380 (33%), Gaps = 51/380 (13%) Query: 261 VKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSS 320 + P +T + EE K R+ S E + K + R T S Sbjct: 876 LSPSHLTEDRQGRWKEEDRKPERKESS---RRYEEQELKEKVSSVDKQREQTEILESSRM 932 Query: 321 KSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSR---ERRKSRSRSHSRD-- 375 ++ QS+ R S +K + K P KK+ + ER + S Sbjct: 933 RAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVF 992 Query: 376 -KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR- 433 +K ++K EK+R K K + E ++ +K+RG +E+ E K+ Sbjct: 993 SPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGI 1052 Query: 434 -EREREKEHEKDRDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPP--------- 481 E ++KE D E D+ + E E + S PP Sbjct: 1053 LEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATA 1112 Query: 482 ---------------RSYNASRRSRSSS-------------RERRRRRSRSSSRSPRTSK 513 S++ S + S+S + R+ R+ T Sbjct: 1113 TTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPH 1172 Query: 514 -TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST 572 TI+ R P + R+ R H S R + S +S +D+ G++++ + + Sbjct: 1173 VTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGS 1232 Query: 573 SLKEKEHNKEPDSSVSKEVD 592 +EK + E +D Sbjct: 1233 RDREKTKSLEITGERKSRID 1252 >gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] Length = 715 Score = 151 bits (381), Expect = 2e-36 Identities = 111/364 (30%), Positives = 176/364 (48%), Gaps = 44/364 (12%) Query: 299 KSNERKG--------GRSRSHTRSKSRSSSKSHSRRK-----RSQSKHRSRSHNRSRSRQ 345 +S RKG +SRSH++ KS++ S++ R + R+ SK RS SH+RS S++ Sbjct: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374 Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKE 404 +D R S SP K+ +S+ ++ R HSR + + R++ + + K +DR + R K Sbjct: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA 434 Query: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKE------KE 458 R+ + R K RD+ R + K ++ R R K ++ R + KE+D KE Sbjct: 435 RDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKE 494 Query: 459 REKDRSKEIDEKRK-KDKKSRTPPRSYNASRRSRSSSRERRRR--------RSRSSSRSP 509 R+ RS+ ++R+ + +S + R + RRSRS S+ER+RR R RS SRSP Sbjct: 495 RDHRRSRSPSKERQCRQSRSSSKERDH---RRSRSPSKERQRRQSRSPNKERDRSQSRSP 551 Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDH-----ISERRERERSTSMRKSSN----D 560 S+ + + SRSPS ++ + KER+ SE R+ RS S K S Sbjct: 552 --SEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609 Query: 561 RDGKEKLEKNS-TSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 619 KEK S T KE H++ SS + PR+ + K L++ + Sbjct: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669 Query: 620 KTEA 623 KT + Sbjct: 670 KTSS 673 Score = 135 bits (341), Expect = 9e-32 Identities = 101/337 (29%), Positives = 172/337 (51%), Gaps = 40/337 (11%) Query: 290 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 349 S++ ESG+S + R H+RS+S + ++ SR RS K R RS +RS ++ +D Sbjct: 380 SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSR-SRSPYKARDRSRSRSPNKARDCS 438 Query: 350 RSKSPHKKRSKSRERRKSRSRSHSRDK-----RKDTREKIKEKER--------VKEKDRE 396 RS+SP+K R +SR R +++R HSR + R +R + KER KE+D Sbjct: 439 RSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHR 498 Query: 397 KEREREKEREKEKERGKNKDRD----------KEREKDREKDKEKDRERER----EKEHE 442 + R KER+ + R +K+RD ++R + R +KE+DR + R E+EH Sbjct: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR 558 Query: 443 KDRDKEKEKEQDK----EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR 498 + R KE+++ + KERE+ +S+ E+R +SR+P + S R R+SS+E+ Sbjct: 559 QSRSPSKERDRRRWRSPSKERERRQSRSSSEER-DHSRSRSPNKQSGYS-RPRASSKEKA 616 Query: 499 RRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556 RSR+ S+ + S+T ++S S S R+ K+ +S+ R +++S Sbjct: 617 HSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSP 676 Query: 557 SSNDRDG----KEKLEKNSTSLKEKEHNKEPDSSVSK 589 S+ G ++ + ++T+ K + SS SK Sbjct: 677 STFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713 Score = 134 bits (338), Expect = 2e-31 Identities = 107/357 (29%), Positives = 164/357 (45%), Gaps = 25/357 (7%) Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313 N S N + ++++KE + +S S + P + + R +++ R Sbjct: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR 413 Query: 314 SKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR--SKSRERRKSRSR 370 S+SRS K+ R R RS +K R S +RS + +DR RS+SP+K R S+SR K+R R Sbjct: 414 SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDR 473 Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430 S SR K+ R+ + KE+D + R KER+ + R +K+RD R R KE Sbjct: 474 SRSRSPSKE-RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR--SRSPSKE 530 Query: 431 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 490 + R + R E+DR + + +++E + + SKE D +R + P R+S Sbjct: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS------PSKERERRQS 584 Query: 491 RSSSRERRRRRSRSSSRS-----PRTSKTIKRKS-SRSPSPRSRNKKDKKREKERDHISE 544 RSSS ER RSRS ++ PR S K S SR+PS + + + KE D Sbjct: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD--PS 642 Query: 545 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE--PDSSVSKEVDDKDAPRT 599 + RS ++S L +N T K H+ P + DD A T Sbjct: 643 QSTVPRSPDWKRSPT---RTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADAT 696 Score = 129 bits (325), Expect = 6e-30 Identities = 94/307 (30%), Positives = 153/307 (49%), Gaps = 30/307 (9%) Query: 303 RKGGRSRSHTRSKSRSSSKSHSR-----RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 357 R G + R+H+R +S S ++HSR RK S+ S +RS S+ K + +S++P + Sbjct: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350 Query: 358 RSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415 RS SR K RS SHSR K+ + R KE R + K+R+ + R NK Sbjct: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR-KESGRSQSGSPNKQRDHSRSRSPNK 409 Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 475 RD+ R + K +++ R R K + R + K +D+ + R +++++ R +K Sbjct: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469 Query: 476 -----KSRTPPRSYNASRRSRSSSRERRRRRSRSSSR------SPRTSKTIKRKSSRSPS 524 +SR+P + + S+ S S+ER RRSRS S+ S +SK + SRSPS Sbjct: 470 ARDRSRSRSPSKERDHSQLG-SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS 528 Query: 525 PRSRNKKDKKREKERDHI-----SERRERERSTSMRKSSNDR----DGKEKLEKNS-TSL 574 + ++ + KERD SE RE +S S K + R KE+ + S +S Sbjct: 529 KERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS 588 Query: 575 KEKEHNK 581 +E++H++ Sbjct: 589 EERDHSR 595 Score = 112 bits (281), Expect = 8e-25 Identities = 90/329 (27%), Positives = 152/329 (46%), Gaps = 34/329 (10%) Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHS-----RRKRSQSKHRSRSHNRSRSRQKDRRR 350 E S R +S+ ++ +RS +SHS RR RS S+ R+ S RS S +++ R Sbjct: 254 EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR 313 Query: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 410 ++S +K S+ R S+SRSHS+ K ++ + + + R R KE Sbjct: 314 ARSRTRKGILSQMGRHSQSRSHSKGKSQN-----------QSRTPRRGRSHNWSRNPSKE 362 Query: 411 RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470 R + R +E+D +E R + ++ ++ + + K R++ RS+ K Sbjct: 363 RSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS-PYK 421 Query: 471 RKKDKKSRTPPRSYNASR-----RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525 + +SR+P ++ + SR ++R SR R ++R SRS +K R SRSPS Sbjct: 422 ARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSK 481 Query: 526 RSRNKKDKKREKERDHISER---RERERSTSMRKSSNDRD-------GKEKLEKNSTS-L 574 + + KERDH R +ER+ S R SS +RD KE+ + S S Sbjct: 482 ERDHSQLGSPSKERDHRRSRSPSKERQCRQS-RSSSKERDHRRSRSPSKERQRRQSRSPN 540 Query: 575 KEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 KE++ ++ S +E +P E ++ Sbjct: 541 KERDRSQSRSPSEEREHRQSRSPSKERDR 569 Score = 72.0 bits (175), Expect = 2e-12 Identities = 86/354 (24%), Positives = 139/354 (39%), Gaps = 20/354 (5%) Query: 266 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 325 + P A VM + ++ S + + R R RS R+ SR S+ + + Sbjct: 44 LVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRS--RVRSKARTPSRVSTDTRTS 101 Query: 326 R--KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383 + K S + R SR R RR S+S KRS SR R R+H +R + Sbjct: 102 KASKASDVRCHQRRGTHSRGRTPGRRGSRS--SKRSPSRASTPGRIRTHGARPGMASRVR 159 Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-----DREKDKEKDRERERE 438 ++ + + R R RE+ + +N + R R + + Sbjct: 160 TPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKC 219 Query: 439 KEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKD---KKSRTPPRSYN-ASRRSR-- 491 + KEK R+ K + I R+K + + +SYN AS RSR Sbjct: 220 QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ 279 Query: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 551 S S+ R RRSRS S+ RT ++ S + R+R++ K + S+ R + Sbjct: 280 SHSQSRSPRRSRSGSQK-RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338 Query: 552 TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605 S +S R G+ + S KE+ H+ SS ++ +PR E + Q Sbjct: 339 KSQNQSRTPRRGRSHNWSRNPS-KERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391 >gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] Length = 290 Score = 149 bits (376), Expect = 8e-36 Identities = 81/259 (31%), Positives = 143/259 (55%), Gaps = 20/259 (7%) Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RKSRSRSHSRDKRKDTREKIKEKER 389 S+ R S RS + + R + R+R R+ + RD+++D + KEKE Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKET 109 Query: 390 VKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449 + +DREK+ E E++RE+EK++G+ ++RD+ RE++R++D+EK+RER+ EK+ + R+ E Sbjct: 110 NRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETET 169 Query: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509 E+E+D+E+E++K+R E D R++D + R R + RER R+R + R Sbjct: 170 ERERDREREKQKERETERDRDRQRDTEKE----------RERQTDRERDRQRKTQTERQR 219 Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEK 569 T + +R++ R R ++D+ R KERD RER+R +K KE+ EK Sbjct: 220 ETDREGERETDR----RRERQRDRDRGKERD-----RERDRKEERKKERKKERKKERKEK 270 Query: 570 NSTSLKEKEHNKEPDSSVS 588 + ++ ++ +S Sbjct: 271 KKEEKRREDKKRKWGEGIS 289 Score = 149 bits (376), Expect = 8e-36 Identities = 84/264 (31%), Positives = 147/264 (55%), Gaps = 30/264 (11%) Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 373 S+ R S+ R H+ + R R++DR R K+ K R+R + R R Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGD-DRQRERDRVREKT-----EKERDRDRKRDRERR 103 Query: 374 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR 433 R +++ R + +EK+ E+DRE RE++K RE+E++RG+ ++RD++REK+RE+ EKDR Sbjct: 104 RKEKETNRNRDREKQTEIERDRE--REKQKGRERERDRGRERERDRDREKERERQTEKDR 161 Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493 + +RE E E++RD+E+EK++++E ER++DR ++ +++R+ R + Sbjct: 162 DGQRETETERERDREREKQKERETERDRDRQRDTEKERE------------------RQT 203 Query: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553 RER R+R + R T + +R++ R R ++D+ R KERD +R+E + Sbjct: 204 DRERDRQRKTQTERQRETDREGERETDR----RRERQRDRDRGKERDRERDRKEERKKER 259 Query: 554 MRKSSNDRDGKEKLEKNSTSLKEK 577 ++ +R K+K EK K K Sbjct: 260 KKERKKERKEKKKEEKRREDKKRK 283 Score = 140 bits (353), Expect = 3e-33 Identities = 64/214 (29%), Positives = 125/214 (58%), Gaps = 2/214 (0%) Query: 289 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348 + A + G +R+ R R T K R + R +R + K +R+ +R + + +R Sbjct: 65 LGQAHKDADGDDRQRERDRVREKTE-KERDRDRKRDRERRRKEKETNRNRDREKQTEIER 123 Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKEREREKEREK 407 R + K R + R+R + R R R+K ++ + EK ++ +R E +RE++REREK++E+ Sbjct: 124 DREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKER 183 Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI 467 E ER +++ RD E+E++R+ D+E+DR+R+ + E +++ D+E E+E D+ +ER++DR + Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGK 243 Query: 468 DEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501 + R++D+K ++ R ++ +RR Sbjct: 244 ERDRERDRKEERKKERKKERKKERKEKKKEEKRR 277 Score = 140 bits (352), Expect = 5e-33 Identities = 79/247 (31%), Positives = 130/247 (52%), Gaps = 36/247 (14%) Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH---NRSRSRQKDRRRSKSP 354 G++++ G R R + R ++ R R + + R R NR+R R+K + Sbjct: 66 GQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDR 125 Query: 355 HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414 +++ K RER + R R RD R++ KE+ER EKDR+ +RE E ERE+++ER K Sbjct: 126 EREKQKGRERERDRGRERERD-----RDREKERERQTEKDRDGQRETETERERDREREKQ 180 Query: 415 KDRDKEREKDREKDKEKDREREREKEHEKDR--DKEKEKEQDKEKEREKDRSKEIDEKRK 472 K+R+ ER++DR++D EK+RER+ ++E ++ R E+++E D+E ERE DR +E Sbjct: 181 KERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRE------ 234 Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532 +R R +ER R R R R +RK R + + K++ Sbjct: 235 --------------RQRDRDRGKERDRERDRKEERKK------ERKKERKKERKEKKKEE 274 Query: 533 KKREKER 539 K+RE ++ Sbjct: 275 KRREDKK 281 Score = 133 bits (335), Expect = 4e-31 Identities = 72/242 (29%), Positives = 129/242 (53%), Gaps = 20/242 (8%) Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358 + + R G ++H + + R + K R R R R R R K R Sbjct: 57 QESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRER-----RRKEKETNR 111 Query: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418 ++ RE++ R R+K+K RE+ +++ R +E+DR++E+ER ER+ EK+R ++ + Sbjct: 112 NRDREKQTEIERDREREKQKG-RERERDRGRERERDRDREKER--ERQTEKDRDGQRETE 168 Query: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSR 478 ERE+DRE++K+K+RE ER+++ ++D +KE+E++ D+E++R+ R + + +R+ D++ Sbjct: 169 TERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQ--RKTQTERQRETDRE-- 224 Query: 479 TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKE 538 R RER+R R R R + +RK R + K+ KK EK Sbjct: 225 --------GERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKR 276 Query: 539 RD 540 R+ Sbjct: 277 RE 278 Score = 132 bits (332), Expect = 1e-30 Identities = 65/199 (32%), Positives = 125/199 (62%), Gaps = 13/199 (6%) Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-SKHRSRSHNRSRSRQKDRRRSKSP 354 E + +RK R R R K + ++++ R K+++ + R R + R R++DR R + Sbjct: 89 EKERDRDRKRDRER---RRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERER 145 Query: 355 HKKRSKSRERRKSRSRSHSRD---KRKDTREKIKEKERVKEKDR------EKEREREKER 405 + R K RER+ + R R+ +R+ RE+ K+KER E+DR EKERER+ +R Sbjct: 146 DRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDR 205 Query: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465 E++++R +R +E +++ E++ ++ RER+R+++ K+RD+E++++++++KER+K+R K Sbjct: 206 ERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKK 265 Query: 466 EIDEKRKKDKKSRTPPRSY 484 E EK+K++K+ R + Sbjct: 266 ERKEKKKEEKRREDKKRKW 284 Score = 121 bits (304), Expect = 2e-27 Identities = 68/222 (30%), Positives = 123/222 (55%), Gaps = 14/222 (6%) Query: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 435 K D ++ +E++RV+EK EKER+R+++R++E+ R KE+E +R +D+EK E Sbjct: 70 KDADGDDRQRERDRVREKT-EKERDRDRKRDRERRR-------KEKETNRNRDREKQTEI 121 Query: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495 ER++E EK + +E+E+++ +E+ER++DR KE + + +KD+ + + R R + Sbjct: 122 ERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQK 181 Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD---HISERRERERST 552 ER R R R T K +R++ R + + + +++RE +R+ RRER+R Sbjct: 182 ERETERDRDRQRD--TEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDR 239 Query: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594 R DR+ K E+ KE++ ++ K +DK Sbjct: 240 D-RGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDK 280 Score = 115 bits (287), Expect = 2e-25 Identities = 62/193 (32%), Positives = 111/193 (57%), Gaps = 18/193 (9%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 KE E R RE Q+ E E + E++ GR R R + R R R + K Sbjct: 105 KEKETNRNRDREKQT------EIERDREREKQKGRERERDRGRERE-------RDRDREK 151 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 R R + R Q++ + ++R K +ER R R RD K+ RE+ ++ER ++ Sbjct: 152 ERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKE-RERQTDRERDRQ 210 Query: 393 K----DREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 448 + +R++E +RE ERE ++ R + +DRD+ +E+DRE+D++++R++ER+KE +K+R ++ Sbjct: 211 RKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEK 270 Query: 449 KEKEQDKEKEREK 461 K++E+ +E ++ K Sbjct: 271 KKEEKRREDKKRK 283 Score = 94.7 bits (234), Expect = 2e-19 Identities = 58/193 (30%), Positives = 106/193 (54%), Gaps = 10/193 (5%) Query: 418 DKEREKDREKDK-EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475 D++RE+DR ++K EK+R+R+R+++ E+ R KEKE ++ ++REK E D +R+K K Sbjct: 76 DRQRERDRVREKTEKERDRDRKRDRERRR---KEKETNRNRDREKQTEIERDREREKQKG 132 Query: 476 KSRTPPRSYNASR-RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 534 + R R R R R RER+ + R R T + R+ + + +D++ Sbjct: 133 RERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQ 192 Query: 535 R--EKERDHISER-RERERST-SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590 R EKER+ ++R R+R+R T + R+ DR+G+ + ++ ++++ KE D ++ Sbjct: 193 RDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRK 252 Query: 591 VDDKDAPRTEENK 603 + K + E K Sbjct: 253 EERKKERKKERKK 265 Score = 67.4 bits (163), Expect = 4e-11 Identities = 48/206 (23%), Positives = 94/206 (45%), Gaps = 25/206 (12%) Query: 423 KDREKDKEKDREREREKEHEKDRDKEKEKEQDK-----EKEREKDRSKEIDEKRKKDKKS 477 + R +E R + H+ ++++E+D+ EKER++DR ++ + +RK+ + + Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETN 110 Query: 478 RTPPRSYNAS-----RRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532 R R R + RER R R R R K +R++ + + + + Sbjct: 111 RNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETE 170 Query: 533 KKREKERDHISER-----RERERSTSM---RKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584 ++R++ER+ ER R+R+R T R++ +RD + K + ++E +E D Sbjct: 171 RERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETD 230 Query: 585 SSVSKEVD-------DKDAPRTEENK 603 ++ D D++ R EE K Sbjct: 231 RRRERQRDRDRGKERDRERDRKEERK 256 Score = 67.4 bits (163), Expect = 4e-11 Identities = 39/141 (27%), Positives = 73/141 (51%), Gaps = 5/141 (3%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 KE E ++ R+ Q E E + E++ R R + R + K R+ + + Sbjct: 151 KERERQTEKDRDGQR--ETETERERDREREKQKERETERDRDRQRDTEKERERQT-DRER 207 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 R R R R+ DR + ++R + R+R + + R RD RK+ R+K ++KER KE Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERD-RKEERKKERKKERKKE 266 Query: 393 KDREKEREREKEREKEKERGK 413 + +EK++E ++ +K+++ G+ Sbjct: 267 R-KEKKKEEKRREDKKRKWGE 286 Score = 53.1 bits (126), Expect = 7e-07 Identities = 41/153 (26%), Positives = 70/153 (45%), Gaps = 9/153 (5%) Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK-K 531 KD R + R R+R R+R R R + + + + ++ R R + K Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129 Query: 532 DKKREKERDHISER-RERERSTSM-RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589 K RE+ERD ER R+R+R R++ DRDG+ + E +E+E KE ++ Sbjct: 130 QKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETE--- 186 Query: 590 EVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622 D+D R E + + + + + + T+TE Sbjct: 187 --RDRDRQRDTEKERERQTDRERDRQR-KTQTE 216 Score = 35.0 bits (79), Expect = 0.21 Identities = 29/121 (23%), Positives = 52/121 (42%), Gaps = 11/121 (9%) Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKR---------EKERDHISER-RERERSTSMR 555 SR S+ R + + + D++R EKERD +R RER R Sbjct: 50 SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKET 109 Query: 556 KSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD-DKDAPRTEENKIQHNGNCQLNE 614 + DR+ + ++E++ K+K +E D +E D D++ R + + +G + Sbjct: 110 NRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETET 169 Query: 615 E 615 E Sbjct: 170 E 170 >gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] Length = 494 Score = 145 bits (367), Expect = 8e-35 Identities = 100/317 (31%), Positives = 160/317 (50%), Gaps = 24/317 (7%) Query: 293 IEPESGKSNERKGGRSRSHTRSKSRS--SSKSHSRR---KRSQSKHRSRSHNRSRSRQKD 347 +E + G R RSRSH+RS+SRS S KS SR K S SK RSRS + SRSR K Sbjct: 173 VEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232 Query: 348 RRRSKS---PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD---REKERER 401 R RS+S K++S+S + KSRSRSHS K + ++ K + +E+++ D + K R Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSR-SKSKDQAEEKIQNNDNVGKPKSRSP 291 Query: 402 EKEREKEKERGKNKDRDKEREK--------DREKDKEKDREREREKEHEKDRDKEKEKEQ 453 + + K K R ++++R E EK +EK + R R R K + R + + K + Sbjct: 292 SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSK 351 Query: 454 DKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSK 513 DK K R++ R + R + K R+ R ++ SS ++++ RS SRSP S Sbjct: 352 DKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSV 411 Query: 514 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS-T 572 + +R+ ++S S + + + + E R R RS S K + + + + + S T Sbjct: 412 SKEREHAKSESSQREGRGESENAGTN---QETRSRSRSNSKSKPNLPSESRSRSKSASKT 468 Query: 573 SLKEKEHNKEPDSSVSK 589 + K ++ S S+ Sbjct: 469 RSRSKSRSRSASRSPSR 485 Score = 125 bits (314), Expect = 1e-28 Identities = 112/403 (27%), Positives = 189/403 (46%), Gaps = 69/403 (17%) Query: 182 RTVY---VGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDETQPTRFAFVEFADQNSVPRA 238 RT Y V NL+S+ + D L ++ +Q GEV + A +EF + + RA Sbjct: 101 RTEYRLIVENLSSRCSWQD-LKDYMRQAGEVTY---ADAHKGRKNEGVIEFVSYSDMKRA 156 Query: 239 LA-FNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPES 297 L +G R +++ KP ++ ++ R R S S + S Sbjct: 157 LEKLDGTEVNGRKIRLVED-----KPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSS 211 Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSR--------RKRSQSKHRSRSHN--RSRSRQKD 347 S+ + RSRS +RS+S+S S+S SR R S+ K RSRSH+ +SRS+ KD Sbjct: 212 KSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271 Query: 348 RRRSKSPH-------KKRSKSRERRKSRSRSHSRDKRKDTREKI-----KEKERVKEKDR 395 + K + K RS SR + KS+SRS S+++R + ++ + +E+ + R Sbjct: 272 QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR 331 Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER---EREKEHEKDRDKE---- 448 + R + R + + R K+KD+ K R++ RE+ + + R R ER ++ RD + Sbjct: 332 SRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSS 391 Query: 449 -KEKEQDKEKEREKDRSKEIDEKRKKDK-------------------KSRTPPRSYNASR 488 K+K++D ++ + + S+ + ++R+ K ++R+ RS + S+ Sbjct: 392 KKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSK 451 Query: 489 -------RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524 RSRS S + R RS+S SRS S + R S S S Sbjct: 452 PNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494 Score = 73.2 bits (178), Expect = 7e-13 Identities = 70/312 (22%), Positives = 109/312 (34%), Gaps = 79/312 (25%) Query: 349 RRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKE 408 R+ + K R R SRSRSHSR + + R + R + + Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSR---------------SRSRHSRKSRSRSGSSK 212 Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468 K++ R + + R K + + + R R K+ EK R KEK + + K RSK D Sbjct: 213 SSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKK-EKSRSPSKEKSRSRSHSAGKSRSKSKD 271 Query: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS---- 524 + +K + + + SRSP K+ + SRS Sbjct: 272 QAEEKIQNNDNV---------------------GKPKSRSPSRHKSKSKSRSRSQERRVE 310 Query: 525 ---------------------------------PRSRNKKDKKREKERDHISERRERERS 551 RSR+K KR+ + E R R RS Sbjct: 311 EEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRS 370 Query: 552 TSMRKSSNDRDGKEKLEKNSTSLKEKE-----HNKEPDSSVSKEVDDKDAPRTEENKIQH 606 S + S R K + S+ K+KE ++ P SVSKE + + ++ Sbjct: 371 RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGE 430 Query: 607 NGNCQLNEENLS 618 + N N+E S Sbjct: 431 SENAGTNQETRS 442 >gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] Length = 202 Score = 140 bits (353), Expect = 3e-33 Identities = 71/206 (34%), Positives = 127/206 (61%), Gaps = 21/206 (10%) Query: 340 RSRSRQKDRRRSKSPHKKRSKSRER-----RKSRSRSHSRDKRKDTR-EKIKEKERVKEK 393 R R R+++ R K ++R + RER R++R R R + +D + ++ KE+ER KE+ Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62 Query: 394 DREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQ 453 DR+++RERE ERE E++R + + R+++R+ DRE+DK++DRER+RE + ++R+++ +E+ Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122 Query: 454 DKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSK 513 DK+ ERE+DR +E +R++++ +R R RE R R R + R R Sbjct: 123 DKQTERERDRERERQRQRERER------------QRQRERKRETDRERQRWAEREERKK- 169 Query: 514 TIKRKSSRSPSPRSRNKKDKKREKER 539 +RK R + + K++K+RE ++ Sbjct: 170 --ERKKERKKERKEKKKEEKRREDKK 193 Score = 137 bits (344), Expect = 4e-32 Identities = 63/197 (31%), Positives = 121/197 (61%), Gaps = 8/197 (4%) Query: 356 KKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415 ++R + RE + + RD++++ + + + R +++DR +ER+R+ +REKE+ER K + Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62 Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK--RKK 473 DR ++RE++ E++ E+ RER+R++E ++ D+E++K++D+E++RE DR++E + K R++ Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122 Query: 474 DKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDK 533 DK++ R R R+R R R R R T + +R + R + R K+ K Sbjct: 123 DKQTE------RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERK 176 Query: 534 KREKERDHISERRERER 550 K KE+ +RRE ++ Sbjct: 177 KERKEKKKEEKRREDKK 193 Score = 133 bits (335), Expect = 4e-31 Identities = 61/195 (31%), Positives = 123/195 (63%), Gaps = 12/195 (6%) Query: 302 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361 ER+ R R R K + R + +Q++ +R R R R++DR+ + ++R K Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61 Query: 362 RERRKSRSRSHSRD-----KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416 R+R++ R R R+ +R+ RE+ ++ +R ++KDR++ER+RE +R +E+ R ++ Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121 Query: 417 RDK----EREKDREKDKEKDREREREKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDE 469 RDK ER+++RE+ ++++RER+R++E +++ D+E+++ ++++KER+K+R KE E Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181 Query: 470 KRKKDKKSRTPPRSY 484 K+K++K+ R + Sbjct: 182 KKKEEKRREDKKRKW 196 Score = 133 bits (334), Expect = 6e-31 Identities = 64/212 (30%), Positives = 128/212 (60%), Gaps = 20/212 (9%) Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384 +R+R + R + R R RQ++R +++ + R + R+R + R R R+K ++ R+K Sbjct: 4 QRERKRETDRGKETERERDRQRERE-NQTERENRHRQRDRHRERDRQTDREKERE-RQKE 61 Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKD 444 ++++R +E++ E+E ER++ER++++ER + DR++++++DRE+ +E DR RER ++ ++ Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121 Query: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504 RDK+ E+E+D+E+ER++ R +E +R+ R R + RER+R R Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRE----------------RKRETDRERQRWAERE 165 Query: 505 SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536 + R K ++K + + ++DKKR+ Sbjct: 166 ERKKER--KKERKKERKEKKKEEKRREDKKRK 195 Score = 128 bits (321), Expect = 2e-29 Identities = 68/206 (33%), Positives = 123/206 (59%), Gaps = 17/206 (8%) Query: 279 MKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH 338 M+R RE + E + GK ER+ R R R H +R R + + R Sbjct: 1 MERQRERKR------ETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDRQTDR 52 Query: 339 NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKERVKEKDREK 397 + R RQK+R R + ++ + ER++ R R R ++ D R+K +++ER +E DR + Sbjct: 53 EKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNR 112 Query: 398 EREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR-----DKEKEKE 452 ER R+ RE++K+ + +DR++ER++ RE+++++ RER+RE + E+ R +++KE++ Sbjct: 113 ERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERK 172 Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSR 478 ++++KER K++ KE EKR++DKK + Sbjct: 173 KERKKER-KEKKKE--EKRREDKKRK 195 Score = 122 bits (307), Expect = 8e-28 Identities = 65/203 (32%), Positives = 123/203 (60%), Gaps = 25/203 (12%) Query: 385 KEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREKEHEK 443 +++ER +E DR KE ERE++R++E+E + + ++R ++R++ RE+D++ DRE+ERE++ E+ Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62 Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503 DR +++E+E ++E ER+++R ++ + KR+ D++ R + RER+R R Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRE------------RDKDRDRERKRETDR 110 Query: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER---RERERSTSM-RKSSN 559 + R+ RK R ++ ++D++RE++R ER RER+R T R+ Sbjct: 111 NRERN--------RKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWA 162 Query: 560 DRDGKEKLEKNSTSLKEKEHNKE 582 +R+ ++K K + KE KE Sbjct: 163 EREERKKERKKERKKERKEKKKE 185 Score = 120 bits (302), Expect = 3e-27 Identities = 60/198 (30%), Positives = 118/198 (59%), Gaps = 8/198 (4%) Query: 381 REKIKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKDREKDKEKDREREREK 439 RE+ +E +R KE +RE++R+RE+E + E+E R + +DR +ER++ +++KE++R++ER++ Sbjct: 5 RERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDR 64 Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499 + +++R+ E+E E+ +E++R+++R ++ D +R KD+ + R+R RER + Sbjct: 65 QRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDK 124 Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559 + R R + +R+ R + K++ RE++R E R++ER +K Sbjct: 125 QTERERDRERERQRQRERERQR----QRERKRETDRERQRWAEREERKKERKKERKK--- 177 Query: 560 DRDGKEKLEKNSTSLKEK 577 +R K+K EK K K Sbjct: 178 ERKEKKKEEKRREDKKRK 195 Score = 115 bits (288), Expect = 1e-25 Identities = 51/191 (26%), Positives = 116/191 (60%), Gaps = 2/191 (1%) Query: 376 KRKDTREKIKEKERVKEKDREKERERE-KEREKEKERGKNKDRDKEREKDREKDKEKDRE 434 KR+ R K E+ER ++++RE + ERE + R++++ R +++ D+E+E++R+K++++ R+ Sbjct: 8 KRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQ 67 Query: 435 REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS 494 RERE E E +R +E++++++++++ +++R K+ D +RK++ R + + Sbjct: 68 RERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTE 127 Query: 495 RERRRRRSRSSSRSPRTSKTIKRK-SSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553 RER R R R R + +RK + R ++++K+E++++ ER+E+++ Sbjct: 128 RERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEK 187 Query: 554 MRKSSNDRDGK 564 R+ + G+ Sbjct: 188 RREDKKRKWGE 198 Score = 100 bits (250), Expect = 3e-21 Identities = 58/193 (30%), Positives = 110/193 (56%), Gaps = 16/193 (8%) Query: 415 KDRDKEREKDREKDKEKDREREREKEHEKDRD-KEKEKEQDKEKEREKDRSKEIDEKRKK 473 + R+++RE DR K+ E++R+R+RE+E++ +R+ + +++++ +E++R+ DR KE + ++++ Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKER 62 Query: 474 DKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK-- 531 D++ + + + R R R+R R+R R + KR++ R+ R RN+K Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRN---RERNRKGG 119 Query: 532 ---DKKREKERDHISER---RERERSTSM-RKSSNDRDGK---EKLEKNSTSLKEKEHNK 581 DK+ E+ERD ER RERER RK DR+ + E+ E+ KE++ + Sbjct: 120 RERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKER 179 Query: 582 EPDSSVSKEVDDK 594 + K +DK Sbjct: 180 KEKKKEEKRREDK 192 Score = 76.6 bits (187), Expect = 6e-14 Identities = 44/146 (30%), Positives = 76/146 (52%), Gaps = 4/146 (2%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331 +E E ++ R+ Q E E+ + ER+ R R R R K R RKR Sbjct: 52 REKERERQKERDRQRQRERETERETERQRERQ--RQRERKRQTDRERDKDRDRERKRETD 109 Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391 ++R R+ R R K R + ++R + RER + R R R+ ++ + + +ER K Sbjct: 110 RNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169 Query: 392 EKDREKEREREKEREKEKERGKNKDR 417 E+ +E+++ER KE++KE++R ++K R Sbjct: 170 ERKKERKKER-KEKKKEEKRREDKKR 194 Score = 75.9 bits (185), Expect = 1e-13 Identities = 50/189 (26%), Positives = 93/189 (49%), Gaps = 20/189 (10%) Query: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493 ER+RE++ E DR KE E+E ++++RE++ E + + ++ + R R + R Sbjct: 2 ERQRERKRETDRGKETERE--RDRQRERENQTERENRHRQRDRHRERDR-----QTDREK 54 Query: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553 RER++ R R R T + +R+ R + + D++R+K+RD RER+R T Sbjct: 55 ERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRD-----RERKRETD 109 Query: 554 MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLN 613 + N + G+E+ ++ E+E ++E + +E ++ R E K + + Q Sbjct: 110 RNRERNRKGGRERDKQT-----ERERDRERERQRQRE---RERQRQRERKRETDRERQRW 161 Query: 614 EENLSTKTE 622 E K E Sbjct: 162 AEREERKKE 170 Score = 74.7 bits (182), Expect = 2e-13 Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 10/150 (6%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331 KE E +R R+ Q E E+ + ER+ R R R + + R R+R + Sbjct: 54 KERERQKERDRQRQR------ERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE 107 Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391 R+R NR R++D++ + ++R + R+R + R R R KR+ RE+ + ER + Sbjct: 108 TDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRER-KRETDRERQRWAER-E 165 Query: 392 EKDREKEREREKER-EKEKERGKNKDRDKE 420 E+ +E+++ER+KER EK+KE + +D+ ++ Sbjct: 166 ERKKERKKERKKERKEKKKEEKRREDKKRK 195 >gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial [Homo sapiens] Length = 213 Score = 139 bits (349), Expect = 1e-32 Identities = 73/221 (33%), Positives = 131/221 (59%), Gaps = 12/221 (5%) Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD 379 SK+ R ++++ R R R R+ DR R ++ K SK+ +R R R R++ Sbjct: 3 SKTEGRHTHTETETMDRQ--RERRRETDRERDRA---KESKTEDRHSERDRQRDRERN-- 55 Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREK 439 RE+ +++ER K+ DRE ER+RE+ER+++++R ++RDKERE DR + +++R++++E+ Sbjct: 56 -RERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKER 114 Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499 E E+ RD+E+EK+++ +ER+ DR + + +R+ +++ T R R R RER+R Sbjct: 115 EMERVRDREREKQKEMGRERQTDRETDRERERQAERERET-GRERKTEDRHRERERERKR 173 Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540 R R R T + + + R K+D++RE ER+ Sbjct: 174 ERERKRETKERERHTDMERERQRETDR---KRDRQRESERE 211 Score = 130 bits (328), Expect = 3e-30 Identities = 74/223 (33%), Positives = 125/223 (56%), Gaps = 28/223 (12%) Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 421 R+R + R RD+ K+++ + + ER +++DRE+ RER+++RE+EK+ + +R +ER Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRER 78 Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481 E+DR D++++ ERER+KE E DR E ++E+ K+KERE +R + D +R+K K+ Sbjct: 79 ERDR--DRQRETERERDKERETDRHTETDRERQKQKEREMERVR--DREREKQKE----- 129 Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541 R R + RE R R R + R T R R +D+ RE+ER+ Sbjct: 130 -----MGRERQTDRETDRERERQAERERETG-------------RERKTEDRHRERERER 171 Query: 542 ISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584 E RER+R T R+ D + + + E + +++E +E D Sbjct: 172 KRE-RERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213 Score = 128 bits (322), Expect = 1e-29 Identities = 62/199 (31%), Positives = 119/199 (59%), Gaps = 13/199 (6%) Query: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 372 R + R + + R K S+++ R +R R R+++R R + +++ RE + R R Sbjct: 21 RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80 Query: 373 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK----DREKD 428 RD++++T +E+++ +E DR E +RE++++KE+E + +DR++E++K +R+ D Sbjct: 81 DRDRQRETE---RERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTD 137 Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 488 +E DRERER+ E E++ +E+ K +D+ +ERE++R +E + KR+ ++ R + Sbjct: 138 RETDRERERQAERERETGRER-KTEDRHRERERERKRERERKRETKERER-----HTDME 191 Query: 489 RSRSSSRERRRRRSRSSSR 507 R R +R+R R R S R Sbjct: 192 RERQRETDRKRDRQRESER 210 Score = 125 bits (315), Expect = 9e-29 Identities = 67/192 (34%), Positives = 113/192 (58%), Gaps = 15/192 (7%) Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358 + ER+ R R+K + HS R R + + R+R +R R R+K R ++R Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRER 78 Query: 359 SKSRERRKSRSRSHSRDKRKDT-REKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417 + R+R++ R RDK ++T R ++ER K+K+RE ER R++EREK+KE G+ + Sbjct: 79 ERDRDRQRETERE--RDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQT 136 Query: 418 DKEREKDREKDKEKDREREREK-------EHEKDRDKEKE-KEQDKEKER----EKDRSK 465 D+E +++RE+ E++RE RE+ E E++R +E+E K + KE+ER E++R + Sbjct: 137 DRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDMERERQR 196 Query: 466 EIDEKRKKDKKS 477 E D KR + ++S Sbjct: 197 ETDRKRDRQRES 208 Score = 117 bits (294), Expect = 2e-26 Identities = 62/202 (30%), Positives = 112/202 (55%), Gaps = 13/202 (6%) Query: 277 EVMKRVREAQSFISAAIE-PESGKSNERKGGRSRSHTRSKSRSSSKSHSRRK-------R 328 E M R RE + + + K+ +R R R R ++R + R K R Sbjct: 15 ETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGER 74 Query: 329 SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKE 388 + + R R R R++D+ R H + + R+++K R RD+ REK KE Sbjct: 75 QRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE---REKQKEMG 131 Query: 389 RVKEKDREKEREREKEREKEKERGK-NKDRDKEREKDREKDKEKDRERE-REKEHEKDRD 446 R ++ DRE +RERE++ E+E+E G+ K D+ RE++RE+ +E++R+RE +E+E D + Sbjct: 132 RERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDME 191 Query: 447 KEKEKEQDKEKEREKDRSKEID 468 +E+++E D++++R+++ +E D Sbjct: 192 RERQRETDRKRDRQRESERERD 213 Score = 72.0 bits (175), Expect = 2e-12 Identities = 38/147 (25%), Positives = 72/147 (48%), Gaps = 8/147 (5%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQS 331 K+ + +R RE + E E + ER+ R R + + + R R R + Sbjct: 66 KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125 Query: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR-------KSRSRSHSRDKRKDTREKI 384 K + R R+ DR R + ++R RER+ + R R R+++++T+E+ Sbjct: 126 KQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERE 185 Query: 385 KEKERVKEKDREKEREREKEREKEKER 411 + + +E+ RE +R+R+++RE E+ER Sbjct: 186 RHTDMERERQRETDRKRDRQRESERER 212 Score = 57.0 bits (136), Expect = 5e-08 Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 32/142 (22%) Query: 267 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRR 326 T + K+ E M+RVR+ + E + ER+ R R + + R Sbjct: 104 TDRERQKQKEREMERVRDRER------EKQKEMGRERQTDRETDRERERQAERERETGRE 157 Query: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386 ++++ +HR R R R R++ K+ +K RER E Sbjct: 158 RKTEDRHRERERERKRERER---------KRETKERERHTD-----------------ME 191 Query: 387 KERVKEKDREKEREREKEREKE 408 +ER +E DR+++R+RE ERE++ Sbjct: 192 RERQRETDRKRDRQRESERERD 213 >gi|42560244 peptidylprolyl isomerase G [Homo sapiens] Length = 754 Score = 138 bits (348), Expect = 1e-32 Identities = 109/373 (29%), Positives = 178/373 (47%), Gaps = 54/373 (14%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 KE + RV+E + + + NE++ + SK R ++ + + ++K Sbjct: 392 KENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNK 451 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 + R+ ++SRS+ K++ +SK K +++ E+R RSRS RD E +KEKE+ + Sbjct: 452 VKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM-RSRSKGRD-----HENVKEKEKQSD 505 Query: 393 -KDREKEREREKEREKEKERGKNK-DRDKEREKDRE-----------KDKEKDREREREK 439 K +++ER R KE+ K+ E N+ D K +EKDR K K R RE+ Sbjct: 506 SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRER 565 Query: 440 EHEKDRD---KEKEKEQDKEKEREKDRSKEIDEKRK---KDKKSRTPPRSYNASRRSRSS 493 +DR + + ++D+ + +E R +E + +R+ + ++ RTPP RSRS Sbjct: 566 SRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPP------GRSRSK 619 Query: 494 SRERRRRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKR--EKERDHISERRERE 549 R RRRR SRSS R S +K R S R N + +KR K RDH S RE Sbjct: 620 DRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSRE 679 Query: 550 RS--------TSMRKSSNDRDGKEKLEKNSTSLK-----EKEHNKEPDS------SVSKE 590 + + +++SS D + K + KN K EKE+ K +K+ Sbjct: 680 KKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739 Query: 591 VDDKDAPRTEENK 603 D + +P T+E+K Sbjct: 740 FDHESSPGTDEDK 752 Score = 137 bits (344), Expect = 4e-32 Identities = 105/383 (27%), Positives = 196/383 (51%), Gaps = 36/383 (9%) Query: 267 TPQAAAKELEEVMK-RVREAQSFISA-AIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 324 TP +E++ + RV + +I E K N+R R + + R+ S+S + Sbjct: 358 TPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPN 417 Query: 325 RRKRSQSKHRSRSHNRSRSRQKD-RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----D 379 R+ + K + ++S S+++D RR S+ K ++K ++R KS+SRS S++K K D Sbjct: 418 RKNEKEKKVKD---HKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERD 474 Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKE-RGKNKDRDKEREK-----------DREK 427 ++ E++R++ + + ++ E KE+EK+ + +GK+++R + +EK D K Sbjct: 475 SKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSK 534 Query: 428 DKEKDRE-REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP----R 482 KEKDR + R +E + + K + +E+ R +DRS+ + + +SR+ R Sbjct: 535 SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594 Query: 483 SYNASRRSRSSSRERR----RRRSRSSSRSPRTSKTIKRKSSRSPS-PRSRNKKDKKREK 537 RR RS SRERR R RS+ R R S++ +R+ S+S + + RN++ K + Sbjct: 595 EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHR 654 Query: 538 ERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS-LKEKEHNKEPDSSVSKEVDD--- 593 + + SE+R +S S+N R+ K +++ S +K+ + E SS+ K +D Sbjct: 655 KENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKI 714 Query: 594 KDAPRTEENKIQHNGNCQLNEEN 616 + + E K + N ++E+N Sbjct: 715 RSSVEKENQKSKGQENDHVHEKN 737 Score = 126 bits (317), Expect = 5e-29 Identities = 99/356 (27%), Positives = 168/356 (47%), Gaps = 59/356 (16%) Query: 298 GKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSR-------------------SH 338 G+ R SRS +R + R S R+ Q R R + Sbjct: 335 GRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKEN 394 Query: 339 NRSRSRQKDRRR------SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 RS R K+R+ S+SP++K K ++ + +S S RD R+++ + K K +VK+ Sbjct: 395 QRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKK 454 Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-- 450 R + K R K KE+ K+K+RD + ++ EK + R R + ++HE ++KEK+ Sbjct: 455 ------RAKSKSRSKSKEKSKSKERDSKHNRNEEK---RMRSRSKGRDHENVKEKEKQSD 505 Query: 451 -KEQDKEKEREKDRSKEIDEK---------RKKDKKSRTPPR---------SYNASRRSR 491 K +D+E+ R K++SK+++ K ++KD+++++ R SYN+ R R Sbjct: 506 SKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRER 565 Query: 492 SSSRERRRR-RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE---KERDHISERRE 547 S SR+R RR RSR+ R SK R + R R++ ++R + R RR Sbjct: 566 SRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRR 625 Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 R+ +S R+ S R+ + + S S KE+++ SK D + + E K Sbjct: 626 RDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKK 681 Score = 97.4 bits (241), Expect = 3e-20 Identities = 97/413 (23%), Positives = 172/413 (41%), Gaps = 79/413 (19%) Query: 265 EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS 324 E+ P++ K+ E+ + + S S+ + S + S S T KS+ K H Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKH- 234 Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-------SHSRDKR 377 + SR H + + ++K ++S S + + +S R +R Sbjct: 235 -------RKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLM 287 Query: 378 KDTREKIKEKERVKEKDREKERERE------------------KEREKEKERGKNKDRDK 419 + + K EKER K+RE+ERERE + K K RG + R Sbjct: 288 RKSPPKADEKER---KNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTP 344 Query: 420 EREKDREKDKEKD------REREREK--------------EHEKDRDKEKEKEQDKEKER 459 R + R++ + + +E +R + + E + KE ++ + KER Sbjct: 345 SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKER 404 Query: 460 ---------EKDRSKEIDEKRKKDKKSRTPPRSY--NASRRSRSSSRERRRRRSRSSSRS 508 E K EK+ KD KS + R N+ + + ++ ++R +S+S S+S Sbjct: 405 KITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKS 464 Query: 509 PRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 568 SK+ +R S + R+ K+ + R K RDH + + + ++S S K KEK + Sbjct: 465 KEKSKSKERDSKHN---RNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSK 521 Query: 569 KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE---NKIQHNGNCQLNEENLS 618 + + E +H+K SKE D + R+ E K +H+ N + E + S Sbjct: 522 QLESKSNEHDHSK------SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRS 568 Score = 95.5 bits (236), Expect = 1e-19 Identities = 75/307 (24%), Positives = 131/307 (42%), Gaps = 46/307 (14%) Query: 266 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 325 M ++ ++ E V ++ +++ S S + +++ +S H SKS+ + Sbjct: 485 MRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQS 544 Query: 326 RKR----SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR 381 R R ++ KH S R RSR +DR R+ RSR+H RD R Sbjct: 545 RSRECDITKGKHSYNSRTRERSRSRDR---------------SRRVRSRTHDRD-----R 584 Query: 382 EKIKEKERVKEKD-REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440 + KE R +E++ R + R R +ER R ++KDR + R R E+E Sbjct: 585 SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSS----------ERE 634 Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR- 499 + R+K+K + Q+ + K+ S+ EKR K R +N+S SR +R + Sbjct: 635 ESQSRNKDKYRNQESKSSHRKENSE--SEKRMYSKS-----RDHNSSNNSREKKADRDQS 687 Query: 500 ---RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556 + +SS + S +K K + K + +E DH+ E+ ++ S Sbjct: 688 PFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPG 747 Query: 557 SSNDRDG 563 + D+ G Sbjct: 748 TDEDKSG 754 Score = 87.4 bits (215), Expect = 4e-17 Identities = 91/376 (24%), Positives = 159/376 (42%), Gaps = 54/376 (14%) Query: 270 AAAKELEEVMKRVREAQSFI-SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328 AA+K EV R+ I + ++ E K ++ S S + S S S S+S S Sbjct: 161 AASKPFAEV--RILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSD 218 Query: 329 SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKE 388 S+S +S R + +K+ R+ K KKR KS++ S S + + + + + + +E Sbjct: 219 SESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIP 278 Query: 389 RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKE 448 + E + K EKE+ +++ERE++RE + + ++ R Sbjct: 279 PIPENRFLMRKSPPKADEKER-------KNRERERERECNPPNSQPASYQRRLLVTRSGR 331 Query: 449 KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP---RSYNASRRSRSSSRERRRRRSRS- 504 K K + + R RS+ D R+ S TPP + ++R R SS ER + +S Sbjct: 332 KIKGRGPRRYRTPSRSRSRDRFRR----SETPPHWRQEMQRAQRMRVSSGERWIKGDKSE 387 Query: 505 ------SSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER---------- 548 + RSP K K R+ S S N+K++K +K +DH S +ER Sbjct: 388 LNEIKENQRSPVRVKERKITDHRNVS-ESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDD 446 Query: 549 -------------------ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589 E+S S + S +EK ++ + ++ E+ KE + Sbjct: 447 KYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDS 506 Query: 590 EVDDKDAPRTEENKIQ 605 + D++ R++E Q Sbjct: 507 KGKDQERSRSKEKSKQ 522 Score = 87.4 bits (215), Expect = 4e-17 Identities = 74/253 (29%), Positives = 121/253 (47%), Gaps = 36/253 (14%) Query: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313 +H N VK E + K+ E + + Q S + E + KS E K R++S +R Sbjct: 493 DHEN---VKEKEKQSDSKGKDQERSRSKEKSKQ-LESKSNEHDHSKSKE-KDRRAQSRSR 547 Query: 314 SKSRSSSK-SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSP-----------HKKRSKS 361 + K S++ R R +S+ R RS R RSR DR RS+S + RS+S Sbjct: 548 ECDITKGKHSYNSRTRERSRSRDRSR-RVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRS 606 Query: 362 RERRKSRSRSHSRD---KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418 RERR RS S+D +R+D+R +E+ + + KD+ + +E + KE + + Sbjct: 607 RERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYS 666 Query: 419 KERE-----KDREKDKEKDRE-----REREKEHEKDRDKEKEKEQDK-----EKEREKDR 463 K R+ REK ++D+ ++ +++E K KE +K EKE +K + Sbjct: 667 KSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSK 726 Query: 464 SKEIDEKRKKDKK 476 +E D +K+KK Sbjct: 727 GQENDHVHEKNKK 739 Score = 67.8 bits (164), Expect = 3e-11 Identities = 56/232 (24%), Positives = 99/232 (42%), Gaps = 33/232 (14%) Query: 252 KINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH 311 K N +++ K + Q+ ++E + + S+ S E + R+ RSR+H Sbjct: 526 KSNEHDHSKSKEKDRRAQSRSRECDITKGK----HSYNSRTRERSRSRDRSRRV-RSRTH 580 Query: 312 TRSKSRSSS-------------KSHSR-------RKRSQSKHRSRSHNRSRSRQKDRRRS 351 R +SRS +S SR R RS+ + R R +RS R++ + R+ Sbjct: 581 DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRN 640 Query: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE-----KEREREKERE 406 K ++ + RK S S R K R K+ DR+ K ++ ++ E Sbjct: 641 KDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNE 700 Query: 407 KEKERGKNKDRDKER---EKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455 + KNK+ +K R EK+ +K K ++ + EK + D + ++DK Sbjct: 701 LKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752 >gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] Length = 285 Score = 132 bits (331), Expect = 1e-30 Identities = 72/187 (38%), Positives = 116/187 (62%), Gaps = 6/187 (3%) Query: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352 + P + ER+ R R R+K R K K + + R R R R R +DR+R + Sbjct: 52 VAPAIIRERERQRERERQRKRAKERHREKDREIEK-DRDRQRKRDRERQRWRDRDRKRER 110 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEK-ER 411 + R ER++ R R R + KD RE+ +++E +KDRE E E++++RE+E E Sbjct: 111 WGDRDRETETERQEERERQRDRKREKD-RERQRQREIGIDKDREIETEKDRDREREMGET 169 Query: 412 GKNKDRDKEREKDREKDKEKDREREREKE-HEKDRDKEKEKEQDKEKERE--KDRSKEID 468 + +DR++ER+K RE +++DRER+REKE E+DRD++KE+E+D+ +ERE +DR KE D Sbjct: 170 ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229 Query: 469 EKRKKDK 475 +R+++K Sbjct: 230 RERQREK 236 Score = 130 bits (327), Expect = 4e-30 Identities = 68/192 (35%), Positives = 123/192 (64%), Gaps = 21/192 (10%) Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385 R+R + + R R + R R+KDR K ++R + RER++ R R R++ D R++ Sbjct: 60 RERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGD-RDRET 118 Query: 386 EKERVKEKDREKEREREKEREKEKER--GKNKDRDKEREKDREKDKE-------KDRERE 436 E ER +E++R+++R+REK+RE++++R G +KDR+ E EKDR++++E +DRERE Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178 Query: 437 REKEHEKDRDKEKEKEQDKE-KEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495 R+K+ E RD+++E++++KE +ER++DR KE ++ R ++++ + R R R Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERE----------TGRDRDKER 228 Query: 496 ERRRRRSRSSSR 507 +R R+R + R Sbjct: 229 DRERQREKDRDR 240 Score = 127 bits (319), Expect = 3e-29 Identities = 63/187 (33%), Positives = 117/187 (62%), Gaps = 12/187 (6%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSK 352 E E + ER+ R++ R K R K R RKR + + R R +R R R DR R Sbjct: 59 ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKE-------REREKE 404 ++ + R+R + R + R ++++ +K +E E K++DRE+E R+RE+E Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178 Query: 405 REKEKERGKNKDRDKEREKD---REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK 461 R+K++E +++DR+++REK+ R++D++K+RE++R +E E RD++KE+++++++E+++ Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDR 238 Query: 462 DRSKEID 468 DR K ID Sbjct: 239 DRQKAID 245 Score = 119 bits (299), Expect = 6e-27 Identities = 62/204 (30%), Positives = 116/204 (56%), Gaps = 9/204 (4%) Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403 R+++R+R + +KR+K R R K R RD++ R++ +E++R +++DR++ER ++ Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQ---RKRDRERQRWRDRDRKRERWGDR 114 Query: 404 EREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR 463 +RE E ER +ERE+ R++ +EKDRER+R++E D+D+E E E+D+++ERE Sbjct: 115 DRETETER------QEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGE 168 Query: 464 SKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSP 523 ++ ++ ++ +K R R + R+ RER R R + + + R + Sbjct: 169 TERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKER 228 Query: 524 SPRSRNKKDKKREKERDHISERRE 547 + +KD+ R+K D + R E Sbjct: 229 DRERQREKDRDRQKAIDCVPGRWE 252 Score = 118 bits (295), Expect = 2e-26 Identities = 65/212 (30%), Positives = 126/212 (59%), Gaps = 29/212 (13%) Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER 421 RER + R R R++ + KER +EKDRE E++R+++R++++ER + +DRD++R Sbjct: 58 RERERQRERE---------RQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKR 108 Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481 E+ ++D+E + ER+ E+E ++DR +EK++E+ +++E D+ +EI+ ++ +D++ Sbjct: 109 ERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRE----- 163 Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541 R + R R RER+++R R R+ R R R+ +D+++E+E+D Sbjct: 164 REMGETERYRDRERERQKQRETRRDRD--------RERQREKEDRERD-RDRQKEREKDR 214 Query: 542 ISER-----RERERSTSMRKSSNDRDGKEKLE 568 ER R++ER R+ DRD ++ ++ Sbjct: 215 YRERETGRDRDKERDRE-RQREKDRDRQKAID 245 Score = 114 bits (284), Expect = 4e-25 Identities = 60/206 (29%), Positives = 116/206 (56%), Gaps = 18/206 (8%) Query: 387 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRD 446 +ER ++++RE++R+R KER +EK+R KDRD++R++DRE+ + +DR+R+RE+ DRD Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWG--DRD 115 Query: 447 KEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS 506 +E E E+ +E+ER++DR +E D +R++ ++ R + ++R R R + Sbjct: 116 RETETERQEERERQRDRKREKDRERQRQREIGID------KDREIETEKDRDREREMGET 169 Query: 507 RSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 566 R + ++K + R R ++ +K ++ERD ++ + R++ DRD + Sbjct: 170 ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKE-- 227 Query: 567 LEKNSTSLKEKEHNKEPDSSVSKEVD 592 +++E +E D K +D Sbjct: 228 --------RDRERQREKDRDRQKAID 245 Score = 107 bits (268), Expect = 3e-23 Identities = 57/191 (29%), Positives = 102/191 (53%), Gaps = 4/191 (2%) Query: 261 VKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSS 320 V P + + +E E KR +E IE + + +R R R R + R Sbjct: 52 VAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERW 111 Query: 321 KSHSRR---KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377 R +R + + R R R + R++ R+R K R E+ + R R +R Sbjct: 112 GDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETER 171 Query: 378 KDTREKIKEKERVKEKDREKEREREKE-REKEKERGKNKDRDKEREKDREKDKEKDRERE 436 RE+ ++K+R +DR++ER+REKE RE++++R K +++D+ RE++ +D++K+R+RE Sbjct: 172 YRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRE 231 Query: 437 REKEHEKDRDK 447 R++E ++DR K Sbjct: 232 RQREKDRDRQK 242 Score = 90.9 bits (224), Expect = 3e-18 Identities = 52/191 (27%), Positives = 106/191 (55%), Gaps = 13/191 (6%) Query: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472 + ++R +ERE+ R++ KE R RE+++E EKDRD+++++++++++ R++DR +E Sbjct: 58 RERERQRERERQRKRAKE--RHREKDREIEKDRDRQRKRDRERQRWRDRDRKRE--RWGD 113 Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSR----SSSRSPRTSKTIKRKSSRSPSPRSR 528 +D+++ T + +R R ++R R+R R R T K R+ + R R Sbjct: 114 RDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYR 173 Query: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588 + ++++R+K+R+ RR+R+R K +RD + E+ +E+E ++ D Sbjct: 174 D-RERERQKQRE---TRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229 Query: 589 KEVD-DKDAPR 598 +E +KD R Sbjct: 230 RERQREKDRDR 240 Score = 58.5 bits (140), Expect = 2e-08 Identities = 46/188 (24%), Positives = 84/188 (44%), Gaps = 53/188 (28%) Query: 433 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492 RERER++E E+ R + KE+ ++K++E EKDR D +RK+D R R Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDR----DRQRKRD--------------RERQ 99 Query: 493 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-----RE 547 R+R R+R R R T + +++ E+ER +R R+ Sbjct: 100 RWRDRDRKRERWGDRDRET------------------ETERQEERERQRDRKREKDRERQ 141 Query: 548 RERSTSMRK-----SSNDRDGKEKL-------EKNSTSLKEKEHNKEPDSSVSKEVDDKD 595 R+R + K + DRD + ++ ++ K++E ++ D +E +D++ Sbjct: 142 RQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRE 201 Query: 596 APRTEENK 603 R + + Sbjct: 202 RDRDRQKE 209 Score = 48.1 bits (113), Expect = 2e-05 Identities = 30/131 (22%), Positives = 55/131 (41%), Gaps = 2/131 (1%) Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536 SR P R R R+R+R + R + K R+ R + +D+KRE Sbjct: 50 SRVAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRE 109 Query: 537 K--ERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594 + +RD +E +E R ++D + + ++ K++E E D +E+ + Sbjct: 110 RWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGET 169 Query: 595 DAPRTEENKIQ 605 + R E + Q Sbjct: 170 ERYRDRERERQ 180 Score = 34.3 bits (77), Expect = 0.35 Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 21/133 (15%) Query: 478 RTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREK 537 +T P S+ + RS+ R+ R R + I R+ R + K+ K+R + Sbjct: 25 QTRPVSWRLAMRSQIEDRDVL------ILRGSRVAPAIIRERERQRERERQRKRAKERHR 78 Query: 538 ERDHISE-------RRERERS-----TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585 E+D E +R+RER R+ DRD + + E+ ++++ +E D Sbjct: 79 EKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDR 138 Query: 586 SVSKEVD---DKD 595 ++ + DKD Sbjct: 139 ERQRQREIGIDKD 151 >gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sapiens] Length = 805 Score = 129 bits (324), Expect = 8e-30 Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%) Query: 257 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315 N I K A+E + +V+ + + ++ +EP+ + K GRSRS S Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513 Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 369 S SS S+SR + S S S++ S + RS SP +K+ SR R R+SRS Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573 Query: 370 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 413 RS+SR D+R+ R I +E+ R + RE+ R R + R++ R + Sbjct: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633 Query: 414 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 458 ++ RD+ + K + + KE++R++ER + +KDR DKE+E+EQDK KE Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693 Query: 459 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 511 ++K K+ D ++K + RT RS + S + R SR+ ++ + S+ Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753 Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556 S + R SS SP S+ KK KK + R E+ +R + RK Sbjct: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797 Score = 73.9 bits (180), Expect = 4e-13 Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%) Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 417 S + R R S ++ R +I++K+ KEK+++ +++ E EK++ K+ Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455 Query: 418 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470 ++ K++ ++ + D E+++ + + K++ KEKE++ Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515 Query: 471 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 524 SRT S S S SSS R SRSSS S S TIK + SRS S Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575 Query: 525 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 559 +RN +++R + R ER R R+R T+ S Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635 Query: 560 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601 RD ++ K+ KE+E KE S+ K+ KD R E Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687 Score = 69.3 bits (168), Expect = 1e-11 Identities = 68/332 (20%), Positives = 126/332 (37%), Gaps = 43/332 (12%) Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRERRKSRSRSHSRDK 376 S+ + S+S R R RQK R+ K K E K ++ +++ Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455 Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436 + ++ ++ ++ + + EK+R + + + + +EK+++ Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515 Query: 437 REKEHE--------------------KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475 R + ++K + RS I +R + + Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575 Query: 476 -------KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528 +S RRS +S ER RRR+RS SR R S++ R + + RSR Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635 Query: 529 NKKDKKREKERDHIS--------ERRERERSTSMRKSSNDRDGKEK---LEKNSTSLKEK 577 ++ +K + +R ++S E +E+ER R S D+D K+K E+ KEK Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE-RSRSIDKDRKKKDKEREREQDKRKEK 694 Query: 578 EHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 609 + +E D S + D R E +G+ Sbjct: 695 QKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726 Score = 37.7 bits (86), Expect = 0.032 Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%) Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405 ++RR S + R +S + D K +E +++ +REK+++ EKER Sbjct: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255 Query: 406 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 456 E++R + ++K+ +D E + K E E + E+ + K Sbjct: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314 Query: 457 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 485 +E+ E+ E+ K KD K ++ P + Sbjct: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374 Query: 486 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 531 S S S R R S S + ++ + + R +K Sbjct: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434 Query: 532 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 587 DK+ E+E+ +ER +E + + K N E E + + EK+ +SV Sbjct: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493 Query: 588 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 621 KE +K+ + +G+ N ST + Sbjct: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529 >gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sapiens] Length = 805 Score = 129 bits (324), Expect = 8e-30 Identities = 103/345 (29%), Positives = 166/345 (48%), Gaps = 48/345 (13%) Query: 257 NNAIVKPPEMTPQAAAKELE-EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSK 315 N I K A+E + +V+ + + ++ +EP+ + K GRSRS S Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG--SS 513 Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRS 369 S SS S+SR + S S S++ S + RS SP +K+ SR R R+SRS Sbjct: 514 SSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRS 573 Query: 370 RSHSR--------------DKRKDTREKI-KEKERVKEKDREKEREREKEREKEKER-GK 413 RS+SR D+R+ R I +E+ R + RE+ R R + R++ R + Sbjct: 574 RSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASR 633 Query: 414 NKDRDKER------------EKDREKDKEKDREREREKEHEKDR---DKEKEKEQDKEKE 458 ++ RD+ + K + + KE++R++ER + +KDR DKE+E+EQDK KE Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKE 693 Query: 459 REKDRSKEI------DEKRKKDKKSRTPPRSYNAS-RRSRSSSRERRRRRSRSSSRSPRT 511 ++K K+ D ++K + RT RS + S + R SR+ ++ + S+ Sbjct: 694 KQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSG 753 Query: 512 SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556 S + R SS SP S+ KK KK + R E+ +R + RK Sbjct: 754 SDSSGRSSSESPG-SSKEKKAKKPKHSRSRSVEKSQRSGKKASRK 797 Score = 73.9 bits (180), Expect = 4e-13 Identities = 71/292 (24%), Positives = 117/292 (40%), Gaps = 51/292 (17%) Query: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDREKEREREKEREKEKERGKNKDR 417 S + R R S ++ R +I++K+ KEK+++ +++ E EK++ K+ Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455 Query: 418 DKEREKDRE-------KDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEK 470 ++ K++ ++ + D E+++ + + K++ KEKE++ Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515 Query: 471 RKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS------RSPRTSKTIKRKSSRSPS 524 SRT S S S SSS R SRSSS S S TIK + SRS S Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575 Query: 525 --------------------PRSRNKKDKKREKERDHISER-----RERERSTSMRKSSN 559 +RN +++R + R ER R R+R T+ S Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635 Query: 560 DRDGKE----------KLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601 RD ++ K+ KE+E KE S+ K+ KD R E Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687 Score = 69.3 bits (168), Expect = 1e-11 Identities = 68/332 (20%), Positives = 126/332 (37%), Gaps = 43/332 (12%) Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRERRKSRSRSHSRDK 376 S+ + S+S R R RQK R+ K K E K ++ +++ Sbjct: 396 SEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEM 455 Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436 + ++ ++ ++ + + EK+R + + + + +EK+++ Sbjct: 456 NEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSS 515 Query: 437 REKEHE--------------------KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK- 475 R + ++K + RS I +R + + Sbjct: 516 GSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575 Query: 476 -------KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528 +S RRS +S ER RRR+RS SR R S++ R + + RSR Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSR 635 Query: 529 NKKDKKREKERDHIS--------ERRERERSTSMRKSSNDRDGKEK---LEKNSTSLKEK 577 ++ +K + +R ++S E +E+ER R S D+D K+K E+ KEK Sbjct: 636 SRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKE-RSRSIDKDRKKKDKEREREQDKRKEK 694 Query: 578 EHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 609 + +E D S + D R E +G+ Sbjct: 695 QKREEKDFKFSSQDDRLKRKRESERTFSRSGS 726 Score = 37.7 bits (86), Expect = 0.032 Identities = 64/336 (19%), Positives = 118/336 (35%), Gaps = 62/336 (18%) Query: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405 ++RR S + R +S + D K +E +++ +REK+++ EKER Sbjct: 196 QNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKER 255 Query: 406 EKEKERGKNKDRDKEREKDRE---------KDKEKDREREREKEHEKDRDKEKEKEQDKE 456 E++R + ++K+ +D E + K E E + E+ + K Sbjct: 256 -MEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSP 314 Query: 457 KEREKDRSKEIDEKRK----------------------------KD---KKSRTPPRSYN 485 +E+ E+ E+ K KD K ++ P + Sbjct: 315 VPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLA 374 Query: 486 ASRRSRS-----------SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK--- 531 S S S R R S S + ++ + + R +K Sbjct: 375 QSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQ 434 Query: 532 ---DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV- 587 DK+ E+E+ +ER +E + + K N E E + + EK+ +SV Sbjct: 435 LLHDKQMEEEKQQ-TERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVL 493 Query: 588 --SKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKT 621 KE +K+ + +G+ N ST + Sbjct: 494 EPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSS 529 >gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] Length = 275 Score = 127 bits (318), Expect = 4e-29 Identities = 77/237 (32%), Positives = 130/237 (54%), Gaps = 21/237 (8%) Query: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD 375 SR++ K ++ + H S+ + S +K RR + +KR + RE+ + R R Sbjct: 7 SRAAVKLNTELQMVSCSHISKPCTQRESERKKERRER---EKRKREREKERKRERGKKEK 63 Query: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR-E 434 K++ RE+ KE+ER K K+REK+R+ +E+E+ K + + K R++++ RE+ K+K+R E Sbjct: 64 KKRKKRERGKERER-KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE 122 Query: 435 RERE--KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492 RERE + E+ R K ++K++ KE++REK+R K +++K+ K+ R R N R+ R Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN--RKERK 180 Query: 493 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549 RER+ RR R R K + KKD+K +++ D R RE Sbjct: 181 KERERKERRERKKERKKERRK------------KKERKKDRKTDRQTDSQVFRPLRE 225 Score = 126 bits (317), Expect = 5e-29 Identities = 67/202 (33%), Positives = 118/202 (58%), Gaps = 8/202 (3%) Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER-EREKEHEK 443 +E ER KE+ ++R+RE+E+E+++ERGK ++K++ K RE+ KE++R+R EREK+ ++ Sbjct: 32 RESERKKERREREKRKREREKERKRERGK---KEKKKRKKRERGKERERKRKEREKQRKE 88 Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR-RSRSSSRERRRRRS 502 R+KE+ K + ++K+RE+ + + K+KK++K R R R + ++RR+ R Sbjct: 89 RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148 Query: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562 R R R K KRK R RN+K++K+E+ER ER++ + +K +D Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208 Query: 563 GKEKLEKNS---TSLKEKEHNK 581 K + +S L+E N+ Sbjct: 209 RKTDRQTDSQVFRPLRESAFNR 230 Score = 122 bits (307), Expect = 8e-28 Identities = 67/181 (37%), Positives = 111/181 (61%), Gaps = 11/181 (6%) Query: 296 ESGKSNER----KGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS 351 ES + ER K R R R + R + R+KR + K R R ++K+RR Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92 Query: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE--REKEREKEK 409 + +K+ K + RK R R R K+K+ +E+ +E ++ +E+ R+K R+ R KER++EK Sbjct: 93 ERRKRKKEKKKRERKQRGR-RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151 Query: 410 ERGKNKDRDKEREKD-REKDKE---KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465 ERGK + + K+R+K+ REK +E K+R++ERE++ ++R KE++KE+ K+KER+KDR Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211 Query: 466 E 466 + Sbjct: 212 D 212 Score = 121 bits (303), Expect = 2e-27 Identities = 64/188 (34%), Positives = 120/188 (63%), Gaps = 7/188 (3%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353 +P + + +ERK R R + R + R K+ + K + R + R R++ + R K Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR-KEREKQ 85 Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413 ++R K R +RK + R K++ RE+ K+KER KE++RE ++ RE++R+K +++ + Sbjct: 86 RKERREKERRKRKKEKKKRER-KQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKR 143 Query: 414 NKDRDKEREKD-REKDKEKDREREREKEHEKDR-DKEKEKEQDKEKEREKDRSKEIDEK- 470 K+R +E+E+ RE+ ++K ++ EREK+ E++R +++KE+E+ + +ER+K+R KE +K Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203 Query: 471 -RKKDKKS 477 RKKD+K+ Sbjct: 204 ERKKDRKT 211 Score = 112 bits (280), Expect = 1e-24 Identities = 65/203 (32%), Positives = 112/203 (55%), Gaps = 11/203 (5%) Query: 260 IVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 319 I KP KE E KR RE + + E GK ++K + + + Sbjct: 25 ISKPCTQRESERKKERREREKRKREREK----ERKRERGKKEKKKRKKRERGKERERKRK 80 Query: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD 379 + R++R + + R R + + +K R R + KK K RER + R R KR Sbjct: 81 EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR-- 138 Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREK 439 R+K + KER +EK+R K RER++++ K++ER K ++R++ K+R+K++E+ RER+K Sbjct: 139 -RKKKRRKERKREKERGK-RERKRKKRKKEEREKKRERNR---KERKKERERKERRERKK 193 Query: 440 EHEKDRDKEKEKEQDKEKEREKD 462 E +K+R K+KE+++D++ +R+ D Sbjct: 194 ERKKERRKKKERKKDRKTDRQTD 216 Score = 111 bits (278), Expect = 2e-24 Identities = 58/193 (30%), Positives = 116/193 (60%), Gaps = 4/193 (2%) Query: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 373 S+ + + +RKR + K R R + +++ +R +++ K RE+++ R Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93 Query: 374 RDKRKDTREKIKEKERVK-EKDREKER-EREKEREKEKERGKNKDRDKEREKDREKDKEK 431 R KRK ++K + K+R + E+ ++KER ERE+E ++ +ER + K R K+R K+R+++KE+ Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153 Query: 432 -DREREREKEHEKDRDKEKEK-EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 RER+R+K +++R+K++E+ ++++KERE+ +E ++RKK+++ + + + R Sbjct: 154 GKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDR 213 Query: 490 SRSSSRERRRRRS 502 S R R S Sbjct: 214 QTDSQVFRPLRES 226 Score = 91.3 bits (225), Expect = 2e-18 Identities = 55/187 (29%), Positives = 99/187 (52%), Gaps = 13/187 (6%) Query: 425 REKDKEKDREREREK---EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481 RE +++K+R REREK E EK+R +E+ K ++K+K ++++R KE + KRK+ +K R Sbjct: 32 RESERKKER-REREKRKREREKERKRERGK-KEKKKRKKRERGKERERKRKEREKQRKER 89 Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541 R +R + + R++R R + + K +R++ + + + ++ KKR KER Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149 Query: 542 ISERRERERSTSMRKSS--------NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD 593 ER +RER RK N ++ K++ E+ ++KE KE ++ D Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209 Query: 594 KDAPRTE 600 K +T+ Sbjct: 210 KTDRQTD 216 Score = 90.9 bits (224), Expect = 3e-18 Identities = 44/132 (33%), Positives = 78/132 (59%), Gaps = 4/132 (3%) Query: 302 ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361 ER+ R + K + K RR+R + K R + R ++++R+R K KKR K Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKER-KERERENKQRRERKRKKRRKKKRRKE 146 Query: 362 RERRKSRSRSHSRDKRKDTREKIKEKER---VKEKDREKEREREKEREKEKERGKNKDRD 418 R+R K R + + K++ E+ K++ER ++K+RE++ RE+++E++KER K K+R Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERK 206 Query: 419 KEREKDREKDKE 430 K+R+ DR+ D + Sbjct: 207 KDRKTDRQTDSQ 218 Score = 82.4 bits (202), Expect = 1e-15 Identities = 49/181 (27%), Positives = 90/181 (49%), Gaps = 8/181 (4%) Query: 440 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499 + E +R KE+ + + +++EREK+R +E +K KK +K R + R+ R R+ RR Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90 Query: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559 + R + K K++ + R R KK +++E+ER++ +RRER+R RK Sbjct: 91 EKERR-----KRKKEKKKRERKQRGRRERKKKKERKEREREN-KQRRERKRK-KRRKKKR 143 Query: 560 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 619 ++ K + E+ K K+ KE + +E + K+ + E K + + +E Sbjct: 144 RKERKREKERGKRERKRKKRKKE-EREKKRERNRKERKKERERKERRERKKERKKERRKK 202 Query: 620 K 620 K Sbjct: 203 K 203 Score = 63.2 bits (152), Expect = 7e-10 Identities = 46/189 (24%), Positives = 85/189 (44%), Gaps = 37/189 (19%) Query: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495 +RE E +K+R + +++++++EKER+++R K+ +KRKK R R R Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKK---------------RERGKER 75 Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD--HISERRERERSTS 553 ER+R+ R R R R K+ +KR+KE+ +R RER Sbjct: 76 ERKRKE-REKQRKER-----------------REKERRKRKKEKKKRERKQRGRRERKKK 117 Query: 554 MRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLN 613 + +R+ K++ E+ ++K+ KE KE ++ R + K + + N Sbjct: 118 KERKERERENKQRRERKRKKRRKKKRRKE--RKREKERGKRERKRKKRKKEEREKKRERN 175 Query: 614 EENLSTKTE 622 + + E Sbjct: 176 RKERKKERE 184 Score = 52.8 bits (125), Expect = 1e-06 Identities = 32/147 (21%), Positives = 60/147 (40%) Query: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 535 K T S R R+R R + R R + K K++ R R +++K+R Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86 Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595 ++ R+ +R++E+ RK R+ K+K E+ + K+ + K+ K+ Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146 Query: 596 APRTEENKIQHNGNCQLNEENLSTKTE 622 R +E + + +E K E Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRE 173 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 9/105 (8%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK 332 +E E +R R+ + E + ER G R R + K K R ++ + K Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKER-GKRERKRKKRKKEEREKKRERNRKERKK 181 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377 R R R R +K+R+ K+R K +ER+K R D + Sbjct: 182 ERERKERRER--KKERK------KERRKKKERKKDRKTDRQTDSQ 218 Score = 41.2 bits (95), Expect = 0.003 Identities = 25/113 (22%), Positives = 52/113 (46%), Gaps = 1/113 (0%) Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561 S S P T + +RK R + + +++K+R++ER E+++R++ ++ R Sbjct: 21 SCSHISKPCTQRESERKKERREREKRKREREKERKRERGK-KEKKKRKKRERGKERERKR 79 Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614 +EK K + ++ KE K+ ++ + +E K + N Q E Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132 >gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] Length = 245 Score = 125 bits (313), Expect = 2e-28 Identities = 71/231 (30%), Positives = 129/231 (55%), Gaps = 30/231 (12%) Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385 R+R + R R+K+RR + +KR + +ER++ R + + +RK + K Sbjct: 41 REREIETRKEGKKERESERKKERREREK--RKREREKERKRERGKKEKKGERKKEERERK 98 Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445 ++ R KE +E+E+ K++EK KERG+ KERE+ E+ +E+ +ERER+KE +R Sbjct: 99 KRRREKENKEGEEKEKRKKKEK-KERGRTSKEGKERERKEERKREERKERERKKE---ER 154 Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505 +KE+E+++ K++ER++ KE +E+++K++K R + +R+ R RER+ RR R Sbjct: 155 EKERERKERKKRERKQVGEKE-EERKEKERKER---KKRERNRKERKKERERKERRERKK 210 Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556 R + K+++K+E+++D + RE+ER RK Sbjct: 211 ER--------------------KKKEERKKERQKDRQTNWREKERGKRERK 241 Score = 123 bits (309), Expect = 4e-28 Identities = 72/214 (33%), Positives = 128/214 (59%), Gaps = 15/214 (7%) Query: 368 RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREK 427 R R + RK+ +++ +E ER KE+ ++R+RE+E+E+++ERGK KE++ +R+K Sbjct: 39 REREREIETRKEGKKE-RESERKKERREREKRKREREKERKRERGK-----KEKKGERKK 92 Query: 428 DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 487 ++ + ++R REKE+++ +KEK K+++K KER + SKE E+ +K+++ R + Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEK-KERGRT-SKEGKERERKEERKREERKERERK 150 Query: 488 RRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRE 547 + R RER+ R+ R + + K K + R RN+K++K+E+ER ERRE Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER---KERRE 207 Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNK 581 R++ RK +R KE+ + T+ +EKE K Sbjct: 208 RKKE---RKKKEERK-KERQKDRQTNWREKERGK 237 Score = 119 bits (299), Expect = 6e-27 Identities = 67/208 (32%), Positives = 114/208 (54%), Gaps = 7/208 (3%) Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSR 336 E+ +R RE ++ E ES + ER+ R R K R + +K + K Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96 Query: 337 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 396 R R ++ K KK+ K R S+ K + RE+ KE+ER KE +RE Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE-ERE 155 Query: 397 KEREREKEREKE-KERGKNKDRDKEREKDREKDKE---KDREREREKEHEKDRDKEKEKE 452 KERER++ +++E K+ G+ ++ KE+E+ K +E K+R++ERE++ ++R KE++K+ Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKK 215 Query: 453 QDKEKEREKDRSKEIDEKR--KKDKKSR 478 ++++KER+KDR EK K+++K R Sbjct: 216 EERKKERQKDRQTNWREKERGKRERKER 243 Score = 117 bits (293), Expect = 3e-26 Identities = 60/213 (28%), Positives = 117/213 (54%), Gaps = 5/213 (2%) Query: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 355 + G +E + TR + + +S +++R + + R R + R R++ ++ K Sbjct: 31 QPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGER 90 Query: 356 KKRSKSRE-RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414 KK + R+ RR+ + +K K +++ KE+ R ++ +E+ER+ E++RE+ KER + Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150 Query: 415 K-DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKK 473 K +R+KERE+ K +E+ + E+E+E ++ KE++K + KER+K+R ++ +RKK Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210 Query: 474 DKK---SRTPPRSYNASRRSRSSSRERRRRRSR 503 ++K R R + R R +R R+ R Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKER 243 Score = 115 bits (287), Expect = 2e-25 Identities = 55/207 (26%), Positives = 120/207 (57%), Gaps = 5/207 (2%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSK 352 E E ++G + R R K R + R R++ + + R + + ++++R R K Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK---EREKEK 409 +K +K E ++ R + +++ + ++E KE+ER +E+ RE+ +ERE+ EREKE+ Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEG-KERERKEERKREERKERERKKEEREKER 158 Query: 410 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469 ER + K R++++ ++E+++++ +ER+K ++++KE+E+ + +ER+K+R K+ + Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218 Query: 470 KRKKDKKSRTPPRSYNASRRSRSSSRE 496 K+++ K +T R +R R ++ Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245 Score = 114 bits (285), Expect = 3e-25 Identities = 67/223 (30%), Positives = 122/223 (54%), Gaps = 15/223 (6%) Query: 381 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440 + +I+E+ER E +E ++ERE ER+KE+ +EREK R++++EK+R+RER K+ Sbjct: 35 QSEIREREREIETRKEGKKERESERKKER---------REREK-RKREREKERKRERGKK 84 Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500 +K K++E+E+ K + ++++ E EKRKK +K S R R R+R R Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144 Query: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSND 560 + R + R + +++ + + K+++++EKER ER++RER+ RK + Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKER---KERKKRERNRKERK--KE 199 Query: 561 RDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 R+ KE+ E+ K++E KE +K+ + E + Sbjct: 200 RERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242 Score = 102 bits (253), Expect = 1e-21 Identities = 65/191 (34%), Positives = 103/191 (53%), Gaps = 18/191 (9%) Query: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS------RR 326 KE E KR RE + + E GK E+KG R + K R K + +R Sbjct: 61 KERREREKRKREREK----ERKRERGKK-EKKGERKKEERERKKRRREKENKEGEEKEKR 115 Query: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386 K+ + K R R+ + R++ R + K+R + +E R+ R KR+ + KE Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175 Query: 387 KERVKEKDREKERERE---KEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKE 440 +ER KEK+R++ ++RE KER+KE+ER + ++R KER+K E+ KE+ ++R+ REKE Sbjct: 176 EER-KEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKE 234 Query: 441 HEKDRDKEKEK 451 K KE++K Sbjct: 235 RGKRERKERKK 245 Score = 92.0 bits (227), Expect = 1e-18 Identities = 61/198 (30%), Positives = 109/198 (55%), Gaps = 8/198 (4%) Query: 417 RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476 R++ERE + K+ +K+RE ER+KE ++R+K K +E++KE++RE+ + KE +RKK+++ Sbjct: 39 REREREIETRKEGKKERESERKKER-REREKRK-REREKERKRERGK-KEKKGERKKEER 95 Query: 477 SRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR-SRNKKDKKR 535 R R ++ + R+++ + R+ + K +RK R R R +K ++R Sbjct: 96 ERKKRRREKENKEGEEKEK-RKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154 Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595 EKER+ ER++RER + + +R KE+ E+ KE KE + +E K+ Sbjct: 155 EKERER-KERKKRERK-QVGEKEEERKEKERKERKKRERNRKERKKERERKERRE-RKKE 211 Query: 596 APRTEENKIQHNGNCQLN 613 + EE K + + Q N Sbjct: 212 RKKKEERKKERQKDRQTN 229 Score = 74.7 bits (182), Expect = 2e-13 Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 33/200 (16%) Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 RE+++E + +E +KE E +R KE+ + + +++EREK+R +E +K KK ++ + Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKK------ 92 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS- 543 RER++RR ++ + K+ KK +KER S Sbjct: 93 --------EERERKKRRREKENKEGE----------------EKEKRKKKEKKERGRTSK 128 Query: 544 ERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV-SKEVDDKDAPRTEEN 602 E +ERER RK ++ + K E+ + KE K V KE + K+ R E Sbjct: 129 EGKERERKEE-RKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERK 187 Query: 603 KIQHNGNCQLNEENLSTKTE 622 K + N + E + E Sbjct: 188 KRERNRKERKKERERKERRE 207 Score = 45.4 bits (106), Expect = 2e-04 Identities = 33/135 (24%), Positives = 60/135 (44%), Gaps = 8/135 (5%) Query: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 535 K T + + S S+ ++ + R R T K K++ R ++ +KR Sbjct: 12 KLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKR 71 Query: 536 EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD-------SSVS 588 E+E++ ER ++E+ +K +R K + EK + +EKE K+ + S Sbjct: 72 EREKERKRERGKKEKKGERKKEERERK-KRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130 Query: 589 KEVDDKDAPRTEENK 603 KE + K+ + EE K Sbjct: 131 KERERKEERKREERK 145 Score = 43.1 bits (100), Expect = 8e-04 Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 5/105 (4%) Query: 262 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSK 321 K E + KE E ++ RE + + E K ERK + R R + + + Sbjct: 145 KERERKKEEREKERERKERKKRERKQ---VGEKEEERKEKERKERKKRERNRKERKKERE 201 Query: 322 SHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRK 366 RR+R K R + R + RQKDR+ + ++ + R+ RK Sbjct: 202 RKERRERK--KERKKKEERKKERQKDRQTNWREKERGKRERKERK 244 >gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo sapiens] Length = 434 Score = 119 bits (299), Expect = 6e-27 Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 18/249 (7%) Query: 310 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 369 S R K + S+ S R+ H SRS +RSR R++ H+ RS+S+E R+ S Sbjct: 17 SPDRDKKKEQSEV-SVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHES 75 Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429 + S K K KE K ++R E ++R K KER ++ R R + RE+ Sbjct: 76 KDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-- 133 Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 + R R RE++ + R +E++K + + +ER+K RS+ + KR+ +SR+ R R Sbjct: 134 -RHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSR-----HR 187 Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP---RSRN------KKDKKREKERD 540 R+ SR R R RSR + + R SR+PSP R RN + +R + Sbjct: 188 HRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAK 247 Query: 541 HISERRERE 549 + E+RE+E Sbjct: 248 KLQEQREKE 256 Score = 111 bits (277), Expect = 2e-24 Identities = 70/201 (34%), Positives = 110/201 (54%), Gaps = 10/201 (4%) Query: 371 SHSRDKRKDTRE-KIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429 S RDK+K+ E + + R + R RE++R+ + E K++ R + +E R + K Sbjct: 17 SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESK 76 Query: 430 EKDREREREKEH-EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASR 488 +K ++ + +EH +K+ +K +E+ E +DR K K +K + R+ RS + R Sbjct: 77 DKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKR---KERKSSRGRSHSRSRSRER 133 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 548 R RS SRER++ RSRS R S++ +RK SRS RSR +K + R + R S R R Sbjct: 134 RHRSRSRERKKSRSRSRERKKSRSRSRERKKSRS---RSRERKRRIRSRSRSR-SRHRHR 189 Query: 549 ERSTSMRKSSNDRDGKEKLEK 569 RS S R S RD K+++EK Sbjct: 190 TRSRS-RTRSRSRDRKKRIEK 209 Score = 110 bits (274), Expect = 5e-24 Identities = 72/267 (26%), Positives = 126/267 (47%), Gaps = 25/267 (9%) Query: 264 PEMTPQAAAKELEE----VMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 319 PE T K+ E+ V R + S + E + ++ +G + RS +RSK Sbjct: 13 PEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKE--- 69 Query: 320 SKSHSRRKRSQSKHRSRSHN---RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDK 376 + H + +S KH+S HN S + ++R S + R K +ER+ SR RSHSR + Sbjct: 70 GRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSR 129 Query: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436 ++ R R + RER+K R + +ER K++ R +ER+K R + +E+ R R Sbjct: 130 SRERRH------------RSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR-RI 176 Query: 437 REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK-SRTP-PRSYNASRRSRSSS 494 R + + R + + + + + + R +DR K I++ R+ + SRTP P + + + Sbjct: 177 RSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQ 236 Query: 495 RERRRRRSRSSSRSPRTSKTIKRKSSR 521 RR R+ + K + K + Sbjct: 237 EALARRLERAKKLQEQREKEMVEKQKQ 263 Score = 102 bits (254), Expect = 1e-21 Identities = 58/189 (30%), Positives = 101/189 (53%), Gaps = 10/189 (5%) Query: 296 ESGKSNERKGGRSRSHTRSKSR----SSSKSHSRRKRSQSKH-RSRSHNRSRSRQKDRRR 350 +S K ++ + + H+ K R SS R KR + K R RSH+RSRSR++ R R Sbjct: 78 KSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-RHR 136 Query: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKE 410 S+S +K+S+SR R + +SRS SR+++K + K R++ + R + R R + R + + Sbjct: 137 SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRT 196 Query: 411 RGKNKDRDKEREKDREKDKEKDRERE----REKEHEKDRDKEKEKEQDKEKEREKDRSKE 466 R +++DR K EK R + R R + D + + ++ K+ ++ R KE Sbjct: 197 RSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKE 256 Query: 467 IDEKRKKDK 475 + EK+K+ + Sbjct: 257 MVEKQKQQE 265 Score = 59.3 bits (142), Expect = 1e-08 Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 20/177 (11%) Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKER------EKDRSKEIDEKRKKDKKSRTPPRS 483 + +R+ ++ DRDK+KE+ + R + RS+ + KRK D + R Sbjct: 5 DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGR----- 59 Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR-----NKKDKKREKE 538 RSRS S+E RR S+ S S+ K S R R N +D+ + KE Sbjct: 60 ---KHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKE 116 Query: 539 RDHISER-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594 R R R RS R S R+ K+ ++ K + ++E S S+ + K Sbjct: 117 RKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERK 173 Score = 32.3 bits (72), Expect = 1.3 Identities = 17/82 (20%), Positives = 33/82 (40%) Query: 528 RNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587 + D+ ++KE+ +S + R S R+ K K + + + +KE Sbjct: 15 KTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHE 74 Query: 588 SKEVDDKDAPRTEENKIQHNGN 609 SK+ K E N +H+ + Sbjct: 75 SKDKSSKKHKSEEHNDKEHSSD 96 >gi|20070262 TNF receptor-associated factor 3 interacting protein 1 isoform 1 [Homo sapiens] Length = 691 Score = 116 bits (290), Expect = 7e-26 Identities = 92/331 (27%), Positives = 163/331 (49%), Gaps = 26/331 (7%) Query: 297 SGKSNERKGGRS-RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS---K 352 +G+ E KG S S ++ + + R ++ R + + RS +DR++ K Sbjct: 130 AGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELK 189 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDR-EKEREREKEREKE 408 K R K +++ K++ +R R+ RE+ K + R ++KDR +ER+R+ ER+KE Sbjct: 190 EDRKPREKDKDKEKAKENGGNRH-REGERERAKARARPDNERQKDRGNRERDRDSERKKE 248 Query: 409 KER----GKNKD--RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK- 461 ER GK K+ RD++RE+DR+K K++DR R + EH D D+EK +E DK +++ Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308 Query: 462 --DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 519 + SK++ + KD K+ T + ++R S+S + + +RRS++S R I KS Sbjct: 309 SGEMSKKLSDGTFKDSKAET--ETEISTRASKSLTTKTSKRRSKNSVEG-RKEDNISAKS 365 Query: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579 S N + +E I + STS+ ++ E ++ N T ++ + Sbjct: 366 LDSIVSGINN--EPNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGDS 423 Query: 580 NKEPDSSVSKEVDDK-DAPRTEE--NKIQHN 607 + + DK + P T E N++ N Sbjct: 424 TSDAEGDAGPAGQDKSEVPETPEIPNELSSN 454 Score = 96.3 bits (238), Expect = 8e-20 Identities = 83/366 (22%), Positives = 146/366 (39%), Gaps = 84/366 (22%) Query: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358 K+ + R +T + + K S + + K + + R + KD+ ++K R Sbjct: 152 KNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELKEDRKPREKDKDKEKAKENGGNR 211 Query: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418 + ER ++++R+ ++R+ R +E+DR+ ER++E ER+ E + K + RD Sbjct: 212 HREGERERAKARARPDNERQKDRGN-------RERDRDSERKKETERKSEGGKEKERLRD 264 Query: 419 KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK 475 ++RE+DR+K K++DR R + EH D D+EK +E DK +++ + SK++ + KD Sbjct: 265 RDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDS 324 Query: 476 KSRTPPR-SYNASRRSRSSSRERR-------RRRSRSSSRS--------------PRTSK 513 K+ T S AS+ + + +RR R+ S++S T+ Sbjct: 325 KAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNISAKSLDSIVSGINNEPNQETTTS 384 Query: 514 TIKRKSSR-------------------SPSPRSRNKKDKKREKERD-------------- 540 I K + P+P + K D + E D Sbjct: 385 EIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPET 444 Query: 541 -----HISERRER--------------ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNK 581 +S R +R SM DR G K N + N+ Sbjct: 445 PEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNE 504 Query: 582 EPDSSV 587 E D V Sbjct: 505 EDDQFV 510 Score = 87.8 bits (216), Expect = 3e-17 Identities = 65/261 (24%), Positives = 113/261 (43%), Gaps = 37/261 (14%) Query: 366 KSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDR 425 K R+ SR + D + +E+ RV + ++ KER ++R + KE K+ Sbjct: 137 KGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDR-----KQKEELKED 191 Query: 426 EKDKEKDREREREKEHEKDRDKEKEKEQDK-----EKEREKDRSKEIDEKRKKDKKSRTP 480 K +EKD+++E+ KE+ +R +E E+E+ K + ER+KDR + R ++K T Sbjct: 192 RKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNR-ERDRDSERKKETE 250 Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERD 540 +S + R R+R R R + R R K + D REK R+ Sbjct: 251 RKSEGGKEKERLRDRDRERDRDKGKDRDRRRVK------------NGEHSWDLDREKNRE 298 Query: 541 HISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600 H ++ S M K +D K+ + T + + SK + K + R Sbjct: 299 HDKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTR---------ASKSLTTKTSKRRS 349 Query: 601 ENKIQHNGNCQLNEENLSTKT 621 +N ++ E+N+S K+ Sbjct: 350 KNSVEGR-----KEDNISAKS 365 Score = 34.7 bits (78), Expect = 0.27 Identities = 42/184 (22%), Positives = 76/184 (41%), Gaps = 15/184 (8%) Query: 290 SAAIEPESGKSN--ERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKD 347 SA++ E+ + N E++ G S S + + + S + S N R + Sbjct: 403 SASLRCENIQPNPTEKQKGDSTSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPG 462 Query: 348 RRRSKSPHKKRSKSRER-RKSRS-----------RSHSRDKRKDTREKIKEKERVKEKDR 395 R P KR S E + RS SH+ D +D + ++ ++ E Sbjct: 463 SARPAPPRVKRQDSMEALQMDRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMS- 521 Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK 455 E E E E+E++ G + E +KD EK ++ + E+E+ + K+++ K Sbjct: 522 EIEMVTAVELEEEEKHGGLVKKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSK 581 Query: 456 EKER 459 E E+ Sbjct: 582 EIEK 585 Score = 33.1 bits (74), Expect = 0.79 Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 13/130 (10%) Query: 483 SYNASRRSRSSSRERRRRRSRSSSRSPR-TSKTIKRKSSRSPSPRSRNKKDK--KREKER 539 S +A RR + + + R+ +SRS +K ++ + SR +N +D+ KER Sbjct: 121 SDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRV----HKNTEDRGDAEIKER 176 Query: 540 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK---EKEHNK---EPDSSVSKEVDD 593 +R+++E RK KEK ++N + E+E K PD+ K+ + Sbjct: 177 STSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGN 236 Query: 594 KDAPRTEENK 603 ++ R E K Sbjct: 237 RERDRDSERK 246 >gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] Length = 2817 Score = 116 bits (290), Expect = 7e-26 Identities = 61/202 (30%), Positives = 121/202 (59%), Gaps = 6/202 (2%) Query: 325 RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384 +++R Q S + R+R R+++ R + ++++ E+ K +++ + E+I Sbjct: 446 KQRRRQQSEISAAVERARKRREEEER-RMEEQRKAACAEKLKRLDEKLGILEKQPSPEEI 504 Query: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKD 444 +E+ER KE++REKE E+E+E+E+EKER K+++R +E+EK+ EK++EK RE E+E++ EK+ Sbjct: 505 REREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKE 564 Query: 445 RDKEKEKEQDKEKEREKDRSKEID-EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503 ++ E++KE++KE ++ K++ KE + EK ++ + + PR N E S Sbjct: 565 KELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESE----NSC 620 Query: 504 SSSRSPRTSKTIKRKSSRSPSP 525 + P ++ +S + +P Sbjct: 621 NKEEEPVFTRQDSNRSEKEATP 642 Score = 111 bits (277), Expect = 2e-24 Identities = 79/277 (28%), Positives = 137/277 (49%), Gaps = 23/277 (8%) Query: 264 PEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSH 323 P + Q A E +E+ K+ R QS ISAA+E + K E + R ++ K Sbjct: 431 PFPSKQQVADE-DEIWKQRRRQQSEISAAVE-RARKRREEEERRMEEQRKAACAEKLKRL 488 Query: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383 + K S R R R+K+R R K K++ + RE +E+ Sbjct: 489 DEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE-----------------KER 531 Query: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEK 443 K++ER +EK++E E+E+EK+RE EKER + K+++ ER+K++EK+ +K +E+E+E E EK Sbjct: 532 EKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEK 591 Query: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSR 503 +R+K +EK + +E E K+ E K P + S RS + Sbjct: 592 EREKLEEKIEPREPNLEPMVEKQ--ESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEP 649 Query: 504 SSSRSPRTS--KTIKRKSSRSPSPRSRNKKDKKREKE 538 S PR + ++ +S PR + ++++ ++++ Sbjct: 650 ESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQ 686 Score = 82.0 bits (201), Expect = 1e-15 Identities = 50/209 (23%), Positives = 100/209 (47%), Gaps = 4/209 (1%) Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437 K R + E E+ R++ E E+ E++++ + + EK +K+ E R Sbjct: 446 KQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIR 505 Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497 E+E EK+R++EKE E+++E+EREK+R K+ + +++K+K+ + R +E+ Sbjct: 506 EREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEK 565 Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 557 R + + + K +++ +K + RE + + E++E E S + + Sbjct: 566 ELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEE 625 Query: 558 S-NDRDGKEKLEKNSTSLKEKEHNKEPDS 585 R + EK +T + H EP+S Sbjct: 626 PVFTRQDSNRSEKEATPV---VHETEPES 651 Score = 63.2 bits (152), Expect = 7e-10 Identities = 63/361 (17%), Positives = 159/361 (44%), Gaps = 39/361 (10%) Query: 264 PEMTPQAAAKELEEVMKRVREA-QSFISAAIEPE-----SGKSNERKGGRSRSHTRSKSR 317 P + + KEL++ EA + + A +E + + ++ +G S S+ + Sbjct: 294 PSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQ 353 Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS-------- 369 S S + + ++ S + + S+ + +K P+ K + R + S Sbjct: 354 GSKASENNENKKETDEVSNTKSSSQIPAQPSV-AKVPYGKGPSFNQERGTSSHLPPPPKL 412 Query: 370 --RSHSRDKRKDTREK---IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424 + H R+ + K++V ++D ++ R ++ E + + R +E E+ Sbjct: 413 LAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERR 472 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 E+ ++ + ++ EK EK+ ++ +ERE+++ +E +++ +K+++ Sbjct: 473 MEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQE-------- 524 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544 + R RE+ R R + + + +R+ + + ++++EKE++ + + Sbjct: 525 ----QEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKE-LQK 579 Query: 545 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD----KDAPRTE 600 +E+E+ + K + EK+E +L+ +E ++S +KE + +D+ R+E Sbjct: 580 MKEQEKECELEKEREKLE--EKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSE 637 Query: 601 E 601 + Sbjct: 638 K 638 Score = 57.8 bits (138), Expect = 3e-08 Identities = 76/326 (23%), Positives = 124/326 (38%), Gaps = 36/326 (11%) Query: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 365 GR R S+ RS S+ R R R H R + +D + ++ H R+R Sbjct: 1187 GRGRGEYYSRGRSYRGSYGGRGRG-----GRGHTRDYPQYRDNK-PRAEHIPSGPLRQRE 1240 Query: 366 KSRSRSHSRD------KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK 419 +S +RS S D +R+ + + E +K+ + + K +ER +NK K Sbjct: 1241 ESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVK 1300 Query: 420 EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT 479 + + + R EK + +D DK K K + + R + R Sbjct: 1301 PHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTF------RRGGRD 1354 Query: 480 PPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS------PRSRNKKDK 533 P R SR S+ RR R + +PR S+ K + P P + +K+ Sbjct: 1355 P-----GGRPSRPST--LRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPP 1407 Query: 534 KREKERDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVD 592 K E++ D ER R+R T R D+ + +L + + K E P + V Sbjct: 1408 KFERKFDPARERPRRQRPT--RPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVA 1465 Query: 593 DKDAPRTEENKIQHNGNCQLNEENLS 618 + P I N L+ +N S Sbjct: 1466 QE--PVNTLGDISGNKTPDLSNQNSS 1489 Score = 52.4 bits (124), Expect = 1e-06 Identities = 49/272 (18%), Positives = 108/272 (39%), Gaps = 20/272 (7%) Query: 347 DRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKERE 406 D + S SP K + S ++ S ++ K D K ++ + + K Sbjct: 338 DEQGSNSP--KENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPS 395 Query: 407 KEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 466 +ERG + + ++ DR+ + ++ E + K+R + +S E Sbjct: 396 FNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQS-E 454 Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS--SRSPS 524 I ++ +K R ERR R ++ + + + ++ + PS Sbjct: 455 ISAAVERARKRR--------------EEEERRMEEQRKAACAEKLKRLDEKLGILEKQPS 500 Query: 525 PRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPD 584 P ++++++E+ER+ E+ + + R+ +R +++ E K++E KE Sbjct: 501 PEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERK 560 Query: 585 SSVSKEVDDKDAPRTEENKI-QHNGNCQLNEE 615 KE++ + E K+ + C+L +E Sbjct: 561 QEKEKELERQKEKEKELQKMKEQEKECELEKE 592 Score = 51.6 bits (122), Expect = 2e-06 Identities = 59/254 (23%), Positives = 107/254 (42%), Gaps = 42/254 (16%) Query: 262 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKS-RSSS 320 +P + T A +E E+V Q I+AA E + +H ++ R SS Sbjct: 816 EPQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLE--------AHPKADFIRESS 867 Query: 321 KSHSRRKRSQSKHRSRSHNRSRSRQK------DRRRSKSPHKKRSKSRERRKSRSRSHSR 374 ++ ++ S+S R H+ + Q D++ +P ++R + E + SR RS S Sbjct: 868 EAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQPSRKRSVSH 927 Query: 375 DKR-----------------KDTREKIKEKERVKEKDREKERE---REKEREKEKE--RG 412 K T I KE ++ + + ++E R E K ++ + Sbjct: 928 GSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKS 987 Query: 413 KNKDRDKEREKDREKDKEKDRERER----EKEHEKDRDKEKEKEQDKEKER-EKDRSKEI 467 K++ R R +++ DR R +K +D +E+E+ ++KE E+ EK K + Sbjct: 988 KSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVV 1047 Query: 468 DEKRKKDKKSRTPP 481 + K +KK PP Sbjct: 1048 VKPEKTEKKDLPPP 1061 Score = 40.0 bits (92), Expect = 0.006 Identities = 77/401 (19%), Positives = 139/401 (34%), Gaps = 87/401 (21%) Query: 265 EMTPQAAAKELEEVMKRVREAQSFI---SAAIEPESGKSNERKGGRSRSHTRSKSRSSSK 321 E ++ + + E V KR R+ S S E S K + KG + R +++ K Sbjct: 1241 ESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVK 1300 Query: 322 SHSRRK-----RSQSKHRSRSHNRSRSRQKD---------RRRSKSPHKKRSKSRERRKS 367 HS K R ++ + + R + K RR ++ + R S Sbjct: 1301 PHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPS 1360 Query: 368 RSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK-------------EREKEKERGKN 414 R + R +D + ++ E K +D E R E+ ER+ + R + Sbjct: 1361 RPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADKRPPKFERKFDPARERP 1420 Query: 415 KDRDKEREKDREKDKEKDRERERE---KEHE----------------------------- 442 + + R ++K R RERE K +E Sbjct: 1421 RRQRPTRPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKT 1480 Query: 443 KDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP--------------PRSYNASR 488 D + +Q E+ S + +E+R++D+K P ++ Sbjct: 1481 PDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAK 1540 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIK--RKSSRSPSPRSRNKKDKKREKE-------- 538 RS SS R R+ R ++ P++ + R RS P K+ ++ Sbjct: 1541 RSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDL 1600 Query: 539 -RDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 578 + +E + + +K+S D GK++ + K KE Sbjct: 1601 INGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKE 1641 Score = 33.9 bits (76), Expect = 0.46 Identities = 28/131 (21%), Positives = 50/131 (38%), Gaps = 15/131 (11%) Query: 422 EKDREKDKEKDREREREKEHEKDRDKEKEKEQD-------KEKEREKDRSKEIDEKRKKD 474 +++R E R+R H + ++ ++++ K R D + I+ +K Sbjct: 908 QEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKP 967 Query: 475 KKSR--------TPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526 KK P + Y + +R R RR + R R S IK+ R Sbjct: 968 KKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEE 1027 Query: 527 SRNKKDKKREK 537 +K+K+ EK Sbjct: 1028 REQRKEKEGEK 1038 >gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapiens] Length = 820 Score = 115 bits (287), Expect = 2e-25 Identities = 85/274 (31%), Positives = 142/274 (51%), Gaps = 36/274 (13%) Query: 315 KSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSR 374 K R +S S RKRS R+ +R R R +DR+ S S +KR +SR+RR+ SRS SR Sbjct: 9 KDRDASPSKEERKRS------RTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSR 62 Query: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDR- 433 +R K E+ER R KERER+KER++ K K++DRDK+ + R+KD+++ Sbjct: 63 -----SRSKSAERER-----RHKERERDKERDRNK---KDRDRDKDGHR-RDKDRKRSSL 108 Query: 434 --EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE---KRKKDKKSRTPPRSYNASR 488 R ++ + KDRD +K++E + ++ K + ++E K+K ++++ P+ + + Sbjct: 109 SPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAE 168 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 548 R E +RR + R + +RK + R + +E+ER ER ER Sbjct: 169 R----EAEALKRRQQEVEERQRMLEE-ERKKRKQFQDLGRKMLEDPQERERRERRERMER 223 Query: 549 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582 E + + D +G++K+ + KE KE Sbjct: 224 ETN-----GNEDEEGRQKIREEKDKSKELHAIKE 252 Score = 92.8 bits (229), Expect = 8e-19 Identities = 73/282 (25%), Positives = 127/282 (45%), Gaps = 22/282 (7%) Query: 313 RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR-KSRSR 370 R +SR+ + R R R S + R +RSR R++ RS+S + +S RERR K R R Sbjct: 20 RKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERER 79 Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKER---EREKEREKEKERGKNKDRDKEREKDREK 427 RD+ K R++ K+ R ++KDR++ R K+ + K+R KD + E + K Sbjct: 80 DKERDRNKKDRDRDKDGHR-RDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPK 138 Query: 428 DKEKDREREREKEHEKDRDKEKEK---EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484 + E K+ ++ + K K + ++E E K R +E++E+++ ++ R + + Sbjct: 139 AQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQF 198 Query: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544 R + R RR R T+ + R + +++K + KE I E Sbjct: 199 QDLGRKMLEDPQERERRERRERMERETN------GNEDEEGRQKIREEKDKSKELHAIKE 252 Query: 545 R-------RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579 R R R R + RK + D E + L ++ H Sbjct: 253 RYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERH 294 Score = 84.7 bits (208), Expect = 2e-16 Identities = 81/363 (22%), Positives = 158/363 (43%), Gaps = 44/363 (12%) Query: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 331 A +E KR R + +S S +RK RSR R SRS S+S S+ + Sbjct: 13 ASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERER 72 Query: 332 KHRSRSHNRSRSR-QKDRRRSKSPH------KKRSKSRERRKSRSRSHSRDKRKDTREKI 384 +H+ R ++ R R +KDR R K H K+ S S R K RD +KD ++ Sbjct: 73 RHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEH 132 Query: 385 KEK----------ERVKEKDREKERERE----KEREKEKERGKNKDRD-KEREKDREKDK 429 +K E + +K E+E E + + E+E E K + ++ +ER++ E+++ Sbjct: 133 GDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEER 192 Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 +K ++ + + +E+E+ + +E+ + E +E R+K ++ + + +A + Sbjct: 193 KKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKE 252 Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK----------------KDK 533 ++RRR + R +S +P + + K + Sbjct: 253 RYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQ 312 Query: 534 KREKER---DHISERR---ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587 KRE+ R D + +RR E+E+ + + ++ K++ + S K+ + + D + Sbjct: 313 KREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRI 372 Query: 588 SKE 590 +E Sbjct: 373 FRE 375 Score = 82.4 bits (202), Expect = 1e-15 Identities = 52/201 (25%), Positives = 95/201 (47%), Gaps = 18/201 (8%) Query: 410 ERGKNKDRD-----KEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDK--EKEREKD 462 E KDRD +ER++ R D+E+DR+R+R+ KDR + + +++ + + R + Sbjct: 4 ELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRS 63 Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522 RSK + +R+ ++ R R N R R RR + + SS SP K K Sbjct: 64 RSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFK------ 117 Query: 523 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582 SR +D K+++E +H +++ + + S+ + + +E+ E L + E E Sbjct: 118 ----SRKDRDSKKDEEDEH-GDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAE 172 Query: 583 PDSSVSKEVDDKDAPRTEENK 603 +EV+++ EE K Sbjct: 173 ALKRRQQEVEERQRMLEEERK 193 Score = 70.1 bits (170), Expect = 6e-12 Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 17/191 (8%) Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497 E +KDRD KE E+ RS+ D +R +D+ ++ P + R R R Sbjct: 4 ELADKKDRDASPSKE-------ERKRSRTPDRERDRDRDRKSSPS------KDRKRHRSR 50 Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 557 RRR S SRS SK+ +R+ R + + K++++RD RR+++R S Sbjct: 51 DRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSP 110 Query: 558 SNDRDGKEKLEKNSTSLKEKEH-NKEPDS---SVSKEVDDKDAPRTEENKIQHNGNCQLN 613 +D K + +++S +E EH +K+P + S+ + + K A E K + + Sbjct: 111 GRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAERE 170 Query: 614 EENLSTKTEAV 624 E L + + V Sbjct: 171 AEALKRRQQEV 181 Score = 43.1 bits (100), Expect = 8e-04 Identities = 53/264 (20%), Positives = 99/264 (37%), Gaps = 17/264 (6%) Query: 271 AAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ 330 A +E E + +R +E + E + ERK + K + RR+R + Sbjct: 167 AEREAEALKRRQQEVE-------ERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRE 219 Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-----RKSRSRSHSRDKRKDTREKIK 385 R + N ++ R K K+ +ER +K R H D++ Sbjct: 220 RMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDAS 279 Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445 E + KER + + + G + + K + D + R EKE E+ R Sbjct: 280 EDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEAR 339 Query: 446 DKEKEKEQDKEKEREKDRS-KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504 ++ K++ K++ ++ S K++DE +D + S ++ R + Sbjct: 340 LRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSIT----TKGGKIPNPIRSWKD 395 Query: 505 SSRSPRTSKTIKRKSSRSPSPRSR 528 SS P + I + + P+P R Sbjct: 396 SSLPPHILEVIDKCGYKEPTPIQR 419 >gi|213385278 TNF receptor-associated factor 3 interacting protein 1 isoform 2 [Homo sapiens] Length = 625 Score = 114 bits (284), Expect = 4e-25 Identities = 89/321 (27%), Positives = 155/321 (48%), Gaps = 36/321 (11%) Query: 297 SGKSNERKGGRS-RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS---K 352 +G+ E KG S S ++ + + R ++ R + + RS +DR++ K Sbjct: 130 AGEKGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRGDAEIKERSTSRDRKQKEELK 189 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERV---KEKDR-EKEREREKEREKE 408 K R K +++ K++ +R R+ RE+ K + R ++KDR +ER+R+ ER+KE Sbjct: 190 EDRKPREKDKDKEKAKENGGNRH-REGERERAKARARPDNERQKDRGNRERDRDSERKKE 248 Query: 409 KER----GKNKD--RDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREK- 461 ER GK K+ RD++RE+DR+K K++DR R + EH D D+EK +E DK +++ Sbjct: 249 TERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSAS 308 Query: 462 --DRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 519 + SK++ + KD K+ T + ++R S+S + + +RRS++S TS + Sbjct: 309 SGEMSKKLSDGTFKDSKAET--ETEISTRASKSLTTKTSKRRSKNSVEGDSTSDA---EG 363 Query: 520 SRSPSPRSRNKKDKKREKERDHISERR-------------ERERSTSMRKSSNDRDGKEK 566 P+ + +++ + E + S R +R SM DR G K Sbjct: 364 DAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSGK 423 Query: 567 LEKNSTSLKEKEHNKEPDSSV 587 N + N+E D V Sbjct: 424 TVSNVITESHNSDNEEDDQFV 444 Score = 100 bits (248), Expect = 5e-21 Identities = 79/326 (24%), Positives = 155/326 (47%), Gaps = 22/326 (6%) Query: 309 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 368 + + ++ +S+S ++ + SR H + R + K+RS SR+R++ Sbjct: 133 KGEVKGRASLTSRSQELDNKNVREEESRVHKNTEDR------GDAEIKERSTSRDRKQKE 186 Query: 369 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN---KDR-DKEREKD 424 R R EK K+KE+ KE + RE E+ER K + R N KDR ++ER++D Sbjct: 187 ELKEDRKPR----EKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRD 242 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK----EIDEKRKKDKKSRTP 480 E+ KE +R+ E KE E+ RD+++E+++DK K+R++ R K D R+K+++ P Sbjct: 243 SERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKP 302 Query: 481 PRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN--KKDKKREKE 538 + +S + + S++ + + +++ K ++++ RS+N + D + E Sbjct: 303 EKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGDSTSDAE 362 Query: 539 RDHISERRERERSTSMRKSSNDRDGK-EKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAP 597 D +++ + N+ ++ + ++ K DS + ++D + Sbjct: 363 GDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQMDRSGSG 422 Query: 598 RTEENKIQHNGNCQLNEENLSTKTEA 623 +T N I + N NEE+ EA Sbjct: 423 KTVSNVITESHNSD-NEEDDQFVVEA 447 Score = 33.1 bits (74), Expect = 0.79 Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 13/130 (10%) Query: 483 SYNASRRSRSSSRERRRRRSRSSSRSPR-TSKTIKRKSSRSPSPRSRNKKDK--KREKER 539 S +A RR + + + R+ +SRS +K ++ + SR +N +D+ KER Sbjct: 121 SDDAVRRVLAGEKGEVKGRASLTSRSQELDNKNVREEESRV----HKNTEDRGDAEIKER 176 Query: 540 DHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLK---EKEHNK---EPDSSVSKEVDD 593 +R+++E RK KEK ++N + E+E K PD+ K+ + Sbjct: 177 STSRDRKQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGN 236 Query: 594 KDAPRTEENK 603 ++ R E K Sbjct: 237 RERDRDSERK 246 Score = 33.1 bits (74), Expect = 0.79 Identities = 49/224 (21%), Positives = 86/224 (38%), Gaps = 16/224 (7%) Query: 248 DRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGR 307 D+P K + S+ + K +K E R ++S + + S S E G Sbjct: 300 DKPEKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVE---GD 356 Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RK 366 S S + + + S + S N R + R P KR S E + Sbjct: 357 STSDAEGDAGPAGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAPPRVKRQDSMEALQM 416 Query: 367 SRS-----------RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415 RS SH+ D +D + ++ ++ E E E E E+E++ G Sbjct: 417 DRSGSGKTVSNVITESHNSDNEEDDQFVVEAAPQLSEMS-EIEMVTAVELEEEEKHGGLV 475 Query: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 459 + E +KD EK ++ + E+E+ + K+++ KE E+ Sbjct: 476 KKILETKKDYEKLQQSPKPGEKERSLFESAWKKEKDIVSKEIEK 519 >gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] Length = 1007 Score = 113 bits (283), Expect = 5e-25 Identities = 117/427 (27%), Positives = 182/427 (42%), Gaps = 106/427 (24%) Query: 296 ESGKSNERKGGRSRSHTRSKSRSSS-----KSHSRRKRSQSKHRSRSHNRS--------- 341 E G+ +E+ +RS TRS S + +KRS+S+ + R+ +RS Sbjct: 146 EEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGI 205 Query: 342 --------RSRQKDRRRSKSPHKKRSKSRERRKSRS---RSHSRDK----RKDTREKIKE 386 RS+ K+R++SKSP K+ + RKS+S R S++K R T +K+K Sbjct: 206 EIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKI 265 Query: 387 KERVKEKDREKE----------------------------REREKERE-KEKERGKNKDR 417 +++ K KDR+K R R KER+ K E K K Sbjct: 266 EDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKP 325 Query: 418 DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKS 477 K KD KE +R R R K +DK + + RS ++++R K KS Sbjct: 326 IKSPSKDASSGKE-NRSPSRRPGRSPKRRSLSPKPRDKSR---RSRSPLLNDRRSKQSKS 381 Query: 478 RTPPRSYNASRRSRSSSRERRR---------------------RRSRSSSRSP------- 509 P R+ + RR++S S ER+R RR RS SP Sbjct: 382 --PSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPT 439 Query: 510 -RTSKTIKRKSSRSP-----SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 563 R S++ R+ SRSP SPR R++ ++R++ R S R R RS R+ + Sbjct: 440 RRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKV 499 Query: 564 KEKLEKNSTS--LKEKEHNKEPDSSVSKEVDDKDAPR-TEENKIQHNGNCQ-----LNEE 615 KE K S S +K ++ + D+ +V+++D E+ +IQ Q + Sbjct: 500 KEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDS 559 Query: 616 NLSTKTE 622 N+S +E Sbjct: 560 NMSVPSE 566 Score = 97.1 bits (240), Expect = 4e-20 Identities = 93/369 (25%), Positives = 165/369 (44%), Gaps = 43/369 (11%) Query: 255 HSNNAIVKPPEMTPQAAAKELE----EVMKRVREAQSFISAAIEPESGKSNERKG-GRSR 309 H I+ + + AK + +++ + + ++ I A ++ E + + G G Sbjct: 78 HKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLIL 137 Query: 310 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 369 S S + H +++++ +RS + + S + + +K KKRSKSR + ++R Sbjct: 138 QGYESGSEEEGEIH---EKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRH 194 Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429 RS + K K E +KEK R + KER+K K K R K +++ R+ Sbjct: 195 RSDKK-KSKGGIEIVKEKTT---------RSKSKERKKSKSPSK---RSKSQDQARKSKS 241 Query: 430 EKDREREREK-EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD--KKSRTPPRSYNA 486 R R +EK + +K K +DK K +++ +S I+E R +D KKSR+P Sbjct: 242 PTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGK 301 Query: 487 SRRSRSSSRERRRRRSRS------------SSRSPRTSKTIKRKSSRSPSPRSRNKK--D 532 S+ RS S+ER+ +RS + + S + +++ R+ RSP RS + K D Sbjct: 302 SKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRD 361 Query: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEP-----DSSV 587 K R +++RR ++ + R S R K + + E+ P D + Sbjct: 362 KSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDIL 421 Query: 588 SKEVDDKDA 596 S+ KDA Sbjct: 422 SRRERSKDA 430 Score = 89.4 bits (220), Expect = 9e-18 Identities = 82/337 (24%), Positives = 137/337 (40%), Gaps = 36/337 (10%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353 +PE +N K + S+ +S +K HSR K+ + KHRS+ S ++D+ + K Sbjct: 12 QPEMEDANSEKSINEENGEVSEDQSQNK-HSRHKKKKHKHRSKHKKHKHSSEEDKDK-KH 69 Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK-EREKEKERG 412 HK + K +R++ S R K+ + + +D EK+R K E + E G Sbjct: 70 KHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALL--EDLEKQRALIKAELDNELMEG 127 Query: 413 K-----------------------NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449 K K R+ R R + E K K R K + Sbjct: 128 KVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSR 187 Query: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509 KE+ + + +K I+ ++K +S++ R + S RS S+++ R+ + R Sbjct: 188 SKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRR 247 Query: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS------TSMRKSSNDR-- 561 K K +S + +K K K+ I+E R R+R +R S DR Sbjct: 248 SQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRS 307 Query: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598 KE+ K S + KEK+ K P S +++ R Sbjct: 308 RSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSR 344 Score = 72.8 bits (177), Expect = 9e-13 Identities = 72/308 (23%), Positives = 135/308 (43%), Gaps = 39/308 (12%) Query: 340 RSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER 399 R + +D KS +++ + E + S + K+ R K K+ + E+D++K+ Sbjct: 10 REQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKH 69 Query: 400 EREKEREKEKERGKNKDRDKEREKDREKDKEKD----REREREK---EHEKDRDKEKEKE 452 + + + +K K + DKE ++ K D + E+++ + E D + + K Sbjct: 70 KHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKV 129 Query: 453 QD------KEKEREKDRSKEIDEKRKKDKKSRTPPRS-----------YNASRRSRSSSR 495 Q + E + EI EK + +S T S +RS+S S+ Sbjct: 130 QSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK 189 Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPS-PRSRNKKDKKREKERDHISERRERERSTSM 554 ER R RS +S + +K K++RS S R ++K KR K +D + + +S ++ Sbjct: 190 ERTRHRS-DKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQD----QARKSKSPTL 244 Query: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614 R+ S ++ GK ++ T K K +K SK D K +P E++ + G + Sbjct: 245 RRRSQEKIGK---ARSPTDDKVKIEDK------SKSKDRKKSPIINESRSRDRGKKSRSP 295 Query: 615 ENLSTKTE 622 +L K++ Sbjct: 296 VDLRGKSK 303 Score = 67.0 bits (162), Expect = 5e-11 Identities = 65/275 (23%), Positives = 124/275 (45%), Gaps = 27/275 (9%) Query: 301 NERKGGRSRSHTRSKS---RSSSKSHSRRKRSQSKHRSRSHNRSRSR-----QKDRRRSK 352 N+R+ +S+S +R+ S R+ S+S RKR + + R S R+R R +++R + Sbjct: 372 NDRRSKQSKSPSRTLSPGRRAKSRS-LERKRREPERRRLSSPRTRPRDDILSRRERSKDA 430 Query: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 412 SP + S +R R +S R SR + +R + + +DR + R R + R + + RG Sbjct: 431 SPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGR-RSRSRLRRRSRSRG 489 Query: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472 + R + + K+ DK K E K ++ + ++ D E+E E+ + E+R+ Sbjct: 490 GRRRRSRSKVKE---DKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEE----ALIEQRR 542 Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD 532 +++ Y A + S E +S + +RSP ++R ++ Sbjct: 543 IQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAA----------DV 592 Query: 533 KKREKERDHISERRERERSTSMRKSSNDRDGKEKL 567 K+ E+E E + + M N+ ++KL Sbjct: 593 KEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKL 627 Score = 53.9 bits (128), Expect = 4e-07 Identities = 61/234 (26%), Positives = 102/234 (43%), Gaps = 29/234 (12%) Query: 245 MFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERK 304 + DR K + S + + P +A ++ LE +R E + S P + R+ Sbjct: 370 LLNDRRSKQSKSPSRTLSPGR---RAKSRSLER-KRREPERRRLSSPRTRPRDDILSRRE 425 Query: 305 GGRSRSHTRSKSRSSSKSHS-RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK----KRS 359 RSK S S R+RS+S R RS + R + RRRS+SP + +RS Sbjct: 426 --------RSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRS 477 Query: 360 KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDK 419 +SR RR+SRSR +R+ +R K+KE +K + E K ++ +D D Sbjct: 478 RSRLRRRSRSRG---GRRRRSRSKVKE-----DKFKGSLSEGMKVEQESSSDDNLEDFDV 529 Query: 420 EREKDREKDKEKDRER----EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469 E E + +++ +R ++ K +D + E + + RS D+ Sbjct: 530 EEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDD 583 >gi|52426743 cisplatin resistance-associated overexpressed protein [Homo sapiens] Length = 432 Score = 112 bits (280), Expect = 1e-24 Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%) Query: 366 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424 +SR H K+ KIK E +KEK R++ E +++ +KE+ + ++R+KERE++ Sbjct: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 483 RE+ + K R E E+E E+ RD+E+ K + + + R R+ + R +D K+SR+ Sbjct: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319 Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 542 R R SR R RRRSRS RS R ++ R RS +SR++K K R K RD Sbjct: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371 Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602 +R+ +E+ ++ S+D+ K+S +E E ++ SKE D K+ Sbjct: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421 Query: 603 KIQHNGNCQLN 613 I+ G+ Q N Sbjct: 422 DIKSEGDTQSN 432 Score = 104 bits (259), Expect = 3e-22 Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%) Query: 269 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317 +A +EL+E +++ +E Q E E + + R R K R Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283 Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377 + + +R RS+S+H SR+ +R SR +D +RS+S ++RS+SR+RR RSRSH R +R Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341 Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437 K R + +++ R K +DR+ + R K R++E++R K+K+++K R D +K K RE+ Sbjct: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398 Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSK 465 + E KE + + + E +S+ Sbjct: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426 Score = 102 bits (253), Expect = 1e-21 Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 347 + +S + G + + + K+ RKR++ R + R ++++ Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262 Query: 348 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407 R R + K+R + ER K R+R R++RK +R + + R DR R R+ +R + Sbjct: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318 Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 466 +ER +++ RD+ R + ++ + K R R R++ K RD++ K + K ++RE+DR SKE Sbjct: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378 Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516 +++ DKKS + SR +S + S + + TS+ IK Sbjct: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424 Score = 97.8 bits (242), Expect = 3e-20 Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%) Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403 ++K R+R++ P + +E+++ R R++ ++ RE+ K R +E++REKER R++ Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287 Query: 404 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462 ER K + R ++ R +R R +D ++ R RER + +DR + + ++ + K R + Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347 Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522 R R RS SR+R+ + RS SR + K K R Sbjct: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383 Query: 523 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 570 + + K REK+ D +E +E + + +S D + + N Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432 Score = 67.4 bits (163), Expect = 4e-11 Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%) Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 332 E KR R S + +S + K RSR S +R + R S+SH RS+ K Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 HRSRS +R RS+ +DR+ +K RSKSR+R + R + K K+ R +K VK Sbjct: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393 Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432 REK+ E KE + KN+ + E D + + Sbjct: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432 >gi|19923485 cisplatin resistance-associated overexpressed protein [Homo sapiens] Length = 432 Score = 112 bits (280), Expect = 1e-24 Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%) Query: 366 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424 +SR H K+ KIK E +KEK R++ E +++ +KE+ + ++R+KERE++ Sbjct: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264 Query: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 483 RE+ + K R E E+E E+ RD+E+ K + + + R R+ + R +D K+SR+ Sbjct: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319 Query: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 542 R R SR R RRRSRS RS R ++ R RS +SR++K K R K RD Sbjct: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371 Query: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602 +R+ +E+ ++ S+D+ K+S +E E ++ SKE D K+ Sbjct: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421 Query: 603 KIQHNGNCQLN 613 I+ G+ Q N Sbjct: 422 DIKSEGDTQSN 432 Score = 104 bits (259), Expect = 3e-22 Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%) Query: 269 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317 +A +EL+E +++ +E Q E E + + R R K R Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283 Query: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377 + + +R RS+S+H SR+ +R SR +D +RS+S ++RS+SR+RR RSRSH R +R Sbjct: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341 Query: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437 K R + +++ R K +DR+ + R K R++E++R K+K+++K R D +K K RE+ Sbjct: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398 Query: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSK 465 + E KE + + + E +S+ Sbjct: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426 Score = 102 bits (253), Expect = 1e-21 Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 347 + +S + G + + + K+ RKR++ R + R ++++ Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262 Query: 348 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407 R R + K+R + ER K R+R R++RK +R + + R DR R R+ +R + Sbjct: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318 Query: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 466 +ER +++ RD+ R + ++ + K R R R++ K RD++ K + K ++RE+DR SKE Sbjct: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378 Query: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516 +++ DKKS + SR +S + S + + TS+ IK Sbjct: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424 Score = 97.8 bits (242), Expect = 3e-20 Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%) Query: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403 ++K R+R++ P + +E+++ R R++ ++ RE+ K R +E++REKER R++ Sbjct: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287 Query: 404 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462 ER K + R ++ R +R R +D ++ R RER + +DR + + ++ + K R + Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347 Query: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522 R R RS SR+R+ + RS SR + K K R Sbjct: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383 Query: 523 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 570 + + K REK+ D +E +E + + +S D + + N Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432 Score = 67.4 bits (163), Expect = 4e-11 Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%) Query: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 332 E KR R S + +S + K RSR S +R + R S+SH RS+ K Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342 Query: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 HRSRS +R RS+ +DR+ +K RSKSR+R + R + K K+ R +K VK Sbjct: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393 Query: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432 REK+ E KE + KN+ + E D + + Sbjct: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432 >gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens] Length = 1341 Score = 111 bits (278), Expect = 2e-24 Identities = 77/277 (27%), Positives = 139/277 (50%), Gaps = 25/277 (9%) Query: 223 RFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKP-------PEMTPQAAAKEL 275 +F ++A+Q+ L ++ + DRP + I +P P PQ E Sbjct: 1080 KFLCADYAEQDE----LDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ 1135 Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335 E + VRE + +E +ER+ R + +SRS S+ R++R++SK + Sbjct: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK- 1194 Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395 +S +K++ + + P K + K+ + D++ KE ER + Sbjct: 1195 ------KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLT-DSQIVQKEAERAERAKE 1247 Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR---DKEKEKE 452 ++R +E+E E++KER K +R++ R+ +REK +E RER+RE+E E++R D+++++E Sbjct: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE 1307 Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 +D+E+ RE+DR D KR +SR+ P RR Sbjct: 1308 RDRERGRERDRR---DTKRHSRSRSRSTPVRDRGGRR 1341 Score = 98.6 bits (244), Expect = 2e-20 Identities = 54/214 (25%), Positives = 118/214 (55%), Gaps = 25/214 (11%) Query: 311 HTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR 370 H R++ R ++ + + + R R+ DR + + + RS+SR+RR+ + R Sbjct: 1130 HPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR-KER 1188 Query: 371 SHSRDKRKDTREKIKEKERVKEKDR----------------------EKEREREKEREKE 408 + S++K+ + +EK +E+ K D +KE ER + ++ Sbjct: 1189 AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKER 1248 Query: 409 KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER-EKDRSKEI 467 ++R K ++ ++++E+++E ++E++R+ EREK E R++++E+E+++E++R ++DR +E Sbjct: 1249 EKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRER 1308 Query: 468 DEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501 D +R +++ R R ++ SR + R+R RR Sbjct: 1309 DRERGRERDRRDTKR-HSRSRSRSTPVRDRGGRR 1341 Score = 96.7 bits (239), Expect = 6e-20 Identities = 106/453 (23%), Positives = 182/453 (40%), Gaps = 85/453 (18%) Query: 103 EESKALSLLAPAPTMTSLMPGAGLLPIPTPNPL--TTLGV-----SLSSLGAIPAAALDP 155 EE K P P S+ LP P + + TLG S+S + + +D Sbjct: 939 EEEKEPEAEPPVPPQVSVEVA---LPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDD 995 Query: 156 NIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMA 215 + T ++P PP +I V++ NL + T QL E + G + Sbjct: 996 PVRT-AQVPSPPR---------GKISNIVHISNL-VRPFTLGQLKELLGRTGTLVEEAFW 1044 Query: 216 GDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKEL 275 D+ + FV ++ +V A+A + G VK P+ P+ + Sbjct: 1045 IDKIKS--HCFVTYS---TVEEAVATRTALHG-------------VKWPQSNPKFLCADY 1086 Query: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335 E E ++ S E +G H H R ++ + + Sbjct: 1087 AEQ----DELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAV 1142 Query: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395 R R R+ +RR ++ + + R RSRS SRD+R+ R K KEK K + + Sbjct: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK---KSEKK 1199 Query: 396 EKEREREKER--------------------------EKEKERGKNKDRDKEREKDREKDK 429 EK +E + +KE ER + ++R K++E+++ Sbjct: 1200 EKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEE 1259 Query: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE-KRKKDKKSRTPPRSYNASR 488 +K+RE+E E+E + ++EK +E +E++RE++R +E D R +D++ Sbjct: 1260 QKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE------------ 1307 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSR 521 R R RER RR ++ SRS S ++ + R Sbjct: 1308 RDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340 Score = 83.6 bits (205), Expect = 5e-16 Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 36/228 (15%) Query: 381 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440 R + +E+ER +++ ERERE ER + + DRDK RE R + + +DR R KE Sbjct: 1132 RAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR---KE 1187 Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY------------NASR 488 K ++K+ EK KEK +E+ +K +D+ +K K + P Y A R Sbjct: 1188 RAKSKEKKSEK---KEKAQEEPPAKLLDDLFRKTKAA---PCIYWLPLTDSQIVQKEAER 1241 Query: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RE 547 R+ RE+RR+ + R + + R RN++ +REK R+H ER RE Sbjct: 1242 AERAKEREKRRKEQEEEEQKEREKE----------AERERNRQ-LEREKRREHSRERDRE 1290 Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595 RER + DRD + E+ +++ K S S+ +D Sbjct: 1291 RERERERDRGDRDRDRERDRERGRE--RDRRDTKRHSRSRSRSTPVRD 1336 Score = 81.6 bits (200), Expect = 2e-15 Identities = 66/219 (30%), Positives = 109/219 (49%), Gaps = 34/219 (15%) Query: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKERE-KDREKD 428 R+ R++ + RE+ E+ER E+ ERE +R+K +E +++ R ++R K+R K Sbjct: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS 1191 Query: 429 KEKDREREREKEHEK-----DRDKEKEK------------EQDKEKEREK-DRSKEIDEK 470 KEK E++ + + E D K K Q +KE E+ +R+KE +++ Sbjct: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251 Query: 471 RKKDKKSRTPPRSYNASR-RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 529 RK+ ++ R A R R+R RE+RR SR R +R+ R R R+ Sbjct: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRER------ERERERDRGDRDRD 1305 Query: 530 K-KDKKREKERDHISERRE---RERSTSMRKSSNDRDGK 564 + +D++R +ERD +R R RST +R DR G+ Sbjct: 1306 RERDRERGRERDRRDTKRHSRSRSRSTPVR----DRGGR 1340 Score = 58.2 bits (139), Expect = 2e-08 Identities = 85/405 (20%), Positives = 153/405 (37%), Gaps = 36/405 (8%) Query: 162 EIPQPPLMGNVDPS---KIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDE 218 ++P+ P DPS K+ E+ G Q L +Q G K + + Sbjct: 41 KLPKMPEAVGTDPSTSRKMAELEEVTLDGK-PLQALRVTDLKAALEQRGLAKSGQKSALV 99 Query: 219 TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEV 278 + +E ++S P A G+ + + + K E+ Q +E E Sbjct: 100 KRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREA 159 Query: 279 MKRVREAQSF----------ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328 + + EA + +++ + P+ S ER H S +SSS S + Sbjct: 160 AE-LEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH--SPRKSSSISEEKGDS 216 Query: 329 SQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387 K R SR RQ + + S+ + + SR+ D+ T E+ +E+ Sbjct: 217 DDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276 Query: 388 ERVKEKDREKEREREKEREKE-------KERGKNKDRDKEREKDREKDKEKDREREREKE 440 E +E D E+E + E ++ +E KE G+ R K E E+ K R +E+E Sbjct: 277 EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKT--RSQEQEVL 334 Query: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS----RE 496 R ++E K + + KE+ +++ R S +S+S S E Sbjct: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE 394 Query: 497 RRRRRS-----RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536 R++ S ++ T + K + SP P + +++ E Sbjct: 395 DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIE 439 Score = 55.5 bits (132), Expect = 1e-07 Identities = 57/294 (19%), Positives = 117/294 (39%), Gaps = 10/294 (3%) Query: 267 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS-SKSHSR 325 TP AA + ++ + + + SFI +E + +R +R + S+ S+ Sbjct: 116 TPHAAFQPNSQIGEEMSQ-NSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMI 174 Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385 + S R + SP K S S E+ S + +R+ +R + Sbjct: 175 HPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQA 234 Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445 ++ E + E E ++E R + DR+ + E++ E E E E+E +++ Sbjct: 235 RAAKLSEGSQPAEEEEDQETPSRNLRVR-ADRNLKTEEEEE-------EEEEEEEDDEEE 286 Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505 + + E ++ +E K+ +E +E + + R S+ R R RS+ Sbjct: 287 EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346 Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559 +R ++ + K ++ SP +++ K + S+ R T RK ++ Sbjct: 347 ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS 400 Score = 55.5 bits (132), Expect = 1e-07 Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 44/327 (13%) Query: 300 SNERKGGRSRSHT--------------RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSR 344 S E+K GR SHT S+S SSS S SR R RS SRSH+ RS+ Sbjct: 551 SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSK 610 Query: 345 QKD----------RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD 394 Q+D R R K + S+SR R +SRSRS S + RK + ++ Sbjct: 611 QRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS-----RDSS 665 Query: 395 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 454 ++ +E K+R + R + E EK Q Sbjct: 666 TSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE---SAEKHVTQR 722 Query: 455 KEKEREKDRSKEIDEKR----KKDKKSRTPPRSYNASRRSRSSSRERRR-----RRSRSS 505 + ER + E +E + + S T S R + E+ +R Sbjct: 723 LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPE 782 Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS--MRKSSNDRDG 563 + P I + S P + ++K+E +R+ S + + ++D +G Sbjct: 783 NDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEG 842 Query: 564 KEKLEKNSTSLKEKEHNKEPDSSVSKE 590 + K K+P S++ E Sbjct: 843 GQPGRKRRWGASTATTQKKPSISITTE 869 Score = 48.9 bits (115), Expect = 1e-05 Identities = 46/234 (19%), Positives = 97/234 (41%), Gaps = 28/234 (11%) Query: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430 S R + + +R ++ + E+ + + E+ ++ E+ R + K E + ++E Sbjct: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249 Query: 431 KDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489 +D+E R DR+ + E+E+++E+E E+D +E E + +KSR P Sbjct: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEE--EGDDEGQKSREAPILKEFKEE 307 Query: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549 R +K + P++R+++ + E+ + E Sbjct: 308 GEEIPR-------------------VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA- 347 Query: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603 RKS R +EK K ++ L+E+E + + ++ PR E++ Sbjct: 348 -----RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396 Score = 48.5 bits (114), Expect = 2e-05 Identities = 65/341 (19%), Positives = 123/341 (36%), Gaps = 38/341 (11%) Query: 282 VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-----SKHRSR 336 +R Q ++ A + + + G RS S +RS+SRS S+S S R S+ S Sbjct: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666 Query: 337 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 396 S+ ++ + + P + + ++ + S S R+ ++ + EK + E Sbjct: 667 SYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPE 726 Query: 397 KEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD-- 454 + ++ E E+ + + + E + + E+ EKE E E D Sbjct: 727 RGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVP 786 Query: 455 -------------------KEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495 E E +K+ S KRK S T S Sbjct: 787 EPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPG 846 Query: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR 555 +RR + +++ + S +I +S +S P + ++ + H + R E T Sbjct: 847 RKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDL-HADDSRISEDETERN 905 Query: 556 KSSNDRDGKEKLEKNSTSL-----------KEKEHNKEPDS 585 D K+ + T + +E+E KEP++ Sbjct: 906 GDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEA 946 Score = 40.8 bits (94), Expect = 0.004 Identities = 79/386 (20%), Positives = 137/386 (35%), Gaps = 56/386 (14%) Query: 261 VKPPEMT---PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317 VKP EM P+ ++E +EV++R A + + + K ++ S + R Sbjct: 314 VKPEEMMDERPKTRSQE-QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEER 372 Query: 318 SSSKSHSRRKRSQSKHRSR-SHNRSRSR-----QKDRRRSKSPHKKRSKSRERRKSRSRS 371 S +++S+S R + +R ++ ++ ++P +K + Sbjct: 373 EIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQL 432 Query: 372 HSRDKRK--------------------DTREKIKEKERVK------EKDREKEREREKER 405 HS ++ + DTRE + + V+ + + E Sbjct: 433 HSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPA 492 Query: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465 EK E K D K+ + E +R + + +E + +E K S Sbjct: 493 EKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSL 552 Query: 466 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525 E E R+ R ++ S S S SRS SRSP +S SRS SP Sbjct: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSS------GSRSHSP 606 Query: 526 RSRNKKDKKREKERDH-----------ISERRERERSTSMRKSSNDRDGKEKLEKNSTSL 574 ++D + + + SE R R RS S SSN R + L + Sbjct: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSR---KSLSPGVSRD 663 Query: 575 KEKEHNKEPDSSVSKEVDDKDAPRTE 600 + + D S +EV P+ + Sbjct: 664 SSTSYTETKDPSSGQEVATPPVPQLQ 689 Score = 37.4 bits (85), Expect = 0.042 Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 28/245 (11%) Query: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445 +K+ E DR + K E +G ++ K+ ++++ + ++ Sbjct: 515 QKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSA 574 Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN---ASRRSRSSSRERRRRRS 502 D + + RS+ D +S +P RS A R+ ++ R R + S Sbjct: 575 DSSSSRSSSSSSSSSRSRSRSPDSS---GSRSHSPLRSKQRDVAQARTHANPRGRPKMGS 631 Query: 503 RSSSRS-------PRTSKTIKRKS-----SRSPSPRSRNKKDKKREKE-------RDHIS 543 RS+S S R++ + RKS SR S KD +E + + Sbjct: 632 RSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVC 691 Query: 544 ERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA--PRTEE 601 E +ER ++S + E EK+ T + E P ++E + A P+T E Sbjct: 692 EPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERG-SPKKCEAEEAEPPAATQPQTSE 750 Query: 602 NKIQH 606 + H Sbjct: 751 TQTSH 755 Score = 37.0 bits (84), Expect = 0.054 Identities = 39/199 (19%), Positives = 78/199 (39%), Gaps = 19/199 (9%) Query: 426 EKDKEKDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRS------------KEIDEKRK 472 EK +E R+R ERE + ++ + +D+ E S E++ R Sbjct: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201 Query: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSSRSPSPRSRN 529 +KS + S + ERR R +R++ S + + + +PS R Sbjct: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRV 261 Query: 530 KKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589 + D+ + E + E E E + D +G++ E ++E + P + Sbjct: 262 RADRNLKTEEE---EEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318 Query: 590 EVDDKDAPRTEENKIQHNG 608 +D++ R++E ++ G Sbjct: 319 MMDERPKTRSQEQEVLERG 337 Score = 31.2 bits (69), Expect = 3.0 Identities = 24/117 (20%), Positives = 48/117 (41%), Gaps = 1/117 (0%) Query: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505 D ++ E D + DR E + + + PP + +R + R+ Sbjct: 1085 DYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVRE 1144 Query: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562 + R + +R+ +RS R+K ++ + R +RR +ER+ S K S ++ Sbjct: 1145 QWAEREREMERRERTRSEREWDRDKV-REGPRSRSRSRDRRRKERAKSKEKKSEKKE 1200 Score = 30.4 bits (67), Expect = 5.1 Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 12/83 (14%) Query: 523 PSPRSRNKKDKKREK--ERDHISERRERERS----------TSMRKSSNDRDGKEKLEKN 570 P R ++ RE+ ER+ ERRER RS R S RD + K Sbjct: 1131 PRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK 1190 Query: 571 STSLKEKEHNKEPDSSVSKEVDD 593 S K ++ K + +K +DD Sbjct: 1191 SKEKKSEKKEKAQEEPPAKLLDD 1213 >gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5 [Homo sapiens] Length = 748 Score = 110 bits (276), Expect = 3e-24 Identities = 92/331 (27%), Positives = 158/331 (47%), Gaps = 33/331 (9%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353 + K + + G R H R + + + R + + + Q+ R+ K Sbjct: 5 DDRDSKRDSLEEGELRDH-RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63 Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413 H+K K +E+R R RSHS + K R +KEKER E+ R++ RE + + +E ER K Sbjct: 64 HHRKDEKRKEKR--RHRSHSAEGGKHAR--VKEKEREHER-RKRHREEQDKARREWERQK 118 Query: 414 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRK 472 ++ +E + RE+D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+ Sbjct: 119 RREMAREHSR-RERDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARRE 176 Query: 473 KDKKSRTPPRSYN----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI------------- 515 RT Y+ AS SRS R R R R P + + Sbjct: 177 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 236 Query: 516 --KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS 573 +RK+S + S + + + E+E + E E E STS + S + + +E+ E+ T Sbjct: 237 DSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETG 291 Query: 574 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604 +E +++ VS+E +D R EN + Sbjct: 292 SNSEEASEQSAEEVSEEEMSEDEERENENHL 322 Score = 101 bits (251), Expect = 2e-21 Identities = 86/315 (27%), Positives = 153/315 (48%), Gaps = 47/315 (14%) Query: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK---------IKEKERVKEKDR 395 Q D R SK + + R+ R + +S +R+D+ E IK +++ K++ Sbjct: 3 QSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK 62 Query: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK-EKEKEQD 454 R+ EK +EK + R + + K + KEK+RE ER K H +++DK +E E+ Sbjct: 63 VHHRKDEKRKEKRRHRSHSAEGGK-----HARVKEKEREHERRKRHREEQDKARREWERQ 117 Query: 455 KEKE-------REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR-----RRRS 502 K +E RE+DR ++++ KR++++K R + + + ERR RR Sbjct: 118 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 177 Query: 503 RSSSRSPRTSKTIKRKS---SRSP--SPRSR-----NKKDKKREK--ERDHISERR---E 547 + R+ R + K K+ SRSP PR R +K K EK ERD +S+ + + Sbjct: 178 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 237 Query: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHN 607 ER TS +SS+ G E+ +E+E +E + S S+E ++++ EE + + Sbjct: 238 SERKTSSAESSSAESGSGSEEE-----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 292 Query: 608 GNCQLNEENLSTKTE 622 + + +E++ +E Sbjct: 293 NSEEASEQSAEEVSE 307 Score = 72.4 bits (176), Expect = 1e-12 Identities = 65/305 (21%), Positives = 120/305 (39%), Gaps = 85/305 (27%) Query: 261 VKPPEMTPQAAAKEL-----EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT--- 312 +KPP+ Q + KE +E K R +S + + K ER+ R + H Sbjct: 51 IKPPQ---QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQ 107 Query: 313 --------RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER 364 R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ER Sbjct: 108 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 167 Query: 365 RKSRSR-----SHSRDKRKDTREKIK-------------------------EKERVKEKD 394 RK R +H R R+D +K+K ++E+++E+D Sbjct: 168 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 227 Query: 395 --------------------------REKEREREKEREKEKERGKNKDRDKEREKDREKD 428 E E E+E E+E+E +++ ++E E++ E++ Sbjct: 228 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEE 287 Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSR 478 +E E E + E+E +D+E+E E DR E+ +++ Sbjct: 288 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 347 Query: 479 TPPRS 483 TP S Sbjct: 348 TPQSS 352 Score = 62.8 bits (151), Expect = 9e-10 Identities = 62/237 (26%), Positives = 109/237 (45%), Gaps = 21/237 (8%) Query: 369 SRSHSRDKRKDTREKIKEKE-RVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREK 427 S+S RD ++D+ E+ + ++ R++ R RE E +RG+ D + + Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSME---DRGEEDDSLAIKPPQQMS 58 Query: 428 DKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNAS 487 KEK R+ EK EK R + E K R K++ +E E+RK+ ++ + R Sbjct: 59 RKEKVHHRKDEKRKEKRRHRSHSAEGGKHA-RVKEKERE-HERRKRHREEQDKARREWER 116 Query: 488 RRSRSSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546 ++ R +RE RR R R + ++RK R R + +K+++ +KER+ +E R Sbjct: 117 QKRREMAREHSRRERDR--------LEQLERKRERERKMREQ-QKEQREQKERERRAEER 167 Query: 547 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK--EVDDKDAPRTEE 601 +ER S++ R +E S +K ++ P + E+ D P EE Sbjct: 168 RKEREARREVSAHHRTMREDY---SDKVKASHWSRSPPRPPRERFELGDGRKPVKEE 221 Score = 43.5 bits (101), Expect = 6e-04 Identities = 47/217 (21%), Positives = 83/217 (38%), Gaps = 47/217 (21%) Query: 426 EKDKEKDRERERE-KEHEKD---RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPP 481 ++D ++D E E ++H + R+ +E E E+D S I ++ +K + Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV-- 63 Query: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541 R +E+RR RS S+ K + +EKER+H Sbjct: 64 -----HHRKDEKRKEKRRHRSHSAEGG---------------------KHARVKEKEREH 97 Query: 542 ISERRERERSTSMRK--------------SSNDRDGKEKLE-KNSTSLKEKEHNKEPDSS 586 +R RE R+ S +RD E+LE K K +E KE Sbjct: 98 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQ 157 Query: 587 VSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTEA 623 +E ++ + E + + + + + E+ S K +A Sbjct: 158 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 194 >gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2 [Homo sapiens] Length = 782 Score = 110 bits (276), Expect = 3e-24 Identities = 92/331 (27%), Positives = 158/331 (47%), Gaps = 33/331 (9%) Query: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKS 353 + K + + G R H R + + + R + + + Q+ R+ K Sbjct: 39 DDRDSKRDSLEEGELRDH-RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 97 Query: 354 PHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGK 413 H+K K +E+R R RSHS + K R +KEKER E+ R++ RE + + +E ER K Sbjct: 98 HHRKDEKRKEKR--RHRSHSAEGGKHAR--VKEKEREHER-RKRHREEQDKARREWERQK 152 Query: 414 NKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRK 472 ++ +E + RE+D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+ Sbjct: 153 RREMAREHSR-RERDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARRE 210 Query: 473 KDKKSRTPPRSYN----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI------------- 515 RT Y+ AS SRS R R R R P + + Sbjct: 211 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 270 Query: 516 --KRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTS 573 +RK+S + S + + + E+E + E E E STS + S + + +E+ E+ T Sbjct: 271 DSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETG 325 Query: 574 LKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604 +E +++ VS+E +D R EN + Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENENHL 356 Score = 103 bits (256), Expect = 6e-22 Identities = 87/334 (26%), Positives = 160/334 (47%), Gaps = 47/334 (14%) Query: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK-- 383 +++ + K + R + D R SK + + R+ R + +S +R+D+ E Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRG 77 Query: 384 -------IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436 IK +++ K++ R+ EK +EK + R + + K + KEK+RE E Sbjct: 78 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK-----HARVKEKEREHE 132 Query: 437 REKEHEKDRDK-EKEKEQDKEKE-------REKDRSKEIDEKRKKDKKSRTPPRSYNASR 488 R K H +++DK +E E+ K +E RE+DR ++++ KR++++K R + + Sbjct: 133 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 192 Query: 489 RSRSSSRERR-----RRRSRSSSRSPRTSKTIKRKS---SRSP--SPRSR-----NKKDK 533 + ERR RR + R+ R + K K+ SRSP PR R +K Sbjct: 193 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 252 Query: 534 KREK--ERDHISERR---ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588 K EK ERD +S+ + + ER TS +SS+ G E+ +E+E +E + S S Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE-----EEEEEEEEEEGSTS 307 Query: 589 KEVDDKDAPRTEENKIQHNGNCQLNEENLSTKTE 622 +E ++++ EE + + + + +E++ +E Sbjct: 308 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 341 Score = 72.4 bits (176), Expect = 1e-12 Identities = 65/305 (21%), Positives = 120/305 (39%), Gaps = 85/305 (27%) Query: 261 VKPPEMTPQAAAKEL-----EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT--- 312 +KPP+ Q + KE +E K R +S + + K ER+ R + H Sbjct: 85 IKPPQ---QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQ 141 Query: 313 --------RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER 364 R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ER Sbjct: 142 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 201 Query: 365 RKSRSR-----SHSRDKRKDTREKIK-------------------------EKERVKEKD 394 RK R +H R R+D +K+K ++E+++E+D Sbjct: 202 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 261 Query: 395 --------------------------REKEREREKEREKEKERGKNKDRDKEREKDREKD 428 E E E+E E+E+E +++ ++E E++ E++ Sbjct: 262 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEE 321 Query: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSR 478 +E E E + E+E +D+E+E E DR E+ +++ Sbjct: 322 EETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG 381 Query: 479 TPPRS 483 TP S Sbjct: 382 TPQSS 386 Score = 58.5 bits (140), Expect = 2e-08 Identities = 59/257 (22%), Positives = 103/257 (40%), Gaps = 51/257 (19%) Query: 385 KEKERVKEKD---REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441 K+ +VK D +EK+R +E+E + E +R KN D ++D ++D ++ E + Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-----DRDSKRDSLEEGELRDHRME 59 Query: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501 R+ +E E E+D S I ++ +K + R +E+RR R Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV-------HHRKDEKRKEKRRHR 112 Query: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK----- 556 S S+ K + +EKER+H +R RE R+ Sbjct: 113 SHSAEGG---------------------KHARVKEKEREHERRKRHREEQDKARREWERQ 151 Query: 557 ---------SSNDRDGKEKLE-KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606 S +RD E+LE K K +E KE +E ++ + E + + Sbjct: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211 Query: 607 NGNCQLNEENLSTKTEA 623 + + + E+ S K +A Sbjct: 212 SAHHRTMREDYSDKVKA 228 >gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4 [Homo sapiens] Length = 737 Score = 107 bits (267), Expect = 3e-23 Identities = 86/308 (27%), Positives = 153/308 (49%), Gaps = 36/308 (11%) Query: 331 SKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKS-----------RSRSHSRDKRKD 379 SK S R + + SP+++ +R + SR RKD Sbjct: 9 SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 68 Query: 380 TREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD-RERERE 438 + K K+ RVKEK+RE ER + E++K R R+ ER+K RE +E RER+R Sbjct: 69 EKRKEKKHARVKEKEREHERRKRHREEQDKAR-----REWERQKRREMAREHSRRERDRL 123 Query: 439 KEHEKDRDKE-KEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRER 497 ++ E+ R++E K +EQ KE+ +K+R + +E R+K++++R +++ + R S + + Sbjct: 124 EQLERKRERERKMREQQKEQREQKERERRAEE-RRKEREARREVSAHHRTMREDYSDKVK 182 Query: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR---ERERSTSM 554 SRS R PR + + R P K++K E ERD +S+ + + ER TS Sbjct: 183 ASHWSRSPPRPPR--ERFELGDGRKP------VKEEKME-ERDLLSDLQDISDSERKTSS 233 Query: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNE 614 +SS+ G E+ +E+E +E + S S+E ++++ EE + + + + +E Sbjct: 234 AESSSAESGSGSEEE-----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE 288 Query: 615 ENLSTKTE 622 ++ +E Sbjct: 289 QSAEEVSE 296 Score = 103 bits (257), Expect = 5e-22 Identities = 86/318 (27%), Positives = 147/318 (46%), Gaps = 29/318 (9%) Query: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKS 367 S+S R R S + R S R +DR + + RK Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 61 Query: 368 RSRSHSRDKRKDTRE-KIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDRE 426 + +KRK+ + ++KEKER E+ R++ RE + + +E ER K ++ +E + RE Sbjct: 62 KVHHRKDEKRKEKKHARVKEKEREHER-RKRHREEQDKARREWERQKRREMAREHSR-RE 119 Query: 427 KDKEKDREREREKEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKDKKSRTPPRSYN 485 +D+ + ER+RE+E K R+++KE+ + KE+ER ++R KE + +R+ RT Y+ Sbjct: 120 RDRLEQLERKRERE-RKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 178 Query: 486 ----ASRRSRSSSRERRRRRSRSSSRSPRTSKTI---------------KRKSSRSPSPR 526 AS SRS R R R R P + + +RK+S + S Sbjct: 179 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 238 Query: 527 SRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSS 586 + + + E+E + E E E STS + S + + +E+ E+ T +E +++ Sbjct: 239 AESGSGSEEEEEEE---EEEEEEGSTS--EESEEEEEEEEEEEEETGSNSEEASEQSAEE 293 Query: 587 VSKEVDDKDAPRTEENKI 604 VS+E +D R EN + Sbjct: 294 VSEEEMSEDEERENENHL 311 Score = 71.2 bits (173), Expect = 3e-12 Identities = 62/297 (20%), Positives = 118/297 (39%), Gaps = 80/297 (26%) Query: 261 VKPPEMTPQAAA-------KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSH-T 312 +KPP+ + K E+ RV+E + E E K + + ++R Sbjct: 51 IKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKER------EHERRKRHREEQDKARREWE 104 Query: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSR-- 370 R K R ++ HSRR+R + + R R R ++ ++ + ++ ++ ERRK R Sbjct: 105 RQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR 164 Query: 371 ---SHSRDKRKDTREKIK-------------------------EKERVKEKD-------- 394 +H R R+D +K+K ++E+++E+D Sbjct: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224 Query: 395 ------------------REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436 E E E+E E+E+E +++ ++E E++ E+++E E Sbjct: 225 SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 284 Query: 437 REKEHEKDRDKEKEKEQDKEKEREK----------DRSKEIDEKRKKDKKSRTPPRS 483 E + E+E +D+E+E E DR E+ +++ TP S Sbjct: 285 EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSS 341 Score = 43.1 bits (100), Expect = 8e-04 Identities = 39/186 (20%), Positives = 74/186 (39%), Gaps = 20/186 (10%) Query: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTS 512 Q +++ ++D ++E +D + R N+ R S +R + + P+ Sbjct: 3 QSDDRDSKRD---SLEEGELRDHRMEITIR--NSPYRREDSMEDRGEEDDSLAIKPPQQM 57 Query: 513 KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK--------------SS 558 ++ R R K + +EKER+H +R RE R+ S Sbjct: 58 SRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSR 117 Query: 559 NDRDGKEKLE-KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENL 617 +RD E+LE K K +E KE +E ++ + E + + + + + E+ Sbjct: 118 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 177 Query: 618 STKTEA 623 S K +A Sbjct: 178 SDKVKA 183 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.307 0.124 0.332 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,010,981 Number of Sequences: 37866 Number of extensions: 1379166 Number of successful extensions: 108939 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 1607 Number of HSP's successfully gapped in prelim test: 1191 Number of HSP's that attempted gapping in prelim test: 14961 Number of HSP's gapped (non-prelim): 27195 length of query: 624 length of database: 18,247,518 effective HSP length: 108 effective length of query: 516 effective length of database: 14,157,990 effective search space: 7305522840 effective search space used: 7305522840 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.