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Search of human proteins with 22749187
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749187 putative adenylate kinase-like protein C9orf98
[Homo sapiens]
(479 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749187 putative adenylate kinase-like protein C9orf98 [Homo... 967 0.0
gi|53832001 adenylate kinase 3-like 1 isoform 7 [Homo sapiens] 92 8e-19
gi|53832003 adenylate kinase 3-like 1 isoform 5 [Homo sapiens] 92 8e-19
gi|8051579 adenylate kinase 3-like 1 isoform 6 [Homo sapiens] 92 8e-19
gi|19923437 adenylate kinase 3 [Homo sapiens] 89 9e-18
gi|4502013 adenylate kinase 2 isoform a [Homo sapiens] 82 1e-15
gi|7524346 adenylate kinase 2 isoform b [Homo sapiens] 82 1e-15
gi|28144897 adenylate kinase 5 isoform 1 [Homo sapiens] 68 2e-11
gi|28144899 adenylate kinase 5 isoform 2 [Homo sapiens] 68 2e-11
gi|237858799 adenylate kinase domain containing 1 isoform 1 [Hom... 57 5e-08
gi|4502011 adenylate kinase 1 [Homo sapiens] 55 1e-07
gi|21450759 adenylate kinase domain containing 1 isoform 2 [Homo... 55 1e-07
gi|7706497 UMP-CMP kinase 1 isoform a [Homo sapiens] 48 2e-05
gi|148727333 adenylate kinase 7 [Homo sapiens] 38 0.023
gi|22749117 hypothetical protein LOC152405 [Homo sapiens] 37 0.030
gi|28882049 replication factor C 2 isoform 2 [Homo sapiens] 37 0.040
gi|31563534 replication factor C 2 isoform 1 [Homo sapiens] 35 0.12
gi|38570064 hypothetical protein LOC136895 [Homo sapiens] 33 0.75
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 32 0.97
gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens] 32 1.3
gi|119703749 hydrocephalus inducing isoform a [Homo sapiens] 31 2.2
gi|24307899 Era-like 1 [Homo sapiens] 31 2.2
gi|39753961 IQ motif containing GTPase activating protein 3 [Hom... 31 2.8
gi|4505725 peroxin1 [Homo sapiens] 30 3.7
gi|57634534 nucleoporin 205kDa [Homo sapiens] 30 3.7
gi|4506787 IQ motif containing GTPase activating protein 1 [Homo... 30 4.8
gi|197276594 RNA binding motif protein 20 [Homo sapiens] 30 4.8
gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens] 30 6.3
gi|145699133 KPL2 protein isoform 1 [Homo sapiens] 30 6.3
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 30 6.3
>gi|22749187 putative adenylate kinase-like protein C9orf98 [Homo
sapiens]
Length = 479
Score = 967 bits (2500), Expect = 0.0
Identities = 479/479 (100%), Positives = 479/479 (100%)
Query: 1 MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRI 60
MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRI
Sbjct: 1 MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRI 60
Query: 61 VILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQ 120
VILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQ
Sbjct: 61 VILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQ 120
Query: 121 LIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRI 180
LIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRI
Sbjct: 121 LIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRI 180
Query: 181 DPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVI 240
DPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVI
Sbjct: 181 DPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVI 240
Query: 241 SADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCG 300
SADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCG
Sbjct: 241 SADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCG 300
Query: 301 QLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLD 360
QLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLD
Sbjct: 301 QLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLD 360
Query: 361 QAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQ 420
QAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQ
Sbjct: 361 QAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQ 420
Query: 421 NPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP 479
NPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
Sbjct: 421 NPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP 479
>gi|53832001 adenylate kinase 3-like 1 isoform 7 [Homo sapiens]
Length = 223
Score = 92.4 bits (228), Expect = 8e-19
Identities = 56/184 (30%), Positives = 97/184 (52%), Gaps = 7/184 (3%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R ++LGP GSGK +AQ + L ++ G L+E + T GE+ + + EK + VPD
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPD 66
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERL 389
++ +++ L+ + + W+L G PR L QA L+++ + V LN+PF+++ +RL
Sbjct: 67 HVITRLMMSELENRR--GQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLKDRL 123
Query: 390 TLRRIDPVTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNSADLEQ 445
+ R I P +G Y+L + PP I L+Q D E V ++ + + + +
Sbjct: 124 SRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIE 183
Query: 446 LYGS 449
LY S
Sbjct: 184 LYKS 187
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/182 (26%), Positives = 86/182 (47%), Gaps = 17/182 (9%)
Query: 59 RIVILGPPASGKTTIAMWLC-----KHLNSSLLTLENLILNEFSYTATEARRLYLQRK-T 112
R VILGPP SGK T+ + +HL+S EN+ + S E + Y+++
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENI---KASTEVGEMAKQYIEKSLL 63
Query: 113 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLI 172
VP ++ +L+ L E+ Q W+LDG P T QA + + VI L+ P L
Sbjct: 64 VPDHVITRLMMSEL--ENRRGQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLK 120
Query: 173 ERNLGKRIDPQTGEIYHTTFDWPPE----SEIQNRLMVPEDISELETAQKLLEYHRNIVR 228
+R + I P +G +Y+ F+ PP ++ +V ++ + E L ++++ +
Sbjct: 121 DRLSRRWIHPPSGRVYNLDFN-PPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAK 179
Query: 229 VI 230
+
Sbjct: 180 PV 181
>gi|53832003 adenylate kinase 3-like 1 isoform 5 [Homo sapiens]
Length = 223
Score = 92.4 bits (228), Expect = 8e-19
Identities = 56/184 (30%), Positives = 97/184 (52%), Gaps = 7/184 (3%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R ++LGP GSGK +AQ + L ++ G L+E + T GE+ + + EK + VPD
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPD 66
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERL 389
++ +++ L+ + + W+L G PR L QA L+++ + V LN+PF+++ +RL
Sbjct: 67 HVITRLMMSELENRR--GQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLKDRL 123
Query: 390 TLRRIDPVTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNSADLEQ 445
+ R I P +G Y+L + PP I L+Q D E V ++ + + + +
Sbjct: 124 SRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIE 183
Query: 446 LYGS 449
LY S
Sbjct: 184 LYKS 187
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/182 (26%), Positives = 86/182 (47%), Gaps = 17/182 (9%)
Query: 59 RIVILGPPASGKTTIAMWLC-----KHLNSSLLTLENLILNEFSYTATEARRLYLQRK-T 112
R VILGPP SGK T+ + +HL+S EN+ + S E + Y+++
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENI---KASTEVGEMAKQYIEKSLL 63
Query: 113 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLI 172
VP ++ +L+ L E+ Q W+LDG P T QA + + VI L+ P L
Sbjct: 64 VPDHVITRLMMSEL--ENRRGQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLK 120
Query: 173 ERNLGKRIDPQTGEIYHTTFDWPPE----SEIQNRLMVPEDISELETAQKLLEYHRNIVR 228
+R + I P +G +Y+ F+ PP ++ +V ++ + E L ++++ +
Sbjct: 121 DRLSRRWIHPPSGRVYNLDFN-PPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAK 179
Query: 229 VI 230
+
Sbjct: 180 PV 181
>gi|8051579 adenylate kinase 3-like 1 isoform 6 [Homo sapiens]
Length = 223
Score = 92.4 bits (228), Expect = 8e-19
Identities = 56/184 (30%), Positives = 97/184 (52%), Gaps = 7/184 (3%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R ++LGP GSGK +AQ + L ++ G L+E + T GE+ + + EK + VPD
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPD 66
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERL 389
++ +++ L+ + + W+L G PR L QA L+++ + V LN+PF+++ +RL
Sbjct: 67 HVITRLMMSELENRR--GQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLKDRL 123
Query: 390 TLRRIDPVTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNSADLEQ 445
+ R I P +G Y+L + PP I L+Q D E V ++ + + + +
Sbjct: 124 SRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIE 183
Query: 446 LYGS 449
LY S
Sbjct: 184 LYKS 187
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/182 (26%), Positives = 86/182 (47%), Gaps = 17/182 (9%)
Query: 59 RIVILGPPASGKTTIAMWLC-----KHLNSSLLTLENLILNEFSYTATEARRLYLQRK-T 112
R VILGPP SGK T+ + +HL+S EN+ + S E + Y+++
Sbjct: 7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENI---KASTEVGEMAKQYIEKSLL 63
Query: 113 VPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLI 172
VP ++ +L+ L E+ Q W+LDG P T QA + + VI L+ P L
Sbjct: 64 VPDHVITRLMMSEL--ENRRGQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLK 120
Query: 173 ERNLGKRIDPQTGEIYHTTFDWPPE----SEIQNRLMVPEDISELETAQKLLEYHRNIVR 228
+R + I P +G +Y+ F+ PP ++ +V ++ + E L ++++ +
Sbjct: 121 DRLSRRWIHPPSGRVYNLDFN-PPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAK 179
Query: 229 VI 230
+
Sbjct: 180 PV 181
>gi|19923437 adenylate kinase 3 [Homo sapiens]
Length = 227
Score = 89.0 bits (219), Expect = 9e-18
Identities = 59/215 (27%), Positives = 108/215 (50%), Gaps = 11/215 (5%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R +++G GSGK ++ + + L ++ G LL++ + T G L + F ++ +PD
Sbjct: 9 RAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPD 68
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERL 389
++ ++ L ++ Q W+L G PR L QA L+R Y + V LNVPF+ I +RL
Sbjct: 69 DVMTRLALHEL--KNLTQYSWLLDGFPRTLPQAEALDR-AYQIDTVINLNVPFEVIKQRL 125
Query: 390 TLRRIDPVTGERYHLMYKPPPTMEIQ----ARLLQNPKDAEEQVKLKMDLFYRNSADLEQ 445
T R I P +G Y++ + PP T+ I L+Q D E V ++ + + + +
Sbjct: 126 TARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKPVLE 185
Query: 446 LY---GSAITLNGDQDPYTVFEYIESGIINPLPKK 477
Y G T +G + ++ Y+ + + +P++
Sbjct: 186 YYQKKGVLETFSG-TETNKIWPYVYAFLQTKVPQR 219
Score = 56.2 bits (134), Expect = 6e-08
Identities = 47/184 (25%), Positives = 87/184 (47%), Gaps = 15/184 (8%)
Query: 59 RIVILGPPASGKTTIAMWL-----CKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTV 113
R VI+G P SGK T++ + KHL+S L +N++ + A+ Q K +
Sbjct: 9 RAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRG--TEIGVLAKAFIDQGKLI 66
Query: 114 PSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIE 173
P ++ +L L ++ + W+LDG P T QA + VI L+ P V+ +
Sbjct: 67 PDDVMTRLALHEL--KNLTQYSWLLDGFPRTLPQAEALDR-AYQIDTVINLNVPFEVIKQ 123
Query: 174 RNLGKRIDPQTGEIYHTTFDWPPES----EIQNRLMVPEDISELETAQKLLEYHRNIVRV 229
R + I P +G +Y+ F+ PP++ ++ ++ + + ET K L+ + + +
Sbjct: 124 RLTARWIHPASGRVYNIEFN-PPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQTKP 182
Query: 230 IPSY 233
+ Y
Sbjct: 183 VLEY 186
>gi|4502013 adenylate kinase 2 isoform a [Homo sapiens]
Length = 239
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/208 (26%), Positives = 105/208 (50%), Gaps = 12/208 (5%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R +LLGP G+GK QA LA+ + + ++ G +L+ VA + G+ ++ + V D
Sbjct: 17 RAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSD 76
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSI 385
++++++ + L+ C + G++L G PR + QA +L+ L + V ++P +
Sbjct: 77 EMVVELIEKNLETPLC-KNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLL 135
Query: 386 MERLTLRRIDPVTGERYHLMYKPP--PTME--IQARLLQNPKDAEEQVKLKMDLFYRNSA 441
+ R+T R I P +G YH + PP P + L++ D E+ +K+++ ++ +
Sbjct: 136 IRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTT 195
Query: 442 DLEQLY---GSAITLNGDQDPYTVFEYI 466
L + Y G ++ Q P VF I
Sbjct: 196 PLIEYYRKRGIHSAIDASQTPDVVFASI 223
Score = 67.0 bits (162), Expect = 4e-11
Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 59 RIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQR---KTVPS 115
R V+LGPP +GK T A L ++ L +++ + + ++L K V
Sbjct: 17 RAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSD 76
Query: 116 ALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRH----VIVLSAPDTVL 171
++V+LI++ L C K G++LDG P T QA + L + VI S PD++L
Sbjct: 77 EMVVELIEKNLETPLC-KNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLL 135
Query: 172 IERNLGKRIDPQTGEIYHTTFDWPPESEIQN-----RLMVPEDISELETAQKLLEYHRNI 226
I R G+ I P++G YH F+ PP+ +++ L+ D +E +L YH
Sbjct: 136 IRRITGRLIHPKSGRSYHEEFN-PPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQT 194
Query: 227 VRVIPSYPK--ILKVISADQPCVDVFYQAL 254
+I Y K I I A Q VF L
Sbjct: 195 TPLIEYYRKRGIHSAIDASQTPDVVFASIL 224
>gi|7524346 adenylate kinase 2 isoform b [Homo sapiens]
Length = 232
Score = 81.6 bits (200), Expect = 1e-15
Identities = 55/208 (26%), Positives = 105/208 (50%), Gaps = 12/208 (5%)
Query: 270 RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPD 329
R +LLGP G+GK QA LA+ + + ++ G +L+ VA + G+ ++ + V D
Sbjct: 17 RAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSD 76
Query: 330 SLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRL----GYNPNRVFFLNVPFDSI 385
++++++ + L+ C + G++L G PR + QA +L+ L + V ++P +
Sbjct: 77 EMVVELIEKNLETPLC-KNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLL 135
Query: 386 MERLTLRRIDPVTGERYHLMYKPP--PTME--IQARLLQNPKDAEEQVKLKMDLFYRNSA 441
+ R+T R I P +G YH + PP P + L++ D E+ +K+++ ++ +
Sbjct: 136 IRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTT 195
Query: 442 DLEQLY---GSAITLNGDQDPYTVFEYI 466
L + Y G ++ Q P VF I
Sbjct: 196 PLIEYYRKRGIHSAIDASQTPDVVFASI 223
Score = 67.0 bits (162), Expect = 4e-11
Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 16/210 (7%)
Query: 59 RIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQR---KTVPS 115
R V+LGPP +GK T A L ++ L +++ + + ++L K V
Sbjct: 17 RAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSD 76
Query: 116 ALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRH----VIVLSAPDTVL 171
++V+LI++ L C K G++LDG P T QA + L + VI S PD++L
Sbjct: 77 EMVVELIEKNLETPLC-KNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLL 135
Query: 172 IERNLGKRIDPQTGEIYHTTFDWPPESEIQN-----RLMVPEDISELETAQKLLEYHRNI 226
I R G+ I P++G YH F+ PP+ +++ L+ D +E +L YH
Sbjct: 136 IRRITGRLIHPKSGRSYHEEFN-PPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQT 194
Query: 227 VRVIPSYPK--ILKVISADQPCVDVFYQAL 254
+I Y K I I A Q VF L
Sbjct: 195 TPLIEYYRKRGIHSAIDASQTPDVVFASIL 224
>gi|28144897 adenylate kinase 5 isoform 1 [Homo sapiens]
Length = 562
Score = 68.2 bits (165), Expect = 2e-11
Identities = 76/390 (19%), Positives = 157/390 (40%), Gaps = 81/390 (20%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEAR-----RLYLQRKTVP 114
I+++G P SGK T ++ + + +++ L+ + T++ + ++ + P
Sbjct: 135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAP 194
Query: 115 SALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIER 174
+ I+++L + ++G ++DG P QAL + TP V+ L+ + L ER
Sbjct: 195 QETTITEIKQKLMQIPD-EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKER 253
Query: 175 NLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYP 234
L + +E Q R P+D + T ++L+ + +N ++ +
Sbjct: 254 LLKR-------------------AEQQGR---PDD-NVKATQRRLMNFKQNAAPLVKYFQ 290
Query: 235 K--ILKVISADQPCVDVFYQALTYVQSNHRTN-------APFTPRVLL------------ 273
+ ++ AD+ +VFY V + N + P ++L
Sbjct: 291 EKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDY 350
Query: 274 -------------------------------LGPVGSGKSLQAALLAQKYRLVNVCCGQL 302
+G GSGK Q L +KY ++ G+L
Sbjct: 351 EDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGEL 410
Query: 303 LKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQA 362
L+E +A + +LI+ E+ VP +++++L + + +G+++ G PR++ Q
Sbjct: 411 LREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQG 470
Query: 363 HLLNRLGYNPNRVFFLNVPFDSIMERLTLR 392
R +P V ++ D++ RL R
Sbjct: 471 EEFGRRIGDPQLVICMDCSADTMTNRLLQR 500
Score = 50.1 bits (118), Expect = 5e-06
Identities = 55/217 (25%), Positives = 91/217 (41%), Gaps = 32/217 (14%)
Query: 266 PFTPR---VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGE--LIQPF 320
P PR +L++G GSGK Q+ +A++Y + G+LL++ + ++ + LI
Sbjct: 127 PTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKI 186
Query: 321 FEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNV 380
P + + Q+L Q ++G V+ G PRD+ QA P+ V FL
Sbjct: 187 ITTGELAPQETTITEIKQKL-MQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLAC 245
Query: 381 PFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNS 440
+ ERL R E Q R P D + + ++ F +N+
Sbjct: 246 ANQRLKERLLKR-------------------AEQQGR----PDDNVKATQRRLMNFKQNA 282
Query: 441 ADLEQLY---GSAITLNGDQDPYTVFEYIESGIINPL 474
A L + + G +T + D+D VF I + N L
Sbjct: 283 APLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKL 319
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 38/210 (18%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKT------V 113
I I+G P SGK T L + + L+ L+ E A+E+ R L R V
Sbjct: 379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREEL---ASESERSKLIRDIMERGDLV 435
Query: 114 PSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIE 173
PS ++++L++E + +G+++DG P +Q
Sbjct: 436 PSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQG------------------------- 470
Query: 174 RNLGKRI-DPQTGEIYHTTFDWPPESEIQ-NRLMVPEDISELETAQKLLEYHRNIVRVIP 231
G+RI DPQ + D +Q +R +P D + A++L Y+R + VI
Sbjct: 471 EEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIA 530
Query: 232 SY--PKILKVISADQPCVDVFYQALTYVQS 259
Y L I+A+ DVF Q T + S
Sbjct: 531 YYETKTQLHKINAEGTPEDVFLQLCTAIDS 560
>gi|28144899 adenylate kinase 5 isoform 2 [Homo sapiens]
Length = 536
Score = 68.2 bits (165), Expect = 2e-11
Identities = 76/390 (19%), Positives = 157/390 (40%), Gaps = 81/390 (20%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEAR-----RLYLQRKTVP 114
I+++G P SGK T ++ + + +++ L+ + T++ + ++ + P
Sbjct: 109 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAP 168
Query: 115 SALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIER 174
+ I+++L + ++G ++DG P QAL + TP V+ L+ + L ER
Sbjct: 169 QETTITEIKQKLMQIPD-EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKER 227
Query: 175 NLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYP 234
L + +E Q R P+D + T ++L+ + +N ++ +
Sbjct: 228 LLKR-------------------AEQQGR---PDD-NVKATQRRLMNFKQNAAPLVKYFQ 264
Query: 235 K--ILKVISADQPCVDVFYQALTYVQSNHRTN-------APFTPRVLL------------ 273
+ ++ AD+ +VFY V + N + P ++L
Sbjct: 265 EKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDY 324
Query: 274 -------------------------------LGPVGSGKSLQAALLAQKYRLVNVCCGQL 302
+G GSGK Q L +KY ++ G+L
Sbjct: 325 EDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGEL 384
Query: 303 LKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQA 362
L+E +A + +LI+ E+ VP +++++L + + +G+++ G PR++ Q
Sbjct: 385 LREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQG 444
Query: 363 HLLNRLGYNPNRVFFLNVPFDSIMERLTLR 392
R +P V ++ D++ RL R
Sbjct: 445 EEFGRRIGDPQLVICMDCSADTMTNRLLQR 474
Score = 50.1 bits (118), Expect = 5e-06
Identities = 55/217 (25%), Positives = 91/217 (41%), Gaps = 32/217 (14%)
Query: 266 PFTPR---VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGE--LIQPF 320
P PR +L++G GSGK Q+ +A++Y + G+LL++ + ++ + LI
Sbjct: 101 PTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKI 160
Query: 321 FEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNV 380
P + + Q+L Q ++G V+ G PRD+ QA P+ V FL
Sbjct: 161 ITTGELAPQETTITEIKQKL-MQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLAC 219
Query: 381 PFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNS 440
+ ERL R E Q R P D + + ++ F +N+
Sbjct: 220 ANQRLKERLLKR-------------------AEQQGR----PDDNVKATQRRLMNFKQNA 256
Query: 441 ADLEQLY---GSAITLNGDQDPYTVFEYIESGIINPL 474
A L + + G +T + D+D VF I + N L
Sbjct: 257 APLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKL 293
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 38/210 (18%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKT------V 113
I I+G P SGK T L + + L+ L+ E A+E+ R L R V
Sbjct: 353 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREEL---ASESERSKLIRDIMERGDLV 409
Query: 114 PSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIE 173
PS ++++L++E + +G+++DG P +Q
Sbjct: 410 PSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQG------------------------- 444
Query: 174 RNLGKRI-DPQTGEIYHTTFDWPPESEIQ-NRLMVPEDISELETAQKLLEYHRNIVRVIP 231
G+RI DPQ + D +Q +R +P D + A++L Y+R + VI
Sbjct: 445 EEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIA 504
Query: 232 SY--PKILKVISADQPCVDVFYQALTYVQS 259
Y L I+A+ DVF Q T + S
Sbjct: 505 YYETKTQLHKINAEGTPEDVFLQLCTAIDS 534
>gi|237858799 adenylate kinase domain containing 1 isoform 1 [Homo
sapiens]
Length = 1911
Score = 56.6 bits (135), Expect = 5e-08
Identities = 43/150 (28%), Positives = 70/150 (46%), Gaps = 8/150 (5%)
Query: 40 EDPIPFMIQHLHRDNDNVP-RIVILGPPASGKTTIAMWLCKHLNSSLLTLENL---ILNE 95
++PI ++ Q + VP RI+I+GPP SGKTT+A + L++ +LN
Sbjct: 1395 KNPIKYIRQP--KPKPTVPIRIIIVGPPKSGKTTVAKKITSEYGLKHLSIGGALRYVLNN 1452
Query: 96 FSYTATEARRLYLQRK--TVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQT 153
T + K T P L +Q ++ L E C G ++DG P T+ Q ++
Sbjct: 1453 HPETELALMLNWHLHKGMTAPDELAIQALELSLMESVCNTAGVVIDGYPVTKHQMNLLEA 1512
Query: 154 LGITPRHVIVLSAPDTVLIERNLGKRIDPQ 183
I P + LS P + +R L ++ + Q
Sbjct: 1513 RSIIPMVIFELSVPSKEIFKRLLLEKENEQ 1542
Score = 56.2 bits (134), Expect = 6e-08
Identities = 45/177 (25%), Positives = 73/177 (41%), Gaps = 19/177 (10%)
Query: 236 ILKVISADQPCVDVFYQALTYVQSNHRTNAPFTP-----------------RVLLLGPVG 278
I V +A+ P V ++ Y S+ T F R++++GP
Sbjct: 1362 IKPVENAENPIYPVIHRQYIYFLSSKETKEKFMKNPIKYIRQPKPKPTVPIRIIIVGPPK 1421
Query: 279 SGKSLQAALLAQKYRLVNVCCGQLLKEAVADR--TTFGELIQPFFEKEMAVPDSLLMKVL 336
SGK+ A + +Y L ++ G L+ + + T ++ K M PD L ++ L
Sbjct: 1422 SGKTTVAKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNWHLHKGMTAPDELAIQAL 1481
Query: 337 SQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRR 393
L + C G V+ G P Q +LL P +F L+VP I +RL L +
Sbjct: 1482 ELSLMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLLLEK 1538
Score = 55.1 bits (131), Expect = 1e-07
Identities = 42/149 (28%), Positives = 71/149 (47%), Gaps = 15/149 (10%)
Query: 61 VILGPPASGKTTIAM-----WLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPS 115
V+ G P GKTT+A W C + + L LE I E + + + + + +++P
Sbjct: 34 VVFGKPGVGKTTLARYITQAWKCIRVEA-LPILEEQIAAE-TESGVMLQSMLISGQSIPD 91
Query: 116 ALLVQLIQERLAEEDCIKQGWILDGIPETREQALR-------IQTLGITPRHVIVLSAPD 168
L+++L+ E+L + G+I+ IP + A+ I+ L + P +I + PD
Sbjct: 92 ELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDAMTTLQQIELIKNLNLKPDVIINIKCPD 151
Query: 169 TVLIERNLGKRIDPQTGEIYHTTFDWPPE 197
L +R G+R TG IY + W PE
Sbjct: 152 YDLCQRISGQRQHNNTGYIY-SRDQWDPE 179
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/178 (21%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 243 DQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQL 302
+ P D+F + T + N + P ++ G G GK+ A + Q ++ + V +
Sbjct: 9 EYPFADIFDEDET--ERNFLLSKPVC--FVVFGKPGVGKTTLARYITQAWKCIRVEALPI 64
Query: 303 LKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVP------ 356
L+E +A T G ++Q ++PD L++K++ ++L+ + G+++ +P
Sbjct: 65 LEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDA 124
Query: 357 -RDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTME 413
L Q L+ L P+ + + P + +R++ +R TG Y P +E
Sbjct: 125 MTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIE 182
Score = 41.6 bits (96), Expect = 0.002
Identities = 63/284 (22%), Positives = 107/284 (37%), Gaps = 78/284 (27%)
Query: 184 TGEIYHT-TFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISA 242
TGE Y T D+ E+E+ L E+ E E K+ E R++ P +LK
Sbjct: 889 TGEDYEEETEDYQTEAEVDEEL---EEEEEEEGEDKMKERKRHLGDTKHFCPVVLKENFI 945
Query: 243 DQPC---------VDVFYQALT------------YVQSNHRTNAPFTPRVLLLGPVGSGK 281
QP ++Y + YV AP R+ L+GP GSGK
Sbjct: 946 LQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEEPLKAP-PLRICLVGPQGSGK 1004
Query: 282 SLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEK-------------EMAV- 327
++ LA+K + ++ ++L+E + +T + + P FE+ E+A+
Sbjct: 1005 TMCGRQLAEKLNIFHIQFEEVLQEKLLLKTE--KKVGPEFEEDSENEQAAKQELEELAIQ 1062
Query: 328 ------------------------------------PDSLLMKVLSQRLDQQDCIQKGWV 351
P +L +LS+ ++ G++
Sbjct: 1063 ANVKVEEENTKKQLPEVQLTEEEEVIKSSLMENEPLPPEILEVILSEWWLKEPIRSTGFI 1122
Query: 352 LHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRID 395
L G PR ++A L G+ P+ F+ V I +RL +I+
Sbjct: 1123 LDGFPRYPEEAQFLGDRGFFPDAAVFIQVDDQDIFDRLLPAQIE 1166
Score = 33.1 bits (74), Expect = 0.57
Identities = 18/74 (24%), Positives = 35/74 (47%)
Query: 108 LQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAP 167
++ + +P +L ++ E +E G+ILDG P E+A + G P + +
Sbjct: 1093 MENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFPDAAVFIQVD 1152
Query: 168 DTVLIERNLGKRID 181
D + +R L +I+
Sbjct: 1153 DQDIFDRLLPAQIE 1166
Score = 30.4 bits (67), Expect = 3.7
Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 5/72 (6%)
Query: 59 RIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTV-PSAL 117
++ ILGP SGKTT+ L ++ ++ L+ F +AR ++ +A
Sbjct: 393 KVFILGPQYSGKTTLCNMLAENYKGKVVDYAQLVQPRFD----KARETLVENTIAEATAA 448
Query: 118 LVQLIQERLAEE 129
+++++E+L E
Sbjct: 449 AIKVVKEKLLRE 460
>gi|4502011 adenylate kinase 1 [Homo sapiens]
Length = 194
Score = 55.1 bits (131), Expect = 1e-07
Identities = 31/125 (24%), Positives = 60/125 (48%)
Query: 268 TPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAV 327
T + ++G GSGK Q + QKY ++ G LL+ V+ + G+ + EK V
Sbjct: 8 TKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLV 67
Query: 328 PDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIME 387
P ++ +L + + KG+++ G PR++ Q R P + +++ +++ +
Sbjct: 68 PLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQ 127
Query: 388 RLTLR 392
RL R
Sbjct: 128 RLLKR 132
Score = 35.0 bits (79), Expect = 0.15
Identities = 43/206 (20%), Positives = 90/206 (43%), Gaps = 30/206 (14%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRL---YLQRKTVPSA 116
I ++G P SGK T + + + L+ +L+ +E S + ++L + + VP
Sbjct: 11 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLE 70
Query: 117 LLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNL 176
++ ++++ + + +G+++DG P +Q + P ++ + A + +R L
Sbjct: 71 TVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLL 130
Query: 177 GKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLE-YHRNIVRVIPSYPK 235
+ E R+ D +E ET +K LE Y++ VI Y K
Sbjct: 131 KR-------------------GETSGRV----DDNE-ETIKKRLETYYKATEPVIAFYEK 166
Query: 236 --ILKVISADQPCVDVFYQALTYVQS 259
I++ ++A+ VF Q T++ +
Sbjct: 167 RGIVRKVNAEGSVDSVFSQVCTHLDA 192
>gi|21450759 adenylate kinase domain containing 1 isoform 2 [Homo
sapiens]
Length = 421
Score = 55.1 bits (131), Expect = 1e-07
Identities = 42/149 (28%), Positives = 71/149 (47%), Gaps = 15/149 (10%)
Query: 61 VILGPPASGKTTIAM-----WLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPS 115
V+ G P GKTT+A W C + + L LE I E + + + + + +++P
Sbjct: 34 VVFGKPGVGKTTLARYITQAWKCIRVEA-LPILEEQIAAE-TESGVMLQSMLISGQSIPD 91
Query: 116 ALLVQLIQERLAEEDCIKQGWILDGIPETREQALR-------IQTLGITPRHVIVLSAPD 168
L+++L+ E+L + G+I+ IP + A+ I+ L + P +I + PD
Sbjct: 92 ELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDAMTTLQQIELIKNLNLKPDVIINIKCPD 151
Query: 169 TVLIERNLGKRIDPQTGEIYHTTFDWPPE 197
L +R G+R TG IY + W PE
Sbjct: 152 YDLCQRISGQRQHNNTGYIY-SRDQWDPE 179
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/178 (21%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 243 DQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQL 302
+ P D+F + T + N + P ++ G G GK+ A + Q ++ + V +
Sbjct: 9 EYPFADIFDEDET--ERNFLLSKPVC--FVVFGKPGVGKTTLARYITQAWKCIRVEALPI 64
Query: 303 LKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVP------ 356
L+E +A T G ++Q ++PD L++K++ ++L+ + G+++ +P
Sbjct: 65 LEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITEIPSLSQDA 124
Query: 357 -RDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTME 413
L Q L+ L P+ + + P + +R++ +R TG Y P +E
Sbjct: 125 MTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEVIE 182
>gi|7706497 UMP-CMP kinase 1 isoform a [Homo sapiens]
Length = 228
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 271 VLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLK-EAVADRTTFGELIQPFFEKEMAVPD 329
V +LG G+GK Q A + +KY ++ G+LL+ E + +GELI+ + ++ VP
Sbjct: 38 VFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPV 97
Query: 330 SLLMKVLSQRLDQ---QDCIQKGWVLHGVPRDLDQAHLLNR 367
+ + +L + +DQ + + +++ G PR+ D N+
Sbjct: 98 EITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNK 138
>gi|148727333 adenylate kinase 7 [Homo sapiens]
Length = 723
Score = 37.7 bits (86), Expect = 0.023
Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 32/122 (26%)
Query: 59 RIVILGPPASGKTTIAMWLCKH-----------LNSSLLTLENLIL-------------N 94
+I ILGPPA GK++IA L + ++ ++ LE ++
Sbjct: 369 KICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEE 428
Query: 95 EFSYTATEARRLYLQRKT--------VPSALLVQLIQERLAEEDCIKQGWILDGIPETRE 146
E +A+ L K + +++ ++E+L C QG+ILDG P+T +
Sbjct: 429 EEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYD 488
Query: 147 QA 148
QA
Sbjct: 489 QA 490
Score = 36.2 bits (82), Expect = 0.068
Identities = 30/143 (20%), Positives = 58/143 (40%), Gaps = 30/143 (20%)
Query: 250 FYQALTYVQSNHRTNAPFTP-RVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVA 308
F + + + ++ + P ++ +LGP GKS A LA Y+L ++ ++ EA+A
Sbjct: 348 FVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIA 407
Query: 309 DRTTF------GELIQPFFEKEMA-----------------------VPDSLLMKVLSQR 339
GE + E+E + D +++ + ++
Sbjct: 408 KLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEK 467
Query: 340 LDQQDCIQKGWVLHGVPRDLDQA 362
L C +G++L G P+ DQA
Sbjct: 468 LKSMPCRNQGYILDGFPKTYDQA 490
>gi|22749117 hypothetical protein LOC152405 [Homo sapiens]
Length = 536
Score = 37.4 bits (85), Expect = 0.030
Identities = 14/32 (43%), Positives = 23/32 (71%)
Query: 16 QYGEENHIFELMQNMLEQLLIHQPEDPIPFMI 47
QY E++HI ++ Q + E L+ +PEDP+ FM+
Sbjct: 502 QYMEKHHILQIFQQITENLVYEKPEDPLNFML 533
>gi|28882049 replication factor C 2 isoform 2 [Homo sapiens]
Length = 320
Score = 37.0 bits (84), Expect = 0.040
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 56 NVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQR 110
NVP I+I GPP +GKTT + L + L L L LN + + T+ + L+R
Sbjct: 68 NVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDSMTDGAQQALRR 122
>gi|31563534 replication factor C 2 isoform 1 [Homo sapiens]
Length = 354
Score = 35.4 bits (80), Expect = 0.12
Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 56 NVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARR----LYLQRK 111
NVP I+I GPP +GKTT + L + L L L LN + + R ++ Q+K
Sbjct: 68 NVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQK 127
Query: 112 -TVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALR--IQTLGITPRHVIVLSAPD 168
T+P +I L E D + G +QALR ++ T R + +A D
Sbjct: 128 VTLPKGRHKIII---LDEADSMTDG---------AQQALRRTMEIYSKTTRFALACNASD 175
Query: 169 TVL 171
++
Sbjct: 176 KII 178
>gi|38570064 hypothetical protein LOC136895 [Homo sapiens]
Length = 590
Score = 32.7 bits (73), Expect = 0.75
Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 355 VPRDLDQAHLLNRL-----GYNPNRVFFLNVPFDSIMERLTLR-RIDPVTGERYHLMYKP 408
+ R+L+++H L G P L+ + ++ LT + DP E++H ++KP
Sbjct: 268 IQRNLERSHWLTSYTHDFTGLGPMDPLELDDYHEKMVAELTRKIGFDPEPQEKFHPVFKP 327
Query: 409 PPTMEIQ-ARLLQNPKDAEEQVK 430
P +E + ARL+QN + E V+
Sbjct: 328 PRPLEGRIARLIQNRRSLEAIVQ 350
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 32.3 bits (72), Expect = 0.97
Identities = 34/171 (19%), Positives = 73/171 (42%), Gaps = 15/171 (8%)
Query: 304 KEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAH 363
+E D TF + + E E + L ++ + LD+ +C+ K + V +L
Sbjct: 680 QEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCK--LSSSVKTNLG--- 734
Query: 364 LLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPK 423
+ ++ R+F L +E T R I+ V + + PT++I R+ +
Sbjct: 735 -VGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKI--RVASKKE 791
Query: 424 DAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPL 474
E +K + DL++ +++++ + +DP+ Y++ + N L
Sbjct: 792 VFEANLKTECDLWH---LMVKEMWAGKKLADDHKDPH----YVQQALTNVL 835
>gi|194018488 peroxisomal biogenesis factor 6 [Homo sapiens]
Length = 980
Score = 32.0 bits (71), Expect = 1.3
Identities = 18/66 (27%), Positives = 33/66 (50%), Gaps = 3/66 (4%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTL--ENLILNEFSYTATEARRLYLQ-RKTVPSA 116
+++ GPP GKTT+ C HL LL + +L T+ + ++ + R+ P+
Sbjct: 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAV 525
Query: 117 LLVQLI 122
LL+ +
Sbjct: 526 LLLTAV 531
>gi|119703749 hydrocephalus inducing isoform a [Homo sapiens]
Length = 5120
Score = 31.2 bits (69), Expect = 2.2
Identities = 24/87 (27%), Positives = 45/87 (51%), Gaps = 12/87 (13%)
Query: 60 IVILGPPASGKTTIAMWLCKHLNSSLLTLENLIL----NEFSYTATEARRLYLQRKTVPS 115
I+I G P SGK+ A+ + K+ N++ L++++++L N + AR L ++
Sbjct: 2038 IIIHGTPLSGKSANAVSVAKYYNAACLSIDSIVLEAVANSNNIPGIRARELCIR------ 2091
Query: 116 ALLVQLIQ--ERLAEEDCIKQGWILDG 140
A + Q ++ E A+E + Q I G
Sbjct: 2092 AAIEQSVKEGEEAAQEAAVGQNVIGQG 2118
>gi|24307899 Era-like 1 [Homo sapiens]
Length = 437
Score = 31.2 bits (69), Expect = 2.2
Identities = 15/41 (36%), Positives = 24/41 (58%), Gaps = 10/41 (24%)
Query: 34 LLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIA 74
LL+H P+ P +N V R+V+LG P +GK+T++
Sbjct: 100 LLVHHPDMP----------ENSRVLRVVLLGAPNAGKSTLS 130
>gi|39753961 IQ motif containing GTPase activating protein 3 [Homo
sapiens]
Length = 1631
Score = 30.8 bits (68), Expect = 2.8
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 11/89 (12%)
Query: 391 LRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSA 450
+ + + TG+R HL Y P + + +V+ ++D+ RN + + A
Sbjct: 1083 INQTEAQTGQRSHLPYDVTPEQAL----------SHPEVQRRLDIALRNLLAMTDKFLLA 1132
Query: 451 ITLNGDQDPYTVFEYIESGIINPLPKKIP 479
IT + DQ PY + Y+ + L +K P
Sbjct: 1133 ITSSVDQIPYGM-RYVAKVLKATLAEKFP 1160
>gi|4505725 peroxin1 [Homo sapiens]
Length = 1283
Score = 30.4 bits (67), Expect = 3.7
Identities = 45/158 (28%), Positives = 76/158 (48%), Gaps = 37/158 (23%)
Query: 264 NAPFTPR--VLLLGPVGSGKSLQAALLAQKYRL--VNVCCGQLL-------KEAVADRTT 312
N P R +LL GP G+GK+L A ++A++ R+ ++V +LL ++AV D
Sbjct: 868 NLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFI 927
Query: 313 FGELIQP---FFEK-----------EMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRD 358
+ +P FF++ V D ++ ++L+Q LD + +Q +VL R
Sbjct: 928 RAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQ-LDGVEGLQGVYVLAATSRP 986
Query: 359 --LDQAHL----LNRLGYNP-----NRVFFLNVPFDSI 385
+D A L L++ Y P +R+ LNV DS+
Sbjct: 987 DLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSL 1024
>gi|57634534 nucleoporin 205kDa [Homo sapiens]
Length = 2012
Score = 30.4 bits (67), Expect = 3.7
Identities = 18/64 (28%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 196 PESEIQN--RLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVIS-ADQPCVDVFYQ 252
P EI+ + ++P + ++ TAQK + R +V+VI + K+L + S + C+ + ++
Sbjct: 1847 PPDEIKELCQSVMPAGVDKISTAQKYVLARRRLVKVINNRAKLLSLCSFIIETCLFILWR 1906
Query: 253 ALTY 256
L Y
Sbjct: 1907 HLEY 1910
>gi|4506787 IQ motif containing GTPase activating protein 1 [Homo
sapiens]
Length = 1657
Score = 30.0 bits (66), Expect = 4.8
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
Query: 378 LNVPFDSI-MERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLF 436
LN+ D + + + + +++ TGE L Y P + A E+VK ++D
Sbjct: 1085 LNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQAL----------AHEEVKTRLDSS 1134
Query: 437 YRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP 479
RN + + SAI + D+ PY + +I + + L +K P
Sbjct: 1135 IRNMRAVTDKFLSAIVSSVDKIPYGM-RFIAKVLKDSLHEKFP 1176
>gi|197276594 RNA binding motif protein 20 [Homo sapiens]
Length = 1227
Score = 30.0 bits (66), Expect = 4.8
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)
Query: 193 DWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQ 244
DW ESE + P ++ EL T ++ E IV P P++ +++ DQ
Sbjct: 888 DWESESEAEGESWYPTNMEELVTVDEVGEEEDFIVE--PDIPELEEIVPIDQ 937
>gi|222144249 dynein heavy chain domain 1 isoform 1 [Homo sapiens]
Length = 4753
Score = 29.6 bits (65), Expect = 6.3
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 11/82 (13%)
Query: 12 PEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPR---IVILGPPAS 68
P Q E ++LM+ ++ + L DP P ++ L + + + R I++LGP S
Sbjct: 1937 PSASQVLAEPMTYKLMKPLVVEELQQVGLDPSPDILGSLEQLSQALSRASGILLLGPAGS 1996
Query: 69 GKTTIAMWLCKHLNSSLLTLEN 90
GKTT C H SL ++N
Sbjct: 1997 GKTT-----CWH---SLFKIQN 2010
>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
Length = 1822
Score = 29.6 bits (65), Expect = 6.3
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Query: 102 EARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQA 148
++ +L + K++P LLV +I + E + Q ILDG P T QA
Sbjct: 689 KSEQLLKKGKSIPDVLLVDIIVNAINEIP-VNQDCILDGFPMTLNQA 734
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 29.6 bits (65), Expect = 6.3
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 17/94 (18%)
Query: 138 LDGIPETREQALRIQTLGIT-------PRHVIVLSAPDTVLIERNLGKRIDPQTGEIYH- 189
L+ +PE E +R+QT+ ++ P + + +T+LI N +DPQ ++
Sbjct: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
Query: 190 -TTFDWPPESEIQNR--LMVPEDISELETAQKLL 220
TT D +QN L +P ++ + LL
Sbjct: 544 LTTLD------LQNNDLLQIPPELGNCVNLRTLL 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,950,762
Number of Sequences: 37866
Number of extensions: 842046
Number of successful extensions: 2391
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2284
Number of HSP's gapped (non-prelim): 88
length of query: 479
length of database: 18,247,518
effective HSP length: 106
effective length of query: 373
effective length of database: 14,233,722
effective search space: 5309178306
effective search space used: 5309178306
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.