Search of human proteins with 226498192

Search of human proteins with 226498192

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226498192 atonal homolog 8 [Homo sapiens]
         (321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226498192 atonal homolog 8 [Homo sapiens]                          656   0.0  
gi|98986461 neurogenic differentiation 2 [Homo sapiens]                77   2e-14
gi|121114306 neurogenic differentiation 1 [Homo sapiens]               68   1e-11
gi|38455396 neurogenin 1 [Homo sapiens]                                67   2e-11
gi|34147558 lymphoblastic leukemia derived sequence 1 [Homo sapi...    67   2e-11
gi|4507363 T-cell acute lymphocytic leukemia 1 [Homo sapiens]          67   3e-11
gi|153792190 neurogenic differentiation 4 [Homo sapiens]               65   1e-10
gi|30039710 pancreas specific transcription factor, 1a [Homo sap...    64   2e-10
gi|27475985 neurogenic differentiation 6 [Homo sapiens]                63   3e-10
gi|31077092 neurogenin 2 [Homo sapiens]                                62   5e-10
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]                61   2e-09
gi|29126247 basic helix-loop-helix family, member a15 [Homo sapi...    60   2e-09
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     60   3e-09
gi|33356148 formin-like 1 [Homo sapiens]                               60   3e-09
gi|153792074 proline rich 12 [Homo sapiens]                            59   4e-09
gi|157168329 formin 1 [Homo sapiens]                                   59   6e-09
gi|4885075 atonal homolog 1 [Homo sapiens]                             59   6e-09
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    59   6e-09
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             59   8e-09
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...    59   8e-09
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    59   8e-09
gi|126090663 zinc finger homeodomain 4 [Homo sapiens]                  59   8e-09
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]         58   1e-08
gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 ...    58   1e-08
gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [...    58   1e-08
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    58   1e-08
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    57   3e-08
gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 ...    56   4e-08
gi|118498339 EMI domain containing 2 [Homo sapiens]                    56   4e-08
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    56   5e-08

>gi|226498192 atonal homolog 8 [Homo sapiens]
          Length = 321

 Score =  656 bits (1692), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGL 60
           MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGL
Sbjct: 1   MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVATNGL 60

Query: 61  RDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPG 120
           RDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPG
Sbjct: 61  RDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPG 120

Query: 121 LPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVR 180
           LPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVR
Sbjct: 121 LPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVR 180

Query: 181 PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARER 240
           PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARER
Sbjct: 181 PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARER 240

Query: 241 TRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFS 300
           TRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFS
Sbjct: 241 TRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFS 300

Query: 301 ECVQRCTRTLQAEGRAKKRKE 321
           ECVQRCTRTLQAEGRAKKRKE
Sbjct: 301 ECVQRCTRTLQAEGRAKKRKE 321


>gi|98986461 neurogenic differentiation 2 [Homo sapiens]
          Length = 382

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 57/163 (34%), Positives = 73/163 (44%), Gaps = 25/163 (15%)

Query: 125 PPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPP 184
           PPPPPPAP   APG                     PAR A   P       E+T+  A  
Sbjct: 37  PPPPPPAPGPGAPG---------------------PARAAKPVPLRGEEGTEATL--AEV 73

Query: 185 TRPGESSYSSISHVIYNNHQDSSAS--PRKRPGEATAASSEIKALQQTRRLLANARERTR 242
              GE               D +    P+KR  +    +       + RR  ANARER R
Sbjct: 74  KEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANARERNR 133

Query: 243 VHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARL 285
           +H ++AA + LRK VPCYS  QKLSK+  LR+A NYI +L+ +
Sbjct: 134 MHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEI 176


>gi|121114306 neurogenic differentiation 1 [Homo sapiens]
          Length = 356

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 37/90 (41%), Positives = 53/90 (58%)

Query: 204 QDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYG 263
           +D    P++R  +    +       + RR+ ANARER R+H ++AA + LRK VPCYS  
Sbjct: 75  EDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKT 134

Query: 264 QKLSKLAILRIACNYILSLARLADLDYSAD 293
           QKLSK+  LR+A NYI +L+ +     S D
Sbjct: 135 QKLSKIETLRLAKNYIWALSEILRSGKSPD 164


>gi|38455396 neurogenin 1 [Homo sapiens]
          Length = 237

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 44/111 (39%), Positives = 61/111 (54%), Gaps = 6/111 (5%)

Query: 181 PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEI-KALQQTRRLLANARE 239
           P  P R G  + S  S V     QD     R+R G     S  +  +L+++RR+ AN RE
Sbjct: 44  PPAPARRGAPNISRASEV--PGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRE 101

Query: 240 RTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLA---RLAD 287
           R R+H ++AA +ALR  +P +    KL+K+  LR A NYI +LA   RLAD
Sbjct: 102 RNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLAD 152


>gi|34147558 lymphoblastic leukemia derived sequence 1 [Homo
           sapiens]
          Length = 280

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 58/186 (31%), Positives = 76/186 (40%), Gaps = 26/186 (13%)

Query: 122 PTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPA----------- 170
           P+P P PPP P S  P   E    R     PR+    P      S PP            
Sbjct: 24  PSPAPAPPPKPASPGPPQVEEVGHRGGSSPPRLPPGVPVISLGHSRPPGVAMPTTELGTL 83

Query: 171 -PPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASP---------RKRPGEATAA 220
            PP    ST+  APPT     +     H   N+     A P         ++RP      
Sbjct: 84  RPPLLQLSTLGTAPPTL----ALHYHPHPFLNSVYIGPAGPFSIFPSSRLKRRPSHCELD 139

Query: 221 SSEIKALQQT-RRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYI 279
            +E    Q+  RR+  N+RER R   ++ AF  LRK +P +   +KLSK  +LR+A  YI
Sbjct: 140 LAEGHQPQKVARRVFTNSRERWRQQNVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYI 199

Query: 280 LSLARL 285
             L RL
Sbjct: 200 GFLVRL 205


>gi|4507363 T-cell acute lymphocytic leukemia 1 [Homo sapiens]
          Length = 331

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 72/238 (30%), Positives = 101/238 (42%), Gaps = 28/238 (11%)

Query: 52  PRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRC 111
           P  V  NG+   T R      PV   + +     P GG   AG  G +R     D + R 
Sbjct: 29  PHLVLLNGVAKETSRAAAAEPPV---IELGARGGPGGGP--AGGGGAAR-----DLKGRD 78

Query: 112 FALGAVGPGLPTP----PPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSA 167
            A       +PT     PP P PAP   AP    A+    PG   R++  +PPA  AP+A
Sbjct: 79  AATAEARHRVPTTELCRPPGPAPAP---APASVTAEL---PG-DGRMVQLSPPALAAPAA 131

Query: 168 PPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKAL 227
           P    A   S  +P      G         +   N++      ++RP       ++    
Sbjct: 132 PGR--ALLYSLSQPLASLGSGFFGEPDAFPMFTTNNR-----VKRRPSPYEMEITDGPHT 184

Query: 228 QQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARL 285
           +  RR+  N+RER R   ++ AF  LRK +P +   +KLSK  ILR+A  YI  LA+L
Sbjct: 185 KVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKL 242


>gi|153792190 neurogenic differentiation 4 [Homo sapiens]
          Length = 331

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 33/84 (39%), Positives = 53/84 (63%), Gaps = 1/84 (1%)

Query: 204 QDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYG 263
           +D     R+ P +     + ++  +  RR+ ANARERTR+H ++ A + LR+ +PCYS  
Sbjct: 62  EDGEKPKRRGPKKKKMTKARLERFR-ARRVKANARERTRMHGLNDALDNLRRVMPCYSKT 120

Query: 264 QKLSKLAILRIACNYILSLARLAD 287
           QKLSK+  LR+A NYI +L+ + +
Sbjct: 121 QKLSKIETLRLARNYIWALSEVLE 144


>gi|30039710 pancreas specific transcription factor, 1a [Homo
           sapiens]
          Length = 328

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 13/164 (7%)

Query: 126 PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPT 185
           P PP AP + AP  P +    EP        C     P    P +P +PP     P    
Sbjct: 72  PAPPAAPLALAP--PSSGGLGEPDDGGGGGYCCETGAPPGGFPYSPGSPPSCLAYPCA-- 127

Query: 186 RPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHT 245
             G +  S  + +   +   ++A+ R+R      + +E++ L+Q     AN RER R+ +
Sbjct: 128 --GAAVLSPGARLRGLSGAAAAAARRRR---RVRSEAELQQLRQA----ANVRERRRMQS 178

Query: 246 ISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLD 289
           I+ AFE LR  +P   Y ++LSK+  LR+A  YI  L+ L   D
Sbjct: 179 INDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQAD 222


>gi|27475985 neurogenic differentiation 6 [Homo sapiens]
          Length = 337

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 35/82 (42%), Positives = 49/82 (59%)

Query: 204 QDSSASPRKRPGEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYG 263
           +D +  PR+R       +       + RR  ANARER R+H ++ A + LRK VPCYS  
Sbjct: 68  EDENGLPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKT 127

Query: 264 QKLSKLAILRIACNYILSLARL 285
           QKLSK+  LR+A NYI +L+ +
Sbjct: 128 QKLSKIETLRLAKNYIWALSEI 149


>gi|31077092 neurogenin 2 [Homo sapiens]
          Length = 272

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 36/86 (41%), Positives = 53/86 (61%), Gaps = 9/86 (10%)

Query: 211 RKRPGEATAAS------SEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQ 264
           ++RP  A A S        ++ +++TRRL AN RER R+H ++AA +ALR+ +P +    
Sbjct: 87  KRRPSRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDA 146

Query: 265 KLSKLAILRIACNYILSLA---RLAD 287
           KL+K+  LR A NYI +L    RLAD
Sbjct: 147 KLTKIETLRFAHNYIWALTETLRLAD 172


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 49/153 (32%), Positives = 57/153 (37%), Gaps = 32/153 (20%)

Query: 69  PVPVPVPVPVPVAPA-------------VPPRGGTDTAGERGGSRAPEVSDARKRCFALG 115
           P P P P P P APA             VPPR  +          A  V D  +R     
Sbjct: 511 PAPAPAPAPAP-APALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPA 569

Query: 116 AVGPGLPTP--------PPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSA 167
              P +P P        PP PP  P S +PG P+A P R  G   R     PP       
Sbjct: 570 PARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPP------L 623

Query: 168 PPAPPAPPESTVRPAP----PTRPGESSYSSIS 196
           PP PP P     R +P    P  PG +S S +S
Sbjct: 624 PPTPPQPARRQSRRSPASPSPASPGPASPSPVS 656



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 40/160 (25%), Positives = 52/160 (32%), Gaps = 25/160 (15%)

Query: 49  APEPRAVATNGLRDRTHRLQPVPVPVPVPV-------PVAPAVPPRGGTDTAGERGGSRA 101
           +P   A     +  RT R  P    +P P        P AP +PP  G+           
Sbjct: 550 SPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGT-------- 601

Query: 102 PEVSDARKRCFALGAVGPGLPTPPPPPPPA----------PQSQAPGGPEAQPFREPGLR 151
           P+    R    +L A     P PP PP PA          P   +PG     P       
Sbjct: 602 PQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPA 661

Query: 152 PRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESS 191
              L  A     AP A    P PP    +P P +   E++
Sbjct: 662 QVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN 701



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 32/112 (28%), Positives = 38/112 (33%), Gaps = 32/112 (28%)

Query: 116 AVGPGLPTPPPPPPPAP---------------QSQAPGGP-----------EAQPFREPG 149
           AV     TP P P PAP               +S+ P  P            A P  +  
Sbjct: 503 AVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMA 562

Query: 150 LRPRILLCAPPARPAP------SAPPAPPAPPESTVRPAPPTRPGESSYSSI 195
            R +    A P  P P      S+PPAPP PP S     P   P     SS+
Sbjct: 563 RRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSL 614


>gi|29126247 basic helix-loop-helix family, member a15 [Homo
           sapiens]
          Length = 189

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 44/128 (34%), Positives = 61/128 (47%), Gaps = 11/128 (8%)

Query: 159 PPARPAP----SAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRP 214
           PP R AP     A P    P  S   P P    G  S  + +       +      R+RP
Sbjct: 7   PPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAA-----RAPGEGRRRRP 61

Query: 215 GEATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRI 274
           G +        ++Q  RRL +N RER R+H ++ AF+ALR+ +P     +KLSK+  L +
Sbjct: 62  GPSGPGGRRDSSIQ--RRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTL 119

Query: 275 ACNYILSL 282
           A NYI SL
Sbjct: 120 AKNYIKSL 127


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 42/122 (34%), Positives = 47/122 (38%), Gaps = 5/122 (4%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAP---EVSDARKRCFALGAVGPGLPTPP 125
           P P P P P PVA A P R     A       +P   +     +R   L A  P    PP
Sbjct: 129 PTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPP 188

Query: 126 PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPT 185
              PPA   +AP  P A   REP L P     APP +  P  P   P P    VR     
Sbjct: 189 AVAPPAGPRRAP--PPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRAGGAA 246

Query: 186 RP 187
           RP
Sbjct: 247 RP 248



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 34/113 (30%), Positives = 38/113 (33%), Gaps = 27/113 (23%)

Query: 85  PPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQP 144
           P RG T  A  R    AP  + A                  PPP PAP         A P
Sbjct: 102 PRRGATPPAPPRAPRGAPAAAAAAA----------------PPPTPAPPPPPAPVAAAAP 145

Query: 145 FREPGLRPRILLCAP---PARPAP--------SAPPAPPAPPESTVRPAPPTR 186
            R P          P   PA+P P        +APP  PA P +   PA P R
Sbjct: 146 ARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRR 198



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 46/171 (26%), Positives = 53/171 (30%), Gaps = 62/171 (36%)

Query: 63  RTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLP 122
           R  R  P+  P P     APA PP      A   G  RAP          A+ A  P LP
Sbjct: 170 RAQRAAPLAAPPP-----APAAPPA----VAPPAGPRRAPPP--------AVAAREPPLP 212

Query: 123 TPPPPPPPAPQSQAPGGPEAQPFREPGL-------------------------------- 150
            PP PP P PQ Q P  P+ QP  E G                                 
Sbjct: 213 PPPQPPAP-PQQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRG 271

Query: 151 ------------RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGE 189
                       R R+      A   P       APP ++ RP+   R GE
Sbjct: 272 RVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGE 322



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 24/72 (33%), Positives = 27/72 (37%), Gaps = 23/72 (31%)

Query: 129 PPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAP-----------PAPPES 177
           PPAP    P  P   P             APP  PAP  PPAP            A   +
Sbjct: 108 PPAP----PRAPRGAP-------AAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAA 156

Query: 178 TVRPAP-PTRPG 188
           T  P+P P +PG
Sbjct: 157 TAPPSPGPAQPG 168


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 43/118 (36%), Positives = 50/118 (42%), Gaps = 23/118 (19%)

Query: 78  VPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP------GLPTPPPPPPPA 131
           +PVA A P  G   T G   GS +P+++ A +   A GA  P      GLP+P   PP A
Sbjct: 504 LPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEP--APGAAPPPPPPLPGLPSPQEAPPSA 561

Query: 132 PQS--QAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRP 187
           P      PG PE  P             APP       PP PP PP  T  P PP  P
Sbjct: 562 PPQAPPLPGSPEPPP-------------APPLPGDLPPPPPPPPPPPGTDGPVPPPPP 606



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 35/118 (29%), Positives = 42/118 (35%), Gaps = 13/118 (11%)

Query: 48  EAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVP-----PRGGTDTAGERGGSRAP 102
           +AP P     +   D     +P P   P P P  P +P     P      A    GS  P
Sbjct: 515 DAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGS--P 572

Query: 103 EVSDARKRCFALGAVGPGLPTPP------PPPPPAPQSQAPGGPEAQPFREPGLRPRI 154
           E   A      L    P  P PP      PPPPP P     G P+A   R+  L P +
Sbjct: 573 EPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGV 630


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 54/174 (31%), Positives = 64/174 (36%), Gaps = 41/174 (23%)

Query: 73   PVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAP 132
            P   P    P  PP  G  +A   G    P + +               P P PPP P P
Sbjct: 1422 PPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEK--------------PPPTPPPAPTP 1467

Query: 133  QSQAPGGPEAQPFREPGL-RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESS 191
            Q Q P  P   P  +P L  P  L+   P+ P P  PP PP PP +   P PP  P    
Sbjct: 1468 QPQPPPPP---PPPQPALPSPPPLVAPTPSSPPP--PPLPPPPPPAMPSPPPPPPP---- 1518

Query: 192  YSSISHVIYNNHQDSSASPRKRPGEATAA-SSEIKALQQTRRL-LANARERTRV 243
                           +A+P   P E  AA S E   L  TR L LA  +E   V
Sbjct: 1519 ---------------AAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAV 1557



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 38/151 (25%)

Query: 95  ERGGSRAPEVSDARKRCFALGA--VGPGLPTPPPPPPPAPQSQAP---------GGPEAQ 143
           ERGG   PE        +  GA  +G  L   PPPPPP  QS  P         GGP+  
Sbjct: 733 ERGGE-TPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLP 791

Query: 144 ---PFREPGLRPRILLCAPPARPAPS--------------APPAPPAPPESTVRPAPPTR 186
              P   P L P +L  AP   P+ S              AP  PP PP     P PP  
Sbjct: 792 LVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPP-----PPPPPM 846

Query: 187 PGESSYSSISHVIYNNHQDSSASPRKRPGEA 217
           P +      SH +    + ++ SPR RP E+
Sbjct: 847 PLQLEAHLRSHGL----EPAAPSPRLRPEES 873



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 35/115 (30%), Positives = 38/115 (33%), Gaps = 41/115 (35%)

Query: 69   PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPP--- 125
            P P P P P P  P  PP               P+               P LP+PP   
Sbjct: 1459 PTPPPAPTPQPQPPPPPP--------------PPQ---------------PALPSPPPLV 1489

Query: 126  ------PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP 174
                  PPPPP P    P  P   P   P   P   L APP  PA  +P  P  P
Sbjct: 1490 APTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAP---LAAPPEEPAAPSPEDPELP 1541



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 28/81 (34%), Positives = 35/81 (43%), Gaps = 20/81 (24%)

Query: 118  GPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGL---------RPRILLCAPPARPAPSA- 167
            GP   + P  PP AP +  PG P       PGL          P +L   PP  P P+  
Sbjct: 1412 GPKDTSTPDGPPLAPAAAVPGPPPL-----PGLPSANSNGTPEPPLLEEKPPPTPPPAPT 1466

Query: 168  ----PPAPPAPPESTVRPAPP 184
                PP PP PP+  + P+PP
Sbjct: 1467 PQPQPPPPPPPPQPAL-PSPP 1486



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 58/205 (28%), Positives = 71/205 (34%), Gaps = 55/205 (26%)

Query: 22  GLKKLKRKGKEPARRANGYKTFRLDLEAPEPRAVAT----NGLRDRTHRLQPVPVPVPVP 77
           GL +LK K K P R            E PE  A +      G ++    LQ  P P P P
Sbjct: 721 GLGRLKEKKKGPERGG----------ETPEGLATSVVHYGAGAKELGAFLQKSPPPPP-P 769

Query: 78  VPVAPAVPPRGGTDTAGERGG-------------------SRAPEVSDARKRC---FALG 115
              +    P G      E GG                   S AP  S +  +        
Sbjct: 770 TAQSTQPTPHG---LLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEP 826

Query: 116 AVGPGLPTPPPPPPPAP---------QSQAPGGPEAQPFREPGLRPRILLCAPPARP--A 164
           A   G P PPPPPPP P           ++ G   A P   P LRP   L  P A     
Sbjct: 827 ATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAP--SPRLRPEESLDPPGAMQELL 884

Query: 165 PSAPPAPPAPPESTVRPAPPTRPGE 189
            +  P PPAP ++ V   PP   G+
Sbjct: 885 GALEPLPPAPGDTGV--GPPNSEGK 907



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 28/80 (35%), Positives = 32/80 (40%), Gaps = 10/80 (12%)

Query: 69   PVPVPVPVPVPVAPAVPPRG---GTDTAGERGGSRAPEVSDARKRCFALGAVGPGL---- 121
            P P P P   P  P  P R    G +T G       P    +      LG +  G     
Sbjct: 980  PPPGP-PAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAA 1038

Query: 122  --PTPPPPPPPAPQSQAPGG 139
              P PPPPPPPAP S+  GG
Sbjct: 1039 PPPPPPPPPPPAPASEPKGG 1058



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 46/189 (24%), Positives = 58/189 (30%), Gaps = 60/189 (31%)

Query: 50   PEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAG-----ERGGSRAPEV 104
            PE        +++    L+P+P P P    V P  P   G D AG        G++AP  
Sbjct: 870  PEESLDPPGAMQELLGALEPLP-PAPGDTGVGP--PNSEGKDPAGAYRSPSPQGTKAPRF 926

Query: 105  SDARKRCFA--------------------------LGAVGP----GLPTPPPPPPPAPQS 134
                  CF                            G  GP    G P     PPP P +
Sbjct: 927  VPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPA 986

Query: 135  QAPGGPEA----------------QPFREPGL------RPRILLCAPPARPAPSAPPAPP 172
              P GP                   P + P L       P  L+ + P + AP  PP PP
Sbjct: 987  YDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPP 1046

Query: 173  APPESTVRP 181
             PP     P
Sbjct: 1047 PPPAPASEP 1055



 Score = 32.7 bits (73), Expect = 0.44
 Identities = 29/99 (29%), Positives = 33/99 (33%), Gaps = 12/99 (12%)

Query: 83   AVPPRGGTDTAGERGGSRAPEVSD-----ARKRCFALGAVGPGLPTPPPPPPPAPQSQAP 137
            A PP    D     G    P   D        R    G   PGL   P  PP  P +   
Sbjct: 965  AGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTV-- 1022

Query: 138  GGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPE 176
                A+P       P     APP  P P  PPAP + P+
Sbjct: 1023 ---NAEPLGLIQSGPH--QAAPPPPPPPPPPPAPASEPK 1056



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 40/138 (28%), Positives = 46/138 (33%), Gaps = 33/138 (23%)

Query: 85  PPRGGTDTAGERGGSRAPEVSDARKRCF--ALGAVGPGLPTPPPPPPPA-PQSQAPGGPE 141
           P   G   AG  GG   P +     +      GA   G   PPPP   A P+ Q+ GGP 
Sbjct: 365 PEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPA 424

Query: 142 AQ--------------PFREPGLRPRILL------------CAPPARPAPSAPPAPPAPP 175
           A                   PG +P+ LL             A     APS    PP PP
Sbjct: 425 AAYATGKASGAGGAGGQAYSPG-QPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPP 483

Query: 176 ESTVRPAPPTRPGESSYS 193
                P PP      SYS
Sbjct: 484 SG---PPPPGLATCQSYS 498



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 33/123 (26%), Positives = 46/123 (37%), Gaps = 19/123 (15%)

Query: 124  PPPPPPPAPQSQAP---GGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVR 180
            PP P   + Q++ P   GG  A P + P         APP +P          PPE T  
Sbjct: 1670 PPVPVRRSGQAKNPVSAGGSSAPPPKAP---------APPPKPETPEKTTSEKPPEQTPE 1720

Query: 181  PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTR--RLLANAR 238
             A P  P      S+   +    +    +  +RP     A+S     +QTR  R LA  +
Sbjct: 1721 TAMPEPPAPEK-PSLLRPVEKEKEKEKVTRGERPLRGERATSG----RQTRPERSLATGQ 1775

Query: 239  ERT 241
              T
Sbjct: 1776 PAT 1778



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 24/78 (30%), Positives = 32/78 (41%), Gaps = 13/78 (16%)

Query: 113  ALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPP 172
            A   V  G  + PPP  PAP  + P  PE     +           PP +   +A P PP
Sbjct: 1680 AKNPVSAGGSSAPPPKAPAPPPK-PETPEKTTSEK-----------PPEQTPETAMPEPP 1727

Query: 173  APPE-STVRPAPPTRPGE 189
            AP + S +RP    +  E
Sbjct: 1728 APEKPSLLRPVEKEKEKE 1745



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 40/145 (27%), Positives = 47/145 (32%), Gaps = 34/145 (23%)

Query: 67  LQPVPVPVPVPVPVAPAVPPRGGTDT----AGERGGSRAPEVSDARKRCFALGAVGPGLP 122
           L P   P   P P  P  PPR         A     + A E S  +   F+  A GP  P
Sbjct: 219 LGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPP 278

Query: 123 T--------------------PPPPPPPAPQSQ---APGGPEAQPFREPGLRPRILLCAP 159
                                PPPPPPPA   Q   + GG     +   G R   L C+P
Sbjct: 279 ERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGG----SYPSMGHRAN-LACSP 333

Query: 160 --PARPAPSAPPAPPAPPESTVRPA 182
                P+P A     A P      A
Sbjct: 334 LGGGEPSPGAGEPSKAGPSGATAGA 358


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 50/161 (31%), Positives = 60/161 (37%), Gaps = 43/161 (26%)

Query: 73  PVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAP 132
           P P  +P  P +P       +G    S AP +           + GP LP PPPPPPP P
Sbjct: 647 PPPASIPPPPPLP-------SGLGSLSPAPPMPPV--------SAGPPLPPPPPPPPPLP 691

Query: 133 QSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRP--APPTRPGES 190
              + G P   P              PP  P   APP P  PP +   P  APP  PG  
Sbjct: 692 PPSSAGPPPPPP--------------PPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPG-- 735

Query: 191 SYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTR 231
                  + +     SS  PRK    A   S  +K L  TR
Sbjct: 736 -------LFFGLGSSSSQCPRK---PAIEPSCPMKPLYWTR 766



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 29/74 (39%), Positives = 32/74 (43%), Gaps = 6/74 (8%)

Query: 121 LPTPP---PPPPPAPQ---SQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP 174
           LP PP   PPPPP P    S +P  P       P L P      P   P+ + PP PP P
Sbjct: 645 LPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPP 704

Query: 175 PESTVRPAPPTRPG 188
           P     PAPP   G
Sbjct: 705 PPLPNSPAPPNPGG 718



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 52/205 (25%), Positives = 66/205 (32%), Gaps = 66/205 (32%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPP 128
           P+P P P P P+ P  P   G                                P PPPPP
Sbjct: 679 PLPPPPPPPPPLPP--PSSAG--------------------------------PPPPPPP 704

Query: 129 PPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPS-APPAPP------------APP 175
           PP P S AP  P                  PPA P P  APP PP             P 
Sbjct: 705 PPLPNSPAPPNPGG---------------PPPAPPPPGLAPPPPPGLFFGLGSSSSQCPR 749

Query: 176 ESTVRPAPPTRPGESSYSSISHVIYN---NHQDSSASPRKR-PGEATAASSEIKALQQTR 231
           +  + P+ P +P   +   IS    N      DS   P  R P E     S+    Q+ +
Sbjct: 750 KPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKK 809

Query: 232 RLLANARERTRVHTISAAFEALRKQ 256
            L     ++ +V  I    +  R Q
Sbjct: 810 PLSETYEKKNKVKKIIKLLDGKRSQ 834


>gi|4885075 atonal homolog 1 [Homo sapiens]
          Length = 354

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 56/193 (29%), Positives = 77/193 (39%), Gaps = 34/193 (17%)

Query: 121 LPTPPPPPPPAPQSQAPGGPEAQPFRE--PGLRPRILLCAPPARPAPSAPPAPPA--PPE 176
           LP PPPPP P    QA   P   P         PR  L AP  +   +A  A      PE
Sbjct: 28  LPQPPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWL-APTLQGICTARAAQYLLHSPE 86

Query: 177 STVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPG--------------------- 215
                A   R        +            AS  K PG                     
Sbjct: 87  LGASEAAAPRDEVDGRGELVR-----RSSGGASSSKSPGPVKVREQLCKLKGGVVVDELG 141

Query: 216 ---EATAASSEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAIL 272
              +   +S ++  +Q+ RRL ANARER R+H ++ AF+ LR  +P ++  +KLSK   L
Sbjct: 142 CSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETL 201

Query: 273 RIACNYILSLARL 285
           ++A  YI +L+ L
Sbjct: 202 QMAQIYINALSEL 214


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 38/113 (33%), Positives = 46/113 (40%), Gaps = 23/113 (20%)

Query: 79  PVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPG 138
           P+ P   PR G  +        AP   +            P  PTPPPPPPP P    P 
Sbjct: 143 PLIPPASPRLGNTSEAHGAARTAPPRPNVP---------APPPPTPPPPPPPLP----PP 189

Query: 139 GPEAQPFREPGLRP-------RILLCAPPARPAPSAPPAPPAPPESTVRPAPP 184
            P + P + P + P        + + AP   P P APP PP PP  T  P PP
Sbjct: 190 LPSSSPIKTPLVSPPGPLTKGNLPVVAP---PVPCAPPPPPPPPPPTPPPLPP 239



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 53/176 (30%), Positives = 67/176 (38%), Gaps = 27/176 (15%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTA-----GERGGSRAPEVSDARKRCFALGAVGPGLPT 123
           P P P P P P+ P +P      T      G       P V+     C       P  PT
Sbjct: 175 PPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVP-CAPPPPPPPPPPT 233

Query: 124 PPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAP---------PARPAPSA--PPAPP 172
           PPP PP +  S     P+  P   P + P + L  P         PA PA  A  PPAPP
Sbjct: 234 PPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPP 293

Query: 173 AP--------PESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAA 220
            P        P +++ PAPP  PG +S S     +        A P+K   +A  A
Sbjct: 294 PPLPPYASCSPRASL-PAPPL-PGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPA 347



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 50/184 (27%), Positives = 70/184 (38%), Gaps = 49/184 (26%)

Query: 60  LRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP 119
           L D+  + Q  P+ +P   P  P +PP G      E     A    DA++          
Sbjct: 243 LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEP----ASPAQDAQEP--------- 289

Query: 120 GLPTPPPPPPP----APQSQAPGGP----EAQPFREPGLRPRI-LLCAPPARPAPSAPPA 170
             P PPPP PP    +P++  P  P     +     P L P+     APP +    A PA
Sbjct: 290 --PAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPA 347

Query: 171 PPAPPES-------------------TVRPAPPTRPGESSYSSISHVIYNNHQDSSASPR 211
           PPAPP S                      PAPP R   +  SS       + Q ++ +P 
Sbjct: 348 PPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSS------KSQQATAWTPT 401

Query: 212 KRPG 215
           ++PG
Sbjct: 402 QQPG 405



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 22/58 (37%), Positives = 23/58 (39%), Gaps = 25/58 (43%)

Query: 121 LPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPEST 178
           +P PPPPPPP P    P G                  APP       PP P APP ST
Sbjct: 1   MPVPPPPPPPLPPPPPPLG------------------APP-------PPPPSAPPVST 33



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 39/134 (29%), Positives = 49/134 (36%), Gaps = 26/134 (19%)

Query: 81  APAVPPRGGTD-----TAGERGGSRAPEVSD-----------ARKRCFALGAVGPGLPTP 124
           AP +    GT+     +A  RG S  P + D           A +R  A G  G G    
Sbjct: 70  APQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQG---- 125

Query: 125 PPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPP---ARPAPSAPPAPPAPPESTVRP 181
             P   AP  + P    + P   P   PR+   +     AR AP  P  P  PP +   P
Sbjct: 126 --PGSRAPSPRLPNKTISGPLIPPA-SPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPP 182

Query: 182 APPTRPGESSYSSI 195
            PP  P   S S I
Sbjct: 183 PPPLPPPLPSSSPI 196



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 17/43 (39%), Positives = 19/43 (44%), Gaps = 3/43 (6%)

Query: 119 PGLPTPPPP---PPPAPQSQAPGGPEAQPFREPGLRPRILLCA 158
           P LP PPPP   PPP P S  P   +    R    + R  L A
Sbjct: 9   PPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLA 51



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 14/35 (40%), Positives = 17/35 (48%)

Query: 160 PARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSS 194
           P  P P  P  PP PP     P PP+ P  S+ +S
Sbjct: 2   PVPPPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTS 36



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 12/26 (46%), Positives = 13/26 (50%)

Query: 119 PGLPTPPPPPPPAPQSQAPGGPEAQP 144
           P  P PP PPPP P    P  P + P
Sbjct: 4   PPPPPPPLPPPPPPLGAPPPPPPSAP 29



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 26/67 (38%)

Query: 119 PGLPTPPPP-PPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPES 177
           P  P PPPP PPP P   AP                     PP  P PSAPP   +   S
Sbjct: 2   PVPPPPPPPLPPPPPPLGAP---------------------PP--PPPSAPPV--STDTS 36

Query: 178 TVRPAPP 184
           ++R A P
Sbjct: 37  SLRRADP 43



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 13/28 (46%), Positives = 14/28 (50%)

Query: 117 VGPGLPTPPPPPPPAPQSQAPGGPEAQP 144
           V P  P P PPPPP   +  P  P A P
Sbjct: 3   VPPPPPPPLPPPPPPLGAPPPPPPSAPP 30


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 49/150 (32%), Positives = 55/150 (36%), Gaps = 31/150 (20%)

Query: 52  PRAVATNGLRDRTHRLQPVPVPV--PVPVPVAPAVPPRGG----TDTAGERGGSRAPEVS 105
           PR     G + R+  L PVP+ +  P P P  P  P RGG       A  R G   P   
Sbjct: 327 PRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPP 386

Query: 106 DARKRCFALGAVGPGLPTPPPPPPPAPQS-QAPGGPEAQPFREPG--------------- 149
                    GA GP +P PPPPPPP P S   P  P   P   P                
Sbjct: 387 ---------GAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQ 437

Query: 150 LRPRILLCAPPARPAPSAPPAPPAPPESTV 179
           +R  I L   P  P  SA   PP   E  V
Sbjct: 438 IRQGIQLNKTPGAPESSALQPPPQSSEGLV 467



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 41/132 (31%), Positives = 47/132 (35%), Gaps = 28/132 (21%)

Query: 60  LRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP 119
           +R    R +P+P P P         P RGG          R P V   + R   L  V  
Sbjct: 303 VRQEMRRQEPLPPPPP---------PSRGGNQLP------RPPIVGGNKGRSGPLPPVPL 347

Query: 120 GLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTV 179
           G+  PPPP P  P     GGP   P    G    +    PP  P    PP PP PP    
Sbjct: 348 GI-APPPPTPRGPPPPGRGGPPPPPPPATGRSGPL----PPPPPGAGGPPMPPPPP---- 398

Query: 180 RPAPPTRPGESS 191
               P  P  SS
Sbjct: 399 ----PPPPPPSS 406


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 44/143 (30%), Positives = 52/143 (36%), Gaps = 23/143 (16%)

Query: 60  LRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP 119
           +++   R  P P P     P  P  PP           G  AP    +R    A     P
Sbjct: 268 VKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPP 327

Query: 120 G-----LPTPPP-----PPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPP 169
                 +P PPP     PPPPA  S AP GP   P       P +L   P A P P  PP
Sbjct: 328 SRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPP-------PSVLGVGPVAPPPPPPPP 380

Query: 170 APPAPPESTVRPAPPTRPGESSY 192
            PP P      P PP  P +  +
Sbjct: 381 PPPGP------PPPPGLPSDGDH 397



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 29/80 (36%), Positives = 33/80 (41%), Gaps = 14/80 (17%)

Query: 116 AVGPGLPTPPPPPPPAPQSQAP--------GGPEAQPFREPGLRPRILLCAPPAR-PAPS 166
           AV   L    PPPPP  +   P         GP   P R  G  P      PP+R P  +
Sbjct: 267 AVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPP-----PPPSRAPTAA 321

Query: 167 APPAPPAPPESTVRPAPPTR 186
            PP PP+ P   V P PP R
Sbjct: 322 PPPPPPSRPSVAVPPPPPNR 341


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 33/72 (45%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 114 LGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPA 173
           L  +GP  PTP P PPP    +AP    A PF  PG  P +    P A P PSA P P A
Sbjct: 638 LQPMGPTCPTPAPVPPP----EAPSPFRAPPFHPPGPMPSVG-SMPSAGPMPSAGPMPSA 692

Query: 174 PPESTVRPAPPT 185
            P  + RP PPT
Sbjct: 693 GPVPSARPGPPT 704



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 29/86 (33%), Positives = 33/86 (38%), Gaps = 16/86 (18%)

Query: 67  LQPVPVPVP---VPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPT 123
           L P+P P P    P P+AP  PP        +      P             A GP LP 
Sbjct: 795 LPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELP------------AAPGP-LPP 841

Query: 124 PPPPPPPAPQSQAPGGPEAQPFREPG 149
           PPPPPPP P       P+  P   PG
Sbjct: 842 PPPPPPPVPGPVTLPPPQLVPEGTPG 867



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 28/73 (38%), Positives = 28/73 (38%), Gaps = 16/73 (21%)

Query: 119 PGLPTPPP----PPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP 174
           P LP PPP    PPP AP       P      EP           PA P P  PP PP P
Sbjct: 796 PPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPE--------ELPAAPGPLPPPPPPPP 847

Query: 175 PESTVRPAPPTRP 187
           P     P P T P
Sbjct: 848 PV----PGPVTLP 856



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 30/79 (37%), Positives = 34/79 (43%), Gaps = 9/79 (11%)

Query: 117 VGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGL----RPRILLCAPPARPAPSAPPAPP 172
           V  GLP P PPPPP+  +  P  P   P   P +     P  L  AP   P P  PP PP
Sbjct: 791 VPEGLP-PLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPP-PPPPP 848

Query: 173 APPESTVRP---APPTRPG 188
            P   T+ P    P   PG
Sbjct: 849 VPGPVTLPPPQLVPEGTPG 867



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 25/76 (32%), Positives = 31/76 (40%), Gaps = 2/76 (2%)

Query: 115  GAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP 174
            G V  G P PP  PP  P  ++P   + +P  EPGL   +    P       A  AP   
Sbjct: 970  GEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVE--EPGTEEERGADTAPTLA 1027

Query: 175  PESTVRPAPPTRPGES 190
            PE+        R GES
Sbjct: 1028 PEALPSQGEVEREGES 1043



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 32/110 (29%), Positives = 43/110 (39%), Gaps = 22/110 (20%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPP 128
           P P+P    +P A  +P  G   +AG    +R    + A      LG   PGL + PP  
Sbjct: 668 PGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANH----LGLSVPGLVSVPPRL 723

Query: 129 PPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPEST 178
            P P++   G  E     +P L             APS  P P  PP+ T
Sbjct: 724 LPGPENHRAGSNE-----DPIL-------------APSGTPPPTIPPDET 755


>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
          Length = 3571

 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 31/73 (42%), Positives = 35/73 (47%), Gaps = 5/73 (6%)

Query: 117  VGPGLP-TPPPPPPPAPQSQAPGGPEAQ-PFREPGLRPRILLCAPPARPAPSAPPAPPAP 174
            + P  P TPPPPPPP P   AP  P +  P + P      L   PP  P P  PP PP P
Sbjct: 1950 ISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPP 2009

Query: 175  PESTVRPAPPTRP 187
            P     P PP+ P
Sbjct: 2010 PPP---PPPPSAP 2019



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 27/76 (35%), Positives = 29/76 (38%), Gaps = 13/76 (17%)

Query: 69   PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPP 128
            P P P P P+P AP  P           G  + P           L A  P  P PPPPP
Sbjct: 1958 PPPPPPPPPLPPAPPQP--------SSMGPVKIPNTVST-----PLQAPPPTPPPPPPPP 2004

Query: 129  PPAPQSQAPGGPEAQP 144
            PP P    P  P A P
Sbjct: 2005 PPPPPPPPPPPPSAPP 2020



 Score = 35.4 bits (80), Expect = 0.068
 Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 19/81 (23%)

Query: 119  PGLPTPPPPPPPAPQ--SQAPGGPE-AQPFREPGL-----------RPRILLCAPPARPA 164
            PGLP  PP   P     S  PG P+ +     PG             P + L + P +P 
Sbjct: 3054 PGLPGLPPVLLPGMNGPSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPL 3113

Query: 165  PSAPPAPPAPPESTVRPAPPT 185
               PP PP PP     P PP+
Sbjct: 3114 LQTPPPPPPPP-----PPPPS 3129



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 13/26 (50%), Positives = 14/26 (53%)

Query: 122  PTPPPPPPPAPQSQAPGGPEAQPFRE 147
            P PPPPPPP P S   G    Q  +E
Sbjct: 3118 PPPPPPPPPPPSSSLSGQQTEQQNKE 3143



 Score = 32.0 bits (71), Expect = 0.76
 Identities = 11/22 (50%), Positives = 14/22 (63%)

Query: 122  PTPPPPPPPAPQSQAPGGPEAQ 143
            P PPPPPPP P S +  G + +
Sbjct: 3117 PPPPPPPPPPPPSSSLSGQQTE 3138



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 14/37 (37%), Positives = 17/37 (45%), Gaps = 5/37 (13%)

Query: 159  PPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSI 195
            P +  +P  PP PP PP     P PP  P  SS   +
Sbjct: 1949 PISPSSPETPPPPPPPP-----PLPPAPPQPSSMGPV 1980



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 14/51 (27%), Positives = 20/51 (39%)

Query: 164  APSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRP 214
            +PS+P  PP PP     P  P +P       I + +    Q    +P   P
Sbjct: 1951 SPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPP 2001


>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
          Length = 1312

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 56/215 (26%), Positives = 80/215 (37%), Gaps = 32/215 (14%)

Query: 44  RLDLEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPE 103
           RLDL   E   +       R     P+P+PVP  +P             A   G + +P+
Sbjct: 114 RLDLRPGESEDMLELVAEVRIGDRDPIPLPVPSLLPRL----------RAWRTGKTVSPQ 163

Query: 104 VSDARKRC---FALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPP 160
            + +R  C     LG  G G P PPP P  A  S +P    + P             +PP
Sbjct: 164 SNSSRPTCARHLTLGT-GDGGPAPPPAPSSASSSPSPSPSSSSP-------------SPP 209

Query: 161 ARPAPSAPPAPPAPPESTVRPAPPTRPGESSYS--SISHVIYNNHQDSSASPRKRPGEAT 218
             P P APPAPPAP      P  PT   + +YS        Y+  + + ++P    G  +
Sbjct: 210 PPPPPPAPPAPPAPRFDIYDPFHPT---DEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPS 266

Query: 219 AASSEIKALQQTRRLLANARERTRVHTISAAFEAL 253
               E +  ++         E     +IS   E L
Sbjct: 267 PEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 54/194 (27%), Positives = 71/194 (36%), Gaps = 24/194 (12%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSR------APEVSDARKRCFALGAVGPGLP 122
           P P   P     AP  PP+   D+    G  R        E    R+   ++  V  G  
Sbjct: 320 PRPDAQPTQPTPAPGTPPQ--VDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGA 377

Query: 123 TPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAP---PARPAPSAPPAPPAPPESTV 179
             PPP  P   S+   G   QP  EP  R  + L  P    ARP P+A   P A P    
Sbjct: 378 ALPPPLLPPGDSEIEEGEIVQPEEEP--RLALSLFRPGGRAARPTPAASATPTAQP--LP 433

Query: 180 RPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEAT----AASSEIKALQQTRRLLA 235
           +P  P  P    + S+     +   D   + +   GE      AA S    L   R++L 
Sbjct: 434 QPPAPRAPEGDDFLSL-----HAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILT 488

Query: 236 NARERTRVHTISAA 249
             RER R  + S A
Sbjct: 489 QRRERYRQRSPSPA 502



 Score = 35.8 bits (81), Expect = 0.052
 Identities = 30/112 (26%), Positives = 42/112 (37%), Gaps = 8/112 (7%)

Query: 126 PPPPPAPQSQAPGGPEAQPFREPGLRPR-----ILLCAPPARPAPSAPPAPPAPPESTVR 180
           P P PAP   A  GP   P R+   R R         A  +     APPAP +P +S   
Sbjct: 499 PSPAPAPAPAAAAGP---PTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKH 555

Query: 181 PAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSEIKALQQTRR 232
            +   +PG  + SS      +  +  S   R R  +     S     ++ RR
Sbjct: 556 RSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRR 607



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 33/125 (26%), Positives = 42/125 (33%), Gaps = 26/125 (20%)

Query: 37  ANGYKTFRLDLEAPEPRAVATNG-----------LRDRTHRL-QPVPVPVPVPVPVAPAV 84
           ++G    ++DL  P P   A +            L  R  R  Q  P P P P P A A 
Sbjct: 453 SDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAG 512

Query: 85  PPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQP 144
           PP   T     R   R+ E  +A               +   P PPAP S          
Sbjct: 513 PP---TRKKSRRERKRSGEAKEAASS-----------SSGTQPAPPAPASPWDSKKHRSR 558

Query: 145 FREPG 149
            R+PG
Sbjct: 559 DRKPG 563


>gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2
           [Homo sapiens]
          Length = 1132

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 50/154 (32%), Positives = 63/154 (40%), Gaps = 15/154 (9%)

Query: 55  VATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFAL 114
           VA NG  + +H     P+P P+PVPV P   P   T           P+V   +     +
Sbjct: 626 VAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPIT--------VPPPQVPPHQPGPPVV 677

Query: 115 GAVGPGLPTPP-PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPA 173
           GA+ P   TPP   PPP      P  P   PF  PG  P  L    P    P  PP P  
Sbjct: 678 GALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHL----PPGFLPPGPPPPIT 733

Query: 174 PPESTVRPAPPTRPGESSYSSISHVIYNNHQDSS 207
           PP S   P P T P     S+I+ +  +  +D S
Sbjct: 734 PPVSI--PPPHTPPISIPNSTIAGINEDTTKDLS 765



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 28/97 (28%), Positives = 35/97 (36%), Gaps = 24/97 (24%)

Query: 75  PVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQS 134
           P P P  P V P G     G   G   PE  D R++             PP  P   PQ 
Sbjct: 893 PFP-PHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQ-------------PPQQPQQQPQP 938

Query: 135 QAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAP 171
           QAP  P+ Q  ++P          PP++  P     P
Sbjct: 939 QAPQQPQQQQQQQP----------PPSQQPPPTQQQP 965



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 40/164 (24%), Positives = 48/164 (29%), Gaps = 53/164 (32%)

Query: 70  VPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGL-------- 121
           VP   P  +P  P   P       G +G +  P +         LGA  PGL        
Sbjct: 794 VPPAAPTNLPTPPVTQP---VSLLGTQGVAPGPVIGLQAPSTGLLGA-RPGLIPLQRPPG 849

Query: 122 -------------PTPPPP------PPPAPQSQA------------PGGPEAQPFREPGL 150
                        P P PP      PPP P   A            P GP  +P   PGL
Sbjct: 850 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGL 909

Query: 151 ----------RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPP 184
                       R     PP +P     P  P  P+   +  PP
Sbjct: 910 GGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPP 953



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 41/201 (20%), Positives = 66/201 (32%), Gaps = 60/201 (29%)

Query: 102 PEVSDARKR--CFALGAVGPGLPTPPPPPPPAPQSQAPGG----PEAQPFREPG------ 149
           PE  +  K+    A+    P    PP P    P + AP      P   PF  PG      
Sbjct: 256 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQP 315

Query: 150 ----------LRPRIL----------LCAPP--ARPAPSAPPAPPAPP--ESTVRPAPPT 185
                      +PR++          +  PP    P     P PP PP  +  + P PP 
Sbjct: 316 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 375

Query: 186 -RPGESSYSS-----------------------ISHVIYNNHQDSSASPRKRPGEATAAS 221
            +P ++S+ +                       +   + +N +  S S  + P    + S
Sbjct: 376 QQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRS 435

Query: 222 SEIKALQQTRRLLANARERTR 242
                  + RR  + +R+R R
Sbjct: 436 GSRSRRSRHRRSRSRSRDRRR 456



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 24/88 (27%), Positives = 31/88 (35%), Gaps = 24/88 (27%)

Query: 118 GPGLPTPPPP-------PPPAP------------QSQAPGGPE-----AQPFREPGLRPR 153
           GPG    PPP       PP  P                PGGPE      QP ++P  +P+
Sbjct: 878 GPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQ 937

Query: 154 ILLCAPPARPAPSAPPAPPAPPESTVRP 181
                 P +     PP    PP +  +P
Sbjct: 938 PQAPQQPQQQQQQQPPPSQQPPPTQQQP 965


>gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1
           [Homo sapiens]
          Length = 1147

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 50/154 (32%), Positives = 63/154 (40%), Gaps = 15/154 (9%)

Query: 55  VATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFAL 114
           VA NG  + +H     P+P P+PVPV P   P   T           P+V   +     +
Sbjct: 641 VAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPIT--------VPPPQVPPHQPGPPVV 692

Query: 115 GAVGPGLPTPP-PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPA 173
           GA+ P   TPP   PPP      P  P   PF  PG  P  L    P    P  PP P  
Sbjct: 693 GALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHL----PPGFLPPGPPPPIT 748

Query: 174 PPESTVRPAPPTRPGESSYSSISHVIYNNHQDSS 207
           PP S   P P T P     S+I+ +  +  +D S
Sbjct: 749 PPVSI--PPPHTPPISIPNSTIAGINEDTTKDLS 780



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 28/97 (28%), Positives = 35/97 (36%), Gaps = 24/97 (24%)

Query: 75  PVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQS 134
           P P P  P V P G     G   G   PE  D R++             PP  P   PQ 
Sbjct: 908 PFP-PHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQ-------------PPQQPQQQPQP 953

Query: 135 QAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAP 171
           QAP  P+ Q  ++P          PP++  P     P
Sbjct: 954 QAPQQPQQQQQQQP----------PPSQQPPPTQQQP 980



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 40/164 (24%), Positives = 48/164 (29%), Gaps = 53/164 (32%)

Query: 70  VPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGL-------- 121
           VP   P  +P  P   P       G +G +  P +         LGA  PGL        
Sbjct: 809 VPPAAPTNLPTPPVTQP---VSLLGTQGVAPGPVIGLQAPSTGLLGA-RPGLIPLQRPPG 864

Query: 122 -------------PTPPPP------PPPAPQSQA------------PGGPEAQPFREPGL 150
                        P P PP      PPP P   A            P GP  +P   PGL
Sbjct: 865 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGL 924

Query: 151 ----------RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPP 184
                       R     PP +P     P  P  P+   +  PP
Sbjct: 925 GGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPP 968



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 41/201 (20%), Positives = 66/201 (32%), Gaps = 60/201 (29%)

Query: 102 PEVSDARKR--CFALGAVGPGLPTPPPPPPPAPQSQAPGG----PEAQPFREPG------ 149
           PE  +  K+    A+    P    PP P    P + AP      P   PF  PG      
Sbjct: 271 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQP 330

Query: 150 ----------LRPRIL----------LCAPP--ARPAPSAPPAPPAPP--ESTVRPAPPT 185
                      +PR++          +  PP    P     P PP PP  +  + P PP 
Sbjct: 331 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 390

Query: 186 -RPGESSYSS-----------------------ISHVIYNNHQDSSASPRKRPGEATAAS 221
            +P ++S+ +                       +   + +N +  S S  + P    + S
Sbjct: 391 QQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRS 450

Query: 222 SEIKALQQTRRLLANARERTR 242
                  + RR  + +R+R R
Sbjct: 451 GSRSRRSRHRRSRSRSRDRRR 471



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 24/88 (27%), Positives = 31/88 (35%), Gaps = 24/88 (27%)

Query: 118 GPGLPTPPPP-------PPPAP------------QSQAPGGPE-----AQPFREPGLRPR 153
           GPG    PPP       PP  P                PGGPE      QP ++P  +P+
Sbjct: 893 GPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQ 952

Query: 154 ILLCAPPARPAPSAPPAPPAPPESTVRP 181
                 P +     PP    PP +  +P
Sbjct: 953 PQAPQQPQQQQQQQPPPSQQPPPTQQQP 980


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 64/246 (26%), Positives = 91/246 (36%), Gaps = 29/246 (11%)

Query: 8   EDGPWKTVCVKELNGLKKLKR--KGKEPARRANGYKTFR--LDLEAPEPRAVATNG-LRD 62
           ED P  TV  K    LK +++       AR +   KT R  +D + P+P  V  +  LR 
Sbjct: 508 EDSP--TVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRP 565

Query: 63  RTHRLQPVPV-PVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGL 121
                 PVP  P PVP P     PP        +R        S  R+  F   ++   L
Sbjct: 566 PITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRR-------SILREPTFRWTSLTREL 618

Query: 122 PTPPPPPPPAPQSQAPGGPEAQPFR------------EPGLRPRILLCAPPARPAPSAPP 169
           P PPP PPP P    P  P     R            E  L+    +  PP   AP AP 
Sbjct: 619 PPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPE 678

Query: 170 APPAPPESTVRPAPPTRPGESSYSSISHV--IYNNHQDSSASPRKRPGEATAASSEIKAL 227
             P P + +     P   G +++ S+     +      +  SP   P  +    ++ + L
Sbjct: 679 PEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLL 738

Query: 228 QQTRRL 233
           Q  + L
Sbjct: 739 QPLQAL 744



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 45/146 (30%), Positives = 52/146 (35%), Gaps = 26/146 (17%)

Query: 48  EAPEPRAVATNGL---RDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEV 104
           E  E RAVA   +        +L P P+  P P P  P  PP   T           P V
Sbjct: 379 EEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPP--STSPPPPLCPPPPPPV 436

Query: 105 SDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQP---FREPGLRPRILLCAPPA 161
           S                P P PPPPPA + Q    P   P    R+ G RP +       
Sbjct: 437 SPP--------------PLPSPPPPPAQEEQEESPPPVVPATCSRKRG-RPPLTPSQRAE 481

Query: 162 RPAPSAPP---APPAPPESTVRPAPP 184
           R A  A P   +PP P  ST    PP
Sbjct: 482 REAARAGPEGTSPPTPTPSTATGGPP 507



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 27/71 (38%), Positives = 28/71 (39%), Gaps = 10/71 (14%)

Query: 124 PPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAP-PAPPAPP--ESTVR 180
           PPP  PPAP    P  P       P   P   LC PP  P    P P+PP PP  E    
Sbjct: 403 PPPLTPPAPSPPPPLPP-------PSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEE 455

Query: 181 PAPPTRPGESS 191
             PP  P   S
Sbjct: 456 SPPPVVPATCS 466



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 32/112 (28%), Positives = 41/112 (36%), Gaps = 22/112 (19%)

Query: 122 PTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPA--------PPA 173
           P P PPPP  P S +P  P   P   P         +PP  P+P  PPA        PP 
Sbjct: 409 PAPSPPPPLPPPSTSPPPPLCPPPPPP--------VSPPPLPSPPPPPAQEEQEESPPPV 460

Query: 174 PPE--STVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRPGEATAASSE 223
            P   S  R  PP  P + +    +        + ++ P   P  AT    E
Sbjct: 461 VPATCSRKRGRPPLTPSQRAEREAARA----GPEGTSPPTPTPSTATGGPPE 508



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 41/156 (26%), Positives = 52/156 (33%), Gaps = 17/156 (10%)

Query: 68   QPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP-GLPTPPP 126
            +PVP PV  P P+ P + P   T      G                LG +   G+  P P
Sbjct: 2209 EPVPPPVKQP-PLPPTISPTAPTSWTLPPGP--------------LLGVLPVVGVVRPAP 2253

Query: 127  PPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTR 186
            PPPP P +       A P R+     R+   +  + PAP    AP    +       P  
Sbjct: 2254 PPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQV 2313

Query: 187  PGESSYSSISHVIYNNHQDSSASPRKRPGEATAASS 222
            PG  S    S V              RPGE     S
Sbjct: 2314 PGLGS-GGFSRVRMKTPTVRGVLDLDRPGEPAGEES 2348



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 30/97 (30%), Positives = 34/97 (35%), Gaps = 19/97 (19%)

Query: 110  RCFALGAVGPG---LPTPPPPPPPAPQSQ----------------APGGPEAQPFREPGL 150
            R FA     PG   L   P P PP P +                   G P   P ++P L
Sbjct: 2161 RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPL 2220

Query: 151  RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRP 187
             P I   AP +   P  P     P    VRPAPP  P
Sbjct: 2221 PPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPP 2257



 Score = 36.2 bits (82), Expect = 0.040
 Identities = 36/124 (29%), Positives = 47/124 (37%), Gaps = 31/124 (25%)

Query: 106  DARKRCFALGAVGPGLPTPPPPPP---------------PAPQSQAPGGPEAQPFREPGL 150
            DAR+RC+    +    P  P   P               PAP S+ PGG       +P L
Sbjct: 1769 DARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGG------EDPPL 1822

Query: 151  RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASP 210
               +L+   P R +P     PP  P+S    APP  P   S + I    Y        SP
Sbjct: 1823 DTDVLVPGAPERHSPIQNLDPPLRPDS--GSAPPPAPRSFSGARIKVPNY--------SP 1872

Query: 211  RKRP 214
             +RP
Sbjct: 1873 SRRP 1876



 Score = 35.4 bits (80), Expect = 0.068
 Identities = 43/141 (30%), Positives = 49/141 (34%), Gaps = 36/141 (25%)

Query: 79   PVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFAL--------GAVGPGLPTPPPPPPP 130
            P  P V   G    AG+R  +R PE   +    F L        G  GP   + PP PP 
Sbjct: 2085 PSGPGVVRAGVLGAAGDR--ARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPL 2142

Query: 131  APQSQAPGGPEAQPF----------REPGLRPRILLCAP-PARPAPS------------- 166
            A  SQ   G  A P             PG+R   L  AP P +PA S             
Sbjct: 2143 ANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFV 2202

Query: 167  --APPAPPAPPESTVRPAPPT 185
              A    P PP     P PPT
Sbjct: 2203 KMAGEGEPVPPPVKQPPLPPT 2223



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 39/144 (27%), Positives = 55/144 (38%), Gaps = 20/144 (13%)

Query: 61  RDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPE-VSDARKRCFALGAVGP 119
           R R  + +  P+P P    VAP  PP+      GE G  R  + +++  +R  A  A  P
Sbjct: 150 RGRGRKHKTTPLPPPRLADVAPT-PPKTPARKRGEEGTERMVQALTELLRRAQAPQA--P 206

Query: 120 GLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTV 179
                 P  P   + + PG P A P R    + + ++ A  A   P   P PP  P    
Sbjct: 207 RSRACEPSTPRRSRGRPPGRP-AGPCRR---KQQAVVVAEAAVTIPKPEPPPPVVPVKHQ 262

Query: 180 R------------PAPPTRPGESS 191
                        P  P R G+SS
Sbjct: 263 TGSWKCKEGPGPGPGTPRRGGQSS 286



 Score = 32.7 bits (73), Expect = 0.44
 Identities = 40/140 (28%), Positives = 55/140 (39%), Gaps = 15/140 (10%)

Query: 48   EAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDA 107
            + P    V   G  +R   +Q +  P+    P + + PP      +G R   + P  S +
Sbjct: 1819 DPPLDTDVLVPGAPERHSPIQNLDPPLR---PDSGSAPPPAPRSFSGAR--IKVPNYSPS 1873

Query: 108  RKRCFALGAVGPGLPTPPPPPPPAPQSQAP--GGPEAQPFREPGLRPRILLCAPPARPAP 165
            R+    LG V  G P P P  P +     P  G P+         RP  L  AP  RP P
Sbjct: 1874 RR---PLGGVSFG-PLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPL--AP--RPPP 1925

Query: 166  SAPPAPPAPPESTVRPAPPT 185
            S   +PP      +R  PPT
Sbjct: 1926 SRWASPPLKTSPQLRVPPPT 1945



 Score = 32.0 bits (71), Expect = 0.76
 Identities = 31/98 (31%), Positives = 36/98 (36%), Gaps = 21/98 (21%)

Query: 50  PEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARK 109
           PEPRAV       RT+ L        V  PV   V P G            AP +S+  +
Sbjct: 691 PEPRAVG------RTNHLSLPRFAPVVTTPVKAEVSPHG------------APALSNGPQ 732

Query: 110 RCFALGAVGPGLPT---PPPPPPPAPQSQAPGGPEAQP 144
               L      L T   P   PPP PQ Q P  P+  P
Sbjct: 733 TQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMP 770



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 36/152 (23%), Positives = 43/152 (28%), Gaps = 37/152 (24%)

Query: 69  PVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPP 128
           P+P P P P        P         R   R P     R    A  A     P    PP
Sbjct: 440 PLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAG----PEGTSPP 495

Query: 129 PPAPQSQAPGGPEAQPFREP-------GLR-----------------PRILLCAPPARP- 163
            P P +   G PE  P   P        +R                 PR  +   P +P 
Sbjct: 496 TPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPP 555

Query: 164 --------APSAPPAPPAPPESTVRPAPPTRP 187
                    P    +PP P E    P+PP  P
Sbjct: 556 KVEVSPVLRPPITTSPPVPQEPAPVPSPPRAP 587



 Score = 30.4 bits (67), Expect = 2.2
 Identities = 38/145 (26%), Positives = 49/145 (33%), Gaps = 37/145 (25%)

Query: 49   APEPRAVATNGLRDRTHRLQPVPVPV------PVPVPVAPA-----VPPRGGTDTAGERG 97
            AP P   + +G R +     P   P+      P+P P +P+     +P  G  D      
Sbjct: 1852 APPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPR 1911

Query: 98   GSRAPEVSDARKRCFALGAVGPGLPTPPP------PPPPAPQSQAPGGPEAQPFREPGLR 151
             SR P                P  P PPP      P   +PQ + P            L 
Sbjct: 1912 RSRRPS---------------PLAPRPPPSRWASPPLKTSPQLRVPPPTSVVT----ALT 1952

Query: 152  PRILLCAPPARPAPSAPPAPPAPPE 176
            P     APP  PAPS PP     P+
Sbjct: 1953 PTSGELAPPG-PAPSPPPPEDLGPD 1976


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 55/174 (31%), Positives = 66/174 (37%), Gaps = 31/174 (17%)

Query: 47  LEAPEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSD 106
           L  P P+A   N L    H LQ    P P P   AP  PP     +      S+AP    
Sbjct: 645 LATPSPQA--PNALA--VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 700

Query: 107 ARKRCF-----ALGAVGPGLPTPPPPPPP--APQSQAPGGPEAQPFREPGLRP--RI--L 155
           A          A   + P    PP  PPP  AP  Q P  P A P   P   P  R+  L
Sbjct: 701 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPL 760

Query: 156 LCAPP----------------ARPAPSAPPAPPAPPESTVRPAPPTRPGESSYS 193
           L APP                A+P P APPA   PP   +   P + PG++ +S
Sbjct: 761 LAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 814



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 37/139 (26%), Positives = 47/139 (33%), Gaps = 30/139 (21%)

Query: 49  APEPRAVATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDAR 108
           AP P   A+  L        P P P P+  P +P   P   T ++               
Sbjct: 542 APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSS--------------- 586

Query: 109 KRCFALGAVGPGLPTPPPPPPPA---PQSQAPGGPEAQPFREPGLRPRILLCAPPARPAP 165
                       + TPPP  PPA   P  Q    P   P   P  +    L  PP +  P
Sbjct: 587 ------------IATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPP 634

Query: 166 SAPPAPPAPPESTVRPAPP 184
           S P +PP  P +T  P  P
Sbjct: 635 SPPASPPLSPLATPSPQAP 653



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 34/98 (34%), Positives = 45/98 (45%), Gaps = 6/98 (6%)

Query: 100 RAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAP 159
           R P+V+  RK   A  A+GP   +P   P P+     P  P   P       P  L  +P
Sbjct: 281 RPPQVTPPRKD--AAPALGPLSSSPLATPSPSGTKARPVPP---PDNAATPLPATLPPSP 335

Query: 160 P-ARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSIS 196
           P A P P APP+P APP     P+PP  P   +  S++
Sbjct: 336 PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMT 373



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 44/138 (31%), Positives = 55/138 (39%), Gaps = 17/138 (12%)

Query: 73  PVPVPVPVAPAVPPRGGTDTAGERGGS--RAPEVSDARKRCFALGAVGPGLPTPPPPPPP 130
           P+ VP P  PA PP   + T   R      AP +        +L  + P L  PPP  PP
Sbjct: 734 PLQVP-PSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASL-PMSP-LAKPPPQAPP 790

Query: 131 A----PQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPP--------APPAPPEST 178
           A    P    P  P + P + P      L  +P A P P APP         PP+PP S 
Sbjct: 791 ALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASP 850

Query: 179 VRPAPPTRPGESSYSSIS 196
              AP   P     +S+S
Sbjct: 851 TLQAPRRPPTPGPDTSVS 868



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 36/132 (27%), Positives = 45/132 (34%), Gaps = 18/132 (13%)

Query: 70  VPVPVPVPVPVAPAVPPRGGTDTAGERGGS-------RAPEVSDARKRCFALGAVGPGLP 122
           +P P P   P  P   PR    +A E   +       R P      +R  +        P
Sbjct: 189 LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248

Query: 123 TPPP----------PPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPP 172
              P          P  PA  SQ P     Q  R P + P     AP   P  S+P A P
Sbjct: 249 LSSPARSGPSARGTPRAPAHPSQ-PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 307

Query: 173 APPESTVRPAPP 184
           +P  +  RP PP
Sbjct: 308 SPSGTKARPVPP 319



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 36/126 (28%), Positives = 47/126 (37%), Gaps = 29/126 (23%)

Query: 119 PGLPTPPPPPPPA--------------PQSQAPGG----------PEAQPFREPGLRPRI 154
           PG P PPPP  PA              P ++  GG          P A P R  G   R 
Sbjct: 30  PGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR- 88

Query: 155 LLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVIYNNHQDSSASPRKRP 214
               P +RP P++     APP     P P + PG +S ++    +       SA      
Sbjct: 89  ---NPASRP-PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR 144

Query: 215 GEATAA 220
           G+AT A
Sbjct: 145 GKATEA 150



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 50/179 (27%), Positives = 60/179 (33%), Gaps = 48/179 (26%)

Query: 67  LQPVPVPVPVPVPV-------APAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGP 119
           + P+  P P   PV        P  PP   T  A  R  +  P+ S +  R     A+ P
Sbjct: 821 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL--ALAP 878

Query: 120 GLPTPPPPPPPAPQSQAPG----------------------GPEAQPFREPGLRPRILLC 157
           G   PPPPP  +P S   G                      GPE      P     +  C
Sbjct: 879 G---PPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC 935

Query: 158 APPARPAPSAPP-----APPAPPESTVRPAPP-TRPGESSYSSISHVIYNNHQDSSASP 210
            P A     APP     AP AP      P PP T PG +        IY      SA+P
Sbjct: 936 HPAAWSRGPAPPLAFRGAPGAP-----LPWPPATGPGSADGLC---TIYETEGPESATP 986



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 35/116 (30%), Positives = 43/116 (37%), Gaps = 17/116 (14%)

Query: 71  PVPVPVPVPVAPAVPPRGGTDTAGER-GGSRAPEVSDARKRCFALGAVGPGLPTPPPPPP 129
           P   P     APA+ P   +  A     G++A  V         L A       PP PP 
Sbjct: 283 PQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPAT-----LPPSPPL 337

Query: 130 PAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPT 185
             P   AP  P A P  +        L +PPA P   APP+   PP      APP+
Sbjct: 338 ATPLPLAPPSPSAPPSLQT-------LPSPPATPPSQAPPSMTTPP----MQAPPS 382



 Score = 35.8 bits (81), Expect = 0.052
 Identities = 29/95 (30%), Positives = 37/95 (38%), Gaps = 18/95 (18%)

Query: 125 PPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAP-PESTV---- 179
           P  P   P  QAP    A   + P         +PPA P   AP  PP P P+++V    
Sbjct: 820 PMSPLATPPPQAPPVLAAPLLQVPP--------SPPASPTLQAPRRPPTPGPDTSVSGPR 871

Query: 180 -----RPAPPTRPGESSYSSISHVIYNNHQDSSAS 209
                 P PP  P  S  S++S      H  S+ S
Sbjct: 872 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS 906



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 48/198 (24%), Positives = 65/198 (32%), Gaps = 54/198 (27%)

Query: 68  QPVPVPVPVPVPV---APAVPPRGGTDTAGERGGSRAPEVS-----------DARKRCFA 113
           +P P   P  + V   A AV  +   + AG  GG+  PE +            +R     
Sbjct: 34  RPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASR 93

Query: 114 LGAVGPGLPTPPP----PPPPAPQSQAPGGPEAQPFREPGLR----------------PR 153
             A G G   PP     P P +   +A G     P  + GLR                 R
Sbjct: 94  PPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKR 153

Query: 154 ILLCAPPARPAPSAPPAPPAP-----------------PESTVRPAPPTRPGESSYSSIS 196
             L A   R      P  P+P                 P  + RP PPT     S SS S
Sbjct: 154 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS 213

Query: 197 HVIYNNHQDSSASPRKRP 214
               ++  + S + R+RP
Sbjct: 214 E---HSTTEPSPAARRRP 228



 Score = 32.0 bits (71), Expect = 0.76
 Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 14/118 (11%)

Query: 79  PVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPG 138
           P   A+      DT+G   G+ +P ++   +R  A G    GLP P P   P P ++ P 
Sbjct: 151 PKRSALSAGARRDTSGPTPGTPSPAMA---RRSRAAGTE-VGLPRPAPSARPRPPTEGPR 206

Query: 139 GPEAQPFREPGLRPRILLCAPPARPAPSA-----PPAPPAPPESTVRPAPPTRPGESS 191
              +         P     +P AR  PSA      PA  +   S    + P R G S+
Sbjct: 207 KSVSSASEHSTTEP-----SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSA 259



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 41/152 (26%), Positives = 48/152 (31%), Gaps = 30/152 (19%)

Query: 66   RLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPP 125
            RL     P P P P         G D AG    + +   +    R +  G  G    +PP
Sbjct: 871  RLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS---TPEELRGYDSGPEGGAAASPP 927

Query: 126  P---------------PPPPAPQSQAPGGPEAQPFREPGLRPRIL--LCA-------PPA 161
            P               P PP     APG P   P   P   P     LC          A
Sbjct: 928  PDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWP---PATGPGSADGLCTIYETEGPESA 984

Query: 162  RPAPSAPPAPPAPPESTVRPAPPTRPGESSYS 193
             PAP A    P+P  S  + A     G SS S
Sbjct: 985  TPAPGALDPGPSPGTSGGKAAAGAGAGASSRS 1016



 Score = 30.4 bits (67), Expect = 2.2
 Identities = 24/80 (30%), Positives = 28/80 (35%), Gaps = 7/80 (8%)

Query: 119 PGLPTPPPP--PPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAP----- 171
           P L TPP     PP     +   P  Q    P   P +     PA     APP+P     
Sbjct: 521 PSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPP 580

Query: 172 PAPPESTVRPAPPTRPGESS 191
           P  P S   P P   P  +S
Sbjct: 581 PETPSSIATPPPQAPPALAS 600



 Score = 28.9 bits (63), Expect = 6.4
 Identities = 29/129 (22%), Positives = 43/129 (33%), Gaps = 13/129 (10%)

Query: 69  PVPVPVPVP--------VPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPG 120
           P+P+  P P        +P  PA PP     +         P +              P 
Sbjct: 340 PLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPS 399

Query: 121 LPTPPPPPPPAP--QSQAPGGPEAQP---FREPGLRPRILLCAPPARPAPSAPPAPPAPP 175
           L  PP P   +    + + G P  Q    F     R        P+RPA + P +PP   
Sbjct: 400 LQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQA 459

Query: 176 ESTVRPAPP 184
             ++  +PP
Sbjct: 460 PLSLPASPP 468



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 37/135 (27%), Positives = 50/135 (37%), Gaps = 17/135 (12%)

Query: 70  VPVPVPVPVPVAPAVPPRGGTDT-----AGERGGSRAPEVSDARKRCFALGAVGPGLPTP 124
           +P   P+   ++PAV P     T     A     S +P+   +         + P L T 
Sbjct: 463 LPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLS-------SLIMPPLETQ 515

Query: 125 PPPPPPAPQSQAPGGPEAQPFRE-PGLRPRIL--LCAPPARPAPSAPPAPPAPPESTVRP 181
               PP+ Q+  P      P    P L P  L    AP   P    PP P AP      P
Sbjct: 516 SSLAPPSLQTP-PASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCP-APCPLQAPP 573

Query: 182 APPTRPGESSYSSIS 196
           +P T P   + SSI+
Sbjct: 574 SPLTTPPPETPSSIA 588


>gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3
           [Homo sapiens]
          Length = 1125

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 46/134 (34%), Positives = 54/134 (40%), Gaps = 15/134 (11%)

Query: 55  VATNGLRDRTHRLQPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFAL 114
           VA NG  + +H     P+P P+PVPV P   P   T           P+V   +     +
Sbjct: 641 VAQNGGAETSHTEPVSPIPKPLPVPVPPIPVPAPIT--------VPPPQVPPHQPGPPVV 692

Query: 115 GAVGPGLPTPP-PPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPA 173
           GA+ P   TPP   PPP      P  P   PF  PG  P  L    P    P  PP P  
Sbjct: 693 GALQPPAFTPPLGIPPPGFGPGVPPPPPPPPFLRPGFNPMHL----PPGFLPPGPPPPIT 748

Query: 174 PPESTVRPAPPTRP 187
           PP S   P P T P
Sbjct: 749 PPVSI--PPPHTPP 760



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 28/97 (28%), Positives = 35/97 (36%), Gaps = 24/97 (24%)

Query: 75  PVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQS 134
           P P P  P V P G     G   G   PE  D R++             PP  P   PQ 
Sbjct: 886 PFP-PHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQ-------------PPQQPQQQPQP 931

Query: 135 QAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAP 171
           QAP  P+ Q  ++P          PP++  P     P
Sbjct: 932 QAPQQPQQQQQQQP----------PPSQQPPPTQQQP 958



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 40/164 (24%), Positives = 48/164 (29%), Gaps = 53/164 (32%)

Query: 70  VPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGL-------- 121
           VP   P  +P  P   P       G +G +  P +         LGA  PGL        
Sbjct: 787 VPPAAPTNLPTPPVTQP---VSLLGTQGVAPGPVIGLQAPSTGLLGA-RPGLIPLQRPPG 842

Query: 122 -------------PTPPPP------PPPAPQSQA------------PGGPEAQPFREPGL 150
                        P P PP      PPP P   A            P GP  +P   PGL
Sbjct: 843 MPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGL 902

Query: 151 ----------RPRILLCAPPARPAPSAPPAPPAPPESTVRPAPP 184
                       R     PP +P     P  P  P+   +  PP
Sbjct: 903 GGPGPGPGGPEDRDGRQQPPQQPQQQPQPQAPQQPQQQQQQQPP 946



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 41/201 (20%), Positives = 66/201 (32%), Gaps = 60/201 (29%)

Query: 102 PEVSDARKR--CFALGAVGPGLPTPPPPPPPAPQSQAPGG----PEAQPFREPG------ 149
           PE  +  K+    A+    P    PP P    P + AP      P   PF  PG      
Sbjct: 271 PEAVEESKKEDTTAVTTTAPAAAVPPAPTATVPAAAAPAAASPPPPQAPFGFPGDGMQQP 330

Query: 150 ----------LRPRIL----------LCAPP--ARPAPSAPPAPPAPP--ESTVRPAPPT 185
                      +PR++          +  PP    P     P PP PP  +  + P PP 
Sbjct: 331 AYTQHQNMDQFQPRMMGIQQDPMHHQVPLPPNGQMPGFGLLPTPPFPPMAQPVIPPTPPV 390

Query: 186 -RPGESSYSS-----------------------ISHVIYNNHQDSSASPRKRPGEATAAS 221
            +P ++S+ +                       +   + +N +  S S  + P    + S
Sbjct: 391 QQPFQASFQAQNEPLTQKPHQQEMEVEQPCIQEVKRHMSDNRKSRSRSASRSPKRRRSRS 450

Query: 222 SEIKALQQTRRLLANARERTR 242
                  + RR  + +R+R R
Sbjct: 451 GSRSRRSRHRRSRSRSRDRRR 471



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 24/88 (27%), Positives = 31/88 (35%), Gaps = 24/88 (27%)

Query: 118 GPGLPTPPPP-------PPPAP------------QSQAPGGPE-----AQPFREPGLRPR 153
           GPG    PPP       PP  P                PGGPE      QP ++P  +P+
Sbjct: 871 GPGGFAMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGGPEDRDGRQQPPQQPQQQPQ 930

Query: 154 ILLCAPPARPAPSAPPAPPAPPESTVRP 181
                 P +     PP    PP +  +P
Sbjct: 931 PQAPQQPQQQQQQQPPPSQQPPPTQQQP 958


>gi|118498339 EMI domain containing 2 [Homo sapiens]
          Length = 439

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 65/234 (27%), Positives = 81/234 (34%), Gaps = 54/234 (23%)

Query: 46  DLEAPEPRAVATNG--LRDRTHRLQPVPV---------PVPVPVPVAPAVPP--RGGTDT 92
           DL APE      N   L D      PVP          P     P  PA PP  +G    
Sbjct: 163 DLPAPESTPPTWNEDFLPDAIPLAHPVPRQRRPTGPAGPPGQTGPPGPAGPPGSKGDRGQ 222

Query: 93  AGERGGSRAPEVSDARKRCFALGAVGP-------GLPTPPPPPPPA----PQSQAPGG-- 139
            GE+G +  P +         LG  GP       G P PP PP PA    P   +P G  
Sbjct: 223 TGEKGPAGPPGL---------LGPPGPRGLPGEMGRPGPPGPPGPAGNPGPSPNSPQGAL 273

Query: 140 -----PEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSS 194
                P  +   +  L   I+       P P  PP PP PP     P PP  PG    + 
Sbjct: 274 YSLQPPTDKDNGDSRLASAIVDTVLAGVPGPRGPPGPPGPPGPRGPPGPPGTPGSQGLAG 333

Query: 195 ISHVIYNNHQDSSASPRKRPG-----EATAASSEIKALQQTRRLLANARERTRV 243
                    +  +  P   PG        AA++E + +QQ R  L    ER  +
Sbjct: 334 ---------ERGTVGPSGEPGVKGEEGEKAATAEGEGVQQLREALKILAERVLI 378


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 58/197 (29%), Positives = 70/197 (35%), Gaps = 32/197 (16%)

Query: 68  QPVPVPVPVPVPVAPAVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPP 127
           Q  P P P   P  P +PP    +    R   R   +S +     + G  GP LP PP  
Sbjct: 305 QAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP-LPPPPSE 363

Query: 128 PPPAPQSQAPGG----PEAQPFREPGLRPRILLCAP--PAR---PAPSAPPAPPAPPEST 178
            PP P    PG     P   P    G   R L   P  P+R    +P + P PP PP+  
Sbjct: 364 RPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP 423

Query: 179 VRPAPPTRPGESSYSSISHVIYNNHQDS---------------SASPRKRPGEATAASSE 223
              APP  P  +S       I N  QDS               S  P   P   T  S  
Sbjct: 424 SAGAPPPPPPSTS-------IRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYP 476

Query: 224 IKALQQTRRLLANARER 240
            K  +   R  +N RER
Sbjct: 477 SKLARNESRSGSNRRER 493



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 53/182 (29%), Positives = 66/182 (36%), Gaps = 25/182 (13%)

Query: 50  PEPRAVATNGLRDRTHRLQPVPVP----VPVPVPVAPAVPPRGGTDTAGERGGSRAPEVS 105
           P P       ++   H     PVP     P P P  P  P   GT   G  G  R   +S
Sbjct: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGG--GSIRQSPLS 241

Query: 106 DARKRCFALGAVGPGLPTP-------PPPPPPAPQSQAPGGPEAQPFREP-GLRPRILLC 157
            +           P  PTP       PPPPPP   ++     EA P   P   +P +   
Sbjct: 242 SSSP----FSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPV--- 294

Query: 158 APPARPAPSAPPAPPAPPESTVRPAPPTRPGESSYSSISHVI--YNNHQDSSASPRKRPG 215
             P+ P PSA    P PP    RP PP  P  SS +  +  +   N    SS  P   PG
Sbjct: 295 --PSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPG 352

Query: 216 EA 217
            +
Sbjct: 353 RS 354



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 46/151 (30%), Positives = 55/151 (36%), Gaps = 21/151 (13%)

Query: 67  LQPVPVPVPVPVPVAP-----AVPPRGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGL 121
           L   P P P PV   P     AVPP    +       ++ P  S  R    +     P  
Sbjct: 260 LDDKPPPPPPPVGNRPSIHREAVPPPPPQN-------NKPPVPSTPRPSASSQAPPPPPP 312

Query: 122 PTPPPPPPPAPQSQAPGGPEAQPFREPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRP 181
           P+ P PPP  P S   G  E      P L  R L  +    P PS   + P PP  + RP
Sbjct: 313 PSRPGPPPLPPSSS--GNDET-----PRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERP 365

Query: 182 APPTR--PGESSYSSISHVIYNNHQDSSASP 210
            PP R  PG S        +  N   S A P
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 13/95 (13%)

Query: 87  RGGTDTAGERGGSRAPEVSDARKRCFALGAVGPGLPTPPPPPPPAPQSQAPGGPEAQPFR 146
           R   +   + GGSR P +    +   A     P  P   P P P  +S   G PE Q  R
Sbjct: 112 RSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRS---GPPEPQRNR 168

Query: 147 EPGLRPRILLCAPPARPAPSAPPAPPAPPESTVRP 181
            P          PP     S P + P P  ST RP
Sbjct: 169 MP----------PPRPDVGSKPDSIPPPVPSTPRP 193


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,765,526
Number of Sequences: 37866
Number of extensions: 1356046
Number of successful extensions: 43560
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1068
Number of HSP's successfully gapped in prelim test: 1807
Number of HSP's that attempted gapping in prelim test: 11762
Number of HSP's gapped (non-prelim): 15064
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.