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Search of human proteins with 22547180
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22547180 transient receptor potential cation channel,
subfamily V, member 4 isoform b [Homo sapiens]
(811 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22547180 transient receptor potential cation channel, subfami... 1649 0.0
gi|22547184 transient receptor potential cation channel, subfami... 874 0.0
gi|20127551 transient receptor potential cation channel, subfami... 443 e-124
gi|21735483 transient receptor potential cation channel, subfami... 420 e-117
gi|74315354 transient receptor potential cation channel, subfami... 372 e-102
gi|74315352 transient receptor potential cation channel, subfami... 372 e-102
gi|74315350 transient receptor potential cation channel, subfami... 372 e-102
gi|74315348 transient receptor potential cation channel, subfami... 372 e-102
gi|21314682 transient receptor potential cation channel, subfami... 208 2e-53
gi|17505200 transient receptor potential cation channel, subfami... 206 5e-53
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 61 5e-09
gi|11225266 transient receptor potential cation channel, subfami... 51 4e-06
gi|4507689 transient receptor potential cation channel, subfamil... 48 4e-05
gi|109689695 transient receptor potential cation channel, subfam... 47 7e-05
gi|55770876 notch4 preproprotein [Homo sapiens] 41 0.004
gi|9966865 transient receptor potential cation channel, subfamil... 41 0.004
gi|169216484 PREDICTED: similar to transient receptor potential ... 41 0.005
gi|194733735 transient receptor potential cation channel, subfam... 39 0.019
gi|4507687 transient receptor potential cation channel, subfamil... 39 0.019
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 39 0.025
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 39 0.025
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 39 0.025
gi|5730102 transient receptor potential cation channel, subfamil... 38 0.033
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 38 0.043
gi|6912736 transient receptor potential cation channel, subfamil... 37 0.056
gi|209863032 transient receptor potential cation channel, subfam... 37 0.056
gi|209863030 transient receptor potential cation channel, subfam... 37 0.056
gi|209863026 transient receptor potential cation channel, subfam... 37 0.056
gi|209863024 transient receptor potential cation channel, subfam... 37 0.056
gi|7706747 transient receptor potential cation channel, subfamil... 37 0.056
>gi|22547180 transient receptor potential cation channel, subfamily
V, member 4 isoform b [Homo sapiens]
Length = 811
Score = 1649 bits (4269), Expect = 0.0
Identities = 811/811 (100%), Positives = 811/811 (100%)
Query: 1 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP 60
MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
Sbjct: 1 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP 60
Query: 61 GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN 120
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
Sbjct: 61 GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN 120
Query: 121 KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL 180
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
Sbjct: 121 KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL 180
Query: 181 TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT 240
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
Sbjct: 181 TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT 240
Query: 241 ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI 300
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
Sbjct: 241 ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI 300
Query: 301 VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS 360
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
Sbjct: 301 VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS 360
Query: 361 NLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC 420
NLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
Sbjct: 361 NLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC 420
Query: 421 AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV 480
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
Sbjct: 421 AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV 480
Query: 481 NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG 540
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
Sbjct: 481 NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG 540
Query: 541 TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC 600
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
Sbjct: 541 TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC 600
Query: 601 RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE 660
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
Sbjct: 601 RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE 660
Query: 661 TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV 720
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
Sbjct: 661 TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV 720
Query: 721 DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE 780
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
Sbjct: 721 DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE 780
Query: 781 VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL 811
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
Sbjct: 781 VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL 811
>gi|22547184 transient receptor potential cation channel, subfamily
V, member 4 isoform a [Homo sapiens]
Length = 871
Score = 874 bits (2258), Expect = 0.0
Identities = 431/440 (97%), Positives = 432/440 (98%)
Query: 372 SPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYY 431
S L + KI NRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYY
Sbjct: 432 SVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYY 491
Query: 432 QPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQL 491
QPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQL
Sbjct: 492 QPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQL 551
Query: 492 LYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILF 551
LYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILF
Sbjct: 552 LYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILF 611
Query: 552 KDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLL 611
KDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLL
Sbjct: 612 KDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLL 671
Query: 612 DLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKH 671
DLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKH
Sbjct: 672 DLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKH 731
Query: 672 IWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQN 731
IWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQN
Sbjct: 732 IWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQN 791
Query: 732 LGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNP 791
LGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNP
Sbjct: 792 LGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDEVVVPLDSMGNP 851
Query: 792 RCDGHQQGYPRKWRTDDAPL 811
RCDGHQQGYPRKWRTDDAPL
Sbjct: 852 RCDGHQQGYPRKWRTDDAPL 871
Score = 786 bits (2031), Expect = 0.0
Identities = 390/406 (96%), Positives = 393/406 (96%)
Query: 1 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP 60
MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
Sbjct: 1 MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP 60
Query: 61 GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN 120
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
Sbjct: 61 GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN 120
Query: 121 KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL 180
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
Sbjct: 121 KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL 180
Query: 181 TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT 240
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
Sbjct: 181 TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT 240
Query: 241 ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI 300
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
Sbjct: 241 ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI 300
Query: 301 VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS 360
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
Sbjct: 301 VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS 360
Query: 361 NLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWRKF 406
NLEAVLNNDGLSPLMMAAKTGKIG ++ E +E R RKF
Sbjct: 361 NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKF 406
>gi|20127551 transient receptor potential cation channel, subfamily
V, member 2 [Homo sapiens]
Length = 764
Score = 443 bits (1139), Expect = e-124
Identities = 275/666 (41%), Positives = 374/666 (56%), Gaps = 71/666 (10%)
Query: 139 APQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKA 198
A QP P F+R LF+ VSRG DL GL +L K LTD E+ E STGKTCL KA
Sbjct: 66 ASQPDP--NRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKA 123
Query: 199 LLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLV 258
+LNL +G N I LL I +GN + +N+ D YYRG +ALHIAIE+R V+LLV
Sbjct: 124 VLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV 183
Query: 259 AQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQD 318
GA+VHA+A GRFFQ K +G FYFGELPLSLAACT Q +V+YL ENPH+ A ++ D
Sbjct: 184 ENGANVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATD 242
Query: 319 SRGNTVLHALVAIADNTRENTKFVTKMY-----------------------DLLLLKCA- 354
S+GNTVLHALV I+DN+ EN VT MY DL LK A
Sbjct: 243 SQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAA 302
Query: 355 -----------------------RLFPD----------SNLEAVLNNDGLSPLMMAAKTG 381
R F + +L +V + + S L + A
Sbjct: 303 KEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC 362
Query: 382 KIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPL--EGTPP 439
K +RH M+ +EP+N+LL+ KW F++N + L M IFT AY+QP + P
Sbjct: 363 KSPHRHRMVVLEPLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAP 421
Query: 440 YPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVL 499
+ + + L G ++ L G+ + F ++ + FID F++L+ ++L
Sbjct: 422 HLKAEVGNSMLLTGHILILLGGIYLLVGQLW-YFWRRHVFIWISFIDSYFEILFLFQALL 480
Query: 500 VIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLL 559
+VS L IE YL ++V ALVLGW+N LY+TRG + TG YS+MIQK++ +DL RFLL
Sbjct: 481 TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL 540
Query: 560 VYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTF------LLDL 613
+YL+F+ G+A ALVSL + +V D + + L+L
Sbjct: 541 IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL 600
Query: 614 FKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIW 673
FK TIGMG+L + + ++LL+ Y++LT++LLLNMLIALM ETV V+ +S IW
Sbjct: 601 FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
Query: 674 KLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLG 733
KLQ A ++L++E + + RK R+G M+TVG DG+PD RWCFRV+EVNW+ W Q L
Sbjct: 661 KLQKAISVLEMENGY-WWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLP 719
Query: 734 IINEDP 739
+ EDP
Sbjct: 720 TLCEDP 725
>gi|21735483 transient receptor potential cation channel, subfamily
V, member 3 [Homo sapiens]
Length = 790
Score = 420 bits (1079), Expect = e-117
Identities = 259/653 (39%), Positives = 362/653 (55%), Gaps = 87/653 (13%)
Query: 154 LFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFRE--------PSTGKTCLPKALLNLSNG 205
+F VS G +L LL L +R DE+ + TGKTCL KALLN++
Sbjct: 123 IFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPN 182
Query: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
+ + +LL AE + FIN+ + + Y GQTAL+IAIERR LL+A GADV+
Sbjct: 183 TKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVN 242
Query: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
A A+G FF PK + FYFGE PL+LAACTNQP IV L E H++ D+ +DSRGN +L
Sbjct: 243 AHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLME--HEQTDITSRDSRGNNIL 300
Query: 326 HALVAIADN--------------------------TRENT-----KFVTKMYDLLLLK-- 352
HALV +A++ TR N + KM +LK
Sbjct: 301 HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI 360
Query: 353 ------------CARLFPD-------SNLEAVLNNDGL---SPLMMAAKTGKIGNRHEML 390
+R F D S+L + N D S L + I NRHEML
Sbjct: 361 LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML 420
Query: 391 AVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTP-PYPYRTT--VD 447
+EP++ LL KW+KF F+++ Y + TL +YY+P E P+P T +
Sbjct: 421 TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG 480
Query: 448 YLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALY 507
+L+L G + L + +F+ + + S+ D F ++FI +VLVI+S LY
Sbjct: 481 WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY 540
Query: 508 LAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIG 567
L + YLA +V A+ LGW N LY+TRG + G YS+MIQK++ D+ +FL VY++F++G
Sbjct: 541 LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG 600
Query: 568 YASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLS 627
+ AL SL+ C +D +C+ +Y S FS +L+LFKLTIG+GDL +
Sbjct: 601 FGVALASLIEKCP------KDNKDCS--SYGS------FSDAVLELFKLTIGLGDLNIQQ 646
Query: 628 STKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERS 687
++KYP++F+ LL+TY+ILTFVLLLNMLIALMGETV VSKES+ IW+LQ A TIL+ E+
Sbjct: 647 NSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKM 706
Query: 688 FPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPG 740
P +LR FR GE+ V + D R C R++EV W+ W ++ +NEDPG
Sbjct: 707 LPEWLRSRFRMGELCKVAED-----DFRLCLRINEVKWTEWKTHVSFLNEDPG 754
>gi|74315354 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 372 bits (954), Expect = e-102
Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%)
Query: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266
N + L+++A+ T + +F+ S + +I + GA +H
Sbjct: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322
Query: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326
+ K G PL+LAA T + ++ Y+ + ++ + R + +
Sbjct: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375
Query: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386
V + +YDL + +S LE + + +P NR
Sbjct: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410
Query: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446
H+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ T
Sbjct: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470
Query: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506
DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + L
Sbjct: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
Query: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566
Y + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F+
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
Query: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622
G+++A+V+L+ N + +E ++ P+CR ++ L L+LFK TIGMGD
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647
Query: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682
LE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL
Sbjct: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707
Query: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742
D E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG
Sbjct: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767
Query: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781
E + FS R+ W ++VP + E + +++ P+EV
Sbjct: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
Score = 256 bits (653), Expect = 8e-68
Identities = 137/261 (52%), Positives = 179/261 (68%)
Query: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205
L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
Query: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
+N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV
Sbjct: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
Query: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL
Sbjct: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
Query: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385
HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG
Sbjct: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
Query: 386 RHEMLAVEPINELLRDKWRKF 406
+L E R RKF
Sbjct: 350 LAYILQREIQEPECRHLSRKF 370
>gi|74315352 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 372 bits (954), Expect = e-102
Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%)
Query: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266
N + L+++A+ T + +F+ S + +I + GA +H
Sbjct: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322
Query: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326
+ K G PL+LAA T + ++ Y+ + ++ + R + +
Sbjct: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375
Query: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386
V + +YDL + +S LE + + +P NR
Sbjct: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410
Query: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446
H+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ T
Sbjct: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470
Query: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506
DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + L
Sbjct: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
Query: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566
Y + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F+
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
Query: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622
G+++A+V+L+ N + +E ++ P+CR ++ L L+LFK TIGMGD
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647
Query: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682
LE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL
Sbjct: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707
Query: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742
D E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG
Sbjct: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767
Query: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781
E + FS R+ W ++VP + E + +++ P+EV
Sbjct: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
Score = 256 bits (653), Expect = 8e-68
Identities = 137/261 (52%), Positives = 179/261 (68%)
Query: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205
L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
Query: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
+N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV
Sbjct: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
Query: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL
Sbjct: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
Query: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385
HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG
Sbjct: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
Query: 386 RHEMLAVEPINELLRDKWRKF 406
+L E R RKF
Sbjct: 350 LAYILQREIQEPECRHLSRKF 370
>gi|74315350 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 372 bits (954), Expect = e-102
Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%)
Query: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266
N + L+++A+ T + +F+ S + +I + GA +H
Sbjct: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322
Query: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326
+ K G PL+LAA T + ++ Y+ + ++ + R + +
Sbjct: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375
Query: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386
V + +YDL + +S LE + + +P NR
Sbjct: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410
Query: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446
H+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ T
Sbjct: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470
Query: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506
DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + L
Sbjct: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
Query: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566
Y + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F+
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
Query: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622
G+++A+V+L+ N + +E ++ P+CR ++ L L+LFK TIGMGD
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647
Query: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682
LE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL
Sbjct: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707
Query: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742
D E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG
Sbjct: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767
Query: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781
E + FS R+ W ++VP + E + +++ P+EV
Sbjct: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
Score = 256 bits (653), Expect = 8e-68
Identities = 137/261 (52%), Positives = 179/261 (68%)
Query: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205
L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
Query: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
+N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV
Sbjct: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
Query: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL
Sbjct: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
Query: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385
HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG
Sbjct: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
Query: 386 RHEMLAVEPINELLRDKWRKF 406
+L E R RKF
Sbjct: 350 LAYILQREIQEPECRHLSRKF 370
>gi|74315348 transient receptor potential cation channel, subfamily
V, member 1 [Homo sapiens]
Length = 839
Score = 372 bits (954), Expect = e-102
Identities = 214/586 (36%), Positives = 336/586 (57%), Gaps = 69/586 (11%)
Query: 207 NDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHA 266
N + L+++A+ T + +F+ S + +I + GA +H
Sbjct: 286 NTVLHALVEVADNTADNTKFVTSMYNEI-----------------------LMLGAKLHP 322
Query: 267 QARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLH 326
+ K G PL+LAA T + ++ Y+ + ++ + R + +
Sbjct: 323 TLKLEELTNKK-------GMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY 375
Query: 327 ALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNR 386
V + +YDL + +S LE + + +P NR
Sbjct: 376 GPVH------------SSLYDLSCIDTCE--KNSVLEVIAYSSSETP-----------NR 410
Query: 387 HEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTV 446
H+ML VEP+N LL+DKW +F FY N + Y M+IFT+ AYY+P++G PP+ T
Sbjct: 411 HDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTG 470
Query: 447 DYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAAL 506
DY R+ GE++++ GV FFF I+ F+++ P + +LF+D ++L+F+ S+ ++ + L
Sbjct: 471 DYFRVTGEILSVLGGVYFFFRGIQ-YFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529
Query: 507 YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMI 566
Y + ++ Y+A MVF+L LGW N LY+TRG + G Y++MI+K++ +DL RF+ VY++F+
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589
Query: 567 GYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL----LDLFKLTIGMGD 622
G+++A+V+L+ N + +E ++ P+CR ++ L L+LFK TIGMGD
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRW--RGPACRPPDSSYNSLYSTCLELFKFTIGMGD 647
Query: 623 LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTIL 682
LE + + VFIILL+ Y+ILT++LLLNMLIALMGETV ++++ESK+IWKLQ A TIL
Sbjct: 648 LEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITIL 707
Query: 683 DIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKN 742
D E+SF +RKAFRSG+++ VG + DG D RWCFRVDEVNW+ WN N+GIINEDPG
Sbjct: 708 DTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNC 767
Query: 743 E-TYQYYGFSHTVGRLRRDRWS--SVVPRVVELN----KNSNPDEV 781
E + FS R+ W ++VP + E + +++ P+EV
Sbjct: 768 EGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEV 813
Score = 256 bits (653), Expect = 8e-68
Identities = 137/261 (52%), Positives = 179/261 (68%)
Query: 146 LKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNG 205
L++++R +F+ V++ + DL+ LL FL KK LTD EF++P TGKTCL KA+LNL +G
Sbjct: 110 LRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDG 169
Query: 206 RNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVH 265
+N TIP+LL+IA +T +++E +N+ + D YY+GQTALHIAIERR V LLV GADV
Sbjct: 170 QNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQ 229
Query: 266 AQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVL 325
A A G FF+ FYFGELPLSLAACTNQ IV +L +N + AD+ +DS GNTVL
Sbjct: 230 AAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVL 289
Query: 326 HALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGN 385
HALV +ADNT +NTKFVT MY+ +L+ A+L P LE + N G++PL +AA TGKIG
Sbjct: 290 HALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGV 349
Query: 386 RHEMLAVEPINELLRDKWRKF 406
+L E R RKF
Sbjct: 350 LAYILQREIQEPECRHLSRKF 370
>gi|21314682 transient receptor potential cation channel, subfamily
V, member 6 [Homo sapiens]
Length = 725
Score = 208 bits (529), Expect = 2e-53
Identities = 161/534 (30%), Positives = 241/534 (45%), Gaps = 97/534 (18%)
Query: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284
E + P Y GQTALHIA+ + + V L+A+ A V A+A G F+ + YF
Sbjct: 104 ELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFR-RSPCNLIYF 162
Query: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344
GE PLS AAC N IV L E+ AD+R QDS GNTVLH L+ + N F +
Sbjct: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214
Query: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTG----------------------- 381
MY+LLL L+ V N+ GL+P +A G
Sbjct: 215 MYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLT 274
Query: 382 -------------------------KIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVV 416
K ++L P+ EL+ KW+++G F +
Sbjct: 275 STLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGA 334
Query: 417 SYLCAMVIFTLTAYYQPLEG-----TPPYP------------YRTTVDYLRLAGEVITLF 459
YL ++ FT+ Y+PL+ T P Y T D +RL GE++T+
Sbjct: 335 IYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVI 394
Query: 460 TGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVSAALYLAGIEAYL 515
++ + D+F GV F + G F +L Y+ +V+V+ + L +
Sbjct: 395 GAIIILLVEVPDIFRM---GVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEV 451
Query: 516 AVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSL 575
M FALVLGW N +YF RG ++ G ++IMIQK++F DL RF + + ++G+ASA +
Sbjct: 452 VPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYII 511
Query: 576 LNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF 635
+ + YP FSTF +LF LTI G + P ++
Sbjct: 512 FQ-------TEDPEELGHFYDYPMA----LFSTF--ELF-LTIIDGPANY--NVDLPFMY 555
Query: 636 IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFP 689
I + I+ +L+LN+LIA+MG+T +V+ E +W+ Q T + +ER P
Sbjct: 556 SITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLP 609
>gi|17505200 transient receptor potential cation channel, subfamily
V, member 5 [Homo sapiens]
Length = 729
Score = 206 bits (525), Expect = 5e-53
Identities = 169/569 (29%), Positives = 250/569 (43%), Gaps = 104/569 (18%)
Query: 225 EFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYF 284
E + P + GQTALHIA+ + + V L+ + A V A+A G F+ + YF
Sbjct: 104 ELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFR-RSPRNLIYF 162
Query: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344
GE PLS AAC N IV L E+ AD+R QDS GNTVLH L+ + N F +
Sbjct: 163 GEHPLSFAACVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQ 214
Query: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKI--------GNRH--------- 387
MY+LLL L+ V N+ GL+P +A G RH
Sbjct: 215 MYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLT 274
Query: 388 -------------------------------EMLAVEPINELLRDKWRKFGAVSFYINVV 416
++L P+ EL+ KW K+G F I
Sbjct: 275 SILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAA 334
Query: 417 SYLCAMVIFTLTAYYQPLE---GTPPYP--------------YRTTVDYLRLAGEVITLF 459
YL M+ FT Y+PL+ G + Y T D +RL GE++++
Sbjct: 335 LYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIV 394
Query: 460 TGVLFFFTNIKDLFMKKCPGVNSLF----IDGSFQLLYFIYSVLVIVSAALYLAGIEAYL 515
V+ I D+F G + F + G F ++ Y+ LV+V+ + L +
Sbjct: 395 GAVIILLLEIPDIFRV---GASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEV 451
Query: 516 AVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSL 575
M FALVLGW + +YFTRG ++ G ++IMIQK++F DL RF + + ++G+ASA +
Sbjct: 452 VPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYII 511
Query: 576 LNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF 635
ED T S + L F+L + + D P +F
Sbjct: 512 FQ--------TEDPT--------SLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMF 555
Query: 636 IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKA 695
I+ + I+ +L+LN+ IA+MG+T +V++E +W+ Q T + +ER P L
Sbjct: 556 SIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWP- 614
Query: 696 FRSGEMVTVGKSSDGTPDRRWCFRVDEVN 724
RSG + G D RW RV+ N
Sbjct: 615 -RSG----ICGCEFGLGD-RWFLRVENHN 637
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 60.8 bits (146), Expect = 5e-09
Identities = 80/344 (23%), Positives = 145/344 (42%), Gaps = 41/344 (11%)
Query: 385 NRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFT-LTAYYQP---------L 434
NR E+L E L KW +G + +N+ SY ++ T L +P +
Sbjct: 693 NRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGII 752
Query: 435 EGTPPYP--YRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLL 492
T + TT YL ++ + + + +F +K + F+D S L
Sbjct: 753 NETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQK----RNYFMDISNVLE 808
Query: 493 YFIYSVLVIVSAALYLAGIEAYLAVM--VFALVLGWMNALYFTRGLKLTGTYSIMIQKIL 550
+ IY+ +I L++ I A+L A+ WMN L + + + G + +M++ IL
Sbjct: 809 WIIYTTGIIFVLPLFVE-IPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVIL 867
Query: 551 FKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFL 610
K L R +V++ ++ + + LLN +D + P +TFS L
Sbjct: 868 -KTLLRSTVVFIFLLLAFGLSFYILLNL--------QDPFSS-----PLLSIIQTFSMML 913
Query: 611 LDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESK 670
D+ + + + +PV+ LV++ I ++L+N+LI L VG +++ K
Sbjct: 914 GDI-NYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGL---AVGDIAEVQK 969
Query: 671 HIWKLQWATTI---LDIERSFPV-FLRKAFRSGEMVTVGKSSDG 710
H + A + +E+ P+ FLRK + +V K G
Sbjct: 970 HASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSG 1013
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 51.2 bits (121), Expect = 4e-06
Identities = 69/297 (23%), Positives = 126/297 (42%), Gaps = 25/297 (8%)
Query: 399 LRDKWRKFGAVS---FYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEV 455
L +WRKF F NVV Y + +FT Y L P P + + L V
Sbjct: 720 LLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWV 775
Query: 456 ITLFTGVLF--FFTNIKDLFMKKCPGVNSLFIDGSFQL--LYFIYSVLVIVSAALYLAGI 511
TL + FFT+ +KK +L++ ++ + I+ +V V+ + +
Sbjct: 776 FTLVLEEIRQGFFTDEDTHLVKKF----TLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAF 831
Query: 512 EAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASA 571
EA V+ ++ + ++ K G I++++++ KD+F FL ++++ Y
Sbjct: 832 EAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVT 890
Query: 572 LVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKY 631
+LL+P + V P + +D ++ L + S
Sbjct: 891 TQALLHPHDGRL----EWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSC 946
Query: 632 PVVF-----IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 683
P ++ I+LLVT++++T VLL+N+LIA+ T V + WK Q I++
Sbjct: 947 PSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVE 1003
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 47.8 bits (112), Expect = 4e-05
Identities = 70/288 (24%), Positives = 117/288 (40%), Gaps = 38/288 (13%)
Query: 409 VSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTN 468
V F++N++SY + +F AY ++ P + YL L V + F+
Sbjct: 797 VVFHLNILSYFAFLCLF---AYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQL--FYDP 851
Query: 469 IKDLFMKKCPGVNSLF---IDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLG 525
+ MKK S F +D LL+ ++ A LY + L ++F L L
Sbjct: 852 DECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLM 911
Query: 526 WMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVC 585
+ + T G K I+I K + KD+F FL + ++++ + A ++L +
Sbjct: 912 HIFTISKTLGPK------IIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAIL-------IH 958
Query: 586 NEDQTN-----CTVPTY-------PSCRDSETF-----STFLLDLFKLTIGMGDLEMLSS 628
NE + + +Y P D F S D +K D
Sbjct: 959 NERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRP 1018
Query: 629 TKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQ 676
+ ++LL Y++ T +LLLN+LIA+ T QV + + IWK Q
Sbjct: 1019 AFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQ 1066
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 47.0 bits (110), Expect = 7e-05
Identities = 66/287 (22%), Positives = 128/287 (44%), Gaps = 44/287 (15%)
Query: 409 VSFYINVVSYLCAMVIFTLTAYYQPLE----GTPPYPYRTTVDYLRLAGEVITLFTGVLF 464
V F NVV Y+ +++F AY ++ PP ++ ++ EV + +
Sbjct: 736 VVFSWNVVFYIAFLLLF---AYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVN 792
Query: 465 FFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVLVIV----SAALYLAGIEAYLAVMVF 520
+FT++ ++ + L YFI ++ + ++LY + L ++F
Sbjct: 793 YFTDLWNVM-------------DTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIF 839
Query: 521 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 580
L L ++ +R L G IM+Q++L D+F FL ++ ++M+ + A +L
Sbjct: 840 TLRL--IHIFTVSRNL---GPKIIMLQRMLI-DVFFFLFLFAVWMVAFGVARQGILRQNE 893
Query: 581 N-----MKVCNEDQTNCTVPTYPSCRDSETFS----TFLLDLFK-LTIGMGDLEMLSSTK 630
+ + PS D T+ TF + K L + +L+ + +
Sbjct: 894 QRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCV---ELDEHNLPR 950
Query: 631 YPV-VFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQ 676
+P + I L+ Y++ T +LL+N+L+A+ G TVG V + + +WK Q
Sbjct: 951 FPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQ 997
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/121 (33%), Positives = 57/121 (47%), Gaps = 19/121 (15%)
Query: 285 GELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTK 344
GE PL LAA ++P L E A+ + D G T LHA A+A + RE +
Sbjct: 1634 GETPLHLAARFSRPTAARRLLE---AGANPNQPDRAGRTPLHA--AVAADAREVCQ---- 1684
Query: 345 MYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAKTGKIGNRHEMLAVEPINELLRDKWR 404
LLL+ + D+ E DG +PLM+AA+ E++A + + RDKW
Sbjct: 1685 ----LLLRSRQTAVDARTE-----DGTTPLMLAARLAVEDLVEELIAAQ-ADVGARDKWG 1734
Query: 405 K 405
K
Sbjct: 1735 K 1735
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/160 (22%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 521 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 580
A+VL + Y + G I + + + KD+F+F++++++ + + ++ + N +
Sbjct: 547 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAF---MIGMFNLYS 602
Query: 581 NMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSST-KYPVVFI--- 636
+ + TV E+F T +F L+ E++S KY FI
Sbjct: 603 YYRGAKYNPAFTTV--------EESFKTLFWSIFGLS------EVISVVLKYDHKFIENI 648
Query: 637 --ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWK 674
+L Y + V+LLNMLIA++ + ++ +++ WK
Sbjct: 649 GYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWK 688
>gi|169216484 PREDICTED: similar to transient receptor potential
channel subfamily C member 6 [Homo sapiens]
Length = 304
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/123 (21%), Positives = 59/123 (47%), Gaps = 11/123 (8%)
Query: 552 KDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLL 611
KD+FRF+L++++ + + + +L + ++K N T + ++TF+L
Sbjct: 145 KDIFRFMLIFIMVFVAFMIGMFNLYSYYIDVK------QNEAFTTVEESFKTLFWATFVL 198
Query: 612 DLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKH 671
K + + + + Y +L Y + ++LLNMLIA++ ++ ++ ++
Sbjct: 199 SAVKSVVINYSHKFIENIGY-----VLYGVYDVTMVIVLLNMLIAMINSSLQEIEDDADV 253
Query: 672 IWK 674
WK
Sbjct: 254 EWK 256
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 38.9 bits (89), Expect = 0.019
Identities = 39/160 (24%), Positives = 69/160 (43%), Gaps = 24/160 (15%)
Query: 521 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 580
A+VL + Y + G I + + + KD+F+F++++++ + + L +
Sbjct: 618 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYL 676
Query: 581 NMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSST-KYPVVFI--- 636
KV N T E+F T +F L+ E+ S KY FI
Sbjct: 677 GAKV------NAAFTTV-----EESFKTLFWSIFGLS------EVTSVVLKYDHKFIENI 719
Query: 637 --ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWK 674
+L Y + V+LLNMLIA++ + ++ +S WK
Sbjct: 720 GYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 759
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 38.9 bits (89), Expect = 0.019
Identities = 39/160 (24%), Positives = 69/160 (43%), Gaps = 24/160 (15%)
Query: 521 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 580
A+VL + Y + G I + + + KD+F+F++++++ + + L +
Sbjct: 545 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYL 603
Query: 581 NMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSST-KYPVVFI--- 636
KV N T E+F T +F L+ E+ S KY FI
Sbjct: 604 GAKV------NAAFTTV-----EESFKTLFWSIFGLS------EVTSVVLKYDHKFIENI 646
Query: 637 --ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWK 674
+L Y + V+LLNMLIA++ + ++ +S WK
Sbjct: 647 GYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWK 686
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 38.5 bits (88), Expect = 0.025
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 14/71 (19%)
Query: 237 RGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 296
+G TALHIA V++LV +GA+++AQ++ F PL +AA N
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 120
Query: 297 QPHIVNYLTEN 307
+V YL EN
Sbjct: 121 HIDVVKYLLEN 131
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 38.5 bits (88), Expect = 0.025
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 14/71 (19%)
Query: 237 RGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 296
+G TALHIA V++LV +GA+++AQ++ F PL +AA N
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141
Query: 297 QPHIVNYLTEN 307
+V YL EN
Sbjct: 142 HIDVVKYLLEN 152
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 38.5 bits (88), Expect = 0.025
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 14/71 (19%)
Query: 237 RGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 296
+G TALHIA V++LV +GA+++AQ++ F PL +AA N
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--------------TPLYMAAQEN 141
Query: 297 QPHIVNYLTEN 307
+V YL EN
Sbjct: 142 HIDVVKYLLEN 152
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 38.1 bits (87), Expect = 0.033
Identities = 30/154 (19%), Positives = 69/154 (44%), Gaps = 12/154 (7%)
Query: 521 ALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCA 580
A+VL + Y + G I + + + KD+F+F++++++ + + + +L +
Sbjct: 602 AVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSYYI 660
Query: 581 NMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLV 640
K +++ TV E+F T +F L+ + + + +L
Sbjct: 661 GAK---QNEAFTTV--------EESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYG 709
Query: 641 TYIILTFVLLLNMLIALMGETVGQVSKESKHIWK 674
Y + ++LLNMLIA++ + ++ ++ WK
Sbjct: 710 VYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 743
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 37.7 bits (86), Expect = 0.043
Identities = 30/90 (33%), Positives = 38/90 (42%), Gaps = 17/90 (18%)
Query: 237 RGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 296
RG T LH+A ++LLV++GA V+A Y G PL LA
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATD--------------YHGATPLHLACQKG 507
Query: 297 QPHIVNYLTENPHKKADMRRQDSRGNTVLH 326
+ L H KA QD+ GNT LH
Sbjct: 508 YQSVTLLLL---HYKASAEVQDNNGNTPLH 534
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 37.4 bits (85), Expect = 0.056
Identities = 36/146 (24%), Positives = 66/146 (45%), Gaps = 20/146 (13%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSL--------LNPCANMKVCNEDQTN 591
G I + ++L D+ +FL +Y L ++ +A+ L L ++ N K ++ N
Sbjct: 504 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQN 562
Query: 592 CTVPTYPSCRDSETFSTF-LLDLFKLTIGMGD--LEMLSSTKYPVVFIILLVTYIILTFV 648
T S +S F LL+L+ + E + +T + TY +++ V
Sbjct: 563 NAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFG--------TYNVISLV 614
Query: 649 LLLNMLIALMGETVGQVSKESKHIWK 674
+LLNMLIA+M + ++ + WK
Sbjct: 615 VLLNMLIAMMNNSYQLIADHADIEWK 640
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 37.4 bits (85), Expect = 0.056
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPS 599
G I + ++L D+ +FL +Y L ++ +A+ L L E+ T
Sbjct: 330 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY-------FYYEETKGLTCKGIRC 381
Query: 600 CRDSETFSTF---LLDLFKLTIGMGDLEMLSSTKY----PVVFIILLVTYIILTFVLLLN 652
+ + FST L LF G+ +L + + V + TY +++ V+LLN
Sbjct: 382 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 441
Query: 653 MLIALMGETVGQVSKESKHIWK 674
MLIA+M + ++ + WK
Sbjct: 442 MLIAMMNNSYQLIADHADIEWK 463
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 37.4 bits (85), Expect = 0.056
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPS 599
G I + ++L D+ +FL +Y L ++ +A+ L L E+ T
Sbjct: 503 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY-------FYYEETKGLTCKGIRC 554
Query: 600 CRDSETFSTF---LLDLFKLTIGMGDLEMLSSTKY----PVVFIILLVTYIILTFVLLLN 652
+ + FST L LF G+ +L + + V + TY +++ V+LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614
Query: 653 MLIALMGETVGQVSKESKHIWK 674
MLIA+M + ++ + WK
Sbjct: 615 MLIAMMNNSYQLIADHADIEWK 636
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 37.4 bits (85), Expect = 0.056
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPS 599
G I + ++L D+ +FL +Y L ++ +A+ L L E+ T
Sbjct: 503 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY-------FYYEETKGLTCKGIRC 554
Query: 600 CRDSETFSTF---LLDLFKLTIGMGDLEMLSSTKY----PVVFIILLVTYIILTFVLLLN 652
+ + FST L LF G+ +L + + V + TY +++ V+LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614
Query: 653 MLIALMGETVGQVSKESKHIWK 674
MLIA+M + ++ + WK
Sbjct: 615 MLIAMMNNSYQLIADHADIEWK 636
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 37.4 bits (85), Expect = 0.056
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPS 599
G I + ++L D+ +FL +Y L ++ +A+ L L E+ T
Sbjct: 503 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY-------FYYEETKGLTCKGIRC 554
Query: 600 CRDSETFSTF---LLDLFKLTIGMGDLEMLSSTKY----PVVFIILLVTYIILTFVLLLN 652
+ + FST L LF G+ +L + + V + TY +++ V+LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614
Query: 653 MLIALMGETVGQVSKESKHIWK 674
MLIA+M + ++ + WK
Sbjct: 615 MLIAMMNNSYQLIADHADIEWK 636
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 37.4 bits (85), Expect = 0.056
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 540 GTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPS 599
G I + ++L D+ +FL +Y L ++ +A+ L L E+ T
Sbjct: 503 GPLQISLGRMLL-DILKFLFIYCLVLLAFANGLNQLY-------FYYEETKGLTCKGIRC 554
Query: 600 CRDSETFSTF---LLDLFKLTIGMGDLEMLSSTKY----PVVFIILLVTYIILTFVLLLN 652
+ + FST L LF G+ +L + + V + TY +++ V+LLN
Sbjct: 555 EKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLN 614
Query: 653 MLIALMGETVGQVSKESKHIWK 674
MLIA+M + ++ + WK
Sbjct: 615 MLIAMMNNSYQLIADHADIEWK 636
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,162,382
Number of Sequences: 37866
Number of extensions: 1672353
Number of successful extensions: 7132
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 6649
Number of HSP's gapped (non-prelim): 553
length of query: 811
length of database: 18,247,518
effective HSP length: 111
effective length of query: 700
effective length of database: 14,044,392
effective search space: 9831074400
effective search space used: 9831074400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.