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Search of human proteins with 22507409
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 1053 0.0
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 638 0.0
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 92 9e-19
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 87 3e-17
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 87 3e-17
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 87 3e-17
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 75 2e-13
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 70 4e-12
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 69 1e-11
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 65 1e-10
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 60 4e-09
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 60 4e-09
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 54 3e-07
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 54 4e-07
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 54 4e-07
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] 54 4e-07
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 53 8e-07
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 52 1e-06
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 52 1e-06
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 49 1e-05
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 49 1e-05
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 49 1e-05
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 49 1e-05
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 48 2e-05
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 46 7e-05
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 46 7e-05
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 46 7e-05
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 46 9e-05
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 45 2e-04
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 43 6e-04
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 1053 bits (2724), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 60
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
Sbjct: 1 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 60
Query: 61 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL 120
FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
Sbjct: 61 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL 120
Query: 121 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS 180
QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
Sbjct: 121 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS 180
Query: 181 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP 240
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
Sbjct: 181 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP 240
Query: 241 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE 300
ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
Sbjct: 241 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE 300
Query: 301 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE 360
IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
Sbjct: 301 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE 360
Query: 361 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR 420
ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
Sbjct: 361 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR 420
Query: 421 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF 480
WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
Sbjct: 421 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF 480
Query: 481 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 517
LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
Sbjct: 481 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 517
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 638 bits (1646), Expect = 0.0
Identities = 320/520 (61%), Positives = 396/520 (76%), Gaps = 18/520 (3%)
Query: 1 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 60
MA++ + KQFWKRS +KLPGSIQ VYGAQHPP DP L ++ +K+ T P+K K+ S+
Sbjct: 1 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS 58
Query: 61 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG 119
F EF NTSDAWD G+D++E + + ++LNS+V + TA +VL NHS+
Sbjct: 59 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------ 106
Query: 120 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG 178
L+ KP S + +++KS S++ S + PL + QSLP + L
Sbjct: 107 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR 166
Query: 179 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY 238
SD + + ++ RE +RL+KF+QLL+ NTDL+ELR+ SW G+P+ VRP+TW+LLSGY
Sbjct: 167 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY 226
Query: 239 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK 297
LPAN +RR TLQRK++EYF FIE YYDSRN+E HQDTYRQIHIDIPR +P L QP
Sbjct: 227 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL 286
Query: 298 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC 357
V EIFERILFIWAIRHPASGYVQGINDLVTPFFVVF+ EY+E E+V+ DV+ + ++L
Sbjct: 287 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR 345
Query: 358 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF 417
+IEAD++WCMSKLLDGIQDNYTFAQPGIQ KVK LEELVSRIDEQVH H ++EV YLQF
Sbjct: 346 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF 405
Query: 418 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL 477
AFRWMNNLLMRE+PLRCTIRLWDTYQSEP+GFSHFHLYVCAAFL++WRKEIL+E+DFQ L
Sbjct: 406 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL 465
Query: 478 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 517
L+ LQNLPT HW +E+I LLLAEAYRLK+ FADAPNHY++
Sbjct: 466 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR 505
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 92.4 bits (228), Expect = 9e-19
Identities = 65/210 (30%), Positives = 109/210 (51%), Gaps = 25/210 (11%)
Query: 300 EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNI 359
E+ ERILFI+A +P YVQG+N++V P + F + +E +
Sbjct: 209 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATD--------------PNSEWKEHA 254
Query: 360 EADTYWCMSKLLDGIQDNYTFA----QPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYL 415
EADT++C + L+ I+DN+ + Q GI K++ + + D +++ L + ++
Sbjct: 255 EADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQ 314
Query: 416 QFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQ 475
FAFRW+ LL +E L IR+WD+ ++ + F F L VC A L+ R+++L E DF
Sbjct: 315 FFAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFD-FLLLVCCAMLMLIREQLL-EGDFT 372
Query: 476 ELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
+ LQ+ P D+ +L +A L+
Sbjct: 373 VNMRLLQDYPIT-----DVCQILQKAKELQ 397
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/74 (35%), Positives = 42/74 (56%), Gaps = 2/74 (2%)
Query: 190 LSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIP--KPVRPMTWKLLSGYLPANVDRRP 247
+S SR+ F+ +L P+ LE+LR LS+SGIP +R + WK+L YLP
Sbjct: 1 MSSLHKSRIADFQDVLKEPSIALEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWT 60
Query: 248 ATLQRKQKEYFAFI 261
+ L ++++ Y F+
Sbjct: 61 SILAKQRELYAQFL 74
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 87.4 bits (215), Expect = 3e-17
Identities = 77/296 (26%), Positives = 125/296 (42%), Gaps = 40/296 (13%)
Query: 222 GIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAF------IEHYYDSRNDEVH 273
G+ +R WK L GY P + + T +KQK EYF I + RN +
Sbjct: 337 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRL- 395
Query: 274 QDTYRQIHIDIPRMSPEALILQPKVTE---IFERILFIWAIRHPASGYVQGINDLVTPFF 330
+D I D+ R + + + IL + + GYVQG++DL++P
Sbjct: 396 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 455
Query: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVK 390
V E D +WC + +D + N+ G++ ++
Sbjct: 456 YVM------------------------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLI 491
Query: 391 MLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS 450
L L+ +D +L+ + YL F FRW+ RE +RLW+ +E +
Sbjct: 492 QLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CT 550
Query: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
+FHL +C A L +++I+E+ F E+L + L + D EDI L AEA L+
Sbjct: 551 NFHLLLCCAILESEKQQIMEKHYGFNEILKHINEL-SMKIDVEDI-LCKAEAISLQ 604
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 87.4 bits (215), Expect = 3e-17
Identities = 77/296 (26%), Positives = 125/296 (42%), Gaps = 40/296 (13%)
Query: 222 GIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAF------IEHYYDSRNDEVH 273
G+ +R WK L GY P + + T +KQK EYF I + RN +
Sbjct: 351 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRL- 409
Query: 274 QDTYRQIHIDIPRMSPEALILQPKVTE---IFERILFIWAIRHPASGYVQGINDLVTPFF 330
+D I D+ R + + + IL + + GYVQG++DL++P
Sbjct: 410 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 469
Query: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVK 390
V E D +WC + +D + N+ G++ ++
Sbjct: 470 YVM------------------------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLI 505
Query: 391 MLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS 450
L L+ +D +L+ + YL F FRW+ RE +RLW+ +E +
Sbjct: 506 QLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CT 564
Query: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
+FHL +C A L +++I+E+ F E+L + L + D EDI L AEA L+
Sbjct: 565 NFHLLLCCAILESEKQQIMEKHYGFNEILKHINEL-SMKIDVEDI-LCKAEAISLQ 618
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 87.4 bits (215), Expect = 3e-17
Identities = 77/296 (26%), Positives = 125/296 (42%), Gaps = 40/296 (13%)
Query: 222 GIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAF------IEHYYDSRNDEVH 273
G+ +R WK L GY P + + T +KQK EYF I + RN +
Sbjct: 368 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRL- 426
Query: 274 QDTYRQIHIDIPRMSPEALILQPKVTE---IFERILFIWAIRHPASGYVQGINDLVTPFF 330
+D I D+ R + + + IL + + GYVQG++DL++P
Sbjct: 427 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 486
Query: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVK 390
V E D +WC + +D + N+ G++ ++
Sbjct: 487 YVM------------------------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLI 522
Query: 391 MLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS 450
L L+ +D +L+ + YL F FRW+ RE +RLW+ +E +
Sbjct: 523 QLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTELP-CT 581
Query: 451 HFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
+FHL +C A L +++I+E+ F E+L + L + D EDI L AEA L+
Sbjct: 582 NFHLLLCCAILESEKQQIMEKHYGFNEILKHINEL-SMKIDVEDI-LCKAEAISLQ 635
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 52/314 (16%)
Query: 216 RRLSWSGIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVH 273
+ + + GI +R W L Y + + R A +K+KEY + I+ S E H
Sbjct: 419 KAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEY-SEIQQKRLSMTPEEH 477
Query: 274 QDTYRQIHI----DIPRMSPEALILQ----PKVTEIFERILFIWAIRHPASGYVQGINDL 325
+ +R + D+ R + P V E RIL +A+ +PA GY QG++DL
Sbjct: 478 RAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNV-ESMRRILLNYAVYNPAVGYSQGMSDL 536
Query: 326 VTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGI 385
V P I AE +D E+DT+WC L+ + +
Sbjct: 537 VAP---------ILAEVLD---------------ESDTFWCFVGLMQNTIFVSSPRDEDM 572
Query: 386 QMKVKMLEELVSRIDEQVHRHLDQHEVRYLQ--FAFRWMNNLLMREVPLRCTIRLWDT-- 441
+ ++ L EL+ + ++HL LQ F RW+ RE P +R+W+
Sbjct: 573 EKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACW 632
Query: 442 --YQSEPDGFSHFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLL 498
YQ++ +FHL++C A + + +++E++ ++LL NL H + E L+L
Sbjct: 633 AHYQTD-----YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNL-AMHMNGE---LVL 683
Query: 499 AEAYRLKFAFADAP 512
+A L + F P
Sbjct: 684 RKARSLLYQFRLLP 697
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 70.5 bits (171), Expect = 4e-12
Identities = 66/271 (24%), Positives = 107/271 (39%), Gaps = 43/271 (15%)
Query: 207 GPNTDLEEL----RRLSWSGIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAF 260
GP L+++ R+ G+ +R WK L GYL + A +++K EYF
Sbjct: 291 GPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRM 350
Query: 261 ------IEHYYDSRNDEVHQDTYRQ-IHIDIPRMSPEALILQPKVTE---IFERILFIWA 310
+ + RN +H YR I D+ R + + IL +
Sbjct: 351 KLQWKSVSPEQERRNSLLHG--YRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYC 408
Query: 311 IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKL 370
+ H GYVQG++DL++P V E D +WC
Sbjct: 409 MYHFDLGYVQGMSDLLSPILYVI------------------------QNEVDAFWCFCGF 444
Query: 371 LDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREV 430
++ +Q N+ +Q ++ ++ L L+ +D + LD + L F FRW+ RE
Sbjct: 445 MELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREF 504
Query: 431 PLRCTIRLWDTYQSEPDGFSHFHLYVCAAFL 461
P +RLW+ + G + HL V A L
Sbjct: 505 PFPDVLRLWEVLWTGLPG-PNLHLLVACAIL 534
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/323 (23%), Positives = 122/323 (37%), Gaps = 50/323 (15%)
Query: 167 SLPHS-ATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPK 225
+LPHS + L + + +E + +R+ F +LL ++ + + IP
Sbjct: 347 NLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPP 406
Query: 226 PVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIP 285
+R +TW L G A I YD+ + + T RQI +DIP
Sbjct: 407 LMRGLTWAALLGVEGA-------------------IHAKYDAIDKDTPIPTDRQIEVDIP 447
Query: 286 RMSP-EALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVD 344
R + L+ P+ F R+L W + HP Y QG++ L PF +
Sbjct: 448 RCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNF---------- 497
Query: 345 TVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPG--IQMKVKMLEELVSRIDEQ 402
N EA Y CMS + N+ IQ + + ++++ D +
Sbjct: 498 -------------NNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPE 544
Query: 403 VHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLV 462
+ HL++ +A W + PL LWDT G S F + A L
Sbjct: 545 LSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLL---GNSSFPFCIGVAILQ 601
Query: 463 RWRKEILEEKDFQELLLFLQNLP 485
+ R +L F E +L +LP
Sbjct: 602 QLRDRLL-ANGFNECILLFSDLP 623
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 65.5 bits (158), Expect = 1e-10
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 49/303 (16%)
Query: 213 EELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEV 272
E+LR L +GIP +RP W LSG LQ+K+ ++ E +S NDE
Sbjct: 105 EKLRSLVLAGIPHGMRPQLWMRLSG-----------ALQKKRNSELSYREIVKNSSNDET 153
Query: 273 HQDTYRQIHIDIPRMSPEALILQPKVT---EIFERILFIWAIRHPASGYVQGINDLVTPF 329
+QI D+ R P + R+L A +P GY QG
Sbjct: 154 I--AAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTG------ 205
Query: 330 FVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQP--GIQM 387
+V C + EE D +W MS +++ + F+ G+Q
Sbjct: 206 -MVAACLLLFLEE------------------EDAFWMMSAIIEDLLPASYFSTTLLGVQT 246
Query: 388 KVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPD 447
++L L+ + ++ + L +H++ W V ++ +R+WD + E
Sbjct: 247 DQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEG- 305
Query: 448 GFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFA 507
S + L +E+++ ++ + L ++P+ ED LLL A RL +
Sbjct: 306 --SRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS---QMEDAELLLGVAMRLAGS 360
Query: 508 FAD 510
D
Sbjct: 361 LTD 363
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 60.5 bits (145), Expect = 4e-09
Identities = 61/276 (22%), Positives = 113/276 (40%), Gaps = 47/276 (17%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAFIEHYYDSRNDE 271
EL+ L +GIP R WK VDR + + + ++ + +N
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWC-------VDRHTRKFKDNTEPGHFQTLLQKALEKQNP- 705
Query: 272 VHQDTYRQIHIDIPRMSPEALILQPKVTEIFER---ILFIWAIRHPASGYVQGINDLVTP 328
+QI +D+ R P +E ++ +L ++ R+P GY QG+N LV
Sbjct: 706 ----ASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAV 761
Query: 329 FFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGI--QDNYTFAQPGIQ 386
+ Y+E E D +WC+ +++ +D YT G Q
Sbjct: 762 ALL-----YLEQE--------------------DAFWCLVTIVEVFMPRDYYTKTLLGSQ 796
Query: 387 MKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEP 446
+ ++ +L+S ++H H +Q++V Y F W + + V ++WD++ E
Sbjct: 797 VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYE- 855
Query: 447 DGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQ 482
G + A F + +EIL+ +D + +L+
Sbjct: 856 -GPKVIFRFALALFKYK-EEEILKLQDSMSIFKYLR 889
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 60.5 bits (145), Expect = 4e-09
Identities = 61/276 (22%), Positives = 113/276 (40%), Gaps = 47/276 (17%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK--EYFAFIEHYYDSRNDE 271
EL+ L +GIP R WK VDR + + + ++ + +N
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWC-------VDRHTRKFKDNTEPGHFQTLLQKALEKQNP- 705
Query: 272 VHQDTYRQIHIDIPRMSPEALILQPKVTEIFER---ILFIWAIRHPASGYVQGINDLVTP 328
+QI +D+ R P +E ++ +L ++ R+P GY QG+N LV
Sbjct: 706 ----ASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAV 761
Query: 329 FFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGI--QDNYTFAQPGIQ 386
+ Y+E E D +WC+ +++ +D YT G Q
Sbjct: 762 ALL-----YLEQE--------------------DAFWCLVTIVEVFMPRDYYTKTLLGSQ 796
Query: 387 MKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEP 446
+ ++ +L+S ++H H +Q++V Y F W + + V ++WD++ E
Sbjct: 797 VDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYE- 855
Query: 447 DGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQ 482
G + A F + +EIL+ +D + +L+
Sbjct: 856 -GPKVIFRFALALFKYK-EEEILKLQDSMSIFKYLR 889
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 54.3 bits (129), Expect = 3e-07
Identities = 53/237 (22%), Positives = 89/237 (37%), Gaps = 42/237 (17%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVH 273
EL++L +G+P+ RP W+ L +L P Q SR
Sbjct: 617 ELKQLLRAGVPREHRPRVWRWLV-HLRVQHLHTPGCYQELL------------SRGQARE 663
Query: 274 QDTYRQIHIDIPRMSPEALILQPKVTEI---FERILFIWAIRHPASGYVQGINDLVTPFF 330
RQI +D+ R P + R+L ++ ++P GY QG+N L
Sbjct: 664 HPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIAL 723
Query: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQ--DNYTFAQPGIQMK 388
+V +E EE +WC+ +++ I D Y Q+
Sbjct: 724 LV-----LEEEE-------------------SAFWCLVAIVETIMPADYYCNTLTASQVD 759
Query: 389 VKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSE 445
++L++L+S ++ HL QH V F W + + +R+WD + E
Sbjct: 760 QRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYE 816
>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
Length = 817
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 46/243 (18%)
Query: 280 IHIDIPRMSPEALILQPK-VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICE-- 336
I D+ R PE Q + V +I +LF +A + Y QG+++L+ P V C+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
Query: 337 -YIEAEEVDTVDVSGVPAEVLCNI------EADTYWCMSKLL------------DGIQDN 377
++ A E S P+E + + E D Y S+L+ DG +
Sbjct: 223 AFLHASE------SAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK 276
Query: 378 YT------FAQP-------GIQMKVKMLEE-LVSRIDEQVHRHLDQHEVRYLQFAFRWMN 423
T FA+P I KV +++ L+ + D +++ HL++ E+ + RW+
Sbjct: 277 ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVR 336
Query: 424 NLLMREVPLRCTIRLWDTYQSEPDGFSHFHL-YVCAAFLVRWRKEILEEKDFQELLLFLQ 482
L RE PL+ + +WD + DG S + Y+ A L+ + ++ L ++Q L L
Sbjct: 337 LLFGREFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLL-YIRDALISSNYQTCLGLLM 393
Query: 483 NLP 485
+ P
Sbjct: 394 HYP 396
>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 46/243 (18%)
Query: 280 IHIDIPRMSPEALILQPK-VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICE-- 336
I D+ R PE Q + V +I +LF +A + Y QG+++L+ P V C+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
Query: 337 -YIEAEEVDTVDVSGVPAEVLCNI------EADTYWCMSKLL------------DGIQDN 377
++ A E S P+E + + E D Y S+L+ DG +
Sbjct: 223 AFLHASE------SAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK 276
Query: 378 YT------FAQP-------GIQMKVKMLEE-LVSRIDEQVHRHLDQHEVRYLQFAFRWMN 423
T FA+P I KV +++ L+ + D +++ HL++ E+ + RW+
Sbjct: 277 ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVR 336
Query: 424 NLLMREVPLRCTIRLWDTYQSEPDGFSHFHL-YVCAAFLVRWRKEILEEKDFQELLLFLQ 482
L RE PL+ + +WD + DG S + Y+ A L+ + ++ L ++Q L L
Sbjct: 337 LLFGREFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLL-YIRDALISSNYQTCLGLLM 393
Query: 483 NLP 485
+ P
Sbjct: 394 HYP 396
>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 46/243 (18%)
Query: 280 IHIDIPRMSPEALILQPK-VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICE-- 336
I D+ R PE Q + V +I +LF +A + Y QG+++L+ P V C+
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
Query: 337 -YIEAEEVDTVDVSGVPAEVLCNI------EADTYWCMSKLL------------DGIQDN 377
++ A E S P+E + + E D Y S+L+ DG +
Sbjct: 223 AFLHASE------SAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK 276
Query: 378 YT------FAQP-------GIQMKVKMLEE-LVSRIDEQVHRHLDQHEVRYLQFAFRWMN 423
T FA+P I KV +++ L+ + D +++ HL++ E+ + RW+
Sbjct: 277 ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVR 336
Query: 424 NLLMREVPLRCTIRLWDTYQSEPDGFSHFHL-YVCAAFLVRWRKEILEEKDFQELLLFLQ 482
L RE PL+ + +WD + DG S + Y+ A L+ + ++ L ++Q L L
Sbjct: 337 LLFGREFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLL-YIRDALISSNYQTCLGLLM 393
Query: 483 NLP 485
+ P
Sbjct: 394 HYP 396
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 52.8 bits (125), Expect = 8e-07
Identities = 62/282 (21%), Positives = 108/282 (38%), Gaps = 42/282 (14%)
Query: 215 LRRLSWSGIPKPVRPMTWKLLSG-YLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEV- 272
+R L W G+P VR W L G L + L R ++ + +F E ++ + V
Sbjct: 477 VRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVS 536
Query: 273 ---HQDTYRQIHIDIPRMSPEALILQP--KVTEIFERILFIWAIRHPASGYVQGINDLVT 327
+ + I +DI R P I Q ++ IL + P GYVQG
Sbjct: 537 VADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQG------ 590
Query: 328 PFFVVFICEYIEAEEVDTVDVSGVPAEVLCNI-EADTYWCMSKLLDGIQDNYTFAQPGIQ 386
+S + A ++ N+ EAD + + LL+ F +
Sbjct: 591 --------------------MSFIAAVLILNLEEADAFIAFANLLNK-PCQLAFFRVDHS 629
Query: 387 MKVKMLEELVSRIDEQVHR---HLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQ 443
M +K +E + + H + + + W+ L + +PL R+WD +
Sbjct: 630 MMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFC 689
Query: 444 SEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLP 485
+ + F L+ ++R ++IL + DF + FL LP
Sbjct: 690 RDGEEF----LFRTGLGILRLYEDILLQMDFIHIAQFLTKLP 727
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 52.4 bits (124), Expect = 1e-06
Identities = 63/336 (18%), Positives = 132/336 (39%), Gaps = 55/336 (16%)
Query: 194 EASRLDKFKQLLAG--PNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQ 251
E R K+ ++L G + E+ R + GIP +R W LL ++
Sbjct: 70 EIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEI---------PKMK 120
Query: 252 RKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKV---TEIFERILFI 308
+ ++ ++ ++H + ++ RQI +D+ R + ++ + + + +L
Sbjct: 121 EETRDLYSKLKHRARGCSPDI-----RQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAA 175
Query: 309 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS 368
++I + GY QG++ +T ++++ E D +W +
Sbjct: 176 YSIYNTEVGYCQGMSQ-ITALLLMYMNE------------------------EDAFWALV 210
Query: 369 KLLDG----IQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNN 424
KL G + + P + + E+++++ ++ +HLD E+ + +W
Sbjct: 211 KLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQ 270
Query: 425 LLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNL 484
+ P +R+WD Y E + L + +++ K+ L + +EL+ F Q
Sbjct: 271 CFLDRTPFTLNLRIWDIYIFEGERV----LTAMSYTILKLHKKHLMKLSMEELVEFFQET 326
Query: 485 PTAHW---DDEDISLLLAEAYRLKFAFADAPNHYKK 517
+ DD I L LK A D P K+
Sbjct: 327 LAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKE 362
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 52.4 bits (124), Expect = 1e-06
Identities = 63/336 (18%), Positives = 132/336 (39%), Gaps = 55/336 (16%)
Query: 194 EASRLDKFKQLLAG--PNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQ 251
E R K+ ++L G + E+ R + GIP +R W LL ++
Sbjct: 87 EIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEI---------PKMK 137
Query: 252 RKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKV---TEIFERILFI 308
+ ++ ++ ++H + ++ RQI +D+ R + ++ + + + +L
Sbjct: 138 EETRDLYSKLKHRARGCSPDI-----RQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAA 192
Query: 309 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS 368
++I + GY QG++ +T ++++ E D +W +
Sbjct: 193 YSIYNTEVGYCQGMSQ-ITALLLMYMNE------------------------EDAFWALV 227
Query: 369 KLLDG----IQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNN 424
KL G + + P + + E+++++ ++ +HLD E+ + +W
Sbjct: 228 KLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQ 287
Query: 425 LLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNL 484
+ P +R+WD Y E + L + +++ K+ L + +EL+ F Q
Sbjct: 288 CFLDRTPFTLNLRIWDIYIFEGERV----LTAMSYTILKLHKKHLMKLSMEELVEFFQET 343
Query: 485 PTAHW---DDEDISLLLAEAYRLKFAFADAPNHYKK 517
+ DD I L LK A D P K+
Sbjct: 344 LAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKE 379
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)
Query: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338
+I D+ R P E I+ + +H GYVQG+ DL+ P V+
Sbjct: 822 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 876
Query: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398
+ EA + C ++L+ + N+ + + L+
Sbjct: 877 -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 916
Query: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456
+D ++ + Q+ + + F +RW RE+ +W+T + ++ +H+ L++
Sbjct: 917 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 976
Query: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
A + +R ILE DF +++ F + H + + L Y+++
Sbjct: 977 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1026
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)
Query: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338
+I D+ R P E I+ + +H GYVQG+ DL+ P V+
Sbjct: 883 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 937
Query: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398
+ EA + C ++L+ + N+ + + L+
Sbjct: 938 -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 977
Query: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456
+D ++ + Q+ + + F +RW RE+ +W+T + ++ +H+ L++
Sbjct: 978 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 1037
Query: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
A + +R ILE DF +++ F + H + + L Y+++
Sbjct: 1038 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1087
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)
Query: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338
+I D+ R P E I+ + +H GYVQG+ DL+ P V+
Sbjct: 877 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 931
Query: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398
+ EA + C ++L+ + N+ + + L+
Sbjct: 932 -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 971
Query: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456
+D ++ + Q+ + + F +RW RE+ +W+T + ++ +H+ L++
Sbjct: 972 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 1031
Query: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
A + +R ILE DF +++ F + H + + L Y+++
Sbjct: 1032 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1081
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)
Query: 279 QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338
+I D+ R P E I+ + +H GYVQG+ DL+ P V+
Sbjct: 938 RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 992
Query: 339 EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398
+ EA + C ++L+ + N+ + + L+
Sbjct: 993 -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 1032
Query: 399 IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456
+D ++ + Q+ + + F +RW RE+ +W+T + ++ +H+ L++
Sbjct: 1033 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 1092
Query: 457 CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505
A + +R ILE DF +++ F + H + + L Y+++
Sbjct: 1093 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1142
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 47.8 bits (112), Expect = 2e-05
Identities = 59/281 (20%), Positives = 109/281 (38%), Gaps = 49/281 (17%)
Query: 197 RLDKFKQLLAGPNTDLEE-LRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQK 255
R K+ +LL G ++R G+P R W +LSG A +D+ P
Sbjct: 42 RAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSG-AQAQMDQNPG------- 93
Query: 256 EYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFER----ILFIWAI 311
+Y+ E + I D+ R P+ + + +R +L +
Sbjct: 94 -------YYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGH 146
Query: 312 RHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLL 371
+ GY QG+N FI Y+ ++ N E +++W + L+
Sbjct: 147 HNQGVGYCQGMN---------FIAGYLI---------------LITNNEEESFWLLDALV 182
Query: 372 DGI-QDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREV 430
I D Y+ A G++ ++L ELV V +++ V + RW L + +
Sbjct: 183 GRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDIL 242
Query: 431 PLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEE 471
P+ +R+WD +E ++ A L++ +E++ E
Sbjct: 243 PVETVLRIWDCLFNEGSKI----IFRVALTLIKQHQELILE 279
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 46.2 bits (108), Expect = 7e-05
Identities = 60/284 (21%), Positives = 110/284 (38%), Gaps = 42/284 (14%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGY-LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEV 272
++R L W GIP VR W L G L + L R ++ + + + N++
Sbjct: 113 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 172
Query: 273 ------HQDTYRQIHIDIPRMSPEALILQP--KVTEIFERILFIWAIRHPASGYVQGIND 324
+ + I +DI R P I Q ++ IL + P GYVQG+
Sbjct: 173 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-- 230
Query: 325 LVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE-ADTYWCMSKLLDG-IQDNYTFAQ 382
S + A ++ N++ AD + S LL+ Q +
Sbjct: 231 ------------------------SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVD 266
Query: 383 PGIQMKVKMLEELVSRID-EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDT 441
G+ + E+ + ++ H ++ + + W+ L + +PL R+WD
Sbjct: 267 HGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDV 326
Query: 442 YQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLP 485
+ + + F L+ A +++ ++IL + DF + FL LP
Sbjct: 327 FCRDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 366
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 46.2 bits (108), Expect = 7e-05
Identities = 60/284 (21%), Positives = 110/284 (38%), Gaps = 42/284 (14%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGY-LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEV 272
++R L W GIP VR W L G L + L R ++ + + + N++
Sbjct: 393 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 452
Query: 273 ------HQDTYRQIHIDIPRMSPEALILQP--KVTEIFERILFIWAIRHPASGYVQGIND 324
+ + I +DI R P I Q ++ IL + P GYVQG+
Sbjct: 453 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-- 510
Query: 325 LVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE-ADTYWCMSKLLDG-IQDNYTFAQ 382
S + A ++ N++ AD + S LL+ Q +
Sbjct: 511 ------------------------SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVD 546
Query: 383 PGIQMKVKMLEELVSRID-EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDT 441
G+ + E+ + ++ H ++ + + W+ L + +PL R+WD
Sbjct: 547 HGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDV 606
Query: 442 YQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLP 485
+ + + F L+ A +++ ++IL + DF + FL LP
Sbjct: 607 FCRDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 646
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 46.2 bits (108), Expect = 7e-05
Identities = 60/284 (21%), Positives = 110/284 (38%), Gaps = 42/284 (14%)
Query: 214 ELRRLSWSGIPKPVRPMTWKLLSGY-LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEV 272
++R L W GIP VR W L G L + L R ++ + + + N++
Sbjct: 393 KVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENEDA 452
Query: 273 ------HQDTYRQIHIDIPRMSPEALILQP--KVTEIFERILFIWAIRHPASGYVQGIND 324
+ + I +DI R P I Q ++ IL + P GYVQG+
Sbjct: 453 GFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-- 510
Query: 325 LVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE-ADTYWCMSKLLDG-IQDNYTFAQ 382
S + A ++ N++ AD + S LL+ Q +
Sbjct: 511 ------------------------SFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVD 546
Query: 383 PGIQMKVKMLEELVSRID-EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDT 441
G+ + E+ + ++ H ++ + + W+ L + +PL R+WD
Sbjct: 547 HGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDV 606
Query: 442 YQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLP 485
+ + + F L+ A +++ ++IL + DF + FL LP
Sbjct: 607 FCRDGEEF----LFRTALGILKLFEDILTKMDFIHMAQFLTRLP 646
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 45.8 bits (107), Expect = 9e-05
Identities = 75/356 (21%), Positives = 128/356 (35%), Gaps = 88/356 (24%)
Query: 117 GPGLQQKPRPEA-------EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLP 169
GPG+ PR +A + S SG L +S+++ +S ++S + L+++
Sbjct: 253 GPGISG-PRGQAPDTLSYLDSVSLMSGTL---ESLADDVSSMGSDSEINGLALRKTDKYG 308
Query: 170 HSATVTLGGTSDPSTLSSS----ALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPK 225
LGG+ +L SS +RE LD F + ++++ GIP
Sbjct: 309 F-----LGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPS 363
Query: 226 PVRPMTWKLLSG---YLPAN------VDRRPA------TLQRKQKEYFAFIEHYYDSRND 270
+R W+ LS L N ++R P +++ F F E + +R
Sbjct: 364 SLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHE-MFAARGG 422
Query: 271 EVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFF 330
QD YR IL + I P GY Q
Sbjct: 423 HGQQDLYR--------------------------ILKAYTIYRPDEGYCQA--------- 447
Query: 331 VVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDG-IQDNYTFAQPGIQMKV 389
V V + +PAE +WC+ ++ D + Y+ IQ+
Sbjct: 448 ---------QAPVAAVLLMHMPAE-------QAFWCLVQICDKYLPGYYSAGLEAIQLDG 491
Query: 390 KMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSE 445
++ L+ R HRHL + + + + W + R +P +R+WD + E
Sbjct: 492 EIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCE 547
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/246 (21%), Positives = 92/246 (37%), Gaps = 40/246 (16%)
Query: 213 EELR-RLSWSGIPKPVRPMTWKLLSGYLPANVDRRPAT--LQRKQKEYFAFIEHYYDSRN 269
EELR R+ G+ +R + W+ L P + R ++RK +EY + N
Sbjct: 218 EELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRAN 277
Query: 270 DE--------VHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQG 321
E V +D R PE P + + + +L +A+ HP Y QG
Sbjct: 278 PEDLEFIRSTVLKDVLRTDRAHPYYAGPED---GPHLRALHD-LLTTYAVTHPQVSYCQG 333
Query: 322 INDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFA 381
++DL +P V + E + C ++ + N+
Sbjct: 334 MSDLASPILAVM------------------------DHEGHAFVCFCGIMKRLAANFHPD 369
Query: 382 QPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWD- 440
+ K L+ L+ D +++L + L F +RW+ L RE +R+ +
Sbjct: 370 GRAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 429
Query: 441 TYQSEP 446
T+ S P
Sbjct: 430 TWSSLP 435
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 43.1 bits (100), Expect = 6e-04
Identities = 53/258 (20%), Positives = 97/258 (37%), Gaps = 40/258 (15%)
Query: 190 LSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPAT 249
L +RE+ LD +++R GIP +R W+ LSG
Sbjct: 79 LRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSG--------GKVK 130
Query: 250 LQRKQKEYFAFIEHYYDSR-NDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFI 308
LQ+ ++ D + D + +D +RQ +S Q ++F R+L
Sbjct: 131 LQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQ----DLF-RVLKA 185
Query: 309 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS 368
+ + P GY Q P V + +PAE +WC+
Sbjct: 186 YTLYRPEEGYCQA----QAPIAAVLLMH--------------MPAE-------QAFWCLV 220
Query: 369 KLLDG-IQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLM 427
++ + + Y+ IQ+ ++L L+ ++ H+HL + ++ L + W
Sbjct: 221 QICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFS 280
Query: 428 REVPLRCTIRLWDTYQSE 445
R +P +R+WD + E
Sbjct: 281 RTLPWSSVLRVWDMFFCE 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,389,521
Number of Sequences: 37866
Number of extensions: 1019060
Number of successful extensions: 5340
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 5049
Number of HSP's gapped (non-prelim): 352
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.