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Search of human proteins with 22507405
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22507405 short chain dehydrogenase/reductase family 9C,
member 7 [Homo sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 629 e-180
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 340 1e-93
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 329 2e-90
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 299 2e-81
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 284 8e-77
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 284 8e-77
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 284 8e-77
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 284 8e-77
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 189 4e-48
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 189 4e-48
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 189 4e-48
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 161 8e-40
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 139 3e-33
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 85 9e-17
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 84 2e-16
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 70 2e-12
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 70 3e-12
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 69 7e-12
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 68 1e-11
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 68 1e-11
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 65 8e-11
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 64 2e-10
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 62 5e-10
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 62 5e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 62 9e-10
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 59 7e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 59 7e-09
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 58 9e-09
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 58 1e-08
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 57 2e-08
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 629 bits (1621), Expect = e-180
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE
Sbjct: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
Query: 61 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW
Sbjct: 61 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
Query: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180
LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE
Sbjct: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180
Query: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240
AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR
Sbjct: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240
Query: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300
IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF
Sbjct: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300
Query: 301 ILSRYLPRPADSV 313
ILSRYLPRPADSV
Sbjct: 301 ILSRYLPRPADSV 313
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 340 bits (871), Expect = 1e-93
Identities = 162/313 (51%), Positives = 229/313 (73%)
Query: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
+A L ++ W++ ++ +L +KYVFITGCDSGFG LLA+QL RG++VLAAC TE+
Sbjct: 5 LAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK 64
Query: 61 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
G+++L+ TS RL+T LDVTK+ES+ AAAQWV++ V ++GLW LVNNAG+ LP+ PNE
Sbjct: 65 GAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNEL 124
Query: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180
LTK DFV +++VNL+G+I+VTL +LP+V+RARGRVVN+SS GRV++ GGGYC+SK+GVE
Sbjct: 125 LTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVE 184
Query: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240
AFSDS+RREL YFGVKV +IEPG ++TA+ KE ++W+R E +++YGE +
Sbjct: 185 AFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVA 244
Query: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300
Y + + Q + V N MEHA+++ PR RY+ G DAKLLY+P++ +PT + D
Sbjct: 245 DYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDA 304
Query: 301 ILSRYLPRPADSV 313
I+ P PA ++
Sbjct: 305 IMYWVSPSPAKAL 317
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 329 bits (843), Expect = 2e-90
Identities = 159/313 (50%), Positives = 222/313 (70%)
Query: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
+AA L ++ W++ +V +L +KYVFITGCDSGFGNLLA+QL RG++VLAAC TE+
Sbjct: 5 LAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK 64
Query: 61 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
G+++L+ TS RL+T LDVTK ESI AA QWV++ VG++GLW LVNNAG+ P EW
Sbjct: 65 GAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEW 124
Query: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180
L +D + ++ VNL+G+I+VTL MLP+V+RARGR+VN+SS GRVA GGYCVSK+GVE
Sbjct: 125 LNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVE 184
Query: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240
AFSD +RRE+ +FGVK+ I+EPG +RT + RM++ W+ P+ +++YG+ YF
Sbjct: 185 AFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFD 244
Query: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300
+ +K + + V + MEHA+ S PR RY+ G DAK +IPL+ LPT + D+
Sbjct: 245 ALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADY 304
Query: 301 ILSRYLPRPADSV 313
IL+R P+PA +V
Sbjct: 305 ILTRSWPKPAQAV 317
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 299 bits (766), Expect = 2e-81
Identities = 149/291 (51%), Positives = 204/291 (70%), Gaps = 1/291 (0%)
Query: 24 SEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKS 83
S +VFITGCDSGFG LLA QL RG +VLA+C T G++ LQR S RL TTLLD+T
Sbjct: 27 SNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDP 86
Query: 84 ESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLH 143
+S++ AA+WV V E GL+ LVNNAGV GP WLT+DDF +V+NVN +G I VTL
Sbjct: 87 QSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLA 146
Query: 144 MLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRELYYFGVKVCIIEPG 203
+LP++++ARGRV+N++S GR+A GGGYCVSKFG+EAFSDS+RR++ +FG++V I+EPG
Sbjct: 147 LLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPG 206
Query: 204 NYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQ-VAEPRVRDVIN 262
+RT + E+LE ++ W RLP T+ YG + Y + IM + +P + V
Sbjct: 207 FFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSR 266
Query: 263 SMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSRYLPRPADSV 313
+EHA+ +R PR RY+PG DAKLL++P + LP + D +L+ LP+PA +V
Sbjct: 267 CLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAV 317
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 284 bits (726), Expect = 8e-77
Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)
Query: 11 YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69
+ W + L + ++++KY+FITGCDSGFGNL A+ +G V+AAC TE GS L+ +T
Sbjct: 14 FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 70 SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129
S RL+T LLDVT E++K AQWV+++VGE+GLW L+NNAGV P +WLT +D+ +
Sbjct: 74 SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
Query: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189
I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY SK+ VE F+DS+RR+
Sbjct: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
Query: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249
+ FGV V IEPG ++T + + + +WE+L + + YGE Y DKLK
Sbjct: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302
+ V+ M+HA+ S P+ Y G DAK+ +IPL+ +P + DF+L
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 284 bits (726), Expect = 8e-77
Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)
Query: 11 YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69
+ W + L + ++++KY+FITGCDSGFGNL A+ +G V+AAC TE GS L+ +T
Sbjct: 14 FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 70 SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129
S RL+T LLDVT E++K AQWV+++VGE+GLW L+NNAGV P +WLT +D+ +
Sbjct: 74 SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
Query: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189
I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY SK+ VE F+DS+RR+
Sbjct: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
Query: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249
+ FGV V IEPG ++T + + + +WE+L + + YGE Y DKLK
Sbjct: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302
+ V+ M+HA+ S P+ Y G DAK+ +IPL+ +P + DF+L
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 284 bits (726), Expect = 8e-77
Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)
Query: 11 YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69
+ W + L + ++++KY+FITGCDSGFGNL A+ +G V+AAC TE GS L+ +T
Sbjct: 14 FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 70 SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129
S RL+T LLDVT E++K AQWV+++VGE+GLW L+NNAGV P +WLT +D+ +
Sbjct: 74 SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
Query: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189
I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY SK+ VE F+DS+RR+
Sbjct: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
Query: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249
+ FGV V IEPG ++T + + + +WE+L + + YGE Y DKLK
Sbjct: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302
+ V+ M+HA+ S P+ Y G DAK+ +IPL+ +P + DF+L
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 284 bits (726), Expect = 8e-77
Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)
Query: 11 YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69
+ W + L + ++++KY+FITGCDSGFGNL A+ +G V+AAC TE GS L+ +T
Sbjct: 14 FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 70 SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129
S RL+T LLDVT E++K AQWV+++VGE+GLW L+NNAGV P +WLT +D+ +
Sbjct: 74 SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
Query: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189
I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY SK+ VE F+DS+RR+
Sbjct: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
Query: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249
+ FGV V IEPG ++T + + + +WE+L + + YGE Y DKLK
Sbjct: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302
+ V+ M+HA+ S P+ Y G DAK+ +IPL+ +P + DF+L
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 189 bits (479), Expect = 4e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 10/266 (3%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTLL 78
+ K V +TGCDSGFG LAK L +G V A C ++ G ++L S RL+T L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 79 DVTKSESIKAAAQWVRD--KVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
+V SE ++ + VR K E+G+W LVNNAG+ G E+ + + + +V VNL G
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWG 171
Query: 137 LIEVTLHMLPMVKRARGRVVNMSSSGGRVA-VIGGGYCVSKFGVEAFSDSIRRELYYFGV 195
+ +T LP+++RA+GRVVN+SS GR+A YC++KFGVEAFSD +R E+Y GV
Sbjct: 172 TVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGV 231
Query: 196 KVCIIEPGNY--RTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVA 253
KV ++EPGN+ T++ E++++ +K+WE LP+ R YG+ YF K++
Sbjct: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
Query: 254 EPRVRDVINSMEHAIVSRSPRIRYNP 279
VI+++ HA+ + +P RY+P
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 189 bits (479), Expect = 4e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 10/266 (3%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTLL 78
+ K V +TGCDSGFG LAK L +G V A C ++ G ++L S RL+T L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 79 DVTKSESIKAAAQWVRD--KVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
+V SE ++ + VR K E+G+W LVNNAG+ G E+ + + + +V VNL G
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWG 171
Query: 137 LIEVTLHMLPMVKRARGRVVNMSSSGGRVA-VIGGGYCVSKFGVEAFSDSIRRELYYFGV 195
+ +T LP+++RA+GRVVN+SS GR+A YC++KFGVEAFSD +R E+Y GV
Sbjct: 172 TVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGV 231
Query: 196 KVCIIEPGNY--RTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVA 253
KV ++EPGN+ T++ E++++ +K+WE LP+ R YG+ YF K++
Sbjct: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
Query: 254 EPRVRDVINSMEHAIVSRSPRIRYNP 279
VI+++ HA+ + +P RY+P
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 189 bits (479), Expect = 4e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 10/266 (3%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTLL 78
+ K V +TGCDSGFG LAK L +G V A C ++ G ++L S RL+T L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
Query: 79 DVTKSESIKAAAQWVRD--KVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
+V SE ++ + VR K E+G+W LVNNAG+ G E+ + + + +V VNL G
Sbjct: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWG 171
Query: 137 LIEVTLHMLPMVKRARGRVVNMSSSGGRVA-VIGGGYCVSKFGVEAFSDSIRRELYYFGV 195
+ +T LP+++RA+GRVVN+SS GR+A YC++KFGVEAFSD +R E+Y GV
Sbjct: 172 TVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGV 231
Query: 196 KVCIIEPGNY--RTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVA 253
KV ++EPGN+ T++ E++++ +K+WE LP+ R YG+ YF K++
Sbjct: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
Query: 254 EPRVRDVINSMEHAIVSRSPRIRYNP 279
VI+++ HA+ + +P RY+P
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 161 bits (407), Expect = 8e-40
Identities = 104/301 (34%), Positives = 160/301 (53%), Gaps = 7/301 (2%)
Query: 10 MYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEG--SQKLQR 67
MY + L+ + +K V +TG D G G+ L K L + G V A E G +++L+R
Sbjct: 68 MYTYLSGQELLP-VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRR 126
Query: 68 DTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGV-GLPSGPNEWLTKDDF 126
S RL +D+TK IK A V + ++GLWA++NNAGV G P+ E L D+
Sbjct: 127 TCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTD-GELLLMTDY 185
Query: 127 VKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDS 185
+ + VN G +EVT LP++++++GR+VN+SS GG + Y SK V FS
Sbjct: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
Query: 186 IRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRK-LWERLPQETRDSYGEDYFRIYTD 244
+R EL +G+KV I+PG + T I G + ++ K + + LP E ++ YG+DY +
Sbjct: 246 MRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRN 305
Query: 245 KLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSR 304
L I +A V+ ++HAI+++SP Y PG A L LP + D+ R
Sbjct: 306 FLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKR 365
Query: 305 Y 305
+
Sbjct: 366 H 366
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 139 bits (350), Expect = 3e-33
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 9/295 (3%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACF--TEEGSQKLQRDTSYRLQTTLLDV 80
++ + V ITGCDSGFG AK+L G VLA G+ +L+ S RL+ +D+
Sbjct: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
Query: 81 TKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEV 140
TK I ++ + GLW LVNNAG E F + VN G +E+
Sbjct: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
Query: 141 TLHMLPMVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGVKVCI 199
T +LP+++ +RGR+V + S G + G Y SK V D+ EL +GVKV I
Sbjct: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
Query: 200 IEPGNYRT-AILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVAEPRVR 258
I+PG ++T ++ E R + L LPQE +YG+DY + + +++A +
Sbjct: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
Query: 259 DVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP-----VTDFILSRYLPR 308
V++++ A+++ PR RY PG L+Y LP + F +S LPR
Sbjct: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPR 374
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 84.7 bits (208), Expect = 9e-17
Identities = 83/278 (29%), Positives = 122/278 (43%), Gaps = 26/278 (9%)
Query: 28 VFITGCDSGFGNLLAKQLVD---RGMQVLAACFTEEGSQKLQRDTSYRLQTTL----LDV 80
V I+GC SG G LA QL + QV+A + L+ L TL LDV
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67
Query: 81 TKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEV 140
ES+ ++ +V LVNNAG+GL GP E L+ V + N G + +
Sbjct: 68 CSDESVAQCLSCIQGEVD-----VLVNNAGMGLV-GPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 141 TLHMLPMVKRAR-GRVVNMSSSGGRVAVIGGG-YCVSKFGVEAFSDSIRRELYYFGVKVC 198
+LP +KR R G +V +SS G VI Y SKF +E F +S+ +L F + +
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 199 IIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR-IYTDKLKNIMQVAEPRV 257
++EPG T GK + M + P+ YFR +Y + +
Sbjct: 182 LVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLH------YFRDLYLPASRKLFCSVGQNP 235
Query: 258 RDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPT 295
+DV+ ++ + I S P +R + Y PL L T
Sbjct: 236 QDVVQAIVNVISSTRPPLR----RQTNIRYSPLTTLKT 269
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 84.0 bits (206), Expect = 2e-16
Identities = 82/267 (30%), Positives = 121/267 (45%), Gaps = 25/267 (9%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTE----------EGSQKLQRDTSYR 72
++ V ITGC SG G LA +L Q T E ++ L
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG-S 59
Query: 73 LQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINV 132
L+T LDV S+S+ AA R++V E + LV NAG+GL GP E L +D V++V
Sbjct: 60 LETLQLDVRDSKSVAAA----RERVTEGRVDVLVCNAGLGL-LGPLEALGEDAVASVLDV 114
Query: 133 NLVGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRREL 190
N+VG + + LP M +R GRV+ S GG + + YC SKF +E +S+ L
Sbjct: 115 NVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLL 174
Query: 191 YYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIM 250
FGV + +IE G TA + E + ++ +R D + F Y K +
Sbjct: 175 LPFGVHLSLIECGPVHTAFM--EKVLGSPEEVLDR-----TDIHTFHRFYQYLAHSKQVF 227
Query: 251 QVAEPRVRDVINSMEHAIVSRSPRIRY 277
+ A +V A+ + P +RY
Sbjct: 228 REAAQNPEEVAEVFLTALRAPKPTLRY 254
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 70.1 bits (170), Expect = 2e-12
Identities = 70/278 (25%), Positives = 139/278 (50%), Gaps = 28/278 (10%)
Query: 6 DLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKL 65
DL+ ++ ++ L++ V++TG SG G LA QL G+ ++ + +++
Sbjct: 31 DLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERV 90
Query: 66 QR----DTSYRLQTTL---LDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPN 118
+R + + + + L LD+T + S +AA + V + G + LVNN G+ S
Sbjct: 91 KRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCM 148
Query: 119 EWLTKDDFVKVINVNLVGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSK 176
+ + D + K+I +N +G + +T +LP M++R +G++V ++S G ++V + GYC SK
Sbjct: 149 D-TSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASK 207
Query: 177 FGVEAFSDSIRREL-YYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYG 235
+ F + +R EL Y G+ V I PG ++ I+ + +L + K T + G
Sbjct: 208 HALRGFFNGLRTELATYPGIIVSNICPGPVQSNIV-ENSLAGEVTK--------TIGNNG 258
Query: 236 EDYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSP 273
+ ++ T + +M ++ + N ++ +S P
Sbjct: 259 DQSHKMTTSRCVRLMLIS------MANDLKEVWISEQP 290
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 69.7 bits (169), Expect = 3e-12
Identities = 61/197 (30%), Positives = 93/197 (47%), Gaps = 16/197 (8%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGS-----QKLQRDTSYRLQT-- 75
L V ITG SG G AK G + L C G+ ++L + ++QT
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAK-LVLCGRNGGALEELIRELTASHATKVQTHK 108
Query: 76 ---TLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINV 132
D+T S +I AAA + G + LVNNAG+ G T D +V+
Sbjct: 109 PYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LVNNAGISY-RGTIMDTTVDVDKRVMET 165
Query: 133 NLVGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRREL 190
N G + +T +LP M+KR +G +V +SS G++++ Y SK +AF D +R E+
Sbjct: 166 NYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEM 225
Query: 191 YYFGVKVCIIEPGNYRT 207
+ ++V +I PG T
Sbjct: 226 EQYEIEVTVISPGYIHT 242
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 68.6 bits (166), Expect = 7e-12
Identities = 51/185 (27%), Positives = 90/185 (48%), Gaps = 4/185 (2%)
Query: 26 KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSES 85
K V +TG G G + + V+ G +V+ E G + L+++ + L DVT+ +
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
Query: 86 IKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLHML 145
+K + G L +VNNAG P E + F +++ +NL+G +T L
Sbjct: 69 VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
Query: 146 PMVKRARGRVVNMSSSGGRVAVIGG-GYCVSKFGVEAFSDSIRRELYYFGVKVCIIEPGN 204
P +++++G V+N+SS G + Y +K V A + ++ + +GV+V I PGN
Sbjct: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGN 186
Query: 205 YRTAI 209
T +
Sbjct: 187 IWTPL 191
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 67.8 bits (164), Expect = 1e-11
Identities = 65/235 (27%), Positives = 107/235 (45%), Gaps = 24/235 (10%)
Query: 17 CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFT----EEGSQKLQRDT-SY 71
C L K V ITG ++G G A++L RG +V AC E + +++ DT +
Sbjct: 31 CRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNS 90
Query: 72 RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131
++ LD++ ++SI+A A+ + E+ L L+NNAGV + T D F +
Sbjct: 91 QVLVRKLDLSDTKSIRAFAEGFLAE--EKQLHILINNAGVMMCPYSK---TADGFETHLG 145
Query: 132 VNLVGLIEVTLHMLPMVK-RARGRVVNMSSSGGRVAVI-------------GGGYCVSKF 177
VN +G +T +L +K A RVVN+SS + I G YC SK
Sbjct: 146 VNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKL 205
Query: 178 GVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRD 232
F+ + + L GV + PG R+ ++ +L + +L+ + R+
Sbjct: 206 ANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTARE 260
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 67.8 bits (164), Expect = 1e-11
Identities = 67/230 (29%), Positives = 102/230 (44%), Gaps = 35/230 (15%)
Query: 17 CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTT 76
C L K V +TG ++G G AK+L RG +V AC E + + ++ +QTT
Sbjct: 33 CTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKE----IQTT 88
Query: 77 L---------LDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFV 127
LD++ ++SI+A A+ + E+ L L+NNAGV + T D F
Sbjct: 89 TGNQQVLVRKLDLSDTKSIRAFAKGFLAE--EKHLHVLINNAGVMMCPYSK---TADGFE 143
Query: 128 KVINVNLVGLIEVTLHMLPMVKR-ARGRVVNMSS-------------SGGRVAVIGGGYC 173
I VN +G +T +L +K A R+VN+SS G + G YC
Sbjct: 144 MHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYC 203
Query: 174 VSKFGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLW 223
SK F+ + R L GV + PG ++ ++ S MR +W
Sbjct: 204 HSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV---RHSSFMRWMW 250
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 65.1 bits (157), Expect = 8e-11
Identities = 57/213 (26%), Positives = 91/213 (42%), Gaps = 25/213 (11%)
Query: 17 CNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRD-----TSY 71
C + K V +TG ++G G A +L RG ++ AC E + +D ++
Sbjct: 30 CPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNH 89
Query: 72 RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131
+ LD+ +SI+ A + ++ E+ + L+NNAGV W T+D F
Sbjct: 90 HVNARHLDLASLKSIREFAAKIIEE--EERVDILINNAGV---MRCPHWTTEDGFEMQFG 144
Query: 132 VNLVGLIEVTLHMLPMVK-RARGRVVNMSSSGGRVAVIG--------------GGYCVSK 176
VN +G +T +L +K A R++N+SS I YC SK
Sbjct: 145 VNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSK 204
Query: 177 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAI 209
+ F+ + R L GV V + PG RT +
Sbjct: 205 LAIVLFTKELSRRLQGSGVTVNALHPGVARTEL 237
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 14/198 (7%)
Query: 22 NLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQ---KLQRDT-SYRLQTTL 77
N++ + V ITG SG G LLA Q G ++ +EG++ K+ R+ + R+
Sbjct: 37 NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYT 96
Query: 78 LDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFV-KVINVNLVG 136
D ++ E + A V+ +VG+ + L+NNAG+ +G D+ + K +VN
Sbjct: 97 CDCSQKEGVYRVADQVKKEVGDVSI--LINNAGI--VTGKKFLDCPDELMEKSFDVNFKA 152
Query: 137 LIEVTLHMLP-MVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELY--- 191
+ LP M+ G +V +SSS G V G YC SKF F++S+ E +
Sbjct: 153 HLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQK 212
Query: 192 YFGVKVCIIEPGNYRTAI 209
G+K I+ P +T +
Sbjct: 213 QKGIKTTIVCPFFIKTGM 230
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 62.4 bits (150), Expect = 5e-10
Identities = 60/211 (28%), Positives = 94/211 (44%), Gaps = 23/211 (10%)
Query: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
+ L L F Y W N + +L V +TG ++G G LA G ++ TE
Sbjct: 6 LTGLGALFFAYYWDDNFD-PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEA 64
Query: 61 GSQKL----QRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG 116
QK+ ++ + ++ D+ E+ ++ Q+ DK+G GL LV N G P+G
Sbjct: 65 LLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLG--GLDYLVLNHIGGAPAG 122
Query: 117 PN-------EWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAV-I 168
WL + VN V +++T LP + ++G +V +SS GRV
Sbjct: 123 TRARSPQATRWL--------MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSF 174
Query: 169 GGGYCVSKFGVEAFSDSIRRELYYFGVKVCI 199
Y +KF ++ F S+RREL V V I
Sbjct: 175 STPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 62.4 bits (150), Expect = 5e-10
Identities = 60/211 (28%), Positives = 94/211 (44%), Gaps = 23/211 (10%)
Query: 1 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60
+ L L F Y W N + +L V +TG ++G G LA G ++ TE
Sbjct: 6 LTGLGALFFAYYWDDNFD-PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEA 64
Query: 61 GSQKL----QRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG 116
QK+ ++ + ++ D+ E+ ++ Q+ DK+G GL LV N G P+G
Sbjct: 65 LLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLG--GLDYLVLNHIGGAPAG 122
Query: 117 PN-------EWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAV-I 168
WL + VN V +++T LP + ++G +V +SS GRV
Sbjct: 123 TRARSPQATRWL--------MQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSF 174
Query: 169 GGGYCVSKFGVEAFSDSIRRELYYFGVKVCI 199
Y +KF ++ F S+RREL V V I
Sbjct: 175 STPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 61.6 bits (148), Expect = 9e-10
Identities = 64/210 (30%), Positives = 93/210 (44%), Gaps = 23/210 (10%)
Query: 22 NLSEKYVFITGCDSGFGNLLAKQLVDRGMQV-LAACFTEEGSQ-KLQRDTSYRLQTTLL- 78
+++ K +TG G G A+ L+ +G +V L E G Q K D + Q TL
Sbjct: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
Query: 79 --DVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
DV + ++ + V D G L LVNNAGV + ++ K + +NLV
Sbjct: 62 QCDVADQQQLRDTFRKVVDHFGR--LDILVNNAGVN---------NEKNWEKTLQINLVS 110
Query: 137 LIEVTLHMLPMVKRARGR----VVNMSSSGGRVAVIGGG-YCVSKFGVEAF--SDSIRRE 189
+I T L + + G ++NMSS G + V YC SK G+ F S ++
Sbjct: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
Query: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRM 219
L GV++ I PG TAIL E M
Sbjct: 171 LMNSGVRLNAICPGFVNTAILESIEKEENM 200
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 58.5 bits (140), Expect = 7e-09
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 26/209 (12%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQK-------LQRDTSYRLQT 75
L K V +TG G G +A L G V+ ++E QK L +++ +
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
Query: 76 TLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV---INV 132
T+ D+T +E A A + GL L+ N L DD V + V
Sbjct: 92 TMEDMTFAEQFVAQAGKLMG-----GLDMLILNHITNTSLN----LFHDDIHHVRKSMEV 142
Query: 133 NLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELY 191
N + + +T+ LPM+K++ G +V +SS G+VA + Y SKF ++ F SIR+E
Sbjct: 143 NFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYS 202
Query: 192 YFGVKVCIIEPGNYRTAILGKENLESRMR 220
V V I +LG + E+ M+
Sbjct: 203 VSRVNVSI------TLCVLGLIDTETAMK 225
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 58.5 bits (140), Expect = 7e-09
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 26/209 (12%)
Query: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQK-------LQRDTSYRLQT 75
L K V +TG G G +A L G V+ ++E QK L +++ +
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAG 91
Query: 76 TLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV---INV 132
T+ D+T +E A A + GL L+ N L DD V + V
Sbjct: 92 TMEDMTFAEQFVAQAGKLMG-----GLDMLILNHITNTSLN----LFHDDIHHVRKSMEV 142
Query: 133 NLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELY 191
N + + +T+ LPM+K++ G +V +SS G+VA + Y SKF ++ F SIR+E
Sbjct: 143 NFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYS 202
Query: 192 YFGVKVCIIEPGNYRTAILGKENLESRMR 220
V V I +LG + E+ M+
Sbjct: 203 VSRVNVSI------TLCVLGLIDTETAMK 225
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 30 ITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAA 89
ITG SG G A++LV +G + G + + DVT + ++ A
Sbjct: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
Query: 90 AQWVRDKVGEQGLWALVNNAGVGLPSGP-----NEWLTKDDFVKVINVNLVGLIEVTLHM 144
+ K G + VN AG+ + S + T +DF +V++VNL+G V +
Sbjct: 75 LALAKGKFGRVDV--AVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLV 132
Query: 145 L-------PMVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELYYFGVK 196
P RG ++N +S +G Y SK G+ + I R+L G++
Sbjct: 133 AGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIR 192
Query: 197 VCIIEPGNYRTAIL 210
V I PG + T +L
Sbjct: 193 VMTIAPGLFGTPLL 206
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 57.8 bits (138), Expect = 1e-08
Identities = 52/214 (24%), Positives = 105/214 (49%), Gaps = 16/214 (7%)
Query: 27 YVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTL---LD 79
+V +TG SG G +A + +G + E+ ++++ + Q L +D
Sbjct: 34 HVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVD 93
Query: 80 VTKS-ESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLI 138
V++ ++ + ++K+G + LVN AG+ + SG E L F +++++N +G +
Sbjct: 94 VSQDYNQVENVIKQAQEKLGPVDM--LVNCAGMAV-SGKFEDLEVSTFERLMSINYLGSV 150
Query: 139 EVTLHMLPMVKRAR-GRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELYYFGVK 196
+ ++ +K R GR+V +SS G++ + G Y SKF + +++++ E+ + V
Sbjct: 151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVY 210
Query: 197 VCIIEPGNYRTAILGKENLESRMRKLWERLPQET 230
+ + P + T +EN R + L RL ET
Sbjct: 211 ITVAYPPDTDTPGFAEEN---RTKPLETRLISET 241
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 57.4 bits (137), Expect = 2e-08
Identities = 50/187 (26%), Positives = 95/187 (50%), Gaps = 15/187 (8%)
Query: 26 KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSES 85
++ +TG G G A++L GM+V+ +++ ++ + + + T++ +
Sbjct: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE----TRTIA 106
Query: 86 IKAAAQWVRDKV--GEQGL--WALVNNAGVGLPSGPNEWLTKDD----FVKVINVNLVGL 137
+ A++ + DK+ G GL LVNN G+ P +L D K+IN+N++ +
Sbjct: 107 VDFASEDIYDKIKTGLAGLEIGILVNNVGMSY-EYPEYFLDVPDLDNVIKKMININILSV 165
Query: 138 IEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGV 195
++T +LP MV+R++G ++N+SS G + V + Y +K V+ FS + E GV
Sbjct: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGV 225
Query: 196 KVCIIEP 202
V + P
Sbjct: 226 FVQSVLP 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,389,137
Number of Sequences: 37866
Number of extensions: 483838
Number of successful extensions: 1133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 1048
Number of HSP's gapped (non-prelim): 70
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.