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Search of human proteins with 224586855
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
(492 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 1020 0.0
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 993 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 982 0.0
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 961 0.0
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 873 0.0
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 873 0.0
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 555 e-158
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 555 e-158
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 408 e-114
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 408 e-114
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 384 e-107
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 384 e-107
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 340 1e-93
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 257 1e-68
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 240 2e-63
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 228 7e-60
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 218 8e-57
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 108 8e-24
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 101 1e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 101 1e-21
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 96 1e-19
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 91 2e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 88 2e-17
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 87 3e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 87 3e-17
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 84 3e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 84 3e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 84 3e-16
gi|11321634 CD2-associated protein [Homo sapiens] 83 5e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 83 7e-16
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 1020 bits (2637), Expect = 0.0
Identities = 492/492 (100%), Positives = 492/492 (100%)
Query: 1 MKATTPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAA 60
MKATTPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAA
Sbjct: 1 MKATTPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAA 60
Query: 61 KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 120
KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD
Sbjct: 61 KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 120
Query: 121 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 180
TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP
Sbjct: 121 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 180
Query: 181 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 240
AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD
Sbjct: 181 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 240
Query: 241 MGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 300
MGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR
Sbjct: 241 MGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 300
Query: 301 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 360
VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL
Sbjct: 301 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 360
Query: 361 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 420
KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK
Sbjct: 361 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 420
Query: 421 PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF
Sbjct: 421 PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
Query: 481 FGTFPGNYVKRL 492
FGTFPGNYVKRL
Sbjct: 481 FGTFPGNYVKRL 492
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 993 bits (2567), Expect = 0.0
Identities = 484/503 (96%), Positives = 484/503 (96%), Gaps = 19/503 (3%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 159 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 218
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 219 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 278
Query: 129 RSIFEYEPGKSSILQHERP-------------------ASLYQSSIDRSLERPMSSASMA 169
RSIFEYEPGKSSILQHERP ASLYQSSIDRSLERPMSSASMA
Sbjct: 279 RSIFEYEPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMA 338
Query: 170 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 229
SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE
Sbjct: 339 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE 398
Query: 230 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID 289
SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID
Sbjct: 399 SPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID 458
Query: 290 QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL 349
QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL
Sbjct: 459 QNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVEL 518
Query: 350 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS 409
SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS
Sbjct: 519 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYS 578
Query: 410 SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG 469
SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG
Sbjct: 579 SDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDG 638
Query: 470 WFVGTSRRTKFFGTFPGNYVKRL 492
WFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 639 WFVGTSRRTKFFGTFPGNYVKRL 661
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 982 bits (2539), Expect = 0.0
Identities = 484/531 (91%), Positives = 484/531 (91%), Gaps = 47/531 (8%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 136 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 195
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 196 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 255
Query: 129 RSIFEYEPGKSSILQHERP----------------------------------------- 147
RSIFEYEPGKSSILQHERP
Sbjct: 256 RSIFEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHS 315
Query: 148 ------ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 201
ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV
Sbjct: 316 SGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV 375
Query: 202 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 261
DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK
Sbjct: 376 DLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAK 435
Query: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 321
AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA
Sbjct: 436 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 495
Query: 322 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 381
RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF
Sbjct: 496 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIF 555
Query: 382 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 441
PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL
Sbjct: 556 PVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQAL 615
Query: 442 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 616 YNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 961 bits (2483), Expect = 0.0
Identities = 469/484 (96%), Positives = 469/484 (96%), Gaps = 15/484 (3%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 176 TVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAAKTQTYRPL 220
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 221 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 280
Query: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 188
RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 281 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 340
Query: 189 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 248
GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE
Sbjct: 341 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 400
Query: 249 RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY 308
RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY
Sbjct: 401 RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISY 460
Query: 309 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 368
VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY
Sbjct: 461 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 520
Query: 369 EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH 428
EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH
Sbjct: 521 EGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTH 580
Query: 429 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 488
ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY
Sbjct: 581 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNY 640
Query: 489 VKRL 492
VKRL
Sbjct: 641 VKRL 644
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 873 bits (2256), Expect = 0.0
Identities = 452/556 (81%), Positives = 457/556 (82%), Gaps = 72/556 (12%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 269 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 328
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPV-----------------PPLRPRD-------- 103
SKSHSDNSPNAFKDASSPVPPPHVPPPV PP R D
Sbjct: 329 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388
Query: 104 ---------RSSTEKHDWDPPDRKVDT-------RKFRSE-------------PRSIFEY 134
+SS +H+ PP T RK S PRS
Sbjct: 389 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 448
Query: 135 EPGKSSILQHERP------------------ASLYQSSIDRSLERPMSSASMASDFRKRR 176
++ L RP ASLYQSSIDRSLERPMSSASMASDFRKRR
Sbjct: 449 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 508
Query: 177 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 236
KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS
Sbjct: 509 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 568
Query: 237 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 296
TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE
Sbjct: 569 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 628
Query: 297 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 356
HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR
Sbjct: 629 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 688
Query: 357 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 416
VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL
Sbjct: 689 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 748
Query: 417 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 476
SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR
Sbjct: 749 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 808
Query: 477 RTKFFGTFPGNYVKRL 492
RTKFFGTFPGNYVKRL
Sbjct: 809 RTKFFGTFPGNYVKRL 824
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 873 bits (2256), Expect = 0.0
Identities = 452/556 (81%), Positives = 457/556 (82%), Gaps = 72/556 (12%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 176 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 235
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPV-----------------PPLRPRD-------- 103
SKSHSDNSPNAFKDASSPVPPPHVPPPV PP R D
Sbjct: 236 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 295
Query: 104 ---------RSSTEKHDWDPPDRKVDT-------RKFRSE-------------PRSIFEY 134
+SS +H+ PP T RK S PRS
Sbjct: 296 RSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPT 355
Query: 135 EPGKSSILQHERP------------------ASLYQSSIDRSLERPMSSASMASDFRKRR 176
++ L RP ASLYQSSIDRSLERPMSSASMASDFRKRR
Sbjct: 356 PSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR 415
Query: 177 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 236
KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS
Sbjct: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
Query: 237 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 296
TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE
Sbjct: 476 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 535
Query: 297 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 356
HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR
Sbjct: 536 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
Query: 357 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 416
VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL
Sbjct: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 655
Query: 417 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 476
SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR
Sbjct: 656 SSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 715
Query: 477 RTKFFGTFPGNYVKRL 492
RTKFFGTFPGNYVKRL
Sbjct: 716 RTKFFGTFPGNYVKRL 731
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 170 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 225
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 677 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 735
Query: 226 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 283
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 736 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 795
Query: 284 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 343
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 796 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 855
Query: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 403
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 856 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 915
Query: 404 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 463
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 975
Query: 464 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 976 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 429 bits (1102), Expect = e-120
Identities = 223/283 (78%), Positives = 231/283 (81%), Gaps = 26/283 (9%)
Query: 1 MKATTPLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAA 60
MKATTPLQTVDRPKDWYKTMFKQIHMVHKP GLYNPPYSAQSHPAA
Sbjct: 1 MKATTPLQTVDRPKDWYKTMFKQIHMVHKP---------------GLYNPPYSAQSHPAA 45
Query: 61 KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 120
KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD
Sbjct: 46 KTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD 105
Query: 121 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 180
TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP
Sbjct: 106 TRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 165
Query: 181 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 240
AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK + + S +
Sbjct: 166 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSY 225
Query: 241 MGRSAPRERRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 279
G + G P E L + Y D + + +SFK G
Sbjct: 226 SGLN------GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 261
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 555 bits (1429), Expect = e-158
Identities = 281/329 (85%), Positives = 288/329 (87%), Gaps = 7/329 (2%)
Query: 170 SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVD---LPGSSTTLTKSFTSSSPSSPSRA- 225
S R R+S P P L A P + D +P S++ +SS R
Sbjct: 773 SSLRALRRS-PLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGG 831
Query: 226 --KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 283
+DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY
Sbjct: 832 ALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVY 891
Query: 284 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 343
ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA
Sbjct: 892 ILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNA 951
Query: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 403
DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP
Sbjct: 952 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPP 1011
Query: 404 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 463
IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVM 1071
Query: 464 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
EKCDDGWFVGTSRRTKFFGTFPGNYVKRL
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 457 bits (1176), Expect = e-128
Identities = 230/275 (83%), Positives = 238/275 (86%), Gaps = 11/275 (4%)
Query: 9 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 68
TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL
Sbjct: 90 TVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPL 149
Query: 69 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 128
SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP
Sbjct: 150 SKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209
Query: 129 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 188
RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL
Sbjct: 210 RSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGL 269
Query: 189 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE 248
GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK + + S + G +
Sbjct: 270 GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLN---- 325
Query: 249 RRGTPEKEKLPAKAVY----DFKAQTSKELSFKKG 279
G P E L + Y D + + +SFK G
Sbjct: 326 --GNPSSE-LDYCSTYRQHLDVPRDSPRAISFKNG 357
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 408 bits (1048), Expect = e-114
Identities = 233/492 (47%), Positives = 311/492 (63%), Gaps = 34/492 (6%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 352 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 405
Query: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 406 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 451
Query: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 452 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 509
Query: 185 PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRS 244
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 510 LTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLES 563
Query: 245 APRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 303
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGI
Sbjct: 564 TEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGI 623
Query: 304 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 363
FP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++V
Sbjct: 624 FPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
Query: 364 DQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQ 422
D+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q
Sbjct: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
Query: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 743 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 802
Query: 481 FGTFPGNYVKRL 492
FGTFPGNYVK L
Sbjct: 803 FGTFPGNYVKPL 814
Score = 39.3 bits (90), Expect = 0.008
Identities = 97/476 (20%), Positives = 165/476 (34%), Gaps = 72/476 (15%)
Query: 56 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 115
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 190 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 234
Query: 116 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS---------IDRSLERPMSSA 166
D+ +E S + +P+S Y S+ + + E+ +
Sbjct: 235 VSSTDSSPLLNEVSSSL-IGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLS 293
Query: 167 SMASDFRKRRKSE----PAVGPPRGLG-----------------DQSASRTSPGRVDLPG 205
S++ +RR E P P G Q S S V +P
Sbjct: 294 SLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPL 353
Query: 206 SSTTLTKS-----FTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTP--EKEKL 258
+T +K F + D SPR S T S PR + + EK+
Sbjct: 354 RNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKV 413
Query: 259 PAK-AVYDFKAQTSK-ELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 316
+ A A++S + S ++ D +K+D Y E P + E
Sbjct: 414 VKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGK--SSVLTNE 471
Query: 317 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
K A P P E I NF+A E GD L ++ Y+ + G
Sbjct: 472 KMSSAISPTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSL--ENERQIYKSVLEG-- 526
Query: 377 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 436
G P+ + +K+ + A H +D + S +R H++ +
Sbjct: 527 --GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR----HDDKE--MR 578
Query: 437 PFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
P +A +++ + EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 579 PARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 632
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 408 bits (1048), Expect = e-114
Identities = 233/492 (47%), Positives = 311/492 (63%), Gaps = 34/492 (6%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 220 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 273
Query: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 274 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 319
Query: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 377
Query: 185 PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRS 244
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 378 LTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLES 431
Query: 245 APRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 303
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGI
Sbjct: 432 TEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGI 491
Query: 304 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 363
FP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++V
Sbjct: 492 FPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 550
Query: 364 DQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQ 422
D+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q
Sbjct: 551 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 610
Query: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 611 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 670
Query: 481 FGTFPGNYVKRL 492
FGTFPGNYVK L
Sbjct: 671 FGTFPGNYVKPL 682
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 384 bits (987), Expect = e-107
Identities = 231/542 (42%), Positives = 316/542 (58%), Gaps = 78/542 (14%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 220 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 273
Query: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 274 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 319
Query: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 377
Query: 185 PRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------------ 223
L ++ S G + L G S S ++S+ S S
Sbjct: 378 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR 437
Query: 224 -RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------P 253
R D+E + R ++ + + ER G
Sbjct: 438 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS 497
Query: 254 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 313
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 498 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP 557
Query: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IP
Sbjct: 558 PAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 616
Query: 374 GTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
GT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 617 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 676
Query: 433 GGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK
Sbjct: 677 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
Query: 491 RL 492
L
Sbjct: 737 PL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 384 bits (987), Expect = e-107
Identities = 231/542 (42%), Positives = 316/542 (58%), Gaps = 78/542 (14%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 261 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 314
Query: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 315 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 360
Query: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 418
Query: 185 PRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------------ 223
L ++ S G + L G S S ++S+ S S
Sbjct: 419 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR 478
Query: 224 -RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------P 253
R D+E + R ++ + + ER G
Sbjct: 479 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS 538
Query: 254 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 313
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 539 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP 598
Query: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IP
Sbjct: 599 PAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 657
Query: 374 GTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
GT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 658 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 717
Query: 433 GGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK
Sbjct: 718 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
Query: 491 RL 492
L
Sbjct: 778 PL 779
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 340 bits (873), Expect = 1e-93
Identities = 231/612 (37%), Positives = 314/612 (51%), Gaps = 148/612 (24%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 315 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 368
Query: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 369 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 414
Query: 126 SEP-------------------------------------------------RSIFEYEP 136
+EP + I++Y P
Sbjct: 415 AEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTP 474
Query: 137 GKSSILQHE-RPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA- 193
G SIL E R +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 475 GDCSILPREDRKSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQI 532
Query: 194 --SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE--- 229
S G + L G S S ++S+ S S R D+E
Sbjct: 533 YKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLL 592
Query: 230 ---------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAV 263
+ R ++ + + ER G E PA+A
Sbjct: 593 ADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 652
Query: 264 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 323
+DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +
Sbjct: 653 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKL 712
Query: 324 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPV 383
P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP+
Sbjct: 713 TP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
Query: 384 SYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQ 422
+YV+V+K+ K DY D P S S HSL + + Q
Sbjct: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
Query: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
Query: 481 FGTFPGNYVKRL 492
FGTFPGNYVK L
Sbjct: 892 FGTFPGNYVKPL 903
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 257 bits (657), Expect = 1e-68
Identities = 183/552 (33%), Positives = 268/552 (48%), Gaps = 87/552 (15%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPY-SAQSHPAAK--- 61
P +VDRP+DWY+ MF+QIH PD D +T+ +P + AQ PA +
Sbjct: 136 PRSSVDRPRDWYRRMFQQIHR-KMPDLQLD-----WTFEEPPRDPRHLGAQQRPAHRPGP 189
Query: 62 TQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST--EKHDWDPPDRKV 119
+ S HS+ P + + + P LR R++ + W+ +++
Sbjct: 190 ATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQEL 249
Query: 120 DTRKFRSEPRSIFEYEPGKSSI----LQHERPASLYQSSID---RSLERPMSSASMASDF 172
+T + P+ +PG+ + ER + + +D R++E + S +
Sbjct: 250 ETGQ---RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAP 306
Query: 173 RKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR 232
R+ + P GP SA +S GS+ +L+ + S +D P
Sbjct: 307 RRAPEQRPPAGPA------SAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPS 360
Query: 233 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW 292
S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+NW
Sbjct: 361 STRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 417
Query: 293 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR 352
EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS R
Sbjct: 418 LEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELSFR 476
Query: 353 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNTKG 395
KG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 477 KGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 536
Query: 396 AEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG--------- 435
A P P + S D I P+R F+ +N+ G
Sbjct: 537 ARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP 596
Query: 436 ------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRR 477
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG SRR
Sbjct: 597 SHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRR 656
Query: 478 TKFFGTFPGNYV 489
T+ FGTFPGNYV
Sbjct: 657 TQKFGTFPGNYV 668
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 240 bits (612), Expect = 2e-63
Identities = 186/565 (32%), Positives = 255/565 (45%), Gaps = 162/565 (28%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
PL+ +R KDWYKTMFKQIH +++ + + Y Y + S + +P T +
Sbjct: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQF 443
Query: 66 ---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP-----------------PVPPL 99
P KS D+S + +D SP+ P P+P
Sbjct: 444 PASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPAR 503
Query: 100 RPRDRSSTEKHDWDPPDRKVDTR------------------------------------- 122
+SS+E++DW+PPD+KVDTR
Sbjct: 504 SSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLK 563
Query: 123 -----KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSSIDRSLER-- 161
KF SE P+ I++Y PG SIL E + SL Q+ ++ LE+
Sbjct: 564 NEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKME 623
Query: 162 ----------PMSSASM--------------ASDFRK-RRKSEPAVGPPRGLGDQSA--- 193
P SSA +S+F +R+S+ A G L ++
Sbjct: 624 TLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 683
Query: 194 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE----- 229
S G + L G S S ++S+ S S R D+E
Sbjct: 684 SVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLAD 743
Query: 230 -------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYD 265
+ R ++ + + ER G E PA+A +D
Sbjct: 744 QRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 803
Query: 266 FKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPP 325
FKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P
Sbjct: 804 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP 863
Query: 326 PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 385
Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++Y
Sbjct: 864 -VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITY 922
Query: 386 VEVVKKN-TKGAEDYPDPPIPHSYS 409
V+V+K+ K DY D P S S
Sbjct: 923 VDVIKRPLVKNPVDYMDLPFSSSPS 947
Score = 102 bits (254), Expect = 8e-22
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 438 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 210 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-----KAVY 264
L +F S R + E ++ + ++RR TP++ + +A+Y
Sbjct: 1181 LGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALY 1240
Query: 265 DFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 312
+ Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 1241 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 38.1 bits (87), Expect = 0.018
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 228 bits (582), Expect = 7e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 226 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 285
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
Query: 286 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 345
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
Query: 346 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 390
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
Query: 391 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 435
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
Query: 436 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 470
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
Query: 471 FVGTSRRTKFFGTFPGNYV 489
FVG SRRT+ FGTFPGNYV
Sbjct: 308 FVGVSRRTQKFGTFPGNYV 326
Score = 69.7 bits (169), Expect = 6e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 308 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 367
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Query: 368 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 427
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
Query: 428 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 487
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
Query: 488 YVK 490
YV+
Sbjct: 167 YVQ 169
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 192 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 245
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
Query: 246 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 303
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
Query: 304 FPISYV 309
FP +YV
Sbjct: 321 FPGNYV 326
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 218 bits (556), Expect = 8e-57
Identities = 174/541 (32%), Positives = 246/541 (45%), Gaps = 155/541 (28%)
Query: 31 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 90
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 476 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 525
Query: 91 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTR---------------------------- 122
+SS+E++DW+PPD+KVDTR
Sbjct: 526 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 576
Query: 123 --------------KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSS 154
KF SE P+ I++Y PG SIL E + SL Q+
Sbjct: 577 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTE 636
Query: 155 IDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPRG 187
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 637 LEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 696
Query: 188 LGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RA 225
L ++ S G + L G S S ++S+ S S R
Sbjct: 697 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 756
Query: 226 KDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKE 256
D+E + R ++ + + ER G E
Sbjct: 757 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 816
Query: 257 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPE 316
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P E
Sbjct: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 876
Query: 317 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
KAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+
Sbjct: 877 KAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
Query: 377 RQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 435
RQGIFP++YV+V+K+ K DY D P S S S + + + + +G G
Sbjct: 936 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAG 995
Query: 436 E 436
E
Sbjct: 996 E 996
Score = 148 bits (373), Expect = 1e-35
Identities = 105/298 (35%), Positives = 146/298 (48%), Gaps = 49/298 (16%)
Query: 231 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 290
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 865 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 924
Query: 291 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPP------ 325
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 925 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Query: 326 ---------PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
+ G G I+K + ++V L R+ D N E PG
Sbjct: 985 QYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLS-----DLNTPEESRPGKP 1039
Query: 377 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 436
FP S E +++ G + ++ R S QR V T + Q +
Sbjct: 1040 LGSAFPGSEAEQTERHRGGEQ-------AGRKAARRGGSQQPQAQQRRV-TPDRSQTSQD 1091
Query: 437 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1092 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/189 (31%), Positives = 89/189 (47%), Gaps = 48/189 (25%)
Query: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPY--------------TYNAGLYNPP 51
PL+ +R KDWYKTMFKQIH +++ + + Y Y T + + +P
Sbjct: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPR 443
Query: 52 YSA--------------QSHPAAKTQTYRPLSKSHSD-NSP--NAFKDASSPVPPPH--- 91
S+P + SD SP + +D SP+ P
Sbjct: 444 LECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKS 503
Query: 92 --------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 137
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 504 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 563
Query: 138 KSSILQHER 146
KSS+L +E+
Sbjct: 564 KSSVLTNEK 572
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 108 bits (271), Expect = 8e-24
Identities = 99/417 (23%), Positives = 173/417 (41%), Gaps = 52/417 (12%)
Query: 88 PPPHVPP--PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHE 145
PP VPP P PP R S +K ++ +D +K +S + KS + +++
Sbjct: 338 PPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ 395
Query: 146 RPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 205
P RP + S + + P G+ ++ +PG +
Sbjct: 396 DPVLP---------PRPKPGHPLYSKYM--------LSVPHGIANEDIVSQNPGELSCKR 438
Query: 206 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 259
+ T ++ + +D S +T + R R P + P
Sbjct: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
Query: 260 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 316
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
Query: 317 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
Query: 377 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 436
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
Query: 437 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
Score = 84.3 bits (207), Expect = 2e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
Query: 375 TNRQGIFPVSYVEVVK 390
+ GIFP +Y++ ++
Sbjct: 775 --KSGIFPKNYIQFLQ 788
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 101 bits (252), Expect = 1e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 318
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
Query: 319 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 378
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
Query: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 437
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
Query: 438 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
Score = 84.3 bits (207), Expect = 2e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
Query: 375 TNRQGIFPVSYVEVVK 390
+ GIFP +Y++ ++
Sbjct: 716 --KSGIFPKNYIQFLQ 729
Score = 72.8 bits (177), Expect = 7e-13
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 276 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 332
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 377 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436
Query: 333 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 390
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494
Query: 391 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 450
+G + H R A + Y +D
Sbjct: 495 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529
Query: 451 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 490
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 530 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 101 bits (252), Expect = 1e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 318
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
Query: 319 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 378
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
Query: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 437
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
Query: 438 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
Score = 84.3 bits (207), Expect = 2e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
Query: 375 TNRQGIFPVSYVEVVK 390
+ GIFP +Y++ ++
Sbjct: 752 --KSGIFPKNYIQFLQ 765
Score = 73.9 bits (180), Expect = 3e-13
Identities = 87/395 (22%), Positives = 157/395 (39%), Gaps = 62/395 (15%)
Query: 115 PDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK 174
P RK + ++P +P L E+P S++ L + ++ S+
Sbjct: 252 PTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPG 311
Query: 175 RRKS---EPAVGPPRGLG------DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 225
+ P PPR + Q ++ P R P S T + P + S +
Sbjct: 312 QTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSAT--RRSNKKLPFNRS-S 368
Query: 226 KDRESPRSYSSTLTDMGRSAPRERRGT----PEKEKLPAKAVYDFKAQTSKELSFKKGDT 281
D + + S+ T + ++ + + P + K P +Y + +GD
Sbjct: 369 SDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPK-PGHPLYS---------KYMRGDV 418
Query: 282 VYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAI 336
+ +L++ + N+ E GE GRV + + + L +++P P +P + G A+
Sbjct: 419 LVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV 478
Query: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 396
++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+ +G
Sbjct: 479 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGG 536
Query: 397 EDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRE 456
+ H R A + Y +DEL E
Sbjct: 537 NGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKDELSFSE 571
Query: 457 SDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 490
++I + E ++ W G R RT G FP N+V+
Sbjct: 572 GEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 95.5 bits (236), Expect = 1e-19
Identities = 66/206 (32%), Positives = 106/206 (51%), Gaps = 26/206 (12%)
Query: 205 GSSTTLTKSFTS-SSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLP---- 259
GS T T + S SS + +KD +S + G PR + +P +P
Sbjct: 88 GSGTNCTNALRSQSSTVANCSSKDLQSSQ---------GGQQPRVQSWSPPVRGIPQLPC 138
Query: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
AKA+Y+++ + +L F KGD + + R++D+NWY GE +G G FP ++V+ + P
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKP----- 193
Query: 320 PARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 379
P PP Q + + K + AD + L K D + +++RVD+NW EG + ++ G
Sbjct: 194 --LPQPPPQCKALYDFEVK-DKEADKDC-LPFAKDDVLTVIRRVDENWAEGML--ADKIG 247
Query: 380 IFPVSYVEVVKKNTKGAEDYPDPPIP 405
IFP+SYVE K ++ PP+P
Sbjct: 248 IFPISYVE-FNSAAKQLIEWDKPPVP 272
Score = 72.0 bits (175), Expect = 1e-12
Identities = 31/52 (59%), Positives = 37/52 (71%)
Query: 438 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 489
+ A+Y YTPR EDELELR+ ++ V E+C DGWF GTS T G FPGNYV
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 55.8 bits (133), Expect = 9e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
E + + +Y P++E ELEL+E D++ V +K +DGWF GT +R G FPG++V+ +
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 44.7 bits (104), Expect = 2e-04
Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 336 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 395
+A Y + EL LRKG+ ++ +R W++G T++ G+FP +YV V T+
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV---TRA 507
Query: 396 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGG 435
+ +P S + ++ P + +QG G
Sbjct: 508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 46/216 (21%)
Query: 203 LPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDM-GRSAPRERRGTPEKEKLPAK 261
LPG T+ S +S+ +S + D++S + L + G S R+ R +P PA
Sbjct: 686 LPGLPTS-PDSASSACGNSSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSP-----PAS 739
Query: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPI--------------- 306
+ + S EL + + G HGR G P+
Sbjct: 740 PTLEVELG-SAELPLQGA--------VGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAAL 790
Query: 307 ---SYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK------------YNFNADTNVELSL 351
++ K + + A P PPP +G + + ++ + EL L
Sbjct: 791 AQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELEL 850
Query: 352 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
++GD V + K+ + W++G + + G+FP S+VE
Sbjct: 851 KEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.7 bits (104), Expect = 2e-04
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 312
+ V + Q+ EL K+GD V++ +K + W++G + +G+ G+FP S+VE +
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 39.3 bits (90), Expect = 0.008
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLT 313
A+Y + + EL +KG+ + + W++G H ++G+FP +YV +T
Sbjct: 452 AIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVT 505
Score = 34.7 bits (78), Expect = 0.20
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+ALYNY + +L+ + D+I + + D+ W+ G G FP N+V+
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHG--EVNGIHGFFPTNFVQ 189
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 90.9 bits (224), Expect = 2e-18
Identities = 73/261 (27%), Positives = 110/261 (42%), Gaps = 34/261 (13%)
Query: 261 KAVYDF----KAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVE------ 310
KA+YDF K Q L+F K + + +LR++D+NW EG ++GIFP+ YVE
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 311 KLTPPEKAQPARPPP-----PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 365
+L +K PA P+ G + ++ V R+ D K+
Sbjct: 322 QLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS 381
Query: 366 NW-----YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 420
+ ++R + + V + + + A D + H + +SS+
Sbjct: 382 FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGD--LAHLSCAAPTQDVSSSA 439
Query: 421 PQRPVFTHENIQGGGEP------------FQALYNYTPRNEDELELRESDVIDVMEKCDD 468
P GE + ALY Y P+ DELEL + ++ V+EKC D
Sbjct: 440 GSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQD 499
Query: 469 GWFVGTSRRTKFFGTFPGNYV 489
GWF G S RT G FPGNYV
Sbjct: 500 GWFKGASLRTGVSGVFPGNYV 520
Score = 89.7 bits (221), Expect = 5e-18
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 45/248 (18%)
Query: 173 RKRRKSEPAVGPP-RGLGDQSASRTSPG-----RVDLPGSSTTLTKSFTSSSPSSPSRAK 226
R R + P PP R + QSA+ T G PGS L+ + S++ S A
Sbjct: 124 RPRAGTSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELAT 183
Query: 227 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 286
R +P + + L G KA+Y ++ + +L F KGD + + R
Sbjct: 184 SRTAPAAKNPCLLPYG------------------KALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 287 KIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTN 346
K+D+ WY GE HG G P SY++ + P A P + A Y+F
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP-------------QGKALYDFEMKDK 272
Query: 347 VE----LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDP 402
+ L+ K + + +L+RVD+NW EG + ++ GIFP+ YVE+ + E D
Sbjct: 273 DQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIGIFPLLYVELNDSAKQLIE--MDK 328
Query: 403 PIPHSYSS 410
P P + SS
Sbjct: 329 PCPAAASS 336
Score = 54.7 bits (130), Expect = 2e-07
Identities = 22/55 (40%), Positives = 39/55 (70%)
Query: 436 EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
E ++ + +Y P++E E+EL+E D++ V +K +DGW+ GT +R G FPG++V+
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/140 (30%), Positives = 62/140 (44%), Gaps = 19/140 (13%)
Query: 215 TSSSPSSPSRAKD----------RESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAK-- 261
+SS P + +R D ++ S ST T + R+A +GTP K +LP
Sbjct: 410 SSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVY 469
Query: 262 -AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYVEKLTPPEKA 318
A+Y +K Q S EL KG+ +L K W++G G G+FP +YV TP +
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV---TPVSRV 526
Query: 319 QPARPPPPAQPGEIGEAIAK 338
PP G +AK
Sbjct: 527 PAGGAGPPRNNVVGGSPLAK 546
Score = 50.8 bits (120), Expect = 3e-06
Identities = 67/290 (23%), Positives = 109/290 (37%), Gaps = 49/290 (16%)
Query: 53 SAQSHPAAKTQTYRP---LSKSHSDNSPNAFKDAS----SPVPPPHVPPPVPPLRPRDRS 105
S +H AA+ Q RP +S + NSP+ S S V P H P + PR
Sbjct: 608 STAAHSAAQAQD-RPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAI 666
Query: 106 --STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPM 163
++ PP+ V E G +L P + ++ E+
Sbjct: 667 PLTSAASAITPPN--VSAANLNGEAGG------GPIGVLSTSSPTNTGCKLDEKKSEKKE 718
Query: 164 SSASM-----ASDFRKRRKSEPAVGPPR------------GLGDQSASRTSPGRVDLPGS 206
+ + + +K+ +S P+V P +G + +S + GR
Sbjct: 719 KKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRA----G 774
Query: 207 STTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT-PEKEKLPA---KA 262
S + + P K S T R AP PE + LP +
Sbjct: 775 SCPIESEMQGAMGMEPLHRK----AGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRV 830
Query: 263 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVE 310
V + Q+ E+ K+GD V++ +K + WY+G + +GR G+FP S+VE
Sbjct: 831 VVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.5 bits (114), Expect = 1e-05
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 294 EGEHHGRVGIFPI-----SYVEKLTPPEKAQPA-----RPPPPAQPGEIGEAIAKYNFNA 343
E E G +G+ P+ S T P + P RP P P E + Y +
Sbjct: 779 ESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQS 838
Query: 344 DTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
+ +EL ++GD V + K+ + WY+G + R G+FP S+VE
Sbjct: 839 EAEIEL--KEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/76 (27%), Positives = 34/76 (44%)
Query: 325 PPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVS 384
PP + +A Y + + EL L KG+ +L++ W++G T G+FP +
Sbjct: 459 PPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGN 518
Query: 385 YVEVVKKNTKGAEDYP 400
YV V + G P
Sbjct: 519 YVTPVSRVPAGGAGPP 534
Score = 34.3 bits (77), Expect = 0.27
Identities = 15/52 (28%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+ALY+Y + +L+ + D+I + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)
Query: 266 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 315
++AQ ELS GD V +R + + W GE GR G+FP V+++
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 316 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 370
+ PA+ P P + ++ ++++ + EL L+ G+ V ++K ++ W+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
Query: 371 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 428
K G + G FP ++VE++ + PD P P ++ SL+ + P + T
Sbjct: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 429 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 486
+ E ++ L++Y P DEL LR DV+ V+ K D GW+ G + + G FP
Sbjct: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
Query: 487 NYV 489
N+V
Sbjct: 235 NFV 237
Score = 72.0 bits (175), Expect = 1e-12
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)
Query: 249 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 305
RRG P K P K + + + + EL + G+ V ++++I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 306 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 342
++VE L PP P P P P +P ++ +++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 343 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 386
+ EL+LR+GD V +L + D+ W+EG+ G R+G+FP ++V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
Score = 59.7 bits (143), Expect = 6e-09
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)
Query: 334 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 392
E + + A ELSL GD V ++ V + W G+ G R G+FP V+ + +
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 393 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 452
+G+ + P R H +PQR + ++Y+P DEL
Sbjct: 60 LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
Query: 453 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
+L+ ++++++++ +DGW++G ++ G FP N+V+ L
Sbjct: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
Score = 50.1 bits (118), Expect = 5e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)
Query: 218 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 277
+P PS + + P SS D +P + T ++ + ++D++ + EL+ +
Sbjct: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
Query: 278 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 322
+GD V +L K D+ W+EGE GR G+FP ++V P +K P +
Sbjct: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 3e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 222 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 280
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 281 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 326
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 327 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 385
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 386 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 445
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 446 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 492
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 321
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 322 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 378
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 438
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 238 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 297
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 298 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 351
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 352 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 388
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 2e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 263 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 1e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 313
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 374 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 432
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 433 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 487
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 488 YVK 490
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.3
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 438 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 491 RL 492
++
Sbjct: 803 KI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 87.0 bits (214), Expect = 3e-17
Identities = 83/290 (28%), Positives = 135/290 (46%), Gaps = 54/290 (18%)
Query: 222 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK-EKLPAKAVYDFKAQTSKELSFKKGD 280
PS + R+ +T T S+P G EK E L A+A+Y ++A+ L+F K D
Sbjct: 882 PSAGQLRQRSAFTPATATG---SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 281 TVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP----------EKAQPAR----PPPP 326
+ +L + D W+ GE G+ G FP SYV+ ++ P PA P
Sbjct: 939 VITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPA 997
Query: 327 AQPGEIGEA-IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 385
A+P GE IA Y + + +L+ ++GD VIL+ + D +W+ G + ++ G+FP +Y
Sbjct: 998 AKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTVG--DKAGVFPSNY 1054
Query: 386 VEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYT 445
V + K+++G S ++ + SL KP E Q + +YT
Sbjct: 1055 VRL--KDSEG-----------SGTAGKTGSLGK-KP--------------EIAQVIASYT 1086
Query: 446 PRNEDELELRESDVIDVMEKCDDGWFVGTSR---RTKFFGTFPGNYVKRL 492
++L L +I + +K GW+ G + + + G FP NYVK L
Sbjct: 1087 ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 84.7 bits (208), Expect = 2e-16
Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 33/232 (14%)
Query: 262 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPA 321
A+Y +++ +L+F++GD + + +K D +W+ G + G+FP +YV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 322 RPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP--GTNRQ- 378
+ + EI + IA Y A +L+L G +++ K+ W+EG++ G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYT--ATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF 438
G FP +YV+++ T ++ +P + Q G
Sbjct: 1126 GWFPANYVKLLSPGTS--------------------KITPTEPPKSTALAAVCQVIG--- 1162
Query: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
+Y+YT +N+DEL + +I+V+ K D W+ G G FP NYVK
Sbjct: 1163 --MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ--VGLFPSNYVK 1210
Score = 75.5 bits (184), Expect = 1e-13
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 238 LTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 297
L D S + G+ K+ A+ + + A ++L+ G + I +K W+EGE
Sbjct: 1057 LKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGEL 1116
Query: 298 HGR-----VGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL 351
R +G FP +YV+ L+P K P PP + + I Y++ A + EL+
Sbjct: 1117 QARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF 1176
Query: 352 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 388
KG + +L + D +W++G++ G + G+FP +YV++
Sbjct: 1177 NKGQIINVLNKEDPDWWKGEVNG--QVGLFPSNYVKL 1211
Score = 57.8 bits (138), Expect = 2e-08
Identities = 24/57 (42%), Positives = 39/57 (68%)
Query: 263 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
+YD+ AQ EL+F KG + +L K D +W++GE +G+VG+FP +YV+ T + +Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 55.5 bits (132), Expect = 1e-07
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 34/243 (13%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRK-IDQN------WYEGEHHGRVGIFPISYVEKLT 313
+A+Y F++++ E++ + GD V + + +D++ W GE G+ G FP +Y EK+
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
E P +P + + + +T L++ + NW
Sbjct: 806 ENEVPAPVKPVTDSTSAPAPKLALR-----ETPAPLAVTSSEP----STTPNNW------ 850
Query: 374 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHEN-IQ 432
+ +P S E K T + + P S+ ++ S+ P + + +
Sbjct: 851 -ADFSSTWPTSTNE--KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL 907
Query: 433 GGGEPF-----QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 487
G GE QALY + + ++ L ++DVI V+E+ D WF G + K G FP +
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQK--GWFPKS 964
Query: 488 YVK 490
YVK
Sbjct: 965 YVK 967
Score = 32.0 bits (71), Expect = 1.3
Identities = 16/62 (25%), Positives = 31/62 (50%), Gaps = 9/62 (14%)
Query: 438 FQALYNYTPRNEDELELRESDV-------IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
++ALY + R+ DE+ ++ D+ +D + + GW G + G FP NY +
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT--GWFPANYAE 802
Query: 491 RL 492
++
Sbjct: 803 KI 804
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 84.0 bits (206), Expect = 3e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 177 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 234
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 793 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 852
Query: 235 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 294
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 853 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 909
Query: 295 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 344
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 910 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 968
Query: 345 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 399
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 969 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1025
Query: 400 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 439
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1026 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1085
Query: 440 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 478
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1086 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1145
Query: 479 KFFGTFPGNYVK 490
G FP NYVK
Sbjct: 1146 T--GLFPSNYVK 1155
Score = 74.3 bits (181), Expect = 2e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 219 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 278
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1003 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1049
Query: 279 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 332
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1102
Query: 333 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 392
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1103 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1160
Query: 393 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
DP + ++ + +R + HE IQ
Sbjct: 1161 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1192
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 204 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 260
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1049 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1105
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1106 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 46.6 bits (109), Expect = 5e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 318
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 319 QPARPPPPAQP 329
+ P P
Sbjct: 796 KAVSPKKALLP 806
Score = 43.9 bits (102), Expect = 3e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 438 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 492
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 789
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 84.0 bits (206), Expect = 3e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 177 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 234
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 235 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 294
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 295 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 344
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 345 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 399
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 400 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 439
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 440 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 478
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 479 KFFGTFPGNYVK 490
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 2e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 219 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 278
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 279 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 332
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 333 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 392
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 393 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 204 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 260
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 5e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 318
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 319 QPARPPPPAQP 329
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 3e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 438 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 492
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 84.0 bits (206), Expect = 3e-16
Identities = 94/372 (25%), Positives = 153/372 (41%), Gaps = 67/372 (18%)
Query: 177 KSEPAVGPPRGL--GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSY 234
++E AV P + L S S TS L + + + S S+ + + ++
Sbjct: 820 ENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAF 879
Query: 235 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 294
+ T++ G +P +G E L A+A+ + A+ L+F K D + +L + +NW+
Sbjct: 880 TRTVSP-GSVSPIHGQGQVV-ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWF 936
Query: 295 GEHHGRVGIFPISYVEKLTPPEKAQPARPP---------PPAQPGEIGEA-IAKYNFNAD 344
GE HG G FP SYV K+ P + + P P + +GE IA Y +++
Sbjct: 937 GEVHGGRGWFPKSYV-KIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSV 995
Query: 345 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV-----EVVKKNTKGAEDY 399
+L+ +G+ +++ ++ D W+ G I +R GIFP +YV E +K
Sbjct: 996 EPGDLTFTEGEEILVTQK-DGEWWTGSIG--DRSGIFPSNYVKPKDQESFGSASKSGASN 1052
Query: 400 PDPPIPH---SYSSDRIHSLSSNKPQRPVFTHEN--------IQGGGEPFQ--------- 439
P I +Y + LS Q + +N +Q G+ Q
Sbjct: 1053 KKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHV 1112
Query: 440 ---------------------ALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRT 478
A+Y+Y NEDEL + +I+VM K D W+ G
Sbjct: 1113 KLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV 1172
Query: 479 KFFGTFPGNYVK 490
G FP NYVK
Sbjct: 1173 T--GLFPSNYVK 1182
Score = 74.3 bits (181), Expect = 2e-13
Identities = 61/220 (27%), Positives = 101/220 (45%), Gaps = 36/220 (16%)
Query: 219 PSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKK 278
PS+ + KD+ES S S + G K+ A+ + A S++LS
Sbjct: 1030 PSNYVKPKDQESFGSASKS-------------GASNKKPEIAQVTSAYVASGSEQLSLAP 1076
Query: 279 GDTVYILRKIDQNWYEGEHHGR-----VGIFPISYVEKLTPP-EKAQPARPPPPAQPGEI 332
G + IL+K W++GE R G FP S+V+ L P E+A PA P +
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------V 1129
Query: 333 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN 392
+ IA Y++ A+ ELS KG + ++ + D +W++G+I G G+FP +YV++ +
Sbjct: 1130 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVKMTTDS 1187
Query: 393 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
DP + ++ + +R + HE IQ
Sbjct: 1188 --------DPSQQWCADLQTLDTMQPIERKRQGYIHELIQ 1219
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 204 PGSSTTLTKSFTSS--SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKL-PA 260
PG + K TS +R K R+ +S + +G P R TP +
Sbjct: 1076 PGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG---PSSERATPAFHPVCQV 1132
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQ 319
A+YD+ A ELSF KG + ++ K D +W++GE +G G+FP +YV+ T + +Q
Sbjct: 1133 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 46.6 bits (109), Expect = 5e-05
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 261 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 318
+A+Y F+A+ E+SF GD + + K + W G G G FP +YVEK+ E
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 319 QPARPPPPAQP 329
+ P P
Sbjct: 823 KAVSPKKALLP 833
Score = 43.9 bits (102), Expect = 3e-04
Identities = 22/57 (38%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 438 FQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPGNYVKRL 492
++ALY + RN DE+ D+I V EK + GW G+ + FG FP NYV+++
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGN--FGWFPCNYVEKM 816
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 83.2 bits (204), Expect = 5e-16
Identities = 53/165 (32%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 336 IAKYNFNADTNVELSLRKGDRVILLKRV-DQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 394
I +Y+++A + EL++R G+ + +K++ ++ W EG++ G R+G+FP ++V+ +K+ T+
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRETE 62
Query: 395 GAED-YPDPPIPHSYSSDRIHSLSS-NKPQRPVFTH---ENIQGGGEPFQA--LYNYTPR 447
+D P H + + +S+ P + H +NI+ + Q L+ Y P+
Sbjct: 63 FKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQ 122
Query: 448 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
NEDELEL+ D+ID+ E+ ++GW+ GT G FP N+VK L
Sbjct: 123 NEDELELKVGDIIDINEEVEEGWWSGTLNNK--LGLFPSNFVKEL 165
Score = 55.8 bits (133), Expect = 9e-08
Identities = 65/325 (20%), Positives = 128/325 (39%), Gaps = 100/325 (30%)
Query: 264 YDFKAQTSKELSFKKGDTVYILRKI-DQNWYEGEHHGRVGIFPISYVEKL-TPPEKAQPA 321
YD+ A EL+ + G+ + ++K+ ++ W EGE +GR G+FP ++V+++ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 322 RPPPPAQPGEIGEAIAK--------------------------------YNFNADTNVEL 349
P + G + + + + + EL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 350 SLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG----AED------- 398
L+ GD + + + V++ W+ G + N+ G+FP ++V+ ++ G A+D
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTL--NNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLA 185
Query: 399 YPDPPIP---------------------------HSYSSDRIHSLSSN------KPQRPV 425
P PIP S ++ + +S+ KP++P+
Sbjct: 186 GPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPL 245
Query: 426 -------------FTHENIQG---GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CD 467
T + +G E + L+ Y NEDEL +E ++I ++ K +
Sbjct: 246 ILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGE 305
Query: 468 DGWFVGTSRRTKFFGTFPGNYVKRL 492
GW+ G + G FP N+ ++
Sbjct: 306 AGWWRGELNGKE--GVFPDNFAVQI 328
Score = 50.8 bits (120), Expect = 3e-06
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 5/88 (5%)
Query: 255 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKL 312
K K + ++ ++ EL+FK+G+ ++++ K + W+ GE +G+ G+FP ++ ++
Sbjct: 269 KAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Query: 313 TPPEK--AQPARPPPPAQ-PGEIGEAIA 337
+K +P +PPPPA+ P E IA
Sbjct: 329 NELDKDFPKPKKPPPPAKAPAPKPELIA 356
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 82.8 bits (203), Expect = 7e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 334 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 393
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 394 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 450
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
Query: 451 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
Score = 66.2 bits (160), Expect = 6e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 255 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 312
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
Query: 313 TPP----EKAQPARPPPPAQP 329
PP E +P +PPPP+ P
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP 346
Score = 63.5 bits (153), Expect = 4e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 264 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 323
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 324 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 359
P +P + GE + +++ + EL L+ GD + +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 360 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
+ V++ W+EG + G + G+FP ++++
Sbjct: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
Score = 62.4 bits (150), Expect = 9e-10
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 215 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 274
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
Query: 275 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 334
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
Query: 335 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 394
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
Query: 395 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 454
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
Query: 455 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 492
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 47.8 bits (112), Expect = 2e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 339 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 396
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
Query: 397 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 448
+ P P P S +++R H + P+RP P + P
Sbjct: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
Query: 449 EDELELRESDV 459
E +L+L++ V
Sbjct: 385 EPKLDLQKPSV 395
Score = 34.7 bits (78), Expect = 0.20
Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)
Query: 77 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 134
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
Query: 135 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 194
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
Query: 195 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 254
R ++DL GSS + S S+ + +S S + L+ S P+ P
Sbjct: 433 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 492
Query: 255 KEKLPAKAV 263
+ L + ++
Sbjct: 493 SQSLTSSSL 501
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,416,037
Number of Sequences: 37866
Number of extensions: 1392649
Number of successful extensions: 14024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 303
Number of HSP's successfully gapped in prelim test: 515
Number of HSP's that attempted gapping in prelim test: 10016
Number of HSP's gapped (non-prelim): 3745
length of query: 492
length of database: 18,247,518
effective HSP length: 106
effective length of query: 386
effective length of database: 14,233,722
effective search space: 5494216692
effective search space used: 5494216692
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.