Guide to the Human Genome
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Name: POLE3 Sequence: fasta or formatted (147aa) NCBI GI: 224586804
Description:

DNA-directed DNA polymerase epsilon 3

Referenced in:

DNA Polymerases
Nonhistone Chromosomal Proteins
RNA Polymerase and General Transcription Factors

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine            10.2         15           2
 C cysteine            0.7          1           1
 D aspartate           8.2         12           1
 E glutamate          17.7         26           4
 F phenylalanine       2.7          4           1
 G glycine             2.0          3           1
 H histidine           0.0          0           0
 I isoleucine          3.4          5           2
 K lysine             10.9         16           3
 L leucine             6.1          9           1
 M methionine          2.7          4           1
 N asparagine          6.1          9           2
 P proline             2.7          4           1
 Q glutamine           3.4          5           1
 R arginine            6.8         10           2
 S serine              6.8         10           1
 T threonine           3.4          5           1
 V valine              4.8          7           1
 W tryptophan          0.0          0           0
 Y tyrosine            1.4          2           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   DNA-directed DNA polymerase epsilon 3 
NFYB                  0.188   nuclear transcription factor Y, beta 
DR1                   0.134   down-regulator of transcription 1 
LOC645490             0.115   PREDICTED: similar to hCG1991922 
CALR                  0.111   calreticulin precursor 
LOC100289089          0.100   PREDICTED: hypothetical protein XP_002343359 
LOC645490             0.096   PREDICTED: similar to hCG1991922 
MYT1                  0.096   myelin transcription factor 1 
HMGB1                 0.096   high-mobility group box 1 
LOC645490             0.096   PREDICTED: similar to hCG1991922 
LOC100294088          0.092   PREDICTED: hypothetical protein, partial 
MYT1L                 0.088   myelin transcription factor 1-like 
CLSPN                 0.088   claspin 
HMGB2                 0.084   high-mobility group box 2 
HMGB2                 0.084   high-mobility group box 2 
HMGB2                 0.084   high-mobility group box 2 
LOC728792             0.084   PREDICTED: hypothetical protein 
BAZ2B                 0.084   bromodomain adjacent to zinc finger domain, 2B [Homo...
RANGAP1               0.080   Ran GTPase activating protein 1 
NCL                   0.080   nucleolin 
CCDC136               0.080   coiled-coil domain containing 136 
LOXHD1                0.077   lipoxygenase homology domains 1 isoform 1 
HMGB1L1               0.077   high-mobility group box 1-like 1 
C12orf12              0.077   hypothetical protein LOC196477 
CCAR1                 0.073   cell-cycle and apoptosis regulatory protein 1 
TBC1D10B              0.073   TBC1 domain family, member 10B 
ATAD2                 0.073   ATPase family, AAA domain containing 2 
YTHDC1                0.073   splicing factor YT521-B isoform 2 
KIF21B                0.073   kinesin family member 21B 
YTHDC1                0.073   splicing factor YT521-B isoform 1 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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