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Search of human proteins with 223005922
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223005922 leucine rich repeat containing 10-like [Homo
sapiens]
(292 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 585 e-167
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 192 3e-49
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 113 2e-25
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 106 3e-23
gi|45827729 scribble isoform b [Homo sapiens] 105 4e-23
gi|45827731 scribble isoform a [Homo sapiens] 105 4e-23
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 105 4e-23
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 104 1e-22
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 104 1e-22
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 100 2e-21
gi|238908508 leucine-rich repeat and death domain-containing pro... 98 8e-21
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 94 1e-19
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 92 4e-19
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 92 4e-19
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 92 4e-19
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 88 8e-18
gi|61742786 leucine rich repeat and death domain containing prot... 87 2e-17
gi|61742784 leucine rich repeat and death domain containing prot... 87 2e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 83 3e-16
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 82 4e-16
gi|197333706 leucine rich repeat containing 8 family, member D [... 82 6e-16
gi|34222199 leucine rich repeat containing 8 family, member D [H... 82 6e-16
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 82 6e-16
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 82 7e-16
gi|40217803 leucine rich repeat containing 8 family, member E [H... 80 2e-15
gi|61742782 leucine rich repeat and death domain containing prot... 78 8e-15
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 74 1e-13
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 74 2e-13
gi|62241040 leucine rich repeat containing 8 family, member A [H... 74 2e-13
gi|187829877 leucine rich repeat containing 8 family, member A [... 74 2e-13
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 585 bits (1507), Expect = e-167
Identities = 292/292 (100%), Positives = 292/292 (100%)
Query: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP 60
MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP
Sbjct: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP 60
Query: 61 EEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWI 120
EEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWI
Sbjct: 61 EEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWI 120
Query: 121 EGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR 180
EGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR
Sbjct: 121 EGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR 180
Query: 181 MGRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAER 240
MGRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAER
Sbjct: 181 MGRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAER 240
Query: 241 DEPTPRPPPRRPARAFEDEEEEDLLIGGAGSRALGAPGGSFRALEAAPGLGT 292
DEPTPRPPPRRPARAFEDEEEEDLLIGGAGSRALGAPGGSFRALEAAPGLGT
Sbjct: 241 DEPTPRPPPRRPARAFEDEEEEDLLIGGAGSRALGAPGGSFRALEAAPGLGT 292
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 192 bits (488), Expect = 3e-49
Identities = 107/243 (44%), Positives = 144/243 (59%), Gaps = 9/243 (3%)
Query: 23 DQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERL 82
D+ ++LSG +LRR P VC+ L KLY+S L LP E+ +L+ L+ILALDFN + L
Sbjct: 31 DKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKAL 90
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P +C L +L LYLG N+L LP++ + LQ+LR LWIE N L + P + L L++L
Sbjct: 91 PQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLH 150
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHP 202
G N LR LP +L R+ LR +WL GNR +FP LL M L ++D+D N + FP L
Sbjct: 151 AGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAH 210
Query: 203 LRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAERDEPTPRPPPRRPAR-AFEDEEE 261
L +L++ YDHNP P+VA V VG A E TP P PR+ R A EE
Sbjct: 211 LSSLKLVIYDHNPCRNAPKVAKGVRRVGRWA--------EETPEPDPRKARRYALVREES 262
Query: 262 EDL 264
++L
Sbjct: 263 QEL 265
Score = 53.9 bits (128), Expect = 2e-07
Identities = 39/121 (32%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 10 ELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELREL 69
+LPS E L + L + L +LP VC LS L+ L+ LR LP ++ L+EL
Sbjct: 112 DLPS--ELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQEL 169
Query: 70 RILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFP 129
R + L N+L P L +P L + + N + P+ A L SL+ + + N R P
Sbjct: 170 RTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS-LAHLSSLKLVIYDHNPCRNAP 228
Query: 130 R 130
+
Sbjct: 229 K 229
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 113 bits (283), Expect = 2e-25
Identities = 70/177 (39%), Positives = 99/177 (55%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L LS +L LP+ + AL+ L++L VS L LP+ + L LR L +D N+L P
Sbjct: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
L +L L L + NRL LP D + L++L+ LW+ G L P L +L+SL +
Sbjct: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDL 200
+N L+ALPA+ + L+ L L N FEEFP ALL + L L L RN+L P L
Sbjct: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL 314
Score = 108 bits (269), Expect = 7e-24
Identities = 69/196 (35%), Positives = 99/196 (50%), Gaps = 1/196 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++ +L P + L L++L VS LR LPE+I LR L+IL L +L LP G
Sbjct: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
C L L L L N L ALPA F+ LQ L+ L + N FP LL L L+ L +
Sbjct: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSR 305
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPLR 204
N+L ++P+ + + L LWL NR P +++ + L L L N++ PD L
Sbjct: 306 NQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLS 365
Query: 205 ALRVFSYDHNPVTGPP 220
+ ++ NP+ PP
Sbjct: 366 RVGLWKIKDNPLIQPP 381
Score = 99.4 bits (246), Expect = 3e-21
Identities = 71/175 (40%), Positives = 86/175 (49%), Gaps = 2/175 (1%)
Query: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEI-EELRELRILALDFNKLERLP 83
L L R RLP AV L L +L VS L L E+ LRELR L L N+L LP
Sbjct: 92 LVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALP 151
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
L L L L + NRL LP + L LR L ++ N L FPR LL+LVAL+ L +
Sbjct: 152 AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDV 211
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
NRLR LP ++ + L+ LWL G P + L L LD N L P
Sbjct: 212 SSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALP 266
Score = 96.3 bits (238), Expect = 3e-20
Identities = 61/176 (34%), Positives = 88/176 (50%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L++S RL LP ++ LSRL+ L V L P ++ +L L L + N+L LP
Sbjct: 161 EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP 220
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ + L L L+L G L LPA F +L SL L ++ N L+ P L L+ L +
Sbjct: 221 EDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNL 280
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
N PA L + GL L+L N+ P + +GRL L LD NR+ PD
Sbjct: 281 SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPD 336
Score = 83.2 bits (204), Expect = 2e-16
Identities = 64/170 (37%), Positives = 89/170 (52%), Gaps = 4/170 (2%)
Query: 43 LSRLQKLYVSGTGLRELPEEI-EELRELRILALDFNKLERLPDGLCRL-PRLTRLYLGGN 100
L ++ L + GL E+PE + L LR+L L N+ RLP + L LT L + N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 101 RLLALPAD-FAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMT 159
RL AL A+ + L+ LR L + N L P L L L+ L + NRL LP L ++
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181
Query: 160 GLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLRALRV 208
LR L + N+ FP LL++ L LD+ NRL G P D+ LRAL++
Sbjct: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Score = 58.5 bits (140), Expect = 7e-09
Identities = 37/106 (34%), Positives = 53/106 (50%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+ L LS P+A+ L+ L++LY+S L +P I L L L LD N++ LP
Sbjct: 276 KMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLP 335
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFP 129
D + L L L L GN++ LP F QL + I+ N L + P
Sbjct: 336 DSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
Score = 56.2 bits (134), Expect = 3e-08
Identities = 49/176 (27%), Positives = 72/176 (40%), Gaps = 24/176 (13%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L LSG L LP+ C L+ L+ L + GL+ LP + L+ L++L L N E P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 86 LCRLP-----------------------RLTRLYLGGNRLLALPADFAQLQSLRCLWIEG 122
L L RL L+L NR+ LP +L L L ++G
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 123 NFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
N + P +L + ++ DN L P E+ M G+ + Y PA+
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAYQKELAHSQPAV 406
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/86 (33%), Positives = 45/86 (52%)
Query: 21 SGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLE 80
+G ++L LS +L +PS + L RL L++ +R LP+ I EL L L L N++
Sbjct: 296 AGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIA 355
Query: 81 RLPDGLCRLPRLTRLYLGGNRLLALP 106
LPD +L R+ + N L+ P
Sbjct: 356 VLPDHFGQLSRVGLWKIKDNPLIQPP 381
Score = 43.5 bits (101), Expect = 2e-04
Identities = 32/87 (36%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 138 LQSLQMGDNRLRALPAELPRMTG-LRGLWLYGNRFEEFPPALLRMG-RLHILDLDRNRLG 195
+++L +G+N L +P L G LR L L NRF PPA+ +G L LD+ NRL
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 196 --GFPDLHPLRALRVFSYDHNPVTGPP 220
G + LR LR + HN + P
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALP 151
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 106 bits (264), Expect = 3e-23
Identities = 57/171 (33%), Positives = 96/171 (56%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L + L LP+ + +L L++L +S G++E PE I+ + L I+ N + +LP
Sbjct: 72 RKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLP 131
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
DG +L LT+LYL L LPA+F +L LR L + N L+ P+ + +L L+ L +
Sbjct: 132 DGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDL 191
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
G+N LP L ++ LR LW+ N + P ++ ++ L LD+ +NR+
Sbjct: 192 GNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRI 242
Score = 87.8 bits (216), Expect = 1e-17
Identities = 56/174 (32%), Positives = 87/174 (50%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
+E S + +LP L L +LY++ L LP L +LRIL L N L+ LP
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ +L +L RL LG N LP Q+Q+LR LW++ N L+ P + +L L L M
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK 239
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
NR+ + ++ L L L N ++ P ++ + +L L +D N+L P+
Sbjct: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPN 293
Score = 78.2 bits (191), Expect = 8e-15
Identities = 50/173 (28%), Positives = 87/173 (50%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
LEL L+ LP ++ L++L++L + ELPE +++++ LR L +D N L+ LP
Sbjct: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGS 225
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ +L L L + NR+ + D + ++L L + N L++ P + L L +L++ D
Sbjct: 226 IGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDD 285
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
N+L LP + ++ L N E P + + L L +D N L P
Sbjct: 286 NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
Score = 77.8 bits (190), Expect = 1e-14
Identities = 51/168 (30%), Positives = 83/168 (49%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S R+ + + L+ L +S L++LP+ I L++L L +D N+L LP+
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNT 294
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L L N L +LP+ L SLR L ++ NFL PR + + + +
Sbjct: 295 IGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRS 354
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
N+L LP E+ +M LR L L NR + P + ++ L L L N+
Sbjct: 355 NKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
Score = 74.7 bits (182), Expect = 9e-14
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 2/191 (1%)
Query: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
L+ S L+++P V R L++LY+ + ELP+++ + LR L++ N L LP
Sbjct: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+ L L L + N + P + + L + N + + P +L+ L L +
Sbjct: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
D L LPA R+ LR L L N + P ++ ++ +L LDL N G P+ L +
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
Query: 204 RALRVFSYDHN 214
+ LR D+N
Sbjct: 207 QNLRELWMDNN 217
Score = 69.3 bits (168), Expect = 4e-12
Identities = 50/175 (28%), Positives = 81/175 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L + L+ LP ++ L L L +S + + +I L L L N L++LP
Sbjct: 210 RELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP 269
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
D + L +LT L + N+L LP L L N L P + L +L++L +
Sbjct: 270 DSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAV 329
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+N L LP E+ + + L N+ E P + +M +L +L+L NRL P
Sbjct: 330 DENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 64.3 bits (155), Expect = 1e-10
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 1/198 (0%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
QL L+ L LP+ L +L+ L + L+ LP+ + +L +L L L N+ LP+
Sbjct: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
L ++ L L++ N L LP +L+ L L + N + + AL+ L +
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLS 261
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
N L+ LP + + L L + N+ P + + L D N L P + L
Sbjct: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
Query: 204 RALRVFSYDHNPVTGPPR 221
+LR + D N + PR
Sbjct: 322 HSLRTLAVDENFLPELPR 339
Score = 63.9 bits (154), Expect = 2e-10
Identities = 36/100 (36%), Positives = 54/100 (54%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++ + S L LPS + L L+ L V L ELP EI + + +++L NKLE LP
Sbjct: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 361
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
+ + ++ +L L L NRL LP F +L+ L LW+ N
Sbjct: 362 EEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 105 bits (263), Expect = 4e-23
Identities = 67/175 (38%), Positives = 87/175 (49%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L LS ++RLP V +L +L VS + E+PE I+ + L I N L RLP
Sbjct: 62 RKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
DG +L L L L L ALP D L +L L + N L+ P L LV L+ L +
Sbjct: 122 DGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
G N L LP L + LR LWL N+ PP L + RL LD+ NRL P
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Score = 93.2 bits (230), Expect = 2e-19
Identities = 63/168 (37%), Positives = 84/168 (50%)
Query: 27 ELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGL 86
+ SG L RLP L L L ++ L+ LP ++ L L L L N L+ LP L
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 87 CRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDN 146
L +L +L LGGN L LP L +LR LW++ N L P L L L L + +N
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 147 RLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
RL LPAEL + L L L N P + ++ +L IL +D+NRL
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 90.9 bits (224), Expect = 1e-18
Identities = 68/198 (34%), Positives = 87/198 (43%), Gaps = 23/198 (11%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+QL+L G L LP + AL L++L++ L LP E+ LR L L + N+LE LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIE---------------------- 121
L L LT L L N L LP QL+ L L ++
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296
Query: 122 -GNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR 180
N L PR L +L L +L + N L ALP E+ L L L NR PP L
Sbjct: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAH 356
Query: 181 MGRLHILDLDRNRLGGFP 198
LH+LD+ NRL P
Sbjct: 357 TTELHVLDVAGNRLQSLP 374
Score = 87.4 bits (215), Expect = 1e-17
Identities = 71/205 (34%), Positives = 101/205 (49%), Gaps = 2/205 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
LEL L+ LP+++ L +L++L + G L LP+ + L LR L LD N+L LP
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
L L RL L + NRL LPA+ L L L + N LRR P + +L L L++
Sbjct: 216 LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQ 275
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGF-PDLHPLR 204
NRL + + L L L N P +L ++ +L L++DRN L P++
Sbjct: 276 NRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCV 335
Query: 205 ALRVFSY-DHNPVTGPPRVADTVFL 228
AL V S D+ PP +A T L
Sbjct: 336 ALSVLSLRDNRLAVLPPELAHTTEL 360
Score = 86.7 bits (213), Expect = 2e-17
Identities = 57/156 (36%), Positives = 81/156 (51%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S RL LP+ + L L L +S LR LP+ I +L++L IL +D N+L + +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L+ L L N L+ALP +L L L ++ N L P + VAL L + D
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRD 344
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRM 181
NRL LP EL T L L + GNR + P AL +
Sbjct: 345 NRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380
Score = 80.9 bits (198), Expect = 1e-15
Identities = 76/217 (35%), Positives = 97/217 (44%), Gaps = 3/217 (1%)
Query: 14 DAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILA 73
D QLRS L L+ L+ LP V L+ L L + L+ LP + L +L L
Sbjct: 122 DGFTQLRSL-AHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 74 LDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLL 133
L N LE LPD L LP L L+L N+L ALP + L+ L CL + N L P L
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 134 RLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
LV L L + N LR LP + ++ L L + NR E A+ L L L N
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 194 LGGFP-DLHPLRALRVFSYDHNPVTG-PPRVADTVFL 228
L P L L L + D N + PP + V L
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL 337
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 105 bits (263), Expect = 4e-23
Identities = 67/175 (38%), Positives = 87/175 (49%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L LS ++RLP V +L +L VS + E+PE I+ + L I N L RLP
Sbjct: 62 RKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
DG +L L L L L ALP D L +L L + N L+ P L LV L+ L +
Sbjct: 122 DGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
G N L LP L + LR LWL N+ PP L + RL LD+ NRL P
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Score = 93.2 bits (230), Expect = 2e-19
Identities = 63/168 (37%), Positives = 84/168 (50%)
Query: 27 ELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGL 86
+ SG L RLP L L L ++ L+ LP ++ L L L L N L+ LP L
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Query: 87 CRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDN 146
L +L +L LGGN L LP L +LR LW++ N L P L L L L + +N
Sbjct: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
Query: 147 RLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
RL LPAEL + L L L N P + ++ +L IL +D+NRL
Sbjct: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 90.9 bits (224), Expect = 1e-18
Identities = 68/198 (34%), Positives = 87/198 (43%), Gaps = 23/198 (11%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+QL+L G L LP + AL L++L++ L LP E+ LR L L + N+LE LP
Sbjct: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIE---------------------- 121
L L LT L L N L LP QL+ L L ++
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296
Query: 122 -GNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR 180
N L PR L +L L +L + N L ALP E+ L L L NR PP L
Sbjct: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAH 356
Query: 181 MGRLHILDLDRNRLGGFP 198
LH+LD+ NRL P
Sbjct: 357 TTELHVLDVAGNRLQSLP 374
Score = 87.4 bits (215), Expect = 1e-17
Identities = 71/205 (34%), Positives = 101/205 (49%), Gaps = 2/205 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
LEL L+ LP+++ L +L++L + G L LP+ + L LR L LD N+L LP
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
L L RL L + NRL LPA+ L L L + N LRR P + +L L L++
Sbjct: 216 LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQ 275
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGF-PDLHPLR 204
NRL + + L L L N P +L ++ +L L++DRN L P++
Sbjct: 276 NRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCV 335
Query: 205 ALRVFSY-DHNPVTGPPRVADTVFL 228
AL V S D+ PP +A T L
Sbjct: 336 ALSVLSLRDNRLAVLPPELAHTTEL 360
Score = 86.7 bits (213), Expect = 2e-17
Identities = 57/156 (36%), Positives = 81/156 (51%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S RL LP+ + L L L +S LR LP+ I +L++L IL +D N+L + +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L+ L L N L+ALP +L L L ++ N L P + VAL L + D
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRD 344
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRM 181
NRL LP EL T L L + GNR + P AL +
Sbjct: 345 NRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380
Score = 80.9 bits (198), Expect = 1e-15
Identities = 76/217 (35%), Positives = 97/217 (44%), Gaps = 3/217 (1%)
Query: 14 DAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILA 73
D QLRS L L+ L+ LP V L+ L L + L+ LP + L +L L
Sbjct: 122 DGFTQLRSL-AHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 74 LDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLL 133
L N LE LPD L LP L L+L N+L ALP + L+ L CL + N L P L
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 134 RLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
LV L L + N LR LP + ++ L L + NR E A+ L L L N
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 194 LGGFP-DLHPLRALRVFSYDHNPVTG-PPRVADTVFL 228
L P L L L + D N + PP + V L
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL 337
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 105 bits (263), Expect = 4e-23
Identities = 66/176 (37%), Positives = 89/176 (50%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q + SG L RLP + L L L V+ L+ LPE I L L L L N L LP
Sbjct: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
D L +L RL L LG N + LP L L+ LW++GN L P+ + L L L +
Sbjct: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
+NRL LP E+ +T L L + N E P + ++ +L IL +D+NRL P+
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPE 283
Score = 92.8 bits (229), Expect = 3e-19
Identities = 56/176 (31%), Positives = 87/176 (49%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L LS ++RLP + +L +L VS + E+PE I + L++ N L RLP
Sbjct: 62 RKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ L LT L + L +LP + L +L L + N L P L +L L+ L +
Sbjct: 122 ESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
G+N + LP + + L+ LWL GN+ E P + + L LD+ NRL P+
Sbjct: 182 GNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
Score = 88.2 bits (217), Expect = 8e-18
Identities = 60/175 (34%), Positives = 85/175 (48%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+ L L G +L LP + L L L VS L LPEEI L L L + N LE +P
Sbjct: 200 KDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
DG+ +L +L+ L + NRL LP + +SL L + N L P+ + +L L +L
Sbjct: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNA 319
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
N+L +LP E+ L + NR P + + LH+LD+ NRL P
Sbjct: 320 DRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Score = 85.5 bits (210), Expect = 5e-17
Identities = 58/168 (34%), Positives = 89/168 (52%), Gaps = 1/168 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S RL RLP + L+ L L +S L +P+ I +L++L IL +D N+L +LP+
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ LT L L N+LL LP +L+ L L + N L P+ + +L + D
Sbjct: 285 VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRD 344
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
NRL +PAE+ + T L L + GNR P +L + +L L L N+
Sbjct: 345 NRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391
Score = 84.7 bits (208), Expect = 9e-17
Identities = 65/196 (33%), Positives = 94/196 (47%), Gaps = 1/196 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
LEL L LP ++ L RL++L + + LPE I L L+ L LD N+L LP
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L L L + NRL LP + + L SL L I N L P + +L L L++
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLR 204
NRL LP + L L L N+ P ++ ++ +L L+ DRN+L P ++
Sbjct: 276 NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC 335
Query: 205 ALRVFSYDHNPVTGPP 220
+L VF N +T P
Sbjct: 336 SLTVFCVRDNRLTRIP 351
Score = 60.1 bits (144), Expect = 2e-09
Identities = 60/211 (28%), Positives = 89/211 (42%), Gaps = 30/211 (14%)
Query: 59 LPEEIEEL-RELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALP---ADFAQL-- 112
+PEEI R L L LD N+L LP+ +L +L +L L N + LP A+F QL
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
Query: 113 ------------------QSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAE 154
++L+ GN L R P L L L + D L++LP
Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
Query: 155 LPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDH 213
+ + L L L N P +L ++ RL LDL N + P+ + L L+ D
Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206
Query: 214 NPVTGPPRVADTV-----FLVGEGAVERMAE 239
N ++ P+ + V E +ER+ E
Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
Score = 50.1 bits (118), Expect = 2e-06
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 1/99 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
+L L+ +L LP ++ L +L L L LP+EI L + + N+L R+P
Sbjct: 293 ELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPA 352
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
+ + L L + GNRLL LP L+ L+ LW+ N
Sbjct: 353 EVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDN 390
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 104 bits (259), Expect = 1e-22
Identities = 57/170 (33%), Positives = 93/170 (54%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
+L L L LP+++ L L++L VS G++E PE I+ + L I+ N + +LPD
Sbjct: 73 KLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPD 132
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
G +L LT+LYL L LPA+F +L L+ L + N L+ P+ + RL L+ L +G
Sbjct: 133 GFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
N +P L +++GL+ W+ NR P + + +L LD+ +N +
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
Score = 81.3 bits (199), Expect = 9e-16
Identities = 55/175 (31%), Positives = 82/175 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L L ++ LP + L KL + L LP I L LR L + N ++ P
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ + LT + N + LP F+QL +L L++ FL P RL LQ L++
Sbjct: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILEL 168
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+N+L+ LP + R+T L L L N F E P L ++ L +D NRL P
Sbjct: 169 RENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
Score = 78.2 bits (191), Expect = 8e-15
Identities = 64/243 (26%), Positives = 100/243 (41%), Gaps = 29/243 (11%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
+E S + +LP L L +LY++ L LP L +L+IL L N+L+ LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ RL +L RL LG N +P QL L+ W++ N L P + L L L +
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD------ 199
N + + + L+ L L N ++ P + + + L +D N+L PD
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 200 ------------------LHPLRALRVFSYDHNPVTG-PPRVAD----TVFLVGEGAVER 236
+ L LR F+ DHN + PP + TV + +E
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLET 359
Query: 237 MAE 239
+ E
Sbjct: 360 LPE 362
Score = 75.9 bits (185), Expect = 4e-14
Identities = 49/198 (24%), Positives = 93/198 (46%), Gaps = 1/198 (0%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L+L +P + LS L++ ++ L +P I L++L L + N +E +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+G+ L L L N L LP L+++ L I+ N L P + L++++ L
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDC 306
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHP 202
N + ALP+ + ++T LR N ++ PP + + +L L N+L P ++
Sbjct: 307 SFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
Query: 203 LRALRVFSYDHNPVTGPP 220
++ L+V + N + P
Sbjct: 367 MQKLKVINLSDNRLKNLP 384
Score = 75.9 bits (185), Expect = 4e-14
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 1/182 (0%)
Query: 17 EQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDF 76
EQL SG ++ + RL +P + +L +L L VS + + E I L+ L L
Sbjct: 204 EQL-SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 77 NKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLV 136
N L++LP+ + L +T L + N+L+ LP L S+ L N + P + +L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
Query: 137 ALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGG 196
L++ N L+ LP E+ + L+L+ N+ E P + M +L +++L NRL
Sbjct: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
Query: 197 FP 198
P
Sbjct: 383 LP 384
Score = 74.3 bits (181), Expect = 1e-13
Identities = 47/168 (27%), Positives = 82/168 (48%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S + + + LQ L +S L++LPE I L+ + L +D N+L LPD
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L + L N + ALP+ QL +LR + N+L++ P + + L +
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
N+L LP E+ M L+ + L NR + P + ++ +L + L N+
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 72.0 bits (175), Expect = 6e-13
Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 2/197 (1%)
Query: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
L+ S L ++P + + L++LY+ + ELP+++ + L L+L N L LP
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+ L L L + N + P + + L + N + + P +L+ L L +
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
D L LPA R+T L+ L L N+ + P + R+ +L LDL N P+ L L
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
Query: 204 RALRVFSYDHNPVTGPP 220
L+ F D N +T P
Sbjct: 207 SGLKEFWMDANRLTFIP 223
Score = 70.9 bits (172), Expect = 1e-12
Identities = 42/153 (27%), Positives = 71/153 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q L LS L++LP + +L + L + L LP+ I L + L FN++E LP
Sbjct: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ +L L N L LP + +++ L++ N L P + + L+ + +
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL 375
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPP 176
DNRL+ LP ++ L +WL N+ + P
Sbjct: 376 SDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 104 bits (259), Expect = 1e-22
Identities = 57/170 (33%), Positives = 93/170 (54%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
+L L L LP+++ L L++L VS G++E PE I+ + L I+ N + +LPD
Sbjct: 73 KLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPD 132
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
G +L LT+LYL L LPA+F +L L+ L + N L+ P+ + RL L+ L +G
Sbjct: 133 GFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
N +P L +++GL+ W+ NR P + + +L LD+ +N +
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
Score = 81.3 bits (199), Expect = 9e-16
Identities = 55/175 (31%), Positives = 82/175 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L L ++ LP + L KL + L LP I L LR L + N ++ P
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ + LT + N + LP F+QL +L L++ FL P RL LQ L++
Sbjct: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILEL 168
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+N+L+ LP + R+T L L L N F E P L ++ L +D NRL P
Sbjct: 169 RENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
Score = 78.2 bits (191), Expect = 8e-15
Identities = 64/243 (26%), Positives = 100/243 (41%), Gaps = 29/243 (11%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
+E S + +LP L L +LY++ L LP L +L+IL L N+L+ LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ RL +L RL LG N +P QL L+ W++ N L P + L L L +
Sbjct: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD------ 199
N + + + L+ L L N ++ P + + + L +D N+L PD
Sbjct: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 200 ------------------LHPLRALRVFSYDHNPVTG-PPRVAD----TVFLVGEGAVER 236
+ L LR F+ DHN + PP + TV + +E
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLET 359
Query: 237 MAE 239
+ E
Sbjct: 360 LPE 362
Score = 75.9 bits (185), Expect = 4e-14
Identities = 49/198 (24%), Positives = 93/198 (46%), Gaps = 1/198 (0%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L+L +P + LS L++ ++ L +P I L++L L + N +E +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+G+ L L L N L LP L+++ L I+ N L P + L++++ L
Sbjct: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDC 306
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHP 202
N + ALP+ + ++T LR N ++ PP + + +L L N+L P ++
Sbjct: 307 SFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
Query: 203 LRALRVFSYDHNPVTGPP 220
++ L+V + N + P
Sbjct: 367 MQKLKVINLSDNRLKNLP 384
Score = 75.9 bits (185), Expect = 4e-14
Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 1/182 (0%)
Query: 17 EQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDF 76
EQL SG ++ + RL +P + +L +L L VS + + E I L+ L L
Sbjct: 204 EQL-SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 77 NKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLV 136
N L++LP+ + L +T L + N+L+ LP L S+ L N + P + +L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
Query: 137 ALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGG 196
L++ N L+ LP E+ + L+L+ N+ E P + M +L +++L NRL
Sbjct: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
Query: 197 FP 198
P
Sbjct: 383 LP 384
Score = 74.3 bits (181), Expect = 1e-13
Identities = 47/168 (27%), Positives = 82/168 (48%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++S + + + LQ L +S L++LPE I L+ + L +D N+L LPD
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L + L N + ALP+ QL +LR + N+L++ P + + L +
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHS 354
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
N+L LP E+ M L+ + L NR + P + ++ +L + L N+
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 72.0 bits (175), Expect = 6e-13
Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 2/197 (1%)
Query: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
L+ S L ++P + + L++LY+ + ELP+++ + L L+L N L LP
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+ L L L + N + P + + L + N + + P +L+ L L +
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPL 203
D L LPA R+T L+ L L N+ + P + R+ +L LDL N P+ L L
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
Query: 204 RALRVFSYDHNPVTGPP 220
L+ F D N +T P
Sbjct: 207 SGLKEFWMDANRLTFIP 223
Score = 70.9 bits (172), Expect = 1e-12
Identities = 42/153 (27%), Positives = 71/153 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q L LS L++LP + +L + L + L LP+ I L + L FN++E LP
Sbjct: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ +L L N L LP + +++ L++ N L P + + L+ + +
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL 375
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPP 176
DNRL+ LP ++ L +WL N+ + P
Sbjct: 376 SDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 100 bits (248), Expect = 2e-21
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 9/228 (3%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
++ LSG RL ++P +C + L LY+ TGL L L LR L L N L P
Sbjct: 261 EIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPL 320
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+C L L L L N++ LP++ L L+ L + GN FP +L L +L+ L +G
Sbjct: 321 QICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIG 380
Query: 145 DN---RLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-L 200
+ +L +P + ++ L+ L++ N E P +L M L +LD N L PD +
Sbjct: 381 QDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAI 440
Query: 201 HPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERMAERDEPTPRPP 248
+AL+ + N +T P D++ ++ + D P PP
Sbjct: 441 CQAQALKELRLEDNLLTHLPENLDSLV-----NLKVLTLMDNPMEEPP 483
Score = 91.3 bits (225), Expect = 9e-19
Identities = 57/173 (32%), Positives = 92/173 (53%)
Query: 21 SGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLE 80
+G Q+ ++ L LP+++C S+L L +S L +P+ ELR++ + L N+LE
Sbjct: 211 TGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLE 270
Query: 81 RLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQS 140
++P +CR L LYLG L L F L +LR L + N L P + L L+
Sbjct: 271 KVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEV 330
Query: 141 LQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
L + DN++ LP+EL ++ L+ L L GN F FP +L + L L + +++
Sbjct: 331 LGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQ 383
Score = 84.7 bits (208), Expect = 9e-17
Identities = 54/176 (30%), Positives = 91/176 (51%), Gaps = 2/176 (1%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
++ S + L +P + + L+++++ + E+P+EI+ L+ +R+L LD N L L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQ-LQSLRCLWIEGNFLRRFPRPLLR-LVALQSLQM 143
L L L L L N + + L +LR L + L+ P + + L L+ L +
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
N L+ LP E+ T LR ++L N+FE FP L + L I+DLD N++G P+
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
Score = 83.2 bits (204), Expect = 2e-16
Identities = 54/192 (28%), Positives = 86/192 (44%), Gaps = 1/192 (0%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L L+G L+ LP + ++L+++Y+ P+E+ L L I+ LD NK+ +P+
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L L + Y+ N L LPA Q L L + N L P+ L + + +
Sbjct: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLR 204
NRL +P + R T L L+L + + L LDL +N L P + L+
Sbjct: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326
Query: 205 ALRVFSYDHNPV 216
L V D N +
Sbjct: 327 NLEVLGLDDNKI 338
Score = 81.6 bits (200), Expect = 7e-16
Identities = 57/205 (27%), Positives = 95/205 (46%), Gaps = 3/205 (1%)
Query: 11 LPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELR 70
LP + Q + +++ L + P +C L L+ + + + +PEEI L L+
Sbjct: 157 LPKEIVNQTKL--REIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
Query: 71 ILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPR 130
+ N L LP LC+ +L+ L L N L ++P FA+L+ + + + GN L + PR
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
Query: 131 PLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLD 190
+ R +L L +G+ L L + LR L L N P + + L +L LD
Sbjct: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
Query: 191 RNRLGGFP-DLHPLRALRVFSYDHN 214
N++G P +L L L++ N
Sbjct: 335 DNKIGQLPSELGSLSKLKILGLTGN 359
Score = 77.4 bits (189), Expect = 1e-14
Identities = 60/197 (30%), Positives = 90/197 (45%), Gaps = 29/197 (14%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+LS L P +CAL L+ L + + +LP E+ L +L+IL L N+ P+
Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEE 367
Query: 86 LCRLPRLTRLYLG---GNRLLALPADFAQLQSLRCLWIEGN------------------- 123
+ L L +LY+G G +L +P +LQSL+ L+IE N
Sbjct: 368 VLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLD 427
Query: 124 ----FLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL 179
L++ P + + AL+ L++ DN L LP L + L+ L L N EE P +
Sbjct: 428 CRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVC 487
Query: 180 RMGRLHI---LDLDRNR 193
G I L +RNR
Sbjct: 488 AEGNEAIWKYLKENRNR 504
Score = 72.0 bits (175), Expect = 6e-13
Identities = 54/182 (29%), Positives = 85/182 (46%), Gaps = 7/182 (3%)
Query: 24 QQLELSGRRLRRLPSAVCA-LSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERL 82
++L L L+ +P + L L+ L ++G L+ LP+EI +LR + L N+ E
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P LC L L + L N++ A+P + L L+ ++ N L P L + L L
Sbjct: 181 PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHP 202
+ N L ++P + + + L GNR E+ P + R LH+L L G LH
Sbjct: 241 LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYL------GNTGLHR 294
Query: 203 LR 204
LR
Sbjct: 295 LR 296
Score = 71.6 bits (174), Expect = 8e-13
Identities = 55/170 (32%), Positives = 83/170 (48%), Gaps = 6/170 (3%)
Query: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVS---GTGLR 57
+G+ ++ +LPS+ + + L L+G P V +L+ L+KLY+ G L
Sbjct: 331 LGLDDNKIGQLPSELGSLSKL--KILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLT 388
Query: 58 ELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRC 117
+PE I +L+ L+ L ++ N LE LP L +P L L N L LP Q Q+L+
Sbjct: 389 YVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE 448
Query: 118 LWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLY 167
L +E N L P L LV L+ L + DN + P E+ G +W Y
Sbjct: 449 LRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV-CAEGNEAIWKY 497
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 98.2 bits (243), Expect = 8e-21
Identities = 55/199 (27%), Positives = 100/199 (50%), Gaps = 4/199 (2%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+L +++++P+++ + L L + P E+ L L++L L N+L+++
Sbjct: 538 LDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSD 597
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCL---WIEGNFLRRFPRPLLRLVALQSLQ 142
+C L + +L N+ + P + QLQSL L I+G L R P L + L+ L
Sbjct: 598 ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELD 657
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LH 201
+ +N +R +P + + L L Y N+ PP+LL + L L+L N L P ++
Sbjct: 658 ISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIY 717
Query: 202 PLRALRVFSYDHNPVTGPP 220
+ +L+ ++D NP+ PP
Sbjct: 718 NIFSLKEINFDDNPLLRPP 736
Score = 90.5 bits (223), Expect = 2e-18
Identities = 57/192 (29%), Positives = 94/192 (48%), Gaps = 1/192 (0%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+QL + PS + L L+ L + LR +P+ + L+ LR+L L++N+L P
Sbjct: 237 RQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFP 296
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
LC LP+L L L GN + +LP + +L++L L ++ N L + +L+ ++ LQ+
Sbjct: 297 KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQL 356
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHP 202
DN+L + ++ LR L L N + P + L L L N+L P +H
Sbjct: 357 ADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHK 416
Query: 203 LRALRVFSYDHN 214
L LR + N
Sbjct: 417 LNNLRKLHVNRN 428
Score = 87.4 bits (215), Expect = 1e-17
Identities = 61/213 (28%), Positives = 100/213 (46%), Gaps = 24/213 (11%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYV-----------------------SGTGLRELPEE 62
L LS +L LP + L+ L+KL+V SG + ++P E
Sbjct: 400 LSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIE 459
Query: 63 IEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEG 122
I+ +++ + L +NK+ P GLC L L L + GN + +P D + + L L +
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSE 519
Query: 123 NFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMG 182
N L F L+ L+ L +G N+++ +PA + M L L L N+FE FP L +
Sbjct: 520 NKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLE 579
Query: 183 RLHILDLDRNRLGGF-PDLHPLRALRVFSYDHN 214
L +LDL N+L D+ L+ ++ ++ N
Sbjct: 580 NLQVLDLSENQLQKISSDICNLKGIQKLNFSSN 612
Score = 86.3 bits (212), Expect = 3e-17
Identities = 63/219 (28%), Positives = 107/219 (48%), Gaps = 5/219 (2%)
Query: 3 IAESTPDELPSDAEEQLRSGDQQ--LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP 60
+ E +P ++ + ++QL G + L + L+ P + + ++ LY+ ++
Sbjct: 122 VGEVSP-QVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQ 180
Query: 61 -EEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLW 119
+ +L L IL+L N L LP + L L L + N + +P + +QL ++R L+
Sbjct: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240
Query: 120 IEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL 179
N++ FP L L L+ L +G N+LR +P LP + LR L L N+ FP AL
Sbjct: 241 FYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC 300
Query: 180 RMGRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHNPVT 217
+ +L LDL N + P ++ L+ L DHN +T
Sbjct: 301 FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLT 339
Score = 84.7 bits (208), Expect = 9e-17
Identities = 60/203 (29%), Positives = 100/203 (49%), Gaps = 8/203 (3%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
++ELS ++ P +CAL L L V+G + E+P +I ++L L L NKL +
Sbjct: 468 KIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
C L L L LG N++ +PA + + SL L + N FPR L L LQ L +
Sbjct: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDR------NRLGGFP 198
+N+L+ + +++ + G++ L N+F FP L ++ L L++ + RL G
Sbjct: 588 ENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPG-- 645
Query: 199 DLHPLRALRVFSYDHNPVTGPPR 221
+L + L+ +N + PR
Sbjct: 646 ELSNMTQLKELDISNNAIREIPR 668
Score = 83.2 bits (204), Expect = 2e-16
Identities = 63/222 (28%), Positives = 100/222 (45%), Gaps = 3/222 (1%)
Query: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP 60
+ + E+ LPS E QL + L +S + +P + L +++L+ + P
Sbjct: 193 LSLQENGLSSLPS--EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP 250
Query: 61 EEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWI 120
++E L L IL+L NKL +PD L L L L L N+L P L L L +
Sbjct: 251 SDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDL 310
Query: 121 EGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR 180
GN + P+ + L L++L M N+L L E+ ++ ++ L L N+ E +
Sbjct: 311 TGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
Query: 181 MGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVTGPPR 221
L IL LD+N L P+ + L S N +T P+
Sbjct: 371 FRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPK 412
Score = 80.5 bits (197), Expect = 2e-15
Identities = 53/191 (27%), Positives = 88/191 (46%), Gaps = 6/191 (3%)
Query: 8 PDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELR 67
PD LPS ++ L L +L P A+C L +L L ++G + LP+EI EL+
Sbjct: 273 PDTLPSLKTLRV------LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
Query: 68 ELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRR 127
L L +D NKL L + +L ++ L L N+L + + LR L ++ N L+
Sbjct: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386
Query: 128 FPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHIL 187
P + L+ L + DN+L LP + ++ LR L + N + + + + L
Sbjct: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSL 446
Query: 188 DLDRNRLGGFP 198
+ N + P
Sbjct: 447 EFSGNIITDVP 457
Score = 76.3 bits (186), Expect = 3e-14
Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 1/200 (0%)
Query: 22 GDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER 81
G + L L L LPS + L L+ L VS + +P+EI +L +R L N +E
Sbjct: 189 GLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 82 LPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSL 141
P L L L L LG N+L +P L++LR L +E N L FP+ L L L SL
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 142 QMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DL 200
+ N + +LP E+ + L L + N+ + ++ ++ L L N+L +
Sbjct: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
Query: 201 HPLRALRVFSYDHNPVTGPP 220
R LR+ D N + P
Sbjct: 369 ENFRELRILILDKNLLKNIP 388
Score = 67.8 bits (164), Expect = 1e-11
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 3/142 (2%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEE---IEELRELRILALDFNKLE 80
Q L+LS +L+++ S +C L +QKL S P E ++ L +L I + KL
Sbjct: 582 QVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLT 641
Query: 81 RLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQS 140
RLP L + +L L + N + +P + +L++L L N + P LL L LQ
Sbjct: 642 RLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQ 701
Query: 141 LQMGDNRLRALPAELPRMTGLR 162
L + N L ALP+ + + L+
Sbjct: 702 LNLSGNNLTALPSAIYNIFSLK 723
Score = 64.3 bits (155), Expect = 1e-10
Identities = 46/175 (26%), Positives = 82/175 (46%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+ L + +L L + L ++++L ++ L + +IE RELRIL LD N L+ +P
Sbjct: 329 ETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIP 388
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ + L L L N+L LP +L +LR L + N + + + L + SL+
Sbjct: 389 EKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEF 448
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
N + +P E+ + + L N+ FP L + L+ L ++ N + P
Sbjct: 449 SGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
Score = 63.9 bits (154), Expect = 2e-10
Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 3/155 (1%)
Query: 22 GDQQLELSGRRLRRLPSAVCALSRLQKLYVS---GTGLRELPEEIEELRELRILALDFNK 78
G Q+L S + P +C L L++L +S G L LP E+ + +L+ L + N
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
Query: 79 LERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVAL 138
+ +P + L L L+ N++ LP L L+ L + GN L P + + +L
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSL 722
Query: 139 QSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEE 173
+ + DN L P E+ + L + Y R +E
Sbjct: 723 KEINFDDNPLLRPPVEICKGKQLYTIARYLQRADE 757
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 94.4 bits (233), Expect = 1e-19
Identities = 67/211 (31%), Positives = 101/211 (47%), Gaps = 3/211 (1%)
Query: 11 LPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELR 70
LPS +E + +L L +L+ LP+ V L L L +S L LP+ ++ L++LR
Sbjct: 115 LPSSIKELTQL--TELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLR 172
Query: 71 ILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPR 130
+L L NKL +P + RL LT LYL NR+ + D L L L I N +++ P
Sbjct: 173 MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232
Query: 131 PLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLD 190
+ L L +L + N+L LP E+ T + L L N + P + + L L L
Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292
Query: 191 RNRLGGFP-DLHPLRALRVFSYDHNPVTGPP 220
NRL P L AL + ++N ++ P
Sbjct: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Score = 92.4 bits (228), Expect = 4e-19
Identities = 65/218 (29%), Positives = 108/218 (49%), Gaps = 1/218 (0%)
Query: 5 ESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIE 64
+S+ E+ + + +L+LS R + LPS++ L++L +LY+ L+ LP E+
Sbjct: 84 KSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVG 143
Query: 65 ELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNF 124
L L LAL N L LPD L L +L L L N+L +P+ +L SL L++ N
Sbjct: 144 CLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR 203
Query: 125 LRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRL 184
+ + + L L L + +N+++ LPAE+ + L L + N+ E P + ++
Sbjct: 204 ITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQI 263
Query: 185 HILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVTGPPR 221
LDL N L PD + L +L +N ++ PR
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR 301
Score = 76.3 bits (186), Expect = 3e-14
Identities = 53/175 (30%), Positives = 85/175 (48%), Gaps = 1/175 (0%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
+L + +L LP + + +L ++ L ++PE++ L L +L L N L++LP
Sbjct: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
GL L +L L L N+L +LP + A L+ L+ L + N L PR + L L L +G
Sbjct: 443 GLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLG 502
Query: 145 DNRLRALPAELPRMTGLRGLWLYGN-RFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+N L LP E+ + L L+L N P L +L I+ ++ L P
Sbjct: 503 ENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Score = 75.9 bits (185), Expect = 4e-14
Identities = 57/201 (28%), Positives = 92/201 (45%), Gaps = 7/201 (3%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L LS L LP ++ L +L+ L + LRE+P + L L L L FN++ +
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKD 210
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L +L+ L + N++ LPA+ +L +L L + N L P+ + + +L +
Sbjct: 211 IKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQH 270
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD--LHPL 203
N L LP + ++ L L L NR P +L + L L+L+ N + P+ L L
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 204 RALRVFSYDHN-----PVTGP 219
L + N PV GP
Sbjct: 331 VKLNSLTLARNCFQLYPVGGP 351
Score = 75.9 bits (185), Expect = 4e-14
Identities = 64/218 (29%), Positives = 105/218 (48%), Gaps = 9/218 (4%)
Query: 6 STPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEE 65
S PD L D ++LR L+L +LR +PS V L L LY+ + + ++I+
Sbjct: 160 SLPDSL--DNLKKLR----MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213
Query: 66 LRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFL 125
L +L +L++ NK+++LP + L L L + N+L LP + + L ++ N L
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Query: 126 RRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL-RMGRL 184
P + L +L L + NRL A+P L + + L L L N P +LL + +L
Sbjct: 274 LDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKL 333
Query: 185 HILDLDRNRLGGFPDLHPLRALRVFS--YDHNPVTGPP 220
+ L L RN +P P + ++S +HN + P
Sbjct: 334 NSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIP 371
Score = 64.7 bits (156), Expect = 9e-11
Identities = 57/206 (27%), Positives = 92/206 (44%), Gaps = 14/206 (6%)
Query: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
L + R+ ++P + + ++ L KL + L LP + + L L N+L ++P+
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+ L L L L N L LP L+ LR L +E N L P + L LQ L +
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLT 479
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHPL- 203
+N+L LP + +T L L L N P + + L L L+ N P+LH L
Sbjct: 480 NNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN-----PNLHSLP 534
Query: 204 ------RALRVFSYDHNPVTG-PPRV 222
L + S ++ P++ PP++
Sbjct: 535 FELALCSKLSIMSIENCPLSHLPPQI 560
Score = 52.4 bits (124), Expect = 5e-07
Identities = 37/107 (34%), Positives = 50/107 (46%), Gaps = 1/107 (0%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
++L+L +L LP+ + L LQKL ++ L LP I L L L L N L LP
Sbjct: 451 RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLP 510
Query: 84 DGLCRLPRLTRLYLGGN-RLLALPADFAQLQSLRCLWIEGNFLRRFP 129
+ + L L LYL N L +LP + A L + IE L P
Sbjct: 511 EEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 92.4 bits (228), Expect = 4e-19
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 10/206 (4%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q+L LS +LR LP V L+R+ L + G L+ LP E+ L+ L++L ++ N L +P
Sbjct: 74 QKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVP 133
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
L +L L L N L LPA FA L LR L + NF P + L L L +
Sbjct: 134 AELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHV 193
Query: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHP 202
G NRL + + + L+ GN FP +L + L +L+L+ N + P +LH
Sbjct: 194 GSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHL 253
Query: 203 L-RALRV--------FSYDHNPVTGP 219
L R +R+ HNP++ P
Sbjct: 254 LCRLVRIAWNPMDKGLHISHNPLSKP 279
Score = 75.1 bits (183), Expect = 7e-14
Identities = 53/168 (31%), Positives = 84/168 (50%), Gaps = 1/168 (0%)
Query: 55 GLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQS 114
G+ ++P+ + L E++ L L N+L LP + +L R+ L L GNRL +LP + + LQ
Sbjct: 59 GMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
Query: 115 LRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEF 174
L+ L++ N L P L L+ L + N L LPA ++ LR L L N F
Sbjct: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHI 178
Query: 175 PPALLRMGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVTGPPR 221
P + + L L + NRL + + L +L++F + N + PR
Sbjct: 179 PMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPR 226
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 92.4 bits (228), Expect = 4e-19
Identities = 67/217 (30%), Positives = 96/217 (44%), Gaps = 10/217 (4%)
Query: 10 ELPSDAEEQLRSGDQQ----------LELSGRRLRRLPSAVCALSRLQKLYVSGTGLREL 59
++P +A + L G + L +S +L+ L + L L L + L L
Sbjct: 61 DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSL 120
Query: 60 PEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLW 119
P I EL L+ L + NKL+ LP+ + L L LYL N L + F QL +L L
Sbjct: 121 PSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLD 180
Query: 120 IEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL 179
+ N L P L +L L + N L++LPAE+ RM L+ L N E PP L
Sbjct: 181 LSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA 240
Query: 180 RMGRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPV 216
M L +L L RN+L P+ L+ N +
Sbjct: 241 GMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQI 277
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/177 (26%), Positives = 80/177 (45%), Gaps = 22/177 (12%)
Query: 18 QLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFN 77
+L+ ++LS +L + +C L +L L + L LPEE+E L L+ + L FN
Sbjct: 446 ELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFN 505
Query: 78 KLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVA 137
+ + LP+ L R+ L + + N++ ++ P+ + +
Sbjct: 506 RFKMLPEVLYRIFTLETILISNNQVGSVD----------------------PQKMKMMEN 543
Query: 138 LQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL 194
L +L + +N L +P EL LR L L GN F A+L G IL+ R+R+
Sbjct: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI 600
Score = 55.1 bits (131), Expect = 7e-08
Identities = 56/213 (26%), Positives = 93/213 (43%), Gaps = 20/213 (9%)
Query: 22 GDQQLELSGRRLRRLPSA----VCALSRLQKLYVSGTGLRELPEEI-EELRELRILALDF 76
G Q E + LPS + A+ L+ L S +P+E+ + ++ + +++F
Sbjct: 373 GPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINF 432
Query: 77 NKLERLPDGLCRLPR--------LTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRF 128
+K + LC +P+ ++ + L N+L + + LQ L L + NFL
Sbjct: 433 SKNQ-----LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSL 487
Query: 129 PRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR-MGRLHIL 187
P + LV LQ++ + NR + LP L R+ L + + N+ P ++ M L L
Sbjct: 488 PEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTL 547
Query: 188 DLDRNRLGGF-PDLHPLRALRVFSYDHNPVTGP 219
DL N L P+L LR D NP P
Sbjct: 548 DLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVP 580
Score = 48.1 bits (113), Expect = 9e-06
Identities = 44/156 (28%), Positives = 68/156 (43%), Gaps = 26/156 (16%)
Query: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP 60
+ ++ + LP++ R + L+ + L +P + + L+ LY+ LR LP
Sbjct: 202 LNLSSNELKSLPAEINRMKRL--KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Query: 61 E--------------------EIEELRELR-ILALDF--NKLERLPDGLCRLPRLTRLYL 97
E E E L+ L IL LD NKL+ +PD + L L RL L
Sbjct: 260 EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319
Query: 98 GGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLL 133
N + +LP L L+ L +EGN LR R ++
Sbjct: 320 SNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREII 354
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 92.4 bits (228), Expect = 4e-19
Identities = 64/195 (32%), Positives = 99/195 (50%), Gaps = 13/195 (6%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGT---GLRELPEEIEE---LRELRILALDFN 77
Q L++SG L L + AL L+ L G LP+ + + R L++L L N
Sbjct: 71 QLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGN 130
Query: 78 KLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVA 137
+ +P L L L L LGGN+L ++PA+ LQSL CL++ GNF++ P L L +
Sbjct: 131 CFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPS 190
Query: 138 LQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGF 197
L L + DN+++++P +L ++ LR L L+ N P +L + L L L N L
Sbjct: 191 LNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL--- 247
Query: 198 PDLHPLRALRVFSYD 212
+R +R +YD
Sbjct: 248 ----VVRFVRDLTYD 258
Score = 82.8 bits (203), Expect = 3e-16
Identities = 51/142 (35%), Positives = 74/142 (52%), Gaps = 1/142 (0%)
Query: 8 PDELPSD-AEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEEL 66
P LP A+ L Q L LSG + +P+++ L LQ L + G L+ +P EIE L
Sbjct: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
Query: 67 RELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLR 126
+ L L L N ++ +P L LP L L L N++ ++P +QL SLR L + N L
Sbjct: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLT 225
Query: 127 RFPRPLLRLVALQSLQMGDNRL 148
PR +L L+ L+ L + N L
Sbjct: 226 YLPREILNLIHLEELSLRGNPL 247
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 88.2 bits (217), Expect = 8e-18
Identities = 57/156 (36%), Positives = 80/156 (51%), Gaps = 2/156 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
QL LS +L +P + L L+ L + ELP +I L++L+ L L N+L LP
Sbjct: 44 QLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR 103
Query: 85 GLCRLPRLTRLYLGGNRLL--ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
G LP L L L N L +LP +F L +LR L++ N P + +L LQ L
Sbjct: 104 GFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILS 163
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
+ DN L +LP E+ +T L+ L + GNR PP L
Sbjct: 164 LRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
Score = 77.8 bits (190), Expect = 1e-14
Identities = 61/212 (28%), Positives = 97/212 (45%), Gaps = 8/212 (3%)
Query: 16 EEQLRSGDQQLELSGRRLRRL--PSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILA 73
EE ++++S R + + + + LS + +L +S L +P I EL+ L +L
Sbjct: 10 EESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLN 69
Query: 74 LDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFL--RRFPRP 131
N++E LP + L +L L LG NRL LP F L +L L + N L P
Sbjct: 70 FFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGN 129
Query: 132 LLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDR 191
L L++L + DN LP ++ ++T L+ L L N P + + +L L +
Sbjct: 130 FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQG 189
Query: 192 NRLGGFP----DLHPLRALRVFSYDHNPVTGP 219
NRL P +L +VF ++NP P
Sbjct: 190 NRLTVLPPELGNLDLTGQKQVFKAENNPWVTP 221
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 86.7 bits (213), Expect = 2e-17
Identities = 69/203 (33%), Positives = 96/203 (47%), Gaps = 7/203 (3%)
Query: 3 IAESTPDELP---SDAEEQLRSGDQQLELSGRRLR----RLPSAVCALSRLQKLYVSGTG 55
+ E+T +LP S + G Q+ + G LR LP+ + L+ L L +S
Sbjct: 77 LLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNS 136
Query: 56 LRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSL 115
L LP + ++R L L L N L LP+ L LP LT L + NRL LP L +L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
Query: 116 RCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFP 175
+ L + N L P + L +L L + NRL++LPA L + LR L L+ N P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 176 PALLRMGRLHILDLDRNRLGGFP 198
L R+ L LDL N+L P
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 79.0 bits (193), Expect = 5e-15
Identities = 57/154 (37%), Positives = 77/154 (50%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+LS L LP+ V + L L +S L ELPE + L L L + N+L+ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
L L L RL L N L LP + L SL L + N L+ P L L +L+ L +
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL 179
N L ++PA+L R+ L L L N+ + PP LL
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPELL 283
Score = 58.5 bits (140), Expect = 7e-09
Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q+L+LS L LP + L L +L ++ L+ LP + LR LR+L L N L +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
L RLP LTRL L N+L LP + +R ++GN
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGN 293
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 86.7 bits (213), Expect = 2e-17
Identities = 69/203 (33%), Positives = 96/203 (47%), Gaps = 7/203 (3%)
Query: 3 IAESTPDELP---SDAEEQLRSGDQQLELSGRRLR----RLPSAVCALSRLQKLYVSGTG 55
+ E+T +LP S + G Q+ + G LR LP+ + L+ L L +S
Sbjct: 77 LLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNS 136
Query: 56 LRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSL 115
L LP + ++R L L L N L LP+ L LP LT L + NRL LP L +L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
Query: 116 RCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFP 175
+ L + N L P + L +L L + NRL++LPA L + LR L L+ N P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 176 PALLRMGRLHILDLDRNRLGGFP 198
L R+ L LDL N+L P
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 79.0 bits (193), Expect = 5e-15
Identities = 57/154 (37%), Positives = 77/154 (50%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+LS L LP+ V + L L +S L ELPE + L L L + N+L+ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
L L L RL L N L LP + L SL L + N L+ P L L +L+ L +
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALL 179
N L ++PA+L R+ L L L N+ + PP LL
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPELL 283
Score = 58.5 bits (140), Expect = 7e-09
Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q+L+LS L LP + L L +L ++ L+ LP + LR LR+L L N L +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
L RLP LTRL L N+L LP + +R ++GN
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGN 293
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/216 (28%), Positives = 96/216 (44%), Gaps = 25/216 (11%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L++ + LPS++ L++LQ+ + TGL ++PE I + L +L L N + +P G
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIE------------GNFLR------- 126
+ L RL L L N++ +P + + SL L + N L+
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 127 -----RFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRM 181
P +L + AL+ L MG N+L LP + RM L LWL N P + M
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
Query: 182 GRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHNPV 216
L L L N+L P + + LR ++ NP+
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 68.9 bits (167), Expect = 5e-12
Identities = 39/140 (27%), Positives = 75/140 (53%), Gaps = 1/140 (0%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVS-GTGLRELPEEIEELRELRILALDFNKLERL 82
Q+L LS +++ +P + + L+KL ++ + +LP+E+ L +L L L N +
Sbjct: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P + +P L L +G N+L LP ++Q+L LW++ N + P+ + + L +L
Sbjct: 192 PLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLV 251
Query: 143 MGDNRLRALPAELPRMTGLR 162
+ +N+L+ +P + M LR
Sbjct: 252 LSNNKLQDIPVCMEEMANLR 271
Score = 52.8 bits (125), Expect = 4e-07
Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
Query: 24 QQLELS-GRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERL 82
++LEL+ R + LP + L +L L +S +P + + L L + NKLE+L
Sbjct: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
PD + R+ L L+L N + LP + +++L L + N L+ P + + L+ +
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVN 274
Query: 143 MGDNRLRALPAELPRMTG 160
DN L+ L LP G
Sbjct: 275 FRDNPLK-LKVSLPPSEG 291
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 82.4 bits (202), Expect = 4e-16
Identities = 63/196 (32%), Positives = 94/196 (47%), Gaps = 1/196 (0%)
Query: 22 GDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER 81
G + L L + ++ +C L++L L + L E+PEE++ L L+ L L N++ R
Sbjct: 38 GLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICR 97
Query: 82 LPDGLCR-LPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQS 140
G C L L L L N L LP + ++L+SL + I N L PR L L L
Sbjct: 98 FAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVE 157
Query: 141 LQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDL 200
LQ+ N+L +P E+ + L+ L L N P L + +L ILD+ N + FP
Sbjct: 158 LQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSG 217
Query: 201 HPLRALRVFSYDHNPV 216
LR F + NP+
Sbjct: 218 FQDLKLREFYCEGNPL 233
Score = 67.8 bits (164), Expect = 1e-11
Identities = 46/170 (27%), Positives = 83/170 (48%), Gaps = 4/170 (2%)
Query: 1 MGIAESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVC-ALSRLQKLYVSGTGLREL 59
+ + + +E+P E + + + L LSG R+ R C L L L ++ L +L
Sbjct: 65 LNLGNNLLEEVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQL 122
Query: 60 PEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLW 119
P+E+ L+ L +++++N+L +P LC L L L L N+L+ +P + L+ L+ L
Sbjct: 123 PQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLL 182
Query: 120 IEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGN 169
+ N + P L L L+ L + N ++ P+ + LR + GN
Sbjct: 183 LARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGN 231
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 1/167 (0%)
Query: 34 RRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLT 93
R L A+ + + ++G + ++P + +L L+ L L N + ++ LC L +LT
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
Query: 94 RLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRF-PRPLLRLVALQSLQMGDNRLRALP 152
L LG N L +P + L SL+ L + GN + RF P L L L + +N L LP
Sbjct: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
Query: 153 AELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
E+ R+ L + + N+ P L + L L L+ N+L P+
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPE 170
Score = 61.2 bits (147), Expect = 1e-09
Identities = 38/127 (29%), Positives = 66/127 (51%), Gaps = 2/127 (1%)
Query: 97 LGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELP 156
L G ++ +P+ +L L+ L ++ N + + L L L +L +G+N L +P E+
Sbjct: 21 LNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMK 80
Query: 157 RMTGLRGLWLYGNRFEEFPP-ALLRMGRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHN 214
+T L+ L L GNR F P A + L +L+L+ N L P ++ L++L S ++N
Sbjct: 81 YLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYN 140
Query: 215 PVTGPPR 221
+ PR
Sbjct: 141 QLASIPR 147
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 82.0 bits (201), Expect = 6e-16
Identities = 57/176 (32%), Positives = 86/176 (48%), Gaps = 2/176 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEI--EELRELRILALDFNKLERL 82
+LEL L R+P A+ +LS LQ+L + +R + E I + L+ L L L NK+ +
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P + + L LY N+L +LP LQ LRCL + N + P + L LQ L
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+ N++ LP +L + LR L L N P + ++ +L L+L N L P
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Score = 64.3 bits (155), Expect = 1e-10
Identities = 46/134 (34%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+ L S +L LP AV +L +L+ L VS + +P EI L+ L+ L + NK++ LP
Sbjct: 709 ESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILP 768
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPL--LRLVALQSL 141
L + +L L LG N + +LP QL L L ++GN L R P L R++ L
Sbjct: 769 KQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL 828
Query: 142 QMGDNRLRALPAEL 155
+ D+ LP E+
Sbjct: 829 VVEDHLFDTLPLEV 842
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 82.0 bits (201), Expect = 6e-16
Identities = 57/176 (32%), Positives = 86/176 (48%), Gaps = 2/176 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEI--EELRELRILALDFNKLERL 82
+LEL L R+P A+ +LS LQ+L + +R + E I + L+ L L L NK+ +
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P + + L LY N+L +LP LQ LRCL + N + P + L LQ L
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+ N++ LP +L + LR L L N P + ++ +L L+L N L P
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Score = 64.3 bits (155), Expect = 1e-10
Identities = 46/134 (34%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+ L S +L LP AV +L +L+ L VS + +P EI L+ L+ L + NK++ LP
Sbjct: 709 ESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILP 768
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPL--LRLVALQSL 141
L + +L L LG N + +LP QL L L ++GN L R P L R++ L
Sbjct: 769 KQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL 828
Query: 142 QMGDNRLRALPAEL 155
+ D+ LP E+
Sbjct: 829 VVEDHLFDTLPLEV 842
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 82.0 bits (201), Expect = 6e-16
Identities = 66/188 (35%), Positives = 90/188 (47%), Gaps = 3/188 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
Q +LS R +P A C L L+ L + LR L + L L L L N+L LP
Sbjct: 72 QADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPP 131
Query: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMG 144
+C+LP L L + N+L ALP D L SLR L + N L+ P L L +L+ L +
Sbjct: 132 YICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVR 190
Query: 145 DNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDLHPLR 204
N+L LP EL + +R L NR P + R+ L ++ LD N L P L+
Sbjct: 191 RNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLK 249
Query: 205 A-LRVFSY 211
L +F Y
Sbjct: 250 GKLHIFKY 257
Score = 55.5 bits (132), Expect = 6e-08
Identities = 35/86 (40%), Positives = 49/86 (56%), Gaps = 5/86 (5%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDF--NKLER 81
+QL++S L+ LPS +C LS L+ L V L LP EEL +L ++ LDF N++ R
Sbjct: 162 RQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLP---EELGDLPLVRLDFSCNRVSR 218
Query: 82 LPDGLCRLPRLTRLYLGGNRLLALPA 107
+P CRL L + L N L + PA
Sbjct: 219 IPVSFCRLRHLQVILLDSNPLQSPPA 244
Score = 40.0 bits (92), Expect = 0.002
Identities = 31/99 (31%), Positives = 41/99 (41%), Gaps = 3/99 (3%)
Query: 125 LRRFPRPLLRLVALQSLQMGD---NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRM 181
L+ FPR R L + D NR +P ++ L GL LY N PAL +
Sbjct: 54 LKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNL 113
Query: 182 GRLHILDLDRNRLGGFPDLHPLRALRVFSYDHNPVTGPP 220
L L+L RN+L P LRV +N + P
Sbjct: 114 TALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALP 152
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 81.6 bits (200), Expect = 7e-16
Identities = 52/145 (35%), Positives = 74/145 (51%), Gaps = 2/145 (1%)
Query: 36 LPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRL 95
+P + L L+ L + ELP +I L++L+ L L N+L LP G LP L L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 96 YLGGNRLL--ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPA 153
L N L +LP +F L +LR L++ N P + +L LQ L + DN L +LP
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 154 ELPRMTGLRGLWLYGNRFEEFPPAL 178
E+ +T L+ L + GNR PP L
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
Score = 64.3 bits (155), Expect = 1e-10
Identities = 55/188 (29%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
Query: 59 LPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCL 118
+P I EL+ L +L N++E LP + L +L L LG NRL LP F L +L L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 119 WIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
+ N L +LP +T LR L+L N FE PP +
Sbjct: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
Query: 179 LRMGRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERM 237
++ +L IL L N L P ++ L L+ N +T P + L G+ V +
Sbjct: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 160
Query: 238 AERDEPTP 245
TP
Sbjct: 161 ENNPWVTP 168
Score = 63.2 bits (152), Expect = 3e-10
Identities = 42/132 (31%), Positives = 59/132 (44%), Gaps = 2/132 (1%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER--LP 83
L ++ LP+ + +L +L+ L + L LP L L +L L +N L LP
Sbjct: 15 LNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLP 74
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
L L LYL N LP D +L L+ L + N L P+ + L L+ L +
Sbjct: 75 GNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHI 134
Query: 144 GDNRLRALPAEL 155
NRL LP EL
Sbjct: 135 QGNRLTVLPPEL 146
Score = 49.3 bits (116), Expect = 4e-06
Identities = 29/77 (37%), Positives = 42/77 (54%)
Query: 36 LPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRL 95
LP L+ L+ LY+S LP +I +L +L+IL+L N L LP + L +L L
Sbjct: 73 LPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKEL 132
Query: 96 YLGGNRLLALPADFAQL 112
++ GNRL LP + L
Sbjct: 133 HIQGNRLTVLPPELGNL 149
Score = 35.4 bits (80), Expect = 0.060
Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 6/76 (7%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L LS LP + L++LQ L + L LP+EI EL +L+ L + N+L LP
Sbjct: 86 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP-- 143
Query: 86 LCRLPRLTRLYLGGNR 101
P L L L G +
Sbjct: 144 ----PELGNLDLTGQK 155
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 80.1 bits (196), Expect = 2e-15
Identities = 60/178 (33%), Positives = 87/178 (48%), Gaps = 2/178 (1%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPE--EIEELRELRILALDFNKLER 81
++LEL L R+P AV +L LQ+L + LR + E + R+L L L N++
Sbjct: 585 RELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAY 644
Query: 82 LPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSL 141
+P+ + +L L +LYL N+L LP+ LR L + N L P + L LQ L
Sbjct: 645 VPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHL 704
Query: 142 QMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
+ N L ALP EL LR L L N+ + P + + L L+L NRL P+
Sbjct: 705 ALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPE 762
Score = 65.5 bits (158), Expect = 5e-11
Identities = 53/154 (34%), Positives = 71/154 (46%), Gaps = 25/154 (16%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
+QL LS +L LPS + S L+ L VS GL LP E+ L+ L+ LAL +N LE LP
Sbjct: 656 EQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALP 715
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
+ L +L L LG N+L L L+ AL L++
Sbjct: 716 EELFFCRKLRTLLLGDNQLSQLSPHVGALR-----------------------ALSRLEL 752
Query: 144 GDNRLRALPAELPRMTGLR--GLWLYGNRFEEFP 175
NRL ALP EL GL+ GL + ++ P
Sbjct: 753 KGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786
Score = 62.4 bits (150), Expect = 5e-10
Identities = 66/248 (26%), Positives = 110/248 (44%), Gaps = 36/248 (14%)
Query: 7 TPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELP-----E 61
+P LP + LR + + + LR +P V L L++L++ G +EL E
Sbjct: 470 SPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLE 529
Query: 62 EIEELRELRILALDFNKLE---RLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCL 118
+ EL++L++L+L N + + D L RL+ L+ G RL+AL + +L +LR L
Sbjct: 530 SLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLS-LHNDGARLVALNS-LKKLAALREL 587
Query: 119 WIEGNFLRRFPRPLLRLVALQSLQMGDNRLRAL-------------------------PA 153
+ L R P + L ALQ L + DN LR++ P
Sbjct: 588 ELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPE 647
Query: 154 ELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGF-PDLHPLRALRVFSYD 212
+ ++ L L+L N+ E P L L +LD+ N L P++ L+ L+ +
Sbjct: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
Query: 213 HNPVTGPP 220
+N + P
Sbjct: 708 YNALEALP 715
Score = 57.8 bits (138), Expect = 1e-08
Identities = 40/98 (40%), Positives = 52/98 (53%)
Query: 19 LRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNK 78
L SG + L++S L LP V L LQ L +S L LPEE+ R+LR L L N+
Sbjct: 674 LCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQ 733
Query: 79 LERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLR 116
L +L + L L+RL L GNRL ALP + L+
Sbjct: 734 LSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
Score = 34.3 bits (77), Expect = 0.13
Identities = 58/231 (25%), Positives = 89/231 (38%), Gaps = 43/231 (18%)
Query: 5 ESTPDELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIE 64
E TP++L + R+ +LEL+ L LP V LS ++ L + P +
Sbjct: 401 EWTPEKLRQKLQ---RNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLS 457
Query: 65 ELRELRILALDFNKLERLPDGLCRLPR--LTRLYLGGNRLLALPADFAQLQSLRCLWIEG 122
+L L+ L+L + RLP L R L + + L +P L+ L L +EG
Sbjct: 458 QLVHLQELSL-LHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEG 516
Query: 123 NFLRRFPRPLLRLVALQSL----QMGDNRLRALPAELP---------------------- 156
FP+ L R L+SL Q+ LR+ ++P
Sbjct: 517 ----LFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARL 572
Query: 157 -------RMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDL 200
++ LR L L E P A+ +G L LDL N L ++
Sbjct: 573 VALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEI 623
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 78.2 bits (191), Expect = 8e-15
Identities = 61/151 (40%), Positives = 74/151 (49%), Gaps = 3/151 (1%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L LS L LP A+ AL L L V+ L+ LP + L L+ L L N L+ LP
Sbjct: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
+ L L L L NRL +LPA A L+SLR L + N L P L RL L L + D
Sbjct: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
Query: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPP 176
N+LR LP EL +R L GN E P
Sbjct: 127 NQLRDLPPELLDAPFVR---LQGNPLGEASP 154
Score = 71.2 bits (173), Expect = 1e-12
Identities = 50/133 (37%), Positives = 65/133 (48%)
Query: 66 LRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFL 125
+R L L L N L LP+ L LP LT L + NRL LP L +L+ L + N L
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 126 RRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLH 185
P + L +L L + NRL++LPA L + LR L L+ N P L R+ L
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 186 ILDLDRNRLGGFP 198
LDL N+L P
Sbjct: 121 RLDLRDNQLRDLP 133
Score = 68.9 bits (167), Expect = 5e-12
Identities = 50/134 (37%), Positives = 67/134 (50%)
Query: 46 LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLAL 105
L L +S L ELPE + L L L + N+L+ LP L L L RL L N L L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 106 PADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLW 165
P + L SL L + N L+ P L L +L+ L + N L ++PA+L R+ L L
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 166 LYGNRFEEFPPALL 179
L N+ + PP LL
Sbjct: 124 LRDNQLRDLPPELL 137
Score = 58.5 bits (140), Expect = 7e-09
Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q+L+LS L LP + L L +L ++ L+ LP + LR LR+L L N L +P
Sbjct: 51 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 110
Query: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
L RLP LTRL L N+L LP + +R ++GN
Sbjct: 111 ADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGN 147
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 74.3 bits (181), Expect = 1e-13
Identities = 60/212 (28%), Positives = 91/212 (42%), Gaps = 26/212 (12%)
Query: 10 ELPSDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELREL 69
E P A + + +LS RL +P C L+ L + +R +PE I L+ L
Sbjct: 71 EFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQAL 130
Query: 70 RILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFP 129
L + N+L LP LC LP L L N+L++LP + L+ L L + N ++ P
Sbjct: 131 TFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIP 189
Query: 130 RPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDL 189
+ L AL+ L + N L LP EL + +R LD
Sbjct: 190 SQIGNLEALRDLNVRRNHLVHLPEELAELPLIR------------------------LDF 225
Query: 190 DRNRLGGFPDLH-PLRALRVFSYDHNPVTGPP 220
N++ P + LR L+ + D+NP+ PP
Sbjct: 226 SCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/171 (29%), Positives = 71/171 (41%), Gaps = 4/171 (2%)
Query: 53 GTGLRELPEEIEELRELRILALDFNKLERLPDGLCR--LPRLTRLYLGGNRLLALPADFA 110
G+ R L +EE +L+L KL P G L TR L NRL +P +
Sbjct: 43 GSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEAC 102
Query: 111 QLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNR 170
SL L + N +R P +L L AL L + N+L LP L + L+ L N+
Sbjct: 103 HFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNK 161
Query: 171 FEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHNPVTGPP 220
P + + L LD+ N + P + L ALR + N + P
Sbjct: 162 LVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLP 212
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 73.6 bits (179), Expect = 2e-13
Identities = 63/212 (29%), Positives = 104/212 (49%), Gaps = 8/212 (3%)
Query: 17 EQLRSGDQQLELSGRRLRRLPS-AVCALSRLQKLYVSGTGLREL-PEEIEELRELRILAL 74
E L + Q L++S + +LP A L++L ++G L + P+ + L+EL++L L
Sbjct: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
Query: 75 DFNKLERLPDGLCR-LPRLTRLYLGGNRLLALPAD-FAQLQSLRCLWIEGNFLRRFP-RP 131
N+L+ +P R L L L L N + ++P D F L LR LW++ N L P P
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 132 LLRLVALQSLQMGDNRLRALP-AELPRMTGLRGLWLYGNRFEEFPPALL-RMGRLHILDL 189
L L LQ+L + N++ ++P ++ L L L+ N+ + L LDL
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 190 DRNRLGGFPD-LHPLRALRVFSYDHNPVTGPP 220
+ N LG FP + L +L+ + N ++ P
Sbjct: 233 NYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264
Score = 42.0 bits (97), Expect = 6e-04
Identities = 56/192 (29%), Positives = 85/192 (44%), Gaps = 14/192 (7%)
Query: 26 LELSGRRLRRLPSAVC--ALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
L L ++R L S C L L+ L ++ L E P+ I+ L L+ L N + +P
Sbjct: 206 LHLHNNKIRSL-SQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIP 264
Query: 84 DG-LCRLPRLTRLYLGGNRLLAL-PADFAQLQSLRCLWIEG-NFLRRFPRPLLRLVALQS 140
DG P L ++L N L + + F L L L I G + +++FP L V L+S
Sbjct: 265 DGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN-LTGTVHLES 323
Query: 141 LQMGDNRLRALPAEL-PRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRL----- 194
L + ++ ++P L LR L L N + P+ L + L RN++
Sbjct: 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL-PSFNGCHALEEISLQRNQIYQIKE 382
Query: 195 GGFPDLHPLRAL 206
G F L LR L
Sbjct: 383 GTFQGLISLRIL 394
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 73.6 bits (179), Expect = 2e-13
Identities = 54/176 (30%), Positives = 84/176 (47%), Gaps = 2/176 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEI--EELRELRILALDFNKLERL 82
+LEL L R+P ++ +L LQ++ + L+ + E I + L L L L +N + +
Sbjct: 595 ELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI 654
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P + L L RLYL N++ +P + LR L + N L P + L LQ+L
Sbjct: 655 PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+ NR+ LP EL + LR L L N + P + + L ++L NRL P
Sbjct: 715 ITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 2/157 (1%)
Query: 24 QQLELSGRRLRRLPSAVCA--LSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER 81
Q+++L L+ + + L RL L + + +P +I L L L L+ NK+E+
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 82 LPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSL 141
+P L +L L L N L LPAD LQ+L+ L I N + P L + L++L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
Query: 142 QMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
+G+N L++LP+ + +T L + L GNR E P L
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+LS L LP+ + L LQ L ++ + LP E+ + R+LR L L N L+ LP
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSR 749
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLR 116
+ L LT++ L GNRL LP + + L+
Sbjct: 750 VGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 39.3 bits (90), Expect = 0.004
Identities = 23/71 (32%), Positives = 35/71 (49%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q L ++ R+ LP + +L+ L++ L+ LP + EL L + L N+LE LP
Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Query: 84 DGLCRLPRLTR 94
L P L R
Sbjct: 771 VELGECPLLKR 781
Score = 28.1 bits (61), Expect = 9.5
Identities = 17/54 (31%), Positives = 27/54 (50%)
Query: 125 LRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
L P + LV L+ L++ +P + ++TGL+ LWLY + PAL
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPAL 488
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 73.6 bits (179), Expect = 2e-13
Identities = 54/176 (30%), Positives = 84/176 (47%), Gaps = 2/176 (1%)
Query: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEI--EELRELRILALDFNKLERL 82
+LEL L R+P ++ +L LQ++ + L+ + E I + L L L L +N + +
Sbjct: 595 ELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI 654
Query: 83 PDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQ 142
P + L L RLYL N++ +P + LR L + N L P + L LQ+L
Sbjct: 655 PIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714
Query: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
+ NR+ LP EL + LR L L N + P + + L ++L NRL P
Sbjct: 715 ITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 2/157 (1%)
Query: 24 QQLELSGRRLRRLPSAVCA--LSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER 81
Q+++L L+ + + L RL L + + +P +I L L L L+ NK+E+
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 82 LPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSL 141
+P L +L L L N L LPAD LQ+L+ L I N + P L + L++L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736
Query: 142 QMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
+G+N L++LP+ + +T L + L GNR E P L
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
L+LS L LP+ + L LQ L ++ + LP E+ + R+LR L L N L+ LP
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSR 749
Query: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLR 116
+ L LT++ L GNRL LP + + L+
Sbjct: 750 VGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 39.3 bits (90), Expect = 0.004
Identities = 23/71 (32%), Positives = 35/71 (49%)
Query: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Q L ++ R+ LP + +L+ L++ L+ LP + EL L + L N+LE LP
Sbjct: 711 QNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Query: 84 DGLCRLPRLTR 94
L P L R
Sbjct: 771 VELGECPLLKR 781
Score = 28.1 bits (61), Expect = 9.5
Identities = 17/54 (31%), Positives = 27/54 (50%)
Query: 125 LRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
L P + LV L+ L++ +P + ++TGL+ LWLY + PAL
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPAL 488
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.143 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,639,244
Number of Sequences: 37866
Number of extensions: 745291
Number of successful extensions: 4661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 121
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 3377
Number of HSP's gapped (non-prelim): 811
length of query: 292
length of database: 18,247,518
effective HSP length: 101
effective length of query: 191
effective length of database: 14,423,052
effective search space: 2754802932
effective search space used: 2754802932
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.