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Search of human proteins with 222537752
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222537752 Src homology 2 domain containing transforming
protein D [Homo sapiens]
(340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222537752 Src homology 2 domain containing transforming prote... 718 0.0
gi|106879210 Src homology 2 domain containing adaptor protein B ... 249 2e-66
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 245 5e-65
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 202 3e-52
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 68 1e-11
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 68 1e-11
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 68 1e-11
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 68 1e-11
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 68 1e-11
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 62 7e-10
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 62 7e-10
gi|194239668 SHC (Src homology 2 domain containing) transforming... 56 5e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming... 56 5e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming... 55 7e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 55 7e-08
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens] 55 1e-07
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens] 55 1e-07
gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens] 55 1e-07
gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens] 55 1e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 53 4e-07
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 52 6e-07
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 52 1e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 49 5e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 49 6e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 49 6e-06
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 49 8e-06
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 49 8e-06
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 49 8e-06
gi|4503787 fyn-related kinase [Homo sapiens] 49 8e-06
gi|169790811 SHC (Src homology 2 domain containing) transforming... 49 8e-06
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 718 bits (1853), Expect = 0.0
Identities = 340/340 (100%), Positives = 340/340 (100%)
Query: 1 MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP 60
MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP
Sbjct: 1 MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP 60
Query: 61 GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD 120
GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD
Sbjct: 61 GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD 120
Query: 121 DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE 180
DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE
Sbjct: 121 DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE 180
Query: 181 YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW 240
YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW
Sbjct: 181 YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW 240
Query: 241 FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG 300
FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG
Sbjct: 241 FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG 300
Query: 301 QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP
Sbjct: 301 QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 249 bits (637), Expect = 2e-66
Identities = 183/510 (35%), Positives = 233/510 (45%), Gaps = 173/510 (33%)
Query: 1 MAKWLRDYLSFGGRRP--PPQPPTPDYTE------------------------------- 27
MAKWL Y S G + PPQPP PDY E
Sbjct: 1 MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA 60
Query: 28 -----------------SDILRAYRAQKNLDFEDPYEDAESRLEPDPA-----GPGDSKN 65
SD++RAYRAQK DFEDPY S L A G S
Sbjct: 61 SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE 120
Query: 66 PG------------------------------DAKYGSP--------------------- 74
PG + GSP
Sbjct: 121 PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS 180
Query: 75 -KHRLIKVEAADMARAKALLG---------------------------------GPGEEL 100
KHRLIKVE+A A LG G +++
Sbjct: 181 PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV 240
Query: 101 EADTEYLDPFDAQ-----PHPAPPDDGYMEPYDAQWVMSEL--------PGRGVQLYDTP 147
+Y DPFDA+ GYMEPY+AQ +M+E +G+QLYDTP
Sbjct: 241 TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP 300
Query: 148 YEEQDPETADGPPSGQKP--RQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEW 205
YE + S P R+S++PQ+D+RPADEYDQPWEW + I A A QF+ E
Sbjct: 301 YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIP-ALAAQFNGNEK 359
Query: 206 ERTPGSAKELRRPPPRSP----QP------------AERVDPALPLEKQPWFHGPLNRAD 249
++ S RR R+P +P ERVDPA+PLEKQ W+HG ++R D
Sbjct: 360 RQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGD 419
Query: 250 AESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSV 309
AE+LL LCKE SYLVR S+T+ D SLSLRS+QGF+H+K A+T+E + VLGQ+S PF SV
Sbjct: 420 AENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSV 478
Query: 310 PELVLHYSSRPLPVQGAEHLALLYPVVTQT 339
PE++ +Y++R LP++GAEHL+LLYPV +T
Sbjct: 479 PEVIHYYTTRKLPIKGAEHLSLLYPVAVRT 508
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 245 bits (625), Expect = 5e-65
Identities = 149/367 (40%), Positives = 199/367 (54%), Gaps = 93/367 (25%)
Query: 55 PDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQ- 113
P P G + + + R+I++ R A+L +Y DPFD Q
Sbjct: 67 PQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAIL----------EDYADPFDVQE 116
Query: 114 -----------PHPAPPDDGYMEPYDAQWVMSELPG------RGVQLYDTPYE-EQDPET 155
P P +DGYMEPY+AQ +M+E+ G + + LYDTPYE E+D T
Sbjct: 117 TGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT 176
Query: 156 ADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAV----------------- 198
+G PR+SR+P++DERP +EYDQPWEWKK+ IS+AFAV
Sbjct: 177 PEGE-GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235
Query: 199 ------------------------------QFDSPEWE-RTPGSAKELRRPP------PR 221
QF+ PE +PG ++ R PP P+
Sbjct: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
Query: 222 SPQP---------AERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQ 272
S +P E DPALPLE Q W+HG ++R DAE+LL LCKE SYLVR SET+
Sbjct: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN 355
Query: 273 DCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALL 332
D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP++GAEH++LL
Sbjct: 356 DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
Query: 333 YPVVTQT 339
YPV +T
Sbjct: 416 YPVAIRT 422
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 202 bits (514), Expect = 3e-52
Identities = 116/293 (39%), Positives = 158/293 (53%), Gaps = 67/293 (22%)
Query: 105 EYLDPFDAQPHPAPPD-------DGYMEPYDAQWVMSELPGRGV---------------- 141
+Y DP+DA+ D DGYMEPYDAQ +++E+ RG
Sbjct: 203 DYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCE 262
Query: 142 -------------------------QLYDTPYEEQDPETADGPPSGQ---KPRQSRMPQE 173
QLYDTPYE A+G P + +P SR+P+
Sbjct: 263 PADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEP-----AEGGPRAEGKARPPDSRLPEN 317
Query: 174 DERPADEYDQPWEWKKDHISRAFAVQFDSPE-----------WERTPGSAKELRRPPPRS 222
DERPA EY+QPWEWKK+ I RA +VQF+ E R +++ +P
Sbjct: 318 DERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSD 377
Query: 223 PQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQ 282
E+VDP LPLEKQPW+HG ++RA+AES L CKE YLVR SE+ S++L++SQ
Sbjct: 378 HSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQ 437
Query: 283 GFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
G +H+ A+T++N+ L Q S F S+PE+V +YS+ LP +GAEH+ LLYPV
Sbjct: 438 GCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
G E+R + P+ + P LEK W+HGP++R+ AE LLS GS+LVR SE+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 187
Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
+P S+SLR H + T + +V + S F ++ ELV H+S+
Sbjct: 188 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 235
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
G E+R + P+ + P LEK W+HGP++R+ AE LLS GS+LVR SE+
Sbjct: 143 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 202
Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
+P S+SLR H + T + +V + S F ++ ELV H+S+
Sbjct: 203 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 250
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
G E+R + P+ + P LEK W+HGP++R+ AE LLS GS+LVR SE+
Sbjct: 122 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 181
Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
+P S+SLR H + T + +V + S F ++ ELV H+S+
Sbjct: 182 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 229
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
G E+R + P+ + P LEK W+HGP++R+ AE LLS GS+LVR SE+
Sbjct: 128 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 187
Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
+P S+SLR H + T + +V + S F ++ ELV H+S+
Sbjct: 188 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 235
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 1/109 (0%)
Query: 210 GSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSET 269
G E+R + P+ + P LEK W+HGP++R+ AE LLS GS+LVR SE+
Sbjct: 107 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES 166
Query: 270 NPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
+P S+SLR H + T + +V + S F ++ ELV H+S+
Sbjct: 167 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAES-RFSTLAELVHHHST 214
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 62.0 bits (149), Expect = 7e-10
Identities = 35/94 (37%), Positives = 53/94 (56%), Gaps = 1/94 (1%)
Query: 225 PAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGF 284
P+ + P LEK W+HGP++R AE LLS GS+LVR SE++P S+SLR
Sbjct: 112 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 171
Query: 285 LHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
H + + ++ + S F ++ ELV H+S+
Sbjct: 172 YHYRINTASDGKLYVSSES-RFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 62.0 bits (149), Expect = 7e-10
Identities = 35/94 (37%), Positives = 53/94 (56%), Gaps = 1/94 (1%)
Query: 225 PAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGF 284
P+ + P LEK W+HGP++R AE LLS GS+LVR SE++P S+SLR
Sbjct: 131 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 190
Query: 285 LHLKFARTRENQVVLGQHSGPFPSVPELVLHYSS 318
H + + ++ + S F ++ ELV H+S+
Sbjct: 191 YHYRINTASDGKLYVSSES-RFNTLAELVHHHST 223
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 55.8 bits (133), Expect = 5e-08
Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 15/188 (7%)
Query: 158 GPPSGQKPR-QSRMPQEDERPADE-YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA-K 213
G P G P + +MP P E +D P ++ +A AV P GSA +
Sbjct: 287 GQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR 346
Query: 214 ELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSE 268
+L P R P P + V A L +PWFHG L+R +AE+LL L G +LVR S
Sbjct: 347 DLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVREST 404
Query: 269 TNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-E 327
T P L+ S HL + + V+ F SV L+ ++ LP+ A
Sbjct: 405 TTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461
Query: 328 HLALLYPV 335
L L PV
Sbjct: 462 ELCLQQPV 469
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 55.8 bits (133), Expect = 5e-08
Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 15/188 (7%)
Query: 158 GPPSGQKPR-QSRMPQEDERPADE-YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA-K 213
G P G P + +MP P E +D P ++ +A AV P GSA +
Sbjct: 397 GQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR 456
Query: 214 ELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSE 268
+L P R P P + V A L +PWFHG L+R +AE+LL L G +LVR S
Sbjct: 457 DLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVREST 514
Query: 269 TNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-E 327
T P L+ S HL + + V+ F SV L+ ++ LP+ A
Sbjct: 515 TTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
Query: 328 HLALLYPV 335
L L PV
Sbjct: 572 ELCLQQPV 579
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 55.5 bits (132), Expect = 7e-08
Identities = 60/189 (31%), Positives = 82/189 (43%), Gaps = 16/189 (8%)
Query: 158 GPPSGQKPR-QSRMPQEDERPADE--YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA- 212
G P G P + +MP PA +D P ++ +A AV P GSA
Sbjct: 397 GQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAP 456
Query: 213 KELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLS 267
++L P R P P + V A L +PWFHG L+R +AE+LL L G +LVR S
Sbjct: 457 RDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVRES 514
Query: 268 ETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA- 326
T P L+ S HL + + V+ F SV L+ ++ LP+ A
Sbjct: 515 TTTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 571
Query: 327 EHLALLYPV 335
L L PV
Sbjct: 572 SELCLQQPV 580
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 55.5 bits (132), Expect = 7e-08
Identities = 60/189 (31%), Positives = 82/189 (43%), Gaps = 16/189 (8%)
Query: 158 GPPSGQKPR-QSRMPQEDERPADE--YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA- 212
G P G P + +MP PA +D P ++ +A AV P GSA
Sbjct: 287 GQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAP 346
Query: 213 KELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLS 267
++L P R P P + V A L +PWFHG L+R +AE+LL L G +LVR S
Sbjct: 347 RDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVRES 404
Query: 268 ETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA- 326
T P L+ S HL + + V+ F SV L+ ++ LP+ A
Sbjct: 405 TTTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 461
Query: 327 EHLALLYPV 335
L L PV
Sbjct: 462 SELCLQQPV 470
>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
Length = 361
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)
Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
WFHG + R +AE LL +G YLVR SE + L+ RS H A+ R+ + VV
Sbjct: 67 WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 125
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
LG+ S + +L+LHY++ PL G L P+ QTP
Sbjct: 126 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 163
>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
Length = 371
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)
Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
WFHG + R +AE LL +G YLVR SE + L+ RS H A+ R+ + VV
Sbjct: 77 WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 135
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
LG+ S + +L+LHY++ PL G L P+ QTP
Sbjct: 136 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 173
>gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)
Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
WFHG + R +AE LL +G YLVR SE + L+ RS H A+ R+ + VV
Sbjct: 95 WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 153
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
LG+ S + +L+LHY++ PL G L P+ QTP
Sbjct: 154 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 191
>gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 6/102 (5%)
Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQ-VV 298
WFHG + R +AE LL +G YLVR SE + L+ RS H A+ R+ + VV
Sbjct: 95 WFHGFITRREAERLLEPKPQGCYLVRFSE-SAVTFVLTYRSRTCCRHFLLAQLRDGRHVV 153
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
LG+ S + +L+LHY++ PL G L P+ QTP
Sbjct: 154 LGEDSA-HARLQDLLLHYTAHPLSPYGE---TLTEPLARQTP 191
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 6/103 (5%)
Query: 222 SPQPAERVDPALP--LEKQPWFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSL 278
SP + + P+L PW++G + R AE L+ EG +L+R SE++P D S+SL
Sbjct: 262 SPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSL 321
Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPL 321
++ H K + +E +GQ F ++ ELV HY P+
Sbjct: 322 KAQGKNKHFK-VQLKETVYCIGQRK--FSTMEELVEHYKKAPI 361
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 52.4 bits (124), Expect = 6e-07
Identities = 43/128 (33%), Positives = 62/128 (48%), Gaps = 14/128 (10%)
Query: 225 PAERVDPALP-----LEKQPWFHGPLNRADAESLLSL---CKEGSYLVRLSETNPQDCSL 276
P +DPA L PWFHGP++R A L+ L G +LVR SET + L
Sbjct: 344 PGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVL 403
Query: 277 SLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQ-GAE---HLALL 332
+ HL+ + T Q + QH FPSV +++ H+ P+P++ GA L+
Sbjct: 404 TFNFQGIAKHLRLSLTERGQCRV-QHL-HFPSVVDMLHHFQRSPIPLECGAACDVRLSSY 461
Query: 333 YPVVTQTP 340
VV+Q P
Sbjct: 462 VVVVSQPP 469
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 7/140 (5%)
Query: 206 ERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLL---SLCKEGSY 262
E GS + + + +P L L PWFHG L+R A L+ G +
Sbjct: 426 ESPGGSGSDSNNTGEQGAETDPEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLF 485
Query: 263 LVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLP 322
++R SET P + L+ HL+ + Q + QH F SV +++ H+ + P+P
Sbjct: 486 VIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHV-QHLW-FQSVLDMLRHFHTHPIP 543
Query: 323 VQ--GAEHLALLYPVVTQTP 340
++ G+ + L V Q P
Sbjct: 544 LESGGSADITLRSYVRAQDP 563
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 5e-06
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 240 WFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVL 299
WFH L+R AE+LL + G +++R S+++P D S+S+R H K R + L
Sbjct: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 300 GQHSGPFPSVPELVLHYSSRPLPVQ 324
FPS+ +LV +Y + + Q
Sbjct: 118 WTEK--FPSLNKLVDYYRTNSISRQ 140
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 13/107 (12%)
Query: 234 PLEKQPWFHGPLNRADAESLL-SLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFART 292
P E + WFHG +++ +A +LL ++ + S+LVR S+ P D SL R+++ K T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404
Query: 293 RENQVVLGQHSGPFPSVPELVLHYS----------SRPLPVQGAEHL 329
NQ ++G + S+ +++ HY P+P+Q E +
Sbjct: 405 PNNQFMMGGRY--YNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 449
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 11/119 (9%)
Query: 227 ERVDPALPLEKQP---WFHGPLNRADAESLLSLC-KEGSYLVRLSETNPQDCSLSLRSSQ 282
E + A+PL P W+HG L+R AE L K GSYL+R S+ P LS S
Sbjct: 165 EEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQM 224
Query: 283 GFL-HLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
+ H + + + G+ F S+ +L+ +YS ++G + LLYPV P
Sbjct: 225 NVVNHFRIIAMCGDYYIGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVAPPEP 277
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 13/107 (12%)
Query: 234 PLEKQPWFHGPLNRADAESLL-SLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFART 292
P E + WFHG +++ +A +LL ++ + S+LVR S+ P D SL R+++ K T
Sbjct: 168 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 227
Query: 293 RENQVVLGQHSGPFPSVPELVLHYS----------SRPLPVQGAEHL 329
NQ ++G + S+ +++ HY P+P+Q E +
Sbjct: 228 PNNQFMMGGRY--YNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 272
Score = 43.1 bits (100), Expect = 4e-04
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 8/103 (7%)
Query: 240 WFHGPLNRADAESLLSLC-KEGSYLVRLSETNPQDCSLSLRSSQGFL-HLKFARTRENQV 297
W+HG L+R AE L K GSYL+R S+ P LS S + H + +
Sbjct: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
Query: 298 VLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP 340
+ G+ F S+ +L+ +YS ++G + LLYPV P
Sbjct: 64 IGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVAPPEP 100
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 48.5 bits (114), Expect = 8e-06
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 223 PQPAERVDPALPLEKQ----PWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSL 278
P P R P P E+Q PW+HG ++R AE +L +G +LVR S TNP L+
Sbjct: 359 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR--ADGDFLVRDSVTNPGQYVLTG 416
Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQ 338
+ HL + + V+ F S+ L+ H+ P+ AE L VV++
Sbjct: 417 MHAGQPKHLLLV---DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSR 473
Query: 339 TP 340
P
Sbjct: 474 EP 475
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 48.5 bits (114), Expect = 8e-06
Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 6/97 (6%)
Query: 240 WFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVV 298
W++G + R AE L+ EG +L+R SE++P D S+SL++S H K + +N
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFK-VQLVDNVYC 343
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
+GQ F ++ ELV HY + P+ +EH LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 48.5 bits (114), Expect = 8e-06
Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 6/97 (6%)
Query: 240 WFHGPLNRADAESLLS-LCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVV 298
W++G + R AE L+ EG +L+R SE++P D S+SL++S H K + +N
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFK-VQLVDNVYC 343
Query: 299 LGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
+GQ F ++ ELV HY + P+ +EH LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 48.5 bits (114), Expect = 8e-06
Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 8/114 (7%)
Query: 206 ERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAES--LLSLCKEGSYL 263
+R GS+++L+ P + +R L+ +PWF G + R+DAE L S K GS+L
Sbjct: 87 KRRDGSSQQLQGYIPSNYVAEDR-----SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFL 141
Query: 264 VRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYS 317
+R SE+ + SLS+ H + R E L + F ++ E V HY+
Sbjct: 142 IRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRR-IFSTLNEFVSHYT 194
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 48.5 bits (114), Expect = 8e-06
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 223 PQPAERVDPALPLEKQ----PWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSL 278
P P R P P E+Q PW+HG ++R AE +L +G +LVR S TNP L+
Sbjct: 466 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR--ADGDFLVRDSVTNPGQYVLTG 523
Query: 279 RSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQ 338
+ HL + + V+ F S+ L+ H+ P+ AE L VV++
Sbjct: 524 MHAGQPKHLLLV---DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSR 580
Query: 339 TP 340
P
Sbjct: 581 EP 582
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.134 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,083,282
Number of Sequences: 37866
Number of extensions: 1144084
Number of successful extensions: 5344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 230
Number of HSP's that attempted gapping in prelim test: 4946
Number of HSP's gapped (non-prelim): 559
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.