Search of human proteins with 222418587

Search of human proteins with 222418587

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222418587 hypothetical protein LOC57495 [Homo sapiens]
         (1742 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222418587 hypothetical protein LOC57495 [Homo sapiens]            3513   0.0  
gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]   221   5e-57
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             51   9e-06
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       49   4e-05
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    48   1e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    48   1e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    48   1e-04
gi|18874090 WD repeat domain 48 [Homo sapiens]                         48   1e-04
gi|16554629 WD repeat domain 5 [Homo sapiens]                          47   1e-04
gi|16554627 WD repeat domain 5 [Homo sapiens]                          47   1e-04
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    47   1e-04
gi|157266266 WD repeat domain 86 [Homo sapiens]                        45   6e-04
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...    44   0.001
gi|23199987 WD repeat domain 5B [Homo sapiens]                         43   0.003
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          42   0.004
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          42   0.004
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          42   0.004
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            42   0.004
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     42   0.005
gi|34304360 nephrocystin 3 [Homo sapiens]                              42   0.005
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    42   0.005
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    42   0.005
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    42   0.005
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    42   0.005
gi|32189425 WD repeat domain 69 [Homo sapiens]                         42   0.007
gi|157671927 spermatogenesis associated 5 [Homo sapiens]               42   0.007
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    41   0.009
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    41   0.009
gi|31542634 filamin A interacting protein 1 [Homo sapiens]             40   0.020
gi|30520335 WD repeat domain 49 [Homo sapiens]                         40   0.026

>gi|222418587 hypothetical protein LOC57495 [Homo sapiens]
          Length = 1742

 Score = 3513 bits (9110), Expect = 0.0
 Identities = 1742/1742 (100%), Positives = 1742/1742 (100%)

Query: 1    MWPAGAGTKLPCPRDSALRRAAFSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALR 60
            MWPAGAGTKLPCPRDSALRRAAFSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALR
Sbjct: 1    MWPAGAGTKLPCPRDSALRRAAFSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALR 60

Query: 61   ENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVG 120
            ENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVG
Sbjct: 61   ENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVG 120

Query: 121  LLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKSEM 180
            LLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKSEM
Sbjct: 121  LLGEKYGNIRIPGEVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKSEM 180

Query: 181  LRSNRNAMQPSTNAENEKTWQEISDEIKKIFKAAVKLLHEKGKMKHSQAKRYLFSAIEDE 240
            LRSNRNAMQPSTNAENEKTWQEISDEIKKIFKAAVKLLHEKGKMKHSQAKRYLFSAIEDE
Sbjct: 181  LRSNRNAMQPSTNAENEKTWQEISDEIKKIFKAAVKLLHEKGKMKHSQAKRYLFSAIEDE 240

Query: 241  FDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIK 300
            FDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIK
Sbjct: 241  FDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIK 300

Query: 301  LRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYIEGLGKQFYEDMIDIIQATIQQ 360
            LRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYIEGLGKQFYEDMIDIIQATIQQ
Sbjct: 301  LRDEFIPTIVASSNLRVYTSVTHCDMKLGYSQEIENHYIEGLGKQFYEDMIDIIQATIQQ 360

Query: 361  NFDTETDTLYDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGHINPLIIYGGPCT 420
            NFDTETDTLYDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGHINPLIIYGGPCT
Sbjct: 361  NFDTETDTLYDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGHINPLIIYGGPCT 420

Query: 421  GKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLLSVCEQLAVNYRC 480
            GKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLLSVCEQLAVNYRC
Sbjct: 421  GKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLLSVCEQLAVNYRC 480

Query: 481  LVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSENDDARKLWWLPAHLPRFVR 540
            LVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSENDDARKLWWLPAHLPRFVR
Sbjct: 481  LVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSENDDARKLWWLPAHLPRFVR 540

Query: 541  IVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYV 600
            IVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYV
Sbjct: 541  IVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYV 600

Query: 601  NNALSKCTLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSR 660
            NNALSKCTLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSR
Sbjct: 601  NNALSKCTLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSR 660

Query: 661  ALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPSNPLRVPYLYIARLKEGLSGYLI 720
            ALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPSNPLRVPYLYIARLKEGLSGYLI
Sbjct: 661  ALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPSNPLRVPYLYIARLKEGLSGYLI 720

Query: 721  ERHVKNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDP 780
            ERHVKNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDP
Sbjct: 721  ERHVKNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDP 780

Query: 781  YLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYH 840
            YLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYH
Sbjct: 781  YLNGCLDLENRSLLEEEKHFMEQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYH 840

Query: 841  LTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIK 900
            LTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIK
Sbjct: 841  LTRCGKTDDLLYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIK 900

Query: 901  NKVTAFPGSLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPER 960
            NKVTAFPGSLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPER
Sbjct: 901  NKVTAFPGSLSAELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPER 960

Query: 961  LPLSSSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSD 1020
            LPLSSSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSD
Sbjct: 961  LPLSSSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSD 1020

Query: 1021 EKYLVVATTNNTLLIYDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKD 1080
            EKYLVVATTNNTLLIYDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKD
Sbjct: 1021 EKYLVVATTNNTLLIYDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKD 1080

Query: 1081 VTVIDLLYGWPLYQFHCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEF 1140
            VTVIDLLYGWPLYQFHCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEF
Sbjct: 1081 VTVIDLLYGWPLYQFHCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEF 1140

Query: 1141 SGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSED 1200
            SGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSED
Sbjct: 1141 SGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSED 1200

Query: 1201 QSAVLICKALSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWR 1260
            QSAVLICKALSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWR
Sbjct: 1201 QSAVLICKALSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWR 1260

Query: 1261 RDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            RDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ
Sbjct: 1261 RDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSS 1380
            SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSS
Sbjct: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSS 1380

Query: 1381 QYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLATGHRVCNILTTLQ 1440
            QYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLATGHRVCNILTTLQ
Sbjct: 1381 QYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLATGHRVCNILTTLQ 1440

Query: 1441 NAFITSANTFVVGMTKSKVLAVSLWTGSITKKFCCEDGTTIVNFKLIPDCPDIIVFITSA 1500
            NAFITSANTFVVGMTKSKVLAVSLWTGSITKKFCCEDGTTIVNFKLIPDCPDIIVFITSA
Sbjct: 1441 NAFITSANTFVVGMTKSKVLAVSLWTGSITKKFCCEDGTTIVNFKLIPDCPDIIVFITSA 1500

Query: 1501 ETVNIWSLTDEVICRRVQLPNNFLKNLEDFEISPNGKLGIIARGDENINVLDLYSGKLRV 1560
            ETVNIWSLTDEVICRRVQLPNNFLKNLEDFEISPNGKLGIIARGDENINVLDLYSGKLRV
Sbjct: 1501 ETVNIWSLTDEVICRRVQLPNNFLKNLEDFEISPNGKLGIIARGDENINVLDLYSGKLRV 1560

Query: 1561 VHASGIIWRQRLSRDGRYLVYICFRNGEEEDENGAIFSLIVMRLADGKNIGACSLYKTPT 1620
            VHASGIIWRQRLSRDGRYLVYICFRNGEEEDENGAIFSLIVMRLADGKNIGACSLYKTPT
Sbjct: 1561 VHASGIIWRQRLSRDGRYLVYICFRNGEEEDENGAIFSLIVMRLADGKNIGACSLYKTPT 1620

Query: 1621 FLALSQRHLNIIVGFDDGSIGIYTVVDRVDAALKIKIATSNSRQIFNNATHTSRPKCNSY 1680
            FLALSQRHLNIIVGFDDGSIGIYTVVDRVDAALKIKIATSNSRQIFNNATHTSRPKCNSY
Sbjct: 1621 FLALSQRHLNIIVGFDDGSIGIYTVVDRVDAALKIKIATSNSRQIFNNATHTSRPKCNSY 1680

Query: 1681 CFKISVDCLWRESTEVFARDSPITVSDSTESNEATPSKKHNSCYERVCSALEARGHSYAP 1740
            CFKISVDCLWRESTEVFARDSPITVSDSTESNEATPSKKHNSCYERVCSALEARGHSYAP
Sbjct: 1681 CFKISVDCLWRESTEVFARDSPITVSDSTESNEATPSKKHNSCYERVCSALEARGHSYAP 1740

Query: 1741 DN 1742
            DN
Sbjct: 1741 DN 1742


>gi|169234742 NACHT and WD repeat domain containing 1 [Homo sapiens]
          Length = 1429

 Score =  221 bits (563), Expect = 5e-57
 Identities = 261/1088 (23%), Positives = 461/1088 (42%), Gaps = 136/1088 (12%)

Query: 338  YIEGLGKQFYEDMIDIIQATIQ-----QNFDT---ETDTLYDEILQHSSLCKTYASFYEY 389
            Y++ LG+QF      +++A  Q     +  DT   E   LY EI  H          +  
Sbjct: 126  YLKELGEQF------VVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCG 179

Query: 390  KCESLNIVHNYILPSKAGHINPLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVV 449
            + E L  +   +    +    PL+++G P  GKT L+ ++A++    L   T      V 
Sbjct: 180  RQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKT------VT 233

Query: 450  IVRFLGTTDMSSDLRTLLLSVCEQLAVNYRCLVQSYPKKIHD----LCDLFINLLNESSL 505
            ++R LGT+ MSSD R LL S+C Q+ + Y   +   P ++ D    +   F  LL+  S 
Sbjct: 234  VLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLP--PAQVLDAHTRVVQFFHTLLHTVSC 291

Query: 506  QR--PLVIIFDALEQLSENDDARKLWWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEE 563
            +    LV++ DA++ L     AR++ WLP + P  V ++LS      G+L  L+ ++ + 
Sbjct: 292  RNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDP 351

Query: 564  DNYIELIPRDRKMCSQVLKHQLLRVKRKVTSGQQIYVNNALSKCTLPMFVNLTFREVRHW 623
            + Y E+ P       Q+++  L   +R ++      +  +L +C  P  + L F E R W
Sbjct: 352  EAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKW 411

Query: 624  RSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLAL 683
             S        L+ T  E+  QL   LE+  GQ LV+  LGYI  ++ GLSE EL+DVL+L
Sbjct: 412  ASF--TVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSL 469

Query: 684  DNSVMSELKENTRPSNP--LRVPYLYIARLKEGLSGYLIERHVKNVTLLVWANRHLQLIA 741
            D+ V+ ++  +  P +   LR P L   RL+  L  YL  R V   TLL  A+R L  + 
Sbjct: 470  DDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVV 529

Query: 742  QKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLENRSLLEEEKHFM 801
            ++ YL   ++  + H +LAD+F G WS G +K   L  P +   L+L             
Sbjct: 530  RERYL-SGSERAKRHGVLADFFSGTWSQGTKKLITL--PLVGKPLNL------------- 573

Query: 802  EQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDLLYGIIMNFSWL 861
                 DR+   QP  F            N RK+ EL YHL   G+ ++L   ++ + SW+
Sbjct: 574  -----DRKVAPQPLWFSHT-------VANLRKLKELPYHLLHSGRLEELKQEVLGSMSWI 621

Query: 862  YTMIKIGQFDKVLSDIELAYNYSQEKELKFLANTLRSIKNKVT---AFPGSLSAELQQRL 918
                  G  + +L D +L   +    E+  +   L+  +  V         L  EL  RL
Sbjct: 622  SCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARL 681

Query: 919  LPVVSSLPKLRHLLLECDKDGPKYCS---IVPLHSSMDVTYSPERLPLSSSHLHVTEILP 975
                +S P L   L +  +   + C+   +VPL   +     P R  LS  H  +T +  
Sbjct: 682  HFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAW 741

Query: 976  TCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTNNTLLI 1035
                  ++   ++G ++ WD+E + ++  +T     +  +K+ +       A+ + TL +
Sbjct: 742  GVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHL 801

Query: 1036 YDNVNSCLLSEVEIKGTKHGSSATYINGFTLSANHALAWLEASKDVTVIDLLYGWPLYQF 1095
            ++     LLS  E               FT+       W   SK+     +   W L+  
Sbjct: 802  WN-----LLSGQE--------------KFTI-------WDGGSKNPAEPQI---WNLH-- 830

Query: 1096 HCWYEVTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEFSGGFVKFLLILDTAQ 1155
                    V  +   +Y+  G  +N    ++L + E +  +  + S  ++  + +L +  
Sbjct: 831  --------VDEAHKVVYSASGSKINA---WNLETAEPVFHILGDASDPWM-CMAVLASQA 878

Query: 1156 EMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSEDQSAVLICKALSIELL 1215
             ++ V  +G +S+W++      Q        +E++   ++ + +    V      SI L+
Sbjct: 879  TLLTVSRDGVVSLWSSA-TGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLV 937

Query: 1216 DTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFW-RRDTGQCMASLQEIS 1274
             +   ++ EK       RF+  V+S++   + A    +  +F    R   + MA   E  
Sbjct: 938  SSKGDRLLEKL--PDAVRFL--VVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHE 993

Query: 1275 GSIVKLVKSSHHNMLLSLSTSGVLSIWDI-DIITAMSNIDKTGKPIQSLLLPARGEIIYS 1333
              +   V  + +N++++ S   ++ +W + +  T +  ++  G P+   LL   G ++ S
Sbjct: 994  DMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVS--LLARGGALVAS 1051

Query: 1334 LDGSDCVHK-WNFSSGFIEAVFKHEGIVEHCVLTSTGDIMVTSD----------DKSSQY 1382
                    K W+ S         H   V    L  TG   V+ +          DK+   
Sbjct: 1052 ASPQSSSFKVWDLSDA-------HRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVT 1104

Query: 1383 VWHTSSGE 1390
            +W  + GE
Sbjct: 1105 IWDLAEGE 1112


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 53/184 (28%), Positives = 77/184 (41%), Gaps = 18/184 (9%)

Query: 31   PSHLVPAG----RSVRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYW 86
            PS L P      RS+R+FIS+   D   ER  L  +V P L+      + +    IDL W
Sbjct: 885  PSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAP-HRISLHGIDLRW 943

Query: 87   GVEEDEWDSPELQKTRMKLLENCL-KTSAGPCFVGLLGEKYGNI----RIPGEVEASEFE 141
            GV E+E         R + LE CL +      FVG+LG +YG I     +P        +
Sbjct: 944  GVTEEE-------TRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQ 996

Query: 142  MILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKSEMLRSNRNAMQPSTNAENEKTWQ 201
                     ++E         R + S  A  Y R  S  L S  +A +    +E+E+  +
Sbjct: 997  QYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFR-DSSFLSSVPDAWKSDFVSESEEAAR 1055

Query: 202  EISD 205
             IS+
Sbjct: 1056 RISE 1059



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 59/280 (21%), Positives = 121/280 (43%), Gaps = 16/280 (5%)

Query: 413  IIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLLSVCE 472
            ++ G    GKT  LA +       L    G +   +V   F G         TLL  +C 
Sbjct: 1165 LVTGQSGQGKTAFLASLVSA----LQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCT 1220

Query: 473  QLAVNYR---CLVQSYPKKIHDLCDLFINLLNESSLQ-RPLVIIFDALEQLSENDDARKL 528
             L    +    L  +Y   + +L    +    ES    +  V+I D  ++L + +     
Sbjct: 1221 YLRGQLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQLIS 1280

Query: 529  WWLPAHLPRFVRIVLSTLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRV 588
             W+P  LPR V +VLS + +  G+ + L     +  + + L P +    +++++ +L   
Sbjct: 1281 DWIPKKLPRCVHLVLS-VSSDAGLGETLE--QSQGAHVLALGPLEASARARLVREELALY 1337

Query: 589  KRKVTS---GQQIYVNNALSKCTLPMFVNLTFREVRHWRSHKDVDE--SSLSVTVHESIE 643
             +++       Q+ +     +   P+++ L    +R +  ++ V E   +L  TV   ++
Sbjct: 1338 GKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVPLLLQ 1397

Query: 644  QLFWSLEKKCGQKLVSRALGYITMAKMGLSEMELEDVLAL 683
             +  +LEK+ G  ++ +AL  + + + GL+  +L  VL++
Sbjct: 1398 HILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSV 1437



 Score = 39.7 bits (91), Expect = 0.026
 Identities = 56/266 (21%), Positives = 102/266 (38%), Gaps = 36/266 (13%)

Query: 1144 FVKFLLILDTAQEMVMVDSEG-SLSVWNTEDISSPQLTDDFDC----RREDSEVVSIELS 1198
            F K +L L T+QE++   SE  ++ +W  + ++ P   +DF C    R  +  V     S
Sbjct: 2011 FQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFS 2070

Query: 1199 EDQSAVLIC-KALSIELLDTGLWK---VAEKFRAKHNERFISAVLSKNGDCIIATMENTS 1254
             D  ++    +  S+   D    K   +   F A H +       +K  D ++ +  +  
Sbjct: 2071 TDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK--DNLLISCSSDG 2128

Query: 1255 AVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWD------------ 1302
            +V  W  ++GQ +        ++  +     H  ++S+S  G L +WD            
Sbjct: 2129 SVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVELTSIPAH 2186

Query: 1303 ---IDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWN-FSSGFIEAVFKHEG 1358
               I    A       G+P   LL+   G     LDG+     W+         +  H G
Sbjct: 2187 SGPISHCAAAMEPRAAGQPGSELLVVTVG-----LDGA--TRLWHPLLVCQTHTLLGHSG 2239

Query: 1359 IVEHCVLTSTGDIMVTSDDKSSQYVW 1384
             V    ++ T  +M+T+ +  S  +W
Sbjct: 2240 PVRAAAVSETSGLMLTASEDGSVRLW 2265


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 30/138 (21%), Positives = 52/138 (37%)

Query: 1247 IATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDII 1306
            + T      +  W   TG C  SL     SI   +     +M+ S    GV  +WD   +
Sbjct: 493  LLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKL 552

Query: 1307 TAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLT 1366
              + +ID    P   +   + G ++    G+  +H  +  SG I  +  HE      V +
Sbjct: 553  LPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFS 612

Query: 1367 STGDIMVTSDDKSSQYVW 1384
              G+I+ +     +   W
Sbjct: 613  HDGEILFSGGSDGTVRTW 630



 Score = 33.5 bits (75), Expect = 1.9
 Identities = 23/98 (23%), Positives = 41/98 (41%), Gaps = 2/98 (2%)

Query: 1248 ATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIIT 1307
            ++++ TS +  W  ++ +C  +L   + S+  +      N LL+ S    LSIWD     
Sbjct: 454  SSLDKTSKI--WDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511

Query: 1308 AMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNF 1345
               ++      I   +   RG +I S D       W+F
Sbjct: 512  CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDF 549


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
            sapiens]
          Length = 589

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 10/183 (5%)

Query: 1259 WRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKP 1318
            W  +TGQC+  L     + V+ V+     ++ S +   ++ +WD +  T +  +      
Sbjct: 368  WDIETGQCLHVLMGHVAA-VRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR 425

Query: 1319 IQSLLLPARGEIIYSLDGSDCVHKWNFSSG-FIEAVFKHEGIVEHCVLTSTGDIMVTSDD 1377
            + SL       +  SLD S  +  W+  +G  I  +  H+ +     L    +I+V+ + 
Sbjct: 426  VYSLQFDGIHVVSGSLDTS--IRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNA 481

Query: 1378 KSSQYVWHTSSGENLFRINGQRISQLLIT---HNDQFVVSLCEENASRVWRLATGHRVCN 1434
             S+  +W   +G+ L  + G    Q  +T    N  FV++  ++   ++W L TG  + N
Sbjct: 482  DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN 541

Query: 1435 ILT 1437
            ++T
Sbjct: 542  LVT 544



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 7/72 (9%)

Query: 990  SISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTNNTLLIYD-NVNSCLLSEVE 1048
            SI  WDVET   +  +T  QS+  GM+L   +  LV    ++T+ I+D     CL +   
Sbjct: 444  SIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQT--- 498

Query: 1049 IKG-TKHGSSAT 1059
            ++G  KH S+ T
Sbjct: 499  LQGPNKHQSAVT 510



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 17/69 (24%), Positives = 38/69 (55%), Gaps = 9/69 (13%)

Query: 978  NPSTVLTALENGSISTWDVETRQLLRQITTAQS-----VILGMKLTSDEKYLVVATTNNT 1032
            N + V+T+ ++G++  WD++T + +R + T +S     V+  ++ ++ +    V + N T
Sbjct: 515  NKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 574

Query: 1033 ----LLIYD 1037
                LL+ D
Sbjct: 575  EETKLLVLD 583


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
            sapiens]
          Length = 707

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 10/183 (5%)

Query: 1259 WRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKP 1318
            W  +TGQC+  L     + V+ V+     ++ S +   ++ +WD +  T +  +      
Sbjct: 486  WDIETGQCLHVLMGHVAA-VRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR 543

Query: 1319 IQSLLLPARGEIIYSLDGSDCVHKWNFSSG-FIEAVFKHEGIVEHCVLTSTGDIMVTSDD 1377
            + SL       +  SLD S  +  W+  +G  I  +  H+ +     L    +I+V+ + 
Sbjct: 544  VYSLQFDGIHVVSGSLDTS--IRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNA 599

Query: 1378 KSSQYVWHTSSGENLFRINGQRISQLLIT---HNDQFVVSLCEENASRVWRLATGHRVCN 1434
             S+  +W   +G+ L  + G    Q  +T    N  FV++  ++   ++W L TG  + N
Sbjct: 600  DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN 659

Query: 1435 ILT 1437
            ++T
Sbjct: 660  LVT 662



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 7/72 (9%)

Query: 990  SISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTNNTLLIYD-NVNSCLLSEVE 1048
            SI  WDVET   +  +T  QS+  GM+L   +  LV    ++T+ I+D     CL +   
Sbjct: 562  SIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQT--- 616

Query: 1049 IKG-TKHGSSAT 1059
            ++G  KH S+ T
Sbjct: 617  LQGPNKHQSAVT 628



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 17/69 (24%), Positives = 38/69 (55%), Gaps = 9/69 (13%)

Query: 978  NPSTVLTALENGSISTWDVETRQLLRQITTAQS-----VILGMKLTSDEKYLVVATTNNT 1032
            N + V+T+ ++G++  WD++T + +R + T +S     V+  ++ ++ +    V + N T
Sbjct: 633  NKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692

Query: 1033 ----LLIYD 1037
                LL+ D
Sbjct: 693  EETKLLVLD 701


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
            sapiens]
          Length = 627

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 10/183 (5%)

Query: 1259 WRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKP 1318
            W  +TGQC+  L     + V+ V+     ++ S +   ++ +WD +  T +  +      
Sbjct: 406  WDIETGQCLHVLMGHVAA-VRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNR 463

Query: 1319 IQSLLLPARGEIIYSLDGSDCVHKWNFSSG-FIEAVFKHEGIVEHCVLTSTGDIMVTSDD 1377
            + SL       +  SLD S  +  W+  +G  I  +  H+ +     L    +I+V+ + 
Sbjct: 464  VYSLQFDGIHVVSGSLDTS--IRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNA 519

Query: 1378 KSSQYVWHTSSGENLFRINGQRISQLLIT---HNDQFVVSLCEENASRVWRLATGHRVCN 1434
             S+  +W   +G+ L  + G    Q  +T    N  FV++  ++   ++W L TG  + N
Sbjct: 520  DSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN 579

Query: 1435 ILT 1437
            ++T
Sbjct: 580  LVT 582



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 7/72 (9%)

Query: 990  SISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVATTNNTLLIYD-NVNSCLLSEVE 1048
            SI  WDVET   +  +T  QS+  GM+L   +  LV    ++T+ I+D     CL +   
Sbjct: 482  SIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQT--- 536

Query: 1049 IKG-TKHGSSAT 1059
            ++G  KH S+ T
Sbjct: 537  LQGPNKHQSAVT 548



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 17/69 (24%), Positives = 38/69 (55%), Gaps = 9/69 (13%)

Query: 978  NPSTVLTALENGSISTWDVETRQLLRQITTAQS-----VILGMKLTSDEKYLVVATTNNT 1032
            N + V+T+ ++G++  WD++T + +R + T +S     V+  ++ ++ +    V + N T
Sbjct: 553  NKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 612

Query: 1033 ----LLIYD 1037
                LL+ D
Sbjct: 613  EETKLLVLD 621


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 55/287 (19%), Positives = 102/287 (35%), Gaps = 42/287 (14%)

Query: 1230 HNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNML 1289
            H +     VL  NG  +I+   +T+ V  W    G CM++L+     +  L  +    ++
Sbjct: 74   HTDWVNDIVLCCNGKTLISASSDTT-VKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELV 132

Query: 1290 LSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGF 1349
             S      + +WD++ +TA++  + T   + +  L    + IYSL               
Sbjct: 133  ASAGLDRQIFLWDVNTLTALTASNNT---VTTSSLSGNKDSIYSL--------------- 174

Query: 1350 IEAVFKHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGENLFRING--QRISQLLITH 1407
                           +   G I+V+   +    VW   +   L ++ G    +  LL+  
Sbjct: 175  --------------AMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNR 220

Query: 1408 NDQFVVSLCEENASRVWRLATGHRVCNILTTLQNAFITSANTFVV----GMTKSKVLAVS 1463
            +    +S   +   R+W L     +       +  +    N        G    K+    
Sbjct: 221  DGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTD 280

Query: 1464 LWTGSITKKFCCEDGTTIVNFKL--IPDCPDIIVFITSAETVNIWSL 1508
            L    I +   CE+   ++  +L    D P  I   T+  TVN W+L
Sbjct: 281  LRNPDI-RVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTL 326


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 51/257 (19%), Positives = 98/257 (38%), Gaps = 14/257 (5%)

Query: 1228 AKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHN 1287
            A H +   S   S NG+ + A+      +  W    G+   ++      I  +  SS  N
Sbjct: 42   AGHTKAVSSVKFSPNGEWL-ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1288 MLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSS 1347
            +L+S S    L IWD+     +  +      +       +  +I S    + V  W+  +
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1348 G-FIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGE---NLFRINGQRISQL 1403
            G  ++ +  H   V        G ++V+S       +W T+SG+    L   +   +S +
Sbjct: 161  GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220

Query: 1404 LITHNDQFVVSLCEENASRVW--------RLATGHRVCNILTTLQNAFITSANTFVVGMT 1455
              + N +++++   +N  ++W        +  TGH+         N  +T     V G  
Sbjct: 221  KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK-NEKYCIFANFSVTGGKWIVSGSE 279

Query: 1456 KSKVLAVSLWTGSITKK 1472
             + V   +L T  I +K
Sbjct: 280  DNLVYIWNLQTKEIVQK 296



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 25/122 (20%), Positives = 51/122 (41%), Gaps = 18/122 (14%)

Query: 980  STVLTALENGSISTWDVETRQLLRQITTAQSVILG-MKLTSDEKYLVVATTNNTLLIYD- 1037
            S ++++  +G    WD  + Q L+ +    +  +  +K + + KY++ AT +NTL ++D 
Sbjct: 184  SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 1038 -------------NVNSCLLSEVEIKGTK---HGSSATYINGFTLSANHALAWLEASKDV 1081
                         N   C+ +   + G K    GS    +  + L     +  L+   DV
Sbjct: 244  SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303

Query: 1082 TV 1083
             +
Sbjct: 304  VI 305


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 51/257 (19%), Positives = 98/257 (38%), Gaps = 14/257 (5%)

Query: 1228 AKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHN 1287
            A H +   S   S NG+ + A+      +  W    G+   ++      I  +  SS  N
Sbjct: 42   AGHTKAVSSVKFSPNGEWL-ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1288 MLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSS 1347
            +L+S S    L IWD+     +  +      +       +  +I S    + V  W+  +
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1348 G-FIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGE---NLFRINGQRISQL 1403
            G  ++ +  H   V        G ++V+S       +W T+SG+    L   +   +S +
Sbjct: 161  GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220

Query: 1404 LITHNDQFVVSLCEENASRVW--------RLATGHRVCNILTTLQNAFITSANTFVVGMT 1455
              + N +++++   +N  ++W        +  TGH+         N  +T     V G  
Sbjct: 221  KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK-NEKYCIFANFSVTGGKWIVSGSE 279

Query: 1456 KSKVLAVSLWTGSITKK 1472
             + V   +L T  I +K
Sbjct: 280  DNLVYIWNLQTKEIVQK 296



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 25/122 (20%), Positives = 51/122 (41%), Gaps = 18/122 (14%)

Query: 980  STVLTALENGSISTWDVETRQLLRQITTAQSVILG-MKLTSDEKYLVVATTNNTLLIYD- 1037
            S ++++  +G    WD  + Q L+ +    +  +  +K + + KY++ AT +NTL ++D 
Sbjct: 184  SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 1038 -------------NVNSCLLSEVEIKGTK---HGSSATYINGFTLSANHALAWLEASKDV 1081
                         N   C+ +   + G K    GS    +  + L     +  L+   DV
Sbjct: 244  SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303

Query: 1082 TV 1083
             +
Sbjct: 304  VI 305


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
            sapiens]
          Length = 472

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 54/289 (18%), Positives = 111/289 (38%), Gaps = 48/289 (16%)

Query: 1165 SLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSEDQSAVLIC---KALSIELLDTG--L 1219
            ++ +W+  D S   +  DF+  R  + VV   ++ D S V+     K +    L+TG  L
Sbjct: 125  TVKLWDPVDGS---VVRDFE-HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL 180

Query: 1220 WKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVK 1279
            WKV      +++   +S   S +G  +++  +          D G C+   + I+   V 
Sbjct: 181  WKV------RYDTFIVSCKFSPDGKYVVSGFDV---------DHGICIMDAENIT--TVS 223

Query: 1280 LVKSSHHNMLLS------------LSTSGVLSIWDIDIITAMSNIDKT-GKPIQSLLLPA 1326
            ++K  H   + S            +S    + IWD+     +  I K     I +     
Sbjct: 224  VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTF 283

Query: 1327 RGEIIYSLDGSDCVHKWNFSSG-------FIEAVFKHEGIVEHCVLTSTGDIMVTSDDKS 1379
             G  + +      +  WN  +G        +  +  HEG V  C        +++     
Sbjct: 284  SGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDR 343

Query: 1380 SQYVWHTSSGENLFRINGQR--ISQLLITHNDQFVVSLCEENASRVWRL 1426
            +  +W  + G     + G    +  + I++N ++++S  ++   R+W +
Sbjct: 344  TVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNI 392



 Score = 38.5 bits (88), Expect = 0.058
 Identities = 30/145 (20%), Positives = 59/145 (40%), Gaps = 11/145 (7%)

Query: 1298 LSIWDIDIITAMSNI-DKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSG--FIEAVF 1354
            + I D + IT +S I D   + I S       + + S+    C+  W+ +S    +    
Sbjct: 211  ICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITK 270

Query: 1355 KHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGE--------NLFRINGQRISQLLIT 1406
             H   + +C  T +G  + TS    +  +W+  +GE         L + +   +S     
Sbjct: 271  AHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFA 330

Query: 1407 HNDQFVVSLCEENASRVWRLATGHR 1431
             +  F++S   +    +W +A G+R
Sbjct: 331  RDSSFLISGGFDRTVAIWDVAEGYR 355



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 2/92 (2%)

Query: 970  VTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILGMKLTSDEKYLVVA-T 1028
            V E   T + S V+ A  + ++  WD+ET +LL ++    + I+  K + D KY+V    
Sbjct: 148  VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFD 206

Query: 1029 TNNTLLIYDNVNSCLLSEVEIKGTKHGSSATY 1060
             ++ + I D  N   +S ++   T+  +S  +
Sbjct: 207  VDHGICIMDAENITTVSVIKDHHTRSITSCCF 238


>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 72/350 (20%), Positives = 123/350 (35%), Gaps = 42/350 (12%)

Query: 1127 LGSGEKLCTVTSEFSGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCR 1186
            +G G     V ++  GG + +L +    Q ++    +G+  +W+T D     L       
Sbjct: 1    MGGGGSALRVCADHRGG-INWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQG---- 55

Query: 1187 REDSEVVSIELSEDQSAVLICKALSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCI 1246
              +S V   +L ED++A       +I   D    +  + +R   +   ++ +L  N    
Sbjct: 56   -HESYVTFCQL-EDEAAFTCSADCTIRRWDVLTGQCLQVYRG--HTSIVNRILVANNQLF 111

Query: 1247 IATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDII 1306
             ++ + T+ V  W  D GQ     +             H N +L+L+ S     WD+   
Sbjct: 112  SSSYDRTARV--WSVDKGQMSREFR------------GHRNCVLTLAYSAP---WDLPST 154

Query: 1307 TAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFK-HEGIVEHCVL 1365
                     G  +             S DG+  V  W  +SG      + H G V   VL
Sbjct: 155  PCAEEAAAGGLLVTG-----------STDGTAKV--WQVASGCCHQTLRGHTGAVLCLVL 201

Query: 1366 TSTGDIMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWR 1425
             + G    T    ++   W   SGE L      R S + +   ++ V S   +   + W 
Sbjct: 202  DTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWL 261

Query: 1426 LATGHRVCNILTTLQN--AFITSANTFVVGMTKSKVLAVSLWTGSITKKF 1473
              TG  V       +N  A    A T   G   +   A    +G + + F
Sbjct: 262  ADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVF 311


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
            sapiens]
          Length = 513

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 41/207 (19%), Positives = 78/207 (37%), Gaps = 11/207 (5%)

Query: 1101 VTCVQCSLDGLYAFCGQYLNTTTIFHLGSGEKLCTVTSEFSG--GFVKFLLILDTAQEMV 1158
            VTC+  S D        +  T  I  L SG+ L     EF G   FV           ++
Sbjct: 310  VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL----KEFRGHSSFVNEATFTQDGHYII 365

Query: 1159 MVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVS--IELSEDQSAVLICKALSIELLD 1216
               S+G++ +WN +                    V+  I L ++    ++C   +  ++ 
Sbjct: 366  SASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIM 425

Query: 1217 TGLWKVAEKFRAKHNER--FISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEIS 1274
                ++   F +   E   F+   LS  G+ I    E+   ++ +   TG+   +L    
Sbjct: 426  NMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDF-VLYCFSTVTGKLERTLTVHE 484

Query: 1275 GSIVKLVKSSHHNMLLSLSTSGVLSIW 1301
              ++ +    H N++ + S  G+L +W
Sbjct: 485  KDVIGIAHHPHQNLIATYSEDGLLKLW 511


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 40/212 (18%), Positives = 83/212 (39%), Gaps = 8/212 (3%)

Query: 1224 EKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKS 1283
            EK    HN        S +   +++  ++ + +  W   +G+C+ +L+  S  +     +
Sbjct: 76   EKTLYGHNLEISDVAWSSDSSRLVSASDDKT-LKLWDVRSGKCLKTLKGHSNYVFCCNFN 134

Query: 1284 SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKW 1343
               N+++S S    + IW++     +  +     P+ ++     G +I S         W
Sbjct: 135  PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194

Query: 1344 NFSSG--FIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGENLFRINGQRIS 1401
            + +SG      V      V     +  G  ++T+   ++  +W  S G  L    G +  
Sbjct: 195  DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254

Query: 1402 QLLITHN-----DQFVVSLCEENASRVWRLAT 1428
            +  I  N      +++VS  E+N   +W L T
Sbjct: 255  KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 286



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 31/147 (21%), Positives = 60/147 (40%), Gaps = 25/147 (17%)

Query: 955  TYSPERLPLSSSHLHVTEILPTCNPSTVLTALENGSISTWDVETRQLLRQITTAQSVILG 1014
            T S    P+S+ H +       C+ S +++   +G    WD  + Q L+ +    +  + 
Sbjct: 162  TLSAHSDPVSAVHFN-------CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214

Query: 1015 -MKLTSDEKYLVVATTNNTLLIYD--------------NVNSCLLSEVEIKGTK---HGS 1056
             +K + + KY++ AT +NTL ++D              N   C+ +   + G K    GS
Sbjct: 215  FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274

Query: 1057 SATYINGFTLSANHALAWLEASKDVTV 1083
                +  + L     +  L+   DV +
Sbjct: 275  EDNLVYIWNLQTKEIVQKLQGHTDVVI 301


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 35/170 (20%), Positives = 67/170 (39%), Gaps = 11/170 (6%)

Query: 1210 LSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMAS 1269
            + I +   G  +  + F+   NE  ++A+       ++A+  +   +  W      C+  
Sbjct: 341  MCIHVCRLGCDRPVKTFQGHTNE--VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 398

Query: 1270 LQEISGSIVKLVKS---------SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            LQ  +  I  +  S         + + ML S S    + +WDI+       + K  +P+ 
Sbjct: 399  LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 458

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370
            S+     G+ + S     CVH WN  SG +   ++  G +      + GD
Sbjct: 459  SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGD 508


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 35/170 (20%), Positives = 67/170 (39%), Gaps = 11/170 (6%)

Query: 1210 LSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMAS 1269
            + I +   G  +  + F+   NE  ++A+       ++A+  +   +  W      C+  
Sbjct: 341  MCIHVCRLGCDRPVKTFQGHTNE--VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 398

Query: 1270 LQEISGSIVKLVKS---------SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            LQ  +  I  +  S         + + ML S S    + +WDI+       + K  +P+ 
Sbjct: 399  LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 458

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370
            S+     G+ + S     CVH WN  SG +   ++  G +      + GD
Sbjct: 459  SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGD 508


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 35/170 (20%), Positives = 67/170 (39%), Gaps = 11/170 (6%)

Query: 1210 LSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMAS 1269
            + I +   G  +  + F+   NE  ++A+       ++A+  +   +  W      C+  
Sbjct: 392  MCIHVCRLGCDRPVKTFQGHTNE--VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449

Query: 1270 LQEISGSIVKLVKS---------SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            LQ  +  I  +  S         + + ML S S    + +WDI+       + K  +P+ 
Sbjct: 450  LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370
            S+     G+ + S     CVH WN  SG +   ++  G +      + GD
Sbjct: 510  SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGD 559


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 35/170 (20%), Positives = 67/170 (39%), Gaps = 11/170 (6%)

Query: 1210 LSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMAS 1269
            + I +   G  +  + F+   NE  ++A+       ++A+  +   +  W      C+  
Sbjct: 392  MCIHVCRLGCDRPVKTFQGHTNE--VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449

Query: 1270 LQEISGSIVKLVKS---------SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            LQ  +  I  +  S         + + ML S S    + +WDI+       + K  +P+ 
Sbjct: 450  LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370
            S+     G+ + S     CVH WN  SG +   ++  G +      + GD
Sbjct: 510  SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGD 559


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 40/210 (19%), Positives = 81/210 (38%), Gaps = 5/210 (2%)

Query: 1220 WKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVK 1279
            WK+ E     H     S VL K    ++AT  +   V  W  +   C+ SL   +  +  
Sbjct: 11   WKLQEI--VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68

Query: 1280 LVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDC 1339
            +  ++   ++++ S SG + +WD++    +  +      I SL     GE + S      
Sbjct: 69   VRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTN 128

Query: 1340 VHKWNF-SSGFIEAVFKHEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGENLFRINGQ 1398
            +  W+    G +     H   V     +  G  + ++ D  +  +W  ++G+ +    G 
Sbjct: 129  IKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGH 188

Query: 1399 R--ISQLLITHNDQFVVSLCEENASRVWRL 1426
               ++ +    N+  + S   +   R W L
Sbjct: 189  TGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218



 Score = 34.7 bits (78), Expect = 0.83
 Identities = 36/187 (19%), Positives = 77/187 (41%), Gaps = 13/187 (6%)

Query: 1151 LDTAQEMVMVDSE-GSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSEDQSAVLICKA 1209
            L+T +E+++  S+ GS+ VW+ E     +           + + S++       V    A
Sbjct: 71   LNTPEELIVAGSQSGSIRVWDLEAAKILRTL-----MGHKANICSLDFHPYGEFV----A 121

Query: 1210 LSIELLDTGLWKVAEK---FRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQC 1266
               +  +  LW +  K   FR + + + +  +        +A+  +   V  W    G+ 
Sbjct: 122  SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181

Query: 1267 MASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPA 1326
            M+     +G +  +    +  +L S S+   +  WD++    +S I+    P++S+L   
Sbjct: 182  MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241

Query: 1327 RGEIIYS 1333
             G  +YS
Sbjct: 242  DGCCLYS 248


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 33/138 (23%), Positives = 66/138 (47%), Gaps = 11/138 (7%)

Query: 409 INPLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLL 468
           I PL++ GGP +GK+LLL++       W+        + +++  F+G    +S   +L++
Sbjct: 523 IPPLLVSGGPGSGKSLLLSK-------WIQLQQKNSPNTLILSHFVGRPMSTSSESSLII 575

Query: 469 SVCEQLAVNYRCLVQSYPKKIHDLCDLFINLLNESSL--QRPLVIIFDALEQLSENDDAR 526
                  + +   V +       L + F   L + S   Q  ++I+ D+++Q+ + +   
Sbjct: 576 KRLTLKLMQHSWSVSALTLDPAKLLEEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHM 635

Query: 527 KLWWLPAHLPRFVRIVLS 544
           K  WL   LP  VR+++S
Sbjct: 636 K--WLIDPLPVNVRVIVS 651


>gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo
            sapiens]
          Length = 542

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 41/196 (20%), Positives = 88/196 (44%), Gaps = 13/196 (6%)

Query: 1239 LSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVL 1298
            L  + + II+ + + S +  W + + +C+  L   +GS++ L       ++++ S+   +
Sbjct: 246  LQYDDEKIISGLRDNS-IKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTV 302

Query: 1299 SIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEG 1358
             +WD++    ++ +    + +  L       +  S D S  V  W+ +S     +     
Sbjct: 303  RVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASA--TDITLRRV 358

Query: 1359 IVEHCVLTSTGD-----IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVV 1413
            +V H    +  D     I+  S D++ + VW TS+ E +  +NG +     + + D+ VV
Sbjct: 359  LVGHRAAVNVVDFDDKYIVSASGDRTIK-VWSTSTCEFVRTLNGHKRGIACLQYRDRLVV 417

Query: 1414 SLCEENASRVWRLATG 1429
            S   +N  R+W +  G
Sbjct: 418  SGSSDNTIRLWDIECG 433


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
            sapiens]
          Length = 514

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 34/170 (20%), Positives = 67/170 (39%), Gaps = 11/170 (6%)

Query: 1210 LSIELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMAS 1269
            + I +   G  +  + F+   NE  ++A+       ++A+  +   +  W      C+  
Sbjct: 329  MCIHVCKLGQDRPIKTFQGHTNE--VNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHD 386

Query: 1270 LQEISGSIVKLVKS---------SHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQ 1320
            LQ  +  I  +  S         + + ML S S    + +WD+D    +  + K  +P+ 
Sbjct: 387  LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446

Query: 1321 SLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD 1370
            S+     G  + S     CVH WN  +G +   ++  G +      + GD
Sbjct: 447  SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGD 496


>gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo
            sapiens]
          Length = 508

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 41/196 (20%), Positives = 88/196 (44%), Gaps = 13/196 (6%)

Query: 1239 LSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVL 1298
            L  + + II+ + + S +  W + + +C+  L   +GS++ L       ++++ S+   +
Sbjct: 212  LQYDDEKIISGLRDNS-IKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTV 268

Query: 1299 SIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEG 1358
             +WD++    ++ +    + +  L       +  S D S  V  W+ +S     +     
Sbjct: 269  RVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASA--TDITLRRV 324

Query: 1359 IVEHCVLTSTGD-----IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVV 1413
            +V H    +  D     I+  S D++ + VW TS+ E +  +NG +     + + D+ VV
Sbjct: 325  LVGHRAAVNVVDFDDKYIVSASGDRTIK-VWSTSTCEFVRTLNGHKRGIACLQYRDRLVV 383

Query: 1414 SLCEENASRVWRLATG 1429
            S   +N  R+W +  G
Sbjct: 384  SGSSDNTIRLWDIECG 399


>gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo
            sapiens]
          Length = 529

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 41/196 (20%), Positives = 88/196 (44%), Gaps = 13/196 (6%)

Query: 1239 LSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVL 1298
            L  + + II+ + + S +  W + + +C+  L   +GS++ L       ++++ S+   +
Sbjct: 233  LQYDDEKIISGLRDNS-IKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTV 289

Query: 1299 SIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEG 1358
             +WD++    ++ +    + +  L       +  S D S  V  W+ +S     +     
Sbjct: 290  RVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASA--TDITLRRV 345

Query: 1359 IVEHCVLTSTGD-----IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVV 1413
            +V H    +  D     I+  S D++ + VW TS+ E +  +NG +     + + D+ VV
Sbjct: 346  LVGHRAAVNVVDFDDKYIVSASGDRTIK-VWSTSTCEFVRTLNGHKRGIACLQYRDRLVV 404

Query: 1414 SLCEENASRVWRLATG 1429
            S   +N  R+W +  G
Sbjct: 405  SGSSDNTIRLWDIECG 420


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 43/206 (20%), Positives = 83/206 (40%), Gaps = 18/206 (8%)

Query: 1230 HNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGSIVKLVKSSHH--- 1286
            H+   IS   + +GD II T      V  W  DTG+    +  + G   ++  +S +   
Sbjct: 218  HSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGR---KVNILIGHCAEISSASFNWDC 273

Query: 1287 NMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIY--SLDGSDCVHKWN 1344
            +++L+ S      +WD      ++ +      I        G++I   S DG+  +    
Sbjct: 274  SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARI---- 329

Query: 1345 FSSGFIEAVFK---HEGIVEHCVLTSTGDIMVTSDDKSSQYVWHTSSGENLFRING--QR 1399
            FS+   + + K   HEG +        G+ ++T     +  +W   +G+ L  + G    
Sbjct: 330  FSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDE 389

Query: 1400 ISQLLITHNDQFVVSLCEENASRVWR 1425
            I      +    V++  ++N  R+WR
Sbjct: 390  IFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score = 33.5 bits (75), Expect = 1.9
 Identities = 44/225 (19%), Positives = 84/225 (37%), Gaps = 16/225 (7%)

Query: 1213 ELLDTGLWKVAEKFRAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQE 1272
            +L DT   +         N  +  A  +  GD I AT         W  +TG+C  + + 
Sbjct: 117  KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI-ATGSFDKTCKLWSVETGKCYHTFRG 175

Query: 1273 ISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNIDKTGKPIQSLLLPARGEIIY 1332
             +  IV L  +    ++ + S      +WDI     +  +      I SL     G+ I 
Sbjct: 176  HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235

Query: 1333 SLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD-------IMVTSDDKSSQYVWH 1385
            +      V  W+  +G      K   ++ HC   S+         I+  S DK+ + +W 
Sbjct: 236  TGSFDHTVVVWDADTG-----RKVNILIGHCAEISSASFNWDCSLILTGSMDKTCK-LWD 289

Query: 1386 TSSGENLFRING--QRISQLLITHNDQFVVSLCEENASRVWRLAT 1428
             ++G+ +  + G    I      +  + + +   +  +R++  AT
Sbjct: 290  ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 18/127 (14%)

Query: 342 LGKQFYEDMIDIIQATIQQNF----------DTETDTLYDEILQHSSLCKTYASFYEYKC 391
           +G +   D    I +T + NF          D +    YD I   SS  K      E   
Sbjct: 314 IGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPL 373

Query: 392 ESLNIVHNYILPSKAGHINPLIIYGGPCTGKTLLLAEVAKKAYGWLHEDTGPESDPVVIV 451
           +   +  +Y +P+  G    +++YG P TGKT++   VA +   ++    GPE    +I 
Sbjct: 374 KQPELFKSYGIPAPRG----VLLYGPPGTGKTMIARAVANEVGAYVSVINGPE----IIS 425

Query: 452 RFLGTTD 458
           +F G T+
Sbjct: 426 KFYGETE 432


>gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo
            sapiens]
          Length = 569

 Score = 41.2 bits (95), Expect = 0.009
 Identities = 38/181 (20%), Positives = 81/181 (44%), Gaps = 12/181 (6%)

Query: 1254 SAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNID 1313
            + +  W ++T +C   L   +GS++ L       ++++ S+   + +WD++    ++ + 
Sbjct: 287  NTIKIWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLI 344

Query: 1314 KTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD--- 1370
               + +  L       +  S D S  V  W+ +S     +     +V H    +  D   
Sbjct: 345  HHCEAVLHLRFNNGMMVTCSKDRSIAV--WDMASP--TDITLRRVLVGHRAAVNVVDFDD 400

Query: 1371 --IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLAT 1428
              I+  S D++ + VW+TS+ E +  +NG +     + + D+ VVS   +N  R+W +  
Sbjct: 401  KYIVSASGDRTIK-VWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIEC 459

Query: 1429 G 1429
            G
Sbjct: 460  G 460


>gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo
            sapiens]
          Length = 605

 Score = 41.2 bits (95), Expect = 0.009
 Identities = 38/181 (20%), Positives = 81/181 (44%), Gaps = 12/181 (6%)

Query: 1254 SAVFFWRRDTGQCMASLQEISGSIVKLVKSSHHNMLLSLSTSGVLSIWDIDIITAMSNID 1313
            + +  W ++T +C   L   +GS++ L       ++++ S+   + +WD++    ++ + 
Sbjct: 323  NTIKIWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLI 380

Query: 1314 KTGKPIQSLLLPARGEIIYSLDGSDCVHKWNFSSGFIEAVFKHEGIVEHCVLTSTGD--- 1370
               + +  L       +  S D S  V  W+ +S     +     +V H    +  D   
Sbjct: 381  HHCEAVLHLRFNNGMMVTCSKDRSIAV--WDMASP--TDITLRRVLVGHRAAVNVVDFDD 436

Query: 1371 --IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEENASRVWRLAT 1428
              I+  S D++ + VW+TS+ E +  +NG +     + + D+ VVS   +N  R+W +  
Sbjct: 437  KYIVSASGDRTIK-VWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIEC 495

Query: 1429 G 1429
            G
Sbjct: 496  G 496


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score = 40.0 bits (92), Expect = 0.020
 Identities = 64/258 (24%), Positives = 110/258 (42%), Gaps = 26/258 (10%)

Query: 61  ENVYPKLREFCRENYGLEFQVIDLYWGVEEDEWDSPELQKTRMKLLENCLKTSAGPCFVG 120
           E +  KL      N  L  +++ L   +EE E  +  LQK   +L E   K + G C   
Sbjct: 315 EEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNS 374

Query: 121 LLGEKYGNIRIPG-EVEASEFEMILDAAIEAKLETKLLEEWYCRDENSVPAAYYLRPKSE 179
            L  +  N+R    E+E  + E+    +   +L  KL EE +   E  +      +  SE
Sbjct: 375 SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE 434

Query: 180 M-------LRSNRNAMQPSTNAENEKT-WQEISDEIKKIFKAAVKLLHEKGKMKHSQAKR 231
           +        +S     Q   N E EK   +++ +E+ ++ K+ VK L    +   S+ ++
Sbjct: 435 LEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNEL-EVVKSRVKEL----ECSESRLEK 489

Query: 232 YLFSAIED-----EFDFALGKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMDITGTEP 286
              S  +D      F   L  +    ++K     RK+  + +  K+ E GK MD+T    
Sbjct: 490 AELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKV-EQGKVMDVT---E 545

Query: 287 RIIRDPEAQEKLIKLRDE 304
           ++I   E  +KL+KL+ E
Sbjct: 546 KLI---EESKKLLKLKSE 560


>gi|30520335 WD repeat domain 49 [Homo sapiens]
          Length = 697

 Score = 39.7 bits (91), Expect = 0.026
 Identities = 40/171 (23%), Positives = 72/171 (42%), Gaps = 9/171 (5%)

Query: 1227 RAKHNERFISAVLSKNGDCIIATMENTSAVFFWRRDTGQCMASLQEISGS--IVKLVKSS 1284
            R K +E+ ++ VL  +    + + +  S V FW  DTGQ +       G+  I  +   +
Sbjct: 143  RVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGNAEISTMALDA 202

Query: 1285 HHNMLLSLSTSGVLSIWDID-IITAMSNIDKTGK-PIQSLLLPARGEIIYSLDGSDCVHK 1342
            +   LL+ ST G + IWD +       N+ + G   I  +L+  +  ++   + +  V +
Sbjct: 203  NETRLLTGSTDGTVKIWDFNGYCHHTLNVGQDGAVDISQILILKKKILVTGWERAITVFR 262

Query: 1343 -WNFSSGFIEAVFKHEGIVEH----CVLTSTGDIMVTSDDKSSQYVWHTSS 1388
              NF+  FI+      GI  H    C        +VT        +W+ S+
Sbjct: 263  PQNFNQFFIQPEEWKGGIQHHDDILCAAFLPPQTLVTGSYDGEIVLWNNST 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,892,417
Number of Sequences: 37866
Number of extensions: 2813297
Number of successful extensions: 7061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 6730
Number of HSP's gapped (non-prelim): 329
length of query: 1742
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1626
effective length of database: 13,855,062
effective search space: 22528330812
effective search space used: 22528330812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.