BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|222352090 neural precursor cell expressed, developmentally down-regulated 4-like isoform 5 [Homo sapiens] (947 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|222352090 neural precursor cell expressed, developmentally do... 1964 0.0 gi|222352088 neural precursor cell expressed, developmentally do... 1952 0.0 gi|21361472 neural precursor cell expressed, developmentally dow... 1952 0.0 gi|222352086 neural precursor cell expressed, developmentally do... 1940 0.0 gi|222352094 neural precursor cell expressed, developmentally do... 1740 0.0 gi|222352092 neural precursor cell expressed, developmentally do... 1740 0.0 gi|222352183 neural precursor cell expressed, developmentally do... 1728 0.0 gi|222352084 neural precursor cell expressed, developmentally do... 1728 0.0 gi|222352082 neural precursor cell expressed, developmentally do... 1728 0.0 gi|114520609 neural precursor cell expressed, developmentally do... 1208 0.0 gi|114520607 neural precursor cell expressed, developmentally do... 986 0.0 gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 525 e-149 gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 524 e-148 gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 509 e-144 gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 484 e-136 gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 462 e-130 gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 456 e-128 gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 435 e-121 gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 430 e-120 gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104 gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 343 4e-94 gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 287 3e-77 gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 218 3e-56 gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 3e-52 gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 3e-52 gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 3e-52 gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 187 3e-47 gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 3e-46 gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 184 3e-46 gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 177 5e-44 >gi|222352090 neural precursor cell expressed, developmentally down-regulated 4-like isoform 5 [Homo sapiens] Length = 947 Score = 1964 bits (5089), Expect = 0.0 Identities = 947/947 (100%), Positives = 947/947 (100%) Query: 1 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 60 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK Sbjct: 1 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 60 Query: 61 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF Sbjct: 61 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120 Query: 121 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 180 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE Sbjct: 121 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 180 Query: 181 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 240 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR Sbjct: 181 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 240 Query: 241 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 300 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS Sbjct: 241 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 300 Query: 301 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP 360 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP Sbjct: 301 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP 360 Query: 361 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLS 420 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLS Sbjct: 361 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLS 420 Query: 421 SPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIA 480 SPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIA Sbjct: 421 SPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIA 480 Query: 481 PNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYID 540 PNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYID Sbjct: 481 PNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYID 540 Query: 541 HNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 600 HNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF Sbjct: 541 HNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 600 Query: 601 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 660 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT Sbjct: 601 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 660 Query: 661 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 720 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND Sbjct: 661 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 720 Query: 721 MESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYI 780 MESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYI Sbjct: 721 MESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYI 780 Query: 781 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSI 840 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSI Sbjct: 781 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSI 840 Query: 841 YKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 900 YKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE Sbjct: 841 YKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 900 Query: 901 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD Sbjct: 901 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 >gi|222352088 neural precursor cell expressed, developmentally down-regulated 4-like isoform 4 [Homo sapiens] Length = 967 Score = 1952 bits (5058), Expect = 0.0 Identities = 947/967 (97%), Positives = 947/967 (97%), Gaps = 20/967 (2%) Query: 1 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 60 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK Sbjct: 1 MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 60 Query: 61 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF Sbjct: 61 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 120 Query: 121 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 180 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE Sbjct: 121 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 180 Query: 181 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 240 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR Sbjct: 181 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 240 Query: 241 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 300 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS Sbjct: 241 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 300 Query: 301 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS----------- 349 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 301 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTV 360 Query: 350 ---------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS 400 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS Sbjct: 361 TGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS 420 Query: 401 ATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSP 460 ATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSP Sbjct: 421 ATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSP 480 Query: 461 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG 520 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG Sbjct: 481 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG 540 Query: 521 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL 580 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL Sbjct: 541 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL 600 Query: 581 KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWF 640 KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWF Sbjct: 601 KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWF 660 Query: 641 FLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLD 700 FLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLD Sbjct: 661 FLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLD 720 Query: 701 GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQV 760 GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQV Sbjct: 721 GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQV 780 Query: 761 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL 820 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL Sbjct: 781 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL 840 Query: 821 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 880 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV Sbjct: 841 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 900 Query: 881 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA 940 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA Sbjct: 901 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA 960 Query: 941 QGFEGVD 947 QGFEGVD Sbjct: 961 QGFEGVD 967 >gi|21361472 neural precursor cell expressed, developmentally down-regulated 4-like isoform 3 [Homo sapiens] Length = 955 Score = 1952 bits (5056), Expect = 0.0 Identities = 940/944 (99%), Positives = 943/944 (99%) Query: 4 LAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 63 L+ ++GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN Sbjct: 12 LSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 71 Query: 64 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 123 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF Sbjct: 72 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 131 Query: 124 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 183 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP Sbjct: 132 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 191 Query: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS Sbjct: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251 Query: 244 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 303 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL Sbjct: 252 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 311 Query: 304 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW 363 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW Sbjct: 312 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGW 371 Query: 364 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT 423 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT Sbjct: 372 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT 431 Query: 424 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG 483 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG Sbjct: 432 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG 491 Query: 484 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS 543 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS Sbjct: 492 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS 551 Query: 544 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 603 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES Sbjct: 552 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 611 Query: 604 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY 663 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY Sbjct: 612 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY 671 Query: 664 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES 723 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES Sbjct: 672 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES 731 Query: 724 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV 783 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV Sbjct: 732 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV 791 Query: 784 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN 843 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN Sbjct: 792 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN 851 Query: 844 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG 903 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG Sbjct: 852 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG 911 Query: 904 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD Sbjct: 912 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955 >gi|222352086 neural precursor cell expressed, developmentally down-regulated 4-like isoform 1 [Homo sapiens] Length = 975 Score = 1940 bits (5025), Expect = 0.0 Identities = 940/964 (97%), Positives = 943/964 (97%), Gaps = 20/964 (2%) Query: 4 LAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 63 L+ ++GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN Sbjct: 12 LSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLN 71 Query: 64 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 123 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF Sbjct: 72 PKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF 131 Query: 124 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 183 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP Sbjct: 132 LLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELP 191 Query: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS Sbjct: 192 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 251 Query: 244 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 303 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL Sbjct: 252 RRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL 311 Query: 304 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS-------------- 349 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 312 SRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGG 371 Query: 350 ------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 403 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN Sbjct: 372 EEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 431 Query: 404 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ 463 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ Sbjct: 432 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQ 491 Query: 464 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 523 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP Sbjct: 492 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 551 Query: 524 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 583 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP Sbjct: 552 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 611 Query: 584 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 643 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL Sbjct: 612 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 671 Query: 644 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 703 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF Sbjct: 672 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 731 Query: 704 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 763 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK Sbjct: 732 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 791 Query: 764 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 823 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL Sbjct: 792 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 851 Query: 824 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 883 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN Sbjct: 852 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 911 Query: 884 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF Sbjct: 912 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971 Query: 944 EGVD 947 EGVD Sbjct: 972 EGVD 975 >gi|222352094 neural precursor cell expressed, developmentally down-regulated 4-like isoform 6 [Homo sapiens] Length = 834 Score = 1740 bits (4507), Expect = 0.0 Identities = 834/834 (100%), Positives = 834/834 (100%) Query: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 353 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240 Query: 354 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 413 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300 Query: 414 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 473 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360 Query: 474 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 533 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420 Query: 534 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 593 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480 Query: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540 Query: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600 Query: 714 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 773 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660 Query: 774 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 833 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720 Query: 834 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780 Query: 894 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834 >gi|222352092 neural precursor cell expressed, developmentally down-regulated 4-like isoform 6 [Homo sapiens] Length = 834 Score = 1740 bits (4507), Expect = 0.0 Identities = 834/834 (100%), Positives = 834/834 (100%) Query: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 353 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240 Query: 354 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 413 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300 Query: 414 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 473 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360 Query: 474 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 533 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD 420 Query: 534 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 593 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK Sbjct: 421 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 480 Query: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG Sbjct: 481 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 540 Query: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG Sbjct: 541 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 600 Query: 714 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 773 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN Sbjct: 601 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN 660 Query: 774 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 833 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN Sbjct: 661 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN 720 Query: 834 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 893 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG Sbjct: 721 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG 780 Query: 894 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD Sbjct: 781 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834 >gi|222352183 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 934 LMAVENAQGFEGVD 947 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|222352084 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 934 LMAVENAQGFEGVD 947 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|222352082 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 934 LMAVENAQGFEGVD 947 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|114520609 neural precursor cell expressed, developmentally down-regulated 4 isoform 1 [Homo sapiens] Length = 900 Score = 1208 bits (3125), Expect = 0.0 Identities = 611/942 (64%), Positives = 715/942 (75%), Gaps = 56/942 (5%) Query: 7 EQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKW 66 ++ SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK+LNPKW Sbjct: 14 DEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKKSLNPKW 72 Query: 67 NEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLR 126 NEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTFKDF+L Sbjct: 73 NEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLH 132 Query: 127 PRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPP 186 PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q++ P P Sbjct: 133 PRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSP 192 Query: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246 LPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R F +RR Sbjct: 193 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRAFTTRRQ 249 Query: 247 ISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRR 306 ISE E E + + E WE I E+ + PPP ++ P L+EEL+ R Sbjct: 250 ISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLAEELNAR 304 Query: 307 LQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEER 366 L I +S Q +S SSR S EQ LP + T+ GLP GWEE+ Sbjct: 305 LTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLLPTSSGLPPGWEEK 357 Query: 367 KDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTL 426 +D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ + S S VT Sbjct: 358 QDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT- 413 Query: 427 SAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPF 486 QPS ++ Q FLP GWE+R APNGRPF Sbjct: 414 --------------------------QPS---------EIEQGFLPKGWEVRHAPNGRPF 438 Query: 487 FIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKI 545 FIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K Sbjct: 439 FIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKR 498 Query: 546 TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYR 605 TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYR Sbjct: 499 TQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYR 558 Query: 606 RIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTL 665 RIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTL Sbjct: 559 RIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTL 618 Query: 666 QINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVD 725 QINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVD Sbjct: 619 QINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVD 678 Query: 726 SEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 785 SEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQ Sbjct: 679 SEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738 Query: 786 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGY 845 WRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY Sbjct: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 798 Query: 846 CPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSP 905 NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+P Sbjct: 799 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTP 858 Query: 906 EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947 EKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD Sbjct: 859 EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900 >gi|114520607 neural precursor cell expressed, developmentally down-regulated 4 isoform 2 [Homo sapiens] Length = 1247 Score = 986 bits (2550), Expect = 0.0 Identities = 503/784 (64%), Positives = 583/784 (74%), Gaps = 55/784 (7%) Query: 165 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 224 GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++ Sbjct: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577 Query: 225 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 284 ++N Q+ A R F +RR ISE E E + + E WE I E+ + P Sbjct: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632 Query: 285 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 344 PP ++ P L+EEL+ RL I +S Q +S SSR S EQ Sbjct: 633 PPSSN---LDVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPT 686 Query: 345 LPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNS 404 LP + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S Sbjct: 687 LP----VLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742 Query: 405 NNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQH 464 + PQ + S S VT QPS Sbjct: 743 S---AGPQSQASTSDSGQQVT---------------------------QPS--------- 763 Query: 465 KVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLP 523 ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLP Sbjct: 764 EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLP 823 Query: 524 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKP 583 PGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK Sbjct: 824 PGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQ 883 Query: 584 ADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLL 643 DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+ Sbjct: 884 NDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLI 943 Query: 644 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFF 703 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFF Sbjct: 944 SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 1003 Query: 704 IRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK 763 IRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK Sbjct: 1004 IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELK 1063 Query: 764 PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELL 823 GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELL Sbjct: 1064 NGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELL 1123 Query: 824 MCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN 883 MCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMN Sbjct: 1124 MCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMN 1183 Query: 884 GFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 GFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF Sbjct: 1184 GFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243 Query: 944 EGVD 947 +GVD Sbjct: 1244 DGVD 1247 >gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo sapiens] Length = 922 Score = 525 bits (1352), Expect = e-149 Identities = 342/931 (36%), Positives = 491/931 (52%), Gaps = 104/931 (11%) Query: 55 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 112 TKT K + NPKW+E+ V P L F+V+ L D LG+ + L Sbjct: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101 Query: 113 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 171 K LL RVK +LK++ KNG Q E + D + E + + Sbjct: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151 Query: 172 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 226 S+ + + L E R T ++++ T+ + S D Sbjct: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211 Query: 227 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 273 N +Q AA + + L EP++ G+ T +SEE Sbjct: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268 Query: 274 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 326 ++ + + PP +S + P +E E R + PD++ + SS + Sbjct: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328 Query: 327 SSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWT 386 S + C D V +Q T LPSGWE+RKD GRTYYV+HN RTTTW Sbjct: 329 SRQPDGCM--DPVRQQSGNA--------NTETLPSGWEQRKDPHGRTYYVDHNTRTTTWE 378 Query: 387 RPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPLEGAKDS 436 RP Q G + R + PT+ + L+GA Sbjct: 379 RP--QPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQ 436 Query: 437 PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTT 496 +R + ++ + + PY LPPGWE R+ R +F++HNTKTT Sbjct: 437 FNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNHNTKTTQ 483 Query: 497 WEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNP 556 WEDPR + + PLP GWE R +G +++DHN++ T ++DPR Sbjct: 484 WEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKS 532 Query: 557 AIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPD 614 ++T GP + Y R F+ K +FR + A +P+ ++ + R +FE+S+++IM++K D Sbjct: 533 SVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIMALKPYD 591 Query: 615 VLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLC 674 L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + Sbjct: 592 -LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI- 649 Query: 675 NEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKW 734 N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+ D+ES+D+E+YNSL W Sbjct: 650 NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIW 709 Query: 735 ILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRV 792 I +N+ E L++ F +D E G+ DLK GS I+VT ENK EYI L+ +WRF V Sbjct: 710 IRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGV 769 Query: 793 QKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVI 852 Q+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y N I Sbjct: 770 QEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQI 828 Query: 853 QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH 912 WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G LPR+H Sbjct: 829 IWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSH 888 Query: 913 TCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 TCFNRLDLPPY+++E L+EKLL A+E +GF Sbjct: 889 TCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919 >gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens] Length = 862 Score = 524 bits (1350), Expect = e-148 Identities = 296/723 (40%), Positives = 407/723 (56%), Gaps = 50/723 (6%) Query: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQEL 299 R + +S + +P + G + + +++ + PP P+ P T + Sbjct: 168 RSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPA 227 Query: 300 SEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE---QGHLPPPSVAYVHTT 356 S S T +S+G SL ++ + + + G P + V Sbjct: 228 SVNGSP--SATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQA 285 Query: 357 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRP 416 P LP GWE+R D GR YYV+H + TTW RP + G N R Sbjct: 286 P-LPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHFTRT 342 Query: 417 RSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSPKPQ 463 + PT+ + L+GA +R + +D + QS + P Sbjct: 343 TTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP---- 398 Query: 464 HKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 523 LPPGWE R NGR +F++HNT+ T WEDPR S+ LN PLP Sbjct: 399 -------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK---PLP 440 Query: 524 PGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKKLKK 582 GWE R +DG +++DHN + T + DPR A+ GP + Y R+FK K YFR ++ Sbjct: 441 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ 500 Query: 583 PADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL 642 A +P ++ + R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREWFFL Sbjct: 501 LA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREWFFL 558 Query: 643 LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGF 702 LS E+ NP Y LFEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK +D Sbjct: 559 LSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTG 617 Query: 703 FIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQTYQV 760 F PFYK +L K + L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ Sbjct: 618 FSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSH 677 Query: 761 DLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENEL 820 DLKPNG I+VT ENK EYI +V +WR V++Q AF EGF E+LP ++ FD EL Sbjct: 678 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKEL 737 Query: 821 ELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV 880 E+L+CG+ ++D+NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT R+ Sbjct: 738 EVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRL 796 Query: 881 PMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENA 940 P+ GFA+L GSNGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E Sbjct: 797 PVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856 Query: 941 QGF 943 +GF Sbjct: 857 EGF 859 Score = 67.4 bits (163), Expect = 6e-11 Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%) Query: 184 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 243 P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375 Query: 244 R-RHISEDL-----EPEPSEGGDVPEPWE 266 R + ++DL E G +P WE Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404 Score = 58.2 bits (139), Expect = 4e-08 Identities = 24/43 (55%), Positives = 30/43 (69%) Query: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216 + SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428 Score = 50.8 bits (120), Expect = 6e-06 Identities = 19/31 (61%), Positives = 23/31 (74%) Query: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216 PLPPGWE++VD GR YYV+H + T W RP Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316 Score = 38.9 bits (89), Expect = 0.023 Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%) Query: 162 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216 + H + D SQ Q L PLP GWE + G Y+V+HN RTT + P Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468 >gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sapiens] Length = 748 Score = 509 bits (1311), Expect = e-144 Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%) Query: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418 LP GWEER+ A GR Y+NH RTT W RP +E + G RP S Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203 Query: 419 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 478 V + P+ G + ++ L+ + N H T LP G+E R Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260 Query: 479 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 538 G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++ Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315 Query: 539 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 570 +DHN++ TQ+ DPRL +T P Y R+ Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373 Query: 571 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 630 QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432 Query: 631 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 690 DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491 Query: 691 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 749 +AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+ Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551 Query: 750 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 809 + +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611 Query: 810 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 869 L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670 Query: 870 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 928 LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730 Query: 929 LREKLLMAVENAQGF 943 L EKLL A+E GF Sbjct: 731 LYEKLLTAIEETCGF 745 Score = 87.0 bits (214), Expect = 7e-17 Identities = 106/406 (26%), Positives = 154/406 (37%), Gaps = 122/406 (30%) Query: 14 LRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFR 73 LR+ V+ +L KKD F DP+ K+ V D + + T T+K TL+PKWN+ + Sbjct: 14 LRLTVLCAKNLVKKDFFRLPDPFAKV---VVDGSGQCH--STDTVKNTLDPKWNQHYDLY 68 Query: 74 VNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSH 130 + S+ + V++ ++ + FLG V LL + Sbjct: 69 IGKSDS-VTISVWNHKKIHKKQGAGFLGCVR----------------------LLSNAIN 105 Query: 131 KSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPP 185 + + G+ RL + + N GQ + RD + G +VVD + L Sbjct: 106 RLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS--------RLFDN 157 Query: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI------- 229 LP GWEE+ GR Y+NH RTTQW RP+ +S D N Sbjct: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNG 217 Query: 230 ----RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE---TISEEVNIAGDSLGLA 282 + + A RR RS+RH + D+PE +E T +V G++ Sbjct: 218 ATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277 Query: 283 LPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ 342 P P++LS + N E E Sbjct: 278 TWHDP------RVPRDLS-----------NINCE------------------------EL 296 Query: 343 GHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388 G LPP GWE R A GR Y+V+HNNRTT +T P Sbjct: 297 GPLPP--------------GWEIRNTATGRVYFVDHNNRTTQFTDP 328 Score = 47.8 bits (112), Expect = 5e-05 Identities = 20/33 (60%), Positives = 24/33 (72%) Query: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218 PLPPGWE + GR Y+V+HNNRTTQ+ P L Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330 >gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 isoform 1 [Homo sapiens] Length = 870 Score = 484 bits (1246), Expect = e-136 Identities = 289/735 (39%), Positives = 400/735 (54%), Gaps = 88/735 (11%) Query: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 298 R R+ RH P+ G P + V +G S GLA P + T P+E Sbjct: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248 Query: 299 ----LSEELSRRLQITPDSN------------GEQFSSLIQREPSSRLRSCSVTDAVAEQ 342 ++ + L +TP+ N GE+ S+ ++ + ++ A EQ Sbjct: 249 SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQ 308 Query: 343 GHLPPPSVAYV-HTTPG------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 395 LP V YV H T LP GWE+R D +GR YYV+HN RTTTW RP + + Sbjct: 309 RELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRN 368 Query: 396 GASGSATNSN-----NHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 450 + + H + + + S S+ L G + V N + Sbjct: 369 YEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTR 428 Query: 451 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRS 510 + Q + P+ Q + + LPPGWEM+ G +F+DHNT+TTT++DPR Sbjct: 429 TTQ---WEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR--------- 476 Query: 511 KTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFK 570 PG+E + G Y R F+ Sbjct: 477 -------------PGFE---------------------------SGTKQGSPGAYDRSFR 496 Query: 571 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 630 KY FR A +P+ ++ + R +FE+S+++IM++K P L+ RL+I E+GL Sbjct: 497 WKYHQFRFLCHSNA-LPSHVKISVSRQTLFEDSFQQIMNMK-PYDLRRRLYIIMRGEEGL 554 Query: 631 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 690 DYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR Sbjct: 555 DYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIA 613 Query: 691 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFC 748 +A++HGK +D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F Sbjct: 614 MALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFI 673 Query: 749 IDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLP 808 D E G+ +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P Sbjct: 674 QDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAP 733 Query: 809 IDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRI 868 ++ ++ FDE ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRI Sbjct: 734 LEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRI 792 Query: 869 RLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFED 928 RLLQFVTGT R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E Sbjct: 793 RLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQ 852 Query: 929 LREKLLMAVENAQGF 943 LREKLL A+E +GF Sbjct: 853 LREKLLYAIEETEGF 867 Score = 87.0 bits (214), Expect = 7e-17 Identities = 65/226 (28%), Positives = 92/226 (40%), Gaps = 35/226 (15%) Query: 331 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 390 R S T E H PP + + G S A RT +R Sbjct: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220 Query: 391 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 446 + G SG A + N +P+ ++SP +APL +P ++ Sbjct: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276 Query: 447 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFP 505 + + +PS + + P LP GWE R PNGR +++DHNTKTTTWE P Sbjct: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP----- 331 Query: 506 VHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 551 LPPGWE+R GR +Y+DHN++ T W+ P Sbjct: 332 ----------------LPPGWEKRTDPRGRFYYVDHNTRTTTWQRP 361 Score = 59.7 bits (143), Expect = 1e-08 Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%) Query: 160 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 209 D + GWE VD N + + PLPPGWE++ D GR YYV+HN R Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354 Query: 210 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 266 TT W RP+ V + ++ + A + F R + S + G +P WE Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412 Score = 57.0 bits (136), Expect = 8e-08 Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 41/228 (17%) Query: 170 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 224 + + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKR 339 Query: 225 SDNNIRQINQEAAHRRFRSRRHISE---DLEPEPSEGGDVPEPWETISEEVNIAGDSLGL 281 +D R + R +R +E + E S+ + + S+ S Sbjct: 340 TDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAST 399 Query: 282 ALPP-PPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVA 340 P P PG E ++ R + ++ Q+ +P + Sbjct: 400 DHDPLGPLPPG-----WEKRQDNGRVYYVNHNTRTTQW-----EDPRT------------ 437 Query: 341 EQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388 QG + P+ LP GWE + ++G Y+V+HN RTTT+ P Sbjct: 438 -QGMIQEPA---------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475 Score = 42.7 bits (99), Expect = 0.002 Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 55/223 (24%) Query: 41 LYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQV 100 +Y D N +T T ++ L P W + R +P F D N T Sbjct: 316 VYYVDHN-----TKTTTWERPLPPGWEK----RTDPRGR---FYYVDHNTRTTT------ 357 Query: 101 DVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR---LKMAYMPKNGGQDEENSD 157 + PT E ++ + +S +++++G ++ + Y + D D Sbjct: 358 --------WQRPTAEYVRNYEQW----QSQRNQLQGAMQHFSQRFLYQSSSASTDH---D 402 Query: 158 QRDDMEHGWE---------VVDSNDSASQHQEE-----LPPPPLPPGWEEKVDNLGRTYY 203 + GWE V+ N +Q ++ + P LPPGWE K + G Y+ Sbjct: 403 PLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYF 462 Query: 204 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246 V+HN RTT + D ++ +Q + A R FR + H Sbjct: 463 VDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWKYH 500 >gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo sapiens] Length = 731 Score = 462 bits (1188), Expect = e-130 Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%) Query: 444 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 503 D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+ Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268 Query: 504 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 555 R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL + Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323 Query: 556 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 600 P+ PA Y R+ QK R +L +++ R IF Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383 Query: 601 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 660 EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442 Query: 661 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 720 + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501 Query: 721 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 779 +ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561 Query: 780 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 839 + L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++ Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621 Query: 840 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 896 K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680 Query: 897 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728 Score = 47.4 bits (111), Expect = 6e-05 Identities = 20/33 (60%), Positives = 24/33 (72%) Query: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218 PLPPGWE + GR Y+V+HNNRTTQ+ P L Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313 Score = 46.6 bits (109), Expect = 1e-04 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%) Query: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418 LP GWE R GR Y+V+HNNRTT +T P + +H++ Q + Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 322 Query: 419 LSSPTVTLSAPLEGA---KDSPVRRAVKD 444 L P+ L P EG+ ++ P +R +D Sbjct: 323 LKEPSQPLPLPSEGSLEDEELPAQRYERD 351 Score = 43.9 bits (102), Expect = 7e-04 Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 5/62 (8%) Query: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68 G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+ Sbjct: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64 Query: 69 EF 70 + Sbjct: 65 HY 66 Score = 30.4 bits (67), Expect = 8.2 Identities = 10/34 (29%), Positives = 19/34 (55%) Query: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218 P LP G+E++ G+ Y+++ + WH P + Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267 >gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo sapiens] Length = 757 Score = 456 bits (1173), Expect = e-128 Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%) Query: 444 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 503 D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+ Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268 Query: 504 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 542 P R S+N ++LGPLPPGWE R + GR +++DHN Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328 Query: 543 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 579 ++ TQ+ DPRL + P+ PA Y R+ QK R + Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388 Query: 580 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 639 L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447 Query: 640 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 699 +LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG + Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506 Query: 700 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 758 +G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+ Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566 Query: 759 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 818 Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+ Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626 Query: 819 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 878 ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++ Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685 Query: 879 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 934 RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745 Query: 935 MAVENAQGF 943 AVE GF Sbjct: 746 TAVEETCGF 754 Score = 61.2 bits (147), Expect = 4e-09 Identities = 104/464 (22%), Positives = 172/464 (37%), Gaps = 124/464 (26%) Query: 9 GESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNE 68 G S +R+ V+ +LAKKD F DP+ K+ V D + + T T+K TL+PKWN+ Sbjct: 10 GSSIKIRLTVLCAKNLAKKDFFRLPDPFAKI---VVDGSGQCH--STDTVKNTLDPKWNQ 64 Query: 69 EFYFRVNPSNHRLLFEVFDENRLTRDD---FLGQVDVPLSHLPTEDPTMERPYTFKDFLL 125 + V ++ + V++ ++ + FLG V LL Sbjct: 65 HYDLYVGKTD-SITISVWNHKKIHKKQGAGFLGCVR----------------------LL 101 Query: 126 RPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDS----NDSAS 176 + + G+ RL + + + GQ + RD + G VVD + + Sbjct: 102 SNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGT 161 Query: 177 QHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEA 236 +++ P PL EE T ++ N R + + Sbjct: 162 VYEDSGPGRPLSCFMEEPAPYTDST-------------------GAAAGGGNCRFVESPS 202 Query: 237 AHRRFRSRRHISEDL---------EPEPSEGGDVPEPWE---TISEEVNIAGDSLGLALP 284 +R +++R + D+ P + ++PE +E T+ +V G++ Sbjct: 203 QDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTW 262 Query: 285 PPPASPG-SRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQG 343 P P S T P + L + L+Q S SV E G Sbjct: 263 HDPRIPSPSGTIPGGDAAFL--------------YEFLLQGHTSEPRDLNSVN--CDELG 306 Query: 344 HLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATN 403 LPP GWE R GR Y+V+HNNRTT +T P + Sbjct: 307 PLPP--------------GWEVRSTVSGRIYFVDHNNRTTQFTDPRL------------- 339 Query: 404 SNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 444 +H++ Q + L P+ L P EG+ ++ P +R +D Sbjct: 340 --HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 377 >gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 isoform 2 [Homo sapiens] Length = 431 Score = 435 bits (1118), Expect = e-121 Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%) Query: 522 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 579 LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66 Query: 580 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 639 A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW Sbjct: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124 Query: 640 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 699 FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK + Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183 Query: 700 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 757 D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+ Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243 Query: 758 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 817 +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303 Query: 818 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 877 ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362 Query: 878 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 937 R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+ Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422 Query: 938 ENAQGF 943 E +GF Sbjct: 423 EETEGF 428 Score = 42.0 bits (97), Expect = 0.003 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%) Query: 185 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 244 P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR + Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59 Query: 245 RH 246 H Sbjct: 60 YH 61 Score = 40.8 bits (94), Expect = 0.006 Identities = 16/32 (50%), Positives = 22/32 (68%) Query: 357 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388 P LP GWE + ++G Y+V+HN RTTT+ P Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36 >gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Homo sapiens] Length = 1572 Score = 430 bits (1106), Expect = e-120 Identities = 285/788 (36%), Positives = 419/788 (53%), Gaps = 58/788 (7%) Query: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 244 LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866 Query: 245 RHISEDLEPEPS----EGGDVPEPWETISEEV---NIAGDS-----LGLALPPPPASPGS 292 R + PE + +G + S + NI S + L L PP Sbjct: 867 RRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVK--F 924 Query: 293 RTSPQ---ELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS 349 SP+ L S T ++ + + ++R+ R D V G L Sbjct: 925 LISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLV---GFLN--- 978 Query: 350 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLI 409 + + LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL Sbjct: 979 -MFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT 1036 Query: 410 EPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVT 467 R RS S+ V + G P + +T+S PQ P YN K+ Sbjct: 1037 -----RQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV 1086 Query: 468 QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWE 527 +FL I +P +++ + R + + +S DL L +E Sbjct: 1087 -AFLRQPNIFEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFE 1143 Query: 528 ERIHLDGRTFYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRK 578 E I + H S + P Q PA PY R+F+ K F + Sbjct: 1144 EEIMSYVPPHALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYR 1202 Query: 579 KL--KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA 636 KL K P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G + Sbjct: 1203 KLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPS 1262 Query: 637 REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHG 696 RE+FFL+S+E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H Sbjct: 1263 REFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQ 1321 Query: 697 KLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFG 755 LLD FF RPFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FG Sbjct: 1322 YLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFG 1381 Query: 756 QTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIF 815 Q + +LKP G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +F Sbjct: 1382 QITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVF 1441 Query: 816 DENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVT 875 D ELEL++ G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVT Sbjct: 1442 DARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVT 1501 Query: 876 GTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLM 935 GTS +P GFA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL Sbjct: 1502 GTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLT 1561 Query: 936 AVENAQGF 943 AVE F Sbjct: 1562 AVEETSTF 1569 Score = 71.6 bits (174), Expect = 3e-12 Identities = 88/343 (25%), Positives = 121/343 (35%), Gaps = 105/343 (30%) Query: 254 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 308 EP+ G P E E V AG + +P P A + +EL E RR Sbjct: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742 Query: 309 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPP---PSVA---- 351 + + S Q E S+ + A A++ GH P PSV Sbjct: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800 Query: 352 -YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP--------------IMQLAE-- 394 Y LP WE R D+ GR +YV+H NRTTTW RP I Q+ + Sbjct: 801 RYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLN 860 Query: 395 -------------------DGASGSATNSNNHLIEPQIRR----PRSLSSPTVTLSAPLE 431 + G+ ++ H RR P S S +TL Sbjct: 861 RRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLL---- 916 Query: 432 GAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------------------- 467 + PV+ + PS Y N+ +H +T Sbjct: 917 -LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVG 975 Query: 468 --------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 502 Q LP GWEM+ G+ FF+DHN++TTT+ DPRL Sbjct: 976 FLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018 Score = 32.7 bits (73), Expect = 1.6 Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 12/126 (9%) Query: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79 KK +F DPY+K+S+ ++ ++ I T NP W+ E Y Sbjct: 198 KKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTD 257 Query: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136 L E+ F ++R FLG++ +P+ L ++ ++ P H V G Sbjct: 258 VLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADH---VSG 314 Query: 137 FLRLKM 142 +L+ K+ Sbjct: 315 YLQFKV 320 >gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] Length = 1606 Score = 378 bits (971), Expect = e-104 Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%) Query: 551 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 608 P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268 Query: 609 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 668 + R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+ Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328 Query: 669 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 728 P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+ Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387 Query: 729 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 787 + SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447 Query: 788 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 847 V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507 Query: 848 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 907 H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567 Query: 908 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 LPRAHTCFNRLDLPPY ++ L EKLL AVE F Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603 Score = 71.6 bits (174), Expect = 3e-12 Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%) Query: 270 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 326 EE N A +S+ ++ P P S +EL S ++ +P E S + Sbjct: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795 Query: 327 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 383 + R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT Sbjct: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855 Query: 384 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 430 TW RP DG S + N I+ I RS S AP Sbjct: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915 Query: 431 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 490 G DS + + +L + SP NS K+T P ++ N F + H Sbjct: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968 Query: 491 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 530 T +T + LK F + ++ +N + LP GWE + Sbjct: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028 Query: 531 HLDGRTFYIDHNSKITQWEDPRL 553 G++F++DHNS+ T + DPR+ Sbjct: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051 Score = 66.2 bits (160), Expect = 1e-10 Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%) Query: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 245 PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R + Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886 Query: 246 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 303 +I + E SE + E+ G G + +S S +E LS Sbjct: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942 Query: 304 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 341 S+++ + S N E F+ L + R+ + S + Sbjct: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002 Query: 342 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 401 L + T LP GWE + D +G++++V+HN+R TT+ P + L +G Sbjct: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058 Query: 402 TNSNNHLIEPQIRRPRSLSS 421 N H ++R RS S+ Sbjct: 1059 PNHLTH--RQHLQRLRSYSA 1076 Score = 47.0 bits (110), Expect = 8e-05 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%) Query: 467 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 526 T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062 Query: 527 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 585 R HL R++ S++++ L + P + ++ + P Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114 Query: 586 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 644 ++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174 Score = 41.6 bits (96), Expect = 0.004 Identities = 63/286 (22%), Positives = 111/286 (38%), Gaps = 28/286 (9%) Query: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79 KK +F DPY+K+S+ + AL ++K I T+NP W E + V+ Sbjct: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277 Query: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136 L EV F ++R FLG++ +P+ L +R ++ P H V G Sbjct: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334 Query: 137 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 195 L+ + DEE S + + N+ E P P E K Sbjct: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393 Query: 196 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 252 + LG + N++ + RP+ ++ D + + E A + +D++ Sbjct: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450 Query: 253 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE 298 P PS E ++E++++ ++ L L A ++ P E Sbjct: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLE 488 >gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] Length = 4374 Score = 343 bits (880), Expect = 4e-94 Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%) Query: 568 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 625 +F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051 Query: 626 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 685 E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+ Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110 Query: 686 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 743 GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170 Query: 744 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 803 DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230 Query: 804 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 863 E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289 Query: 864 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 922 R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349 Query: 923 YETFEDLREKLLMAV-ENAQGF 943 YE+FE LR LL+A+ E ++GF Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371 >gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [Homo sapiens] Length = 909 Score = 287 bits (735), Expect = 3e-77 Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%) Query: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653 +HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614 Query: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713 LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672 Query: 714 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 771 + D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732 Query: 772 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 831 T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792 Query: 832 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 891 V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852 Query: 892 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 937 +G Q FTI +P LP + TC N L LP Y + E L+++LL+A+ Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899 >gi|87116668 hypothetical protein LOC9870 [Homo sapiens] Length = 823 Score = 218 bits (554), Expect = 3e-56 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%) Query: 566 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 620 S F+ K ++F+++L K+P ++ +K+ R+ + E S + + D K Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491 Query: 621 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 680 + F+ E+ LD+GG REWF L+ K +F+ LF + +N L ++PN L Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550 Query: 681 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 732 + F GR+ G ++ L + F R F ++G ++ E+ D E+Y S + Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610 Query: 733 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 788 +IL ND +E++L+F EE + ++ Q+D L G++ VTN NK Y++L+ Q+R Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668 Query: 789 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 847 ++V++++ FL+G EL+P +L+ IFDENELELLMCG GD+ V+D++ H++ G + Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728 Query: 848 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 907 V++WFW V + E+ RLLQF TG+S++P GFA L S F I + Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783 Query: 908 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 943 LP AHTCFN+L LP Y+++E++ L +A+ E +GF Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820 >gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] Length = 872 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581 Query: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636 Query: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696 Query: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756 Query: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816 Query: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867 Query: 942 GF 943 GF Sbjct: 868 GF 869 >gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] Length = 852 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561 Query: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616 Query: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676 Query: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736 Query: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796 Query: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847 Query: 942 GF 943 GF Sbjct: 848 GF 849 >gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] Length = 875 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584 Query: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639 Query: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699 Query: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759 Query: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819 Query: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870 Query: 942 GF 943 GF Sbjct: 871 GF 872 >gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] Length = 1083 Score = 187 bits (476), Expect = 3e-47 Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%) Query: 563 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 615 +P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747 Query: 616 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 670 LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805 Query: 671 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 727 + + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865 Query: 728 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 785 Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925 Query: 786 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 844 +R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985 Query: 845 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 904 Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040 Query: 905 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 944 E+LP A TC N L LP + LR KLL A+E A GFE Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081 >gi|7657152 hect domain and RLD 3 [Homo sapiens] Length = 1050 Score = 184 bits (468), Expect = 3e-46 Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%) Query: 592 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 651 + + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP Sbjct: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762 Query: 652 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 711 YG+F Y N S C +H ++F IG GLA+++ ++D F YK + Sbjct: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817 Query: 712 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 767 L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G Sbjct: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877 Query: 768 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 827 + V +N++E++D + + F V + AF GF ++ ++++F +EL +M G Sbjct: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937 Query: 828 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 887 + + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A Sbjct: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997 Query: 888 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF Sbjct: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047 >gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] Length = 776 Score = 184 bits (467), Expect = 3e-46 Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%) Query: 592 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 651 MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476 Query: 652 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 711 YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK + Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531 Query: 712 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 754 L I T++D+ + E + L +L ++ + F + +E F Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591 Query: 755 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 814 G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + + Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651 Query: 815 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 874 E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710 Query: 875 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 934 TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+ Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764 Query: 935 MAVENAQGF 943 + + N++GF Sbjct: 765 IGISNSEGF 773 >gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] Length = 1049 Score = 177 bits (448), Expect = 5e-44 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%) Query: 594 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 653 + R NI ++ + K D K L + F E +D GGV +E+F L+ +E+ +P YG Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763 Query: 654 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 713 +F Y D+ + + + + F IG + GLA+++ ++D F YK +L Sbjct: 764 MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818 Query: 714 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 769 K+ +L+D++ + + S++ +L+ +++ FC++ ENFG T +L NG++ Sbjct: 819 KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878 Query: 770 MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 829 V +N++E++D + + F V +AF GF ++ ++ +F NEL+ ++ G + Sbjct: 879 AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938 Query: 830 VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 889 D + +++ YK Y HP I+ FW+ + EK+ + L F+TG+ R+P+ G L Sbjct: 939 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997 Query: 890 GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943 +L G E LP +HTCFN LDLP Y E LR KL+ A+++ +GF Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.135 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 42,278,776 Number of Sequences: 37866 Number of extensions: 2268328 Number of successful extensions: 11077 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 159 Number of HSP's successfully gapped in prelim test: 194 Number of HSP's that attempted gapping in prelim test: 9639 Number of HSP's gapped (non-prelim): 1078 length of query: 947 length of database: 18,247,518 effective HSP length: 112 effective length of query: 835 effective length of database: 14,006,526 effective search space: 11695449210 effective search space used: 11695449210 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.