BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|222352084 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] (854 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|222352183 neural precursor cell expressed, developmentally do... 1779 0.0 gi|222352088 neural precursor cell expressed, developmentally do... 1779 0.0 gi|222352086 neural precursor cell expressed, developmentally do... 1779 0.0 gi|222352084 neural precursor cell expressed, developmentally do... 1779 0.0 gi|222352082 neural precursor cell expressed, developmentally do... 1779 0.0 gi|21361472 neural precursor cell expressed, developmentally dow... 1728 0.0 gi|222352094 neural precursor cell expressed, developmentally do... 1728 0.0 gi|222352092 neural precursor cell expressed, developmentally do... 1728 0.0 gi|222352090 neural precursor cell expressed, developmentally do... 1728 0.0 gi|114520609 neural precursor cell expressed, developmentally do... 1056 0.0 gi|114520607 neural precursor cell expressed, developmentally do... 982 0.0 gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 529 e-150 gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 514 e-145 gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 509 e-144 gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 483 e-136 gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 462 e-130 gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 456 e-128 gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 435 e-121 gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 400 e-111 gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104 gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 343 4e-94 gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 287 3e-77 gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 218 2e-56 gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 204 3e-52 gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 204 3e-52 gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 204 3e-52 gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 187 3e-47 gi|7657152 hect domain and RLD 3 [Homo sapiens] 184 2e-46 gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 184 3e-46 gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 177 5e-44 >gi|222352183 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1779 bits (4609), Expect = 0.0 Identities = 854/854 (100%), Positives = 854/854 (100%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|222352088 neural precursor cell expressed, developmentally down-regulated 4-like isoform 4 [Homo sapiens] Length = 967 Score = 1779 bits (4609), Expect = 0.0 Identities = 854/854 (100%), Positives = 854/854 (100%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 353 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 354 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 413 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 414 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 473 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 474 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 533 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 534 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 593 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 594 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 653 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 654 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 713 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 714 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 773 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 774 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 833 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 834 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 893 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 894 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 953 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 954 LMAVENAQGFEGVD 967 >gi|222352086 neural precursor cell expressed, developmentally down-regulated 4-like isoform 1 [Homo sapiens] Length = 975 Score = 1779 bits (4609), Expect = 0.0 Identities = 854/854 (100%), Positives = 854/854 (100%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 361 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 362 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 421 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 422 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 481 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 482 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 541 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 542 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 601 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 602 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 661 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 662 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 721 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 722 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 781 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 782 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 841 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 842 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 901 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 902 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 961 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 962 LMAVENAQGFEGVD 975 >gi|222352084 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1779 bits (4609), Expect = 0.0 Identities = 854/854 (100%), Positives = 854/854 (100%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|222352082 neural precursor cell expressed, developmentally down-regulated 4-like isoform 2 [Homo sapiens] Length = 854 Score = 1779 bits (4609), Expect = 0.0 Identities = 854/854 (100%), Positives = 854/854 (100%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 841 LMAVENAQGFEGVD 854 >gi|21361472 neural precursor cell expressed, developmentally down-regulated 4-like isoform 3 [Homo sapiens] Length = 955 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 122 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 181 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 182 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 241 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 242 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 301 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 302 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 357 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 358 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 401 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 402 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 461 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 462 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 521 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 522 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 581 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 582 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 641 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 642 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 701 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 702 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 761 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 762 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 821 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 822 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 881 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 882 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 941 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 942 LMAVENAQGFEGVD 955 >gi|222352094 neural precursor cell expressed, developmentally down-regulated 4-like isoform 6 [Homo sapiens] Length = 834 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 821 LMAVENAQGFEGVD 834 >gi|222352092 neural precursor cell expressed, developmentally down-regulated 4-like isoform 6 [Homo sapiens] Length = 834 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 236 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 237 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 280 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 281 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 340 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 341 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 400 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 401 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 460 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 461 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 520 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 521 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 580 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 581 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 640 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 641 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 700 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 701 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 760 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 761 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 820 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 821 LMAVENAQGFEGVD 834 >gi|222352090 neural precursor cell expressed, developmentally down-regulated 4-like isoform 5 [Homo sapiens] Length = 947 Score = 1728 bits (4476), Expect = 0.0 Identities = 834/854 (97%), Positives = 834/854 (97%), Gaps = 20/854 (2%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND Sbjct: 114 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 173 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN Sbjct: 174 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 233 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR Sbjct: 234 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 293 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS Sbjct: 294 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS---- 349 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA Sbjct: 350 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 393 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ Sbjct: 394 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 453 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS Sbjct: 454 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 513 Query: 421 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 480 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY Sbjct: 514 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY 573 Query: 481 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 540 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG Sbjct: 574 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 633 Query: 541 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 600 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV Sbjct: 634 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV 693 Query: 601 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 660 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN Sbjct: 694 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN 753 Query: 661 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 720 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK Sbjct: 754 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK 813 Query: 721 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 780 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF Sbjct: 814 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 873 Query: 781 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 840 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL Sbjct: 874 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL 933 Query: 841 LMAVENAQGFEGVD 854 LMAVENAQGFEGVD Sbjct: 934 LMAVENAQGFEGVD 947 >gi|114520609 neural precursor cell expressed, developmentally down-regulated 4 isoform 1 [Homo sapiens] Length = 900 Score = 1056 bits (2732), Expect = 0.0 Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%) Query: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60 +ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D Sbjct: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179 Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120 +A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ Sbjct: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239 Query: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180 A R F +RR ISE E E + + E WE I E+ + PPP ++ Sbjct: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291 Query: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240 P L+EEL+ RL I +S +V+ + H + Sbjct: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325 Query: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300 R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q Sbjct: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384 Query: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360 + + +++ S+ PQ + S S VT Q Sbjct: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414 Query: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420 PS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS Sbjct: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465 Query: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479 L+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K Sbjct: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525 Query: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539 Y++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDY Sbjct: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585 Query: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599 GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A Sbjct: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645 Query: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659 V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE Sbjct: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705 Query: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719 FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI Sbjct: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765 Query: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779 KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQ Sbjct: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825 Query: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839 FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K Sbjct: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885 Query: 840 LLMAVENAQGFEGVD 854 L MA+EN QGF+GVD Sbjct: 886 LQMAIENTQGFDGVD 900 >gi|114520607 neural precursor cell expressed, developmentally down-regulated 4 isoform 2 [Homo sapiens] Length = 1247 Score = 982 bits (2539), Expect = 0.0 Identities = 501/804 (62%), Positives = 585/804 (72%), Gaps = 75/804 (9%) Query: 52 GWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111 GW V+D D+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++ Sbjct: 518 GWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTD 577 Query: 112 SDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP 171 ++N Q+ A R F +RR ISE E E + + E WE I E+ + P Sbjct: 578 AENGNIQLQ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSP 632 Query: 172 PPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGH 231 PP ++ P L+EEL+ RL I +S +V+ + H Sbjct: 633 PPSSN---LDVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH 669 Query: 232 LPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTT 291 + R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTT Sbjct: 670 ------SSRRGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTT 722 Query: 292 WTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKD 351 WT+P +Q + + +++ S+ PQ + S S VT Sbjct: 723 WTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT------------------- 760 Query: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411 QPS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK Sbjct: 761 --------QPS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKI 803 Query: 412 PVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV 470 P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAV Sbjct: 804 PAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAV 863 Query: 471 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE 530 PYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIE Sbjct: 864 PYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923 Query: 531 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT 590 F+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF Sbjct: 924 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983 Query: 591 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL 650 FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTEL Sbjct: 984 FIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL 1043 Query: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710 DL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF Sbjct: 1044 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 1103 Query: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770 EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD Sbjct: 1104 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 1163 Query: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY 830 +EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPY Sbjct: 1164 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPY 1223 Query: 831 ETFEDLREKLLMAVENAQGFEGVD 854 E+FE+L +KL MA+EN QGF+GVD Sbjct: 1224 ESFEELWDKLQMAIENTQGFDGVD 1247 >gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens] Length = 862 Score = 529 bits (1363), Expect = e-150 Identities = 294/666 (44%), Positives = 390/666 (58%), Gaps = 56/666 (8%) Query: 211 REPSSRLRSCSVTDAV--AEQGHLPPPS--------APAGRARSSTVTGGEEPTPSVAYV 260 R P+S S S T + G LPP + A +G T++GG P P Sbjct: 224 RRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPV- 282 Query: 261 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 320 T LP GWE+R D GR YYV+H + TTW RP + G N Sbjct: 283 -TQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVDHF 339 Query: 321 RRPRSLSSPTVTL----------SAPLEGAKDSPVRRAV---KDTLSNPQSPQPSPYNSP 367 R + PT+ + L+GA +R + +D + QS + P Sbjct: 340 TRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGP- 398 Query: 368 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG 427 LPPGWE R NGR +F++HNT+ T WEDPR S+ LN Sbjct: 399 ----------LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR--------SQGQLNEK--- 437 Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAI-TGPAVPYSREFKQKYDYFRKK 486 PLP GWE R +DG +++DHN + T + DPR A+ GP + Y R+FK K YFR Sbjct: 438 PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFW 497 Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546 ++ A +P ++ + R +FE+S+++IMS P L+ RLW+ F E+GLDYGGVAREW Sbjct: 498 CQQLA-MPQHIKITVTRKTLFEDSFQQIMSFS-PQDLRRRLWVIFPGEEGLDYGGVAREW 555 Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606 FFLLS E+ NP Y LFEY+ DNY LQINP S + N DHL YF FIGR +A+FHGK + Sbjct: 556 FFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFI 614 Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDL--MFCIDEENFGQT 664 D F PFYK +L K + L D+ES+D E+YNSL W+ EN+ E DL F +D+E G+ Sbjct: 615 DTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEI 674 Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724 DLKPNG I+VT ENK EYI +V +WR V++Q AF EGF E+LP ++ FD Sbjct: 675 KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDA 734 Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784 ELE+L+CG+ ++D+NDW++H+IY++ Y I WFW+ V +D EKR+RLLQFVTGT Sbjct: 735 KELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 793 Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844 R+P+ GFA+L GSNGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+ Sbjct: 794 CRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 853 Query: 845 ENAQGF 850 E +GF Sbjct: 854 EETEGF 859 Score = 67.4 bits (163), Expect = 5e-11 Identities = 35/89 (39%), Positives = 50/89 (56%), Gaps = 6/89 (6%) Query: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRS 130 P PLPPGWE +VDN+GR YYV+H RTT W RP+L V + +++ + A ++F Sbjct: 316 PEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQ 375 Query: 131 R-RHISEDL-----EPEPSEGGDVPEPWE 153 R + ++DL E G +P WE Sbjct: 376 RFIYGNQDLFATSQSKEFDPLGPLPPGWE 404 Score = 58.2 bits (139), Expect = 3e-08 Identities = 24/43 (55%), Positives = 30/43 (69%) Query: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 + SQ +E P PLPPGWE++ D+ GR Y+VNHN R TQW P Sbjct: 386 ATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428 Score = 50.8 bits (120), Expect = 5e-06 Identities = 19/31 (61%), Positives = 23/31 (74%) Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 PLPPGWE++VD GR YYV+H + T W RP Sbjct: 286 PLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP 316 Score = 38.9 bits (89), Expect = 0.020 Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%) Query: 49 MEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 + H + D SQ Q L PLP GWE + G Y+V+HN RTT + P Sbjct: 416 VNHNTRITQWEDPRSQGQ--LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468 >gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo sapiens] Length = 922 Score = 514 bits (1325), Expect = e-145 Identities = 276/623 (44%), Positives = 384/623 (61%), Gaps = 44/623 (7%) Query: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAE 301 A+S G +P + T LPSGWE+RKD GRTYYV+HN RTTTW RP Q Sbjct: 327 AKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP--QPLP 384 Query: 302 DGASGSATNSNNHLIEPQIRRPRSLSSPTV----------TLSAPLEGAKDSPVRRAVKD 351 G + R + PT+ + L+GA +R + Sbjct: 385 PGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS 444 Query: 352 TLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF 411 ++ + + PY LPPGWE R+ R +F++HNTKTT WEDPR + Sbjct: 445 --ASMLAAENDPYGP-----------LPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ- 490 Query: 412 PVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAIT--GPA 469 + PLP GWE R +G +++DHN++ T ++DPR ++T GP Sbjct: 491 ----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ 540 Query: 470 VPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWI 529 + Y R F+ K +FR + A +P+ ++ + R +FE+S+++IM++K D L+ RL++ Sbjct: 541 IAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYV 598 Query: 530 EFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF 589 F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +NY LQINP S + N DHLSYF Sbjct: 599 IFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYF 657 Query: 590 TFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE 649 FIGR +A+FHGK +D F PFYK ML K++T+ D+ES+D+E+YNSL WI +N+ E Sbjct: 658 CFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEE 717 Query: 650 --LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFL 707 L++ F +D E G+ DLK GS I+VT ENK EYI L+ +WRF VQ+Q AFL Sbjct: 718 CGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFL 777 Query: 708 EGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767 +GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++Y++ Y N I WFW+ V Sbjct: 778 DGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVK 836 Query: 768 LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDL 827 D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE+ G LPR+HTCFNRLDL Sbjct: 837 ETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDL 896 Query: 828 PPYETFEDLREKLLMAVENAQGF 850 PPY+++E L+EKLL A+E +GF Sbjct: 897 PPYKSYEQLKEKLLFAIEETEGF 919 Score = 67.8 bits (164), Expect = 4e-11 Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%) Query: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 +QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP Sbjct: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412 Query: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153 ++ V + ++ + A ++F R S L E G +P WE Sbjct: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463 Score = 57.8 bits (138), Expect = 4e-08 Identities = 23/45 (51%), Positives = 30/45 (66%) Query: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111 E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495 Score = 51.6 bits (122), Expect = 3e-06 Identities = 22/44 (50%), Positives = 25/44 (56%) Query: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 D Q LP GWE++ D GRTYYV+HN RTT W RP Sbjct: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380 Score = 37.4 bits (85), Expect = 0.060 Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%) Query: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 WE D Q++E PLP GWE + G Y+V+HN RTT + P Sbjct: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527 >gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sapiens] Length = 748 Score = 509 bits (1311), Expect = e-144 Identities = 272/615 (44%), Positives = 365/615 (59%), Gaps = 58/615 (9%) Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325 LP GWEER+ A GR Y+NH RTT W RP +E + G RP S Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG---------------RPLS 203 Query: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385 V + P+ G + ++ L+ + N H T LP G+E R Sbjct: 204 CF---VDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQR 260 Query: 386 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 445 G+ +F+ T +TW DPR+ R +++N +LGPLPPGWE R GR ++ Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRVP-----RDLSNINCEELGPLPPGWEIRNTATGRVYF 315 Query: 446 IDHNSKITQWEDPRLQ----------------------------NPAITGPAVPYSREFK 477 +DHN++ TQ+ DPRL +T P Y R+ Sbjct: 316 VDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLV 373 Query: 478 QKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL 537 QK R++L + +++ R IFEESYR++M ++ D+ K RL I+F E+GL Sbjct: 374 QKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGL 432 Query: 538 DYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAG 597 DYGGVAREW +LLS EM NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ G Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMG 491 Query: 598 LAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCI 656 +AVFHG +DG F PFYK +LGK ITL+DME VD + +NSL WILEND T LD FC+ Sbjct: 492 MAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCV 551 Query: 657 DEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716 + +G+ Q +LKPNG I V ENK+EY+ L + WRF+ ++ Q A +GF E++P Sbjct: 552 EHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQ 611 Query: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIR 776 L+K FDE ELEL++CGLG +DVNDW+ ++ K+ P+ +++WFWKAV D E+R R Sbjct: 612 HLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRAR 670 Query: 777 LLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS-PEKLPRAHTCFNRLDLPPYETFED 835 LLQFVTG+SRVP+ GF L G+ GP+LFTI Q + LP+AHTCFNR+D+PPYE++E Sbjct: 671 LLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEK 730 Query: 836 LREKLLMAVENAQGF 850 L EKLL A+E GF Sbjct: 731 LYEKLLTAIEETCGF 745 Score = 49.3 bits (116), Expect = 2e-05 Identities = 47/168 (27%), Positives = 67/168 (39%), Gaps = 33/168 (19%) Query: 11 LLRPRSHKSRVKGFLRLKMAYMPKNG-----GQDEENSDQRDDMEHGWEVVDSNDSASQH 65 LL ++ + G+ RL + + N GQ + RD + G +VVD + Sbjct: 99 LLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCS------ 152 Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL---------MDVSSESDNNI 116 L LP GWEE+ GR Y+NH RTTQW RP+ +S D N Sbjct: 153 --RLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENT 210 Query: 117 -----------RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWE 153 + + A RR RS+RH + D+PE +E Sbjct: 211 PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYE 258 Score = 47.8 bits (112), Expect = 4e-05 Identities = 20/33 (60%), Positives = 24/33 (72%) Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105 PLPPGWE + GR Y+V+HNNRTTQ+ P L Sbjct: 298 PLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330 Score = 33.9 bits (76), Expect = 0.66 Identities = 11/33 (33%), Positives = 19/33 (57%) Query: 71 PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 PP LP G+E++ G+ Y+++ + WH P Sbjct: 250 PPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP 282 >gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 isoform 1 [Homo sapiens] Length = 870 Score = 483 bits (1244), Expect = e-136 Identities = 286/711 (40%), Positives = 391/711 (54%), Gaps = 87/711 (12%) Query: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276 R S T E H PP + GR+R+ +G T + A +PG S + Sbjct: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASART-TPATGEQSPGARSRHRQPVKN 224 Query: 277 KGRTYYVNH--NNRTTTWTRP-----IMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSP 329 G + N N+ TT T P + + A S T + N P P P Sbjct: 225 SGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEP 284 Query: 330 TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLPPGWEMRIAP 388 + + + L A +P A+ + P Y T + LPPGWE R P Sbjct: 285 STSGTQQLPAAAQAP--DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDP 342 Query: 389 NGRPFFIDHNTKTTTWEDPRLKFP------------------------VHMRSKTSLNPN 424 GR +++DHNT+TTTW+ P ++ ++ S S + + Sbjct: 343 RGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD 402 Query: 425 DLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVP------------- 471 LGPLPPGWE+R +GR +Y++HN++ TQWEDPR Q I PA+P Sbjct: 403 PLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQG-MIQEPALPPGWEMKYTSEGVR 460 Query: 472 ------------------------------YSREFKQKYDYFRKKLKKPADIPNRFEMKL 501 Y R F+ KY FR A +P+ ++ + Sbjct: 461 YFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNA-LPSHVKISV 519 Query: 502 HRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGL 561 R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREWFFLLS E+ NP Y L Sbjct: 520 SRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCL 578 Query: 562 FEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGK 621 FEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK +D F PFYK ML K Sbjct: 579 FEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNK 637 Query: 622 QITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVT 679 + TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+ +LK G I VT Sbjct: 638 RPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVT 697 Query: 680 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 739 ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE ELEL++CG+ ++D+ Sbjct: 698 EENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDM 757 Query: 740 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 799 +DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT R+P+ GFAEL GSN Sbjct: 758 SDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSN 816 Query: 800 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 GPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+E +GF Sbjct: 817 GPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867 Score = 59.7 bits (143), Expect = 1e-08 Identities = 37/118 (31%), Positives = 52/118 (44%), Gaps = 16/118 (13%) Query: 47 DDMEHGWE----------VVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNR 96 D + GWE VD N + + PLPPGWE++ D GR YYV+HN R Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWER-----PLPPGWEKRTDPRGRFYYVDHNTR 354 Query: 97 TTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR-RHISEDLEPEPSEGGDVPEPWE 153 TT W RP+ V + ++ + A + F R + S + G +P WE Sbjct: 355 TTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWE 412 Score = 59.3 bits (142), Expect = 1e-08 Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 6/97 (6%) Query: 17 HKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWE--VVDSNDSASQHQEELPPPPL 74 H +R + R Y+ + + + M+H + + S+ +++ H P PL Sbjct: 351 HNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHD---PLGPL 407 Query: 75 PPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111 PPGWE++ DN GR YYVNHN RTTQW P + E Sbjct: 408 PPGWEKRQDN-GRVYYVNHNTRTTQWEDPRTQGMIQE 443 Score = 46.6 bits (109), Expect = 1e-04 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%) Query: 57 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103 + + ++ ++LP P LP GWE++ GR YYV+HN +TT W RP Sbjct: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331 Score = 42.4 bits (98), Expect = 0.002 Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 5/68 (7%) Query: 66 QEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAH 125 Q + P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A Sbjct: 438 QGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYD 492 Query: 126 RRFRSRRH 133 R FR + H Sbjct: 493 RSFRWKYH 500 >gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo sapiens] Length = 731 Score = 462 bits (1188), Expect = e-130 Identities = 244/528 (46%), Positives = 330/528 (62%), Gaps = 43/528 (8%) Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410 D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+ Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268 Query: 411 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQN-------- 462 R S+N ++LGPLPPGWE R + GR +++DHN++ TQ+ DPRL + Sbjct: 269 -----RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQL 323 Query: 463 ---------PAITG------PAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIF 507 P+ PA Y R+ QK R +L +++ R IF Sbjct: 324 KEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIF 383 Query: 508 EESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSAT 567 EESYR+IM + RP LK RL ++F E+GLDYGGVAREW +LL EM NPYYGLF+YS Sbjct: 384 EESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTD 442 Query: 568 DNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLND 627 + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG ++G F PFYK +LGK I L+D Sbjct: 443 NIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSD 501 Query: 628 MESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 686 +ESVD E + SL WILEND T LD FC++ FG+ Q +LKPNG + VT ENK+EY Sbjct: 502 LESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 561 Query: 687 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 746 + L + WRF+ ++ Q A +GF EL+P L+K FD+ ELEL++ GL +D+NDW+ ++ Sbjct: 562 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNT 621 Query: 747 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQL 803 K+ ++ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+L Sbjct: 622 RLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRL 680 Query: 804 FTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 FTI + + LP+AHTCFNR+D+PPYE++E L EKLL AVE GF Sbjct: 681 FTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 728 Score = 50.4 bits (119), Expect = 7e-06 Identities = 46/172 (26%), Positives = 69/172 (40%), Gaps = 55/172 (31%) Query: 210 QREPSSRLRSCSVTDAVAEQGHLP----PPSAPAGRARSSTVTGGEEPTPSVAYVHTTPG 265 QR + RLR+ V ++ + P P P G + +TV G V ++HT G Sbjct: 205 QRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQG------QVYFLHTQTG 258 Query: 266 -----------------------LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302 LP GWE R GR Y+V+HNNRTT +T P + Sbjct: 259 VSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL----- 313 Query: 303 GASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGA---KDSPVRRAVKD 351 +H++ Q + L P+ L P EG+ ++ P +R +D Sbjct: 314 ----------HHIMNHQCQ----LKEPSQPLPLPSEGSLEDEELPAQRYERD 351 Score = 47.4 bits (111), Expect = 6e-05 Identities = 20/33 (60%), Positives = 24/33 (72%) Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105 PLPPGWE + GR Y+V+HNNRTTQ+ P L Sbjct: 281 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313 Score = 30.4 bits (67), Expect = 7.3 Identities = 10/34 (29%), Positives = 19/34 (55%) Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105 P LP G+E++ G+ Y+++ + WH P + Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI 267 >gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo sapiens] Length = 757 Score = 456 bits (1173), Expect = e-128 Identities = 245/549 (44%), Positives = 331/549 (60%), Gaps = 59/549 (10%) Query: 351 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK 410 D + Q+PQ P+ P+ LP G+E R G+ +F+ T +TW DPR+ Sbjct: 216 DVRGSLQTPQNRPHGHQSPE-------LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268 Query: 411 FPV---------------------HMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHN 449 P R S+N ++LGPLPPGWE R + GR +++DHN Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328 Query: 450 SKITQWEDPRLQN-----------------PAITG------PAVPYSREFKQKYDYFRKK 486 ++ TQ+ DPRL + P+ PA Y R+ QK R + Sbjct: 329 NRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHE 388 Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546 L +++ R IFEESYR+IM + RP LK RL ++F E+GLDYGGVAREW Sbjct: 389 LSLQQPQAGHCRIEVSREEIFEESYRQIMKM-RPKDLKKRLMVKFRGEEGLDYGGVAREW 447 Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606 +LL EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+GR+ GLAVFHG + Sbjct: 448 LYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYI 506 Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTY 665 +G F PFYK +LGK I L+D+ESVD E + SL WILEND T LD FC++ FG+ Sbjct: 507 NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL 566 Query: 666 QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDEN 725 Q +LKPNG + VT ENK+EY+ L + WRF+ ++ Q A +GF EL+P L+K FD+ Sbjct: 567 QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK 626 Query: 726 ELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 785 ELEL++ GL +D+NDW+ ++ K+ ++ +++WFW+AV D E+R RLLQFVTG++ Sbjct: 627 ELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETFDEERRARLLQFVTGST 685 Query: 786 RVPMNGFAELYGSN---GPQLFTIEQW-GSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841 RVP+ GF L GS GP+LFTI + + LP+AHTCFNR+D+PPYE++E L EKLL Sbjct: 686 RVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLL 745 Query: 842 MAVENAQGF 850 AVE GF Sbjct: 746 TAVEETCGF 754 Score = 47.4 bits (111), Expect = 6e-05 Identities = 20/33 (60%), Positives = 24/33 (72%) Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105 PLPPGWE + GR Y+V+HNNRTTQ+ P L Sbjct: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339 Score = 46.6 bits (109), Expect = 1e-04 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 22/89 (24%) Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325 LP GWE R GR Y+V+HNNRTT +T P + +H++ Q + Sbjct: 308 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL---------------HHIMNHQCQ---- 348 Query: 326 LSSPTVTLSAPLEGA---KDSPVRRAVKD 351 L P+ L P EG+ ++ P +R +D Sbjct: 349 LKEPSQPLPLPSEGSLEDEELPAQRYERD 377 Score = 31.2 bits (69), Expect = 4.3 Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 8/88 (9%) Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131 P LP G+E++ G+ Y+++ + WH P + S A F + Sbjct: 234 PELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPG-----GDAAFLYEFLLQ 288 Query: 132 RHISE--DLEP-EPSEGGDVPEPWETIS 156 H SE DL E G +P WE S Sbjct: 289 GHTSEPRDLNSVNCDELGPLPPGWEVRS 316 >gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 isoform 2 [Homo sapiens] Length = 431 Score = 435 bits (1118), Expect = e-121 Identities = 216/426 (50%), Positives = 294/426 (69%), Gaps = 8/426 (1%) Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDPR--LQNPAITGPAVPYSREFKQKYDYFRKK 486 LPPGWE + +G +++DHN++ T ++DPR ++ G Y R F+ KY FR Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFL 66 Query: 487 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 546 A +P+ ++ + R +FE+S+++IM++K D L+ RL+I E+GLDYGG+AREW Sbjct: 67 CHSNA-LPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124 Query: 547 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 606 FFLLS E+ NP Y LFEY+ +NY LQINP S + N DHL+YF FIGR +A++HGK + Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183 Query: 607 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQT 664 D F PFYK ML K+ TL D+ES+D E+YNS+ WI EN+ E L+L F D E G+ Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243 Query: 665 YQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDE 724 +LK G I VT ENK EYI L+ WRF V++Q AFL+GF E+ P++ ++ FDE Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303 Query: 725 NELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGT 784 ELEL++CG+ ++D++DW++ +IY++ Y N IQWFW+ V MD EKRIRLLQFVTGT Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362 Query: 785 SRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844 R+P+ GFAEL GSNGPQ F I++ G LPR+HTCFNRLDLPPY+++E LREKLL A+ Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422 Query: 845 ENAQGF 850 E +GF Sbjct: 423 EETEGF 428 Score = 42.0 bits (97), Expect = 0.002 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 5/62 (8%) Query: 72 PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSR 131 P LPPGWE K + G Y+V+HN RTT + D ++ +Q + A R FR + Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTT-----TFKDPRPGFESGTKQGSPGAYDRSFRWK 59 Query: 132 RH 133 H Sbjct: 60 YH 61 Score = 40.8 bits (94), Expect = 0.005 Identities = 16/32 (50%), Positives = 22/32 (68%) Query: 264 PGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295 P LP GWE + ++G Y+V+HN RTTT+ P Sbjct: 5 PALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36 >gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Homo sapiens] Length = 1572 Score = 400 bits (1027), Expect = e-111 Identities = 237/599 (39%), Positives = 342/599 (57%), Gaps = 30/599 (5%) Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325 LP GWE + D +G+ ++V+HN+RTTT+ P + L + SA HL R RS Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPL-QSSRPTSALVHRQHLT-----RQRS 1040 Query: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ--PSPYNSPKPQHKVTQSFLPPGWE 383 S+ V + G P + +T+S PQ P YN K+ +FL Sbjct: 1041 HSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYND-----KIV-AFLRQPNI 1094 Query: 384 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRT 443 I +P +++ + R + + +S DL L +EE I Sbjct: 1095 FEILQERQPDLTRNHSLREKIQFIRTEGTPGLVRLSS--DADLVMLLSLFEEEIMSYVPP 1152 Query: 444 FYIDHNSKI---------TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKL--KKPAD 492 + H S + P Q PA PY R+F+ K F +KL K Sbjct: 1153 HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQ 1211 Query: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 552 P + ++ + R+++ E+++ +IM R D+ + +L++ F E+GLDY G +RE+FFL+S+ Sbjct: 1212 GPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSR 1271 Query: 553 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 612 E+FNPYYGLFEYSA D YT+QI+P S + H +F F GR+ GLA+ H LLD FF R Sbjct: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTR 1330 Query: 613 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKP 671 PFYK +L L+D+E +D E++ SL+W+ +ND + LDL F ++EE FGQ + +LKP Sbjct: 1331 PFYKALLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKP 1390 Query: 672 NGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLM 731 G+ I VT +NK+EYI+ +++WR V +Q + + GF E++ L+ +FD ELEL++ Sbjct: 1391 GGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVI 1450 Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791 G ++D++DWR ++ Y+ GY NH VI+WFW AV + E+R+RLLQFVTGTS +P G Sbjct: 1451 AGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEG 1510 Query: 792 FAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 FA L GSNGP+ F +E+WG LPRAHTCFNRLDLPPY +F L EKLL AVE F Sbjct: 1511 FASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569 Score = 72.4 bits (176), Expect = 2e-12 Identities = 89/355 (25%), Positives = 123/355 (34%), Gaps = 109/355 (30%) Query: 141 EPSEGGDVPEPWETISEEVNIAGDSLGLALPP-----PPASPGSRTSPQELSEELSRRLQ 195 EP+ G P E E V AG + +P P A + +EL E RR Sbjct: 687 EPTSSG----PAEGSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGS 742 Query: 196 ITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQ----------GHLPPPSAPAGRARSS 245 + + S Q E S+ + A A++ GH P S P+ R S Sbjct: 743 L--EGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVS 800 Query: 246 TVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP---------- 295 Y LP WE R D+ GR +YV+H NRTTTW RP Sbjct: 801 R------------YQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQ 848 Query: 296 ----IMQLAE---------------------DGASGSATNSNNHLIEPQIRR----PRSL 326 I Q+ + + G+ ++ H RR P S Sbjct: 849 RSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHST 908 Query: 327 SSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPY----NSPKPQHKVT-------- 374 S +TL + PV+ + PS Y N+ +H +T Sbjct: 909 SRSRITLL-----LQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 963 Query: 375 --------------------QSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL 409 Q LP GWEM+ G+ FF+DHN++TTT+ DPRL Sbjct: 964 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRL 1018 Score = 57.0 bits (136), Expect = 7e-08 Identities = 28/70 (40%), Positives = 42/70 (60%), Gaps = 4/70 (5%) Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSS--ESDNNIRQINQEAAHRRFRSR 131 LPP WE ++D+ GR +YV+H NRTT W RP+ + N+I+Q+ Q +RR++S Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQ--LNRRYQSI 866 Query: 132 RHISEDLEPE 141 R + PE Sbjct: 867 RRTMTNERPE 876 Score = 42.7 bits (99), Expect = 0.001 Identities = 16/30 (53%), Positives = 20/30 (66%) Query: 429 LPPGWEERIHLDGRTFYIDHNSKITQWEDP 458 LPP WE RI GR FY+DH ++ T W+ P Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838 Score = 42.0 bits (97), Expect = 0.002 Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 1/64 (1%) Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 133 LP GWE K D+ G+ ++V+HN+RTT + P L SS + + Q +R S Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVH-RQHLTRQRSHSAGE 1045 Query: 134 ISED 137 + ED Sbjct: 1046 VGED 1049 >gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] Length = 1606 Score = 378 bits (971), Expect = e-104 Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%) Query: 458 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515 P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M Sbjct: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268 Query: 516 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575 + R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+ Sbjct: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328 Query: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635 P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+ Sbjct: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387 Query: 636 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694 + SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR Sbjct: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447 Query: 695 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754 V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY Sbjct: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507 Query: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814 H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG Sbjct: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567 Query: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 LPRAHTCFNRLDLPPY ++ L EKLL AVE F Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603 Score = 65.9 bits (159), Expect = 2e-10 Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%) Query: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318 LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+ Sbjct: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890 Query: 319 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372 I RS S AP G DS + + +L + SP NS K Sbjct: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945 Query: 373 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417 +T P ++ N F + H T +T + LK F + + Sbjct: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003 Query: 418 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460 + +N + LP GWE + G++F++DHNS+ T + DPR+ Sbjct: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051 Score = 53.5 bits (127), Expect = 8e-07 Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%) Query: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130 PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++ Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887 Query: 131 -RRHISEDLEPEPS 143 +R I+ + E S Sbjct: 888 IQRTIATERSEEDS 901 Score = 52.4 bits (124), Expect = 2e-06 Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%) Query: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379 R P L SP S EG + P+ L N Q P P+ H T LP Sbjct: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832 Query: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407 P WE RI +GR F++DH +TTTW+ P Sbjct: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860 Score = 47.0 bits (110), Expect = 8e-05 Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%) Query: 374 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433 T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP Sbjct: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062 Query: 434 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492 R HL R++ S++++ L + P + ++ + P Sbjct: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114 Query: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551 ++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS Sbjct: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174 Score = 45.8 bits (107), Expect = 2e-04 Identities = 17/31 (54%), Positives = 21/31 (67%) Query: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458 PLPP WE RI GR FY+DH ++ T W+ P Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860 Score = 41.2 bits (95), Expect = 0.004 Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%) Query: 259 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318 + T LP GWE + D +G++++V+HN+R TT+ P + L +G N H Sbjct: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066 Query: 319 QIRRPRSLSS 328 ++R RS S+ Sbjct: 1067 HLQRLRSYSA 1076 Score = 37.4 bits (85), Expect = 0.060 Identities = 14/32 (43%), Positives = 22/32 (68%) Query: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105 LP GWE K D G++++V+HN+R T + P + Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051 >gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] Length = 4374 Score = 343 bits (880), Expect = 4e-94 Identities = 183/382 (47%), Positives = 253/382 (66%), Gaps = 9/382 (2%) Query: 475 EFKQKYDYFRKKLKKPADIPNRFEMKLH--RNNIFEESYRRIMSVKRPDVLKARLWIEFE 532 +F K YFR++L++ + + +M +H R+++FE+SYR + K P+ +K RL+I FE Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051 Query: 533 SEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFI 592 E+G D GG+ REW+ ++S+EMFNP Y LF S D T INP+S CN +HLSYF F+ Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110 Query: 593 GRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL-- 650 GR+ AV+ +LL+ +F R FYK +LGK + DMES D +Y L ++LEND + L Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170 Query: 651 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF 710 DL F + + FG DLKPNG+ I+VT ENK+EY+ LV Q R ++KQ+ AFLEGF Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230 Query: 711 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 770 E++P LI IF E ELELL+ GL +D++D + ++ Y + Y N IQWFW+A+ D Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289 Query: 771 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPP 829 R + LQFVTGTS+VP+ GFA L G NG Q F I + S ++LP AHTCFN+LDLP Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349 Query: 830 YETFEDLREKLLMAV-ENAQGF 850 YE+FE LR LL+A+ E ++GF Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371 >gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 [Homo sapiens] Length = 909 Score = 287 bits (735), Expect = 3e-77 Identities = 156/347 (44%), Positives = 223/347 (64%), Gaps = 7/347 (2%) Query: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560 +HR++IF S ++S LK + + F E+G+ G V REWF +LS E+ NP Y Sbjct: 557 VHRDSIFRSSCE-VVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYA 614 Query: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620 LF SA D T Q N NS + N DHL+YF F G++ GLA+ H +L++ +F R FYK +LG Sbjct: 615 LFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILG 672 Query: 621 KQITLNDMESVDSEYYNSLKWILENDPTEL--DLMFCIDEENFGQTYQVDLKPNGSEIMV 678 + D+ S+D EY +L+WIL+ND ++L +L F ++ + FG +V LKP G I+V Sbjct: 673 IPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILV 732 Query: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738 T NK EY+ LV + R +Q Q+NAFL+GF +P LI++FDE ELELL+ G+ ++D Sbjct: 733 TQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEID 792 Query: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798 V+DW +++ Y +GY PVIQWFW+ V + E+R+ LLQFVTG+SRVP GFA + G Sbjct: 793 VSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGG 852 Query: 799 NGPQLFTIEQWG-SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 844 +G Q FTI +P LP + TC N L LP Y + E L+++LL+A+ Sbjct: 853 SGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899 >gi|87116668 hypothetical protein LOC9870 [Homo sapiens] Length = 823 Score = 218 bits (554), Expect = 2e-56 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%) Query: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527 S F+ K ++F+++L K+P ++ +K+ R+ + E S + + D K Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491 Query: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587 + F+ E+ LD+GG REWF L+ K +F+ LF + +N L ++PN L Sbjct: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550 Query: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639 + F GR+ G ++ L + F R F ++G ++ E+ D E+Y S + Sbjct: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610 Query: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695 +IL ND +E++L+F EE + ++ Q+D L G++ VTN NK Y++L+ Q+R Sbjct: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668 Query: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754 ++V++++ FL+G EL+P +L+ IFDENELELLMCG GD+ V+D++ H++ G + Sbjct: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728 Query: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814 V++WFW V + E+ RLLQF TG+S++P GFA L S F I + Sbjct: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783 Query: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850 LP AHTCFN+L LP Y+++E++ L +A+ E +GF Sbjct: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820 >gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] Length = 872 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581 Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636 Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696 Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756 Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816 Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867 Query: 849 GF 850 GF Sbjct: 868 GF 869 >gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] Length = 852 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561 Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 562 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616 Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676 Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736 Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796 Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 797 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847 Query: 849 GF 850 GF Sbjct: 848 GF 849 >gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] Length = 875 Score = 204 bits (519), Expect = 3e-52 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%) Query: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556 +K+ R++I +++ R+ ++++ P LK +L++EFE E+G+D GGV++E+F L+ +E+FN Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584 Query: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616 P G+F Y + NP+S + FT IG V GLA+++ +LD F Y+ Sbjct: 585 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639 Query: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672 ++GK+ T D+ Y SLK +LE N ++ + F I + + FG DLK N Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699 Query: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731 G +I +TNEN++E+++L + V+KQ AF GF + +K +F E+ELL+ Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759 Query: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791 CG ++D + + Y GY + +I+ FW+ V E++ LQF TGT R P+ G Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819 Query: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848 +L NGP E+LP +HTCFN L LP Y + E L+E+LL A+ A+ Sbjct: 820 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870 Query: 849 GF 850 GF Sbjct: 871 GF 872 >gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] Length = 1083 Score = 187 bits (476), Expect = 3e-47 Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%) Query: 470 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522 +P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747 Query: 523 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577 LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805 Query: 578 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634 + + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865 Query: 635 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692 Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925 Query: 693 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751 +R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985 Query: 752 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811 Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040 Query: 812 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851 E+LP A TC N L LP + LR KLL A+E A GFE Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081 >gi|7657152 hect domain and RLD 3 [Homo sapiens] Length = 1050 Score = 184 bits (468), Expect = 2e-46 Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%) Query: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558 + + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP Sbjct: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762 Query: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618 YG+F Y N S C +H ++F IG GLA+++ ++D F YK + Sbjct: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817 Query: 619 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674 L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G Sbjct: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877 Query: 675 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734 + V +N++E++D + + F V + AF GF ++ ++++F +EL +M G Sbjct: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937 Query: 735 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794 + + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A Sbjct: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997 Query: 795 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF Sbjct: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047 >gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] Length = 776 Score = 184 bits (467), Expect = 3e-46 Identities = 120/369 (32%), Positives = 196/369 (53%), Gaps = 31/369 (8%) Query: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558 MK+ R ++ +S + KR D LK +L + F E GLD GG+ +EWF LL +++F+P Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476 Query: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618 YG+F Y D++ + S C D+ S F +G + GLAV++ LD F YK + Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531 Query: 619 LGKQI--------------TLNDMESVDSEYYNSLKWILENDPT---ELDLMFCIDEENF 661 L I T++D+ + E + L +L ++ + F + +E F Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591 Query: 662 GQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKI 721 G +LKP G +I VTN+N++EY+ L + + KQ AF GF + + + + Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651 Query: 722 FDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 781 E+E+L+CG D+D++ ++ + Y +GY I++FW VL + + +LL F Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710 Query: 782 TGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLL 841 TG+ RVP+ G A+L + S LP AHTCFN+L LPPY++ +DL++KL+ Sbjct: 711 TGSDRVPVGGMADL------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLI 764 Query: 842 MAVENAQGF 850 + + N++GF Sbjct: 765 IGISNSEGF 773 >gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] Length = 1049 Score = 177 bits (448), Expect = 5e-44 Identities = 106/354 (29%), Positives = 187/354 (52%), Gaps = 16/354 (4%) Query: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560 + R NI ++ + K D K L + F E +D GGV +E+F L+ +E+ +P YG Sbjct: 705 VRRENIVGDAMEVLRKTKNIDYKKP-LKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYG 763 Query: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620 +F Y D+ + + + + F IG + GLA+++ ++D F YK +L Sbjct: 764 MFRYYE-DSRLIWFSDKTF----EDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLK 818 Query: 621 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGSEI 676 K+ +L+D++ + + S++ +L+ +++ FC++ ENFG T +L NG++ Sbjct: 819 KKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADT 878 Query: 677 MVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGD 736 V +N++E++D + + F V +AF GF ++ ++ +F NEL+ ++ G + Sbjct: 879 AVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTN 938 Query: 737 VDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELY 796 D + +++ YK Y HP I+ FW+ + EK+ + L F+TG+ R+P+ G L Sbjct: 939 YDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL- 997 Query: 797 GSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850 +L G E LP +HTCFN LDLP Y E LR KL+ A+++ +GF Sbjct: 998 -----KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGF 1046 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.135 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 39,476,124 Number of Sequences: 37866 Number of extensions: 2184429 Number of successful extensions: 11323 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 103 Number of HSP's successfully gapped in prelim test: 231 Number of HSP's that attempted gapping in prelim test: 10037 Number of HSP's gapped (non-prelim): 1154 length of query: 854 length of database: 18,247,518 effective HSP length: 111 effective length of query: 743 effective length of database: 14,044,392 effective search space: 10434983256 effective search space used: 10434983256 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.