Guide to the Human Genome
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Search of human proteins with 22209009

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]
         (514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]             1033   0.0  
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]              1018   0.0  
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              997   0.0  
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   167   2e-41
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   166   6e-41
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   163   4e-40
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   163   4e-40
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ...   152   5e-37
gi|5031689 protein kinase D3 [Homo sapiens]                           149   5e-36
gi|115529463 protein kinase D1 [Homo sapiens]                         149   8e-36
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   145   1e-34
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...   145   1e-34
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]      144   1e-34
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]      144   1e-34
gi|120659787 protein kinase D2 isoform B [Homo sapiens]               144   3e-34
gi|120659785 protein kinase D2 isoform A [Homo sapiens]               144   3e-34
gi|120659782 protein kinase D2 isoform A [Homo sapiens]               144   3e-34
gi|19923468 protein kinase D2 isoform A [Homo sapiens]                144   3e-34
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                  139   5e-33
gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]        137   3e-32
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   135   1e-31
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   135   1e-31
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   135   1e-31
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   135   1e-31
gi|26667189 calcium/calmodulin-dependent protein kinase II delta...   135   1e-31
gi|26667180 calcium/calmodulin-dependent protein kinase II delta...   135   1e-31
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   133   4e-31
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   133   4e-31
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   133   4e-31
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   133   4e-31

>gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]
          Length = 514

 Score = 1033 bits (2671), Expect = 0.0
 Identities = 514/514 (100%), Positives = 514/514 (100%)

Query: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
           MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60

Query: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
           SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
Sbjct: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120

Query: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
           CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
Sbjct: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180

Query: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
           RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
Sbjct: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240

Query: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
           KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
Sbjct: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300

Query: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQITDFGHSKILGETSLMRTLCGTPT 360
           LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQITDFGHSKILGETSLMRTLCGTPT
Sbjct: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQITDFGHSKILGETSLMRTLCGTPT 360

Query: 361 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 420
           YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP
Sbjct: 361 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 420

Query: 421 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALP 480
           EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALP
Sbjct: 421 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALP 480

Query: 481 QVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 514
           QVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Sbjct: 481 QVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 514


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score = 1018 bits (2631), Expect = 0.0
 Identities = 514/543 (94%), Positives = 514/543 (94%), Gaps = 29/543 (5%)

Query: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
           MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60

Query: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
           SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
Sbjct: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120

Query: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
           CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
Sbjct: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180

Query: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
           RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
Sbjct: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240

Query: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
           KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
Sbjct: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300

Query: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ------------------------ 336
           LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ                        
Sbjct: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360

Query: 337 -----ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
                ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
Sbjct: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420

Query: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
           LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
Sbjct: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480

Query: 452 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 511
           LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
Sbjct: 481 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 540

Query: 512 AVL 514
           AVL
Sbjct: 541 AVL 543


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  997 bits (2577), Expect = 0.0
 Identities = 514/586 (87%), Positives = 514/586 (87%), Gaps = 72/586 (12%)

Query: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
           MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1   MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60

Query: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLE------------- 107
           SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLE             
Sbjct: 61  SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLEL 120

Query: 108 ------------------------------CVNDNYWFGRDKSCEYCFDEPLLKRTDKYR 137
                                         CVNDNYWFGRDKSCEYCFDEPLLKRTDKYR
Sbjct: 121 LLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYR 180

Query: 138 TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK 197
           TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK
Sbjct: 181 TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK 240

Query: 198 VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA 257
           VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA
Sbjct: 241 VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA 300

Query: 258 IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK 317
           IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK
Sbjct: 301 IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK 360

Query: 318 RLKEATCKLYFYQMLLAVQ-----------------------------ITDFGHSKILGE 348
           RLKEATCKLYFYQMLLAVQ                             ITDFGHSKILGE
Sbjct: 361 RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE 420

Query: 349 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK 408
           TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK
Sbjct: 421 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK 480

Query: 409 DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 468
           DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD
Sbjct: 481 DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 540

Query: 469 LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 514
           LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Sbjct: 541 LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 586


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  167 bits (423), Expect = 2e-41
 Identities = 101/289 (34%), Positives = 155/289 (53%), Gaps = 42/289 (14%)

Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
           +RD Y     LG+GA  EV LA +++T K VAIK I+K        +E     ++E EI 
Sbjct: 16  IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL---EGKEG----SMENEIA 68

Query: 276 ILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA 334
           +L K+ HP I+ + + +++  + Y++++L+ GGELFD++V      E       +Q+L A
Sbjct: 69  VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDA 128

Query: 335 VQ-----------------------------ITDFGHSKILGETSLMRTLCGTPTYLAPE 365
           V+                             I+DFG SK+    S++ T CGTP Y+APE
Sbjct: 129 VKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPE 188

Query: 366 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAE 425
           VL       Y++AVDCWS+GVI +I L GYPPF +      L +QI   +Y F    W +
Sbjct: 189 VLAQ---KPYSKAVDCWSIGVIAYILLCGYPPFYD-ENDAKLFEQILKAEYEFDSPYWDD 244

Query: 426 VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQ-DEDMKRKFQDLLSEE 473
           +S+ A D ++ L+  DP+ RFT E+AL+HPW+  D  + +     +SE+
Sbjct: 245 ISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQ 293


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  166 bits (419), Expect = 6e-41
 Identities = 108/284 (38%), Positives = 150/284 (52%), Gaps = 46/284 (16%)

Query: 207 DDQSVYPKA---LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE 263
           DD S + K    +R  +I  + LGSGA  EV L  +R T K  A+K I K      S   
Sbjct: 7   DDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK------SPAF 60

Query: 264 ADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEA 322
            D +L  E EI +LKK+ H  I+ +++ +++   YY+V++L+ GGELFD+++      E 
Sbjct: 61  RDSSL--ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK 118

Query: 323 TCKLYFYQMLLAVQ-----------------------------ITDFGHSKILGETSLMR 353
              L   Q+L AV+                             ITDFG SK + +  +M 
Sbjct: 119 DASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMS 177

Query: 354 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 413
           T CGTP Y+APEVL       Y++AVDCWS+GVI +I L GYPPF E  T+  L ++I  
Sbjct: 178 TACGTPGYVAPEVLAQ---KPYSKAVDCWSIGVITYILLCGYPPFYEE-TESKLFEKIKE 233

Query: 414 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           G Y F    W ++SE A D +  LL  DP  R+T E+AL HPW+
Sbjct: 234 GYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  163 bits (412), Expect = 4e-40
 Identities = 96/272 (35%), Positives = 146/272 (53%), Gaps = 41/272 (15%)

Query: 224 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 283
           +TLG+GA  EV LA E+ T K  A+K I K+       +E+    ++E EI +L+K+ H 
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL---KGKES----SIENEIAVLRKIKHE 79

Query: 284 CIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV------- 335
            I+ +++ +++ ++ Y+V++L+ GGELFD++V      E        Q+L AV       
Sbjct: 80  NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139

Query: 336 ----------------------QITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTA 373
                                  I+DFG SK+ G+  +M T CGTP Y+APEVL      
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ---K 196

Query: 374 GYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDL 433
            Y++AVDCWS+GVI +I L GYPPF +      L +QI   +Y F    W ++S+ A D 
Sbjct: 197 PYSKAVDCWSIGVIAYILLCGYPPFYDENDS-KLFEQILKAEYEFDSPYWDDISDSAKDF 255

Query: 434 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRK 465
           ++ L+  DP  R+T E+A RHPW+  +    K
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWIAGDTALNK 287


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  163 bits (412), Expect = 4e-40
 Identities = 96/272 (35%), Positives = 146/272 (53%), Gaps = 41/272 (15%)

Query: 224 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 283
           +TLG+GA  EV LA E+ T K  A+K I K+       +E+    ++E EI +L+K+ H 
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL---KGKES----SIENEIAVLRKIKHE 79

Query: 284 CIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV------- 335
            I+ +++ +++ ++ Y+V++L+ GGELFD++V      E        Q+L AV       
Sbjct: 80  NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139

Query: 336 ----------------------QITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTA 373
                                  I+DFG SK+ G+  +M T CGTP Y+APEVL      
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ---K 196

Query: 374 GYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDL 433
            Y++AVDCWS+GVI +I L GYPPF +      L +QI   +Y F    W ++S+ A D 
Sbjct: 197 PYSKAVDCWSIGVIAYILLCGYPPFYDENDS-KLFEQILKAEYEFDSPYWDDISDSAKDF 255

Query: 434 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRK 465
           ++ L+  DP  R+T E+A RHPW+  +    K
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWIAGDTALNK 287


>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
           sapiens]
          Length = 473

 Score =  152 bits (385), Expect = 5e-37
 Identities = 108/330 (32%), Positives = 156/330 (47%), Gaps = 51/330 (15%)

Query: 215 ALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEI 274
           AL D + +   LG GA   V    ++ T K  A+K++ K           D  + V TEI
Sbjct: 41  ALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT---------VDKKI-VRTEI 90

Query: 275 EILKKLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
            +L +L+HP IIK+K  F+   +  +VLEL+ GGELFD++V      E        Q+L 
Sbjct: 91  GVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILE 150

Query: 334 AV-----------------------------QITDFGHSKILGETSLMRTLCGTPTYLAP 364
           AV                             +I DFG SKI+    LM+T+CGTP Y AP
Sbjct: 151 AVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAP 210

Query: 365 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 424
           E+L       Y   VD WS+G+I +I L G+ PF + R    +  +I + +Y FI   W 
Sbjct: 211 EILRG---CAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267

Query: 425 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD--------EDMKRKFQDLLSEENES 476
           EVS  A DLV+KL+V+DPK R TT +AL+HPW+          +  ++K Q+  +     
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLK 327

Query: 477 TALPQVLAQPSTSRKRPREGEAEGAETTKR 506
            A+  V+A           G  + +    R
Sbjct: 328 AAVKAVVASSRLGSASSSHGSIQESHKASR 357


>gi|5031689 protein kinase D3 [Homo sapiens]
          Length = 890

 Score =  149 bits (377), Expect = 5e-36
 Identities = 96/286 (33%), Positives = 152/286 (53%), Gaps = 51/286 (17%)

Query: 206 VDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREAD 265
           VD  +VY      +    + LGSG  G V     RKT + VAIK+I K +F      +  
Sbjct: 568 VDISTVY------QIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQ-- 619

Query: 266 PALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNK--RLKEA 322
               +  E+ IL+ L+HP I+ ++  F+  E  ++V+E + G ++ + ++ ++  RL E 
Sbjct: 620 ----LRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPER 674

Query: 323 TCKLYFYQMLLA-----------------------------VQITDFGHSKILGETSLMR 353
             K    Q+L+A                             V++ DFG ++I+GE S  R
Sbjct: 675 ITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRR 734

Query: 354 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 413
           ++ GTP YLAPEVL S    GYNR++D WS+GVI+++ LSG  PF+E      + DQI +
Sbjct: 735 SVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGTFPFNEDE---DINDQIQN 788

Query: 414 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 459
             + + P  W E+S +A+DL+  LL V  + R++ +++L HPWLQD
Sbjct: 789 AAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834


>gi|115529463 protein kinase D1 [Homo sapiens]
          Length = 912

 Score =  149 bits (375), Expect = 8e-36
 Identities = 101/317 (31%), Positives = 165/317 (52%), Gaps = 57/317 (17%)

Query: 175 VGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEV 234
           VG G    L+ +  +++S+S  ++       VD  +VY      +    + LGSG  G V
Sbjct: 550 VGTGTN--LHRDISVSISVSNCQI----QENVDISTVY------QIFPDEVLGSGQFGIV 597

Query: 235 KLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA 294
                RKT + VAIKII K +F      +      +  E+ IL+ L+HP ++ ++  F+ 
Sbjct: 598 YGGKHRKTGRDVAIKIIDKLRFPTKQESQ------LRNEVAILQNLHHPGVVNLECMFET 651

Query: 295 -EDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLA----------------- 334
            E  ++V+E + G ++ + ++ ++  RL E   K    Q+L+A                 
Sbjct: 652 PERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPE 710

Query: 335 ------------VQITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCW 382
                       V++ DFG ++I+GE S  R++ GTP YLAPEVL +    GYNR++D W
Sbjct: 711 NVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRN---KGYNRSLDMW 767

Query: 383 SLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 442
           S+GVI+++ LSG  PF+E      + DQI +  + + P  W E+S +A+DL+  LL V  
Sbjct: 768 SVGVIIYVSLSGTFPFNEDE---DIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKM 824

Query: 443 KARFTTEEALRHPWLQD 459
           + R++ ++ L HPWLQD
Sbjct: 825 RKRYSVDKTLSHPWLQD 841


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  145 bits (365), Expect = 1e-34
 Identities = 96/271 (35%), Positives = 141/271 (52%), Gaps = 42/271 (15%)

Query: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
           Y + + LGSGA  EV LA ER +   VA+K I K+      A     AL VE EI +L++
Sbjct: 32  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKK------ALRGKEAL-VENEIAVLRR 84

Query: 280 LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV--- 335
           ++HP I+ +++  ++  + Y+ +EL+ GGELFD+++      E        Q+L AV   
Sbjct: 85  ISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYL 144

Query: 336 --------------------------QITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 369
                                      ++DFG SKI    +++ T CGTP Y+APE+L  
Sbjct: 145 HSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQ 203

Query: 370 VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK 429
                Y +AVD W+LGVI +I L GYPPF +  +   L  QI    Y F    W ++SE 
Sbjct: 204 ---KPYGKAVDVWALGVISYILLCGYPPFYD-ESDPELFSQILRASYEFDSPFWDDISES 259

Query: 430 ALDLVKKLLVVDPKARFTTEEALRHPWLQDE 460
           A D ++ LL  DP+ RFT ++ALRH W+  +
Sbjct: 260 AKDFIRHLLERDPQKRFTCQQALRHLWISGD 290


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score =  145 bits (365), Expect = 1e-34
 Identities = 96/271 (35%), Positives = 141/271 (52%), Gaps = 42/271 (15%)

Query: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
           Y + + LGSGA  EV LA ER +   VA+K I K+      A     AL VE EI +L++
Sbjct: 98  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKK------ALRGKEAL-VENEIAVLRR 150

Query: 280 LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAV--- 335
           ++HP I+ +++  ++  + Y+ +EL+ GGELFD+++      E        Q+L AV   
Sbjct: 151 ISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYL 210

Query: 336 --------------------------QITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 369
                                      ++DFG SKI    +++ T CGTP Y+APE+L  
Sbjct: 211 HSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQ 269

Query: 370 VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK 429
                Y +AVD W+LGVI +I L GYPPF +  +   L  QI    Y F    W ++SE 
Sbjct: 270 ---KPYGKAVDVWALGVISYILLCGYPPFYD-ESDPELFSQILRASYEFDSPFWDDISES 325

Query: 430 ALDLVKKLLVVDPKARFTTEEALRHPWLQDE 460
           A D ++ LL  DP+ RFT ++ALRH W+  +
Sbjct: 326 AKDFIRHLLERDPQKRFTCQQALRHLWISGD 356


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score =  144 bits (364), Expect = 1e-34
 Identities = 96/319 (30%), Positives = 155/319 (48%), Gaps = 53/319 (16%)

Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
           L ++Y + K +G G    VK   +R T K+ A+KII K K   G          +E E+ 
Sbjct: 389 LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK-CCGKEHL------IENEVS 441

Query: 276 ILKKLNHPCIIK-IKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM--- 331
           IL+++ HP II  ++    A + ++V+EL++GG+LFD +  + +  E       Y +   
Sbjct: 442 ILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANA 501

Query: 332 ------------------LLAVQITDFGHSKILGETSL-------MRTLCGTPTYLAPEV 366
                             LL  +  D   S  LG+  L       + T+CGTPTY+APE+
Sbjct: 502 LRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEI 561

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEVWAE 425
           +   G   Y   VD W+ GVI +I L G+PPF SE+  Q  L DQI +GK  F    W  
Sbjct: 562 IAETG---YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDN 618

Query: 426 VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE-------------DMKRKFQDLLSE 472
           +++ A +L+ ++L V+ +AR T  + L HPW+ D+              +K+ F + L +
Sbjct: 619 ITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPK 678

Query: 473 ENESTALPQVLAQPSTSRK 491
           +N +T    V+   +  ++
Sbjct: 679 QNSTTTGVSVIMNTALDKE 697


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score =  144 bits (364), Expect = 1e-34
 Identities = 96/319 (30%), Positives = 155/319 (48%), Gaps = 53/319 (16%)

Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
           L ++Y + K +G G    VK   +R T K+ A+KII K K   G          +E E+ 
Sbjct: 390 LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK-CCGKEHL------IENEVS 442

Query: 276 ILKKLNHPCIIK-IKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM--- 331
           IL+++ HP II  ++    A + ++V+EL++GG+LFD +  + +  E       Y +   
Sbjct: 443 ILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANA 502

Query: 332 ------------------LLAVQITDFGHSKILGETSL-------MRTLCGTPTYLAPEV 366
                             LL  +  D   S  LG+  L       + T+CGTPTY+APE+
Sbjct: 503 LRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEI 562

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEVWAE 425
           +   G   Y   VD W+ GVI +I L G+PPF SE+  Q  L DQI +GK  F    W  
Sbjct: 563 IAETG---YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDN 619

Query: 426 VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE-------------DMKRKFQDLLSE 472
           +++ A +L+ ++L V+ +AR T  + L HPW+ D+              +K+ F + L +
Sbjct: 620 ITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPK 679

Query: 473 ENESTALPQVLAQPSTSRK 491
           +N +T    V+   +  ++
Sbjct: 680 QNSTTTGVSVIMNTALDKE 698


>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
          Length = 721

 Score =  144 bits (362), Expect = 3e-34
 Identities = 93/308 (30%), Positives = 161/308 (52%), Gaps = 55/308 (17%)

Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
           +  + +++S+S +++       VD  +VY      +    + LGSG  G V     RKT 
Sbjct: 368 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 417

Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
           + VA+K+I K +F      +      +  E+ IL+ L HP I+ ++  F+  E  ++V+E
Sbjct: 418 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 471

Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLA-------------------------- 334
            + G ++ + ++ ++  RL E   K    Q+L+A                          
Sbjct: 472 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 530

Query: 335 ---VQITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
              V++ DFG ++I+GE S  R++ GTP YLAPEVL++    GYNR++D WS+GVI+++ 
Sbjct: 531 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 587

Query: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
           LSG  PF+E      + DQI +  + +    W+ +S  A+DL+  LL V  + R++ +++
Sbjct: 588 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 644

Query: 452 LRHPWLQD 459
           L HPWLQ+
Sbjct: 645 LSHPWLQE 652


>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score =  144 bits (362), Expect = 3e-34
 Identities = 93/308 (30%), Positives = 161/308 (52%), Gaps = 55/308 (17%)

Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
           +  + +++S+S +++       VD  +VY      +    + LGSG  G V     RKT 
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574

Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
           + VA+K+I K +F      +      +  E+ IL+ L HP I+ ++  F+  E  ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628

Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLA-------------------------- 334
            + G ++ + ++ ++  RL E   K    Q+L+A                          
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687

Query: 335 ---VQITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
              V++ DFG ++I+GE S  R++ GTP YLAPEVL++    GYNR++D WS+GVI+++ 
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744

Query: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
           LSG  PF+E      + DQI +  + +    W+ +S  A+DL+  LL V  + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801

Query: 452 LRHPWLQD 459
           L HPWLQ+
Sbjct: 802 LSHPWLQE 809


>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score =  144 bits (362), Expect = 3e-34
 Identities = 93/308 (30%), Positives = 161/308 (52%), Gaps = 55/308 (17%)

Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
           +  + +++S+S +++       VD  +VY      +    + LGSG  G V     RKT 
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574

Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
           + VA+K+I K +F      +      +  E+ IL+ L HP I+ ++  F+  E  ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628

Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLA-------------------------- 334
            + G ++ + ++ ++  RL E   K    Q+L+A                          
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687

Query: 335 ---VQITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
              V++ DFG ++I+GE S  R++ GTP YLAPEVL++    GYNR++D WS+GVI+++ 
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744

Query: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
           LSG  PF+E      + DQI +  + +    W+ +S  A+DL+  LL V  + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801

Query: 452 LRHPWLQD 459
           L HPWLQ+
Sbjct: 802 LSHPWLQE 809


>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score =  144 bits (362), Expect = 3e-34
 Identities = 93/308 (30%), Positives = 161/308 (52%), Gaps = 55/308 (17%)

Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
           +  + +++S+S +++       VD  +VY      +    + LGSG  G V     RKT 
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574

Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
           + VA+K+I K +F      +      +  E+ IL+ L HP I+ ++  F+  E  ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628

Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLA-------------------------- 334
            + G ++ + ++ ++  RL E   K    Q+L+A                          
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687

Query: 335 ---VQITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
              V++ DFG ++I+GE S  R++ GTP YLAPEVL++    GYNR++D WS+GVI+++ 
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744

Query: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
           LSG  PF+E      + DQI +  + +    W+ +S  A+DL+  LL V  + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801

Query: 452 LRHPWLQD 459
           L HPWLQ+
Sbjct: 802 LSHPWLQE 809


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score =  139 bits (351), Expect = 5e-33
 Identities = 88/280 (31%), Positives = 136/280 (48%), Gaps = 40/280 (14%)

Query: 213 PKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET 272
           P  + + Y + +T+G G    VK   ER T ++ A+KII K K      R  +    ++ 
Sbjct: 383 PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSK-----CRGKEHM--IQN 435

Query: 273 EIEILKKLNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM 331
           E+ IL+++ HP I+ +    D   + Y+V+EL++GG+LFD +    +  E       Y +
Sbjct: 436 EVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNL 495

Query: 332 ---------------------LLAVQITDFGHSKILGETSL-------MRTLCGTPTYLA 363
                                LL  +  D   S  LG+  L       + T+CGTPTY+A
Sbjct: 496 ASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVA 555

Query: 364 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEV 422
           PE++   G   Y   VD W+ GVI +I L G+PPF      Q  L DQI  G+ +F    
Sbjct: 556 PEIIAETG---YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPY 612

Query: 423 WAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDM 462
           W  VS+ A +L+  +L+VD   RF+  + L HPW+ D+ +
Sbjct: 613 WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL 652


>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
          Length = 387

 Score =  137 bits (344), Expect = 3e-32
 Identities = 90/275 (32%), Positives = 142/275 (51%), Gaps = 37/275 (13%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKR---KFAIGSAREADPALNVETEI 274
           + Y   + LG G    V+    + T ++ A+K+I       F+    RE   A     E+
Sbjct: 18  ENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREA--TLKEV 75

Query: 275 EILKKLN-HPCIIKIKNFFDAEDYY-IVLELMEGGELFDKVVGN------------KRLK 320
           +IL+K++ HP II++K+ ++   ++ +V +LM+ GELFD +               + L 
Sbjct: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135

Query: 321 EATCKLYFYQML--------------LAVQITDFGHSKILGETSLMRTLCGTPTYLAPEV 366
           E  C L+   ++              + +++TDFG S  L     +R +CGTP+YLAPE+
Sbjct: 136 EVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEI 195

Query: 367 L---VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVW 423
           +   ++    GY + VD WS GVI++  L+G PPF  HR Q+ +   I SG Y F    W
Sbjct: 196 IECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFW-HRKQMLMLRMIMSGNYQFGSPEW 254

Query: 424 AEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQ 458
            + S+   DLV + LVV P+ R+T EEAL HP+ Q
Sbjct: 255 DDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ 289


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
           isoform 3 [Homo sapiens]
          Length = 499

 Score =  135 bits (339), Expect = 1e-31
 Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           DEY + + LG GA   V+   +  T ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA       Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ G+        GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A DL+ K+L ++P  R T  EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  133 bits (334), Expect = 4e-31
 Identities = 87/271 (32%), Positives = 138/271 (50%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           D+Y + + LG GA   V+   ++ + ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA      +Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ GE        GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A +L+ ++L ++P  R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  133 bits (334), Expect = 4e-31
 Identities = 87/271 (32%), Positives = 138/271 (50%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           D+Y + + LG GA   V+   ++ + ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA      +Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ GE        GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A +L+ ++L ++P  R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  133 bits (334), Expect = 4e-31
 Identities = 87/271 (32%), Positives = 138/271 (50%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           D+Y + + LG GA   V+   ++ + ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA      +Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ GE        GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A +L+ ++L ++P  R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  133 bits (334), Expect = 4e-31
 Identities = 87/271 (32%), Positives = 138/271 (50%), Gaps = 41/271 (15%)

Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
           D+Y + + LG GA   V+   ++ + ++ A KII+ +K    SAR+      +E E  I 
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65

Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML---- 332
           + L HP I+++ +    E + Y+V +L+ GGELF+ +V  +   EA      +Q+L    
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

Query: 333 -------------------------LAVQITDFGHS-KILGETSLMRTLCGTPTYLAPEV 366
                                     AV++ DFG + ++ GE        GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185

Query: 367 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 426
           L       Y + VD W+ GVIL+I L GYPPF +   Q  L  QI +G Y+F    W  V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241

Query: 427 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 457
           + +A +L+ ++L ++P  R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,650,941
Number of Sequences: 37866
Number of extensions: 889330
Number of successful extensions: 7753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 454
Number of HSP's successfully gapped in prelim test: 345
Number of HSP's that attempted gapping in prelim test: 4749
Number of HSP's gapped (non-prelim): 1767
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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