Guide to the Human Genome
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Search of human proteins with 222080070

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222080070 pleckstrin homology domain-containing family G
member 6 isoform b [Homo sapiens]
         (758 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222080070 pleckstrin homology domain-containing family G memb...  1524   0.0  
gi|222080068 pleckstrin homology domain-containing family G memb...  1493   0.0  
gi|222080066 pleckstrin homology domain-containing family G memb...  1493   0.0  
gi|38373682 pleckstrin homology domain containing family G membe...   421   e-117
gi|111154084 pleckstrin homology domain containing family G memb...   421   e-117
gi|111154088 pleckstrin homology domain containing family G memb...   421   e-117
gi|111154080 pleckstrin homology domain containing family G memb...   421   e-117
gi|111154078 pleckstrin homology domain containing family G memb...   421   e-117
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...   103   8e-22
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...   103   8e-22
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...   103   8e-22
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    96   9e-20
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    96   9e-20
gi|51972240 pleckstrin homology domain containing, family G (wit...    93   1e-18
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...    86   2e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                80   9e-15
gi|71274148 pleckstrin homology domain containing, family G (wit...    80   9e-15
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    80   9e-15
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    80   9e-15
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    75   2e-13
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...    75   2e-13
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    75   2e-13
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    74   4e-13
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             74   4e-13
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    74   5e-13
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    74   7e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    74   7e-13
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor...    72   2e-12
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor...    72   2e-12
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor...    72   2e-12

>gi|222080070 pleckstrin homology domain-containing family G member
           6 isoform b [Homo sapiens]
          Length = 758

 Score = 1524 bits (3946), Expect = 0.0
 Identities = 758/758 (100%), Positives = 758/758 (100%)

Query: 1   MGCRLHAPGEKAAHDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLL 60
           MGCRLHAPGEKAAHDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLL
Sbjct: 1   MGCRLHAPGEKAAHDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLL 60

Query: 61  HSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGH 120
           HSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGH
Sbjct: 61  HSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGH 120

Query: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
           KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV
Sbjct: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180

Query: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMA 240
           PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMA
Sbjct: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMA 240

Query: 241 YAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARA 300
           YAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARA
Sbjct: 241 YAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARA 300

Query: 301 QEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST 360
           QEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST
Sbjct: 301 QEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST 360

Query: 361 LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVI 420
           LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVI
Sbjct: 361 LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVI 420

Query: 421 RPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQ 480
           RPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQ
Sbjct: 421 RPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQ 480

Query: 481 KLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTE 540
           KLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTE
Sbjct: 481 KLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTE 540

Query: 541 DTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLR 600
           DTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLR
Sbjct: 541 DTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLR 600

Query: 601 PHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRG 660
           PHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRG
Sbjct: 601 PHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRG 660

Query: 661 QLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIE 720
           QLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIE
Sbjct: 661 QLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIE 720

Query: 721 GAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
           GAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
Sbjct: 721 GAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758


>gi|222080068 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score = 1493 bits (3866), Expect = 0.0
 Identities = 744/744 (100%), Positives = 744/744 (100%)

Query: 15  DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 74
           DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL
Sbjct: 47  DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 106

Query: 75  EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 134
           EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL
Sbjct: 107 EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 166

Query: 135 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 194
           WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV
Sbjct: 167 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 226

Query: 195 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 254
           LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA
Sbjct: 227 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 286

Query: 255 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 314
           FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF
Sbjct: 287 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 346

Query: 315 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 374
           LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH
Sbjct: 347 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 406

Query: 375 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 434
           TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL
Sbjct: 407 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 466

Query: 435 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 494
           RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL
Sbjct: 467 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 526

Query: 495 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 554
           LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS
Sbjct: 527 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 586

Query: 555 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 614
           DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA
Sbjct: 587 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 646

Query: 615 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 674
           PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE
Sbjct: 647 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 706

Query: 675 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 734
           SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT
Sbjct: 707 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 766

Query: 735 RAQLQRMRGPHIIQLDTPLSASEV 758
           RAQLQRMRGPHIIQLDTPLSASEV
Sbjct: 767 RAQLQRMRGPHIIQLDTPLSASEV 790


>gi|222080066 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score = 1493 bits (3866), Expect = 0.0
 Identities = 744/744 (100%), Positives = 744/744 (100%)

Query: 15  DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 74
           DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL
Sbjct: 47  DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 106

Query: 75  EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 134
           EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL
Sbjct: 107 EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 166

Query: 135 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 194
           WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV
Sbjct: 167 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 226

Query: 195 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 254
           LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA
Sbjct: 227 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 286

Query: 255 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 314
           FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF
Sbjct: 287 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 346

Query: 315 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 374
           LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH
Sbjct: 347 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 406

Query: 375 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 434
           TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL
Sbjct: 407 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 466

Query: 435 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 494
           RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL
Sbjct: 467 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 526

Query: 495 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 554
           LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS
Sbjct: 527 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 586

Query: 555 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 614
           DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA
Sbjct: 587 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 646

Query: 615 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 674
           PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE
Sbjct: 647 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 706

Query: 675 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 734
           SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT
Sbjct: 707 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 766

Query: 735 RAQLQRMRGPHIIQLDTPLSASEV 758
           RAQLQRMRGPHIIQLDTPLSASEV
Sbjct: 767 RAQLQRMRGPHIIQLDTPLSASEV 790


>gi|38373682 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 249  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308

Query: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 309  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368

Query: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 369  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428

Query: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 429  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488

Query: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 489  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548

Query: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608

Query: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 609  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668

Query: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 669  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728

Query: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 729  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788

Query: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 789  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847

Query: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 848  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901

Query: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 902  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961

Query: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 962  SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006


>gi|111154084 pleckstrin homology domain containing family G member 5
            isoform b [Homo sapiens]
          Length = 1083

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 326  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 385

Query: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 386  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 445

Query: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 446  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 505

Query: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 506  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 565

Query: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 566  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 625

Query: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 626  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 685

Query: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 686  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 745

Query: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 746  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 805

Query: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 806  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 865

Query: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 866  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 924

Query: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 925  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 978

Query: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 979  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1038

Query: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 1039 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1083


>gi|111154088 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 249  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308

Query: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 309  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368

Query: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 369  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428

Query: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 429  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488

Query: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 489  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548

Query: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608

Query: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 609  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668

Query: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 669  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728

Query: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 729  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788

Query: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 789  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847

Query: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 848  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901

Query: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 902  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961

Query: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 962  SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006


>gi|111154080 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 249  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308

Query: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 309  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368

Query: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 369  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428

Query: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 429  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488

Query: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 489  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548

Query: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608

Query: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 609  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668

Query: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 669  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728

Query: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 729  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788

Query: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 789  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847

Query: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 848  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901

Query: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 902  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961

Query: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 962  SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006


>gi|111154078 pleckstrin homology domain containing family G member 5
            isoform c [Homo sapiens]
          Length = 1062

 Score =  421 bits (1083), Expect = e-117
 Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)

Query: 50   RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 106
            R  G   +G   S   +E+ K  +LE +LHT+S+FG+PRLP     D   WE     D  
Sbjct: 305  RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 364

Query: 107  -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 161
                 L +E SWREL+ GH+++++  CHQQEA+WELL TE  Y+RKL+++ +L    LLN
Sbjct: 365  EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 424

Query: 162  LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 221
            LQ  GLL EV AE LF N+P + + HR  W  V+ P LE+ R +   L P     GF  F
Sbjct: 425  LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 484

Query: 222  GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 281
            G  F PY++YC+  +  M Y R     N LF A++ W EKH +  R  L D+L KPHQR+
Sbjct: 485  GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 544

Query: 282  TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 341
            TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N  +RQ +E++ LAA   RI  Y
Sbjct: 545  TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 604

Query: 342  EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 401
            EV+E  SDEV+K L+ F  LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 605  EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 664

Query: 402  SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 461
            +D+LLVTK  +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF     A       
Sbjct: 665  TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 724

Query: 462  PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 504
                  W++    AQ  LQ+L+A+E    ++ L +L  ++D +                 
Sbjct: 725  QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 784

Query: 505  -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 556
                 SP+  R S+ S +    +++G T   + ++  P   ++    +  P        S
Sbjct: 785  TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 844

Query: 557  GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 612
               T    TPT    PL  +  R+   D    T S   L+D  + P P     P+AP+  
Sbjct: 845  LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 903

Query: 613  SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 669
              P  P         P +    PP   + +  AS     +++ L  A   G  PS+P+ +
Sbjct: 904  RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 957

Query: 670  DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 714
             S    A  +P   + G  +E GP +   G  S      L    A +     R+      
Sbjct: 958  LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1017

Query: 715  --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 758
              AS R++    P   ++ RKLT AQL R+R    + L++ L+ASEV
Sbjct: 1018 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1062


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score =  103 bits (256), Expect = 8e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 100 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 153
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 396 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 455

Query: 154 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 213
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 456 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 508

Query: 214 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 263
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 509 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 562

Query: 264 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 323
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 563 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 622

Query: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 623 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 668

Query: 384 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 411
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 669 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 696


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score =  103 bits (256), Expect = 8e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 100 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 153
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407

Query: 154 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 213
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460

Query: 214 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 263
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514

Query: 264 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 323
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574

Query: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620

Query: 384 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 411
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score =  103 bits (256), Expect = 8e-22
 Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)

Query: 100 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 153
           GE G SGL +E      WRELVP      + +    +QE + ELL TE  +VR L+++ D
Sbjct: 381 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 440

Query: 154 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 213
           L    +       L      + +F ++  LI  H  F D ++    +  + SG  ++ IG
Sbjct: 441 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 493

Query: 214 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 263
                       S F     RF      C R    +   + +Q  +P F AFVQ  E   
Sbjct: 494 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 547

Query: 264 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 323
           R  R  L D++    QR+TKYPLLL ++ + + E   +E +    E     L H+N  VR
Sbjct: 548 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 607

Query: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
             E+   L    +R+     L   SD +   L  F  LD+T           ++L+ EGP
Sbjct: 608 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 653

Query: 384 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 411
           +  +  ++  ++V++ L  D+LL+ + Q
Sbjct: 654 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 681


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)

Query: 31   SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 87
            S     LS   L +P P       +G   + SP L   T     H LE  L   S     
Sbjct: 693  SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 748

Query: 88   RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 147
              P  D ++W+   G D           +V G   ++Q    +QE + EL  TE  ++R 
Sbjct: 749  --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 792

Query: 148  LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 207
            L+++ DL+      +++  L+       LF N+P LI  H S W E +    EE     +
Sbjct: 793  LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 848

Query: 208  PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 267
              D +  +       +      Q+C      +   + +Q     F  F+Q  E H +  R
Sbjct: 849  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908

Query: 268  QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 326
              L DL+I   QR+TKYPLLL +++K +    ++ E L    +     L+++N  V+Q E
Sbjct: 909  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968

Query: 327  EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 386
             +  L    +R+     LE  S+ +      F +LDLT          TR+++ EGP+  
Sbjct: 969  NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 1014

Query: 387  KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 432
            +  ++  LD+++ L  D+L++ + Q +              +D  +   P L L  ++ +
Sbjct: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074

Query: 433  PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 475
             +  D  +F +I  ++        LV   S +D+  W+E  ++A
Sbjct: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1117


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)

Query: 31   SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 87
            S     LS   L +P P       +G   + SP L   T     H LE  L   S     
Sbjct: 653  SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 708

Query: 88   RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 147
              P  D ++W+   G D           +V G   ++Q    +QE + EL  TE  ++R 
Sbjct: 709  --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 752

Query: 148  LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 207
            L+++ DL+      +++  L+       LF N+P LI  H S W E +    EE     +
Sbjct: 753  LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 808

Query: 208  PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 267
              D +  +       +      Q+C      +   + +Q     F  F+Q  E H +  R
Sbjct: 809  ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868

Query: 268  QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 326
              L DL+I   QR+TKYPLLL +++K +    ++ E L    +     L+++N  V+Q E
Sbjct: 869  LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928

Query: 327  EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 386
             +  L    +R+     LE  S+ +      F +LDLT          TR+++ EGP+  
Sbjct: 929  NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 974

Query: 387  KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 432
            +  ++  LD+++ L  D+L++ + Q +              +D  +   P L L  ++ +
Sbjct: 975  RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034

Query: 433  PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 475
             +  D  +F +I  ++        LV   S +D+  W+E  ++A
Sbjct: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1077


>gi|51972240 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 7 [Homo sapiens]
          Length = 379

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 86/358 (24%), Positives = 156/358 (43%), Gaps = 45/358 (12%)

Query: 162 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRAS--GQPLDPIGLQSGFL 219
           LQ    L++V    LF N+  L +T   F + + G   +   AS     LD I + + + 
Sbjct: 10  LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69

Query: 220 TFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQ 279
             G     +  YCL     + Y    ++ +  F  +++WCE++++  R  + +LL+ P Q
Sbjct: 70  R-GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 127

Query: 280 RITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIG 339
           R+T+YPLLL  + KRS ++  +  + ++ E VE  +R + G+V+  +  +      + I 
Sbjct: 128 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEII- 186

Query: 340 PYEVLEPPSDEVEKNLRPFSTLDLTSPML--GVASEHTRQLLLEGPVRVKEGREGKLDVY 397
              V  P  D  ++   P     +    +   + S  +R LL EG + + E     LDVY
Sbjct: 187 ---VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTR-FLDVY 242

Query: 398 LFLFSDVLLVTKPQ--------------------------RKADKAKVIRPPLMLEKLVC 431
           LFLF+D LLVTK +                          ++     V+  P+ L++LV 
Sbjct: 243 LFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVV 302

Query: 432 QPLRD--------PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 481
           + +           N+FL+ H   ++   +A L+   +   +  W+ +   A +   K
Sbjct: 303 KSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 75/308 (24%), Positives = 137/308 (44%), Gaps = 30/308 (9%)

Query: 112  SWRELVPGHKEMSQELCH--QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM 169
            +W++LV     +  + C   +QE + EL  TE  +VR LK++  +       + R G+L 
Sbjct: 768  NWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQ---RVSREGILS 824

Query: 170  EVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG--LQSGFLTFGQRF-- 225
                  +F N+  +++ H    +++        R     +D IG  L + F   G+    
Sbjct: 825  PSELRKIFSNLEDILQLHIGLNEQMKAV---RKRNETSVIDQIGEDLLTWFSGPGEEKLK 881

Query: 226  HPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYP 285
            H    +C      +   + +Q+ +  F  FVQ  E +    R  L D++    QR+TKYP
Sbjct: 882  HAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYP 941

Query: 286  LLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRI--GPYEV 343
            LLL  + K +     +E +    +     L ++N  V++ E ++ L    +R+     ++
Sbjct: 942  LLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKL 1001

Query: 344  LEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSD 403
             E P+ E  +N      LDLT           R+++ EGP+  K  R+  +D+Y  L  D
Sbjct: 1002 SEYPNVEELRN------LDLTK----------RKMIHEGPLVWKVNRDKTIDLYTLLLED 1045

Query: 404  VLLVTKPQ 411
            +L++ + Q
Sbjct: 1046 ILVLLQKQ 1053


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 94/393 (23%), Positives = 169/393 (43%), Gaps = 61/393 (15%)

Query: 130  QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRS 189
            +Q  + EL+ TE  YV  L+++T++    L+  +   LL E     +F N   LI  +  
Sbjct: 1238 RQGYIHELIVTEENYVNDLQLVTEIFQKPLMESE---LLTEKEVAMIFVNWKELIMCNI- 1293

Query: 190  FWDEVLGPTLEETRASGQPLDPIGLQSGFLTFG-QRFHPYVQYCLRVKQTMAYAREQQET 248
               ++L       + SG+ + P+ +    L+       PY+++C R     A  +++ + 
Sbjct: 1294 ---KLLKALRVRKKMSGEKM-PVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDE 1349

Query: 249  NPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEA-LNAM 307
             P F  FV+      R     L   ++KP QR+T+YPL++  +L+ +PE     + L   
Sbjct: 1350 APDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHA 1409

Query: 308  IEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPM 367
            +E  E     +N  VR+ E  + L    + I  +   E  S+++  N    S  +   P 
Sbjct: 1410 LEKAEELCSQVNEGVREKENSDRL----EWIQAHVQCEGLSEQLVFN----SVTNCLGP- 1460

Query: 368  LGVASEHTRQLLLEGPV-RVKEGREGKLDVYLFLFSDVLL---VTKPQRKADKAKVIRP- 422
                    R+ L  G + + K  +E    +Y FLF+D LL   +TKP   +   KV  P 
Sbjct: 1461 --------RKFLHSGKLYKAKSNKE----LYGFLFNDFLLLTQITKPLGSSGTDKVFSPK 1508

Query: 423  ----------PLMLEKLVCQPLRDPN-SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEK 471
                      P+ L +++ +   DP+    + H++    +     +   S  +R  W++K
Sbjct: 1509 SNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISH---IDRVYTLRAESINERTAWVQK 1565

Query: 472  TQQAQAALQKLKAEEYVQ---QKRELLTLYRDQ 501
             + A        +E Y++   +KRE   L R Q
Sbjct: 1566 IKAA--------SELYIETEKKKREKAYLVRSQ 1590


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 153/674 (22%), Positives = 257/674 (38%), Gaps = 96/674 (14%)

Query: 124 SQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSL 183
           S +L +    + E+L TE  YV+ LK + +     + +  ++ L  E     LFGN+  +
Sbjct: 108 SPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTE-ERSALFGNIQDI 166

Query: 184 IRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAR 243
                 F  E+L   LE         DP+ +   F++  + FH Y QYC    +++A   
Sbjct: 167 YH----FNSELL-QDLENCEN-----DPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLT 216

Query: 244 EQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEA 303
           E      L   F +  E  K S    L   L+KP QRI KY LLLH +   +   +  E 
Sbjct: 217 ECMRNKILAKFFRERQETLKHS--LPLGSYLLKPVQRILKYHLLLHEI--ENHLDKDTEG 272

Query: 304 LNAMIEAVESFLR---HINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST 360
            + +++A+++  R   HIN   R+ E    L                  E++  L  +  
Sbjct: 273 YDVVLDAIDTMQRVAWHINDMKRKHEHAVRL-----------------QEIQSLLTNWKG 315

Query: 361 LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRK--ADKAK 418
            DLTS           +L+LEG  R++  +  +    LFLF  +LL+TK +      KA 
Sbjct: 316 PDLTS---------YGELVLEGTFRIQRAKNERT---LFLFDKLLLITKKRDDTFTYKAH 363

Query: 419 VIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQ----Q 474
           ++   LML +++    ++P SF + H   ++       V   S  D+  W+   +    +
Sbjct: 364 ILCGNLMLVEVI---PKEPLSFSVFH---YKNPKLQHTVQAKSQQDKRLWVLHLKRLILE 417

Query: 475 AQAALQKLKAEEYVQQKRELLTLYRDQDRESP--STRPSTPSLEGSQSSAEGRTPEFSTI 532
             AA    KA++ +    E+  ++      SP   T+    S EGS      R  E S+ 
Sbjct: 418 NHAAKIPAKAKQAI---LEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSR 474

Query: 533 IPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRL----T 588
              ++ T +T +D   V  +       +  P     +  P S      LR    L    T
Sbjct: 475 SHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWT 534

Query: 589 FSTLELRDIPLRPHP---PDPQAPQRRSAPELPEGILKGGSLPQED----PPTWSEEEDG 641
              +     P R  P    D +   +   P      L    L ++     P +W   +  
Sbjct: 535 DHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQME 594

Query: 642 ASERGNVVVETLHRARLRG----------------QLPSSPTHADSAGESPWESSGE--E 683
           ++E  +     + RA   G                +L +SP        +P+ SS E   
Sbjct: 595 STETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTI 654

Query: 684 EEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRG 743
           ++   ++    +  L+ M A+   RE  E   S+    +  P+ +     T+ Q    +G
Sbjct: 655 DDIDHVYDNISYEDLKLMVAK---REEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKG 711

Query: 744 PHIIQLDTPLSASE 757
               Q D  LS  E
Sbjct: 712 SLYAQTDGTLSGGE 725


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 100/435 (22%), Positives = 180/435 (41%), Gaps = 60/435 (13%)

Query: 86  MPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV 145
           +P++ P++    ++GE  DS  T +K+ ++         Q+L H  +   ELL TE  YV
Sbjct: 117 VPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQ---ELLHTEETYV 173

Query: 146 RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW-DEVLGPTLEETRA 204
           ++L ++  +    L +    G+  EV    +F N+ S+ R H  F   E+     EE   
Sbjct: 174 KRLHLLDQVFCTRLTD---AGIPPEVIMG-IFSNISSIHRFHGQFLLPELKTRITEEWDT 229

Query: 205 SGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKR 264
           + +  D +   + FL        Y +Y     + +       + +PLF   V   +K + 
Sbjct: 230 NPRLGDILQKLAPFLKM------YGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 265 SGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQEALNAMIEAVESFLRHINGQVR 323
            G   L   +++P QR+ +Y LLL   LKR P +A  ++     +E + +   H N  +R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
           + E+   L    +++G  E +  P++E                           L+ EG 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANE---------------------------LIKEGQ 376

Query: 384 VRVKEGREG-KLDVYLFLFSDVLLVTKPQRKADKAKV-IRPPLMLEKLVCQPLRDPNSFL 441
           ++    + G   D +LFLF+ ++L   P+ +    K  +R  + +  L  Q +  PN+  
Sbjct: 377 IQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNT-- 434

Query: 442 LIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYR-- 499
             H         +L +   +  ++ +W+   Q  QA ++K K      Q  E    +   
Sbjct: 435 -AHTFIITGRKRSLELQTRTEEEKKEWI---QIIQATIEKHK------QNSETFKAFGGA 484

Query: 500 -DQDRESPSTRPSTP 513
             QD E PS  P  P
Sbjct: 485 FSQD-EDPSLSPDMP 498


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 100/435 (22%), Positives = 180/435 (41%), Gaps = 60/435 (13%)

Query: 86  MPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV 145
           +P++ P++    ++GE  DS  T +K+ ++         Q+L H  +   ELL TE  YV
Sbjct: 117 VPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQ---ELLHTEETYV 173

Query: 146 RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW-DEVLGPTLEETRA 204
           ++L ++  +    L +    G+  EV    +F N+ S+ R H  F   E+     EE   
Sbjct: 174 KRLHLLDQVFCTRLTD---AGIPPEVIMG-IFSNISSIHRFHGQFLLPELKTRITEEWDT 229

Query: 205 SGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKR 264
           + +  D +   + FL        Y +Y     + +       + +PLF   V   +K + 
Sbjct: 230 NPRLGDILQKLAPFLKM------YGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 265 SGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQEALNAMIEAVESFLRHINGQVR 323
            G   L   +++P QR+ +Y LLL   LKR P +A  ++     +E + +   H N  +R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 324 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 383
           + E+   L    +++G  E +  P++E                           L+ EG 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANE---------------------------LIKEGQ 376

Query: 384 VRVKEGREG-KLDVYLFLFSDVLLVTKPQRKADKAKV-IRPPLMLEKLVCQPLRDPNSFL 441
           ++    + G   D +LFLF+ ++L   P+ +    K  +R  + +  L  Q +  PN+  
Sbjct: 377 IQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNT-- 434

Query: 442 LIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYR-- 499
             H         +L +   +  ++ +W+   Q  QA ++K K      Q  E    +   
Sbjct: 435 -AHTFIITGRKRSLELQTRTEEEKKEWI---QIIQATIEKHK------QNSETFKAFGGA 484

Query: 500 -DQDRESPSTRPSTP 513
             QD E PS  P  P
Sbjct: 485 FSQD-EDPSLSPDMP 498


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)

Query: 113 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 170
           W E+  +   + ++     +QEA++E+   E   +  LK+        +L L    ++ E
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212

Query: 171 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 230
                +FG++ S I  H    +++L    E T+  G  ++ IG     +++  R + Y  
Sbjct: 213 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 265

Query: 231 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 290
           YC       A   +Q++ +P    F+Q C +   S +  L   L  P  R+ KYPLLL  
Sbjct: 266 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324

Query: 291 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 349
           +LK +P+     + L   I  ++  L  IN  +++GE +         I   E L    D
Sbjct: 325 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 373

Query: 350 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409
           E +++ R                E ++ LL  G +R K G +    +Y+FLF D+L++T+
Sbjct: 374 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 414

Query: 410 PQRKADK--AKVIRPPLMLEKLVCQPLRD 436
           P  + ++   +V R P+ +++LV + L+D
Sbjct: 415 PVTRNERHSYQVYRQPIPVQELVLEDLQD 443


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
           [Homo sapiens]
          Length = 542

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)

Query: 113 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 170
           W E+  +   + ++     +QEA++E+   E   +  LK+        +L L    ++ E
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 158

Query: 171 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 230
                +FG++ S I  H    +++L    E T+  G  ++ IG     +++  R + Y  
Sbjct: 159 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 211

Query: 231 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 290
           YC       A   +Q++ +P    F+Q C +   S +  L   L  P  R+ KYPLLL  
Sbjct: 212 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270

Query: 291 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 349
           +LK +P+     + L   I  ++  L  IN  +++GE +         I   E L    D
Sbjct: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 319

Query: 350 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409
           E +++ R                E ++ LL  G +R K G +    +Y+FLF D+L++T+
Sbjct: 320 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 360

Query: 410 PQRKADK--AKVIRPPLMLEKLVCQPLRD 436
           P  + ++   +V R P+ +++LV + L+D
Sbjct: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQD 389


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 89/358 (24%), Positives = 146/358 (40%), Gaps = 53/358 (14%)

Query: 134 LWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDE 193
           L E+  TE  Y R L+   D+    +  L+ V  L       +F N+  LI+ H SF   
Sbjct: 198 LLEIQETEAKYYRTLE---DIEKNYMSPLRLV--LSPADMAAVFINLEDLIKVHHSF--- 249

Query: 194 VLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFH 253
            L          G  L  +     FL F +R   Y +YC  ++       +   +   F 
Sbjct: 250 -LRAIDVSVMVGGSTLAKV-----FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFR 303

Query: 254 AFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVES 313
             V+ C    + G+  L DLL+ P QR+ KY LLL  +L  S E   ++ L   +EA++ 
Sbjct: 304 QKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQD 363

Query: 314 FLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASE 373
              +IN +V++ +E                           LR  S    +   L V  E
Sbjct: 364 LAMYIN-EVKRDKE--------------------------TLRKISEFQSSIENLQVKLE 396

Query: 374 HTRQLLLEGPVRVKE-GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQ 432
              +  ++G ++V+      K D YLFLF  V++V K +  + + K I   L+  K+   
Sbjct: 397 EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEI-IELLFHKMTDD 455

Query: 433 PLRDPN------SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKA 484
           P+ + +       F LIHL   Q         C +   + +W+E+ + A + ++  KA
Sbjct: 456 PMNNKDVKKWSYGFYLIHLQGKQ----GFQFFCKTEDMKRKWMEQFEMAMSNIKPDKA 509


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 96/368 (26%), Positives = 151/368 (41%), Gaps = 52/368 (14%)

Query: 130 QQEALW----ELLTTELIYVRKLKIMTDLLAAGLLNLQRVG--LLMEVSAETLFGNVPSL 183
           +Q A W    EL  TE  YV  L  +  L    L    + G  +L     +T+FG++P +
Sbjct: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477

Query: 184 IRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQ----RFHPYVQYCLRVKQTM 239
              H    D+     LE+   +      IG    FL + +     + P+V +    K+T+
Sbjct: 478 FDVHTKIKDD-----LEDLIVNWDESKSIG--DIFLKYSKDLVKTYPPFVNFFEMSKETI 530

Query: 240 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEAR 299
               +Q+   P FHAF++  +     GRQ L +LLI+P QR+    LLL+ + K + +  
Sbjct: 531 IKCEKQK---PRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADEN 587

Query: 300 AQEA-LNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 358
             ++ L   I +++  + HIN   R+ E Q+ +         YEV   P++ +  +    
Sbjct: 588 PDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVV-----YEVDGCPANLLSSHRSLV 642

Query: 359 STLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA---- 414
             ++  S             L E P    E       V LFLF+D L + + + K     
Sbjct: 643 QRVETIS-------------LGEHPCDRGE------QVTLFLFNDCLEIARKRHKVIGTF 683

Query: 415 -DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQ 473
                  RPP  L+ +   PL      L I  TE    + ALLV    PT++A  L   Q
Sbjct: 684 RSPHGQTRPPASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVR--PPTEQANVLLSFQ 741

Query: 474 QAQAALQK 481
                L K
Sbjct: 742 MTSDELPK 749


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 54/385 (14%)

Query: 122 EMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVP 181
           ++S E   +QEA++E+LT+E  Y   L I+ +     L + +    + ++    LF N+ 
Sbjct: 277 QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQMEHHHLFSNIL 333

Query: 182 SLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLT--FGQRFHPYVQYCLRVKQTM 239
            ++   + F++++      E R   Q L  +   S  L     + FHPY+ YC       
Sbjct: 334 DVLGASQRFFEDL------EQRHKAQVL--VEDISDILEEHAEKHFHPYIAYCSNEVYQQ 385

Query: 240 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAV-LKRSPEA 298
              ++   +N  F   ++  E+    G   +   LI P QR+T+ PLL+  + LK    +
Sbjct: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445

Query: 299 RAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 358
              +A +  ++A+   +R  N    + E  E +     ++   +V   P     + L   
Sbjct: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKR 505

Query: 359 STLDL---TSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD 415
             L L   T     +AS  T                     YLFLF+DVL+VTK  +K++
Sbjct: 506 GELFLVEETGLFRKIASRPT--------------------CYLFLFNDVLVVTK--KKSE 543

Query: 416 KAKVIRPPLMLEKLVCQPLRD---------------PNSFLLIHLTEFQCVSSALLVHCP 460
           ++ +++    +  +  + +                 P+ F +  L   +     LL+   
Sbjct: 544 ESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSD 603

Query: 461 SPTDRAQWLEKTQQAQAALQKLKAE 485
           S +DRA+W+     ++   Q L ++
Sbjct: 604 SASDRARWIVALTHSERQWQGLSSK 628


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 27/288 (9%)

Query: 123 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 182
           +SQE   +QEA++E++++E  Y+  L+I+  +      + +    + +     LF N+  
Sbjct: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKN---SKELSDTMTKTERHHLFSNITD 489

Query: 183 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA 242
           +    + F+ E     LE    +   +D I       T    F PYV+YC          
Sbjct: 490 VCEASKKFFIE-----LEARHQNNIFIDDISDIVEKHT-ASTFDPYVKYCTNEVYQQRTL 543

Query: 243 REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQ 301
           ++   TNP F   +   E H+      +   LI P QR+T+ PLL+  + +++P ++   
Sbjct: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603

Query: 302 EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTL 361
           E     ++ V   +R  N   R+ E  E +         Y +    + ++E  ++PF   
Sbjct: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMM---------YTI----NSQLEFKIKPF--- 647

Query: 362 DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409
            L S    +         +E  V     R  K  VY FLF+DVL++TK
Sbjct: 648 PLVSSSRWLVKRGELTAYVEDTVLFSR-RTSKQQVYFFLFNDVLIITK 694


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 85/363 (23%), Positives = 152/363 (41%), Gaps = 54/363 (14%)

Query: 130 QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM-EVSAETLFGNVPSLIRTHR 188
           +++ + ELL TE  YV +L ++  +    LL   R      E     +F N+ S+ + H 
Sbjct: 103 EKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHS 162

Query: 189 SFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQET 248
            F+   L   L++  A+ +  D I   + FL        Y +Y    ++         + 
Sbjct: 163 QFFLPELQRRLDDWTANPRIGDVIQKLAPFLKM------YSEYVKNFERAAELLATWTDK 216

Query: 249 NPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-----EARAQEA 303
           +PLF   +   +  + SG   L   +++P QRI +Y LLL   +++ P     +A AQ+A
Sbjct: 217 SPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKA 276

Query: 304 LNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDL 363
           L+ +  A +    H N  + + E  + L    QR+G  + +  PS+              
Sbjct: 277 LDMIFSAAQ----HSNAAITEMERLQDLWEVYQRLGLEDDIVDPSN-------------- 318

Query: 364 TSPMLGVASEHTRQLLLEGPV-RVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKV-IR 421
                         LL EGPV ++   R   ++ YLFLF+++LL   P+     A+  +R
Sbjct: 319 -------------TLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVR 365

Query: 422 PPLMLEKLVCQPLRD---PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAA 478
             + +  +  + L D   P+SFL+            L +   S  +   W++  Q A   
Sbjct: 366 TRIDVAGMKVRELMDAEFPHSFLV------SGKQRTLELQARSQEEMISWMQAFQAAIDQ 419

Query: 479 LQK 481
           ++K
Sbjct: 420 IEK 422


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 89/363 (24%), Positives = 146/363 (40%), Gaps = 58/363 (15%)

Query: 134 LWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDE 193
           L E+  TE  Y R L+   D+    +  L+ V  L       +F N+  LI+ H SF   
Sbjct: 203 LLEIQETEAKYYRTLE---DIEKNYMSPLRLV--LSPADMAAVFINLEDLIKVHHSF--- 254

Query: 194 VLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFH 253
            L          G  L  +     FL F +R   Y +YC  ++       +   +   F 
Sbjct: 255 -LRAIDVSVMVGGSTLAKV-----FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFR 308

Query: 254 AFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVES 313
             V+ C    + G+  L DLL+ P QR+ KY LLL  +L  S E   ++ L   +EA++ 
Sbjct: 309 QKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQD 368

Query: 314 FLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASE 373
              +IN +V++ +E                           LR  S    +   L V  E
Sbjct: 369 LAMYIN-EVKRDKE--------------------------TLRKISEFQSSIENLQVKLE 401

Query: 374 HTRQLLLEGPVRVKE-GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQ 432
              +  ++G ++V+      K D YLFLF  V++V K +  + + K I   L+  K+   
Sbjct: 402 EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEI-IELLFHKMTDD 460

Query: 433 PLRDPN-----------SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 481
           P+ + +            F LIHL   Q         C +   + +W+E+ + A + ++ 
Sbjct: 461 PMNNKDVKKSHGKMWSYGFYLIHLQGKQ----GFQFFCKTEDMKRKWMEQFEMAMSNIKP 516

Query: 482 LKA 484
            KA
Sbjct: 517 DKA 519


>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
           [Homo sapiens]
          Length = 985

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)

Query: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
           ++  +E+  QQ+ ++EL+ TEL +VR LKIMT L   G+L       L     + LF  V
Sbjct: 226 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 282

Query: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 232
             L   H  F  ++L     +    G   + +  + G L   Q   P        Y ++C
Sbjct: 283 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 341

Query: 233 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 289
            R  + +   +E    +  F  F++   +    KR G Q  C LL+   QRITKYPLL+ 
Sbjct: 342 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 398

Query: 290 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 347
            +L+ S   E   Q+   A+       ++ +   V +G  Q    A  Q I  Y  ++P 
Sbjct: 399 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 451

Query: 348 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 405
           +        PF   +L            R+L+ +G +  K       DV + L +DVL  
Sbjct: 452 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 501

Query: 406 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 457
           L  K Q+      DK  V+     L+ L+ + + +    + +       +S+A      V
Sbjct: 502 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 550

Query: 458 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 499
           H  S  DR+ W+   QQ+                 +A L+++K E  +QQK R L+ L R
Sbjct: 551 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 608

Query: 500 DQ 501
           ++
Sbjct: 609 EK 610


>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
           [Homo sapiens]
          Length = 986

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)

Query: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
           ++  +E+  QQ+ ++EL+ TEL +VR LKIMT L   G+L       L     + LF  V
Sbjct: 227 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 283

Query: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 232
             L   H  F  ++L     +    G   + +  + G L   Q   P        Y ++C
Sbjct: 284 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 342

Query: 233 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 289
            R  + +   +E    +  F  F++   +    KR G Q  C LL+   QRITKYPLL+ 
Sbjct: 343 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 399

Query: 290 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 347
            +L+ S   E   Q+   A+       ++ +   V +G  Q    A  Q I  Y  ++P 
Sbjct: 400 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 452

Query: 348 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 405
           +        PF   +L            R+L+ +G +  K       DV + L +DVL  
Sbjct: 453 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 502

Query: 406 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 457
           L  K Q+      DK  V+     L+ L+ + + +    + +       +S+A      V
Sbjct: 503 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 551

Query: 458 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 499
           H  S  DR+ W+   QQ+                 +A L+++K E  +QQK R L+ L R
Sbjct: 552 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 609

Query: 500 DQ 501
           ++
Sbjct: 610 EK 611


>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
           [Homo sapiens]
          Length = 958

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)

Query: 121 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 180
           ++  +E+  QQ+ ++EL+ TEL +VR LKIMT L   G+L       L     + LF  V
Sbjct: 199 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 255

Query: 181 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 232
             L   H  F  ++L     +    G   + +  + G L   Q   P        Y ++C
Sbjct: 256 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 314

Query: 233 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 289
            R  + +   +E    +  F  F++   +    KR G Q  C LL+   QRITKYPLL+ 
Sbjct: 315 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 371

Query: 290 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 347
            +L+ S   E   Q+   A+       ++ +   V +G  Q    A  Q I  Y  ++P 
Sbjct: 372 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 424

Query: 348 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 405
           +        PF   +L            R+L+ +G +  K       DV + L +DVL  
Sbjct: 425 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 474

Query: 406 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 457
           L  K Q+      DK  V+     L+ L+ + + +    + +       +S+A      V
Sbjct: 475 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 523

Query: 458 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 499
           H  S  DR+ W+   QQ+                 +A L+++K E  +QQK R L+ L R
Sbjct: 524 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 581

Query: 500 DQ 501
           ++
Sbjct: 582 EK 583


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,692,728
Number of Sequences: 37866
Number of extensions: 1800956
Number of successful extensions: 8385
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 206
Number of HSP's that attempted gapping in prelim test: 7876
Number of HSP's gapped (non-prelim): 634
length of query: 758
length of database: 18,247,518
effective HSP length: 110
effective length of query: 648
effective length of database: 14,082,258
effective search space: 9125303184
effective search space used: 9125303184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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