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Search of human proteins with 222080068
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222080068 pleckstrin homology domain-containing family G
member 6 isoform a [Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222080068 pleckstrin homology domain-containing family G memb... 1588 0.0
gi|222080066 pleckstrin homology domain-containing family G memb... 1588 0.0
gi|222080070 pleckstrin homology domain-containing family G memb... 1493 0.0
gi|38373682 pleckstrin homology domain containing family G membe... 421 e-117
gi|111154084 pleckstrin homology domain containing family G memb... 421 e-117
gi|111154088 pleckstrin homology domain containing family G memb... 421 e-117
gi|111154080 pleckstrin homology domain containing family G memb... 421 e-117
gi|111154078 pleckstrin homology domain containing family G memb... 421 e-117
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 103 8e-22
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 103 8e-22
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 103 8e-22
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 96 1e-19
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 96 1e-19
gi|51972240 pleckstrin homology domain containing, family G (wit... 93 1e-18
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 86 2e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 80 1e-14
gi|71274148 pleckstrin homology domain containing, family G (wit... 80 1e-14
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 80 1e-14
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 80 1e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 75 2e-13
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 75 2e-13
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 75 2e-13
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 74 4e-13
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 74 4e-13
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 74 5e-13
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 74 7e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 74 7e-13
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 72 3e-12
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 72 3e-12
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 72 3e-12
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 1588 bits (4111), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA 60
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
Sbjct: 1 MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA 60
Query: 61 RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR 120
RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
Sbjct: 61 RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR 120
Query: 121 LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL 180
LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
Sbjct: 121 LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL 180
Query: 181 KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP 240
KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
Sbjct: 181 KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP 240
Query: 241 LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ 300
LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
Sbjct: 241 LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ 300
Query: 301 MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ 360
MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
Sbjct: 301 MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ 360
Query: 361 ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE 420
ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
Sbjct: 361 ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE 420
Query: 421 GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF 480
GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF
Sbjct: 421 GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF 480
Query: 481 QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST 540
QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
Sbjct: 481 QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST 540
Query: 541 RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG 600
RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
Sbjct: 541 RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG 600
Query: 601 SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP 660
SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
Sbjct: 601 SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP 660
Query: 661 QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP 720
QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
Sbjct: 661 QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP 720
Query: 721 LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ 780
LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
Sbjct: 721 LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ 780
Query: 781 LDTPLSASEV 790
LDTPLSASEV
Sbjct: 781 LDTPLSASEV 790
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 1588 bits (4111), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA 60
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
Sbjct: 1 MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA 60
Query: 61 RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR 120
RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
Sbjct: 61 RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR 120
Query: 121 LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL 180
LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
Sbjct: 121 LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL 180
Query: 181 KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP 240
KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
Sbjct: 181 KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP 240
Query: 241 LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ 300
LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
Sbjct: 241 LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ 300
Query: 301 MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ 360
MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
Sbjct: 301 MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ 360
Query: 361 ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE 420
ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
Sbjct: 361 ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE 420
Query: 421 GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF 480
GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF
Sbjct: 421 GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF 480
Query: 481 QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST 540
QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
Sbjct: 481 QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST 540
Query: 541 RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG 600
RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
Sbjct: 541 RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG 600
Query: 601 SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP 660
SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
Sbjct: 601 SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP 660
Query: 661 QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP 720
QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
Sbjct: 661 QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP 720
Query: 721 LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ 780
LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
Sbjct: 721 LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ 780
Query: 781 LDTPLSASEV 790
LDTPLSASEV
Sbjct: 781 LDTPLSASEV 790
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 1493 bits (3866), Expect = 0.0
Identities = 744/744 (100%), Positives = 744/744 (100%)
Query: 47 DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 106
DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL
Sbjct: 15 DPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHEL 74
Query: 107 EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 166
EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL
Sbjct: 75 EVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEAL 134
Query: 167 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 226
WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV
Sbjct: 135 WELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEV 194
Query: 227 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 286
LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA
Sbjct: 195 LGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHA 254
Query: 287 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 346
FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF
Sbjct: 255 FVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESF 314
Query: 347 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 406
LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH
Sbjct: 315 LRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEH 374
Query: 407 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 466
TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL
Sbjct: 375 TRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPL 434
Query: 467 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 526
RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL
Sbjct: 435 RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKREL 494
Query: 527 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 586
LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS
Sbjct: 495 LTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTS 554
Query: 587 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 646
DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA
Sbjct: 555 DSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSA 614
Query: 647 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 706
PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE
Sbjct: 615 PELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGE 674
Query: 707 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 766
SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT
Sbjct: 675 SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLT 734
Query: 767 RAQLQRMRGPHIIQLDTPLSASEV 790
RAQLQRMRGPHIIQLDTPLSASEV
Sbjct: 735 RAQLQRMRGPHIIQLDTPLSASEV 758
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 421 bits (1083), Expect = e-117
Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)
Query: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138
R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D
Sbjct: 249 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308
Query: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193
L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN
Sbjct: 309 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253
LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F
Sbjct: 369 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428
Query: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313
G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+
Sbjct: 429 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488
Query: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373
TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y
Sbjct: 489 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548
Query: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433
EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608
Query: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493
+D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A
Sbjct: 609 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668
Query: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536
W++ AQ LQ+L+A+E ++ L +L ++D +
Sbjct: 669 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728
Query: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588
SP+ R S+ S + +++G T + ++ P ++ + P S
Sbjct: 729 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788
Query: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644
T TPT PL + R+ D T S L+D + P P P+AP+
Sbjct: 789 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847
Query: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701
P P P + PP + + AS +++ L A G PS+P+ +
Sbjct: 848 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901
Query: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746
S A +P + G +E GP + G S L A + R+
Sbjct: 902 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961
Query: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790
AS R++ P ++ RKLT AQL R+R + L++ L+ASEV
Sbjct: 962 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006
>gi|111154084 pleckstrin homology domain containing family G member 5
isoform b [Homo sapiens]
Length = 1083
Score = 421 bits (1083), Expect = e-117
Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)
Query: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138
R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D
Sbjct: 326 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 385
Query: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193
L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN
Sbjct: 386 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 445
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253
LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F
Sbjct: 446 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 505
Query: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313
G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+
Sbjct: 506 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 565
Query: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373
TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y
Sbjct: 566 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 625
Query: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433
EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 626 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 685
Query: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493
+D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A
Sbjct: 686 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 745
Query: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536
W++ AQ LQ+L+A+E ++ L +L ++D +
Sbjct: 746 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 805
Query: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588
SP+ R S+ S + +++G T + ++ P ++ + P S
Sbjct: 806 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 865
Query: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644
T TPT PL + R+ D T S L+D + P P P+AP+
Sbjct: 866 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 924
Query: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701
P P P + PP + + AS +++ L A G PS+P+ +
Sbjct: 925 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 978
Query: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746
S A +P + G +E GP + G S L A + R+
Sbjct: 979 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1038
Query: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790
AS R++ P ++ RKLT AQL R+R + L++ L+ASEV
Sbjct: 1039 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1083
>gi|111154088 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 421 bits (1083), Expect = e-117
Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)
Query: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138
R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D
Sbjct: 249 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308
Query: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193
L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN
Sbjct: 309 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253
LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F
Sbjct: 369 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428
Query: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313
G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+
Sbjct: 429 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488
Query: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373
TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y
Sbjct: 489 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548
Query: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433
EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608
Query: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493
+D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A
Sbjct: 609 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668
Query: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536
W++ AQ LQ+L+A+E ++ L +L ++D +
Sbjct: 669 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728
Query: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588
SP+ R S+ S + +++G T + ++ P ++ + P S
Sbjct: 729 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788
Query: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644
T TPT PL + R+ D T S L+D + P P P+AP+
Sbjct: 789 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847
Query: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701
P P P + PP + + AS +++ L A G PS+P+ +
Sbjct: 848 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901
Query: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746
S A +P + G +E GP + G S L A + R+
Sbjct: 902 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961
Query: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790
AS R++ P ++ RKLT AQL R+R + L++ L+ASEV
Sbjct: 962 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006
>gi|111154080 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 421 bits (1083), Expect = e-117
Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)
Query: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138
R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D
Sbjct: 249 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 308
Query: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193
L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN
Sbjct: 309 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 368
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253
LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F
Sbjct: 369 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 428
Query: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313
G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+
Sbjct: 429 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 488
Query: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373
TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y
Sbjct: 489 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 548
Query: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433
EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 549 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 608
Query: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493
+D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A
Sbjct: 609 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 668
Query: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536
W++ AQ LQ+L+A+E ++ L +L ++D +
Sbjct: 669 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 728
Query: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588
SP+ R S+ S + +++G T + ++ P ++ + P S
Sbjct: 729 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 788
Query: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644
T TPT PL + R+ D T S L+D + P P P+AP+
Sbjct: 789 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 847
Query: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701
P P P + PP + + AS +++ L A G PS+P+ +
Sbjct: 848 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 901
Query: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746
S A +P + G +E GP + G S L A + R+
Sbjct: 902 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 961
Query: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790
AS R++ P ++ RKLT AQL R+R + L++ L+ASEV
Sbjct: 962 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1006
>gi|111154078 pleckstrin homology domain containing family G member 5
isoform c [Homo sapiens]
Length = 1062
Score = 421 bits (1083), Expect = e-117
Identities = 282/767 (36%), Positives = 407/767 (53%), Gaps = 67/767 (8%)
Query: 82 RHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPE---DRRHWEIGEGGDSG 138
R G +G S +E+ K +LE +LHT+S+FG+PRLP D WE D
Sbjct: 305 RFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDED 364
Query: 139 -----LTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLN 193
L +E SWREL+ GH+++++ CHQQEA+WELL TE Y+RKL+++ +L LLN
Sbjct: 365 EDNACLRLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLN 424
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTF 253
LQ GLL EV AE LF N+P + + HR W V+ P LE+ R + L P GF F
Sbjct: 425 LQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMF 484
Query: 254 GQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRI 313
G F PY++YC+ + M Y R N LF A++ W EKH + R L D+L KPHQR+
Sbjct: 485 GSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRL 544
Query: 314 TKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPY 373
TKYPLLL +VL+++ E RA+EA+ AMI +VE F+ H+N +RQ +E++ LAA RI Y
Sbjct: 545 TKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAY 604
Query: 374 EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLF 433
EV+E SDEV+K L+ F LDLT+P+ G + E TRQLLLEG +R+KEG++ K+DVY FLF
Sbjct: 605 EVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLF 664
Query: 434 SDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPS 493
+D+LLVTK +KA++ +VIRPPL+++K+VC+ LRDP SFLLI+L EF A
Sbjct: 665 TDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASG 724
Query: 494 PTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRE----------------- 536
W++ AQ LQ+L+A+E ++ L +L ++D +
Sbjct: 725 QALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEEEEEEEEEGEDSG 784
Query: 537 -----SPS-TRPSTPSLEGSQSSAEGRTPEFSTII--PHLVVTEDTDEDAPLVPDDTSDS 588
SP+ R S+ S + +++G T + ++ P ++ + P S
Sbjct: 785 TSAASSPTIMRKSSGSPDSQHCASDGSTETLAMVVVEPGDTLSSPEFDSGPFSSQSDETS 844
Query: 589 GYGTLIPGTPTGSRSPLSRLRQRALRRDPRL-TFSTLELRDIPLRPHPPD---PQAPQRR 644
T TPT PL + R+ D T S L+D + P P P+AP+
Sbjct: 845 LSTTASSATPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDF-VAPGPMAELVPRAPESP 903
Query: 645 SAPELPEGILKGGSLPQE---DPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHA 701
P P P + PP + + AS +++ L A G PS+P+ +
Sbjct: 904 RVPSPPPSPRLRRRTPVQLLSCPPHLLKSKSEAS-----LLQLLAGAGTHG-TPSAPSRS 957
Query: 702 DS----AGESPW-ESSGEEEEEGPLFLKAGHTS------LRPMRAEDMLREIREEL---- 746
S A +P + G +E GP + G S L A + R+
Sbjct: 958 LSELCLAVPAPGIRTQGSPQEAGPSWDCRGAPSPGSGPGLVGCLAGEPAGSHRKRCGDLP 1017
Query: 747 --ASQRIEGAEEPR-DSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV 790
AS R++ P ++ RKLT AQL R+R + L++ L+ASEV
Sbjct: 1018 SGASPRVQPEPPPGVSAQHRKLTLAQLYRIR--TTLLLNSTLTASEV 1062
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 103 bits (256), Expect = 8e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 396 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 455
Query: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 456 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 508
Query: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295
S F RF C R + + +Q +P F AFVQ E
Sbjct: 509 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 562
Query: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 563 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 622
Query: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 623 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 668
Query: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 669 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 696
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 103 bits (256), Expect = 8e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 348 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 407
Query: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 408 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 460
Query: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295
S F RF C R + + +Q +P F AFVQ E
Sbjct: 461 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 514
Query: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 515 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 574
Query: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 575 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 620
Query: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 621 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 103 bits (256), Expect = 8e-22
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 43/328 (13%)
Query: 132 GEGGDSGLTIEKS----WRELVPGHK--EMSQELCHQQEALWELLTTELIYVRKLKIMTD 185
GE G SGL +E WRELVP + + +QE + ELL TE +VR L+++ D
Sbjct: 381 GEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHD 440
Query: 186 LLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG 245
L + L + +F ++ LI H F D ++ + + SG ++ IG
Sbjct: 441 LFFQPMAECLFFPL---EELQNIFPSLDELIEVHSLFLDRLM----KRRQESGYLIEEIG 493
Query: 246 ----------LQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHK 295
S F RF C R + + +Q +P F AFVQ E
Sbjct: 494 DVLLARFDGAEGSWFQKISSRF------CSRQSFALEQLKAKQRKDPRFCAFVQEAESRP 547
Query: 296 RSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVR 355
R R L D++ QR+TKYPLLL ++ + + E +E + E L H+N VR
Sbjct: 548 RCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVR 607
Query: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
E+ L +R+ L SD + L F LD+T ++L+ EGP
Sbjct: 608 DMEDLLRLKDYQRRL-DLSHLRQSSDPM---LSEFKNLDITK----------KKLVHEGP 653
Query: 416 VRVKEGREGKLDVYLFLFSDVLLVTKPQ 443
+ + ++ ++V++ L D+LL+ + Q
Sbjct: 654 LTWRVTKDKAVEVHVLLLDDLLLLLQRQ 681
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 96.3 bits (238), Expect = 1e-19
Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)
Query: 63 SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119
S LS L +P P +G + SP L T H LE L S
Sbjct: 693 SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 748
Query: 120 RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179
P D ++W+ G D +V G ++Q +QE + EL TE ++R
Sbjct: 749 --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 792
Query: 180 LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239
L+++ DL+ +++ L+ LF N+P LI H S W E + EE +
Sbjct: 793 LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 848
Query: 240 PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299
D + + + Q+C + + +Q F F+Q E H + R
Sbjct: 849 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 908
Query: 300 QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358
L DL+I QR+TKYPLLL +++K + ++ E L + L+++N V+Q E
Sbjct: 909 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 968
Query: 359 EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418
+ L +R+ LE S+ + F +LDLT TR+++ EGP+
Sbjct: 969 NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 1014
Query: 419 KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464
+ ++ LD+++ L D+L++ + Q + +D + P L L ++ +
Sbjct: 1015 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1074
Query: 465 PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507
+ D +F +I ++ LV S +D+ W+E ++A
Sbjct: 1075 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1117
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 96.3 bits (238), Expect = 1e-19
Identities = 113/464 (24%), Positives = 195/464 (42%), Gaps = 58/464 (12%)
Query: 63 SGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKA---HELEVRLHTFSMFGMP 119
S LS L +P P +G + SP L T H LE L S
Sbjct: 653 SSSTSSLSTRSLENPTPP--FTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLE-- 708
Query: 120 RLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRK 179
P D ++W+ G D +V G ++Q +QE + EL TE ++R
Sbjct: 709 --PEPDAQNWQHTVGKD-----------VVAG---LTQREIDRQEVINELFVTEASHLRT 752
Query: 180 LKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQ 239
L+++ DL+ +++ L+ LF N+P LI H S W E + EE +
Sbjct: 753 LRVL-DLIF--YQRMKKENLMPREELARLFPNLPELIEIHNS-WCEAMKKLREEGPIIKE 808
Query: 240 PLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299
D + + + Q+C + + +Q F F+Q E H + R
Sbjct: 809 ISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRR 868
Query: 300 QMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGE 358
L DL+I QR+TKYPLLL +++K + ++ E L + L+++N V+Q E
Sbjct: 869 LQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTE 928
Query: 359 EQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRV 418
+ L +R+ LE S+ + F +LDLT TR+++ EGP+
Sbjct: 929 NRHRLEGYQKRLDA-TALERASNPLAAE---FKSLDLT----------TRKMIHEGPLTW 974
Query: 419 KEGREGKLDVYLFLFSDVLLVTKPQRK--------------ADKAKVIRPPLMLEKLVCQ 464
+ ++ LD+++ L D+L++ + Q + +D + P L L ++ +
Sbjct: 975 RISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIR 1034
Query: 465 PL-RDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQA 507
+ D +F +I ++ LV S +D+ W+E ++A
Sbjct: 1035 SVATDKRAFFIICTSKLGPPQIYELVALTS-SDKNTWMELLEEA 1077
>gi|51972240 pleckstrin homology domain containing, family G (with
RhoGef domain) member 7 [Homo sapiens]
Length = 379
Score = 92.8 bits (229), Expect = 1e-18
Identities = 86/358 (24%), Positives = 156/358 (43%), Gaps = 45/358 (12%)
Query: 194 LQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRAS--GQPLDPIGLQSGFL 251
LQ L++V LF N+ L +T F + + G + AS LD I + + +
Sbjct: 10 LQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKDYVDASEISSSLDFISVLTKYF 69
Query: 252 TFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQ 311
G + YCL + Y ++ + F +++WCE++++ R + +LL+ P Q
Sbjct: 70 R-GSLCQSHQTYCLNYSAAIFYLESLRQRDD-FGIYLKWCEQNEQCRRLHVPELLVAPLQ 127
Query: 312 RITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIG 371
R+T+YPLLL + KRS ++ + + ++ E VE +R + G+V+ + + + I
Sbjct: 128 RLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEGKVKWLDNFQKFRYLQEII- 186
Query: 372 PYEVLEPPSDEVEKNLRPFSTLDLTSPML--GVASEHTRQLLLEGPVRVKEGREGKLDVY 429
V P D ++ P + + + S +R LL EG + + E LDVY
Sbjct: 187 ---VWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEGKLTLAESTR-FLDVY 242
Query: 430 LFLFSDVLLVTKPQ--------------------------RKADKAKVIRPPLMLEKLVC 463
LFLF+D LLVTK + ++ V+ P+ L++LV
Sbjct: 243 LFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSCTVLDQPIPLDRLVV 302
Query: 464 QPLRD--------PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 513
+ + N+FL+ H ++ +A L+ + + W+ + A + K
Sbjct: 303 KSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWMAQITTAISCFTK 360
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/308 (24%), Positives = 137/308 (44%), Gaps = 30/308 (9%)
Query: 144 SWRELVPGHKEMSQELCH--QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM 201
+W++LV + + C +QE + EL TE +VR LK++ + + R G+L
Sbjct: 768 NWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQ---RVSREGILS 824
Query: 202 EVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIG--LQSGFLTFGQRF-- 257
+F N+ +++ H +++ R +D IG L + F G+
Sbjct: 825 PSELRKIFSNLEDILQLHIGLNEQMKAV---RKRNETSVIDQIGEDLLTWFSGPGEEKLK 881
Query: 258 HPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYP 317
H +C + + +Q+ + F FVQ E + R L D++ QR+TKYP
Sbjct: 882 HAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYP 941
Query: 318 LLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRI--GPYEV 375
LLL + K + +E + + L ++N V++ E ++ L +R+ ++
Sbjct: 942 LLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKL 1001
Query: 376 LEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSD 435
E P+ E +N LDLT R+++ EGP+ K R+ +D+Y L D
Sbjct: 1002 SEYPNVEELRN------LDLTK----------RKMIHEGPLVWKVNRDKTIDLYTLLLED 1045
Query: 436 VLLVTKPQ 443
+L++ + Q
Sbjct: 1046 ILVLLQKQ 1053
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 79.7 bits (195), Expect = 1e-14
Identities = 94/393 (23%), Positives = 169/393 (43%), Gaps = 61/393 (15%)
Query: 162 QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRS 221
+Q + EL+ TE YV L+++T++ L+ + LL E +F N LI +
Sbjct: 1238 RQGYIHELIVTEENYVNDLQLVTEIFQKPLMESE---LLTEKEVAMIFVNWKELIMCNI- 1293
Query: 222 FWDEVLGPTLEETRASGQPLDPIGLQSGFLTFG-QRFHPYVQYCLRVKQTMAYAREQQET 280
++L + SG+ + P+ + L+ PY+++C R A +++ +
Sbjct: 1294 ---KLLKALRVRKKMSGEKM-PVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDE 1349
Query: 281 NPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEA-LNAM 339
P F FV+ R L ++KP QR+T+YPL++ +L+ +PE + L
Sbjct: 1350 APDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHA 1409
Query: 340 IEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPM 399
+E E +N VR+ E + L + I + E S+++ N S + P
Sbjct: 1410 LEKAEELCSQVNEGVREKENSDRL----EWIQAHVQCEGLSEQLVFN----SVTNCLGP- 1460
Query: 400 LGVASEHTRQLLLEGPV-RVKEGREGKLDVYLFLFSDVLL---VTKPQRKADKAKVIRP- 454
R+ L G + + K +E +Y FLF+D LL +TKP + KV P
Sbjct: 1461 --------RKFLHSGKLYKAKSNKE----LYGFLFNDFLLLTQITKPLGSSGTDKVFSPK 1508
Query: 455 ----------PLMLEKLVCQPLRDPN-SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEK 503
P+ L +++ + DP+ + H++ + + S +R W++K
Sbjct: 1509 SNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISH---IDRVYTLRAESINERTAWVQK 1565
Query: 504 TQQAQAALQKLKAEEYVQ---QKRELLTLYRDQ 533
+ A +E Y++ +KRE L R Q
Sbjct: 1566 IKAA--------SELYIETEKKKREKAYLVRSQ 1590
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 79.7 bits (195), Expect = 1e-14
Identities = 153/674 (22%), Positives = 257/674 (38%), Gaps = 96/674 (14%)
Query: 156 SQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSL 215
S +L + + E+L TE YV+ LK + + + + ++ L E LFGN+ +
Sbjct: 108 SPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTE-ERSALFGNIQDI 166
Query: 216 IRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAR 275
F E+L LE DP+ + F++ + FH Y QYC +++A
Sbjct: 167 YH----FNSELL-QDLENCEN-----DPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLT 216
Query: 276 EQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEA 335
E L F + E K S L L+KP QRI KY LLLH + + + E
Sbjct: 217 ECMRNKILAKFFRERQETLKHS--LPLGSYLLKPVQRILKYHLLLHEI--ENHLDKDTEG 272
Query: 336 LNAMIEAVESFLR---HINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFST 392
+ +++A+++ R HIN R+ E L E++ L +
Sbjct: 273 YDVVLDAIDTMQRVAWHINDMKRKHEHAVRL-----------------QEIQSLLTNWKG 315
Query: 393 LDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRK--ADKAK 450
DLTS +L+LEG R++ + + LFLF +LL+TK + KA
Sbjct: 316 PDLTS---------YGELVLEGTFRIQRAKNERT---LFLFDKLLLITKKRDDTFTYKAH 363
Query: 451 VIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQ----Q 506
++ LML +++ ++P SF + H ++ V S D+ W+ + +
Sbjct: 364 ILCGNLMLVEVI---PKEPLSFSVFH---YKNPKLQHTVQAKSQQDKRLWVLHLKRLILE 417
Query: 507 AQAALQKLKAEEYVQQKRELLTLYRDQDRESP--STRPSTPSLEGSQSSAEGRTPEFSTI 564
AA KA++ + E+ ++ SP T+ S EGS R E S+
Sbjct: 418 NHAAKIPAKAKQAI---LEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSR 474
Query: 565 IPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRL----T 620
++ T +T +D V + + P + P S LR L T
Sbjct: 475 SHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWT 534
Query: 621 FSTLELRDIPLRPHP---PDPQAPQRRSAPELPEGILKGGSLPQED----PPTWSEEEDG 673
+ P R P D + + P L L ++ P +W +
Sbjct: 535 DHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQME 594
Query: 674 ASERGNVVVETLHRARLRG----------------QLPSSPTHADSAGESPWESSGE--E 715
++E + + RA G +L +SP +P+ SS E
Sbjct: 595 STETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTI 654
Query: 716 EEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRG 775
++ ++ + L+ M A+ RE E S+ + P+ + T+ Q +G
Sbjct: 655 DDIDHVYDNISYEDLKLMVAK---REEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKG 711
Query: 776 PHIIQLDTPLSASE 789
Q D LS E
Sbjct: 712 SLYAQTDGTLSGGE 725
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 79.7 bits (195), Expect = 1e-14
Identities = 100/435 (22%), Positives = 180/435 (41%), Gaps = 60/435 (13%)
Query: 118 MPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV 177
+P++ P++ ++GE DS T +K+ ++ Q+L H + ELL TE YV
Sbjct: 117 VPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQ---ELLHTEETYV 173
Query: 178 RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW-DEVLGPTLEETRA 236
++L ++ + L + G+ EV +F N+ S+ R H F E+ EE
Sbjct: 174 KRLHLLDQVFCTRLTD---AGIPPEVIMG-IFSNISSIHRFHGQFLLPELKTRITEEWDT 229
Query: 237 SGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKR 296
+ + D + + FL Y +Y + + + +PLF V +K +
Sbjct: 230 NPRLGDILQKLAPFLKM------YGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 297 SGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQEALNAMIEAVESFLRHINGQVR 355
G L +++P QR+ +Y LLL LKR P +A ++ +E + + H N +R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
+ E+ L +++G E + P++E L+ EG
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANE---------------------------LIKEGQ 376
Query: 416 VRVKEGREG-KLDVYLFLFSDVLLVTKPQRKADKAKV-IRPPLMLEKLVCQPLRDPNSFL 473
++ + G D +LFLF+ ++L P+ + K +R + + L Q + PN+
Sbjct: 377 IQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNT-- 434
Query: 474 LIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYR-- 531
H +L + + ++ +W+ Q QA ++K K Q E +
Sbjct: 435 -AHTFIITGRKRSLELQTRTEEEKKEWI---QIIQATIEKHK------QNSETFKAFGGA 484
Query: 532 -DQDRESPSTRPSTP 545
QD E PS P P
Sbjct: 485 FSQD-EDPSLSPDMP 498
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 79.7 bits (195), Expect = 1e-14
Identities = 100/435 (22%), Positives = 180/435 (41%), Gaps = 60/435 (13%)
Query: 118 MPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV 177
+P++ P++ ++GE DS T +K+ ++ Q+L H + ELL TE YV
Sbjct: 117 VPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQ---ELLHTEETYV 173
Query: 178 RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFW-DEVLGPTLEETRA 236
++L ++ + L + G+ EV +F N+ S+ R H F E+ EE
Sbjct: 174 KRLHLLDQVFCTRLTD---AGIPPEVIMG-IFSNISSIHRFHGQFLLPELKTRITEEWDT 229
Query: 237 SGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKR 296
+ + D + + FL Y +Y + + + +PLF V +K +
Sbjct: 230 NPRLGDILQKLAPFLKM------YGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
Query: 297 SGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQEALNAMIEAVESFLRHINGQVR 355
G L +++P QR+ +Y LLL LKR P +A ++ +E + + H N +R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
Query: 356 QGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGP 415
+ E+ L +++G E + P++E L+ EG
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANE---------------------------LIKEGQ 376
Query: 416 VRVKEGREG-KLDVYLFLFSDVLLVTKPQRKADKAKV-IRPPLMLEKLVCQPLRDPNSFL 473
++ + G D +LFLF+ ++L P+ + K +R + + L Q + PN+
Sbjct: 377 IQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNT-- 434
Query: 474 LIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYR-- 531
H +L + + ++ +W+ Q QA ++K K Q E +
Sbjct: 435 -AHTFIITGRKRSLELQTRTEEEKKEWI---QIIQATIEKHK------QNSETFKAFGGA 484
Query: 532 -DQDRESPSTRPSTP 545
QD E PS P P
Sbjct: 485 FSQD-EDPSLSPDMP 498
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 75.5 bits (184), Expect = 2e-13
Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)
Query: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202
W E+ + + ++ +QEA++E+ E + LK+ +L L ++ E
Sbjct: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212
Query: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262
+FG++ S I H +++L E T+ G ++ IG +++ R + Y
Sbjct: 213 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 265
Query: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322
YC A +Q++ +P F+Q C + S + L L P R+ KYPLLL
Sbjct: 266 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324
Query: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381
+LK +P+ + L I ++ L IN +++GE + I E L D
Sbjct: 325 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 373
Query: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
E +++ R E ++ LL G +R K G + +Y+FLF D+L++T+
Sbjct: 374 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 414
Query: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468
P + ++ +V R P+ +++LV + L+D
Sbjct: 415 PVTRNERHSYQVYRQPIPVQELVLEDLQD 443
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 75.5 bits (184), Expect = 2e-13
Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)
Query: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202
W E+ + + ++ +QEA++E+ E + LK+ +L L ++ E
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 158
Query: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262
+FG++ S I H +++L E T+ G ++ IG +++ R + Y
Sbjct: 159 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 211
Query: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322
YC A +Q++ +P F+Q C + S + L L P R+ KYPLLL
Sbjct: 212 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270
Query: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381
+LK +P+ + L I ++ L IN +++GE + I E L D
Sbjct: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 319
Query: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
E +++ R E ++ LL G +R K G + +Y+FLF D+L++T+
Sbjct: 320 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 360
Query: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468
P + ++ +V R P+ +++LV + L+D
Sbjct: 361 PVTRNERHSYQVYRQPIPVQELVLEDLQD 389
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 75.5 bits (184), Expect = 2e-13
Identities = 89/358 (24%), Positives = 146/358 (40%), Gaps = 53/358 (14%)
Query: 166 LWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDE 225
L E+ TE Y R L+ D+ + L+ V L +F N+ LI+ H SF
Sbjct: 198 LLEIQETEAKYYRTLE---DIEKNYMSPLRLV--LSPADMAAVFINLEDLIKVHHSF--- 249
Query: 226 VLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFH 285
L G L + FL F +R Y +YC ++ + + F
Sbjct: 250 -LRAIDVSVMVGGSTLAKV-----FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFR 303
Query: 286 AFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVES 345
V+ C + G+ L DLL+ P QR+ KY LLL +L S E ++ L +EA++
Sbjct: 304 QKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQD 363
Query: 346 FLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASE 405
+IN +V++ +E LR S + L V E
Sbjct: 364 LAMYIN-EVKRDKE--------------------------TLRKISEFQSSIENLQVKLE 396
Query: 406 HTRQLLLEGPVRVKE-GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQ 464
+ ++G ++V+ K D YLFLF V++V K + + + K I L+ K+
Sbjct: 397 EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEI-IELLFHKMTDD 455
Query: 465 PLRDPN------SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKA 516
P+ + + F LIHL Q C + + +W+E+ + A + ++ KA
Sbjct: 456 PMNNKDVKKWSYGFYLIHLQGKQ----GFQFFCKTEDMKRKWMEQFEMAMSNIKPDKA 509
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 74.3 bits (181), Expect = 4e-13
Identities = 96/368 (26%), Positives = 151/368 (41%), Gaps = 52/368 (14%)
Query: 162 QQEALW----ELLTTELIYVRKLKIMTDLLAAGLLNLQRVG--LLMEVSAETLFGNVPSL 215
+Q A W EL TE YV L + L L + G +L +T+FG++P +
Sbjct: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477
Query: 216 IRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQ----RFHPYVQYCLRVKQTM 271
H D+ LE+ + IG FL + + + P+V + K+T+
Sbjct: 478 FDVHTKIKDD-----LEDLIVNWDESKSIG--DIFLKYSKDLVKTYPPFVNFFEMSKETI 530
Query: 272 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEAR 331
+Q+ P FHAF++ + GRQ L +LLI+P QR+ LLL+ + K + +
Sbjct: 531 IKCEKQK---PRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADEN 587
Query: 332 AQEA-LNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 390
++ L I +++ + HIN R+ E Q+ + YEV P++ + +
Sbjct: 588 PDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVV-----YEVDGCPANLLSSHRSLV 642
Query: 391 STLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA---- 446
++ S L E P E V LFLF+D L + + + K
Sbjct: 643 QRVETIS-------------LGEHPCDRGE------QVTLFLFNDCLEIARKRHKVIGTF 683
Query: 447 -DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQ 505
RPP L+ + PL L I TE + ALLV PT++A L Q
Sbjct: 684 RSPHGQTRPPASLKHIHLMPLSQIKKVLDIRETEDCHNAFALLVR--PPTEQANVLLSFQ 741
Query: 506 QAQAALQK 513
L K
Sbjct: 742 MTSDELPK 749
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 74.3 bits (181), Expect = 4e-13
Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 54/385 (14%)
Query: 154 EMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVP 213
++S E +QEA++E+LT+E Y L I+ + L + + + ++ LF N+
Sbjct: 277 QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQMEHHHLFSNIL 333
Query: 214 SLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLT--FGQRFHPYVQYCLRVKQTM 271
++ + F++++ E R Q L + S L + FHPY+ YC
Sbjct: 334 DVLGASQRFFEDL------EQRHKAQVL--VEDISDILEEHAEKHFHPYIAYCSNEVYQQ 385
Query: 272 AYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAV-LKRSPEA 330
++ +N F ++ E+ G + LI P QR+T+ PLL+ + LK +
Sbjct: 386 RTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHS 445
Query: 331 RAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPF 390
+A + ++A+ +R N + E E + ++ +V P + L
Sbjct: 446 ERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKR 505
Query: 391 STLDL---TSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD 447
L L T +AS T YLFLF+DVL+VTK +K++
Sbjct: 506 GELFLVEETGLFRKIASRPT--------------------CYLFLFNDVLVVTK--KKSE 543
Query: 448 KAKVIRPPLMLEKLVCQPLRD---------------PNSFLLIHLTEFQCVSSALLVHCP 492
++ +++ + + + + P+ F + L + LL+
Sbjct: 544 ESYMVQDYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSD 603
Query: 493 SPTDRAQWLEKTQQAQAALQKLKAE 517
S +DRA+W+ ++ Q L ++
Sbjct: 604 SASDRARWIVALTHSERQWQGLSSK 628
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 73.9 bits (180), Expect = 5e-13
Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 27/288 (9%)
Query: 155 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 214
+SQE +QEA++E++++E Y+ L+I+ + + + + + LF N+
Sbjct: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKN---SKELSDTMTKTERHHLFSNITD 489
Query: 215 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA 274
+ + F+ E LE + +D I T F PYV+YC
Sbjct: 490 VCEASKKFFIE-----LEARHQNNIFIDDISDIVEKHT-ASTFDPYVKYCTNEVYQQRTL 543
Query: 275 REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQ 333
++ TNP F + E H+ + LI P QR+T+ PLL+ + +++P ++
Sbjct: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
Query: 334 EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTL 393
E ++ V +R N R+ E E + Y + + ++E ++PF
Sbjct: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMM---------YTI----NSQLEFKIKPF--- 647
Query: 394 DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
L S + +E V R K VY FLF+DVL++TK
Sbjct: 648 PLVSSSRWLVKRGELTAYVEDTVLFSR-RTSKQQVYFFLFNDVLIITK 694
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 7e-13
Identities = 85/363 (23%), Positives = 152/363 (41%), Gaps = 54/363 (14%)
Query: 162 QQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLM-EVSAETLFGNVPSLIRTHR 220
+++ + ELL TE YV +L ++ + LL R E +F N+ S+ + H
Sbjct: 103 EKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHS 162
Query: 221 SFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQET 280
F+ L L++ A+ + D I + FL Y +Y ++ +
Sbjct: 163 QFFLPELQRRLDDWTANPRIGDVIQKLAPFLKM------YSEYVKNFERAAELLATWTDK 216
Query: 281 NPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-----EARAQEA 335
+PLF + + + SG L +++P QRI +Y LLL +++ P +A AQ+A
Sbjct: 217 SPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKA 276
Query: 336 LNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDL 395
L+ + A + H N + + E + L QR+G + + PS+
Sbjct: 277 LDMIFSAAQ----HSNAAITEMERLQDLWEVYQRLGLEDDIVDPSN-------------- 318
Query: 396 TSPMLGVASEHTRQLLLEGPV-RVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKV-IR 453
LL EGPV ++ R ++ YLFLF+++LL P+ A+ +R
Sbjct: 319 -------------TLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVR 365
Query: 454 PPLMLEKLVCQPLRD---PNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAA 510
+ + + + L D P+SFL+ L + S + W++ Q A
Sbjct: 366 TRIDVAGMKVRELMDAEFPHSFLV------SGKQRTLELQARSQEEMISWMQAFQAAIDQ 419
Query: 511 LQK 513
++K
Sbjct: 420 IEK 422
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 73.6 bits (179), Expect = 7e-13
Identities = 89/363 (24%), Positives = 146/363 (40%), Gaps = 58/363 (15%)
Query: 166 LWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDE 225
L E+ TE Y R L+ D+ + L+ V L +F N+ LI+ H SF
Sbjct: 203 LLEIQETEAKYYRTLE---DIEKNYMSPLRLV--LSPADMAAVFINLEDLIKVHHSF--- 254
Query: 226 VLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFH 285
L G L + FL F +R Y +YC ++ + + F
Sbjct: 255 -LRAIDVSVMVGGSTLAKV-----FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFR 308
Query: 286 AFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVES 345
V+ C + G+ L DLL+ P QR+ KY LLL +L S E ++ L +EA++
Sbjct: 309 QKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQD 368
Query: 346 FLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASE 405
+IN +V++ +E LR S + L V E
Sbjct: 369 LAMYIN-EVKRDKE--------------------------TLRKISEFQSSIENLQVKLE 401
Query: 406 HTRQLLLEGPVRVKE-GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQ 464
+ ++G ++V+ K D YLFLF V++V K + + + K I L+ K+
Sbjct: 402 EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEI-IELLFHKMTDD 460
Query: 465 PLRDPN-----------SFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQK 513
P+ + + F LIHL Q C + + +W+E+ + A + ++
Sbjct: 461 PMNNKDVKKSHGKMWSYGFYLIHLQGKQ----GFQFFCKTEDMKRKWMEQFEMAMSNIKP 516
Query: 514 LKA 516
KA
Sbjct: 517 DKA 519
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 226 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 282
Query: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 283 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 341
Query: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 342 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 398
Query: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 399 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 451
Query: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 452 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 501
Query: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 502 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 550
Query: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 551 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 608
Query: 532 DQ 533
++
Sbjct: 609 EK 610
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 227 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 283
Query: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 284 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 342
Query: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 343 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 399
Query: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 400 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 452
Query: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 453 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 502
Query: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 503 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 551
Query: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 552 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 609
Query: 532 DQ 533
++
Sbjct: 610 EK 611
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 71.6 bits (174), Expect = 3e-12
Identities = 108/422 (25%), Positives = 176/422 (41%), Gaps = 78/422 (18%)
Query: 153 KEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNV 212
++ +E+ QQ+ ++EL+ TEL +VR LKIMT L G+L L + LF V
Sbjct: 199 QQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELH---LEPGVVQGLFPCV 255
Query: 213 PSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHP--------YVQYC 264
L H F ++L + G + + + G L Q P Y ++C
Sbjct: 256 DELSDIHTRFLSQLL-ERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFC 314
Query: 265 LRVKQTMAYAREQQETNPLFHAFVQWCEKH---KRSGRQMLCDLLIKPHQRITKYPLLLH 321
R + + +E + F F++ + KR G Q C LL+ QRITKYPLL+
Sbjct: 315 SRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQE-CILLVT--QRITKYPLLIS 371
Query: 322 AVLKRSP--EARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 379
+L+ S E Q+ A+ ++ + V +G Q A Q I Y ++P
Sbjct: 372 RILQHSHGIEEERQDLTTAL-----GLVKELLSNVDEGIYQLEKGARLQEI--YNRMDPR 424
Query: 380 SDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVL-- 437
+ PF +L R+L+ +G + K DV + L +DVL
Sbjct: 425 AQTPVPGKGPFGREELL----------RRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVF 474
Query: 438 LVTKPQR----KADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSA----LLV 489
L K Q+ DK V+ L+ L+ + + + + + +S+A V
Sbjct: 475 LQEKDQKYIFPTLDKPSVV----SLQNLIVRDIANQEKGMFL-------ISAAPPEMYEV 523
Query: 490 HCPSPTDRAQWLEKTQQA-----------------QAALQKLKAEEYVQQK-RELLTLYR 531
H S DR+ W+ QQ+ +A L+++K E +QQK R L+ L R
Sbjct: 524 HTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKME--LQQKDRALVELLR 581
Query: 532 DQ 533
++
Sbjct: 582 EK 583
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,097,217
Number of Sequences: 37866
Number of extensions: 1877275
Number of successful extensions: 8544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 8032
Number of HSP's gapped (non-prelim): 640
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.