Guide to the Human Genome
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Name: DOT1L Sequence: fasta or formatted (1537aa) NCBI GI: 22094135
Description:

DOT1-like, histone H3 methyltransferase

Referenced in:

Histones, Related Proteins, and Modifying Enzymes

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             9.8        150           3
 C cysteine            0.8         13           1
 D aspartate           3.8         58           3
 E glutamate           6.2         96           3
 F phenylalanine       2.4         37           1
 G glycine             7.7        119           3
 H histidine           2.5         39           2
 I isoleucine          2.9         44           2
 K lysine              6.4         99           3
 L leucine            11.1        170           3
 M methionine          1.2         19           1
 N asparagine          3.1         48           2
 P proline             8.7        133           2
 Q glutamine           5.1         79           2
 R arginine            5.5         84           3
 S serine             12.0        184           4
 T threonine           4.2         65           2
 V valine              4.0         62           2
 W tryptophan          0.6          9           1
 Y tyrosine            1.9         29           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   DOT1-like, histone H3 methyltransferase 
FLJ22184              0.015   PREDICTED: hypothetical protein LOC80164 
FLJ22184              0.013   PREDICTED: hypothetical protein FLJ22184 
MUC17                 0.013   mucin 17 
FLJ22184              0.012   PREDICTED: hypothetical protein FLJ22184 
NACA                  0.012   nascent polypeptide-associated complex alpha subuni...
MUC6                  0.011   mucin 6, gastric 
SRRM2                 0.011   splicing coactivator subunit SRm300 
CIC                   0.009   capicua homolog 
ZNF853                0.009   zinc finger protein 853 
MLL2                  0.009   myeloid/lymphoid or mixed-lineage leukemia 2 
SRCAP                 0.009   Snf2-related CBP activator protein 
CEP250                0.008   centrosomal protein 2 
MAD1L1                0.008   MAD1-like 1 protein 
MAD1L1                0.008   MAD1-like 1 protein 
MAD1L1                0.008   MAD1-like 1 protein 
TNRC18                0.008   trinucleotide repeat containing 18 
C1orf113              0.008   SH3 domain-containing protein C1orf113 isoform 1 [H...
C1orf113              0.008   SH3 domain-containing protein C1orf113 isoform 2 [H...
LOC100133915          0.008   PREDICTED: hypothetical protein 
MYH10                 0.008   myosin, heavy polypeptide 10, non-muscle 
MYH13                 0.008   myosin, heavy polypeptide 13, skeletal muscle [Homo...
CCDC88A               0.008   coiled-coil domain containing 88A isoform 2 
CCDC88A               0.008   coiled-coil domain containing 88A isoform 1 
FLJ37078              0.008   hypothetical protein LOC222183 
SYNJ1                 0.008   synaptojanin 1 isoform d 
MICALL1               0.008   molecule interacting with Rab13 
SYNJ1                 0.007   synaptojanin 1 isoform a 
RNF20                 0.007   ring finger protein 20 
MAP7                  0.007   microtubule-associated protein 7 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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