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Search of human proteins with 114520609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
(900 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114520609 neural precursor cell expressed, developmentally do... 1860 0.0
gi|114520607 neural precursor cell expressed, developmentally do... 1525 0.0
gi|21361472 neural precursor cell expressed, developmentally dow... 1218 0.0
gi|222352086 neural precursor cell expressed, developmentally do... 1214 0.0
gi|222352090 neural precursor cell expressed, developmentally do... 1208 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 1204 0.0
gi|222352094 neural precursor cell expressed, developmentally do... 1061 0.0
gi|222352092 neural precursor cell expressed, developmentally do... 1061 0.0
gi|222352183 neural precursor cell expressed, developmentally do... 1056 0.0
gi|222352084 neural precursor cell expressed, developmentally do... 1056 0.0
gi|222352082 neural precursor cell expressed, developmentally do... 1056 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 526 e-149
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 520 e-147
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 513 e-145
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 486 e-137
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 454 e-127
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 449 e-126
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 448 e-126
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 447 e-125
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 441 e-123
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 339 6e-93
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 282 9e-76
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 221 2e-57
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 201 2e-51
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 201 2e-51
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 201 2e-51
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 196 1e-49
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 184 2e-46
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 183 5e-46
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 183 5e-46
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 1860 bits (4817), Expect = 0.0
Identities = 900/900 (100%), Positives = 900/900 (100%)
Query: 1 MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ 60
MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ
Sbjct: 1 MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ 60
Query: 61 TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL 120
TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL
Sbjct: 61 TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL 120
Query: 121 ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA 180
ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA
Sbjct: 121 ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA 180
Query: 181 ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA 240
ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA
Sbjct: 181 ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA 240
Query: 241 QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEE 300
QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEE
Sbjct: 241 QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEE 300
Query: 301 LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE 360
LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE
Sbjct: 301 LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE 360
Query: 361 RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ 420
RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ
Sbjct: 361 RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ 420
Query: 421 GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE 480
GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE
Sbjct: 421 GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE 480
Query: 481 ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP 540
ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP
Sbjct: 481 ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP 540
Query: 541 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 600
NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM
Sbjct: 541 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 600
Query: 601 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 660
FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF
Sbjct: 601 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 660
Query: 661 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS 720
YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS
Sbjct: 661 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS 720
Query: 721 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 780
EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL
Sbjct: 721 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 780
Query: 781 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 840
GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE
Sbjct: 781 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 840
Query: 841 LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
Sbjct: 841 LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 1525 bits (3948), Expect = 0.0
Identities = 736/748 (98%), Positives = 738/748 (98%), Gaps = 4/748 (0%)
Query: 157 SEDDNAEQAEEL----EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH 212
S D N + EL +PGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH
Sbjct: 500 SRDSNRDCTNELSNSCKPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNH 559
Query: 213 ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED 272
ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED
Sbjct: 560 ESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIRED 619
Query: 273 EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY 332
EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY
Sbjct: 620 EATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAY 679
Query: 333 TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS 392
TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS
Sbjct: 680 TFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTS 739
Query: 393 SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 452
SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP
Sbjct: 740 SQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDP 799
Query: 453 RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT 512
RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT
Sbjct: 800 RLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT 859
Query: 513 GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR 572
GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR
Sbjct: 860 GPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKAR 919
Query: 573 LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL 632
LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL
Sbjct: 920 LWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHL 979
Query: 633 SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND 692
SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND
Sbjct: 980 SYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEND 1039
Query: 693 PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF 752
PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF
Sbjct: 1040 PTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAF 1099
Query: 753 KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV 812
KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV
Sbjct: 1100 KEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAV 1159
Query: 813 LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD 872
LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD
Sbjct: 1160 LMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLD 1219
Query: 873 LPPYESFEELWDKLQMAIENTQGFDGVD 900
LPPYESFEELWDKLQMAIENTQGFDGVD
Sbjct: 1220 LPPYESFEELWDKLQMAIENTQGFDGVD 1247
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 1218 bits (3152), Expect = 0.0
Identities = 617/948 (65%), Positives = 720/948 (75%), Gaps = 56/948 (5%)
Query: 8 VFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKK 66
V+GL EDE SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK
Sbjct: 9 VYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 68
Query: 67 SLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTF 126
+LNPKWNEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTF
Sbjct: 69 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 128
Query: 127 KDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQ 186
KDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q+
Sbjct: 129 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 188
Query: 187 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRA 243
+ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R
Sbjct: 189 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 248
Query: 244 FTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLA 298
F +RR ISE E E + + E WE I E+ + PPP ++ P L+
Sbjct: 249 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 308
Query: 299 EELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLLPTSSGLP 351
EEL+ RL I +S Q +S SSR S EQ LP + T+ GLP
Sbjct: 309 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP 368
Query: 352 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQSQASTSDS 408
GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ + S S
Sbjct: 369 SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLS 428
Query: 409 GQQVT---------------------------QPS---------EIEQGFLPKGWEVRHA 432
VT QPS ++ Q FLP GWE+R A
Sbjct: 429 SPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIA 488
Query: 433 PNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYI 492
PNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H DGR FYI
Sbjct: 489 PNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYI 547
Query: 493 NHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATV 552
+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEMKL R +
Sbjct: 548 DHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNI 607
Query: 553 LEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSA 612
E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSA
Sbjct: 608 FEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSA 667
Query: 613 TDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLH 672
TDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+
Sbjct: 668 TDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN 727
Query: 673 DMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEY 732
DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VTN+NK+EY
Sbjct: 728 DMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREY 787
Query: 733 IYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHT 792
I LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+
Sbjct: 788 IDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHS 847
Query: 793 KYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTV 852
YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+
Sbjct: 848 IYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTI 907
Query: 853 EQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 908 EQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 955
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 1214 bits (3141), Expect = 0.0
Identities = 615/968 (63%), Positives = 722/968 (74%), Gaps = 76/968 (7%)
Query: 8 VFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKK 66
V+GL EDE SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK
Sbjct: 9 VYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKK 68
Query: 67 SLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTF 126
+LNPKWNEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTF
Sbjct: 69 TLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTF 128
Query: 127 KDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQ 186
KDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q+
Sbjct: 129 KDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE 188
Query: 187 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRA 243
+ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R
Sbjct: 189 ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRR 248
Query: 244 FTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLA 298
F +RR ISE E E + + E WE I E+ + PPP ++ P L+
Sbjct: 249 FRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELS 308
Query: 299 EELNARLTIFGNS--------------------AVSQPASSSNH------SSRRGSLQAY 332
EEL+ RL I +S +V+ + H + R
Sbjct: 309 EELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTV 368
Query: 333 TFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLT 391
T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +
Sbjct: 369 TGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGS 428
Query: 392 SSQSS---AGPQSQASTSDSGQQVT---------------------------QPS----- 416
++ S+ PQ + S S VT QPS
Sbjct: 429 ATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSP 488
Query: 417 ----EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDL 472
++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDL
Sbjct: 489 KPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDL 547
Query: 473 GPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRK 532
GPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+K
Sbjct: 548 GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKK 607
Query: 533 LKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 592
LKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREW
Sbjct: 608 LKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREW 667
Query: 593 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 652
FFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLL
Sbjct: 668 FFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLL 727
Query: 653 DGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQ 712
DGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q
Sbjct: 728 DGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQ 787
Query: 713 HELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENE 772
+LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENE
Sbjct: 788 VDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENE 847
Query: 773 LELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSR 832
LELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSR
Sbjct: 848 LELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSR 907
Query: 833 VPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIEN 892
VPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN
Sbjct: 908 VPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVEN 967
Query: 893 TQGFDGVD 900
QGF+GVD
Sbjct: 968 AQGFEGVD 975
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 1208 bits (3125), Expect = 0.0
Identities = 611/942 (64%), Positives = 715/942 (75%), Gaps = 56/942 (5%)
Query: 14 DEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKKSLNPKW 72
++ SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK+LNPKW
Sbjct: 7 EQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKW 66
Query: 73 NEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLH 132
NEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTFKDF+L
Sbjct: 67 NEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLR 126
Query: 133 PRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSP 192
PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q++ P P
Sbjct: 127 PRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPP 186
Query: 193 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRAFTTRRQ 249
LPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R F +RR
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
Query: 250 ISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLAEELNAR 304
ISE E E + + E WE I E+ + PPP ++ P L+EEL+ R
Sbjct: 247 ISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRR 306
Query: 305 LTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLLPTSSGLPPGWEEK 357
L I +S Q +S SSR S EQ LP + T+ GLP GWEE+
Sbjct: 307 LQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEER 366
Query: 358 QDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQSQASTSDSGQQVT- 413
+D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ + S S VT
Sbjct: 367 KDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTL 426
Query: 414 --------------------------QPS---------EIEQGFLPKGWEVRHAPNGRPF 438
QPS ++ Q FLP GWE+R APNGRPF
Sbjct: 427 SAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPF 486
Query: 439 FIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKR 498
FIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H DGR FYI+HN K
Sbjct: 487 FIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKI 545
Query: 499 TQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYR 558
TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEMKL R + E+SYR
Sbjct: 546 TQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYR 605
Query: 559 RIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTL 618
RIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYYGLFEYSATDNYTL
Sbjct: 606 RIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTL 665
Query: 619 QINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVD 678
QINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML K ITL+DMESVD
Sbjct: 666 QINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVD 725
Query: 679 SEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738
SEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VTN+NK+EYI LVIQ
Sbjct: 726 SEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 785
Query: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 798
WRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDVNDWR+H+ YKNGY
Sbjct: 786 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGY 845
Query: 799 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTP 858
NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+P
Sbjct: 846 CPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSP 905
Query: 859 EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
EKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 906 EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 947
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 1204 bits (3114), Expect = 0.0
Identities = 609/962 (63%), Positives = 717/962 (74%), Gaps = 76/962 (7%)
Query: 14 DEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLY-DPMNGVLTSVQTKTIKKSLNPKW 72
++ SRI+RV+V++GI LAKKDI GASDPYV+++LY N L VQTKTIKK+LNPKW
Sbjct: 7 EQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKW 66
Query: 73 NEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLH 132
NEE FRV+P HRLLFEVFDENRLTRDDFLGQVDVPL LPTE+P +ERPYTFKDF+L
Sbjct: 67 NEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLR 126
Query: 133 PRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSP 192
PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D+A Q++ P P
Sbjct: 127 PRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPP 186
Query: 193 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ---AQRAFTTRRQ 249
LPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+ A R F +RR
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRH 246
Query: 250 ISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---LDVPTHLAEELNAR 304
ISE E E + + E WE I E+ + PPP ++ P L+EEL+ R
Sbjct: 247 ISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRR 306
Query: 305 LTIFGNS--------------------AVSQPASSSNH------SSRRGSLQAYTFEEQP 338
L I +S +V+ + H + R T E+P
Sbjct: 307 LQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEP 366
Query: 339 TLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS- 396
T V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+
Sbjct: 367 TPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNN 426
Query: 397 --AGPQSQASTSDSGQQVT---------------------------QPS---------EI 418
PQ + S S VT QPS ++
Sbjct: 427 HLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKV 486
Query: 419 EQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPG 478
Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPG
Sbjct: 487 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPG 545
Query: 479 WEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQND 538
WEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK D
Sbjct: 546 WEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 605
Query: 539 IPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISK 598
IPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SK
Sbjct: 606 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSK 665
Query: 599 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIR 658
EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIR
Sbjct: 666 EMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR 725
Query: 659 PFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNG 718
PFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK
Sbjct: 726 PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPN 785
Query: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMC 778
GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMC
Sbjct: 786 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMC 845
Query: 779 GLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGF 838
GLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGF
Sbjct: 846 GLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGF 905
Query: 839 AELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDG 898
AELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+G
Sbjct: 906 AELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEG 965
Query: 899 VD 900
VD
Sbjct: 966 VD 967
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1061 bits (2743), Expect = 0.0
Identities = 535/835 (64%), Positives = 627/835 (75%), Gaps = 55/835 (6%)
Query: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 292 DVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLL 344
P L+EEL+ RL I +S Q +S SSR S EQ LP +
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 345 PTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQS 401
T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 402 QASTSDSGQQVT---------------------------QPS---------EIEQGFLPK 425
+ S S VT QPS ++ Q FLP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 426 GWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHT 485
GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHL 419
Query: 486 DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEM 545
DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEM
Sbjct: 420 DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM 479
Query: 546 KLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYY 605
KL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYY
Sbjct: 480 KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY 539
Query: 606 GLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML 665
GLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML
Sbjct: 540 GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 599
Query: 666 HKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVT 725
K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VT
Sbjct: 600 GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 659
Query: 726 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 785
N+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDV
Sbjct: 660 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 719
Query: 786 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 845
NDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSN
Sbjct: 720 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 779
Query: 846 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
GPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 780 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 1061 bits (2743), Expect = 0.0
Identities = 535/835 (64%), Positives = 627/835 (75%), Gaps = 55/835 (6%)
Query: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 292 DVPTHLAEELNARLTIFGNSAVSQPAS--SSNHSSRRGSLQAY-TFEEQPTLP----VLL 344
P L+EEL+ RL I +S Q +S SSR S EQ LP +
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV 240
Query: 345 PTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSS---AGPQS 401
T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q + + +++ S+ PQ
Sbjct: 241 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI 300
Query: 402 QASTSDSGQQVT---------------------------QPS---------EIEQGFLPK 425
+ S S VT QPS ++ Q FLP
Sbjct: 301 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP 360
Query: 426 GWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHT 485
GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTSL+ NDLGPLPPGWEER H
Sbjct: 361 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNP-NDLGPLPPGWEERIHL 419
Query: 486 DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEM 545
DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+KY++FR+KLKK DIPN+FEM
Sbjct: 420 DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEM 479
Query: 546 KLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYY 605
KL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDYGGVAREWFFL+SKEMFNPYY
Sbjct: 480 KLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY 539
Query: 606 GLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML 665
GLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+AV+HGKLLDGFFIRPFYKMML
Sbjct: 540 GLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 599
Query: 666 HKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVT 725
K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE FGQT+Q +LK GSEI+VT
Sbjct: 600 GKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVT 659
Query: 726 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 785
N+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLIKIFDENELELLMCGLGDVDV
Sbjct: 660 NENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDV 719
Query: 786 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 845
NDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQFVTGTSRVPMNGFAELYGSN
Sbjct: 720 NDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN 779
Query: 846 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD 900
GPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +KL MA+EN QGF+GVD
Sbjct: 780 GPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD 834
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1056 bits (2732), Expect = 0.0
Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%)
Query: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325
P L+EEL+ RL I +S +V+ + H +
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384
R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414
+ + +++ S+ PQ + S S VT Q
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465
PS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525
L+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K
Sbjct: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479
Query: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585
Y++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDY
Sbjct: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539
Query: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645
GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A
Sbjct: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599
Query: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705
V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE
Sbjct: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659
Query: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765
FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI
Sbjct: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719
Query: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825
KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQ
Sbjct: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779
Query: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885
FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K
Sbjct: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839
Query: 886 LQMAIENTQGFDGVD 900
L MA+EN QGF+GVD
Sbjct: 840 LLMAVENAQGFEGVD 854
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1056 bits (2732), Expect = 0.0
Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%)
Query: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325
P L+EEL+ RL I +S +V+ + H +
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384
R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414
+ + +++ S+ PQ + S S VT Q
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465
PS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525
L+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K
Sbjct: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479
Query: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585
Y++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDY
Sbjct: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539
Query: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645
GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A
Sbjct: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599
Query: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705
V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE
Sbjct: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659
Query: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765
FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI
Sbjct: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719
Query: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825
KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQ
Sbjct: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779
Query: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885
FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K
Sbjct: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839
Query: 886 LQMAIENTQGFDGVD 900
L MA+EN QGF+GVD
Sbjct: 840 LLMAVENAQGFEGVD 854
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 1056 bits (2732), Expect = 0.0
Identities = 533/855 (62%), Positives = 629/855 (73%), Gaps = 75/855 (8%)
Query: 120 LERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPD 179
+ERPYTFKDF+L PRSHKSRVKG+LRLKM Y+PK G +++N++Q +++E GW V+D D
Sbjct: 1 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND 60
Query: 180 AACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQ 239
+A Q++ P PLPPGWEE+ D LGRTYYVNH +R TQW RP+ D ++++N Q+
Sbjct: 61 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN 120
Query: 240 ---AQRAFTTRRQISE--ETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSN---L 291
A R F +RR ISE E E + + E WE I E+ + PPP ++
Sbjct: 121 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR 180
Query: 292 DVPTHLAEELNARLTIFGNS--------------------AVSQPASSSNH------SSR 325
P L+EEL+ RL I +S +V+ + H +
Sbjct: 181 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG 240
Query: 326 RGSLQAYTFEEQPTLPVL-LPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT 384
R T E+PT V + T+ GLP GWEE++D +GR+YYV+HN+RTTTWT+P +Q
Sbjct: 241 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA 300
Query: 385 VETSQLTSSQSS---AGPQSQASTSDSGQQVT---------------------------Q 414
+ + +++ S+ PQ + S S VT Q
Sbjct: 301 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ 360
Query: 415 PS---------EIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTS 465
PS ++ Q FLP GWE+R APNGRPFFIDHNTKTTTWEDPRLK P H+R KTS
Sbjct: 361 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS 420
Query: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRK 525
L+ NDLGPLPPGWEER H DGR FYI+HN K TQWEDPRL+N AITGPAVPYSR++K+K
Sbjct: 421 LNP-NDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQK 479
Query: 526 YEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDY 585
Y++FR+KLKK DIPN+FEMKL R + E+SYRRIM VKR D LKARLWIEF+ EKGLDY
Sbjct: 480 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDY 539
Query: 586 GGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 645
GGVAREWFFL+SKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF FIGRVAG+A
Sbjct: 540 GGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLA 599
Query: 646 VYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEE 705
V+HGKLLDGFFIRPFYKMML K ITL+DMESVDSEYYNSL+WILENDPTELDL F IDEE
Sbjct: 600 VFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEE 659
Query: 706 LFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLI 765
FGQT+Q +LK GSEI+VTN+NK+EYI LVIQWRFVNR+QKQM AF EGF EL+P DLI
Sbjct: 660 NFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLI 719
Query: 766 KIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQ 825
KIFDENELELLMCGLGDVDVNDWR+H+ YKNGY NH VIQWFWKAVL+MD+EKRIRLLQ
Sbjct: 720 KIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQ 779
Query: 826 FVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDK 885
FVTGTSRVPMNGFAELYGSNGPQ FT+EQWG+PEKLPRAHTCFNRLDLPPYE+FE+L +K
Sbjct: 780 FVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREK 839
Query: 886 LQMAIENTQGFDGVD 900
L MA+EN QGF+GVD
Sbjct: 840 LLMAVENAQGFEGVD 854
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 526 bits (1356), Expect = e-149
Identities = 269/557 (48%), Positives = 364/557 (65%), Gaps = 26/557 (4%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--VETSQLTSSQSSAGPQSQASTSD 407
LPPGWE + D GR YYVDH +RTTTW +PT+++ E QL SQ Q
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFI 378
Query: 408 SGQQ----VTQPSEIEQ-GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRG 462
G Q +Q E + G LP GWE R NGR +F++HNT+ T WEDPR + L
Sbjct: 379 YGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ--GQLNE 436
Query: 463 KTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAI-TGPAVPYSRD 521
K PLP GWE R DG ++++HN + T + DPR A+ GP + Y RD
Sbjct: 437 K----------PLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRD 486
Query: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
+K K ++FR + Q +P ++ + R T+ EDS+++IM D L+ RLW+ F GE+
Sbjct: 487 FKAKVQYFRFWCQ-QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQD-LRRRLWVIFPGEE 544
Query: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
GLDYGGVAREWFFL+S E+ NP Y LFEY+ DNY LQINP S + N DHL YF+FIGR
Sbjct: 545 GLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRF 603
Query: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLR-- 699
MA++HGK +D F PFYK +L+KP+ L D+ES+D E+YNSL W+ EN+ E DL
Sbjct: 604 IAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMY 663
Query: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
F +D+E+ G+ H+LK G I+VT +NK+EYI +V +WR +++Q AF EGF E+
Sbjct: 664 FSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEI 723
Query: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
+PQ ++ FD ELE+L+CG+ ++D+NDW+ H Y++ Y+ + I WFW+ V +D+EK
Sbjct: 724 LPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YARTSKQIMWFWQFVKEIDNEK 782
Query: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
R+RLLQFVTGT R+P+ GFA+L GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 783 RMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSY 842
Query: 880 EELWDKLQMAIENTQGF 896
E+L +KL AIE T+GF
Sbjct: 843 EQLKEKLLFAIEETEGF 859
Score = 75.1 bits (183), Expect = 3e-13
Identities = 68/232 (29%), Positives = 96/232 (41%), Gaps = 44/232 (18%)
Query: 155 SGSEDDNAEQAEELEPGWVV-LDQPDAACHLQQQQE------PSPLPPGWEERQDILGRT 207
SG N L PGW +DQ ++ ++ P PLPPGWE R D +GR
Sbjct: 274 SGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRI 333
Query: 208 YYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWE 267
YYV+H +R T W+RPT +++ + E +Q R Q+ + + R N +
Sbjct: 334 YYVDHFTRTTTWQRPT-LESVRNYEQWQLQ---------RSQLQGAMQQFNQRFIYGNQD 383
Query: 268 IIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRG 327
+ AT S + P P + T + N R+ NH++R
Sbjct: 384 LF----ATSQSKEFDPLGPLPPGWEKRT----DSNGRVYFV------------NHNTR-- 421
Query: 328 SLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
T E P L LP GWE + G Y+VDHN RTTT+ P
Sbjct: 422 ----ITQWEDPRSQGQL-NEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
Score = 73.9 bits (180), Expect = 6e-13
Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 22/102 (21%)
Query: 408 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLD 467
SG + P + Q LP GWE R +GR +++DH K TTW+ P
Sbjct: 274 SGPRPLNP--VTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-------------- 317
Query: 468 TSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
PLPPGWE R GRI+Y++H + T W+ P LE+V
Sbjct: 318 ------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESV 353
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 520 bits (1338), Expect = e-147
Identities = 269/557 (48%), Positives = 367/557 (65%), Gaps = 31/557 (5%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
LPPGWE++ D RGR YYVDHN+RTTTW +PT + Q S ++ Q +
Sbjct: 332 LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 410 QQVTQPSEIEQ--GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR----LKIPAHLRGK 463
Q + S G LP GWE R NGR ++++HNT+TT WEDPR ++ PA
Sbjct: 392 YQSSSASTDHDPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPRTQGMIQEPA----- 445
Query: 464 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRD 521
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R
Sbjct: 446 -----------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRS 494
Query: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
++ KY FR L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+
Sbjct: 495 FRWKYHQFRF-LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEE 552
Query: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR
Sbjct: 553 GLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRF 611
Query: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 699
MA+YHGK +D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L
Sbjct: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
Query: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
FI D E+ G+ HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+
Sbjct: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
Query: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
P + ++ FDE ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EK
Sbjct: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEK 790
Query: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
RIRLLQFVTGT R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+
Sbjct: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850
Query: 880 EELWDKLQMAIENTQGF 896
E+L +KL AIE T+GF
Sbjct: 851 EQLREKLLYAIEETEGF 867
Score = 91.3 bits (225), Expect = 4e-18
Identities = 47/119 (39%), Positives = 58/119 (48%), Gaps = 22/119 (18%)
Query: 391 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 450
TS + A P S SG Q + LP GWE R PNGR +++DHNTKTTTWE
Sbjct: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
Query: 451 DPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
PLPPGWE+RT GR +Y++HN + T W+ P E V
Sbjct: 330 ----------------------RPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV 366
Score = 79.3 bits (194), Expect = 1e-14
Identities = 68/241 (28%), Positives = 96/241 (39%), Gaps = 62/241 (25%)
Query: 152 PKTSGSED--DNAEQAEELEPGWVVLDQPDAACHLQQQQEPS-----PLPPGWEERQDIL 204
P TSG++ A+ + L GW + P+ + + PLPPGWE+R D
Sbjct: 284 PSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPR 343
Query: 205 GRTYYVNHESRRTQWKRPTPQ--DNLTDAENGNIQLQ-AQRAFTTRRQISEETESVDNRE 261
GR YYV+H +R T W+RPT + N ++ QLQ A + F+ R + S D+
Sbjct: 344 GRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDP 403
Query: 262 SS---ENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPAS 318
WE R+D +Y
Sbjct: 404 LGPLPPGWE-KRQDNGRVY----------------------------------------- 421
Query: 319 SSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTK 378
NH++R T E P ++ LPPGWE K G Y+VDHN+RTTT+
Sbjct: 422 YVNHNTRT------TQWEDPRTQGMI-QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKD 474
Query: 379 P 379
P
Sbjct: 475 P 475
Score = 39.3 bits (90), Expect = 0.017
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 224
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 442 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 513 bits (1321), Expect = e-145
Identities = 263/557 (47%), Positives = 368/557 (66%), Gaps = 30/557 (5%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
LPPGWE + D+R R YYVDHN+RTTTW +PT+++ Q S ++ Q Q +
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRN----QLQGAMQQFN 438
Query: 410 QQVTQPSEI------EQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGK 463
Q+ + + G LP GWE R R +F++HNTKTT WEDPR +
Sbjct: 439 QRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ-------- 490
Query: 464 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT--GPAVPYSRD 521
N+ PLP GWE R +G ++++HN + T ++DPR ++T GP + Y R
Sbjct: 491 ---GLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERG 546
Query: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
++ K FR L + N +P+ ++ + R T+ EDS+++IM +K D L+ RL++ F GE+
Sbjct: 547 FRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEE 604
Query: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHLSYF FIGR
Sbjct: 605 GLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRF 663
Query: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 699
MA++HGK +D F PFYK ML K +T+ D+ES+D+E+YNSL WI +N+ E L++
Sbjct: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
Query: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
F +D E+ G+ H+LK GGS I+VT +NK EYI L+ +WRF +Q+Q AF +GF E+
Sbjct: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
Query: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
+P ++ FDE ELE+++CG+ +VD+ DW+ +T Y++ Y+ N + I WFW+ V D+E
Sbjct: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEV 842
Query: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
R+RLLQFVTGT R+P+ GFAEL GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 843 RMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY 902
Query: 880 EELWDKLQMAIENTQGF 896
E+L +KL AIE T+GF
Sbjct: 903 EQLKEKLLFAIEETEGF 919
Score = 90.9 bits (224), Expect = 5e-18
Identities = 71/274 (25%), Positives = 112/274 (40%), Gaps = 38/274 (13%)
Query: 243 AFTTRRQISEETESVDNR-------ESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPT 295
A TT R E T +DN ++S ++ D +Q P N P
Sbjct: 175 ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARP---KNTPAPK 231
Query: 296 HLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWE 355
LA E A T+ G S+ P +++ + EE P T+ PP E
Sbjct: 232 PLASE-PADDTVNGESSSFAPTDNASVTGT-----PVVSEENALSPNCTSTTVEDPPVQE 285
Query: 356 EKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQP 415
++ + + ++ S+ +S+ +A + D +Q +
Sbjct: 286 ILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGN 345
Query: 416 SEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPL 475
+ E LP GWE R P+GR +++DHNT+TTTWE P+ PL
Sbjct: 346 ANTET--LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------------PL 383
Query: 476 PPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
PPGWE R R++Y++HN + T W+ P +E+V
Sbjct: 384 PPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESV 417
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/265 (26%), Positives = 100/265 (37%), Gaps = 62/265 (23%)
Query: 130 VLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQA-----EELEPGWVVLDQPDAACHL 184
+L P + SR + P G D +Q+ E L GW P +
Sbjct: 310 ILEPDTSNSRSSSAFEAAKSRQP--DGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYY 367
Query: 185 QQQ-------QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQD--NLTDAENGN 235
+ P PLPPGWE R D R YYV+H +R T W+RPT + N ++
Sbjct: 368 VDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQR 427
Query: 236 IQLQ-AQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVP 294
QLQ A + F R S A+M + + P P +P
Sbjct: 428 NQLQGAMQQFNQRYLYS----------------------ASMLAAENDPYGP------LP 459
Query: 295 THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGW 354
+ +++ ++ NH+++ T E P L LP GW
Sbjct: 460 PGWEKRVDSTDRVY----------FVNHNTKT------TQWEDPRTQGL-QNEEPLPEGW 502
Query: 355 EEKQDERGRSYYVDHNSRTTTWTKP 379
E + G Y+VDHN+RTTT+ P
Sbjct: 503 EIRYTREGVRYFVDHNTRTTTFKDP 527
Score = 39.7 bits (91), Expect = 0.013
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 185 QQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAF 244
Q Q PLP GWE R G Y+V+H +R T +K P++ + G Q+ +R F
Sbjct: 490 QGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFK--DPRNGKSSVTKGGPQIAYERGF 547
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 486 bits (1252), Expect = e-137
Identities = 266/597 (44%), Positives = 362/597 (60%), Gaps = 60/597 (10%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQ---LTSSQSSAGPQSQASTS 406
LP GWEE++ GR Y++H +RTT W +PT A+ +S L+ P S + +
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
Query: 407 DSGQQVTQPSEIEQGF-------------------LPKGWEVRHAPNGRPFFIDHNTKTT 447
GQ + P E+ LP+G+E R G+ +F+ T +
Sbjct: 219 TCGQS-SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVS 277
Query: 448 TWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL- 506
TW DPR +P L S +LGPLPPGWE R GR+++++HN + TQ+ DPRL
Sbjct: 278 TWHDPR--VPRDL----SNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331
Query: 507 ------------------ENVAITGP------AVP-YSRDYKRKYEFFRRKLKKQNDIPN 541
+ V P VP Y RD +K + R++L +Q
Sbjct: 332 ANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAG 391
Query: 542 KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF 601
+++ R + E+SYR++M ++ D K RL I+F GE+GLDYGGVAREW +L+S EM
Sbjct: 392 HCRIEVSREEIFEESYRQVMKMRPKDLWK-RLMIKFRGEEGLDYGGVAREWLYLLSHEML 450
Query: 602 NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY 661
NPYYGLF+YS D YTLQINP+S + N +HLSYF F+GR+ GMAV+HG +DG F PFY
Sbjct: 451 NPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY 509
Query: 662 KMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGS 720
K +L K ITL DME VD + +NSL WILEND T LD F ++ +G+ QHELK G
Sbjct: 510 KQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGK 569
Query: 721 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 780
I V +NKKEY+ L + WRF+ I+ Q A ++GF E+IPQ L+K FDE ELEL++CGL
Sbjct: 570 SIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGL 629
Query: 781 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 840
G +DVNDW+ +T+ K+ + + +++WFWKAV D E+R RLLQFVTG+SRVP+ GF
Sbjct: 630 GKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKA 688
Query: 841 LYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
L G+ GP+ FT+ Q LP+AHTCFNR+D+PPYES+E+L++KL AIE T GF
Sbjct: 689 LQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745
Score = 80.5 bits (197), Expect = 7e-15
Identities = 88/368 (23%), Positives = 140/368 (38%), Gaps = 50/368 (13%)
Query: 21 VRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRV 80
+R+ V+ L KKD DP+ +V + +G T T+K +L+PKWN+ +
Sbjct: 14 LRLTVLCAKNLVKKDFFRLPDPFAKVVV----DGSGQCHSTDTVKNTLDPKWNQHYDLYI 69
Query: 81 HPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRV 140
+ + V++ ++ + G + N + Y D + V
Sbjct: 70 G-KSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTV 128
Query: 141 KGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEER 200
+G + + + + + + G V+D C + + LP GWEER
Sbjct: 129 RGQIVVSL--------------QSRDRIGTGGQVVD-----C---SRLFDNDLPDGWEER 166
Query: 201 QDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNR 260
+ GR Y+NH +R TQW+RPT A + + F T
Sbjct: 167 RTASGRIQYLNHITRTTQWERPT-----RPASEYSSPGRPLSCFVDENTPISGTNGATCG 221
Query: 261 ESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAV--SQPAS 318
+SS+ R + + N ++L P L E R T G +Q
Sbjct: 222 QSSDPRLAERRVRSQRHRNYM-----SRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGV 276
Query: 319 SSNHSSR-RGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWT 377
S+ H R L EE LPPGWE + GR Y+VDHN+RTT +T
Sbjct: 277 STWHDPRVPRDLSNINCEE----------LGPLPPGWEIRNTATGRVYFVDHNNRTTQFT 326
Query: 378 KPTVQATV 385
P + A +
Sbjct: 327 DPRLSANL 334
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 48/144 (33%)
Query: 408 SGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE----------------- 450
+G QV S + LP GWE R +GR +++H T+TT WE
Sbjct: 144 TGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLS 203
Query: 451 ---------------------DPRL-------KIPAHLRGKTSLDTSNDLGPLPPGWEER 482
DPRL + + +T L T D LP G+E+R
Sbjct: 204 CFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPD---LPEGYEQR 260
Query: 483 THTDGRIFYINHNIKRTQWEDPRL 506
T G++++++ + W DPR+
Sbjct: 261 TTQQGQVYFLHTQTGVSTWHDPRV 284
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR 247
+E PLPPGWE R GR Y+V+H +R TQ+ P NL N QL+ Q+
Sbjct: 294 EELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVV 353
Query: 248 RQISEETESVD----NRESSENWEIIRED 272
++TE + R+ + +I+R++
Sbjct: 354 SLCPDDTECLTVPRYKRDLVQKLKILRQE 382
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 454 bits (1167), Expect = e-127
Identities = 282/771 (36%), Positives = 400/771 (51%), Gaps = 65/771 (8%)
Query: 187 QQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPT----PQ-----DNLTDAENGNIQ 237
Q+ LPP WE R D GR +YV+H +R T W+RPT PQ +++ E N +
Sbjct: 803 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR 862
Query: 238 LQAQRAFTTRRQISEETESVDNRESSENWEIIRED--------EATMYSN-QAFPSPPPS 288
Q+ R T + E T ++D ++ D +T S PP
Sbjct: 863 YQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPV 922
Query: 289 SNLDVP---THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLP 345
L P T L +A N+ + + + + + L +
Sbjct: 923 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN 982
Query: 346 TSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--------QATVETSQLTSSQSS- 396
LP GWE K D +G++++VDHNSRTTT+ P + A V LT +S
Sbjct: 983 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS 1042
Query: 397 ----------AGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVR-----HAPNGRPFFID 441
AGP S + V++P Q +P + + PN +
Sbjct: 1043 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQY--QDMVPVAYNDKIVAFLRQPNIFEILQE 1100
Query: 442 HNTKTTTWEDPRLKIP----AHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINH--- 494
T R KI G L + DL L +EE + + H
Sbjct: 1101 RQPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSY 1160
Query: 495 ------NIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKL--KKQNDIPNKFEMK 546
+ + P + PA PY RD++ K F RKL K P K ++
Sbjct: 1161 CQSPRGSPVSSPQNSPGTQRANARAPA-PYKRDFEAKLRNFYRKLETKGYGQGPGKLKLI 1219
Query: 547 LRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYG 606
+RR +LED++ +IMG R D + +L++ F GE+GLDY G +RE+FFL+S+E+FNPYYG
Sbjct: 1220 IRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYG 1279
Query: 607 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLH 666
LFEYSA D YT+QI+P S + H +F+F GR+ G+A+ H LLD FF RPFYK +L
Sbjct: 1280 LFEYSANDTYTVQISPMSAFVDNHH-EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR 1338
Query: 667 KPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVT 725
L D+E +D E++ SL+W+ +ND + LDL F ++EE+FGQ + ELK GG+ I VT
Sbjct: 1339 ILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVT 1398
Query: 726 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 785
KNKKEYI +++WR + +Q + GF+E++ L+ +FD ELEL++ G ++D+
Sbjct: 1399 EKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDL 1458
Query: 786 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN 845
+DWR +T+Y+ GY NH VI+WFW AV ++E+R+RLLQFVTGTS +P GFA L GSN
Sbjct: 1459 SDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN 1518
Query: 846 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
GP+ F VE+WG LPRAHTCFNRLDLPPY SF L++KL A+E T F
Sbjct: 1519 GPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1569
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 383 ATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDH 442
AT + T + G Q S Q V++ +++ LP WE R +GR F++DH
Sbjct: 770 ATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEA-LPPNWEARIDSHGRIFYVDH 828
Query: 443 NTKTTTWEDP 452
+TTTW+ P
Sbjct: 829 VNRTTTWQRP 838
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 449 bits (1155), Expect = e-126
Identities = 233/502 (46%), Positives = 322/502 (64%), Gaps = 37/502 (7%)
Query: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
LP+G+E R G+ +F+ T +TW DPR IP L ++LGPLPPGWE R
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR--IPRDLNSVNC----DELGPLPPGWEVR 289
Query: 483 THTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP------------------YS 519
+ GRI++++HN + TQ+ DPRL ++ + P+ P Y
Sbjct: 290 STVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYE 349
Query: 520 RDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDG 579
RD +K + R +L Q +++ R + E+SYR+IM ++ D LK RL ++F G
Sbjct: 350 RDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKD-LKKRLMVKFRG 408
Query: 580 EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIG 639
E+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQINP+S + N DHLSYF F+G
Sbjct: 409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVG 467
Query: 640 RVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDL 698
R+ G+AV+HG ++G F PFYK +L KPI L D+ESVD E + SL WILEND T LD
Sbjct: 468 RIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDH 527
Query: 699 RFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE 758
F ++ FG+ QHELK G + VT +NKKEY+ L + WRF+ I+ Q A ++GF E
Sbjct: 528 TFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNE 587
Query: 759 LIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE 818
LIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+ A+ +++WFW+AV D E
Sbjct: 588 LIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEE 646
Query: 819 KRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW-GTPEKLPRAHTCFNRLDLP 874
+R RLLQFVTG++RVP+ GF L GS GP+ FT+ + LP+AHTCFNR+D+P
Sbjct: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
Query: 875 PYESFEELWDKLQMAIENTQGF 896
PYES+E+L++KL A+E T GF
Sbjct: 707 PYESYEKLYEKLLTAVEETCGF 728
Score = 45.4 bits (106), Expect = 2e-04
Identities = 18/30 (60%), Positives = 22/30 (73%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
LPPGWE + GR Y+VDHN+RTT +T P
Sbjct: 282 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
Score = 45.1 bits (105), Expect = 3e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 189 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 278 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
Score = 38.5 bits (88), Expect = 0.028
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 21 VRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNE 74
+R+ V+ LAKKD DP+ ++ + +G T T+K +L+PKWN+
Sbjct: 15 IRLTVLCAKNLAKKDFFRLPDPFAKIVV----DGSGQCHSTDTVKNTLDPKWNQ 64
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 448 bits (1153), Expect = e-126
Identities = 237/522 (45%), Positives = 330/522 (63%), Gaps = 51/522 (9%)
Query: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAH--------------LRGKTS--- 465
LP+G+E R G+ +F+ T +TW DPR+ P+ L+G TS
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPR 295
Query: 466 -LDTSN--DLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVA-----ITGPAVP 517
L++ N +LGPLPPGWE R+ GRI++++HN + TQ+ DPRL ++ + P+ P
Sbjct: 296 DLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQP 355
Query: 518 ------------------YSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRR 559
Y RD +K + R +L Q +++ R + E+SYR+
Sbjct: 356 LPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQ 415
Query: 560 IMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQ 619
IM ++ D LK RL ++F GE+GLDYGGVAREW +L+ EM NPYYGLF+YS + Y LQ
Sbjct: 416 IMKMRPKD-LKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQ 474
Query: 620 INPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDS 679
INP+S + N DHLSYF F+GR+ G+AV+HG ++G F PFYK +L KPI L D+ESVD
Sbjct: 475 INPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDP 533
Query: 680 EYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738
E + SL WILEND T LD F ++ FG+ QHELK G + VT +NKKEY+ L +
Sbjct: 534 ELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
Query: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 798
WRF+ I+ Q A ++GF ELIPQ L+K FD+ ELEL++ GL +D+NDW+ +T+ K+
Sbjct: 594 WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-C 652
Query: 799 SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSN---GPQSFTVEQW 855
A+ +++WFW+AV D E+R RLLQFVTG++RVP+ GF L GS GP+ FT+
Sbjct: 653 VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLI 712
Query: 856 -GTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
+ LP+AHTCFNR+D+PPYES+E+L++KL A+E T GF
Sbjct: 713 DANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754
Score = 45.1 bits (105), Expect = 3e-04
Identities = 18/34 (52%), Positives = 23/34 (67%)
Query: 189 EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
E PLPPGWE R + GR Y+V+H +R TQ+ P
Sbjct: 304 ELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
Score = 38.5 bits (88), Expect = 0.028
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 21 VRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNE 74
+R+ V+ LAKKD DP+ ++ + +G T T+K +L+PKWN+
Sbjct: 15 IRLTVLCAKNLAKKDFFRLPDPFAKIVV----DGSGQCHSTDTVKNTLDPKWNQ 64
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 447 bits (1149), Expect = e-125
Identities = 277/777 (35%), Positives = 407/777 (52%), Gaps = 75/777 (9%)
Query: 192 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAE-NGNIQLQAQ---RAFTTR 247
PLPP WE R D GR +YV+H +R T W+RPT +G+IQ Q R +
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQ 889
Query: 248 RQISEETESVDN----------------------RESSENWEIIREDEATMYSNQAF--- 282
R I+ E D+ S + ++ RE + ++Q
Sbjct: 890 RTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLL 949
Query: 283 ---PSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPT 339
P+ +N + T L +A ++ + +R + +
Sbjct: 950 LQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNF 1009
Query: 340 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--QATVETSQLTSSQS-- 395
+ + T LP GWE K D++G+S++VDHNSR TT+ P + Q + LT Q
Sbjct: 1010 INMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQ 1069
Query: 396 -----SAGPQSQASTSDSGQQVTQP---------SEIEQGFLPKGWEVR-----HAPNGR 436
SAG S+ S + + +P S+ + LP + + PN
Sbjct: 1070 RLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIF 1129
Query: 437 PFFIDHNTKTTTWEDPRLKIPAHLR-----GKTSLDTSNDLGPLPPGWEERTHT------ 485
+ R KI ++R G L DL L +EE +
Sbjct: 1130 EMLQERQPSLARNHTLREKIH-YIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQA 1188
Query: 486 ---DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN--DIP 540
G F + + P L+ + P+ PY RD++ K F RKL+ + P
Sbjct: 1189 AFHPGYSFSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGP 1247
Query: 541 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 600
K ++ +RR +LE ++ ++M R + + +L++ F GE+GLDY G +RE+FFL+S+E+
Sbjct: 1248 GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
Query: 601 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 660
FNPYYGLFEYSA D YT+QI+P S E+HL +F+F GR+ G+A+ H LLD FF RPF
Sbjct: 1308 FNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPF 1366
Query: 661 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGG 719
YK +L P L D+E +D E++ SL+W+ +N+ T+ LDL F ++EE+FGQ + ELK+GG
Sbjct: 1367 YKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGG 1426
Query: 720 SEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG 779
+ VT KNKKEYI +++WR + +Q A GF+E++ L+ +FD ELEL++ G
Sbjct: 1427 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAG 1486
Query: 780 LGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFA 839
++D+NDWR +T+Y+ GY H VI+WFW AV ++E+R+RLLQFVTGTS VP GFA
Sbjct: 1487 TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1546
Query: 840 ELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
L GSNG + F +E+WG LPRAHTCFNRLDLPPY S+ L++KL A+E T F
Sbjct: 1547 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Score = 65.1 bits (157), Expect = 3e-10
Identities = 83/339 (24%), Positives = 118/339 (34%), Gaps = 96/339 (28%)
Query: 256 SVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQ 315
SVD+ + SE+ +D+ N AF S P S + EL+ T +
Sbjct: 721 SVDSAKISESTVFSSQDDEEE-ENSAFESVPDSMQ-------SPELDPESTNGAGPWQDE 772
Query: 316 PASSSNH---------------SSRRGSLQAYTFEEQPT--LPVLLPT-------SSGLP 351
A+ S H S+RR QP LP L P LP
Sbjct: 773 LAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
Query: 352 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--------------------------- 384
P WE + D GR +YVDH +RTTTW +PT AT
Sbjct: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTI 892
Query: 385 -VETSQLTSSQSS-----------AGPQSQASTSDSGQQVTQPSEIEQ------GFLPKG 426
E S+ S S G S+A +S S + + + L +
Sbjct: 893 ATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQS 952
Query: 427 WEVRHAPNGRPFFIDHN--------TKTTTWEDPRLKIPAHLRGKTSLDTSNDLG----- 473
V+ N F + H T +T + LK+ R + DL
Sbjct: 953 PAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINM 1012
Query: 474 ------PLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL 506
LP GWE +T G+ F+++HN + T + DPR+
Sbjct: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 441 bits (1133), Expect = e-123
Identities = 219/426 (51%), Positives = 301/426 (70%), Gaps = 8/426 (1%)
Query: 475 LPPGWEERTHTDGRIFYINHNIKRTQWEDPR--LENVAITGPAVPYSRDYKRKYEFFRRK 532
LPPGWE + ++G ++++HN + T ++DPR E+ G Y R ++ KY FR
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRF- 65
Query: 533 LKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 592
L N +P+ ++ + R T+ EDS+++IM +K D L+ RL+I GE+GLDYGG+AREW
Sbjct: 66 LCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYD-LRRRLYIIMRGEEGLDYGGIAREW 124
Query: 593 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLL 652
FFL+S E+ NP Y LFEY+ +NY LQINP S + N DHL+YF+FIGR MA+YHGK +
Sbjct: 125 FFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 653 DGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLRFIIDEELFGQT 710
D F PFYK ML+K TL D+ES+D E+YNS+ WI EN+ E L+L FI D E+ G+
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 711 HQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDE 770
HELK GG I VT +NK+EYI L+ WRF +++Q AF +GF E+ P + ++ FDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 771 NELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGT 830
ELEL++CG+ ++D++DW++ T Y++ Y+ N + IQWFW+ V MD+EKRIRLLQFVTGT
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 831 SRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890
R+P+ GFAEL GSNGPQ F +++ G LPR+HTCFNRLDLPPY+S+E+L +KL AI
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAI 422
Query: 891 ENTQGF 896
E T+GF
Sbjct: 423 EETEGF 428
Score = 44.7 bits (104), Expect = 4e-04
Identities = 18/30 (60%), Positives = 21/30 (70%)
Query: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379
LPPGWE K G Y+VDHN+RTTT+ P
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
Score = 39.3 bits (90), Expect = 0.017
Identities = 18/37 (48%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 188 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 224
QEP+ LPPGWE + G Y+V+H +R T +K P P
Sbjct: 3 QEPA-LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 339 bits (870), Expect = 6e-93
Identities = 186/382 (48%), Positives = 254/382 (66%), Gaps = 11/382 (2%)
Query: 521 DYKRKYEFFRRKLKKQNDIPNKFEMKL--RRATVLEDSYRRIMGVKRADFLKARLWIEFD 578
D KRKY FR++L++ ++ K +M + RR V EDSYR + K + +K RL+I F+
Sbjct: 3995 DVKRKY--FRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHR-KSPEEMKNRLYIVFE 4051
Query: 579 GEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFI 638
GE+G D GG+ REW+ +IS+EMFNP Y LF S D T INP+S CN +HLSYFKF+
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH-CNPNHLSYFKFV 4110
Query: 639 GRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTEL-- 696
GR+ AVY +LL+ +F R FYK +L K + DMES D +Y L ++LEND + L
Sbjct: 4111 GRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGY 4170
Query: 697 DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGF 756
DL F + + FG +LK G+ I+VT +NKKEY++LV Q R I+KQ+AAF EGF
Sbjct: 4171 DLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGF 4230
Query: 757 FELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMD 816
+E+IP+ LI IF E ELELL+ GL +D++D + +T+Y + Y +N IQWFW+A+ D
Sbjct: 4231 YEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFD 4289
Query: 817 SEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAHTCFNRLDLPP 875
R + LQFVTGTS+VP+ GFA L G NG Q F + + + ++LP AHTCFN+LDLP
Sbjct: 4290 QADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4349
Query: 876 YESFEELWDKLQMAI-ENTQGF 896
YESFE+L L +AI E ++GF
Sbjct: 4350 YESFEKLRHMLLLAIQECSEGF 4371
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 282 bits (722), Expect = 9e-76
Identities = 149/325 (45%), Positives = 211/325 (64%), Gaps = 6/325 (1%)
Query: 569 LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCN 628
LK + + F GE+G+ G V REWF ++S E+ NP Y LF SA D T Q N NS + N
Sbjct: 578 LKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-N 634
Query: 629 EDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWI 688
DHL+YF+F G++ G+A+ H +L++ +F R FYK +L P+ D+ S+D EY +L+WI
Sbjct: 635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI 694
Query: 689 LENDPTEL--DLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQ 746
L+ND ++L +L F ++ ++FG + LK GG I+VT NK EY+ LV + R IQ
Sbjct: 695 LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQ 754
Query: 747 KQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQ 806
Q+ AF +GF IP LI++FDE ELELL+ G+ ++DV+DW ++T+Y +GY VIQ
Sbjct: 755 PQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQ 814
Query: 807 WFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWG-TPEKLPRAH 865
WFW+ V + E+R+ LLQFVTG+SRVP GFA + G +G Q+FT+ TP LP +
Sbjct: 815 WFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSS 874
Query: 866 TCFNRLDLPPYESFEELWDKLQMAI 890
TC N L LP Y S E L D+L +A+
Sbjct: 875 TCINMLKLPEYPSKEILKDRLLVAL 899
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 221 bits (563), Expect = 2e-57
Identities = 141/394 (35%), Positives = 218/394 (55%), Gaps = 25/394 (6%)
Query: 519 SRDYKRKYEFFRRKLKK--QNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 576
S ++ K FF+R+L++ +K +K+ R +LE S + +D+ K +
Sbjct: 436 SETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVV 494
Query: 577 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 636
F E+ LD+GG REWF LI K +F+ LF + +N L ++PN L ++
Sbjct: 495 FQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLKMYE 553
Query: 637 FIGRVAGMAVYHGKLLDGF-------FIRPFYKMMLHKPITLHDMESVDSEYYNS-LRWI 688
F GR+ G +Y L + F R F ++ + E+ D E+Y S + +I
Sbjct: 554 FAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFI 613
Query: 689 LENDPTELDLRFIIDEELFGQTHQH----ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNR 744
L ND +E++L F EE + ++ Q EL GG++ VTN NK Y+ L+ Q+R ++
Sbjct: 614 LNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQ 671
Query: 745 IQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNG-YSANHQ 803
+++++ F +G EL+P++L+ IFDENELELLMCG GD+ V+D++ H G + +
Sbjct: 672 VKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREK 731
Query: 804 VIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPR 863
V++WFW V + E+ RLLQF TG+S++P GFA L SF + T LP
Sbjct: 732 VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALC-----PSFQIIAAPTHSTLPT 786
Query: 864 AHTCFNRLDLPPYESFEELWDKLQMAI-ENTQGF 896
AHTCFN+L LP Y+S+EE+ LQ+AI E +GF
Sbjct: 787 AHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 201 bits (512), Expect = 2e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
Query: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 582 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
Query: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
Query: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
Query: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
Query: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 817 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
Query: 895 GF 896
GF
Sbjct: 868 GF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 201 bits (512), Expect = 2e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561
Query: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 562 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 616
Query: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 617 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 676
Query: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 677 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 736
Query: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 737 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 796
Query: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 797 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 847
Query: 895 GF 896
GF
Sbjct: 848 GF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 201 bits (512), Expect = 2e-51
Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)
Query: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602
+K+RR +++D+ R+ + ++ LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584
Query: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662
P G+F Y + NP+S + F IG V G+A+Y+ +LD F Y+
Sbjct: 585 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 639
Query: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718
++ K T D+ Y SL+ +LE N ++ + F I + +LFG ++LK
Sbjct: 640 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 699
Query: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777
G +I +TN+N+KE++ L + ++KQ AF+ GF + + +K +F E+ELL+
Sbjct: 700 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 759
Query: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837
CG ++D E T+Y GY+ + +I+ FW+ V E++ LQF TGT R P+ G
Sbjct: 760 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 819
Query: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894
+L NGP + E+LP +HTCFN L LP Y S E+L ++L AI +
Sbjct: 820 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 870
Query: 895 GF 896
GF
Sbjct: 871 GF 872
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 196 bits (497), Expect = 1e-49
Identities = 130/370 (35%), Positives = 202/370 (54%), Gaps = 33/370 (8%)
Query: 545 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 604
MK+RR ++ DS + KRAD LK +L + F GE GLD GG+ +EWF L+ +++F+P
Sbjct: 419 MKVRRTHLVSDSLDELTR-KRAD-LKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPD 476
Query: 605 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 664
YG+F Y D++ + S C D+ S F+ +G + G+AVY+ LD F YK +
Sbjct: 477 YGMFTYHK-DSHCHWFS--SFKC--DNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 665 LHKPI--------------TLHDMESVDSEYYNSLRWILENDPT---ELDLRFIIDEELF 707
L PI T+ D+ + E + L +L ++ + F + +E F
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEF 591
Query: 708 GQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKI 767
G + LK GG +I VTN+N+KEY+ L + I KQ AAF GF + + + +
Sbjct: 592 GIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALML 651
Query: 768 FDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFV 827
E+E+L+CG D+D++ + T+Y +GY+ I++FW VL + + +LL F
Sbjct: 652 LRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFT 710
Query: 828 TGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKL 886
TG+ RVP+ G A+L +F + + T LP AHTCFN+L LPPY+S ++L KL
Sbjct: 711 TGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKL 763
Query: 887 QMAIENTQGF 896
+ I N++GF
Sbjct: 764 IIGISNSEGF 773
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 184 bits (468), Expect = 2e-46
Identities = 127/401 (31%), Positives = 209/401 (52%), Gaps = 27/401 (6%)
Query: 516 VPYSRDYKRKYEFFRR-----KLKKQNDIP--NKFEMKLRRATVLEDSYRRIMGVKRADF 568
+P+ ++ + + F+R K + Q D P + + +RR + ED+Y ++ D
Sbjct: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
Query: 569 LKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPN 623
LK R+ + E G+D GG+ RE+ + K FNP G F+ T+ L NP
Sbjct: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
Query: 624 SGLCNEDHLS-YFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPITLHDMESVDSE 680
+ + D + ++ F+GR+ G A+Y L++ F F +L + +H + S+D E
Sbjct: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
Query: 681 YYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738
Y +L ++ E+D EL L F + G+ ELK GG +I VT+ N+ YI+LV
Sbjct: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Query: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG-DVDVNDWREHTKYKNG 797
+R +I++ AF++G ++ + +++FD+ E+++L+ G + + D + T Y G
Sbjct: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
Query: 798 YSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT 857
YSA+H VI+ FW+ V E++ +LL+FVT SR P+ GF ELY +F + G+
Sbjct: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY-----PAFCIHNGGS 1040
Query: 858 P-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 897
E+LP A TC N L LP + L KL AIE GF+
Sbjct: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 183 bits (465), Expect = 5e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 516 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 565
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
Query: 566 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 620
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
Query: 621 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 675
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
Query: 676 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 733
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
Query: 734 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 792
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
Query: 793 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 841
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Query: 842 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
Query: 891 ENTQGFD 897
GF+
Sbjct: 1060 SMNTGFE 1066
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 183 bits (465), Expect = 5e-46
Identities = 134/427 (31%), Positives = 218/427 (51%), Gaps = 49/427 (11%)
Query: 516 VPYSRDYKRKYEFFRRKLKKQND----------IPNKFEMKLRRATVLEDSYRRIMGVKR 565
+P+ +K + FR + K+ + P+ + +RR+ +LED Y ++ + +
Sbjct: 644 IPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQ 703
Query: 566 ADFLKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQI 620
+K + ++F E G+D GV +E+ I K +F+P LF+ ++ D L
Sbjct: 704 -HAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDE-RLYP 761
Query: 621 NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPI---TLHDME 675
+P S + +E++L F+F+G++ G AVY G ++D F F +L H + ++ ++
Sbjct: 762 SPTSYI-HENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELP 820
Query: 676 SVDSEYYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYI 733
S+DSE+Y +L I + D T+L L DE++ GQ HEL GG I VTN+NK YI
Sbjct: 821 SLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYI 880
Query: 734 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG-LGDVDVNDWREHT 792
+L+ +R +I+ Q AA GF +I + I++F EL+ L+ G ++D+ D ++HT
Sbjct: 881 HLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHT 940
Query: 793 KYKNGYSANHQVIQWFWKAVLMMD--SEKRIRLLQFVTGTSRVPMNGFAEL--------- 841
Y G+ +H+VI W W +L D ++R L+FVT SR P+ GFA L
Sbjct: 941 VYYGGFHGSHRVIIWLWD-ILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCV 999
Query: 842 -----------YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAI 890
GS FT+ + +LP + TCFN L LP Y L +KL+ AI
Sbjct: 1000 EVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059
Query: 891 ENTQGFD 897
GF+
Sbjct: 1060 SMNTGFE 1066
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,495,988
Number of Sequences: 37866
Number of extensions: 1837574
Number of successful extensions: 6726
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 5522
Number of HSP's gapped (non-prelim): 880
length of query: 900
length of database: 18,247,518
effective HSP length: 111
effective length of query: 789
effective length of database: 14,044,392
effective search space: 11081025288
effective search space used: 11081025288
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.