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Search of human proteins with 114155142
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
(2363 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 4521 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 241 8e-63
gi|21735548 centrosomal protein 2 [Homo sapiens] 239 2e-62
gi|71061468 centromere protein E [Homo sapiens] 237 9e-62
gi|148746195 trichohyalin [Homo sapiens] 221 7e-57
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 216 3e-55
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 207 1e-52
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 206 2e-52
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 206 2e-52
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 206 2e-52
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 206 2e-52
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 206 2e-52
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 206 2e-52
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 206 2e-52
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 206 2e-52
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 206 2e-52
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 202 2e-51
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 202 3e-51
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 199 3e-50
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 187 8e-47
gi|55770834 centromere protein F [Homo sapiens] 186 2e-46
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 183 2e-45
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 182 3e-45
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 180 1e-44
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 180 2e-44
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 177 8e-44
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 177 1e-43
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 175 5e-43
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 175 5e-43
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 174 7e-43
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 4521 bits (11725), Expect = 0.0
Identities = 2363/2363 (100%), Positives = 2363/2363 (100%)
Query: 1 MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR 60
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR
Sbjct: 1 MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR 60
Query: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM
Sbjct: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
Query: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS
Sbjct: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
Query: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL
Sbjct: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
Query: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN
Sbjct: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
Query: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS
Sbjct: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
Query: 481 VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY
Sbjct: 481 VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
Query: 541 RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ 600
RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ
Sbjct: 541 RNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ 600
Query: 601 MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660
MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI
Sbjct: 601 MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660
Query: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF
Sbjct: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
Query: 721 ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780
ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR
Sbjct: 721 ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780
Query: 781 AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ
Sbjct: 781 AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
Query: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
Query: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS
Sbjct: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
Query: 961 NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD 1020
NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD
Sbjct: 961 NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQD 1020
Query: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN 1080
DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN
Sbjct: 1021 DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQN 1080
Query: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140
KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD
Sbjct: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140
Query: 1141 EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL 1200
EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL
Sbjct: 1141 EVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL 1200
Query: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260
RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE
Sbjct: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHE 1260
Query: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM
Sbjct: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM 1320
Query: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA
Sbjct: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
Query: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR
Sbjct: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
Query: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL
Sbjct: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
Query: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA
Sbjct: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
Query: 1561 KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH
Sbjct: 1561 KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK 1680
QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK
Sbjct: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK 1680
Query: 1681 VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV 1740
VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV
Sbjct: 1681 VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPV 1740
Query: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800
FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV
Sbjct: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV 1800
Query: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK 1860
VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK
Sbjct: 1801 VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLK 1860
Query: 1861 SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL 1920
SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL
Sbjct: 1861 SVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDL 1920
Query: 1921 GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG 1980
GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG
Sbjct: 1921 GPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTG 1980
Query: 1981 MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG 2040
MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG
Sbjct: 1981 MGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEG 2040
Query: 2041 NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR 2100
NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR
Sbjct: 2041 NTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR 2100
Query: 2101 IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG 2160
IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG
Sbjct: 2101 IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAG 2160
Query: 2161 VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA 2220
VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA
Sbjct: 2161 VPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAA 2220
Query: 2221 PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG 2280
PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG
Sbjct: 2221 PVTVFTESTTSDASEHASQSVPMVTTSTGTLSTTNETATGDDGDEVFVEAESEGISSEAG 2280
Query: 2281 LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ 2340
LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ
Sbjct: 2281 LEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQ 2340
Query: 2341 FNRQRGVSHAMGGRGGINRGNIN 2363
FNRQRGVSHAMGGRGGINRGNIN
Sbjct: 2341 FNRQRGVSHAMGGRGGINRGNIN 2363
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 241 bits (614), Expect = 8e-63
Identities = 386/1768 (21%), Positives = 764/1768 (43%), Gaps = 269/1768 (15%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKF--KVESEQQYFEI-EKRL 61
LQ +L +++ +K + + E+ DQQ++ K E+F +E + QY + + ++
Sbjct: 174 LQGILSQSQ-DKSLRRIAELREELQMDQQAK----KHLQEEFDASLEEKDQYISVLQTQV 228
Query: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALT-EKNKELEIAQDRNIAIQSQFTRTKEEL 120
S ++RL N L+ L +L Q + T E+N E + E
Sbjct: 229 SLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPESD-----------------GEP 270
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
E ++T E L Q ++ +KR E ++ K + L E +A + R
Sbjct: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSH---KEQCTLLTSEKEALQEQLDERL 327
Query: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC----NLENKKEEVSRL 236
+ LE+ K+L ++ T L T+L+ + + L ++KG I E K LE K+EE+++L
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDS 296
++ + T E L++ E K ++A+ EE L +A
Sbjct: 388 RSRIKQMTTQGEELREQKE---------KSERAAFEE-----------LEKALSTAQKTE 427
Query: 297 EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEK--EL 353
EA+ E++ + K + E ++Q L V+Q D M+K E+I +L+K E
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487
Query: 354 ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEK 413
E A TK+ L E A+ K +K+++ E Q+ L LE+
Sbjct: 488 ELARKEQELTKK----LQTREREFQEQMKVALEKSQSEYLKISQ----EKEQQESLALEE 539
Query: 414 LENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ------- 466
LE ++ I+ E E K L+++ E Y + + L LE++++E +
Sbjct: 540 LELQK-----KAILTESENKLRDLQQEAETY---RTRILELESSLEKSLQENKNQSKDLA 591
Query: 467 -RLQEDTDKANKQSSVL-ERDNRRMEI-----------QVKDLSQQIRVLLMELE---EA 510
L+ + +K NK+ +V+ E+ +E +++ L QQ + + +L E
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 511 RGNHVIRDEE-VSSADISSSSEVISQHL-VSYRNIEELQQQNQRLLVALRELGETREREE 568
+++D+E + A I +E + L V +E L + +L A +L E +
Sbjct: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
Query: 569 QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPL 628
+T K EL+ K++ + + H Q VDSI+++ + + Q T A+
Sbjct: 712 DQTDKMK-QELEAKMD----------EQKNHHQQQVDSIIKEHE----VSIQRTEKALKD 756
Query: 629 HASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST-EAIEAKAALKQLQEIFENYKKEKA 687
+ L ++ L K Q + S E +A A L ++F++Y+
Sbjct: 757 QINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL----DVFQSYQSATH 811
Query: 688 ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQ 747
E K EQL +LQ+++ DL ++ ++ Q+ + + + ++ ++ ++ L Q
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---MQ 868
Query: 748 KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
+L + EQ + ++TQ V E + E+ KE+E K ++ ++E+++
Sbjct: 869 QLEKQNSEMEQKVKSLTQ----------VYESKLEDGNKEQEQTK----QILVEKENMIL 914
Query: 808 EQR-GQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
+ R GQ + IL + + + + E+ E + + +KK+E ++ +
Sbjct: 915 QMREGQKKEIE-------ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 867 RNLDVQLLDTKRQLDTE---TNLHLNTKE------LLKNAQKEIATLKQHLSNMEVQVAS 917
L +LLD + +L E T L L+ KE +L+ AQ A + +S +E
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 918 QSSQRTGKGQPSNKEDVDDLVS-------------------QLRQTEEQVNDLKERLKTS 958
Q T ++ +++D++S QL++ E++V +LK+++
Sbjct: 1028 QIESLT----EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Query: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE---VRLKESAEFQTQLEKKLMEVE--- 1012
E+ +T L+E K+ E+++ ++ + A+ +T+L+ L ++E
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
Query: 1013 ----KEKQELQD---DKRRAIESMEQQLSELKKTLSSVQNEVQ---EALQRASTALSNEQ 1062
KE LQ+ + + E ++++SEL L + E Q + ++++ +L ++
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
Query: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
+ E+ I ++ K + E +L A E + + + + + S H + T K +
Sbjct: 1204 LEFKKLSEELAIQLDICCK-KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
Query: 1123 QLL--ECKAS--------WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
LL C S E + L + + E+ E Q + + IE L + A
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 1173 SVKEGVQGPLNVSLSEEGKSQ--EQILEILRFIR-REKEIAETRFEVAQVESLRYRQRVE 1229
KEG S E +Q +++ E + + ++E+ E + E++ + V+
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 1230 LLER-ELQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMN--------VVMETNKML 1279
L L E + ++++ R++ + + + Q ++L K +T++ V + +
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 1280 REEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
E K++ + Q Q V++L++ L+ + E EK + K+ L++ KR+
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQ---LELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN-------- 1391
+ + + +E L +E + T RI +L + I + EI N L N
Sbjct: 1500 GEMEDDKSKMEKKE-SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI--------TQVKKIGRRYKT 1443
++ L+Q L + ++ EK+ K+ + KI+ ++ +V ++ +++ + K+
Sbjct: 1559 HKELVQKL-QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
Query: 1444 QYEELKAQQDKVMETSAQSSGD---HQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
+ EELKA +D++ SA + EQ ++ + Q L + + E K ES + L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 1501 QKTLSEKETEARNLQEQTVQLQSELS------RLRQDLQDRTTQEEQLRQQITEK--EEK 1552
L E+E E L+E+ ++S S R +++ T QEE Q +K EEK
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISR 1612
++ ++ LT E E+L QR G Q+K+E ++ QY+ R+ +
Sbjct: 1738 --------------ISVLQRNLT-EKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIK 1779
Query: 1613 LER-ELREHQERHL--EQRDEPQEPSNK 1637
LE E ++H+++ + ++E +E + K
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKK 1807
Score = 219 bits (557), Expect = 3e-56
Identities = 388/1815 (21%), Positives = 780/1815 (42%), Gaps = 250/1815 (13%)
Query: 14 LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVES----EQQYFEIEKRLSHSQERLV 69
L LP+ ++ + E F ++ E DG + V++ +Q+ E L +E +
Sbjct: 245 LKPLPQ-LEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 70 NETRECQSLRLELEKLNNQLKALT---EKNKELEIAQDRNIAIQSQFTRTK-EELEAEKR 125
+ +C L E E L QL EK K+L +A+ + Q + + E+LE +K
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
Query: 126 DLI-RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-----DVSVKYR 179
+I T ++ + LE E++ +L ++K+ T EL+ + ++ + + + ++
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 180 EKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE-------------KGNEILELKCNL 226
+K E ++L + + T KT +E ++L +E K +E K
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK-------LKEAKEQQASME-EKFHNE 278
++KE + +E L+T Q+ ++ L K + + KEQQ S+ E+ +
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 279 LNAHIKLS-NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
A + S N + ++E + L K L+E +K + HL E K++
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL---EAEKNK 600
Query: 338 MEKEMLEKIGRLEKELENANDLLSAT-KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
KE+ + + + ELE+ A K +L ++ M + + +K
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 397 EL-YNAYVETQDQLLLEKLENKR-----INKYLDEIVK---EVEAKAPILKRQREEYERA 447
E+ + A++E ++ LEKL+ K+ ++ L E++K ++E + +LK Q ++ ++
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ- 719
Query: 448 QKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMEL 507
L K+++ Q+ + K ++ S +R E +KD Q+ +LL E
Sbjct: 720 -----ELEAKMDEQKNHHQQQVDSIIKEHEVSI------QRTEKALKDQINQLELLLKER 768
Query: 508 EEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE-LGETRER 566
++ H E + ADI S + Q + Q A E L + +++
Sbjct: 769 DKHLKEHQAHVENLE-ADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 567 -----EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
E+ + ++ E++ + + TEL+ H++Q+ D +++Q + + Q
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDA------HKIQVQD-LMQQLEKQNSEMEQK 880
Query: 622 TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA-------IEAKAALKQ 674
++ S L+D + K ++ + +++ E + K + K+
Sbjct: 881 VKSLTQVYESKLEDGN-----KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935
Query: 675 -----LQEIFEN-YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLD--------- 719
L E +E +K ++ + EK++ + E + L Q K+ +L+
Sbjct: 936 DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995
Query: 720 ---FASKRYEMLQDNVEGYRREITSLHERNQK-----LTATTQKQ--------EQIINTM 763
F +K EM Q N G ++ L E NQK LT +++ E+ +N
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054
Query: 764 TQDLRGANE------KLAVAEVRA---------ENLKKEKEMLKLSEVR----LSQQRES 804
++L+ +E + VAE++ E + KE LK V+ L++ +E
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQ 1114
Query: 805 LLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI-------------EKLEHEISHL 851
L + N L + ++ LE+ E + + L E+ + ++S L
Sbjct: 1115 LKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSEL 1174
Query: 852 KKKLENEVEQRHTL-------TRNLDVQLLDTKRQLDTETNLHLN-----TKELLKNAQK 899
KL+ E+ +L ++L+ + L+ K+ L E + L+ T+ LL+
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK-LSEELAIQLDICCKKTEALLEAKTN 1233
Query: 900 EIATLKQHLSNMEVQVASQSSQRTGKGQPS---NKEDVDDLVSQLRQTEEQVNDLKERLK 956
E+ + +N + S RT K + + V +L +QLRQ E+ N L +
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 957 TSTSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME--- 1010
+T +E+ + + S++ ESL EK+ ++ N + E TQL+K+L E
Sbjct: 1294 QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENIN 1353
Query: 1011 -VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ 1069
V K+EL++ K+ I S+ +QL++L L QN + + + A+ + +Q C+
Sbjct: 1354 AVTLMKEELKE-KKVEISSLSKQLTDLNVQL---QNSISLSEKEAAISSLRKQYDEEKCE 1409
Query: 1070 EQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
+ + Q+ + L + AL+ + +K + ++ + + ++ + E +
Sbjct: 1410 ----LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 1130 SWEERERMLKDEVSKCVCRCEDLEKQNR---LLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
E + + ++ + E+L++QN+ L ++E DK KE +L
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME--DDKSKMEKKES-------NL 1516
Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL--RYRQRVELLEREL-QELQDSLN 1243
E KSQ R + E I + E+ + + Y Q+ ++ +EL Q+LQ
Sbjct: 1517 ETELKSQTA-----RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE 1571
Query: 1244 AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD 1303
EK + + L + +M +ET K +E E + ++ + +++ LE D
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKK---KELEHVNLSVKSKEEELKALE-D 1627
Query: 1304 ILPLQEAN--AELSEKSGMLQA--EKKLL---EEDVKRWKARNQHLVSQQKDPDTEEYRK 1356
L + A AEL K+ A +K+LL EE +++K + +S+ E R+
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 1357 --LLSEKEVHTKRIQQLTEEIGRLKAEIAR-SNASLTNNQNLIQSLKED----LNKVRTE 1409
+L EK + Q T + R +A + ++Q +Q E+ L + TE
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 1410 KETIQKDLDAKIIDIQEKVKTITQVKKIGRRY-----KTQYEELKAQQDKVMETSAQSSG 1464
KE + + + QEK +T++ ++ +Y K ++ E K +D+ M Q
Sbjct: 1748 KEKLLQRVG------QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801
Query: 1465 DHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
+ + + S+ Q +++ + ++K +LE+ +++QKTL EKE + L+++ +L S
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 1524 ELSRLRQ----DLQDRTTQEEQLR--QQITEKEEKTR--KAIVAAKSKIAHLAGVK--DQ 1573
L R ++ ++++ T++ E+L+ QQ+ + + T + KSK +HL K
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK-SHLVQPKLLSN 1920
Query: 1574 LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
+ ++ +L+ + +++K +L I L Q + R+ R E + QE + +++ QE
Sbjct: 1921 MEAQHNDLEFKLAGAEREKQKLGKEIVRL--QKDLRMLRKEHQ----QELEILKKEYDQE 1974
Query: 1634 PSNKVPEQQRQITLK 1648
K+ ++Q + LK
Sbjct: 1975 REEKIKQEQEDLELK 1989
Score = 211 bits (536), Expect = 9e-54
Identities = 352/1693 (20%), Positives = 709/1693 (41%), Gaps = 250/1693 (14%)
Query: 5 LQQVLE--RTELNKLPKSVQNKLEKFL---ADQQSEIDGLKGRHEK-FKVESEQQYFEIE 58
LQQ E RT + +L S++ L++ D ++ K +H K V E+ E+E
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
Query: 59 KRLSHSQERLVNETREC--QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
L H Q+ L E + Q + E+EKL + E+ KE + +D+ I Q+
Sbjct: 618 S-LKHQQDALWTEKLQVLKQQYQTEMEKLREKC----EQEKET-LLKDKEIIFQAHIEEM 671
Query: 117 KEELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDE--- 168
E+ EK D+ +T E LS EL + + +L E+L +++ K EL+ K+DE
Sbjct: 672 NEKT-LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 169 ---------LQASDVSVKYREKRLEQE---KELLHSQNTWLNTELKTKTDELLALGREKG 216
++ +VS++ EK L+ + ELL + E + + L A +
Sbjct: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 217 NEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH 276
E+ + L+ + S EQ + LQ+ + DL T+ +Q A +E +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 277 N---ELNAH-IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
+ EL+AH I++ +L + E +++E+ + V+ L ++ + E Q+ ++
Sbjct: 851 DVCTELDAHKIQVQDLMQQL----EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL 906
Query: 333 QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
K+ M +M E +KE+E LSA + IL+EE + K+ +
Sbjct: 907 VEKENMILQMREG---QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
Query: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
++ E + Q+ L ++LEN L+ KE + A +L+ + AV+
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTA----LELSQKEKQFNAKMLEMAQANSAGISDAVS 1019
Query: 453 SLSVKLEQAMKEIQRL--QEDTD-------KANKQSSVLERDN----RRMEIQVKDLSQQ 499
L ++ ++ + + +E D K N+Q+ L+ + + E +V +L Q+
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQK 1079
Query: 500 IRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE 559
I + E EE EE D ++ +E+ Q ++ L Q +L L +
Sbjct: 1080 ILLFGCEKEEMNKEITWLKEEGVKQD-TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
Query: 560 LGETREREEQETT----------------SSKITELQLKLESALTELEQLRKSRQHQMQL 603
L + +E T K++EL KL++ E + L+ S + +
Sbjct: 1139 LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Query: 604 VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663
++ + + LS+ + + + + + A T + + S +
Sbjct: 1199 LED----KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS------------- 1241
Query: 664 EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASK 723
+ A L ++ K K E I+ + +L+ Q+ L + ++ A+
Sbjct: 1242 ---KTNAILSRISHCQHRTTKVK-EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
Query: 724 RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT----MTQDLRGANEKLAVAEV 779
+ E ++ ++ + +I SL + L Q+Q + +TQ + +E + +
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 780 RAENLKKEKEML-----KLSEVRLSQQRESLLAEQRGQNLLLTN---------LQTIQGI 825
E LK++K + +L+++ + Q L+E+ L L +Q +
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
Query: 826 LERSETETKQRLSS--QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQL-LDTKRQLDT 882
+ +T +K+++S+ Q++ ++ S KKK ++ Q + L +QL L +K +
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
Query: 883 ETNLHLNTKELLKNAQKEIATLKQHL-----------SNMEVQVASQSS----------Q 921
+ ++L KE L K LK + SN+E ++ SQ++ Q
Sbjct: 1478 DEQINL-LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 922 RTGKGQPSNK--------EDVD--DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
+T + + N+ +D++ +LV +L+ +E + R+K + + + V S
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596
Query: 972 LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK----KLMEVE-KEKQELQDDKRRAI 1026
++ L +K+ E V +++ + +E + +LE KL E++ K +Q++ K++ +
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656
Query: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
ME++ + KK S +E+ LQ E++ E+ +VE+ E +
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQ--------EREREVHILEEKLKSVESSQS-ETLI 1707
Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV--SK 1144
+ +A A +E+ V++ EE + L E K +R K+E S
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE-KEKLLQRVGQEKEETVSSH 1766
Query: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
RC+ E+ +L H + ++ D + + G L L E+ K I + + +
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHED-------QSMIGHLQEELEEKNKKYSLI--VAQHVE 1817
Query: 1205 RE--------KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTM 1256
+E K+ E F+ Q ++LE++++EL L ++E +V + +
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQD-------LQQMQAKVRKLELDILPLQE 1309
E ++ + M+ + ++L E E + L M+A+ LE + +
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER 1937
Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE----VHT 1365
+L ++ LQ + ++L K Q L +K+ D E K+ E+E H
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLR------KEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991
Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ 1425
++QL E A+ Q L ++KE +NK + +++A++++
Sbjct: 1992 STLKQLMREFNTQLAQ---------KEQELEMTIKETINKAQ--------EVEAELLESH 2034
Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
++ +T +KKI A++D ++ +A+ +E+ + +E +
Sbjct: 2035 QE-ETNQLLKKI------------AEKDDDLKRTAKR----------YEEILDARE--EE 2069
Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTV---QLQSELSRLRQDLQDRTTQEEQL 1542
K + L++Q+E LQK +K + N V +LQ++L++ + D +E++
Sbjct: 2070 MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF 2129
Query: 1543 RQQITEKEEKTRK 1555
R+QI E++ +K
Sbjct: 2130 REQIHNLEDRLKK 2142
Score = 189 bits (480), Expect = 3e-47
Identities = 332/1558 (21%), Positives = 688/1558 (44%), Gaps = 191/1558 (12%)
Query: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
++++E DL+ ++ L++E L + ++R+ L EL LQ
Sbjct: 119 DMDSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQ-------- 168
Query: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
REK+ + + L SQ+ L + + +EL + K + E +LE K + +S L+
Sbjct: 169 REKK-KLQGILSQSQDKSLRRIAELR-EELQMDQQAKKHLQEEFDASLEEKDQYISVLQT 226
Query: 239 QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
Q++ LK + +V D+L L + + Q E F E N S+ D +
Sbjct: 227 QVSLLKQRLRNGPMNV-DVLKPLPQLEPQA----EVFTKEENPE---SDGEPVVEDGTSV 278
Query: 299 KSNE-LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
K+ E L + V+ LLK E ++ ++ + K+ +++++ E++ +ELE
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL----QELEKIK 334
Query: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP-GMKLTELYNAYVETQDQLLLEKLEN 416
DL A K K + + + ++ + GM + E ET LE E
Sbjct: 335 DLHMAEKTK-------LITQLRDAKNLIEQLEQDKGMVIAETKRQMHET-----LEMKEE 382
Query: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERA-----QKAVASLSVKLEQAMKEIQRLQED 471
+ L +K++ + L+ Q+E+ ERA +KA+ S + K E+A ++++ ++
Sbjct: 383 EIAQ--LRSRIKQMTTQGEELREQKEKSERAAFEELEKAL-STAQKTEEARRKLKAEMDE 439
Query: 472 TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
K +++S ER + + E LS+ + ++ ++++ + + +++ +++ +
Sbjct: 440 QIKTIEKTSEEERISLQQE-----LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 532 VISQHLVSYRNIEELQQQNQRLLVALRE-----LGETREREEQETTSSKITELQLKLESA 586
+++ L + E Q+Q + VAL + L ++E+E+QE+ + + EL+L+ ++
Sbjct: 495 ELTKKLQTRER--EFQEQ---MKVALEKSQSEYLKISQEKEQQESLA--LEELELQKKAI 547
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
LTE E + Q ++ + YR + + SSL+ S + +
Sbjct: 548 LTESENKLRDLQ----------QEAETYRTRILELE--------SSLEK----SLQENKN 585
Query: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ----LEKLQE 702
S+ ++ +EA+ K +EI +K K E E ++++Q EKLQ
Sbjct: 586 QSKDLAVH-----------LEAEKN-KHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633
Query: 703 QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN-QKLTATTQKQEQIIN 761
+++ K+ + + ++ +L+D ++ I ++E+ +KL + E + +
Sbjct: 634 LKQQYQTEMEKLREKCE--QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691
Query: 762 TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
+++ L+ ++ L++E +LK ++ Q+ E+ + EQ+ + Q
Sbjct: 692 ELSEVLKARHK-----------LEEELSVLKDQTDKMKQELEAKMDEQKNHHQ-----QQ 735
Query: 822 IQGILERSETE---TKQRLSSQIEKLEHEISHLKKKLENE---VEQRHTLTRNLDVQLLD 875
+ I++ E T++ L QI +LE + K L+ VE + + +L
Sbjct: 736 VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQ 795
Query: 876 TKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD 935
+LD + T E K ++++A L+Q L ++E + + Q + + K
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ-VAEVEAQKK---- 850
Query: 936 DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL----NKEKQVTEEV---RK 988
D+ ++L + QV DL ++L+ S +EQ +T + ES NKE++ T+++ ++
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI-ESMEQQLSELKKTLSSVQNEV 1047
N+ ++++E +KK +E+ +K ++D + E E + +K + V+ +
Sbjct: 911 NMILQMREG-------QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA 963
Query: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM- 1106
+E + L +++ + E + + + K ML A + + VS++
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA-GISDAVSRLE 1022
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
+ ++ +E T+ +L + + WE++ +E+ + +++ Q + ++ +L
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI----HEIQLQEK--EQEVAEL 1076
Query: 1167 SDKVVASVKEGVQGPLNVS-LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYR 1225
K++ E + ++ L EEG Q+ L L+ ++K +AQ E+ + +
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN--SLAQDET-KLK 1133
Query: 1226 QRVELLERELQE-LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
+E LE +L + L+++ + + V++ ++ + T + E + L+ E
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193
Query: 1285 RLEQDLQQMQAKVRKL------ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
+ + L+ + +KL +LDI ++ A L K+ L + +
Sbjct: 1194 KSNKSLEDKSLEFKKLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
QH ++ K+ + +SE E +++QLTEE L ++ L +N I+S
Sbjct: 1253 CQHRTTKVKEALLIK-TCTVSELEA---QLRQLTEEQNTLNISFQQATHQLEEKENQIKS 1308
Query: 1399 LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK-IGRRYKT---QYEELKAQQDK 1454
+K D+ + TEKE +QK+ + EK ITQ+KK + EELK ++ +
Sbjct: 1309 MKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVE 1368
Query: 1455 VMETSAQSS--GDHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENLQKTLSEKETEA 1511
+ S Q + + +S+ E + +L + + K L QV++L + E
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
Query: 1512 RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVK 1571
+ EQ ++ S ++ Q R TQ Q T KE + + + KSK A+
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQ-----HQNTVKELQIQ---LELKSKEAY--EKD 1478
Query: 1572 DQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRD 1629
+Q+ EEL Q+N D K E++ KS+ E + S LE EL+ R +E D
Sbjct: 1479 EQINLLKEELDQQNKRFDCLKGEMEDD----KSKMEKKESNLETELKSQTARIMELED 1532
Score = 61.2 bits (147), Expect = 1e-08
Identities = 75/371 (20%), Positives = 164/371 (44%), Gaps = 44/371 (11%)
Query: 1291 QQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD 1350
+Q+ ++R++E + + +EL MLQ EKK L Q ++SQ +D
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL-----------QGILSQSQDKS 185
Query: 1351 TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
+L E ++ + + L EE +ASL I L+ ++ ++
Sbjct: 186 LRRIAELREELQMDQQAKKHLQEEF----------DASLEEKDQYISVLQTQVSLLKQRL 235
Query: 1411 ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ-SSGDHQEQ 1469
++D +K + Q++ + T+ E ++ + V+E + + +Q
Sbjct: 236 RNGPMNVDV--------LKPLPQLEPQAEVF-TKEENPESDGEPVVEDGTSVKTLETLQQ 286
Query: 1470 HVSVQE--MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
V QE ++ KET+ + + L S+ E LQ+ L E+ E +++ + +E ++
Sbjct: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM---AEKTK 343
Query: 1528 LRQDLQDRTTQEEQLRQQ----ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
L L+D EQL Q I E + + + + + +IA L Q+T + EEL++
Sbjct: 344 LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403
Query: 1584 RNGALDQQK-DELDVRITALKSQYEGR---ISRLERELREHQERHLEQRDEPQEPSNKVP 1639
+ ++ +EL+ ++ + E R + ++ +++ ++ E+R Q+ ++V
Sbjct: 404 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463
Query: 1640 EQQRQITLKTT 1650
++ + K++
Sbjct: 464 QEVVDVMKKSS 474
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 239 bits (611), Expect = 2e-62
Identities = 361/1726 (20%), Positives = 742/1726 (42%), Gaps = 244/1726 (14%)
Query: 20 SVQNKLEKFLADQQSEIDGLKGRHEKF---KVESEQQYFEIEKRLSHSQERLVNETRECQ 76
S +N L+ +AD ++ L +E KV QQ ++E+ R+ +
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 77 SLRLELEKLNNQLKALTEKNKELEI----AQDRNIAIQSQFTRTKEELEAEKRDLIRTN- 131
+L+++L + + +AL EKN LE A++ +Q+ +EE E ++ L +
Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
Query: 132 --ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
E + +LE L ++ KR E L + K L + L+ +V+ + L ++ +
Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
L S L + L + + KG LE++ + +EV + E + L+ E
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTER 819
Query: 250 LQKHVE-DLLTKL--------KEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
Q E D + K A EQQ + EK N+L + +S AK+
Sbjct: 820 SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE---RSWHQQELAKA 876
Query: 301 NE-LTRAVEELHKLLKEAGEANKAIQ----DHLLEVEQSKDQMEKE-------MLEKIGR 348
E L R EL LKE +AIQ + + E + QM+ E +LE + +
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 349 LEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAK--IVKPGMKLTELYNAYVE 404
+KEL +A+ L ++ + L E+E + T A+ + + + + A E
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
Query: 405 TQDQLLLEKLE-NKRINKYLDEIVKE------VEAKAPILKRQREEYERAQKAV----AS 453
LL +K++ K++ ++V + VE + R+ +EY R QK + AS
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS 1056
Query: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
L++ L + + + LQE ++ S L +D + + + K+LS Q+ +L E++E +
Sbjct: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
Query: 514 HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
+ ++ ++ +EEL+ + + E + R
Sbjct: 1117 FLAQEAQL---------------------LEELEASH---------ITEQQLRASLWAQE 1146
Query: 574 SKITELQLKLESALTELEQLRKSRQ--HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHAS 631
+K +LQL+L S ++LE L +Q +Q Q + + L L
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
Query: 632 SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEK 691
S+ + ++++ P+ S EA+ A A K Q++++ +
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV-ASALHKLHQDLWKTQ-----QTRD 1260
Query: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
+ +Q++KL+E++TD ++ +++ T+L + +R+++ E K
Sbjct: 1261 VLRDQVQKLEERLTDTEAEKSQVHTEL--------------QDLQRQLSQNQEEKSKWEG 1306
Query: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA---E 808
E + + + + +L AE++ + E+E+L+ ++ L+ Q E L A E
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366
Query: 809 QRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRN 868
R Q + GILE + L KL++E ++E+E E+ L
Sbjct: 1367 ARAQ-------ASAAGILEEDLRTARSAL-----KLKNE------EVESERERAQALQEQ 1408
Query: 869 LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
++++ K + NL L T+ L + ++E+ TL+ + +E Q Q
Sbjct: 1409 GELKVAQGKA---LQENLALLTQTLAER-EEEVETLRGQIQELEKQREMQ---------- 1454
Query: 929 SNKEDVDDLVSQLRQTEEQVNDLKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
K ++ L L++ ++V+ +E+ L+ S +E V E+ L +++ E
Sbjct: 1455 --KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512
Query: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI--ESMEQQLSELKKTLSSV 1043
+ K+ E + +LEKK +E ++ ++QD K++ + E + +L E +
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ 1572
Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV--------EA 1095
Q ++E + T D +E+++ ++AQ+ +L H+ + +
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQ-ELQAQSSQIHDLESHSTVLARELQERDQE 1631
Query: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
+++ +EQ+ ++ ++HL + ++ + +L+ K ER ++L+D+ ++ Q
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQK----ERIQVLEDQRTR----------Q 1677
Query: 1156 NRLLHDQIEKLSDKVVASVKE-GVQGPLNVSLSEEGK----SQEQILEILRFIRREKEIA 1210
++L + +E++ + +E Q L +EEGK +Q LE ++ I R+KE
Sbjct: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE-- 1735
Query: 1211 ETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN 1270
+ VE + + ELQ+ + +++Q + + + L+ + E
Sbjct: 1736 ---------------KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
VV++ + L+E +E+ E Q +Q+++ + + + + L ++ Q +++ ++E
Sbjct: 1781 VVLQ--QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 1331 --DVKRWKARNQHLVSQQKDPDTEEY----RKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
D + H+ +++ + +++ R+L E V +R+Q L E +G L+AE
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKD-LDAKIIDIQEKVKTITQVKKIGRRYKT 1443
+L Q Q E + E +Q L A+ + ++E+ + + ++ + +
Sbjct: 1899 QEKALLALQ---QQCAEQAQEHEVETRALQDSWLQAQAV-LKERDQELEALRAESQSSRH 1954
Query: 1444 QYEELKAQQDKVMET--SAQSSGDHQEQHVSVQ---------EMQELKETLNQAETKSKS 1492
Q E +A+ + + E A ++ +EQH+ Q L+ +L+ + S+
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 1493 LES------------------QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
LE V+ LQ+ L++++ E R+ QE+ L+ L+ Q +Q+
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA---QRVQE 2071
Query: 1535 RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNG--ALDQQK 1592
QE+Q Q E+EE+ + + + ++ K+Q E E +QRN AL
Sbjct: 2072 NMIQEKQNLGQ--EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 1593 -----DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
+E +++ +L+ + + + RL+ LR+ + R +E R++ Q+
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQD 2175
Score = 228 bits (580), Expect = 7e-59
Identities = 366/1739 (21%), Positives = 728/1739 (41%), Gaps = 255/1739 (14%)
Query: 24 KLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELE 83
+LEK ++ E+ LK + + K E + + E+ L+ SQ++ + + ++LR +E
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
Query: 84 KLNNQLKALTEKNKELEI-AQDRNIAIQSQFTRTKEELEAEKRDLI----------RTNE 132
L L E L AQ+ +++Q Q + ++ E+ D I +
Sbjct: 315 ILETNHTELMEHEASLSRNAQEEKLSLQ-QVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
Query: 133 RLSQELEYLTED----------------VKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
+ + +Y D V+ L ++L LQ + D+ + ++
Sbjct: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
Query: 177 KYREKRLEQEKELLHSQNTWLNTELKT--KTDELLALGREKGNEILEL---------KCN 225
+ R ++L E++ L Q L E+ + K ELL RE+ + LE+ + N
Sbjct: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
Query: 226 LE---------NKKEEVS-----------RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK 265
+E +KEE RL+E + GL+ + + +L+T L+EA
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS---ESLSELIT-LREAL 549
Query: 266 EQQASMEEKFHNE-LNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI 324
E E E L+ +S A+ S ++ N L V +L + N+A+
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEAL 608
Query: 325 QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN----DLLSATKRKGAILSEEELAAMSP 380
+ + Q Q+E+E R+E + N DL A KR+ A+ + +
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN-----TH 663
Query: 381 TAAAVAKIVKPGMKLT----ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI 436
A + K + G +L ++ E Q +L + + + L+++ +E + + +
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 437 LKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD--------------KANKQSSVL 482
L R +E E + A+L V+L+ ++ Q L E +A +Q+SV+
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 483 ERDNRRMEIQVKDLSQ-------QIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ 535
E ++E+Q++ ++Q ++R L +EL+ R + ++ + ++ ++ + +
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER-SQAEQERDAAARQLAQAEQEGKT 842
Query: 536 HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
L + E +E+ + RE+ E+E + + EL LES E +L
Sbjct: 843 ALEQQKAAHE------------KEVNQLREKWEKERSWHQ-QELAKALESLEREKMELEM 889
Query: 596 SRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPA 655
+ Q +++I QR+ R S+L + L + +R S +T+
Sbjct: 890 RLKEQQTEMEAIQAQREEERTQAE-----------SALCQMQLETEKERVSLLETL---- 934
Query: 656 PVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIS 715
+ E +A L++L++ + K ++ E I QL++ Q ++ + Q+
Sbjct: 935 ---LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 716 TQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLA 775
L S +LQD ++ ++ + + +L A Q + + + LR E
Sbjct: 992 AALQEESS--SLLQDKMDLQKQ----VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 776 VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
+ + L++EK L LS L ++ + LL Q ++ L ++ ++ ++ E K+
Sbjct: 1046 IQK----ELEREKASLTLS---LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098
Query: 836 RLSSQIEKLEHEISHLKK-------KLENEVEQRHTLTRNLDVQLLDTK--------RQL 880
LS+Q+E L E+ + +L E+E H + L L + R
Sbjct: 1099 -LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157
Query: 881 DTETNLHLNTKELLKN----AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
TE+ L E AQ ++A+L L V + +G G D
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG------DSAP 1211
Query: 937 LVSQLRQTEEQVNDLKERLKTSTS-NVEQYQAMVTSLEESLNKEKQVTEEVR---KNIEV 992
V L + L +R T+ + E + + L + L K +Q + +R + +E
Sbjct: 1212 SVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE 1271
Query: 993 RLKESAEFQTQLEKKLMEVEKEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQE 1049
RL ++ ++Q+ +L +++++ + Q++K + S+E +L EL +T++S+Q+ ++
Sbjct: 1272 RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR 1331
Query: 1050 A-LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108
A LQR E Q R+ + AK + AQ VE LQAA + AS
Sbjct: 1332 AELQRM------EAQGERELLQAAKENLTAQ-------------VEHLQAAVVEARAQAS 1372
Query: 1109 VRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
LEE + A S L ++ +EV R + L++Q L Q + L +
Sbjct: 1373 AAGILEEDLRTARSAL-----------KLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRV 1228
+ L +L+E + E + ++ + +++E+ + E+ ++ + Q V
Sbjct: 1422 NLAL---------LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 1229 ELLERELQELQDSLN-------AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE 1281
+L + ++QEL+ + A +E+ Q Q EL K ET V+E +
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--- 1529
Query: 1282 EKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQH 1341
E E+ +Q ++ + +V+ L+ ++ L+ EL E ++ ++KL++E
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE----------- 1578
Query: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKE 1401
+ Q++ L + E ++ +Q + +I L++ L ++S +E
Sbjct: 1579 -LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 1402 DLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ 1461
+ +++ +KE + +DL+ + ++ + + I QV + R +T+ E +Q K+ S +
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRTRQTKILEEDLEQIKL---SLR 1693
Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQL 1521
G +E Q MQE E + + SK+ +E+++ L +KE E QE +L
Sbjct: 1694 ERG--RELTTQRQLMQERAE---EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHEL 1748
Query: 1522 QSELSRLRQDLQ-------DRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q +L Q LQ + + Q Q+I +++ ++A + K L D+
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
+ + Q AL Q++ + + +K + + LE+ +ERH E +D ++
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ 1867
Score = 188 bits (478), Expect = 5e-47
Identities = 324/1589 (20%), Positives = 653/1589 (41%), Gaps = 218/1589 (13%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE----QQYFEIEKR 60
L + LE E K+ +LE L +QQ+E++ ++ + E+ + ++E Q E EK
Sbjct: 873 LAKALESLEREKM------ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926
Query: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
E L+ +E +LE+L +K +K KE Q+ +Q+Q + EL
Sbjct: 927 RVSLLETLLQTQKELADASQQLERLRQDMKV--QKLKE----QETTGILQTQLQEAQREL 980
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
+ R L +E L +D K +LQ ++++L++ V+ +
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQD--------------KMDLQKQVEDLKSQLVAQDDSQ 1026
Query: 181 KRLEQE-KELLHSQNTW--LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
+ +EQE +E L + + EL+ + L EK +L L+ +++E+S L
Sbjct: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086
Query: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
+ M + + L +E L ++KE + + E + EL A +++ E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
Query: 298 AKSNELT---RAVE-ELHKLLKEAGEANKA------------IQDHLLEVEQSKDQMEK- 340
AK+ +L R+ E +L L E N+A +Q L V +S+ ++
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
+ + LE + A L ++G +L+ A+ A+A+ K+ + K T+
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLF----KRGPLLTALSAEAV---ASALHKLHQDLWK-TQQT 1258
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLE 459
+ Q Q L E+L + K ++ E++ L + +EE + + SL +L
Sbjct: 1259 RDVLRDQVQKLEERLTDTEAEK--SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM 1316
Query: 460 QAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
+ + + LQ +A Q + + ++ ++L+ Q+ L + EAR
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA------- 1369
Query: 520 EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITEL 579
+ S+A I ++ + +N EE++ + +R AL+E GE + + + E
Sbjct: 1370 QASAAGILEEDLRTARSALKLKN-EEVESERERAQ-ALQEQGELKVAQ-----GKALQEN 1422
Query: 580 QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
L L E E+ ++ + Q+Q ++ +QR+M + L L + L
Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELE---KQREMQKAALE-------------LLSLDLK 1466
Query: 640 STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
+ Q E L++ + + E+ E E+ Q E+
Sbjct: 1467 KRNQEVDLQQ-----------------EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 700 LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
++E D +Q + QL K+ +M +E R ++ L +KQ
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQM----IESQRGQVQDL-----------KKQLVT 1554
Query: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
+ + +L + K+ + + L+ ++E +++ L+ E E + Q+ + +L
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614
Query: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR--HTLTRNLDVQLLDTK 877
++ +L R E Q + SQ E++E E+ K+ L ++E+R + + +Q+L+ +
Sbjct: 1615 ESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
Query: 878 RQLDT---ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG-QPSNKED 933
R T E +L K L+ +E+ T +Q + Q GKG + +
Sbjct: 1674 RTRQTKILEEDLE-QIKLSLRERGRELTTQRQLM---------QERAEEGKGPSKAQRGS 1723
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
++ + LR E++V +E ++ + Q + LE+ L + + +
Sbjct: 1724 LEHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQL-----------QGLHRK 1765
Query: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
+ E++ +Q E++++ ++++ QE ++ +S++ QL E ++ L+ E++
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE----- 1820
Query: 1054 ASTALSNEQQARRDCQEQAKIAVEA-QNKYERELMLHAADVEALQAAKEQVSKMASVRQH 1112
AL EQQ + +E+ K +A Q E+ M LQ KEQ ++
Sbjct: 1821 ---ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
Query: 1113 LEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHD----------- 1161
Q E L + +A E+E+ L +C + ++ E + R L D
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937
Query: 1162 ------------QIEKLSDKVVASVKEGVQGPL-NVSLSEEGKSQEQI--LEILRFIRRE 1206
Q + ++ + E +Q L + +GK Q + E+ R +
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997
Query: 1207 KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
+ + Q S RQ E L + E+QD +E VQ + +AQ +E ++
Sbjct: 1998 TATLQASLDACQAHS---RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 1267 ETMNVVMETN-------KMLREE----KERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
+ ++E + M++E+ +ER E++++ + VR+L+L + ++ EL
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
Query: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEE 1374
E E L K Q L +P + E +L + R + E+
Sbjct: 2115 ETQQRNNLE--ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172
Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK---VKTI 1431
L +A++ AS+++ Q + L+ + + +E++ +Q +L+ ++++
Sbjct: 2173 AQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGA 2232
Query: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
T ++G R E Q +V A+ S D E+ Q ++ L++ + + E
Sbjct: 2233 TSTAELGSR-----GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287
Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQ 1520
L+ L+ TL + E E R L+ + ++
Sbjct: 2288 RLQRHNVQLRSTLEQVERERRKLKREAMR 2316
Score = 165 bits (418), Expect = 4e-40
Identities = 330/1587 (20%), Positives = 630/1587 (39%), Gaps = 240/1587 (15%)
Query: 151 KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS----QNTWLNTELKTKTD 206
KLK S + + +LQA ++YR E EK L + W N E + D
Sbjct: 41 KLKNSQEAQQRQATLVRKLQAK--VLQYRSWCQELEKRLEATGGPIPQRWENVE-EPNLD 97
Query: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
ELL E+ + +C E+ E ++L M N+ L++ VE L A++
Sbjct: 98 ELLVRLEEE-----QQRC--ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARD 150
Query: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
+ E ++ E +K + L R V +
Sbjct: 151 ELMRKESQWQME-------QEFFKGYLKGEHGRLLSLWREVVTFRR-------------- 189
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
H LE++ + D+ E+ + RL L L + S E + A
Sbjct: 190 HFLEMKSATDRDLMELKAEHVRLSGSL-----LTCCLRLTVGAQSREPNGSGRMDGREPA 244
Query: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
+++ K EL E +L+ K + L + V E+ A ++Q E+YE+
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 447 AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
KA+ + ++ L+ + + + + L R+ + ++ ++ + + I +++E
Sbjct: 305 MIKALR----------ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354
Query: 507 LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
G+++ + ++ + S + SQ + Q ++ L + L TR R
Sbjct: 355 ----EGDNIAQGSGHENS-LELDSSIFSQF--------DYQDADKALTLVRSVL--TRRR 399
Query: 567 EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
+ + ++ Q E L + + Q + +RQR L + TG
Sbjct: 400 QAVQDLRQQLAGCQ--------EAVNLLQQQHDQWEEEGKALRQR------LQKLTGERD 445
Query: 627 PLHASSLD---DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ---EIFE 680
L ++D +V S + + V+E EA + +LQ + +
Sbjct: 446 TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ-EAWRLRRVNVELQLQGDSAQ 504
Query: 681 NYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGY----- 735
K+E+ E + + E+LQE + L ++ ++ ++L + R + ++EG
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL--ITLREALESSHLEGELLRQE 562
Query: 736 RREITSLHERNQKLTATTQKQEQIINTMTQDLRGA-------NEKLAVAEV--------- 779
+ E+T+ R ++ A E + T DLR A NE LA+ +V
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
Query: 780 RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSS 839
EN M + R + Q + AE+R + L N ++ L+++E E L +
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH-LEAQLQKAE-EAGAELQA 680
Query: 840 QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQK 899
+ ++ E ++KKL Q+ T L+ + KRQ +E+L A +
Sbjct: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ-----------EEVLARAVQ 729
Query: 900 EIATLKQHLSNMEVQVASQSSQRTG-----KGQPSNKEDVDDLVSQLRQTEEQVN----D 950
E L + + +EV++ + R +G S KE ++ + + +Q +
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
Query: 951 LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA-EFQTQLEKKLM 1009
L+ +++T T E Q V L+ L+ E+ E+ R +L ++ E +T LE++
Sbjct: 790 LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849
Query: 1010 EVEKEKQEL-----------QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
EKE +L Q + +A+ES+E++ EL+ L Q E+ EA+Q A
Sbjct: 850 AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM-EAIQ-AQREE 907
Query: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118
Q CQ Q + E + E L +A Q + M + +ETT
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG 967
Query: 1119 KAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGV 1178
++QL E + +E R +D+++ L + L Q+E L ++VA
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA------ 1021
Query: 1179 QGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL 1238
+ SQ + E+E+ E LR Q +++EL
Sbjct: 1022 ----------QDDSQRLV---------EQEVQE---------KLRETQEYNRIQKEL--- 1050
Query: 1239 QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR 1298
EREK +T LM+K + + V+ E + + ++E L QD+Q+ Q + +
Sbjct: 1051 ------EREKASLTLS-------LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS----QQKDPDTEEY 1354
+L + L++ E+ EK A++ L E+++ Q L + Q+ +
Sbjct: 1098 ELSAQMELLRQ---EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLT-----------------NNQNLIQ 1397
R +E ++ +Q + +A++A ++L ++ +
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214
Query: 1398 SLKEDLNKVRT--EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKV 1455
L+ D N R+ ++ + L A+ + K + K + ++++ ++++
Sbjct: 1215 GLEPDQNGARSLFKRGPLLTALSAEAV-ASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 1456 METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ 1515
+T A+ S H E +++ + +E ++ E K SLES++ L +T++ ++ R +
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 1516 EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK----------EEKTRKAIVAAKSKIA 1565
Q ++ Q E L+ ++ T Q E L+ + E EE R A A K K
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 1566 HLAGVKD--QLTKENEELKQRNGALDQQKDELDVRITALKSQ----YEGRISRLERELRE 1619
+ ++ Q +E ELK G Q+ L + A + + G+I LE++ RE
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-RE 1452
Query: 1620 HQERHLEQRD-EPQEPSNKVPEQQRQI 1645
Q+ LE + ++ + +V QQ QI
Sbjct: 1453 MQKAALELLSLDLKKRNQEVDLQQEQI 1479
Score = 148 bits (373), Expect = 7e-35
Identities = 304/1407 (21%), Positives = 585/1407 (41%), Gaps = 185/1407 (13%)
Query: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ----RLQEDTDKANKQSSVLERD 485
+E ++P L + + Q + + L+Q M E Q R +++ +A ++ + L R
Sbjct: 1 METRSPGLNNMKPQ--SLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRK 58
Query: 486 NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545
+ +Q + Q++ LE G R E V ++ E++ + + E
Sbjct: 59 LQAKVLQYRSWCQELE---KRLEATGGPIPQRWENVEEPNLD---ELLVRLEEEQQRCES 112
Query: 546 LQQQNQRLLVALRELGET----REREEQETTSSKITELQLKLESALTELEQ------LRK 595
L + N +L + + + RE E+ T +L + + ++EQ L+
Sbjct: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
Query: 596 SRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD-DVSLASTPKRPSTSQTVSTP 654
+ L +V R + + S T + L A + SL + R + P
Sbjct: 173 EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232
Query: 655 APVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNE-QLEK--LQEQVTDLRSQN 711
++ E + L + QE+ + + E +++++ LEK LQ++VT+L +
Sbjct: 233 NGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL 292
Query: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQ----EQIINTMTQDL 767
T+ Q + K + L++ VE T L E L+ Q++ +Q+I +TQ +
Sbjct: 293 TQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVM 352
Query: 768 RGANEKLAVAEVRAENLKKEKEMLK----------LSEVR---------LSQQRESLLAE 808
+ +A +L+ + + L+ VR + R+ L
Sbjct: 353 VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Query: 809 QRGQNLLLTN----LQTIQGILERSETETKQR--LSSQIEKLEHEISHLKKKLENEVEQR 862
Q NLL + + + +R + T +R L+ Q L+ E+ L K+ E + R
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
Query: 863 HTLTRNLDVQLLDTKRQLDTETNLHL----------NTKELLKNAQKEIATLKQHLSNME 912
L + L+V + R L L +E L A +E L++ L +E
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 913 ------------VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
++ A +SS G+ + +V +++ Q+ +++ + LKT +
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 961 NVEQYQAMVTSLEES-------LNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
++ +++L E+ LN++ EE +++ R++ + + + L+ L E EK
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652
Query: 1014 EKQELQDDK---RRAIESMEQQLSELKKTLSSVQNEVQEALQRAS-------TALSNEQQ 1063
++ L + ++ E+ +EL+ L +Q E +E ++ S A + +Q
Sbjct: 653 RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ 712
Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK-------EQVSKMASVRQHLEET 1116
++ + Q ++ A + E + AA LQA + EQ+ ++S ++ LE +
Sbjct: 713 LHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Query: 1117 TQKAESQLLECKASWEERERMLK-----DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
+A+ Q + + + E ++ EV + RC LE Q E+ D
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE--RSQAEQERDAAA 830
Query: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQ-VESL-RYRQRVE 1229
+ + Q +L ++ + E+ + LR + EKE + + E+A+ +ESL R + +E
Sbjct: 831 RQLAQAEQEG-KTALEQQKAAHEKEVNQLR-EKWEKERSWHQQELAKALESLEREKMELE 888
Query: 1230 LLERELQELQDSLNAEREKVQVTAKT---MAQHEELMKKTETMNVVMETNKMLREEKERL 1286
+ +E Q +++ A+RE+ + A++ Q E ++ + +++T K L + ++L
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948
Query: 1287 EQDLQQMQAKVRKLE----LDIL--PLQEANAELSEKS-------GMLQAEKKLLEEDVK 1333
E+ Q M KV+KL+ IL LQEA EL E + LQ E L +D
Sbjct: 949 ERLRQDM--KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 1334 RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQ 1393
+ + + L SQ D + L E+EV K + T+E R++ E+ R ASLT
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQ---RLVEQEVQEKLRE--TQEYNRIQKELEREKASLT--- 1058
Query: 1394 NLIQSLKEDLNKVRTEKETI-QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQ 1452
L KE V E ++I Q++L A D+QE + K++ + + +E+K ++
Sbjct: 1059 -LSLMEKEQRLLVLQEADSIRQQELSALRQDMQE---AQGEQKELSAQMELLRQEVKEKE 1114
Query: 1453 DKVMETSAQSSGDHQEQHVSVQEM------QELKETLNQAETKSKSLESQVENLQKTLSE 1506
+ AQ + + H++ Q++ QE K Q + + +S ESQ+E L
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA--QLQLRLRSTESQLEAL-----A 1167
Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLR--------------QQITEKEEK 1552
E + N + QL S S L+Q L +L Q +
Sbjct: 1168 AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227
Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT---ALKSQYEGR 1609
R ++ A S A +A +L ++ + +Q L Q +L+ R+T A KSQ
Sbjct: 1228 KRGPLLTALSAEA-VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE 1286
Query: 1610 ISRLERELREHQERHLE----------QRDEPQEPSNKVPEQQRQITLKTTPASGERG-I 1658
+ L+R+L ++QE + + E E + + R+ L+ A GER +
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346
Query: 1659 ASTSDPPTANIKPTPVVSTPSKVTAAA 1685
+ + TA ++ ++ A+A
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASA 1373
Score = 138 bits (347), Expect = 7e-32
Identities = 256/1260 (20%), Positives = 514/1260 (40%), Gaps = 166/1260 (13%)
Query: 5 LQQVLERTELNKLPKSVQ-NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSH 63
L++ L TE K + L++ L+ Q E +G+ E + E+ + ++
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL----ESELMELHETMAS 1324
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAE 123
Q RL + + E E L + LT + + L+ A A S +E+L
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE-LQASDVSVKYREKR 182
+ L NE + E E + L E +GEL++ + LQ + +
Sbjct: 1385 RSALKLKNEEVESE----RERAQALQE--------QGELKVAQGKALQENLALLTQTLAE 1432
Query: 183 LEQEKELLHSQNTWL--NTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
E+E E L Q L E++ ELL+L +K N+ ++L ++E++ LE+
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL------QQEQIQELEKCR 1486
Query: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
+ L EHL V++ KL +EQ +E+ D E +
Sbjct: 1487 SVL----EHLPMAVQEREQKLTVQREQIRELEK---------------------DRETQR 1521
Query: 301 NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLL 360
N L + EL K +D ++E ++ + Q K+ L + L ELE + +
Sbjct: 1522 NVLEHQLLELEK------------KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569
Query: 361 SATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
++ ++ E E + A LT L E +L + + +
Sbjct: 1570 ECQQK---LIKELEGQRETQRVA-----------LTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI----QRLQEDTDKAN 476
+ + +E++ + +K QRE+ E Q+ L+ LE+ +E+ +R+Q D+
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 477 KQSSVLERDNRRMEIQV----KDLSQQIRVLLMELEEARG------------NHVIRDEE 520
+Q+ +LE D ++++ + ++L+ Q +++ EE +G ++RD+E
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735
Query: 521 VSSA-------DISSSSEVISQHLVS-YRNIEE----LQQQNQRLLVALRELGETREREE 568
++ + + Q L +R + E L Q+ Q ++V ++L E RE+ E
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Query: 569 --QETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
+++ S++ E Q L ELE L++ +Q + + + D + L Q
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 627 PLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA---IEAKAALKQLQEIFENYK 683
H D A + + A V+ A + KA L Q+ E +
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 684 KEKAENEKIQNEQLE------KLQEQVTDLRSQNTKISTQLDFASKRYEMLQD------- 730
+ + E +Q+ L+ + +++ LR+++ Q + A R E LQ+
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 731 NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV--AEVRAENLKKEK 788
++G + + E ++ L A+T + ++ R E L + E++ ++L+ ++
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE 2035
Query: 789 EMLKL--------SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
++ +L E+R Q+RE LL + Q + +Q Q + + E E + L
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS 2095
Query: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
+ +L+ ++ ++++ +E R T RN +++ L + L L Q+E
Sbjct: 2096 VRELQLTLAQKEQEI---LELRETQQRN-NLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
+ L+ L E + + +E DL L QT+ V+ L+E +
Sbjct: 2152 LERLQAALRQTEAR------------EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQA 2199
Query: 961 NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK--KLMEVEKEKQEL 1018
+V + + L++ L ++ E+ R + +AE ++ E+ +L EV + E
Sbjct: 2200 SVLERDSEQQRLQDELELTRRALEKERLH-SPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258
Query: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL-SNEQQARRDCQEQAKIAVE 1077
D +S Q+L L++ ++ ++ + + LQR + L S +Q R+ ++ + A+
Sbjct: 2259 SPDGMEK-QSWRQRLEHLQQAVARLEID-RSRLQRHNVQLRSTLEQVERERRKLKREAMR 2316
Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
A E+ A Q + Q + A L++ E LL+ + + E +++
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK-----EVVLLQAQLTLERKQK- 2370
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
+D +++ +L + L + ++ A+V E L+ SL++ S +L
Sbjct: 2371 -QDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL 2429
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 237 bits (605), Expect = 9e-62
Identities = 345/1721 (20%), Positives = 759/1721 (44%), Gaps = 254/1721 (14%)
Query: 9 LERTELNKLPKSV-QNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ-E 66
L E N K + Q +E L +++ D L +E+ + E E+ +++++ + E
Sbjct: 479 LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFE 538
Query: 67 RLVNETRECQSLRL--ELEKLNNQLKALTEKNKELEIAQDRNIAI----QSQFTRTKEEL 120
L +T++ Q ++L E+ L N +K N++LE + + + Q + +E +
Sbjct: 539 ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI 598
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
+++K + I+ + LS LE + ED K++ + L ++ T + + + L++ ++ +K +
Sbjct: 599 DSQKLENIKMD--LSYSLESI-EDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKM 655
Query: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
K L + + + ++L+ K + L +E L++ E+++L +
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE-----------LQSAFNEITKLTSLI 704
Query: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
+G + +E +T L++ ++ E E+ I LS L KS + E
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV---ILLSEL-KSLPSEVERLR 760
Query: 301 NELTRAVEELH-------KLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
E+ EELH KL E +Q L E+ ++KD + ++E
Sbjct: 761 KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ-SNYKSTDQEF 819
Query: 354 ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEK 413
+N L ++K ++ EE + + K K A ++T+ ++
Sbjct: 820 QNFKTLHMDFEQKYKMVLEEN----ERMNQEIVNLSKEAQKFDSSLGA-LKTELSYKTQE 874
Query: 414 LENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD 473
L+ K + + E + E+E L+ + + ++ ++ KL+Q ++E++ L ++ D
Sbjct: 875 LQEK--TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
Query: 474 --KANKQSSVLERDNRRMEIQVK-----DLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
K ++S +ERD + +I D +Q+R L L++ +E +
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ--------HQETINTLK 984
Query: 527 SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS----SKITELQLK 582
S SE +S++L N E + + Q+ +V + + + + Q T+ ++I E Q K
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Query: 583 LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
+ S + E +L+ Q+++S++ +++ + L + + I + +++ L
Sbjct: 1045 IFSLIQEKNELQ-------QMLESVIAEKEQLKTDLKENIEMTI----ENQEELRLLGDE 1093
Query: 643 KRPSTSQTVSTPAPVPVIESTEAIEAKAALKQ----LQEIFENYKKEKAENEKIQNEQLE 698
+ + E AI+ + L + L E+ E K EK++ + + +QL
Sbjct: 1094 LKKQQE--------IVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLL 1144
Query: 699 KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
+QE++++++ + +I L K E+ +++E R E+ N + + K+ +
Sbjct: 1145 NVQEEMSEMQKKINEIEN-LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203
Query: 759 IINTMTQDLRGANEKLA--VAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL 816
++ + + + L + E+ A L+ KE LK++ + L + +E
Sbjct: 1204 VLKELQKSFETERDHLRGYIREIEATGLQT-KEELKIAHIHLKEHQE------------- 1249
Query: 817 TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
TI + +T Q +++Q + E SH K L+ E+ H + +LL
Sbjct: 1250 ----TIDELRRSVSEKTAQIINTQ----DLEKSHTK--LQEEIPVLHE-----EQELLPN 1294
Query: 877 KRQLDTETNLHLNTKELL--KNAQKEIATLKQ-HLSNMEVQVASQSSQRTGKGQPSNKED 933
+++ +ET +N ELL ++ K+ TL + + + + Q SQ K +++
Sbjct: 1295 VKEV-SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDN 1353
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN---KEKQVTEEVRKNI 990
+ + L +Q LKE ++ + + +++ Q+ E+SLN K+ + T+ V +
Sbjct: 1354 LKTIKEALEVKHDQ---LKEHIRETLAKIQESQS---KQEQSLNMKEKDNETTKIVSEME 1407
Query: 991 EVRLKESAEFQTQLE-----KKLME-------VEKEKQELQDDKRRAIESMEQQLSELKK 1038
+ + K+SA + ++E K+L E V KEK +LQ + ++S QL E K
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR-LQEVLQSESDQLKENIK 1466
Query: 1039 TLSSVQNEVQEALQRASTALSNEQQARRDC-----QEQAKIAV----------EAQNK-- 1081
+ + E +E L+ A L +++ + +++ +I+ + QNK
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 1082 --YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
YE+E + + +Q ++ + R+ + Q ES++LE +E +
Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ---- 1582
Query: 1140 DEVSKCVCRCEDLEKQNRLLH---DQIEKLSDKVVASVKEGVQGPLN-VSLSEEGKSQEQ 1195
+E+ + E++++ L DQ+++ + ++VA +KE + + ++ ++QE+
Sbjct: 1583 EEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEK 1642
Query: 1196 ILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKT 1255
+ EI ++ + E + E + E++R Q +L L+E++ S+ ER+ ++ +T
Sbjct: 1643 MCEI-EHLKEQFETQKLNLENIETENIRLTQ---ILHENLEEMR-SVTKERDDLRSVEET 1697
Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILP----LQEAN 1311
+ + +K+ + + K +EE + + L++ Q + KL + +
Sbjct: 1698 LKVERDQLKENLRETITRDLEK--QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755
Query: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
+L + L+A+ ++E+++ + HL QQ+ D + R ++SEK
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELR---IAHMHLKEQQETID--KLRGIVSEK---------- 1800
Query: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI 1431
T+++ ++ ++ SNA L Q IQ LK + +++ T K+ + + Q+KV +
Sbjct: 1801 TDKLSNMQKDLENSNAKL---QEKIQELKANEHQLITLKKDVN--------ETQKKVSEM 1849
Query: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
Q+KK ++K Q + + ++ Q+ H +++EM+ + + + +
Sbjct: 1850 EQLKK----------QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899
Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
+L+ + + L+++L +ET+AR+L+ +Q EL R ++ ++LR++I+EK
Sbjct: 1900 TLKLERDQLKESL--QETKARDLE-----IQQELKTARMLSKEHKETVDKLREKISEK-- 1950
Query: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRIS 1611
++ LD+ KDEL +I L+ + E ++
Sbjct: 1951 --------------------------TIQISDIQKDLDKSKDELQKKIQELQKK-ELQLL 1983
Query: 1612 RLERELREHQER--HLEQRDEPQEPSNKVPEQQRQITLKTT 1650
R++ ++ ++ +EQ + E N + R + T
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Score = 206 bits (525), Expect = 2e-52
Identities = 369/1812 (20%), Positives = 774/1812 (42%), Gaps = 265/1812 (14%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
Q +ER E + + +Q LE+ Q E D LK E ++E +Q +I H
Sbjct: 904 QTVER-EKTLITEKLQQTLEEVKTLTQ-EKDDLKQLQESLQIERDQLKSDI-----HDTV 956
Query: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
+ +T+E LR LE L + + ++ RN+ ++ TK+E + +
Sbjct: 957 NMNIDTQE--QLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014
Query: 127 LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
+ + + ++ + LT DVK NE +++ +Q K +ELQ SV +++L+ +
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKD-NEIIEQQRKIFSLIQEK-NELQQMLESVIAEKEQLKTD 1072
Query: 187 KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE-EVS----RLEEQMN 241
+ EL+ DEL +K EI+ + N KKE E+S RL E
Sbjct: 1073 LKENIEMTIENQEELRLLGDEL-----KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASME--EKFHNEL-NAHIKLSNLYKSAADDSEA 298
LK ++ LQ+ + LL +E E Q + E NEL N + L ++ + ++
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 299 --KSNELTRAVEELHKLLKEAGEANKAIQDHL----LEVE----QSKDQME------KEM 342
++ E +++ + K+LKE ++ + +DHL E+E Q+K++++ KE
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 343 LEKIGRLEK-------ELENANDL-LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK 394
E I L + ++ N DL S TK + I E + P V++ + M
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE-TQETMN 1306
Query: 395 LTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASL 454
EL T+D L ++E +R+ L+E +E + + L ++R+ + ++A+
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLR--LNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 455 SVKLEQAMKE-IQRLQEDTDKANKQSSVLERDNR-------------------RMEIQVK 494
+L++ ++E + ++QE K + ++ E+DN R+EI++
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 495 DLSQQIR---------------------VLLMELEEARGN-------HVIRDEEVSSAD- 525
LS++++ VL E ++ + N H+ +EE+ A
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 526 -ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE-----LGETREREEQETTSSKITEL 579
+ E I++ V+ E Q+ L A+ + + E E+EEQ +I+E+
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ-FNIKQISEV 1543
Query: 580 QLKLESALTELEQLRKSRQHQMQLVDS--------IVRQRDMYRILLSQTTGVAIPLHAS 631
Q K+ + L + ++ RK++ +Q ++S + ++ +I++ + + A
Sbjct: 1544 QEKV-NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 632 SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEK 691
++ L K S ++ T E + + +++ + E ++ +K E
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 692 IQNEQL-------EKLQE------QVTDLRSQNTKISTQLDFASK--RYEMLQDNVEGYR 736
I+ E + E L+E + DLRS + + D + R + +D +
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 737 REITSLH-----ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML 791
+I +H E KL ++ I+ M +DL +N+ L +A++LK ++E L
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL-----KAQDLKIQEE-L 1776
Query: 792 KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHL 851
+++ + L +Q+E++ + + L +Q LE S + ++++ +++ EH++ L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI-QELKANEHQLITL 1835
Query: 852 KKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM 911
KK + NE +++ + L Q+ D L +LN + L +E+ ++ + N+
Sbjct: 1836 KKDV-NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 912 EVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS 971
+ + + K + D L L++T+ + ++++ LKT+ ++++ V
Sbjct: 1895 R------------RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK 1942
Query: 972 LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQE--LQDDKRRAIESM 1029
L E ++++ +++K+++ E + +L+KK +++ + K++ + K +E +
Sbjct: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQL 2002
Query: 1030 EQQLSELKKTLSSVQ-------NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082
++Q ++ SV+ ++ E+L+ + RR +E K+ +
Sbjct: 2003 KKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR-IKESLKMERDQFIAT 2061
Query: 1083 ERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
RE++ A D + Q K + ++ +QHL E+ ++ S++ E + E D+
Sbjct: 2062 LREMI--ARDRQNHQ-VKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE-----MDDH 2113
Query: 1143 SKCVCRCE-DLEKQNRLLHD---------QIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192
+C+ R DLEK+ + + L K + + Q ++ K
Sbjct: 2114 YECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ-RCSMEFHRIMKK 2172
Query: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252
+ +L + I+ E+ + +FE+ ++ + ++ + + + LQ+ D + E +++
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232
Query: 1253 AKTMAQHEELMK----------KTETMNVVMETNKMLR--EEKERLEQDLQQMQAKVRK- 1299
EE++K KTE V+ +M + EE D+++++ ++K
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
Query: 1300 ----------LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQ---- 1345
I+ + + E E+S + E E+D+K K +N+ L
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDLKSLKEKNEKLFKNYQTL 2349
Query: 1346 --------QKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQ 1397
Q +P T++ + V ++ Q TE+I L+ + + S + ++ I
Sbjct: 2350 KTSLASGAQVNPTTQDNK----NPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Query: 1398 SLKEDLNKVRTEKETIQKDLDAKI-IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM 1456
++++L + D+ AK+ + E K + + K E ++ QDKV
Sbjct: 2406 KMQKELE--------VTNDIIAKLQAKVHESNKCLEKTK----------ETIQVLQDKV- 2446
Query: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
A + ++E+ + +M+ +K L + + +K E ++ + T+ Q+
Sbjct: 2447 ---ALGAKPYKEE-IEDLKMKLVKIDLEKMK-NAKEFEKEISATKATV--------EYQK 2493
Query: 1517 QTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI-VAAKSKIAHLAGVKDQLT 1575
+ ++L E R Q QD + E Q + K + +K L +L
Sbjct: 2494 EVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLE 2553
Query: 1576 KENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPS 1635
KE +LKQ+N L +QK+EL L ++ + + ER L+ + + + P+ P
Sbjct: 2554 KEISKLKQQNEQLIKQKNELLSNNQHLSNEVK---TWKERTLKREAHKQVTCENSPKSPK 2610
Query: 1636 -NKVPEQQRQIT 1646
+++QIT
Sbjct: 2611 VTGTASKKKQIT 2622
Score = 202 bits (513), Expect = 4e-51
Identities = 365/1764 (20%), Positives = 744/1764 (42%), Gaps = 286/1764 (16%)
Query: 24 KLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSLRL 80
K + LA QS + FK ++ EQ+Y + + + +VN ++E Q
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859
Query: 81 ELEKLNNQL----KALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
L L +L + L EK +E++ + ++ Q L+ +R+ E+L Q
Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919
Query: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTW 196
L E+VK L ++ + + LQ++ D+L++ +H
Sbjct: 920 TL----EEVKTLTQEKDDLKQLQESLQIERDQLKSD-----------------IHD---- 954
Query: 197 LNTELKTKTDELLALGREKGNEILELKCNLENK-KEEVSR-LEEQMNGLKTSNEHLQKHV 254
+ T E L E + E L++K EEVSR L + N +T +E QK V
Sbjct: 955 -TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
Query: 255 EDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL 314
+++ +E K L A + K NE+ ++ L+
Sbjct: 1014 ---------GIDKKQDLEAKNTQTLTA---------------DVKDNEIIEQQRKIFSLI 1049
Query: 315 KEAGEANKAIQDHLLEVEQSKDQMEK------EMLEKIGRLEKELENANDLLSATKRKGA 368
+E E + ++ + E EQ K +++ E E++ L EL+ +++ A ++ A
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV-AQEKNHA 1108
Query: 369 ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVK 428
I E EL+ A V + KL E E Q QLL + E + K ++EI
Sbjct: 1109 IKKEGELSRTCDRLAEVEE------KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162
Query: 429 -EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD--KANKQSSVLERD 485
+ E K L + E ER + L+ KL + +E++ + ++ K ++S ERD
Sbjct: 1163 LKNELKNKELTLEHMETERLE-----LAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217
Query: 486 NRR---MEIQVKDL--SQQIRVLLMELEEARG--NHVIRDEEVSSADISSSSEVISQHLV 538
+ R EI+ L +++++ + L+E + + + R +A I ++ ++ H
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277
Query: 539 SYRNIEELQQQNQRLLVALRELGETRER-------EEQETTSSKITELQLKLESALTELE 591
I L ++ Q LL ++E+ ET+E EQ TT T ++++E
Sbjct: 1278 LQEEIPVLHEE-QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL----- 1331
Query: 592 QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTV 651
+L + Q + + S+ ++RD +L + A K +
Sbjct: 1332 RLNEKFQESQEEIKSLTKERD-------------------NLKTIKEALEVKHDQLKEH- 1371
Query: 652 STPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQN 711
I T A ++ KQ Q + N K++ E KI +E EQ S
Sbjct: 1372 --------IRETLAKIQESQSKQEQSL--NMKEKDNETTKIVSE-----MEQFKPKDSAL 1416
Query: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGAN 771
+I ++ SKR + D ++ +E L + L + + + ++ I +
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE 1476
Query: 772 EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT-IQGILERSE 830
E+L VA LK+++E + V LS++ + Q+ + LQ IQ I E+ E
Sbjct: 1477 EELKVAHC---CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE 1533
Query: 831 TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD-TKRQLDTETNLHLN 889
Q QI +++ +++ LK+ E+ + + + ++++ ++L+ T R +++ + +
Sbjct: 1534 ----QFNIKQISEVQEKVNELKQFKEHR-KAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 890 TKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL-VSQLRQTEE-- 946
KE ++E+ +++ L Q+ + + K + S +++ L ++ + +T+E
Sbjct: 1589 IKE-----KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 947 -QVNDLKERLKTSTSNVEQYQA----MVTSLEESLNKEKQVTEE--VRKNIEVRLKESAE 999
++ LKE+ +T N+E + + L E+L + + VT+E +++E LK +
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703
Query: 1000 FQTQLEKKLMEV---EKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV---QEALQR 1053
QL++ L E + EKQE ++ ++ + +L+ +S NE+ Q+ L+
Sbjct: 1704 ---QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA-AKEQVSKMASVRQH 1112
++ AL + QE+ +IA L ++ L+ E+ K++++++
Sbjct: 1761 SNDALKAQD---LKIQEELRIA-------HMHLKEQQETIDKLRGIVSEKTDKLSNMQKD 1810
Query: 1113 LEETTQKAESQLLECKASWEERERMLKD--EVSKCVCRCEDLEKQ--------------- 1155
LE + K + ++ E KA+ + + KD E K V E L+KQ
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Query: 1156 ---NRLLHDQIEKLSDKV-----VASVKEGV---QGPLNVSLSEEGKSQ---EQILEILR 1201
+ LH+ +E++ + + V+E + + L SL E +Q L+ R
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 1202 FIRRE---------KEIAETRFEVAQVESLRYRQRVELLER--ELQELQDSLNAEREKVQ 1250
+ +E ++I+E +++ ++ + + EL ++ ELQ+ + L +E V
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVN 1990
Query: 1251 VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEA 1310
++ K + + E+L K+ E N+ M++ +R + +L + L + ++R + + L+
Sbjct: 1991 MSHKKINEMEQLKKQFEAQNLSMQS---VRMDNFQLTKKLHESLEEIRIVAKERDELRRI 2047
Query: 1311 NAELS-EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
L E+ + ++++ D R H V +K +LLS+ + H +
Sbjct: 2048 KESLKMERDQFIATLREMIARD------RQNHQVKPEK--------RLLSDGQQHL--TE 2091
Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNK-VRTEKE---TIQKDLDAKIIDIQ 1425
L E+ R+K E+ + + + ++ + L DL K + +KE ++ +L + +
Sbjct: 2092 SLREKCSRIK-ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK 2150
Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
K T ++ + ++LK V + +EQH S+ + + + +++
Sbjct: 2151 HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK-------EEQHESINKFE--MDFIDE 2201
Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
E K K L ++++LQ+ E R+L +L Q++ E++ +
Sbjct: 2202 VE-KQKELLIKIQHLQQDCDVPSRELRDL------------KLNQNMD---LHIEEILKD 2245
Query: 1546 ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL---DVRITAL 1602
+E E + K++ + + ++T+ EE +++ K+ + + RI +
Sbjct: 2246 FSESE------FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQV 2299
Query: 1603 KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI-----TLKTTPASGERG 1657
+ + RI + E E +ER E ++ + E+ ++ TLKT+ ASG +
Sbjct: 2300 NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQV 2359
Query: 1658 IASTSDPPTANIKPTPVVSTPSKV 1681
+T D ++ T K+
Sbjct: 2360 NPTTQDNKNPHVTSRATQLTTEKI 2383
Score = 76.6 bits (187), Expect = 3e-13
Identities = 152/777 (19%), Positives = 302/777 (38%), Gaps = 164/777 (21%)
Query: 1006 KKLMEVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQR-----ASTAL 1058
K++M+++K+ +E+ + R +Q QL E K L VQNE E L R +S L
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409
Query: 1059 SNEQQARRDCQEQ---AKIAVEAQNKYERELML--------HAADVEALQAAKEQVSKMA 1107
E +A+R + KI + Y + + H + L+ E V +
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES 469
Query: 1108 SVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLL-HDQIEKL 1166
V + +T + E W ++L E + + N +L ++Q+
Sbjct: 470 DVFSNTLDTLSEIE---------WNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++ +KE K+ E L ++ + + E++ +++L
Sbjct: 521 KEEMELKLKE--------------KNDLDEFEALERKTKKDQEMQLIHEISNLKNL---- 562
Query: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR--EEKE 1284
V+ E Q+L++ L+++ E ++ + + +E + + N+ M+ + L E+ +
Sbjct: 563 -VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621
Query: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
+++Q L + + + L+ N EL EK L K +E D++ ++++ +
Sbjct: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Q D + K +Q EI +L SL + + + +DL
Sbjct: 682 MQVDLE---------------KELQSAFNEITKL--------TSLIDGK-----VPKDL- 712
Query: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
+L+ KI D+Q+++ + + R ELK+ +V +
Sbjct: 713 -------LCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD 765
Query: 1465 DHQEQHVSVQEMQEL---------------------KETLNQAETKSKSLESQVENL--- 1500
+E H+ E +L K+ L ++ KS + + +N
Sbjct: 766 KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825
Query: 1501 --------QKTLSEKE----------TEARNLQEQTVQLQSELSRLRQDLQDRT------ 1536
+ L E E EA+ L++ELS Q+LQ++T
Sbjct: 826 HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER 885
Query: 1537 -TQEEQLRQQITEKEEKTRKAIVAAKSKIAH-----LAGVKDQLTKENEELKQRNGALDQ 1590
+ EQL++Q+ E + T + + K+ I L VK LT+E ++LKQ +L
Sbjct: 886 LNEMEQLKEQL-ENRDSTLQTVEREKTLITEKLQQTLEEVK-TLTQEKDDLKQLQESLQI 943
Query: 1591 QKDEL--DVRIT-------------ALKS--QYEGRISRLERELREHQERHLEQRDEPQE 1633
++D+L D+ T AL+S Q++ I+ L+ ++ E R+L + E
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 1634 PSNKVPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNK 1690
++ ++ I K A + TA++K ++ K+ + N+
Sbjct: 1004 TKDEFQQKMVGIDKKQDLE------AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Score = 64.3 bits (155), Expect = 1e-09
Identities = 139/720 (19%), Positives = 285/720 (39%), Gaps = 120/720 (16%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRH----EKFKVESEQQYF--EIEKRLSH 63
ER EL ++ +S++ + ++F+A + I + H EK + QQ+ + ++ S
Sbjct: 2040 ERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSR 2099
Query: 64 SQERL-----VNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
+E L +++ EC L +L+ L+ E KEL + N+++ T+ E
Sbjct: 2100 IKELLKRYSEMDDHYEC------LNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153
Query: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-DVSVK 177
+L + R+ ++L+Y+ V ++ E+ ES K E+ +DE++ ++ +K
Sbjct: 2154 KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES-INKFEMDF-IDEVEKQKELLIK 2211
Query: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEIL--ELKCNLENKKEEVSR 235
+ + + + ++ LN + +E+L E + E + L N+KE
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQF 2271
Query: 236 LEEQMN----------GLKTSNEHL-------QKHVEDLLTKLKEAKEQQASMEEKFHNE 278
LEE +N G++ N+ + + ++ + E +E+ A++ +++ +
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQD 2331
Query: 279 LNA----HIKLSNLYKSAADD--SEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
L + + KL Y++ S A+ N T+ + H + + I++ +
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391
Query: 333 QSKDQ-MEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
++K+ M KE KI +++KELE ND+++ + K S + L T + V
Sbjct: 2392 EAKESAMHKE--SKIIKMQKELEVTNDIIAKLQAK-VHESNKCLEKTKETIQVLQDKVAL 2448
Query: 392 GMKLTELYNAYVETQDQLL----LEKLEN-KRINKYLDEIVKEVEAKAPILKRQREEYER 446
G K Y +E L LEK++N K K + VE + +++ RE R
Sbjct: 2449 GAKP---YKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
Query: 447 AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
+Q+A ++ + E TD + + Q + L+++
Sbjct: 2506 SQQA------------QDTSVISEHTDPQPSNKPLTCGGG-------SGIVQNTKALILK 2546
Query: 507 LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL------ 560
S+H+ + I +L+QQN++L+ EL
Sbjct: 2547 ---------------------------SEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH 2579
Query: 561 ---------GETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR 611
T +RE + + + + K+ ++ +Q+ S+ + L D + ++
Sbjct: 2580 LSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKES 2639
Query: 612 DMYRILLSQTTGVAIPLHASSLDDVSLASTP--KRPSTSQTVSTPAPVPVIESTEAIEAK 669
S++ + P D+ SL P + S P P + E K
Sbjct: 2640 PKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECK 2699
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 221 bits (563), Expect = 7e-57
Identities = 344/1721 (19%), Positives = 709/1721 (41%), Gaps = 174/1721 (10%)
Query: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
++ L R EL +L + + + ++ ++Q + F+ E E+++ + E L +
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRV---------FQEEEEKEWRKRETVLRKEE 257
Query: 66 ERLVNETRECQ-SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEK 124
E+L E + Q L+ E E+L + + ++ E Q + + + Q R +EE E+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 125 RDLIR-TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRL 183
++ R ER Q+ E + ++R E+ +E + + + + ++ + + RE++L
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 184 EQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGL 243
+E++L Q +L+ + L RE+ +L+ + ++E+ R E+Q+
Sbjct: 378 RREQQLRREQQLRREQQLRREQQ----LRREQ-----QLRREQQLRREQQLRREQQLRRE 428
Query: 244 KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
+ H QKH ++ + + ++++ K E H + + D E +
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
+ EE + +E E + ++ K Q E+E L++ R E++L +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE----- 543
Query: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK---RIN 420
+R+ +L EE + + + +L E + Q L + E + R+
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSS 480
+ E +++ E + LKR+ E ER Q+ + S EQ + Q+L+ + + +Q
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKS----EEQEERRQQQLRREQQERREQRL 659
Query: 481 VLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSY 540
E + R+E ++K E EE R R++E++ + + E I + +
Sbjct: 660 KREEEEERLEQRLK----------REHEEER-----REQELAEEEQEQARERIKSRIPKW 704
Query: 541 R---NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSR 597
+ E +Q++ ++ G+ R +E++E + +ELQ + E +Q + R
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 598 QH---QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP----KRPSTSQT 650
+ Q Q + R R L A P K Q
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 651 VSTPAPVPVIESTEAIEAKAALKQLQE----IFENYKKEKAENEKIQNEQLEKLQEQVTD 706
+ +E E ++ + +QLQE + E+ ++ +++ ++ + +L+E+
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766
R + K ++LQ+ E +RE ER ++ ++QEQ ++
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQRE-----EREKR-----RRQEQERQYREEE 934
Query: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGIL 826
E+ + E R + ++E+E + +L Q+ E LL E+ +
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR------------- 981
Query: 827 ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
R E E K R ++++ E ++ +++ E + ++Q + + +
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 887 HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
L +E ++E+ ++ L E + + + Q +E++ QL + E
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQEL---ERQYRKEEELQQEEEQLLREEP 1098
Query: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
+ +ER + E Q L E K + R+ +E + +E E Q Q E+
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRR------RQELERQYREEEEVQ-QEEE 1151
Query: 1007 KLMEVEKEKQELQDDKR--RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
+L+ E EK+ Q+ +R R E ++Q+ +L + + + +E R L +++
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 1065 RRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR----------QHLE 1114
+R E + ++ Q + E+E + V EQ ++ + QHL
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
Q+ + + + + W++R+R +E + + R E E + R Q EK +
Sbjct: 1272 GEQQERDRE--QERRRWQQRDRHFPEE--EQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFE--------VAQVESLRYRQ 1226
K Q EE QE+ + LR R+++ E + + + LR ++
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387
Query: 1227 RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKER- 1285
R +E Q+L+ ++ + K + ++L ++ E ++ R+E+ER
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK 1447
Query: 1286 -LEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
LE++ Q Q + RK + LQE + + + ++K LEE+ + +
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ---ERDRKFLEEEQQLRRQERDRKFR 1504
Query: 1345 QQKDPDTEEYRKLL-SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED- 1402
+Q+ E RK L E+++H QQ + + + ++ R Q+ + +E+
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHR---QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 1403 -LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGR-----RYKTQYEELKAQQDKVM 1456
L + R E++ +++ D K ++KV+ Q +K R + ++L+ ++D+
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 1457 ETSAQSSGDHQEQHVSVQE-------------MQELKETLNQAETKSKSLESQV------ 1497
Q + +EQ + QE QE ++ L + E Q+
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 1498 -----ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
+ + E+E + R + + LQ E RQ+L+ + +EEQLRQ+ TE+E+
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE-TEQEQL 1740
Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ-KDELDVR----ITALKSQYE 1607
R+ KI ++QL E EE + R D++ ++E +R L+SQ
Sbjct: 1741 RRQ---ERYRKILE----EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793
Query: 1608 GRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLK 1648
R R E +LR+ +E EQ+ PQ+ K ++ Q+ L+
Sbjct: 1794 DRKFREEEQLRQERE---EQQLRPQQRDGKYRWEEEQLQLE 1831
Score = 208 bits (529), Expect = 6e-53
Identities = 365/1805 (20%), Positives = 747/1805 (41%), Gaps = 199/1805 (11%)
Query: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGL-----KGRHEK-----------FKVESEQQY 54
R E +L ++ E+F ++Q L KGR EK F+ E E+++
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 55 FEIEKRLSHSQERLVNETRECQ-SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQF 113
+ E L +E+L E + Q L+ E E+L + + ++ E Q + + + Q
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 114 TRTKEELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS 172
R +EE E+++ R ER Q+ E + ++R E+ +E + + + + ++
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 173 DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232
+ + RE++L +E++L Q +L+ + L RE+ +L+ + ++E+
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQ----LRREQ-----QLRREQQLRREQ 417
Query: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
R E+Q+ + H QKH ++ + + ++++ K E H + +
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
D E + + EE + +E E + ++ K Q E+E L++ R E++
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 353 LENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLE 412
L + +R+ +L EE + + + +L E + Q L
Sbjct: 538 LRREQE-----ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 413 KLENK---RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
+ E + R+ + E +++ E + LKR+ E ER Q+ + S EQ + Q+L+
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLR 648
Query: 470 EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ + +Q E + R+E ++K E EE R R++E++ + +
Sbjct: 649 REQQERREQRLKREEEEERLEQRLK----------REHEEER-----REQELAEEEQEQA 693
Query: 530 SEVISQHLVSYRNIEELQQQNQRLLVALR---ELGETREREEQETTSSKITELQLKLESA 586
E I + ++ E + ++ V R + G+ R +E++E + +ELQ + E
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 587 LTELEQLRKSRQH---QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP- 642
+Q + R+ Q Q + R R L A P
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 643 ---KRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
K Q + +E E ++ + +QLQE + ++++ + + +K
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 700 LQEQVTDLRSQN-----TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
+ Q+ + R + K + Q + K ++LQ+ E +RE R Q+ +
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQ-EQLRKEQQLLQEEEEELQREERE-KRRRQEQERQYR 931
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
++EQ+ Q LR EK E R +K+K++ + E L ++ E ++R +
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQE-RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 815 LLTN-LQTIQGILERSETETKQRLS--SQIEKLEHEISHLKKKLENEVEQRHTLTRNL-- 869
LQ + L R E E ++R Q K + ++ L E E+R R
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 870 --DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
+ +L + QL E +EL + +KE L+Q + + + ++ + Q
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQERERQ 1109
Query: 928 PSNKEDVDDLVSQLRQTEEQVNDLKE--RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
+E++ QL + E + +E R V+Q + + E + +++ +
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169
Query: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEK---EKQELQDDKRRAIESMEQQLSELK----- 1037
R+ E++ +E + + EK+ E E+ E++ELQ KR+ E Q S+LK
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 1038 -KTLSSVQNEV------QEALQRASTALSNEQQARRDCQ----EQAKIAVEAQNKYEREL 1086
K + N+V E ++ + ++Q+++D Q EQ + E + + ++
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
H + E L+ +++ +K + E+ + E E K +E +R ++E
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER---EEKRRRQETDRKFREEEQLL- 1345
Query: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206
++ E+Q ++ K ++ + ++G + L EE + + Q E +F++ E
Sbjct: 1346 ---QEREEQPLRRQERDRKFREEELRHQEQGRK-----FLEEEQRLRRQERE-RKFLKEE 1396
Query: 1207 KEIA--ETRFEVAQVESLRYRQRVELLERE------LQELQDSLNAEREKVQVTAKTMAQ 1258
+++ E ++ Q ++R+ + L R+ +E Q ERE+ + + +
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456
Query: 1259 HEELMKKTETMNVVMETNK--MLREEKER--LEQDLQ-QMQAKVRKLELDILPLQEANAE 1313
E K E ++ E + + R+E++R LE++ Q + Q + RK L QE +
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516
Query: 1314 LSEKSGML---QAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ 1370
E+ L Q ++K L+E+ + + Q +D E +L E+E Q+
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 1371 LTEEIGRLKAEIARSNAS---LTNNQNLI-----QSLKEDLNKVRTEKETIQKDLDAKII 1422
+ + ++ R + + Q L Q L+++ ++ E E + ++ + + +
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE----MQE 1478
QE+ + + + RR + + ++L+ +D+ Q + +EQ + QE +E
Sbjct: 1637 HRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 1479 LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQ---------------- 1522
++ L + E + K L+ + + ++ L K E L+++T Q Q
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 1523 ---SELSRLRQDLQDRT-TQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
E +LR+ +DR +EEQLRQ+ E++ +++++ + + +QL +E
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE--------EQLRQER 1807
Query: 1579 EELK----QRNGALDQQKDELDVR--------------------ITALKSQYEGRISRLE 1614
EE + QR+G ++++L + T KS+ E + E
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQI-TLKTTPASGERGIASTSDPPTANIKPTP 1673
E + QER + R+E K ++ RQ+ +K+ G + +P T P
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL---EPGTHQFASVP 1924
Query: 1674 VVSTP 1678
V S+P
Sbjct: 1925 VRSSP 1929
Score = 185 bits (469), Expect = 5e-46
Identities = 361/1714 (21%), Positives = 718/1714 (41%), Gaps = 222/1714 (12%)
Query: 31 DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR---------------EC 75
D+Q E + + R +K + E E++ E E++ S QERL R E
Sbjct: 126 DRQLEEEPGQRRRQK-RQEQERELAEGEEQ-SEKQERLEQRDRQRRDEELWRQRQEWQER 183
Query: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIA-IQSQFTRTKEELEAEKRDLIRTNERL 134
+ R E E+L + TE+ + E + R + ++ + K++ E++D + E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-- 241
Query: 135 SQELEYLTED--VKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHS 192
+E E+ + +++ EKL+E + Q +L E + ++ +E R E+++E
Sbjct: 242 -EEKEWRKRETVLRKEEEKLQEEEPQR---QRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 193 QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252
Q +L+ K +E +E+ E E + E ++E+ R E++ + + L++
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE----ERREQQLRR 353
Query: 253 HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
E+ + + +EQ+ EE+ +L +L + + + +L R + +
Sbjct: 354 EQEEERREQQLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410
Query: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE 372
+ + Q E E+ + + + E + RL++E E D L E
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR---------E 461
Query: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL----DEIVK 428
EE TE + E + Q L E +R ++L +E +
Sbjct: 462 EE---------------------TERHEQ--ERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 429 EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
+ E + L+R++EE + +L+Q ++ Q+L+ + ++ +Q +L+R+
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ--LLKREEE- 555
Query: 489 MEIQVKDLSQQIRV--LLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEEL 546
K L Q+ R L E EE R + R+EE + E + + +E L
Sbjct: 556 -----KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 547 QQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDS 606
+Q+ +R RE E R++ + + Q +L E + R R+ + + ++
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Query: 607 IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI 666
+++ H + LA + + + S +P +
Sbjct: 671 RLKRE-----------------HEEERREQELAEEEQEQARERIKSR---IPKWQWQLES 710
Query: 667 EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
EA A ++ + K E ++ + EQ EK + + ++L+ Q + + + + E
Sbjct: 711 EADARQSKVYS-----RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR---QQQEEE 762
Query: 727 MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKK 786
+D ++ E S R Q+L+A +EQ + + R E+ + E + ++
Sbjct: 763 QRRDFTWQWQAEEKSERGR-QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Query: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
+ + E++ ++ E L +R Q LQ + L+ + + + + +K
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQ-----QLQEEEDGLQEDQERRRSQEQRRDQKWRW 876
Query: 847 EISHLKKKLENEVEQRHTLTRNLDVQ-LLDTKRQLDTETNLHLNTKELLKNAQKEIATL- 904
++ +K+ +RHTL +Q L ++QL E L +E K ++E
Sbjct: 877 QLEEERKR------RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 905 --KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV---NDLKERLKTST 959
++ L E Q+ + ++ + + + D +L+Q EEQ+ K R +
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKD---KKLQQKEEQLLGEEPEKRRRQERE 987
Query: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
+ + + E+ L +E++ + R+ E + ++ E Q Q E++L+ E+EK+ LQ
Sbjct: 988 KKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQ-QEEEQLLREEREKRRLQ 1044
Query: 1020 DDKRRAIE------SMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE-------Q 1062
+ +R+ E EQ L E ++T + E Q E LQ+ L E Q
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 1063 QARRDCQEQAK--------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASV---RQ 1111
+ R C+E+ + + E + + +EL + E +Q +EQ+ + RQ
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 1112 HL------EETTQKAESQLL--ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQI 1163
L EE Q+ E QLL E + +ERER ++E E+L++Q R +
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE--------EELQRQKRKQRYRD 1216
Query: 1164 E-KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI----LRFIRREKEIAETRFEVAQ 1218
E + SD E + + +G+ EQ ++ LR + ++++ E +
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276
Query: 1219 VESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE--LMKKTETMNVVMETN 1276
+ + R+R + +R E ++ L E +K +Q E+ L ++ E ET+
Sbjct: 1277 RDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 1277 KMLREEKERLEQDLQQ---MQAKVRKLELDILPLQEANAELSEKSGMLQAEKK----LLE 1329
+ REE++ L++ +Q Q + RK + L QE + E+ L+ +++ L E
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL 1389
E R + R Q L Q +D E + LS +E R ++ EE +++ + R L
Sbjct: 1396 EQQLRCQEREQQL-RQDRDRKFREEEQQLSRQE----RDRKFREEEQQVRRQ-ERERKFL 1449
Query: 1390 TNNQNLIQSL------KEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT 1443
Q L Q +E L + R E++ +++ D K ++ ++ Q+++ R K
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ------QLRRQERDRKF 1503
Query: 1444 QYEELKAQQ-DKVMETSAQSSGDHQEQHVSVQEMQELK-----ETLNQAETKSKSLESQV 1497
+ +EL++Q+ ++ Q Q Q +QE Q+L+ + Q + E Q+
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 1498 --ENLQKTLSEKETEAR-NLQEQTVQLQSELSRLRQDLQDRTTQE--EQLRQQITEKEEK 1552
E ++ LS +E + + L+EQ V+ Q + + +D Q QE +QLRQ+ K +
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS-QYEGRIS 1611
+ + + + H +D+ E E +R Q + + D + + EG
Sbjct: 1624 DEQLLQEREEQQLH-RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 1612 RLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
+L R+ R+ + R EQ+ QE K ++++Q+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Score = 143 bits (360), Expect = 2e-33
Identities = 205/1038 (19%), Positives = 452/1038 (43%), Gaps = 99/1038 (9%)
Query: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
E E E +A +QLQ + +E + E+++ +L +L+ + + + Q + F
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 721 ASKRYEMLQDNVEGYRREITSLHERN-QKLTATTQKQEQIINTMTQDLRGANEKLAVAEV 779
+ + + R+E L E Q+ +++EQ+ Q+LR ++ E
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE---EEQ 295
Query: 780 RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSS 839
+ + L++E+++ + E +Q+E +Q + Q + ++ E ++R
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERRE------QQEERREQQLRREQEERREQ 349
Query: 840 QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQK 899
Q+ + E E +++L E E+ + Q L ++QL E L +E ++
Sbjct: 350 QLRR-EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR---REQQLRREQ 405
Query: 900 EIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND-LKERLKTS 958
++ +Q +++ Q + + + K + + +L++ +E+ D LK +T
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 959 TSNVEQYQAMVTSLEESLNKEKQVT---EEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
E+ + + +E +E+ + EE R+ E R ++ Q + ++ ++ ++E+
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC-----QE 1070
+ LQ + R+ + + ++ E ++ L + E + +R L EQ+ RRD +E
Sbjct: 526 ERLQQ-RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
+ + ++ + + E L +VE L+ + + ++ EE ++ QLL+ +
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR-----EEPEEERRQQLLKSEEQ 639
Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEG 1190
E R++ L+ E + ++ RL ++ E+ ++ + E + ++ E+
Sbjct: 640 EERRQQQLRREQQE--------RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 1191 KSQEQI----------LEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
+++E+I LE R+ K + R + Q ++ E ELQ ++
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
+++ + + + +K+E + LRE++ER Q++A+ R+
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER------QLRAEERQQ 805
Query: 1301 -ELDILPLQEANAELSEKSGMLQAEKKLLEEDVK-RWKARNQHLVSQQKDPDTEEYRKLL 1358
E LP +E + + + E + LEE+ + + + R Q L ++ ++ R+
Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNA---SLTNNQNLIQSLKEDLNKVRTEKETIQK 1415
E+ K QL EE R + + A L Q L+Q +E+L + EK Q+
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 1416 DL-----DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM-----ETSAQSSGD 1465
+ ++ +E++ + K+ + + QY + K Q K E + +
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 1466 HQEQHVSVQEMQELKETLNQAETKSKSLES---------QVENLQKTLSEKETEARNLQE 1516
++++ +E+Q+ +E L + E + + + +++ ++ L +E E R LQE
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045
Query: 1517 QTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK 1576
+ Q + E ++LQ +EEQL + E+E + R+ + K L ++QL +
Sbjct: 1046 RERQYREE-----EELQQ---EEEQLLGE--ERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 1577 ENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQ--ERHLEQRDEPQEP 1634
E E ++R Q ++E +++ Q E ++ R ERE R Q ER + +E Q+
Sbjct: 1096 EEPEKRRRQERERQCREEEELQ------QEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 1635 SNKV----PEQQRQITLK 1648
++ PE++R+ L+
Sbjct: 1150 EEQLLREEPEKRRRQELE 1167
Score = 73.9 bits (180), Expect = 2e-12
Identities = 91/473 (19%), Positives = 205/473 (43%), Gaps = 49/473 (10%)
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L EE +++ E L RR++E + R+ R LE E + + E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEE-----------DQRRFEPRDRQLEEEPGQRRRQKRQE 143
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRK------ 1299
+E+ + ++ +E +++ + E + +E +ER E+ ++ Q + K
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 1300 -------LELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
++L L+ E ++ + ++ EE+ K W+ R L +++ E
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 1353 E--YRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
E ++ L E+E +++++ +E+ R + E + L Q L + +E+ + + E+
Sbjct: 264 EPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 1411 ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+++ + Q ++ ++ + + EE + QQ + + +EQ
Sbjct: 322 R-------------EQQERREQQEERREQQLRREQEERREQQ-----LRREQEEERREQQ 363
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+ ++ +E +E + E + + E Q+ Q+ E++ + QL+ E +LR+
Sbjct: 364 LRREQEEERREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRR 421
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q R QEE+ +Q E+E + ++ + + L ++ E E KQ+ DQ
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL-KRDQ 480
Query: 1591 QKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQR 1643
+++ + + + + + R E++LR QE EQR + QE ++ ++ R
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Score = 57.0 bits (136), Expect = 2e-07
Identities = 122/609 (20%), Positives = 238/609 (39%), Gaps = 77/609 (12%)
Query: 24 KLEKFLADQQSEIDGLKGRHEKFKVESEQ-------QYFEIEKRLSHSQERLVNETRECQ 76
K E+ L Q+ E + R KF+ E +Q + F E++ QER E Q
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 77 SLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL-IRTNERLS 135
LR E + + + L ++ +E ++ + +F +++L ++RD R E S
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQER---DRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 136 QELEY-LTEDVKRLNEKLKESNTTKGELQLKLDEL---QASDVSVKYREK-RLEQEKELL 190
QE E E+ ++L+ + ++ + E QL+ E + D K+RE+ +L QE+E
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE-- 1568
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Q + + K + +E +E+ + +E E+ R +E L+ +
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFME--------DEQQLRRQEGQQQLRQERDRK 1620
Query: 251 QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEEL 310
+ E LL +E +EQQ +E+ L +L + + ++ R E
Sbjct: 1621 FREDEQLL---QEREEQQLHRQERDRKFLEEEPQLRR-----QEREQQLRHDRDRKFREE 1672
Query: 311 HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAIL 370
+LL+E E Q+ + + + Q+ ++ E+ E++ +L + + +
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
E E Q+QL ++ R K L+E
Sbjct: 1733 QETE-------------------------------QEQLRRQE----RYRKILEEEQLRP 1757
Query: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
E + L+RQ ER +K ++ E+ ++++ + D ++ ER+ +++
Sbjct: 1758 EREEQQLRRQ----ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813
Query: 491 IQVKDLSQQIRVLLMELEEARGN-HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Q +D + ++LEE RD + + + ++ E + EE +++
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873
Query: 550 NQRLLVALRELGETREREEQETTS-SKITELQLKLESALTE--LEQLRKSRQHQMQLVDS 606
+R E +++EEQ +I + K L E Q L +
Sbjct: 1874 QERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEY 1933
Query: 607 IVRQRDMYR 615
I QR YR
Sbjct: 1934 IQEQRSQYR 1942
Score = 41.2 bits (95), Expect = 0.012
Identities = 38/194 (19%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
Q++G +E+ + L + Q E + + E + L++ ++ + R QE+ +
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRR-FEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 1521 LQSELSRLRQDLQ--DRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
E S ++ L+ DR ++E+L +Q E +E+ + A + ++ G + + +
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR--AEEEQLQSCKGHETEEFPDE 207
Query: 1579 EELKQRN-------GALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEP 1631
E+L++R G ++Q+ + + + + E + E LR+ +E+ E+ +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 1632 QEPSNKVPEQQRQI 1645
Q + EQ R++
Sbjct: 268 QRELQEEEEQLRKL 281
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 216 bits (549), Expect = 3e-55
Identities = 324/1692 (19%), Positives = 721/1692 (42%), Gaps = 235/1692 (13%)
Query: 9 LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68
L R + +L KS+ + +E ++ Q E D + GR + E ++ E+++ L +Q
Sbjct: 1508 LARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL- 1565
Query: 69 VNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI 128
+ C+SL+L LE L + L KE+E + IA +++ +EL+ E L+
Sbjct: 1566 ---SSSCESLKLALEGLTEDKEKLV---KEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
Query: 129 RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKE 188
++ E +S E E + V+ + ++ +E +L++++ + K EK+L++ ++
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQEL----------YGKLRSTEANKKETEKQLQEAEQ 1669
Query: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNE 248
E++ +++ + K +ILEL+ EE RL +++ + +
Sbjct: 1670 -----------EMEEMKEKMRKFAKSKQQKILELE-------EENDRLRAEVH---PAGD 1708
Query: 249 HLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE 308
++ +E LL+ ASM+E+ + LS ++S + ++ S E+
Sbjct: 1709 TAKECMETLLSS-------NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD--- 1758
Query: 309 ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGA 368
LK E N + Q +L E + D E + E E + L +T+
Sbjct: 1759 -----LKHQIEGNVSKQANL-EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR---- 1808
Query: 369 ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL-------EKLENKRINK 421
+ P+A + V + N Y++ DQL EK +NK ++
Sbjct: 1809 ----PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ 1864
Query: 422 YLDE----IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANK 477
L+ ++ ++ K LK +EE + L+ ++++ + + +L+E ++
Sbjct: 1865 TLENEKNTLLSQISTKDGELKMLQEEVTKMNL----LNQQIQEELSRVTKLKETAEE--- 1917
Query: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
E+D DL +++ L EL + GN+ ++V+ A I + E++ +
Sbjct: 1918 -----EKD---------DLEERLMNQLAELNGSIGNYC---QDVTDAQIKN--ELLESEM 1958
Query: 538 VSYRN-IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKS 596
+ + + EL+++ Q+L+ ++ +E E E K S EL++L K
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK--SHAKELQELLKE 2016
Query: 597 RQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
+Q +++ + Q+D R Q A+ +L+ V S T + ++
Sbjct: 2017 KQQEVKQL-----QKDCIRY---QEKISALERTVKALEFVQTESQKDLEITKENLAQ--- 2065
Query: 657 VPVIESTEAIEAKAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNT 712
+E + +A+A L + + ++ + E A +N K++ E + + ++ ++
Sbjct: 2066 --AVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
Query: 713 KISTQLDFASKRY----EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
+ +L+ A +++ + +Q+ ++ RRE L E ++ T K+++ + + ++L
Sbjct: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
Query: 769 GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT--NLQTIQGIL 826
+LA +L+ +++ + + E + +++ S + + + + L N ++ L
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRV-IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
Query: 827 ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
+ ++ L I +LEH+ + K + EV+ + + L + + QL+
Sbjct: 2241 RQMSIHMEE-LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE----- 2294
Query: 887 HLNTKELLKNAQKEIATLKQHLSNMEVQVASQS-SQRTGKGQPSNKEDVDDLVSQLRQTE 945
T+ L ++Q E+A L+ L +++ Q+ S S K Q N E + +RQ E
Sbjct: 2295 --ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI------IRQQE 2346
Query: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQL 1004
+ + K + ++++ + + + L E +N KE+++ + E AE + Q
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 1005 EKKLMEVE----KEKQE---LQDDKRRAIESMEQQLSELKKTLS-SVQNEVQ-EALQRAS 1055
+K++ E+E +E++E L+++ ++A++ Q + LK ++Q + Q ++ ++
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
++L N++ +I + Q ER L + + +Q A + +K
Sbjct: 2467 SSLQNDRD---------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK---------- 2507
Query: 1116 TTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK 1175
LK+E+ +DL +N L ++ + +
Sbjct: 2508 ----------------------LKEEIRGLRSHMDDLNSENAKLDAELIQYRED------ 2539
Query: 1176 EGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235
LN ++ + Q+Q+LE+ +E E + E ES + + L
Sbjct: 2540 ------LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 1236 QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA 1295
QE + L+ E E ++V+ + + +++ T+ + K+ EE RL Q
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
Query: 1296 KVRKLELDILPLQ-EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEY 1354
++ +LE +++ +Q EA ++ E L+ E K L D ++ + + E
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA--------GIMRNETETAEERV 2705
Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
+L + +++ +T+E L A+I S+++ QN E+L++++ + +
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765
Query: 1415 KDL-------------DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ 1461
K+L DA + + + + T+ + K ++L ++ ++++ S+Q
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMNS-TEENSLSHLEKLN-QQLLSKDEQLLHLSSQ 2823
Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKET---EARNLQEQT 1518
+ + + M L+ + + + E Q++ ++ T E ++L++
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
LQ++ RL ++L++ Q Q+ Q+ITE + + + K ++++L +EN
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITEL-HPLKAQLQEYQDKTKAFQIMQEELRQEN 2942
Query: 1579 EELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKV 1638
+ L +K ++ +K QY IS +++L Q E R +
Sbjct: 2943 LSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002
Query: 1639 PEQQRQITLKTT 1650
+ QRQ + +T+
Sbjct: 3003 VQYQRQASPETS 3014
Score = 206 bits (524), Expect = 2e-52
Identities = 345/1785 (19%), Positives = 762/1785 (42%), Gaps = 215/1785 (12%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
L Q L + EL K+++ L +++ +++ L+ E E +QQ EI ++
Sbjct: 864 LSQALSQKELEI------TKMDQLLLEKKRDVETLQQTIE----EKDQQVTEISFSMT-- 911
Query: 65 QERLVNETRECQSLRLELEKLNNQLKALT--EKNKELEIAQDRNIA-------------- 108
E++V E SL +E++ L QL L+ E+ K+ ++ +D ++
Sbjct: 912 -EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970
Query: 109 ------IQSQFTRTKEELEAEKRDL---IRTNERLSQELEYLTEDVKRLNEKLKE----S 155
+Q +F K+E E KR L + + L Q + L E++ L ++ K+ S
Sbjct: 971 QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030
Query: 156 NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215
T +GE++ + + S+ V + + +E + S+ ++ +E LA +
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 216 GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
+ ++ L++K ++ L+ +++ Q ++ L+T +A + + K
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEIS-------ENQAIIQKLITSNTDASDGDSVALVKE 1143
Query: 276 HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI-------QDHL 328
++ S+ + + E K L + E+L K L+EA + KAI + HL
Sbjct: 1144 TVVISPPCTGSSEHWKP--ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201
Query: 329 LE-VEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK------GAILSEEELAAMSPT 381
E ++Q KD + + E+ KE EN D L + + G + S ++ + S T
Sbjct: 1202 REELKQQKDDYNR-LQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
Query: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
+ +P K TE ++ + L + + L + KA + + +
Sbjct: 1261 PG----LEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 442 EEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI- 500
E+ E K V+S + +L + +E+ +LQE +K + L+ + E+ + L Q++
Sbjct: 1317 EKVELELK-VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 501 ------------RVLLMELEEARGNHVIRDEEVS--SADISSS--------SEVISQ--- 535
R L +L+E + ++E+VS S +S +E+I Q
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 536 ----HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
H +E ++ ++L V L E+ + E +E+ + + ++Q KL++AL +
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ--QIQRKLQAALISRK 1493
Query: 592 QL---RKSRQHQMQL--------------VDSIVRQRDMYR--------ILLSQTTGVAI 626
+ KS Q ++ L V+S V ++ + +L + +
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLIT 1553
Query: 627 PLHASSLDDVSLAS------------TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQ 674
+ S L++ SL+S T + + + + + ESTE E L++
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
Query: 675 LQEIF-ENYKKEKAENEKIQN------EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
EI ++Y+ E E+IQ+ ++ ++L ++ + + QL A + E
Sbjct: 1614 EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 728 LQDNVEGY----RREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN 783
+++ + + +++I L E N +L A + L +N +
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA----------S 1723
Query: 784 LKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ-TIQG-ILERSETETKQRLSSQI 841
+K+E E +K+ LS++ +SL++E+ + + +L+ I+G + +++ E ++ +Q
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783
Query: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEI 901
E + + E E + TR + + + + + + ++ + + N ++I
Sbjct: 1784 NVTEEGTQSIPGETE-EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
Query: 902 ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE---RLKTS 958
LK+ ++ +E + Q+ + + + + + L+SQ+ + ++ L+E ++
Sbjct: 1843 DQLKERIAGLE-----EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897
Query: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES----AEFQTQLEKKLMEVEKE 1014
+++ + VT L+E+ +EK EE N L S + T + K +E E
Sbjct: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Query: 1015 KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
+ L+ E +Q + E K S ++ E E +Q A N+ A+ + QE K
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK-ELQELLKE 2016
Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
+ + +++ + + + AL+ + + + + Q E T++ +Q +E R
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE------HR 2070
Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
++ + S V + + R+L D ++ K + S KE V+ + K ++
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKL--KKELQSNKESVKSQM--------KQKD 2120
Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
+ LE EK + E + ++++LR R++V L E + E+Q +LN + ++VQ +
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALR-REKVHL-EETIGEIQVTLNKKDKEVQQLQE 2178
Query: 1255 TM-AQHEELMKKTETMNVVMETNKMLREEKERLEQD----LQQMQAKVRKLELDILPLQE 1309
+ + +L T++M+ + + + +E ++ E+ +Q + ++R E + L++
Sbjct: 2179 NLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS-QQKDPDT--EEYRKLLSEKEVHTK 1366
++S L+ LE D + W+++ Q V QQK DT E ++LLS+ E
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298
Query: 1367 RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQE 1426
E+ +L++E+ LT+ N ++ KE + + D+ ++
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2358
Query: 1427 KVKTITQVKKIGRRYKTQYEELKAQQDKVM-------ETSAQSSGDHQEQHVSVQEMQEL 1479
+ +++ R +EE+ ++ K++ E + + ++QH +E++EL
Sbjct: 2359 LETDLQASRELTSRL---HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD--KEIKEL 2413
Query: 1480 KETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQE 1539
+ L+Q E ++ LE + + ++ + ++++ +Q +++L + +
Sbjct: 2414 ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 1540 EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRI 1599
+++ + EE+ I+ I A ++L +E L+ L+ + +LD +
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533
Query: 1600 TALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
+ I+ + + ++ E L+Q E + K+ E+ ++
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Score = 203 bits (516), Expect = 2e-51
Identities = 388/1896 (20%), Positives = 755/1896 (39%), Gaps = 351/1896 (18%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRH----EKFKVESEQQYFEIEKRLSHSQERLVNETRE 74
K + K+E +A+++ L+ E+F+ ++ Q E+E R S +++ E E
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQKHKAEMEE 376
Query: 75 CQSLRLELEKLNNQLKALTE--KNKELEIAQDRN-IAIQSQFT--RTKEELEAEKRDLIR 129
S L L+K +L++ + K++ ++ QD+N A+QS T + +++L+ + +++ +
Sbjct: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436
Query: 130 TNERL-----------------SQELEYLTED-VKRLNEKLKESNTTKGELQLKLDELQA 171
RL ++ + +TE+ + L +++ E KG L L EL+
Sbjct: 437 FLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE- 495
Query: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
L+ E E L SQ T L + +T E E+ E+ K
Sbjct: 496 ----------ELKAENEKLSSQITLLEAQNRT---------GEADREVSEISIVDIANKR 536
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKS 291
S E + L+ + K + LL ++KEA+E+ A ++ + + +
Sbjct: 537 SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK-----RAEEADHE 591
Query: 292 AADDSEAKSNELTR-AVEELHKLLKEAGE-----ANKAIQDHLLEVEQSKDQMEKEMLEK 345
D E K E A ++ L++ G+ N+ +E EQ+ + + E+
Sbjct: 592 VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEE 651
Query: 346 IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET 405
I L +A L +TK+ G ++ L+A+ +L L + +E
Sbjct: 652 I-----SLNDAGVELKSTKQDG----DKSLSAVPDIGQCHQD------ELERLKSQILEL 696
Query: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
+L K + + K LDE KE+ +++ ++ + A +LS + +Q + ++
Sbjct: 697 --ELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753
Query: 466 QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
+ L T+ L +++E+ + + +Q R ++ E + + E++ S
Sbjct: 754 KELSMVTE--------LRAQVKQLEMNLAEAERQRR---LDYESQTAHDNLLTEQIHSLS 802
Query: 526 ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET---------TSSKI 576
I + S+ + ++ ++++Q Q +R L + +E E SSK+
Sbjct: 803 IEAKSKDVKIEVLQ-NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 577 TELQLKL---ESALTELEQLRKSRQHQMQLVDSIVRQRD--MYRILLSQT---------- 621
EL L E +T+++QL ++ ++ + + ++D + I S T
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 622 --TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
GV I L+ +S A K+ + + + + + + ++LQ F
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 680 ENYKKEKAE----------NEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
+ KKE + N K +++ +L+E++ +L+ ++ K + E +
Sbjct: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK 1041
Query: 730 DNVEGYRREITS-LHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
+N E + +TS E L T ++E + + +DL EKLA E +K+
Sbjct: 1042 ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL---EEKLAAEEQFQALVKQMN 1098
Query: 789 EML--KLSEVRLSQQRESLLAEQRG--QNLLLTNLQTIQGILERSETET----------- 833
+ L K +++ L Q ++E + Q L+ +N G ET
Sbjct: 1099 QTLQDKTNQIDLLQAE---ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 834 ---KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT 890
K L +I LE E L+KKL+ + R + + + + +L + + +
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 891 KELLKNAQKEIATLKQHLSNMEVQVA-----------SQSSQRTGKG------------- 926
+E KE + L +++QV Q S + G
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 927 ------------QPSNKED---------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQY 965
PS+ ED V + +QL++ E + +L+ ++ ++TS + +
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 966 QAMVTSLEESLNKE-------KQVTEEVRKNIE--VRLKESAEFQTQLEKKLMEVEKEKQ 1016
V L+E +NK+ K V+ E + E + ES++ Q + L E++ +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 1017 ELQ---DDKRRAIESMEQQLSELKKTLSSVQNEV--QEALQRASTALSNEQQARRD---- 1067
ELQ K + + QLSE + L+ +Q E+ QE L +A Q D
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
Query: 1068 ------C---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS-------------- 1104
C Q+ +I E++ K + + L AA + +A KE S
Sbjct: 1456 QLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515
Query: 1105 ---KMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHD 1161
+A V + ++ ++ L EER++++ E+ + + + L L
Sbjct: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI-TEMDRSLLENQSLSSSCESLKL 1574
Query: 1162 QIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVES 1221
+E L++ VKE ++ + ++E + QE+ E +++E EI +E E+
Sbjct: 1575 ALEGLTEDKEKLVKE-IESLKSSKIAESTEWQEKHKE----LQKEYEILLQSYENVSNEA 1629
Query: 1222 LRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKK-TETMNVVMETNKM-- 1278
R + VE + +E QEL L + + T K + + E+ M++ E M ++ +
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689
Query: 1279 --LREEKERLEQDLQQMQAKVRKLELDILPLQEANAE-----------LSEKSGMLQAEK 1325
L EE +RL ++ ++ +L + E LS+K L +EK
Sbjct: 1690 LELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
Query: 1326 KLLEEDVKRWKARNQHLVSQQKDPD-TEEYRKLLSEKEVHTKRIQQLTEE---------- 1374
L E+V+ K + + VS+Q + + TE++ + E T+ I TEE
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809
Query: 1375 --------------------------------IGRLKAEIARSNASLTNNQNLIQSLKED 1402
I +LK IA N+ Q+L+ +
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869
Query: 1403 LNKVRTEKETIQKDLDAKII------------DIQEKVKTITQVKKIGRRYKTQYEELKA 1450
N + ++ T KD + K++ IQE++ +T++K+ K EE
Sbjct: 1870 KNTLLSQIST--KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM 1927
Query: 1451 QQDKVME----------TSAQSSGDHQEQHVS-----VQEMQELKETLNQAETKSKS--- 1492
Q + T AQ + E + V E++E K+ L + +TK +S
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 1493 ---------------LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
+S + LQ+ L EK+ E + LQ+ ++ Q ++S L + ++
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Query: 1538 QEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDV 1597
+ + ++ + +E +A+ K A LA K L E + + K EL
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107
Query: 1598 RITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
++KSQ + + LER L + +E+HL+++ QE
Sbjct: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143
Score = 195 bits (496), Expect = 4e-49
Identities = 339/1650 (20%), Positives = 705/1650 (42%), Gaps = 219/1650 (13%)
Query: 56 EIEKRLSHSQERLVNETREC-----QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
++++RL+++ E+LV E ++ L+ + E L + KA K K+L++ +
Sbjct: 49 DVQERLAYA-EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSL 107
Query: 111 SQFTRTKEELEAEKRDLIRTN----ERLSQELEYLTED---VKRLNEKLKESNTTKGELQ 163
+++ EE++A+ ++ T E+LS+ + TE+ ++++ KL+E LQ
Sbjct: 108 NKYI---EEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164
Query: 164 LKLDELQASDVSVKYRE--------KRLEQEKELLHSQNTWLN-TELKTKTDELLALGRE 214
+L + QA + E ++L++++E + + L+ T+ + +++ RE
Sbjct: 165 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVV---RE 221
Query: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ---QASM 271
K + + ++E+ +L Q + +Q+ + L KL+E +E +A +
Sbjct: 222 KD---ARFETQVRLHEDELLQLVTQAD----VETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 272 EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
+ EL A + + + EA+ N L VE E E+ ++ LEV
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET------EREESKILLEKMELEV 328
Query: 332 EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
+ K + E++ L ++ E A + + + + L ++ A M + + + K
Sbjct: 329 AERKLSFHN-LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 392 GMKLTELYNAYVETQDQLLLEKLEN--------KRINKYLDEIVKEVEAKAPILKRQREE 443
G +L +A + +LL +K E +++ L + KE+ L Q+ E
Sbjct: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
Query: 444 YERAQKAVASLSVKLEQAMKE--IQRLQEDT-DKANKQSSVLERDNRRMEIQVKDLSQQI 500
+Q + + + QA+ E I LQ+ + N++ ++L E++ ++
Sbjct: 448 -TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506
Query: 501 RVLLMELEEARGNHVIRDEEVSSADI----SSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
++ L+E + G E+S DI SSS+E Q ++ Q+++ L V
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE----NTFSQKHKELSVL 562
Query: 557 LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
L E+ E +E +I L+L+L+ E Q +M+ ++ ++
Sbjct: 563 LLEMKEAQE---------EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
Query: 617 LLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
L + TG PL + ++ SL + K ++++ S + E +A LK +
Sbjct: 614 FL-EDTGQDFPLMPN--EESSLPAVEKEQASTEHQSRTS-----EEISLNDAGVELKSTK 665
Query: 677 EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYR 736
+ + + + ++LE+L+ Q+ +L +L+F K E+ + N++
Sbjct: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILEL---------ELNF-HKAQEIYEKNLDEKA 715
Query: 737 REITSLHE-----------RNQKLTATTQKQEQIIN-----TMTQDLRGANEKLAVAEVR 780
+EI++L++ + TA +++++Q+++ +M +LR ++L +
Sbjct: 716 KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE 775
Query: 781 AENLKK-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT----IQGILERSETETKQ 835
AE ++ + E + L++Q SL E + +++ + LQ +Q L+ SE T
Sbjct: 776 AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ--LQFSEQSTLI 833
Query: 836 R-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
R L SQ++ E E+ LE RH ++ ++ ++++L+ +LL
Sbjct: 834 RSLQSQLQNKESEV------LEGAERVRHISSKVEELSQALSQKELEIT-----KMDQLL 882
Query: 895 KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
++++ TL+Q + + QV S T K N+E L +++ +EQ+N L
Sbjct: 883 LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS-LGVEIKTLKEQLNLLSRA 941
Query: 955 LKTSTSNVEQYQAMVTSLEESLNKEKQV----TEEVRKNIEVRLKESAEFQTQLEKKLME 1010
+ VE+ + + L+++ ++ EE++ ++ KE+ + + +L+ L+
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
++EL R E + E KK + + E E + +E+ CQE
Sbjct: 1002 ----RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
+ ++ E EL D+E AA+EQ + + + +T Q +Q+ +A
Sbjct: 1058 IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALV---KQMNQTLQDKTNQIDLLQAE 1114
Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ-GPLNVSLSEE 1189
E + +++ +L+ + VA VKE V P SE
Sbjct: 1115 ISENQAIIQ-----------------KLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
Query: 1190 GKS--QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
K +E+IL + EKE E L+++LQE S A +
Sbjct: 1158 WKPELEEKILAL------EKE-------------------KEQLQKKLQEALTSRKAILK 1192
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
K Q K EEL ++ + N + E +E E + L+Q+Q +VR+ LP
Sbjct: 1193 KAQ--EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK- 1366
+ S G+ + K E+ Q ++ PD + + S + T
Sbjct: 1251 TDQQESCSSTPGLEEPLFKATEQH------HTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
Query: 1367 -----RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE---TIQKDLD 1418
+++++ E L+ +++ + + LT + L+E +NK E E T+ + +
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
Query: 1419 AKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478
+Q+K+++ +Q++ G E L+ Q K+ E S ++ ++ E
Sbjct: 1365 VHAESLQQKLES-SQLQIAG------LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
Query: 1479 LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQ 1538
+ L + +T+ E ++ L L E +A+ E+ QLQ EL ++Q + +
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQL---EMQAKEHDERIKQLQVELCEMKQK-PEEIGE 1473
Query: 1539 EEQLRQQITEK-------EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ 1591
E + +QQI K ++ K + + +++ G ++LTK +++ + A +++
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
Query: 1592 KDELDVRITALKSQYEGRISRLERELREHQ 1621
KD + R+ L+ + + I+ ++R L E+Q
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQ 1563
Score = 152 bits (384), Expect = 4e-36
Identities = 275/1346 (20%), Positives = 538/1346 (39%), Gaps = 196/1346 (14%)
Query: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE--QQYFE------- 56
Q V + N+L +S L+K +++ + E L EK KVESE ++Y E
Sbjct: 1942 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV--KEKTKVESEIRKEYLEKIQGAQK 1999
Query: 57 ----------IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKAL----TEKNKELEIA 102
+++ L Q+ + ++C + ++ L +KAL TE K+LEI
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
Query: 103 QDRNIA----------------------IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
++ N+A QS+ R + K++L E + +++
Sbjct: 2060 KE-NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Query: 141 LTEDVKRLNEKLKESNTT-KGELQLKLDELQAS-----------DVSVKYREKRLEQEKE 188
ED++R E+ +E + K +Q KLD L+ V++ ++K ++Q +E
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178
Query: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKC-------NLENKKEEVSRLEEQMN 241
L S T +L T + +L ++ I E K +++K+EE+ E+ +
Sbjct: 2179 NLDSTVT----QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
LK + H+E+L + + + E K E+ L + D + ++
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ-------LQQKVCDTLQGENK 2287
Query: 302 ELTRAVEELHKL-------LKEAGEANKAIQDHLLEVEQS--KDQMEKEMLEKIGRLEKE 352
EL +EE L L + K+++D L ++ S K + +K LE I R ++E
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR-QQE 2346
Query: 353 LENANDLLSATKRKGAILSEEELAA-----MSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
+ N S + + + + EL + ++ + ++ + ++ A + Q
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 408 QLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR--EEYERAQKAVASLSVKLEQAMKEI 465
+++LEN + + IV E E K + K + E + +K +L+ +K +
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 466 QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
LQ D D+ LE + + ++ L Q+ +L+E IR D
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE-----IRGLRSHMDD 2521
Query: 526 ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLES 585
++S + + L+ YR E+L Q ++L E + ++ +E +K +L+ KL+
Sbjct: 2522 LNSENAKLDAELIQYR--EDLNQVITIKDSQQKQLLEVQLQQNKEL-ENKYAKLEEKLKE 2578
Query: 586 ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
+ E LR+S + + ++ + ++ +SQ T L + A +
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
Query: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
+S + S++ K++ E+ E + E K E +KL++++
Sbjct: 2639 EEVHRLSA-----LFSSSQ--------KRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685
Query: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
L + + + A +R L ++ +++ + + N+ LTA Q + ++++
Sbjct: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
Query: 766 DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
ANE+L + + + KE LK + L+++R++LL+E
Sbjct: 2746 SRDHANEELDELKRKYDASLKELAQLK-EQGLLNRERDALLSETAF-------------- 2790
Query: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
S T++ S +EKL ++ L K D QLL QL+ N
Sbjct: 2791 ---SMNSTEENSLSHLEKLNQQL--LSK----------------DEQLLHLSSQLEDSYN 2829
Query: 886 LHLNTKELLKNAQKEIATLKQHLSN-MEVQVASQSSQRTGKGQPSNKE-DVDDLVSQLRQ 943
+ + + + Q E + HL N +E S+ ++ QPS +V L +
Sbjct: 2830 QVQSFSKAMASLQNE----RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885
Query: 944 TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
+ + L + LK Q +T L L + Q ++ K ++ +E +
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHP-LKAQLQEYQDKTKAFQIMQEELRQENLS 2944
Query: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
+ +L ++ EK + +RR E +S+ + LS +QN ++E +S + Q
Sbjct: 2945 WQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
Query: 1064 ARRDCQEQAKIAVEAQNK--YERELMLHAAD--VEALQAAKEQVSKMASVRQHLEETTQK 1119
+R + + + YE EL+ + ++ + + ++ ++ S L E
Sbjct: 3005 YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNT 3064
Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
QL + S E ++ D ++ C LEKQ V+E
Sbjct: 3065 LSIQLCDTSQSLRENQQHYGDLLNHCAV----LEKQ------------------VQELQA 3102
Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETR-----FEVAQVESLRYRQRVELLERE 1234
GPLN+ ++ G QE+ + R+ + E R F AQ + RQ V L +
Sbjct: 3103 GPLNIDVA-PGAPQEK-----NGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
Query: 1235 LQELQDSLNAEREKVQVTAKTMAQHE 1260
L+E +D A + V + + + E
Sbjct: 3157 LEEERDQRVAAENALSVAEEQIRRLE 3182
Score = 130 bits (328), Expect = 1e-29
Identities = 206/993 (20%), Positives = 425/993 (42%), Gaps = 152/993 (15%)
Query: 754 QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ- 812
Q+ + N TQ+ E+LA AE LK ++++ +V+L Q+ E+L E++
Sbjct: 36 QESDMEFNNTTQE--DVQERLAYAEQLVVELK---DIIRQKDVQLQQKDEALQEERKAAD 90
Query: 813 -----------------NLLLTNLQTIQGILERSETETKQRLSSQIEKL---EHEISHLK 852
N + ++ G + +E +++++LS + E EI +K
Sbjct: 91 NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150
Query: 853 KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNME 912
KL+ + E TL L + Q TE + K+ L+ ++ I+TL+ LS +
Sbjct: 151 HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210
Query: 913 VQVASQS--SQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT 970
+ A+Q ++ + + + D+L+ + Q + + +++++L+ +E++
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET-EMQQKLRVLQRKLEEH----- 264
Query: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ-LEKKLMEVEKEKQELQ-------DDK 1022
EESL QV + +++ + +AE + Q L ++L ++E E L+ ++
Sbjct: 265 --EESLVGRAQVVDLLQQELT-----AAEQRNQILSQQLQQMEAEHNTLRNTVETEREES 317
Query: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA--LSNEQQARRDCQEQAKIAVEAQN 1080
+ +E ME +++E K + ++Q E+ L++ A E ++R EQ K E +
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ-KHKAEMEE 376
Query: 1081 KYERELMLHAADVE---ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
K L L E A A K+Q SK+ + E+ Q A++ E++ +
Sbjct: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDKN--EQAVQSAQTI-----QQLEDQLQQ 429
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV-KEGVQGPLNVSLSEEGK----- 1191
E+S+ + NRL Q E S V EG Q +++ K
Sbjct: 430 KSKEISQFL---------NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ--DSLNAEREKV 1249
E+ +L I E+ AE +Q+ L + R +RE+ E+ D N
Sbjct: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
+ + + + ++ K E +++E ++E +E + Q+Q K R E D L +
Sbjct: 541 EESGQDVLENTFSQKHKELSVLLLE----MKEAQEEIAFLKLQLQGK-RAEEADHEVLDQ 595
Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
+ E G+ + K+ ED ++ L+ P+ E + +++ T+
Sbjct: 596 KEMKQMEGEGIAPIKMKVFLEDT----GQDFPLM-----PNEESSLPAVEKEQASTEHQS 646
Query: 1370 QLTEEIG------RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTE-----------KET 1412
+ +EEI LK+ + SL+ ++ Q +++L +++++ +E
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM---------------- 1456
+K+LD K +I + I + KK + + L ++D+++
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV 766
Query: 1457 --------ETSAQSSGDHQEQ----HVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
E Q D++ Q ++ +++ L + K + L+++++++Q
Sbjct: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
Query: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE---EKTRKAIVAAK 1561
SE+ T R+LQ Q +SE+ + ++ +++ E+L Q +++KE K + ++ K
Sbjct: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886
Query: 1562 SKIAHLAGV---KD-QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLEREL 1617
+ L KD Q+T+ + + ++ L+++K L V I LK Q +SR E
Sbjct: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAK 945
Query: 1618 REHQERH------LEQRDEPQEPSNKVPEQQRQ 1644
+E E L+Q + P+ ++ +++ Q
Sbjct: 946 KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Score = 75.1 bits (183), Expect = 8e-13
Identities = 94/458 (20%), Positives = 214/458 (46%), Gaps = 48/458 (10%)
Query: 1231 LERELQELQDSL--NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
L+ EL + D N +E VQ + +A E+L+ E +++ + + L+++ E L++
Sbjct: 30 LDPELHQESDMEFNNTTQEDVQ---ERLAYAEQLV--VELKDIIRQKDVQLQQKDEALQE 84
Query: 1289 DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKD 1348
+ + K++KL+L A A+L+ + ++ E K V + +++ +S+
Sbjct: 85 ERKAADNKIKKLKL------HAKAKLTSLNKYIE-EMKAQGGTVLPTEPQSEEQLSKHDK 137
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA-----SLTNNQNLIQSLKEDL 1403
TEE ++ EK H ++Q+ E I L+A++ ++ A S T + + +K+ L
Sbjct: 138 SSTEEEMEI--EKIKH--KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM-MKQQL 192
Query: 1404 NKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSS 1463
EKE L A++ Q + V++ R++TQ ++ +D++++ Q+
Sbjct: 193 Q----EKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQ---VRLHEDELLQLVTQAD 245
Query: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
+ + Q Q+++ L+ L + E V+ LQ+ L+ E + L +Q Q+++
Sbjct: 246 VETEMQ----QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA 301
Query: 1524 ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
E + LR ++ + + L +++ + + + + + ++ HL +Q + EL+
Sbjct: 302 EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
Query: 1584 RNGALDQQ-KDELDVRIT----------ALKSQYEGRISRLERELREHQERHLEQRDEPQ 1632
R AL+Q+ K E++ + + L+S + + + L++ E+ ++ Q
Sbjct: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ 421
Query: 1633 EPSNKVPEQQRQIT--LKTTPASGERGIASTSDPPTAN 1668
+ +++ ++ ++I+ L P + TS P N
Sbjct: 422 QLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN 459
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 207 bits (527), Expect = 1e-52
Identities = 351/1642 (21%), Positives = 663/1642 (40%), Gaps = 189/1642 (11%)
Query: 145 VKRLNEKLKESNTTKGELQLKLDE----LQASDVSVKYREKRLEQ-----EKELLHSQNT 195
++RL ++L + + + EL+L+L E L D + ++R+++ EK+
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 196 WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE 255
EL+ K + L E + +LK ++++L E+ L H++
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 256 DLLTKLKEAKEQQASMEEKF-------HNELNAHI---------------KLSNLYKSAA 293
L L E E+ + +++ EL+A + KLS L + +
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 294 ---DDSEAKSNELTRAVEELHKLLKEAGEA---NKAIQDHLLEVEQSKDQMEKEMLEKIG 347
D+ + E+ V +L L +EA N +Q + +E + Q E ++L + G
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 348 RLEKELENAN----DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYV 403
E+E + + DL S+ E E A+ + A A++ +LT L NA +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL-NATI 514
Query: 404 ETQDQLLLE-KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
+ QDQ L K + K L + +++ E + L+ Q E+ + K + EQ +
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK-------QKEQQL 567
Query: 463 KEIQRLQEDTDK----------ANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELE-- 508
KE+ QE T + +++S+ ERD +++E K+ + ++ +L +L+
Sbjct: 568 KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
Query: 509 -EAR--GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRE 565
EAR + + A++S E + Q V E+ + Q Q + L+ E ++
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 566 REEQETTSSKITELQLKLESALTELEQLRKS-RQHQMQLVDSIVRQRDMYRILLSQTTGV 624
E+E + + +LQ +L++ L+ + S + + + D++ Q+ L ++T +
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL 746
Query: 625 AIPLH---ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFEN 681
+ H L++ Q + E EA AA + E
Sbjct: 747 -VEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805
Query: 682 YKKEKAE-NEKIQNEQLEK------LQEQVTDLRSQNTKISTQLDFASKRYEMLQDN--- 731
KE A E+ ++ Q E+ QEQ+ L+ + K +L A ++ ++ +
Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865
Query: 732 -VEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE---VRAENLKKE 787
+ + E+ LH + Q++E + DL EK+A R E L ++
Sbjct: 866 QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK 925
Query: 788 ---------KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLS 838
+E++K R ++ L EQ+G+ T Q L+ E E +Q +
Sbjct: 926 AGEQQETASRELVK-EPARAGDRQPEWLEEQQGRQFCST-----QAALQAMEREAEQ-MG 978
Query: 839 SQIEKLEHEISHLKKKLENEVEQRH----TLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
+++E+L + + + + E Q+ LT+ D + L + + L
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 895 KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
+ E ATL++ L++ + + Q K + + +L +LRQT V LKE+
Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKEL-EELRQT---VKQLKEQ 1093
Query: 955 LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE 1014
L +++ + + E+ + TE +E E ++ + Q +K
Sbjct: 1094 L---AKKEKEHASGSGAQSEAAGR----TEPTGPKLEALRAEVSKLEQQCQK-------- 1138
Query: 1015 KQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
+QE D R++E+ +E L ++Q +++E Q + S A+R+ +
Sbjct: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-AAFRT 1197
Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
V+ +K E E A +++ + S+ LEE Q+LE + +E
Sbjct: 1198 KVQDHSKAEDEWKAQVA------RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
+R++ E K + LE++ RLL Q E S+ A+ + SL EE + Q
Sbjct: 1252 KRLVMAESEK----SQKLEERLRLL--QAETASNSARAAERSSALREEVQSLREEAEKQR 1305
Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
E L R+E R E E ++++ E+ L LQ E Q
Sbjct: 1306 VASENL---RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ----LEHTSTQALVS 1358
Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL---DILPLQEAN 1311
+ + L ++ + E K REE E+ +Q ++A++ + + +++PL++
Sbjct: 1359 ELLPAKHLCQQLQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKV 1416
Query: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
AE + L+AEK E + K + L + + R L + + + Q
Sbjct: 1417 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE---RANLGRQFLEVELDQAR 1473
Query: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN-----------KVRTEKETIQKD---L 1417
+ + L A A + L Q QS +L KV E++ Q++ L
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL 1533
Query: 1418 DAKI--IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE 1475
A++ +++ ++ +T QV+++ ++ + K QQ K+ AQ QE +
Sbjct: 1534 TAQVEQLEVFQREQT-KQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ 1592
Query: 1476 MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQ---TVQLQSELSRLRQDL 1532
+ EL+ L+Q E ++ + Q+E + K+ + + LQEQ QLQ E LR +
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652
Query: 1533 QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK------ENEELKQRNG 1586
+ + +Q + E E+ R +S A +A QL + LK R
Sbjct: 1653 ERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE- 1711
Query: 1587 ALDQQKDELDVRITALK-SQYEGRISRLERELREHQERHLEQRDEPQEP-SNKVP---EQ 1641
Q K +LD+ I +L S EG + +L Q EP P S ++P E
Sbjct: 1712 --PQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVES 1769
Query: 1642 QRQITLKTTPASGERGIASTSD 1663
+ PA + + S+ D
Sbjct: 1770 LESLYFTPIPARSQAPLESSLD 1791
Score = 195 bits (496), Expect = 4e-49
Identities = 316/1567 (20%), Positives = 643/1567 (41%), Gaps = 182/1567 (11%)
Query: 29 LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE---RLVNETRECQSLRLELEKL 85
+A Q ID L +EK + S + E+E+ ++ RL ++CQ L+ E ++
Sbjct: 251 IAMMQQRIDRLALLNEK-QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQM 309
Query: 86 NNQLKALTEKNKELEIAQDRNIA-----IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
+ ++ L+E+N +L + R A +Q EE ++ + +L +EL
Sbjct: 310 DRKINQLSEENGDLSF-KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368
Query: 141 LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK-------YREKRLEQEKELLHSQ 193
+D K L EK + +L+ L +LQ + K + + L+QE L +
Sbjct: 369 ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
Query: 194 NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
NT L ++ L E+G + +L + +EE +L + L++S
Sbjct: 429 NTQLQARVE-------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS------- 474
Query: 254 VEDLLTKLKEAKEQQASMEEKFHNELNAHI-----KLSNLYKSAADDSEAKSNELTRAVE 308
++ L +AKE+ + L A + +L+ L + + + +A E
Sbjct: 475 ----ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530
Query: 309 ---ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE-KELENANDLLSATK 364
+L + L++ +A++ ++ + ++ S Q E+++ E + E ++A L +A +
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590
Query: 365 RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLD 424
+ A L E + A A K K + +L A E +D + +R L
Sbjct: 591 EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN-EARDSAQTSVTQAQREKAELS 649
Query: 425 EIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLER 484
V+E++A ++ R+E AQ VA L E+Q E K+ E+
Sbjct: 650 RKVEELQA---CVETARQEQHEAQAQVAEL---------ELQLRSEQQKATEKERVAQEK 697
Query: 485 DNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSS-EVISQHLVSYRNI 543
D + ++Q S ++ +E E+ R + +++ +++ + + ++ QH + +
Sbjct: 698 DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL 757
Query: 544 EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQL 603
EE + + L L++LGE + E E ++ E +A +E EQL K +
Sbjct: 758 EEERAGRKGLEARLQQLGEAHQ-AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
Query: 604 VDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIEST 663
+ ++ Y + + + + + V IES
Sbjct: 817 YEDSQQEEAQYGAMFQ--------------EQLMTLKEECEKARQELQEAKEKVAGIESH 862
Query: 664 EAIEAKAALKQLQEIFENYKK------EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
++ +L E+ N + EK + + L LQE++ + ++ T
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 718 LDFASKRY-----EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
+ A ++ E++++ R+ L E+ + +TQ Q + + + E
Sbjct: 923 VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELE 982
Query: 773 KLAVAEVRAENLKKEKEMLKLSEVRLSQQRE-SLLAEQRGQNLLLTNLQTIQGILERSET 831
+L A + ++ ++E+ R Q+RE + L ++RG+ Q + + +
Sbjct: 983 RLRAALMESQGQQQEE--------RGQQEREVARLTQERGR------AQADLALEKAARA 1028
Query: 832 ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTK 891
E + RL + + + E + L++ L + + ++ + L Q+ L K
Sbjct: 1029 ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK 1088
Query: 892 ELLKN-AQKEIATLKQHLSNMEVQ-VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
+L + A+KE K+H S Q A+ ++ TG + + +V L Q ++ +EQ +
Sbjct: 1089 QLKEQLAKKE----KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Query: 950 DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
L+ L+ ++ + + + +L+ L ++ Q + + +E A F+T+++
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204
Query: 1010 EVEKEKQELQDDKRRA------IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
++ K ++ ++ A I S+E+++S L + + + E +E L+R A S + Q
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE-LKRLVMAESEKSQ 1263
Query: 1064 ARRDCQE--QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAE 1121
+ QA+ A + ER L + A++Q ++RQ L ++AE
Sbjct: 1264 KLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
Query: 1122 SQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGP 1181
E KA W+E+ +K+ L Q+E S + + S +
Sbjct: 1324 ELGQELKA-WQEK----------------FFQKEQALSTLQLEHTSTQALVSELLPAK-- 1364
Query: 1182 LNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL--ERELQEL- 1238
L ++ ++++ E +R +E E+ Q + R ELL +REL EL
Sbjct: 1365 ---HLCQQLQAEQAAAE-----KRHRE------ELEQSKQAAGGLRAELLRAQRELGELI 1410
Query: 1239 ---QDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA 1295
Q ER Q+ A+ + E+L + ++ E N+ L E Q L+
Sbjct: 1411 PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470
Query: 1296 KVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-VSQQKDPDTEEY 1354
+ R+ + L A+AE +A+ E +V K + V +++ EE
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
+KL ++ E ++ T+++ L ++A S+ + Q +++++ + + E + +Q
Sbjct: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQ 1590
Query: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
L+ E ++Q ++ YK Q E+ K D + + Q
Sbjct: 1591 AQLN-------ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN--------------Q 1629
Query: 1475 EMQELKETLNQAETKSKSLESQVENL-----QKTLSEKETE--ARNLQEQTVQLQSELSR 1527
E+QE +L Q + ++K L ++ E L Q L KE E R+L Q L+++++
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH 1689
Query: 1528 LRQDLQD 1534
Q L+D
Sbjct: 1690 ADQQLRD 1696
Score = 176 bits (447), Expect = 2e-43
Identities = 331/1601 (20%), Positives = 662/1601 (41%), Gaps = 226/1601 (14%)
Query: 52 QQYFEIEKRLSHSQERLVNETRECQS-LRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
QQ + L+ + E E Q+ L EL K L EKN EI Q + ++
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKN---EILQGKLSQLE 391
Query: 111 SQFTRTKEELEAEKRDL---IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL- 166
++ ++ EK ++ + E L QE L + +L +++ T +G+ + KL
Sbjct: 392 EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLL 451
Query: 167 -----------------DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELL 209
+LQ+S ++ ++ LEQ + + L ++ + T EL
Sbjct: 452 AERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ---AHGARLTAQVASLTSELT 508
Query: 210 ALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
L + EL + KE+ ++L + + + +++ L+ VE L + LK+ ++Q
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
Query: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLL 329
+ EK H + +AA++ EA E A+++L L KE + +Q L
Sbjct: 569 EVAEKQEATRQDH---AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQ 625
Query: 330 EVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSE--EELAAMSPTAAAVAK 387
+++D +A ++ +R+ A LS EEL A TA
Sbjct: 626 VANEARD------------------SAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667
Query: 388 IVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERA 447
+ + EL + ++ Q EK +R+ + D++ ++++A LK + E
Sbjct: 668 EAQAQVAELEL---QLRSEQQKATEK---ERVAQEKDQLQEQLQALKESLKVTKGSLEEE 721
Query: 448 QKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQ-IRVLLME 506
++ A + ++ + E+ KA +S V + R E++ + ++ + L +
Sbjct: 722 KRRAADALEEQQRCISEL--------KAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Query: 507 LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
L EA A+ +++ + + E +Q + + A RE E ++
Sbjct: 774 LGEAH-----------QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 567 EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAI 626
EE + + + E +T E+ K+RQ + + + + +S+
Sbjct: 823 EEAQYGA-------MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELA 875
Query: 627 PLHAS---SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYK 683
LHA+ +L V + + +ST S E + +++ E E
Sbjct: 876 ELHANLARALQQVQ-EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
Query: 684 KEKA-ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSL 742
+E E + + Q E L+EQ Q L + E + + +E R +L
Sbjct: 935 RELVKEPARAGDRQPEWLEEQ---QGRQFCSTQAALQAMEREAEQMGNELERLR---AAL 988
Query: 743 HERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQ 801
E + +QE+ + +TQ+ A LA+ + RAE + + L V +
Sbjct: 989 MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
Query: 802 RESL---LAEQRGQNLLLTNL---------------QTIQGILERSETETKQRLSS---- 839
+E+L L E+ G++ L L QT++ + E+ + K+ S
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
Query: 840 ------------QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQ----------LLDTK 877
++E L E+S L+++ + + EQ +L R+L+ + L +
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168
Query: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSN-------MEVQVA--SQSSQRTGKGQP 928
QL+ + +++ L +AQ+E+A + + + + QVA Q ++R
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE-ESLNKEKQVTEE-- 985
S +E+V L Q+ + E + +LK + + ++ + + L+ E+ + + E
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Query: 986 -VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQ 1044
+R+ ++ L+E AE Q + L + + E ++ + +++ +++ + ++ LS++Q
Sbjct: 1289 ALREEVQ-SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347
Query: 1045 NEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAAD---VEALQAAKE 1101
E S L + ++ EQA A E +++ E E AA E L+A +E
Sbjct: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQA--AAEKRHREELEQSKQAAGGLRAELLRAQRE 1405
Query: 1102 QVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD------EVSKCVCRCEDLEKQ 1155
+ ++ +RQ + E + A+ QL KAS+ E+ MLK E ++ + +L +Q
Sbjct: 1406 -LGELIPLRQKVAEQERTAQ-QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQ 1463
Query: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFE 1215
L ++++ +K V + V+ L+E + + RE E+ ++E
Sbjct: 1464 --FLEVELDQAREKYVQEL-AAVRADAETRLAEVQREAQS-------TARELEVMTAKYE 1513
Query: 1216 VAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA-QHEELMKK----TETMN 1270
A+V+ L RQR QE + L A+ E+++V + Q EEL KK +
Sbjct: 1514 GAKVKVLEERQR-------FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
V + K ++ + +Q+ Q++QA++ +L+ Q + E + + LQ EK
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQ-----AQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 1331 DVKRWKARNQHLVSQQKDPD--TEEYRKLLSEKE----------VHTKRIQQ----LTEE 1374
D K K +NQ L Q + + +E ++L +E E + TK +Q LT +
Sbjct: 1622 DAK--KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679
Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ-EKVKTITQ 1433
+ L+A++A ++ L + + D K R + Q DL +D+ E+ ++
Sbjct: 1680 VRSLEAQVAHADQQLRDLGKF--QVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSI 1737
Query: 1434 VKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
K+ R Q D +S Q V+ ++ L T A +++ L
Sbjct: 1738 TSKLPR----------TQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQA-PL 1786
Query: 1494 ESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
ES +++L + + R+ + +T Q+ + + D+++
Sbjct: 1787 ESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEE 1827
Score = 145 bits (365), Expect = 6e-34
Identities = 241/1288 (18%), Positives = 538/1288 (41%), Gaps = 165/1288 (12%)
Query: 2 AAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKV---ESEQQYFEIE 58
A + QQ E L + K Q +L + L Q+ GL+ + E+ + EQQ E+
Sbjct: 512 ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
Query: 59 K-----RLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN--------KELEIAQDR 105
+ R H+Q+ L E ++ E + QL+AL ++ ++L++A +
Sbjct: 572 EKQEATRQDHAQQ-LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 106 NIAIQSQFTRTK----------EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155
+ Q+ T+ + EEL+A + ++ L ++ +K E
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 156 NTTKGELQLKLDELQASDVSVKYREKRLEQEK----ELLHSQNTWLNTELKTKTDELLAL 211
E ++LQA S+K + LE+EK + L Q + +ELK +T L+
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-SELKAETRSLVEQ 749
Query: 212 GREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLL-------TKLKEA 264
+ + E+ E + +K +RL++ + E L++ + + + ++ ++
Sbjct: 750 HKRERKELEEERA---GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL 806
Query: 265 KEQQASMEEKFHNELNAHIKLSNLYK----SAADDSEAKSNELTRAVE-----ELHKLLK 315
++ A+ E++ + + +++ + ++ E EL A E E H L+
Sbjct: 807 VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866
Query: 316 EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375
+ + N+ + H + EKE+ + +L +L + ++AT ++ A L
Sbjct: 867 ISRQQNELAELHANLARALQQVQEKEV--RAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 376 AAMSPTAAAVAKIVKPGMKLTELYNAYVETQD--QLLLEKLENKRINKYLDEIVKEVE-A 432
A A ++VK + + ++E Q Q + + + + +++ E+E
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 433 KAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQ 492
+A +++ Q ++ E + Q +E+ RL ++ +A ++ + +E++
Sbjct: 985 RAALMESQGQQQE-----------ERGQQEREVARLTQERGRAQADLALEKAARAELEMR 1033
Query: 493 VKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR 552
+++ + RV L+EA H + ++E ++ +++ + +EEL+Q ++
Sbjct: 1034 LQNALNEQRVEFATLQEALA-HALTEKEGKDQEL---AKLRGLEAAQIKELEELRQTVKQ 1089
Query: 553 L--LVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610
L +A +E Q + + KLE+ E+ +L + Q Q + DS+ R
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
Query: 611 RDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKA 670
+ R AS +R S +T+ ++ E +++
Sbjct: 1150 LEAER-----------------------ASRAERDSALETLQGQLEE---KAQELGHSQS 1183
Query: 671 ALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIST---QLDFASKRYEM 727
AL Q ++ + ++ K ++E ++ + +N+ IS+ ++ +++
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Query: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
+ + +R + + E++QKL + + T + R A A+ E ++L++E
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQ--AETASNSARAAERSSALRE-EVQSLREE 1300
Query: 788 KEMLKLSEVRLSQQRESLL--AEQRGQNLLLTNLQTIQ-----GILERSETETKQRLSSQ 840
E +++ L Q+ S AE+ GQ L + Q L+ T T+ +S
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
Query: 841 I------EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
+ ++L+ E + +K+ E+EQ L +LL +R+L L E
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420
Query: 895 KNAQK---EIATLKQHLSNMEVQVASQSSQRTGKGQPSN--------------KEDVDDL 937
+ AQ+ E A+ + LS ++ + + G G+ +N ++ V +L
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+ E ++ +++ +++ +E A + + +E+Q +E R+ + ++++
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540
Query: 998 AEFQTQLEKKLMEVEK------EKQELQDDKRRAIES-----------MEQQLSELKKTL 1040
FQ + K++ E+ K + ++Q K +A+++ ++ QL+EL+ L
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 1041 SSVQNEVQE---ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQ 1097
S + + +++A T ++Q ++ QEQ + ++E K +EL A+ E L
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR-SLEQLQKENKEL---RAEAERLG 1656
Query: 1098 AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNR 1157
+Q + E+T + +Q+ +A ++ L+D + K + L+ +
Sbjct: 1657 HELQQAGLKT---KEAEQTCRHLTAQVRSLEAQVAHADQQLRD-LGKFQVATDALKSREP 1712
Query: 1158 LLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
Q++ D + S +EG PL+++
Sbjct: 1713 QAKPQLDLSIDSLDLSCEEGT--PLSIT 1738
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 206 bits (525), Expect = 2e-52
Identities = 288/1409 (20%), Positives = 601/1409 (42%), Gaps = 173/1409 (12%)
Query: 296 SEAKSNELTRAVEELHKLLKEAG---EANKAIQ-DHLLEVEQSKDQMEKEMLEK---IGR 348
S ++EL + E +H ++G E+N A++ D + + Q ++ + E+
Sbjct: 49 SLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEE 108
Query: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
L+KELE L + ++++ A + + + + ++ + + + Q
Sbjct: 109 LKKELEKYQGLQQQEAKPDGLVTDSS-AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 167
Query: 409 LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468
L E + K +KY +E R E A++ V L+ +L + IQ L
Sbjct: 168 LATEIADIK--SKYDEE---------------RSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLL--MELEEARGNHVIRDEEVSSADI 526
+ + +L+R +K Q++ L+ M LE R + ++DE
Sbjct: 211 KTE---------LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 527 SSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK-ITELQLKLES 585
+SSE L S EL + Q + V ++EL + + + T ++ +TE LK E
Sbjct: 262 YASSEATISQLRS-----ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 586 ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
T+LE+ + + + + Q+D L Q + +SL + + + K
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKD----LDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
+T + + V T+ KA KQLQ+ E ++ + + N+ KL E
Sbjct: 373 ATQKLKEELSEV----ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER-NQKLTATTQKQEQIINTMT 764
L + ++ Q +S++ + V + +++ L E+ +K+T +T+ Q Q+ T
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 765 QDL------RGANEKLAVAEVRAENLKKE----KEMLKLSEVRLSQQRESLLAEQRGQNL 814
Q + KL A+ E + ++ + ++ E L + +E++ ++ +
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
L +Q +G ET +L + L+ +++ L +KL+N+ E NL Q+
Sbjct: 549 LYAKIQAGEG-----ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 875 DTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDV 934
+ K L + L+ + + ++ K+ +S +++Q+ +++ + +
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS-AEAAKTAQR 662
Query: 935 DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL 994
DL + L + + D ++ L T+ ++Q A + +E ++ +E L
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-----------LESHL 711
Query: 995 KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
KE E LE+K E+E + ++L+ D S EQ L +L++ Q ++ L+
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-----QRQLNTDLELR 766
Query: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
+T LS + + ++ ++ ++ ++ EAL++ K++++K +Q L+
Sbjct: 767 ATELSKQLEMEKEIVSSTRLDLQKKS-------------EALESIKQKLTKQEEEKQILK 813
Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
Q E+ E K EE L + + V + ++ + L ++ + DK+ + V
Sbjct: 814 ---QDFETLSQETKIQHEE----LNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKV 865
Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
+ ++ + E K + IL++ EK E + ++ + ++E +E
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDL------EKTCKELKHQL--------QVQMENTLKE 911
Query: 1235 LQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
+EL+ SL E+E Q+ + + E+L++ T+ + + L+ L+Q +Q
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 1294 QAKVRKL--ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT 1351
+ ++ L EL I LQ+ E + + QA ++L E K +N + SQ
Sbjct: 972 KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ------ 1025
Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
E +++L S+ + +++ ++ +++ + L +N+N I + + + +++T K
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 1412 TIQKDLDAKIIDIQEKVKTITQVKK---------IGRRYK-TQYEELKAQQDKVMETSAQ 1461
T+++D K +QE+ K + ++K + + K + EE+K +Q+K + +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 1462 SSGDHQEQHVS-VQEMQELKETLNQAET----KSKSLESQVENLQKTLS--------EKE 1508
H+ + + + +++ K+ L Q + K+ SL++ VE ++ E+E
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568
+ E+ +L SE+ ++ E +L QIT E +L
Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE--------------NLG 1251
Query: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQR 1628
VK KE + ++R L++Q D+L I L E + + E R ER L+
Sbjct: 1252 TVK----KEWQSSQRRVSELEKQTDDLRGEIAVL----EATVQNNQDERRALLERCLKGE 1303
Query: 1629 DEPQEPSNKVPEQQRQITLKTTPASGERG 1657
E ++ KV E QR++ TT A E G
Sbjct: 1304 GEIEKLQTKVLELQRKLD-NTTAAVQELG 1331
Score = 201 bits (512), Expect = 5e-51
Identities = 286/1324 (21%), Positives = 577/1324 (43%), Gaps = 160/1324 (12%)
Query: 199 TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSN----EHLQKHV 254
T L+ + +L A +E+ ELK LE K + + + E + +GL T + + L++ +
Sbjct: 86 TLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 255 EDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL 314
E+ T+ K+ + E+K + + Y EA ++TR EEL+K
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK-- 202
Query: 315 KEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS----ATKRKGAIL 370
EA IQD E+ +++ +E + L+KEL L+ +R+ L
Sbjct: 203 ----EAT-VIQDLKTEL------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL 251
Query: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
+E S A++ A I ++L + + ++ + E +++ ++E+ ++
Sbjct: 252 KDECKKLQSQYASSEATI-------SQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
+ L ++ ++Y + ++ SV + + + D + + S E R+
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
Query: 491 IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
+++ + + + L EL E + + + + E QH + ++ E+ Q +
Sbjct: 365 VELSEKGEATQKLKEELSEVETKY--QHLKAEFKQLQQQREEKEQHGLQLQS--EINQLH 420
Query: 551 QRLLVALRELGET--REREEQETTSSK-------ITELQLKLESALTEL-EQLRKSRQHQ 600
+LL R+LGE R +E+++ +S K + +LQLKL +L E++ S + Q
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 601 MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660
QL +Q+ + L Q+T + + L+ V K I
Sbjct: 481 HQL--DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK-------------I 525
Query: 661 ESTEAI--EAKAALKQLQEIFENY--KKEKAENEKIQNEQLEK----LQEQVTDLRSQNT 712
++ EA+ ++K + L++ E+ K + E E QL++ LQEQVT L
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL---TE 582
Query: 713 KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
K+ Q + + E L D V+ + + + +R L E +N + L + E
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL-------ETSVNELNSQLNESKE 635
Query: 773 KLAVAEVRAENLKKEKEMLKLSEVRLSQQR-----------ESLLAEQRGQNLLLTNLQT 821
K++ +++ +K + E+L +E + QR +L +Q+ N + T L
Sbjct: 636 KVSQLDIQ---IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 822 IQGILERSETETKQ--------------------RLSSQIEKLEH---EISHLKKKLENE 858
+ L+ + Q L QI+KLE E+ K++ +
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916
++Q+ L +L+++ + +QL+ E + +T+ L+ + + ++KQ L+ E Q+
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT-SLEES 975
Q + + E++++ + ++V KE L T S V+ + V+ SL+ S
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 976 ---LNKEKQVTEEVRKNIEVRLKE-SAEFQTQLEKKLMEVEKEKQELQDDKRRA------ 1025
KE Q + ++E KE + Q Q+E L E ++ K+ L+ +K +
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD---CQEQAKIAV----EA 1078
+ SM++QL + + TL + E Q+ + + +Q ++ Q + KIAV E
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERML 1138
+NK +++L A + L A KE++S + + + +ET ++ +S ++ + L
Sbjct: 993 ENKLQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049
Query: 1139 KDEVSKCVCRCEDLEKQNRLLHDQIEKLSD-KVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
K K EDL + +Q + + + K + E L E K+ + I
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 1198 EILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER-EKVQVTAKTM 1256
+ +EKE+ + ++A++E ++ RQ E+E+ +L + L + + E ++
Sbjct: 1110 KEKSL--KEKELVNEKSKLAEIEEIKCRQ-----EKEITKLNEELKSHKLESIKEITNLK 1162
Query: 1257 AQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE 1316
+ L+++ + ++ K E+++R +Q L+ +V+K E +E E E
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD---QVKKEE------EELKKEFIE 1213
Query: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
K L +E K E +K+ + N+ ++ Q E + E + +R+ +L ++
Sbjct: 1214 KEAKLHSEIKEKEVGMKKHE-ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV-KTITQVK 1435
L+ EIA A++ NNQ+ ++L E K E E +Q K++++Q K+ T V+
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ----TKVLELQRKLDNTTAAVQ 1328
Query: 1436 KIGR 1439
++GR
Sbjct: 1329 ELGR 1332
Score = 186 bits (472), Expect = 2e-46
Identities = 267/1363 (19%), Positives = 590/1363 (43%), Gaps = 142/1363 (10%)
Query: 255 EDLLTKLKEAKEQQASM-EEKFHNELNAHIKLSNLYKSAADDSEAKSNEL-TRAVEELHK 312
+D+ +E ++ QAS+ EEK+++E +K EAK + L T + EL
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSE---ELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
Query: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEK---EMLEKIGRLEKELENANDLLSATKRKGAI 369
L ++ EA Q ++Q KD E+ ++ +I ++ + + L A ++K
Sbjct: 140 LEQQLEEA----QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195
Query: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
L+EE ++ A + + TEL +D +L+K E ++ +D + E
Sbjct: 196 LTEE----LNKEATVIQDLK------TELLQR-PGIEDVAVLKK-ELVQVQTLMDNMTLE 243
Query: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRM 489
E ++ LK +E ++ Q AS + Q E+ K ++ +V ++ +++
Sbjct: 244 RERESEKLK---DECKKLQSQYASSEATISQLRSELA-------KGPQEVAVYVQELQKL 293
Query: 490 EIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
+ V +L+Q+ + L L + ++ +E+ + +S + + H + ++LQ +
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL-DCQQLQSR 352
Query: 550 NQ-------RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
R+ V L E GE ++ ++E ++E++ K + E +QL++ R+ + Q
Sbjct: 353 LSASETSLHRIHVELSEKGEATQKLKEE-----LSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
+ + + L +T H + L+S Q + +E
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467
Query: 663 TEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS 722
+ E +LQ + K++ E + +Q KL+E DL ++ Q+
Sbjct: 468 -QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE----QVLRQIGDKD 522
Query: 723 KRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR-A 781
++ + L+ ++ + I+ L + + L A Q E + Q L+ N L +
Sbjct: 523 QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLT 581
Query: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
E LK + E K ++ L Q + A R + +L+T L E+K+++S
Sbjct: 582 EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLD 641
Query: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDVQ---LLDTKRQLDTETNLHLNTKELLKNAQ 898
+++ + L + QR L +LD L D +++L+ T L++ Q
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
Query: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
+ + L+ HL + + S ++ ++L Q+++ E ++K + +
Sbjct: 702 EHCSQLESHLKEYKEKYLSL------------EQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 959 TSNVEQYQAMVTSLE---ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
+++Q + + T LE L+K+ ++ +E+ + + L++ +E +++KL + E+EK
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075
Q L+ D + + Q EL + + E+Q+
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKV------------------------- 844
Query: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMA----SVRQHLEETTQKAESQLLECKASW 1131
K E+E ++ L K+++SK++ + + E+ QK ++ +L+ + +
Sbjct: 845 -----KMEKEALM-----TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894
Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
+E + L+ ++ + ++L+K + +L ++ + ++ +Q +L + K
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEK 952
Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVE-SLRYRQRVEL---LERELQELQDSLNAERE 1247
++Q+ + +++ E + + E Q E + Q+ EL L+++L + L AE+E
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
K+ V + +E K+ ++ E+ E QDL+ ++ K+ + D++
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRES------ELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEV--HT 1365
+ ++ L+ K LE+D + + Q L + K + K L EKE+
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAK---KEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK--DLDAKIID 1423
++ ++ E R + EI + N L +++ ++S+KE N ++ IQ+ +L K
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHK--LESIKEITNLKDAKQLLIQQKLELQGKADS 1181
Query: 1424 IQEKVKTITQVKKIGR-RYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
++ V+ + ++I + + K + EELK + +E A+ + +E+ V +++ +E +
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKE---FIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
L T +L + ++K + L++QT L+ E++ L +Q+ + L
Sbjct: 1239 LTMQIT---ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Query: 1543 RQQITEKE---EKTRKAIVAAKSKIAHLAGVKDQLTKENEELK 1582
++ + E EK + ++ + K+ + +L +EN+ L+
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 163 bits (413), Expect = 2e-39
Identities = 223/1060 (21%), Positives = 482/1060 (45%), Gaps = 122/1060 (11%)
Query: 664 EAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-------------LEKLQEQVTDLRSQ 710
E + +A+LK+ + E KKE + + +Q ++ L+ L++Q+ + +++
Sbjct: 91 EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 150
Query: 711 NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
N I D ++ L + +I S ++ + L + EQ + +T++L
Sbjct: 151 NFNIKQMKDLFEQKAAQLATEIA----DIKSKYDEERSLR---EAAEQKVTRLTEELN-- 201
Query: 771 NEKLAVAEVRAENLKK----EKEMLKLSEVRLSQQRESLLAE-QRGQNLLLTNLQTIQGI 825
E + +++ E L++ + +LK V++ +++ E +R L + +Q
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLE------NEVEQRH-TLTRNL-----DVQL 873
SE Q L S++ K E++ ++L+ NE+ Q++ TLT NL D
Sbjct: 262 YASSEATISQ-LRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 874 LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
L+ K + E+ N + L + L+ LS E + + + KG+ + K
Sbjct: 321 LEEKH--NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK-- 376
Query: 934 VDDLVSQLRQTEEQVNDLK---ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
L +L + E + LK ++L+ EQ+ + S L+ + TE
Sbjct: 377 ---LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 991 EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLS---ELKKTLSSV--QN 1045
RLKE + ++ KLM+ E++ +LQ R E ++++++ EL+ L Q+
Sbjct: 434 HGRLKEQRQLSSE---KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 1046 EVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL-QAAKEQVS 1104
+ Q+ALQ+++TA E A+ D ++ + + K + ++EAL Q +KE +S
Sbjct: 491 QEQQALQQSTTAKLRE--AQNDLEQVLRQIGDKDQKIQ--------NLEALLQKSKENIS 540
Query: 1105 KMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRL----LH 1160
+ R+ L Q E + +E+ L+++V++ + ++ + ++ LH
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599
Query: 1161 DQIEKLSDKVVASVKE--GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQ 1218
DQ+++ + A+ ++ +N S+ +S+E++ ++ I+ + E+ +
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 1219 VESLRYRQRVELLERELQELQDSLNAEREKV-QVTAKTMAQHEELMKKTETMNVVMETNK 1277
+ + ++ + LQ+ Q LN ++ QVTAK L K E + + K
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-------LQDKQEHCSQLESHLK 712
Query: 1278 MLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE---KSGMLQAEKKLLEEDVKR 1334
+E+ LEQ ++++ +++KLE D L ++ + + + + L + +L ++ +
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 1335 WKARNQHLVS------QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388
+ +VS Q+K E ++ L+++E + Q L ++ L E +
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE---EEKQILKQDFETLSQETKIQHEE 829
Query: 1389 LTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQ-VKKIGRRYKTQYEE 1447
L N IQ+ +L KV+ EKE + +L +++K+ ++ +K ++ + ++
Sbjct: 830 LNNR---IQTTVTELQKVKMEKEALMTELST----VKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 1448 LKAQQDKVMETSAQSSGDHQEQ-HVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
KA + +T + Q Q +++E +ELK++L + + S L+ ++ ++Q+ L +
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH 1566
+ + +++ QLQ ++ L+Q + + Q E L+ ++ K V K+++ +
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL--------KIAVLQKTELEN 994
Query: 1567 LAGVKDQLTKENEEL---KQRNGALDQQKDELDVRITALKSQYEGRISRL---ERELREH 1620
++ QLT+ +EL K++ L ++ L+S + GR S L ++L+
Sbjct: 995 --KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQI-TLKTTPASGERGIA 1659
+E+ +++ N++ Q + I LKT A+ E+ A
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Score = 159 bits (403), Expect = 2e-38
Identities = 245/1229 (19%), Positives = 517/1229 (42%), Gaps = 191/1229 (15%)
Query: 14 LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR 73
L K VQ ++ +++ E + LK +K + QY E +S + L +
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKL----QSQYASSEATISQLRSELAKGPQ 281
Query: 74 ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER 133
E EL+KL + + LT+KN+ L + + + +T+ +E+ E + +
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLT---ENLLKKEQDYTKLEEKHNEESV----SKKN 334
Query: 134 LSQELEYLTEDVKRLNEKLKESNTT----------KGELQLKLDELQASDVSVKYRE--- 180
+ L D ++L +L S T+ KGE KL E + S+V KY+
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKA 393
Query: 181 --KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN-------LENKKE 231
K+L+Q++E L +E+ +LL R+ G LK L +K++
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 232 EV-------SRLEEQMNGLKTSNEHLQKHV--------------EDLLTKLKEAK----- 265
+V SRLEEQ+ T++ LQ + + KL+EA+
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 266 ----------------------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
++ S+ EK +L A I+ + + + K++ L
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
V +L + LK E++K Q++L + Q + + +++ LE + N L+ +
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL 423
K K +S+ ++ + T ++ + +L N Q+ L ++ E +I L
Sbjct: 634 KEK---VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 424 DEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDT--DKANKQSSV 481
D++ +++ K + + ++ SL K E+ +I++L+ D+ KA+K+ ++
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 482 LERDNRR-----MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH 536
+ +R +E++ +LS+Q +E+E+ ++ + S + E I Q
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQ-----LEMEK----EIVSSTRLDLQKKSEALESIKQK 801
Query: 537 LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKS 596
L +++ +Q+ L ++ +TT +++ +++++ E+ +TEL ++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK-- 859
Query: 597 RQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
D + + D + S+ A+ LD L T K
Sbjct: 860 --------DKLSKVSDSLKNSKSEFEKENQKGKAAILD---LEKTCKE------------ 896
Query: 657 VPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKIST 716
++ ++ + LK+ +E+ ++ +KEK + +++ E L +QEQ+ +++QNT
Sbjct: 897 ---LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE-LNSMQEQL--IQAQNT---- 946
Query: 717 QLDFASKRYEMLQDNV-------EGYRREITSLHERNQ----KLTATTQKQEQIINTMTQ 765
L K + LQ N+ E +++I +L + + T K +Q + Q
Sbjct: 947 -LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQ 1005
Query: 766 DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG- 824
+L EK++V + N +K +E K + + LLA ++ + L Q
Sbjct: 1006 ELAAEKEKISVLQ---NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 825 -ILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
I R++ + +L +++ + + K E ++++R +++ + +++L E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 884 TNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQ 943
+ +E+ +KEI L + L + +++ + +N +D L+ Q
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI---------TNLKDAKQLLIQ--- 1170
Query: 944 TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
Q +L+ + + + VEQ + L++ + KE+ EE++K +++ A+ ++
Sbjct: 1171 ---QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE---EELKKEF---IEKEAKLHSE 1221
Query: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
+++K EV +K E + K + Q++ L + L +V+ E Q + +R S E+Q
Sbjct: 1222 IKEK--EVGMKKHEENEAK------LTMQITALNENLGTVKKEWQSSQRRVSEL---EKQ 1270
Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKA--- 1120
E A + QN + L ++ ++ +K+ +++ L+ TT
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Query: 1121 --ESQLLECKASWEERERMLKD-EVSKCV 1146
E+Q L+ K + + +D EV C+
Sbjct: 1331 GRENQSLQIKHTQALNRKWAEDNEVQNCM 1359
Score = 94.7 bits (234), Expect = 9e-19
Identities = 113/532 (21%), Positives = 230/532 (43%), Gaps = 42/532 (7%)
Query: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
R +L K +++++ +K L Q+ E LK E E++ Q+ E+ R+ + L
Sbjct: 785 RLDLQKKSEALESIKQK-LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 71 ETRECQSLRLELEKLNNQLKALTE--KNKELEIAQDRNIA-----------------IQS 111
E ++L EL + ++L +++ KN + E ++ +Q
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 112 QFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168
Q T +E + K+ L + E +L EL + E + + LK++ + +LQ ++E
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 169 LQASDVSVKYREKRLEQEKELLHSQNTWLNTELK---TKTDELLALGREKGNEILELKCN 225
L+ S K + + L+ E ++ Q T L +L+ T+ + LA +EK I L+ N
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK---ISVLQNN 1020
Query: 226 LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKL 285
E +E +L+ G ++ ++ ++ + KL A+E S + N+ +L
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 286 SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI---QDHLLEVEQSKDQMEKEM 342
+ DS K +L + L + KE K + + L E+E+ K + EKE+
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 343 LEKIGRLEK-ELENANDLLSATKRKGAILSEE-ELAAMSPTAAAVAKIVKPGMKLTELYN 400
+ L+ +LE+ ++ + K ++ ++ EL + + A + K ++ L +
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI--LKD 1198
Query: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ 460
+ +++L E +E + ++ E++ K +K+ E + + +L+ L
Sbjct: 1199 QVKKEEEELKKEFIEKEA------KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 461 AMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
KE Q Q + KQ+ L + +E V++ + R LL + G
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
Score = 82.0 bits (201), Expect = 6e-15
Identities = 177/948 (18%), Positives = 369/948 (38%), Gaps = 143/948 (15%)
Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS-- 1192
E + + K + ++L K +HD A G G N++L + +
Sbjct: 39 EGFICPQCMKSLGSADELFKHYEAVHD----------AGNDSGHGGESNLALKRDDVTLL 88
Query: 1193 QEQILEILRFIRREKEIAET-RFEVAQVESLRYRQRVE--LLERELQELQDSLNAEREKV 1249
++++ ++ ++ EK +E + E+ + + L+ ++ L+ ELQ SL + E+
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ-SLEQQLEEA 147
Query: 1250 QVTAKTMAQHEELM--KKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
Q + Q ++L K + + + EE+ E Q++ +L + +
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDV---KRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364
Q+ EL ++ G+ EDV K+ + Q L+ E KL E +
Sbjct: 208 QDLKTELLQRPGI---------EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424
+ I +L++E+A+ + +Q LK +N++ + +T+ ++L K D
Sbjct: 259 QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
Query: 1425 Q--EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGD--HQEQHVSVQEMQELK 1480
E+ V K + ++L QQ + +++++S H E + Q+LK
Sbjct: 319 TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
Query: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQ------------------------- 1515
E L++ ETK + L+++ + LQ+ EKE LQ
Sbjct: 379 EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438
Query: 1516 --------------EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
+Q LQ +LSRL + L+++ T +L+ Q+ + +++ ++ +
Sbjct: 439 EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498
Query: 1562 SKIAHL-------------AGVKDQLTKENEELKQRN----GALDQQKDELDVRI----- 1599
S A L G KDQ + E L Q++ L++++++L +I
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 1600 -TALKSQYEGR-------ISRLERELREHQERHLEQR----DEPQEPSNKVPEQQRQITL 1647
TA+ +Q + + +++L +L+ E H + + D+ QE + Q ++
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 1648 KTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPA--- 1704
T + + S + + T ++A A K+ RA ++ + A
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA---KTAQRADLQNHLDTAQNA 675
Query: 1705 -----TVTNPTTTPTATVMPTTQVESQEAMQSEGPV-EHVPVFGSTSGSVRSTSPNVQPS 1758
N TT V Q + + Q E + E+ + S ++
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 1759 ISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNI---VEVVQSSPVERPSTSTAV 1815
+ + + QA +Q +Q + +E ELS + E+V S+ ++ S A+
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 1816 FGTVSATPSSSLPKRTREEEED-------STIEASDQVSDDTVEMPLPKKLKSVTPVGTE 1868
S K T++EEE T+ ++ + + + + + V E
Sbjct: 796 --------ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 1869 EE-VMAEESTDGEVETQVYNQ-DSQDSIGEGVTQGDYTPMEDSEET----SQSLQIDLGP 1922
+E +M E ST + ++V + + S E Q + D E+T LQ+ +
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 1923 LQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEE 1970
+Q+ S + + + + ++ + +E + + E++E+
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Score = 60.5 bits (145), Expect = 2e-08
Identities = 84/354 (23%), Positives = 163/354 (46%), Gaps = 37/354 (10%)
Query: 8 VLERTEL-NKLPKSVQNKLEKFLADQQSEIDGLKGRHEK----FK-------------VE 49
VL++TEL NKL + + ++ LA ++ +I L+ +EK FK +
Sbjct: 986 VLQKTELENKLQQQLTQAAQE-LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 50 SEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN-KELEIAQDRNIA 108
+ Q +E++LS +QE L++ + + +++L L + + K+ + Q+R A
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 109 ---IQSQFTRTKEELEAEKRDLIRTNE---RLSQELEYLTEDVKRLN-EKLKESNTTKGE 161
IQ + + ++EL EK L E R +E+ L E++K E +KE K
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164
Query: 162 LQLKLD---ELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA-LGREKGN 217
QL + ELQ S+K ++ ++ +++L Q ELK + E A L E
Sbjct: 1165 KQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE 1224
Query: 218 EILELKCNLENKKE---EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
+ + +K + EN+ + +++ L E + +K + Q+ V +L + + + + A +E
Sbjct: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284
Query: 275 FHN---ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
N E A ++ + + + K EL R ++ ++E G N+++Q
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 970
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1031 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1086
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1144
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1261
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1262 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1554 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1605
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1726 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2138
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2194
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2195 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2250
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2251 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2368
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2418
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2419 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2476
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2477 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2589
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSE 2613
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1679
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1680 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1732
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1844
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1959
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1960 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2015 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2062
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2063 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2111 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2270
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2566 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1060 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1118 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1177 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1277
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1278 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1384
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1439
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1500 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1616 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1667
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1728 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1843
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1844 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2142 AEQEAARRAQAEQA 2155
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 977
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 978 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1031
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1150
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1266
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1321
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1322 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1371
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1372 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1543
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2120
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2416
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2477 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2521 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2215 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2394 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2622
Score = 39.7 bits (91), Expect = 0.035
Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q +++N D+ N KL + + L ++S++++S Q E + A+++ L
Sbjct: 113 RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 164
Query: 815 LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
LL + + ++G R + T S + +L + I H K L ++ + R T NLD
Sbjct: 165 LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 221
Query: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
+R L L ++ + +K I T L + +V Q R + Q
Sbjct: 222 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 281
Query: 931 KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
+E + ++ L+ +ER +S +E + +E K+ + K
Sbjct: 282 QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 341
Query: 990 IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
I L+ ++ + + ++VEKE +L AI E+QL + E
Sbjct: 342 IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 389
Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
E LQR T L E C+EQ A L +DV L A K V +
Sbjct: 390 RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 434
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
A +E KA+S + R+L ++V + Q ++ ++ +L
Sbjct: 435 AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 477
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++VA ++ N +R + +A +VAQV ++
Sbjct: 478 HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 513
Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
R EL + L+ LQD L E + +V A+ + + + + ++ + R + E
Sbjct: 514 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573
Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
R D Q+ R D L LQ A S K S + A K+L+
Sbjct: 574 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633
Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
EE+V W RN ++ +++ E Y L+ E E+ K+I++L RL E
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
+ ++ + Q +Q+ + ++ E K+ A + + Q++K+ + +
Sbjct: 689 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 748
Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
Y ++ +E Q + D +EQ
Sbjct: 749 YSCDRSATVTRLEDLLQDAQDEKEQ 773
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4448 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4508 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4544
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 919 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 974
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 975 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1034
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1035 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1090
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1091 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1148
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1265
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1266 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1377
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1497
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1558 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1609
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1610 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1730 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2142
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2198
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2199 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2254
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2255 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2372
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2373 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2422
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2423 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2480
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2481 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2593
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHSE 2617
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1683
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1684 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1736
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1848
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1963
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1964 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2019 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2066
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2067 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2115 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2160
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2274
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2331
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2332 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2391
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2449
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2570 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1064 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1122 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1181 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1228
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1281
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1282 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1388
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1443
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1444 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1504 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1619
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1620 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1671
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1732 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1847
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1848 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2146 AEQEAARRAQAEQA 2159
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 866 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 926 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 981
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 982 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1035
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1094
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1095 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1154
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1270
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1271 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1325
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1326 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1375
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1376 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1435
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1547
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2124
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2420
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2481 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2525 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2219 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2337
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2338 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2398 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2626
Score = 40.8 bits (94), Expect = 0.016
Identities = 174/829 (20%), Positives = 320/829 (38%), Gaps = 119/829 (14%)
Query: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
+QL + E + +K K N+ L K Q ++DL + + S + D++
Sbjct: 36 QQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYED---LRDGHNLISLLEVLSGDSL 92
Query: 733 --EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM 790
E R L L +Q +++N D+ N KL + + L
Sbjct: 93 PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILH----- 147
Query: 791 LKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEIS 849
++S++++S Q E + A+++ LLL + + ++G R + T S + +L + I
Sbjct: 148 FQISDIQVSGQSEDMTAKEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAII 201
Query: 850 HLKKKLENEVEQ--RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907
H K L ++ + R T NLD +R L L ++ + +K I T
Sbjct: 202 HRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSS 261
Query: 908 LSNMEVQVAS-QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQY 965
L + +V Q R + Q +E + ++ L+ +ER +S +E
Sbjct: 262 LYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 321
Query: 966 QAMVTSLEESLNKEKQVTEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDK 1022
+ +E K+ + K I L+ ++ + + ++VEKE +L
Sbjct: 322 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-- 379
Query: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY 1082
AI E+QL + E E LQR T L E C+EQ A
Sbjct: 380 --AILEREKQLRS--------EFERLECLQRIVTKLQMEAGL---CEEQLNQADA----- 421
Query: 1083 ERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
L +DV L A K V + A +E KA+S + R+L ++V
Sbjct: 422 -----LLQSDVRLLAAGK--VPQRAG---EVERDLDKADSMI-----------RLLFNDV 460
Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRF 1202
+ Q ++ ++ +L +++VA ++ N
Sbjct: 461 QTLK---DGRHPQGEQMYRRVYRLHERLVA-----IRTEYN------------------- 493
Query: 1203 IRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AKTMAQHE 1260
+R + +A +VAQV ++R EL + L+ LQD L E + +V A+
Sbjct: 494 LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLP 553
Query: 1261 ELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK 1317
+ + + + ++ + R + ER D Q+ R D L LQ A S K
Sbjct: 554 SVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSK 613
Query: 1318 ----------SGMLQAEKKLL------EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSE 1360
S + A K+L+ EE+V W RN ++ +++ E Y L+ E
Sbjct: 614 ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRE 668
Query: 1361 KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK 1420
E+ K+I++L RL E + ++ + Q +Q+ + ++ E K+ A
Sbjct: 669 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 728
Query: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
+ + Q++K+ + +Y ++ +E Q + D +EQ
Sbjct: 729 FQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 777
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4452 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4511
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4512 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4548
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 970
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 971 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1030
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1031 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1086
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1144
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1261
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1262 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1554 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1605
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1726 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2138
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2194
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2195 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2250
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2251 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2368
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2369 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2418
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2419 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2476
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2477 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2589
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSE 2613
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1679
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1680 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1732
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1844
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1959
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1960 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2015 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2062
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2063 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2111 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2156
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2270
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2328 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2387
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2445
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2566 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1060 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1118 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1177 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1277
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1278 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1384
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1439
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1440 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1500 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1616 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1667
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1728 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1843
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1844 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2142 AEQEAARRAQAEQA 2155
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 977
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 978 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1031
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1090
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1091 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1150
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1266
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1321
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1322 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1371
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1372 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1543
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2120
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2416
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2477 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2521 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2215 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2394 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2622
Score = 39.7 bits (91), Expect = 0.035
Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q +++N D+ N KL + + L ++S++++S Q E + A+++ L
Sbjct: 113 RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 164
Query: 815 LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
LL + + ++G R + T S + +L + I H K L ++ + R T NLD
Sbjct: 165 LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 221
Query: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
+R L L ++ + +K I T L + +V Q R + Q
Sbjct: 222 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 281
Query: 931 KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
+E + ++ L+ +ER +S +E + +E K+ + K
Sbjct: 282 QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 341
Query: 990 IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
I L+ ++ + + ++VEKE +L AI E+QL + E
Sbjct: 342 IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 389
Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
E LQR T L E C+EQ A L +DV L A K V +
Sbjct: 390 RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 434
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
A +E KA+S + R+L ++V + Q ++ ++ +L
Sbjct: 435 AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 477
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++VA ++ N +R + +A +VAQV ++
Sbjct: 478 HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 513
Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
R EL + L+ LQD L E + +V A+ + + + + ++ + R + E
Sbjct: 514 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573
Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
R D Q+ R D L LQ A S K S + A K+L+
Sbjct: 574 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633
Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
EE+V W RN ++ +++ E Y L+ E E+ K+I++L RL E
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
+ ++ + Q +Q+ + ++ E K+ A + + Q++K+ + +
Sbjct: 689 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 748
Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
Y ++ +E Q + D +EQ
Sbjct: 749 YSCDRSATVTRLEDLLQDAQDEKEQ 773
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4448 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4508 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4544
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 883 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 938
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 939 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 998
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 999 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1054
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1055 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1112
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1229
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1230 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1341
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1461
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1522 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1573
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1574 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1694 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 1991
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2106
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2162
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2163 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2218
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2219 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2336
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2337 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2386
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2387 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2444
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2445 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2557
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHSE 2581
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1647
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1648 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1700
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1812
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1927
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1928 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 1983 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2030
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2031 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2079 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2124
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2238
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2295
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2296 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2355
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2413
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2534 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1028 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1086 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1145 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1192
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1245
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1246 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1352
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1407
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1408 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1468 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1583
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1584 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1635
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1696 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1811
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1812 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2110 AEQEAARRAQAEQA 2123
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 830 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 890 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 945
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 946 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 999
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1058
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1059 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1118
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1234
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1235 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1289
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1290 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1339
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1340 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1399
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1511
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2088
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2384
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2445 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2489 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2183 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2301
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2302 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2362 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2590
Score = 39.7 bits (91), Expect = 0.035
Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q +++N D+ N KL + + L ++S++++S Q E + A+++ L
Sbjct: 81 RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 132
Query: 815 LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
LL + + ++G R + T S + +L + I H K L ++ + R T NLD
Sbjct: 133 LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 189
Query: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
+R L L ++ + +K I T L + +V Q R + Q
Sbjct: 190 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 249
Query: 931 KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
+E + ++ L+ +ER +S +E + +E K+ + K
Sbjct: 250 QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 309
Query: 990 IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
I L+ ++ + + ++VEKE +L AI E+QL + E
Sbjct: 310 IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 357
Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
E LQR T L E C+EQ A L +DV L A K V +
Sbjct: 358 RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 402
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
A +E KA+S + R+L ++V + Q ++ ++ +L
Sbjct: 403 AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 445
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++VA ++ N +R + +A +VAQV ++
Sbjct: 446 HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 481
Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
R EL + L+ LQD L E + +V A+ + + + + ++ + R + E
Sbjct: 482 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 541
Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
R D Q+ R D L LQ A S K S + A K+L+
Sbjct: 542 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601
Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
EE+V W RN ++ +++ E Y L+ E E+ K+I++L RL E
Sbjct: 602 EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 656
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
+ ++ + Q +Q+ + ++ E K+ A + + Q++K+ + +
Sbjct: 657 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 716
Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
Y ++ +E Q + D +EQ
Sbjct: 717 YSCDRSATVTRLEDLLQDAQDEKEQ 741
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4416 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4475
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4476 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4512
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 1107
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 1108 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1167
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1168 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1223
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1224 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1281
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1398
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1399 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1510
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1630
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1691 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1742
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1743 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1863 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2275
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2331
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2332 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2387
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2388 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2505
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2506 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2555
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2556 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2613
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2614 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2726
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHSE 2750
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1816
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1817 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1869
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1981
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 2096
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 2097 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2152 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2199
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2200 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2248 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2293
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2407
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2464
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2465 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2524
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2582
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2703 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1197 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1255 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1314 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1361
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1414
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1415 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1521
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1576
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1637 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1752
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1753 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1804
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1865 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1980
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1981 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2279 AEQEAARRAQAEQA 2292
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 1114
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 1115 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1168
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1227
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1228 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1287
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1403
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1404 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1458
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1459 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1508
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1509 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1680
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2257
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2438 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2553
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2614 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2658 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2352 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2470
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2471 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2531 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2759
Score = 43.9 bits (102), Expect = 0.002
Identities = 182/872 (20%), Positives = 333/872 (38%), Gaps = 141/872 (16%)
Query: 633 LDDVSLASTPKRPSTSQTVST---PAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAEN 689
L++VS TP P+T+Q P P P + + ++ K K +
Sbjct: 145 LEEVS-PETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWV-------------- 189
Query: 690 EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV--EGYRREITSLHERNQ 747
N+ L K Q ++DL + + S + D++ E R L
Sbjct: 190 ----NKHLIKAQRHISDLYED---LRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQI 242
Query: 748 KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
L +Q +++N D+ N KL + + L ++S++++S Q E + A
Sbjct: 243 ALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTA 297
Query: 808 EQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHT 864
+++ LLL + + ++G R + T S + +L + I H K L ++ + R T
Sbjct: 298 KEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351
Query: 865 LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRT 923
NLD +R L L ++ + +K I T L + +V Q R
Sbjct: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA 411
Query: 924 GKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQV 982
+ Q +E + ++ L+ +ER +S +E + +E K+
Sbjct: 412 NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEA 471
Query: 983 TEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKT 1039
+ K I L+ ++ + + ++VEKE +L AI E+QL
Sbjct: 472 DKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS---- 523
Query: 1040 LSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAA 1099
+ E E LQR T L E C+EQ A L +DV L A
Sbjct: 524 ----EFERLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAG 566
Query: 1100 KEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLL 1159
K V + A +E KA+S + R+L ++V + Q +
Sbjct: 567 K--VPQRAG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQM 607
Query: 1160 HDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQV 1219
+ ++ +L +++VA ++ N +R + +A +VAQV
Sbjct: 608 YRRVYRLHERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQV 643
Query: 1220 ESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNK 1277
++R EL + L+ LQD L E + +V A+ + + + + ++ +
Sbjct: 644 TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 703
Query: 1278 MLREEKERLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAE 1324
R + ER D Q+ R D L LQ A S K S + A
Sbjct: 704 EFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAAT 763
Query: 1325 KKLL------EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR 1377
K+L+ EE+V W RN ++ +++ E Y L+ E E+ K+I++L R
Sbjct: 764 KELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDR 818
Query: 1378 LKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI 1437
L E + ++ + Q +Q+ + ++ E K+ A + + Q++K+
Sbjct: 819 LLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL 878
Query: 1438 GRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
+ +Y ++ +E Q + D +EQ
Sbjct: 879 QEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 910
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4585 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4645 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4681
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 893 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 948
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 949 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1008
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1009 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1064
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1065 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1122
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1239
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1240 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1351
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1471
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1532 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1583
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1584 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1704 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2116
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2172
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2173 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2228
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2229 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2346
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2347 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2396
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2397 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2454
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2455 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2567
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHSE 2591
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1657
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1658 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1710
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1822
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1883 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1937
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1938 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 1993 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2040
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2041 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2089 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2134
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2248
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2305
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2306 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2365
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2423
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2544 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1038 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1096 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1155 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1202
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1255
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1256 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1362
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1417
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1478 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1593
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1594 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1645
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1706 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1821
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1822 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2120 AEQEAARRAQAEQA 2133
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 840 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 900 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 955
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 956 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1009
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1068
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1069 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1128
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1244
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1245 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1299
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1300 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1349
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1350 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1521
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1576
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2098
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2279 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2394
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2455 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2499 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2193 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2311
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2312 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2372 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2600
Score = 39.7 bits (91), Expect = 0.035
Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q +++N D+ N KL + + L ++S++++S Q E + A+++ L
Sbjct: 91 RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 142
Query: 815 LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
LL + + ++G R + T S + +L + I H K L ++ + R T NLD
Sbjct: 143 LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 199
Query: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
+R L L ++ + +K I T L + +V Q R + Q
Sbjct: 200 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 259
Query: 931 KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
+E + ++ L+ +ER +S +E + +E K+ + K
Sbjct: 260 QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 319
Query: 990 IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
I L+ ++ + + ++VEKE +L AI E+QL + E
Sbjct: 320 IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 367
Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
E LQR T L E C+EQ A L +DV L A K V +
Sbjct: 368 RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 412
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
A +E KA+S + R+L ++V + Q ++ ++ +L
Sbjct: 413 AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 455
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++VA ++ N +R + +A +VAQV ++
Sbjct: 456 HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 491
Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
R EL + L+ LQD L E + +V A+ + + + + ++ + R + E
Sbjct: 492 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551
Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
R D Q+ R D L LQ A S K S + A K+L+
Sbjct: 552 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611
Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
EE+V W RN ++ +++ E Y L+ E E+ K+I++L RL E
Sbjct: 612 EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
+ ++ + Q +Q+ + ++ E K+ A + + Q++K+ + +
Sbjct: 667 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 726
Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
Y ++ +E Q + D +EQ
Sbjct: 727 YSCDRSATVTRLEDLLQDAQDEKEQ 751
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4426 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4486 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4522
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 901 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 956
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 957 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1016
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1017 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1072
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1073 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1130
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1247
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1248 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1359
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1479
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1540 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1591
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1592 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1712 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2009
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2124
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2180
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2181 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2236
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2237 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2354
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2355 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2404
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2405 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2462
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2463 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2575
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2576 ENQRLREQLQLLEEQHRAALAHSE 2599
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1665
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1666 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1718
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1830
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1945
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1946 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2001 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2048
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2049 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2097 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2142
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2256
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2313
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2314 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2373
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2431
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2552 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1046 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1104 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1163 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1210
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1263
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1264 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1370
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1425
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1426 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1486 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1601
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1602 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1653
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1714 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1829
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1830 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2128 AEQEAARRAQAEQA 2141
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 848 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 908 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 963
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 964 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1017
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1076
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1077 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1136
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1196
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1252
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1253 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1307
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1308 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1357
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1358 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1529
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1584
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2106
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2287 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2402
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2463 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2507 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2201 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2319
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2320 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2380 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2608
Score = 43.5 bits (101), Expect = 0.002
Identities = 175/835 (20%), Positives = 323/835 (38%), Gaps = 124/835 (14%)
Query: 672 LKQLQEIFENYKKEKAENEKIQ-----NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
++ +E+ E YK E+ +K N+ L K Q ++DL + + S
Sbjct: 12 IQAYEEVREKYKDERDRVQKKTFTKWVNKHLIKAQRHISDLYED---LRDGHNLISLLEV 68
Query: 727 MLQDNV--EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
+ D++ E R L L +Q +++N D+ N KL + + L
Sbjct: 69 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 128
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEK 843
++S++++S Q E + A+++ LLL + + ++G R + T S + +
Sbjct: 129 H-----FQISDIQVSGQSEDMTAKEK---LLLWSQRMVEGYQGLRCDNFTS---SWRDGR 177
Query: 844 LEHEISHLKKKLENEVEQ--RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEI 901
L + I H K L ++ + R T NLD +R L L ++ + +K I
Sbjct: 178 LFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSI 237
Query: 902 ATLKQHLSNMEVQVAS-QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER-LKTST 959
T L + +V Q R + Q +E + ++ L+ +ER +S
Sbjct: 238 ITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSF 297
Query: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK---ESAEFQTQLEKKLMEVEKEKQ 1016
+E + +E K+ + K I L+ ++ + + ++VEKE
Sbjct: 298 EEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWG 357
Query: 1017 ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV 1076
+L AI E+QL + E E LQR T L E C+EQ A
Sbjct: 358 KLHV----AILEREKQLRS--------EFERLECLQRIVTKLQMEAGL---CEEQLNQAD 402
Query: 1077 EAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
L +DV L A K V + A +E KA+S + R
Sbjct: 403 A----------LLQSDVRLLAAGK--VPQRAG---EVERDLDKADSMI-----------R 436
Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
+L ++V + Q ++ ++ +L +++VA ++ N
Sbjct: 437 LLFNDVQTLK---DGRHPQGEQMYRRVYRLHERLVA-----IRTEYN------------- 475
Query: 1197 LEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN-AEREKVQVT-AK 1254
+R + +A +VAQV ++R EL + L+ LQD L E + +V A+
Sbjct: 476 ------LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAE 529
Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI---LPLQEAN 1311
+ + + + ++ + R + ER D Q+ R D L LQ A
Sbjct: 530 WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 589
Query: 1312 AELSEK----------SGMLQAEKKLL------EEDVK-RWKARNQHLVSQQKDPDTEEY 1354
S K S + A K+L+ EE+V W RN ++ +++ E Y
Sbjct: 590 LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK-----ESY 644
Query: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
L+ E E+ K+I++L RL E + ++ + Q +Q+ + ++ E
Sbjct: 645 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 704
Query: 1415 KDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
K+ A + + Q++K+ + +Y ++ +E Q + D +EQ
Sbjct: 705 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 759
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4434 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4493
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4494 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4530
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 206 bits (524), Expect = 2e-52
Identities = 372/1764 (21%), Positives = 734/1764 (41%), Gaps = 221/1764 (12%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSH 63
+ L+ E + S++ + FL D Q G + ++ +E++Y ++L
Sbjct: 942 RTLKPEEQRQALHSLELHYQAFLRDSQDA----GGFGPEDRLMAEREYGSCSHHYQQLLQ 997
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQ-SQFTRTKEELE 121
S E+ E CQ EL+ + QL+A T L + D+ A + +Q +++ +
Sbjct: 998 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1057
Query: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL-QASDVSVKYRE 180
AE L + RLS E E V L E + T + EL+L L +L Q +S Y E
Sbjct: 1058 AEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE 1113
Query: 181 KR---------LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
K + +E+L + L E + L L K + + +L+ E ++
Sbjct: 1114 KLKTISLVIRGTQGAEEVLRAHEEQLK-EAQAVPATLPELEATKAS-LKKLRAQAEAQQP 1171
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH----------NELNA 281
L +++ G + E LQ+ + +++ +E+ A + E++ EL
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK- 340
+ Y+ +AD A + R E++ + +A +++ L + + +++E+
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA---VREQLRQEQALLEEIERH 1288
Query: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +E+ R K+ NA K L A A+ AK K +
Sbjct: 1289 GEKVEECQRFAKQYINAI--------KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340
Query: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR-EEYERAQKAVASLSVKL 458
YV+ + + K++ E ++ +E + + ++QR EE ER + A+L +
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1400
Query: 459 EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
+ A Q + +A + ++ + R E D QQ R + EL++ R +
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460
Query: 519 E-EVSSADISSSSEVISQHLVSYRNIEELQQQNQR--------LLVALRELGETREREEQ 569
+ + A+ + S + + + ++ + QR L A E E ++R+ Q
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1520
Query: 570 ETT----------SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLS 619
E S + + +++L S + + + +Q +Q ++ + Q + L
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580
Query: 620 QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAK-----AALKQ 674
Q + + V+L T +R + ++ S A E T +E A+ Q
Sbjct: 1581 QAE-----VERARQVQVAL-ETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQ 1632
Query: 675 LQEIFENYKKEKAENEKIQNE---QLEKLQEQVTD---LRSQNTKISTQLDFASKRYEML 728
L+E E +++AE E+ + E +LE+ Q + + LR Q +++ Q A E
Sbjct: 1633 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
Query: 729 QDNVEGYRREITSLHE---RNQKLTATT-QKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
++ E R E R ++L +KQ Q+ Q A ++L E
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNL------LLTNLQTIQGILERSETET----- 833
++++++L+ RL QRE+ A Q+ Q L + ++ + R+E E+
Sbjct: 1753 EQQRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810
Query: 834 --KQRLSSQ---IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---------- 878
KQRL ++ +L E + L+ E QR + Q + +R
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 879 ---QLDTETNLHLNTKEL----LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
+L TE + L KE L+ ++ A ++ L Q + +R + + ++
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 932 ED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV----TSLEESLNKEK 980
+ V+D + Q RQ EE++ LK + + + + + + ++ E++L ++
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 981 QVTEEV-------------RKNIEVRLKES--AEFQTQLEKK--LMEVEKEKQELQDDKR 1023
Q E R+ E R+++S AE + ++K L EVE+ K ++++ +R
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
Query: 1024 ---RAIESMEQQL------------SELKKTLSSVQN---EVQEALQRASTALSNEQQAR 1065
RA + +QL +E K +VQ E+Q+ LQ+ + L +
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 1066 RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ A+ A EA+ + ERE VE + K+ + A R + +K L
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK-----L 2165
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
+A E R ++ + + D E + H + + + + A V++ + L +
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELT-TLRLQ 2221
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAE 1245
L E + + E L+ R + E E + +QVE + RV++ EL +L+ + AE
Sbjct: 2222 LEETDHQKNLLDEELQ--RLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAE 2277
Query: 1246 REKVQVTAKTMAQHEELMKKTETMNVVMETNKML---REEKERL----EQDLQQMQAKVR 1298
+ + K Q L ++ E M V E L +E RL E+DL Q +A
Sbjct: 2278 NRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K+ + + + L ++ +LQ +K+L +E +R + ++ ++QQ +T+ +++ L
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTL 2395
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLD 1418
E +R +++ E RLK +A + + +ED + R + E I + L
Sbjct: 2396 ---EAERQRQLEMSAEAERLKLRVAEMSRAQAR-------AEEDAQRFRKQAEEIGEKLH 2445
Query: 1419 AKIIDIQEKVKTITQVKKIGR--------RYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
+ QEKV T+ Q +I R R + EL+ +++K ++ A+ E+
Sbjct: 2446 RTELATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEM 2503
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
+VQ+ Q L+ET + +S S+ ++L + E E L++ ++ +LR+
Sbjct: 2504 QTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ Q + Q EQ RQ++ E+ R+ A+ + +++L + ++ +Q+ L +
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR---KQEELQQLEQQRRQQEELLAE 2616
Query: 1591 QKDELDVRITALKSQYEGRISRLE 1614
+ L ++ L+ Q+ ++ E
Sbjct: 2617 ENQRLREQLQLLEEQHRAALAHSE 2640
Score = 132 bits (333), Expect = 3e-30
Identities = 225/1134 (19%), Positives = 464/1134 (40%), Gaps = 126/1134 (11%)
Query: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE---KRLSHSQERLVNETREC 75
+ VQ LE ++E+ + + + E+ E +L ER + E
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 76 QSLRLELEKLNN--QLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRT 130
+ R E E+ QLKA L + + E+AQ +++A Q++ + KEE E E R +
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA-QAEAEKQKEEAEREARRRGKA 1706
Query: 131 NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
E+ ++ E ++++ K+ +G Q +L Q + ++ ++ EQ+++LL
Sbjct: 1707 EEQAVRQRELAEQELE------KQRQLAEGTAQQRLAAEQEL-IRLRAETEQGEQQRQLL 1759
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK--EEVSRLEEQMNGLKTSNE 248
+ L E T + L E E++ L +K EE SR + + + E
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 249 -----HLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
L + L +EAK Q Q + E+ A L+ + A E
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA--------EKLAAIGE 1871
Query: 303 LTRAVEELHKLLKEAGEANKAI----QDHLLE---VEQSKDQMEKEMLEKIGRLEK---- 351
TR E LKE N+ + +D + +E+ Q + ++ E++ +L K
Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
ELE L+ T R+ + EE LA + A A G EL + + + L
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELELGRIRSNAEDTL 1986
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQ---AMKEIQRL 468
E + E ++ + A +R+RE ER QK++A+ Q A++E++RL
Sbjct: 1987 RSKEQAEL-----EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+ ++A + E+++ R L+Q+ ++ EE ++ +E
Sbjct: 2042 KAKVEEARRLRERAEQESARQ----LQLAQEAAQKRLQAEEKAHAFAVQQKE-------- 2089
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESA-- 586
+ +++ QQ Q +L LR E R +E +++ + +S
Sbjct: 2090 ------------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 587 LTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPS 646
+ E E+L++S + Q Q +Q A L + + + + ++ +
Sbjct: 2138 VEEAERLKQSAEEQAQA--------------RAQAQAAAEKLRKEAEQEAARRAQAEQAA 2183
Query: 647 TSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Q + A + + + + + KA ++Q +E + + +E+L++L+ +
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
T+ Q +++ +L + E L E +L R++ T ++E
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE------A 2297
Query: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQR---ESLLAEQRGQNLLLTNLQT 821
+ ++ E+ A V A+ + ++ L+E L+QQR E +L E+ T L+
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2354
Query: 822 IQGILERSET---ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR 878
+L++ + E +RL E++ +++ + + +E + + K
Sbjct: 2355 EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL 2414
Query: 879 QLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
++ + +E + +K+ + + L E+ A+Q + ++ D
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEKVTLVQTLEIQRQQSDHDA 2472
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+LR+ ++ KE+L+ ++ + + M T +E L +E Q ++ + + L +
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 998 AEFQTQLEKKLMEVEKEK----QELQDDKRRAIESMEQQLSELKKTLSSV---QNEVQEA 1050
F Q + KL ++ +++ Q+L+++++R + MEQ+ L ++ Q+E +E
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
++R L +Q RR +Q ++ E + +L L A A E+V+
Sbjct: 2593 VRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643
Score = 114 bits (284), Expect = 1e-24
Identities = 229/1154 (19%), Positives = 445/1154 (38%), Gaps = 116/1154 (10%)
Query: 781 AENLKKEKEML--KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK--QR 836
A L+ E E+ KL +VR L + + +L++ Q + +L E + K Q
Sbjct: 1087 APTLRSELELTLGKLEQVR--SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
Query: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896
+ + + +LE + LKK L + E + L +L + + H ++
Sbjct: 1145 VPATLPELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203
Query: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLK 956
++ +A L + V +Q+ R + +++ L QLR E + L L+
Sbjct: 1204 WRERVAQLLERWQ----AVLAQTDVR--------QRELEQLGRQLRYYRESADPLGAWLQ 1251
Query: 957 TSTSNVEQYQAMVTS----LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVE 1012
+ EQ QAM + + E L +E+ + EE+ ++ E +++E F Q
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYIN------ 1304
Query: 1013 KEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA-LQRASTALSNEQQARRDCQEQ 1071
AI+ E QL K L V + ++ +Q S ++ E R +
Sbjct: 1305 ------------AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352
Query: 1072 AKIAVEAQNKYERELMLHAADVEAL--QAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
K+ E + + E L Q E+ ++A V LE+ Q AE+ + KA
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA-QAKA 1411
Query: 1130 SWEERERMLKDEVSKCVCRCE----DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVS 1185
E + L+ + + V R E D ++Q R + +++++L A ++ +
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-----Q 1466
Query: 1186 LSEEGKSQEQILEILRFIRREKEIAE--------------TRFEVAQVESLRYRQRVELL 1231
+S+ +I E +R +R + E E R E A+ + + ++ E L
Sbjct: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
R++Q+ +S + +V++ ++ A+ E +K + + E E + RL Q
Sbjct: 1527 RRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584
Query: 1290 --LQQMQAKVRKLELDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
+Q+Q + + LQ A +EK+ L E+ L EE V + R + Q
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQ 1642
Query: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
+ + E R+ E E +R Q E RL+ + A Q + + + K
Sbjct: 1643 QQAEAERARE---EAERELERWQLKANEALRLRLQ-----AEEVAQQKSLAQAEAEKQKE 1694
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
E+E ++ + Q ++ K+ T + L A+Q+ + + G+
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQV-------ENLQKTLSEKETEARNLQEQTV 1519
Q Q + +E+ L+ A K + LE+++ E L + + E E+R+ E++
Sbjct: 1755 QRQLLE-EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 1520 Q-LQSELSRLRQDLQD----RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL 1574
Q L++E R R+ ++ R EE RQ+ +E+ R+ A + LA +
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG--- 1870
Query: 1575 TKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEP 1634
E LK ++K+ + R+ L + RLE + +H+ E+ + ++
Sbjct: 1871 --EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 1635 SNKVPEQQRQI---TLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKS 1691
S+ E+Q+ + TL+ E +A + A + ++ + A +S
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 1692 TPRASI---RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSV 1748
+A + R A V + E + A Q + +E V +
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 1749 RSTSPNVQPSISQPILTVQQ------QTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQ 1802
R + ++ + Q+ Q + A QQ +++ Q+ S + ++
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108
Query: 1803 SSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV 1862
+ R + A V A ++ +R EE E A +Q +KL+
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 1863 TPVGTEEEVMAEES 1876
AE++
Sbjct: 2169 AEQEAARRAQAEQA 2182
Score = 110 bits (276), Expect = 1e-23
Identities = 195/1002 (19%), Positives = 405/1002 (40%), Gaps = 128/1002 (12%)
Query: 743 HERNQKLTATTQKQEQIINTMTQDLR-GANEKLAVAEVRAE-NLKKEKEMLKLSEVRLSQ 800
++ Q+ + Q Q + T+ L LA +R + L + + ++ +
Sbjct: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948
Query: 801 QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVE 860
QR++L + + L + Q G ++ S H L + LE +
Sbjct: 949 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS----CSHHYQQLLQSLEQGAQ 1004
Query: 861 QRHTLTRNLDVQLLDTKRQLDT-ETN-LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+ R + +L D + QL+ ET +H L K +E A Q ++ E Q A
Sbjct: 1005 EESRCQRCIS-ELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRIA--EQQKAQA 1058
Query: 919 SSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN- 977
+ GKG + + +++ L + L+ L+ + +EQ +++ E L
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT 1117
Query: 978 -----KEKQVTEEVRKNIEVRLKESAEFQTQLEK--------KLMEVEKEKQE-----LQ 1019
+ Q EEV + E +LKE+ L + K + + E Q+ L+
Sbjct: 1118 ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALR 1177
Query: 1020 DDKRRAIE---SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK--- 1073
D+ R A E ++Q+ E + + V + L+R L+ +R+ ++ +
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237
Query: 1074 --------IAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLL 1125
+ Q+ R+ + A + QA +EQ+ + ++ + +E +K E
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE---- 1293
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSDKVVASVKEGVQGPLNV 1184
EC+ ++ +KD + V LE + +++ S+ V+ + L
Sbjct: 1294 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD-----LRT 1348
Query: 1185 SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244
SE Q + K I+ET + + E L +QR E ER L E++ +L
Sbjct: 1349 HYSELTTLTSQYI---------KFISETLRRMEEEERLAEQQRAEERER-LAEVEAALEK 1398
Query: 1245 EREKVQVTAKTMAQ------------HEELMKKTETMNVVMETNKMLREEKERLEQDLQ- 1291
+R+ + A+ AQ EE++++ E + + ++EE ++L Q +
Sbjct: 1399 QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1458
Query: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL---LEEDVKRWKARNQHLVSQQKD 1348
++QAK R+ E E+ L+A ++ E +++ +AR + +Q++
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
E R ++ ++ Q E R+KAE + Q +Q+L+E +R
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR----EKQRALQALEE----LRL 1570
Query: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
+ E ++ L ++ +V+ + + ++ EL++++ E +AQ QE
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQ-----RSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS-- 1526
+HV+V +++E E Q + +++ + E + K EA L+ Q ++ + S
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 1527 ---------------RLRQDLQDRTTQEEQLRQQITEKE----EKTRKAIVAAKSKIAHL 1567
R R +++ ++ +L +Q EK+ E T + +AA+ ++ L
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745
Query: 1568 AGVKDQ-------LTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI---SRLEREL 1617
+Q L +E L++ A Q++ EL+ + ++++ E + +R E E
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
R E+ ++ + ++ E+ ++ A +R +A
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Score = 89.0 bits (219), Expect = 5e-17
Identities = 128/586 (21%), Positives = 242/586 (41%), Gaps = 102/586 (17%)
Query: 22 QNKLEKFLADQQSEIDGLKGRHEKFK---VESEQQYFEIEKRLSHSQERLVNETRECQSL 78
+ +L++ L +QS +D L+G E + E+E+ + E+ + S+ R V E +
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-RQVEEAERLKQS 2147
Query: 79 RLELEKLNNQLKALTEK-NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQE 137
E + Q +A EK KE E R + R K+ +AE + E+ ++
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 138 LEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE----------- 186
+ +++ L +L+E++ K L +L L+A + ++E+E
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2267
Query: 187 ---KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE----- 238
K + ++N L K T L EK ++ E L +E +RL +
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327
Query: 239 --------------------QMNGLKTSNEHLQKHVE---DLLTKLKEAKEQQA------ 269
+ LK E LQ+ E + +L+E KEQ A
Sbjct: 2328 LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 270 ------SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK- 322
++E + +L + L A+ S A++ RA E+ + K+A E +
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----RAEEDAQRFRKQAEEIGEK 2443
Query: 323 ------AIQDHL-----LEVEQSKDQMEKEML-EKIGRLEKELENAND---LLSATKRKG 367
A Q+ + LE+++ + + E L E I LE+E E LL +
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
+ +E+L + T A L +++ +D LL + ++ L+++
Sbjct: 2504 QTVQQEQL--LQETQA--------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKA--NKQSSV--LE 483
++ AKA L REE +R Q+ + +L +M+E +R Q + ++ KQ + LE
Sbjct: 2548 QDEVAKAQQL---REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
Query: 484 RDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
+ R+ E + + +Q++R L LEE + EEV+++ ++++
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Score = 68.9 bits (167), Expect = 5e-11
Identities = 91/417 (21%), Positives = 183/417 (43%), Gaps = 53/417 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFK-------VESEQQYFEIE---- 58
E TE + V+ +L Q E+ LK R E ++ Q++ + E
Sbjct: 2242 EATEAARQRSQVEEELFSVRV-QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK---NKELEIAQDRNIAIQSQFTR 115
K+++ RL +E LR E+ Q +AL EK K + + + +++ +
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2360
Query: 116 TKEELEAEK-RDLIRTNERLSQELEYLTEDVKRLNEKLK----ESNTTKGELQLKLDEL- 169
++EL E+ R L E+++Q+L T+ +R E + E + L+L++ E+
Sbjct: 2361 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420
Query: 170 ----QASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKC 224
+A + + ++R K+ E+ E LH T L T+ K + L + R++ + E L+
Sbjct: 2421 RAQARAEEDAQRFR-KQAEEIGEKLH--RTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQ-------------------KHVEDLLTKLKEAK 265
+ + E +L+++ L+ +E +Q + LL + + +
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQ 325
+++A +E+ F +E+ +L + E + L ++EE + EA E + Q
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597
Query: 326 DHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTA 382
+ L ++EQ + Q E+ + E+ RL ++L+ L + + A+ EE+ A A
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQ-----LLEEQHRAALAHSEEVTASQVAA 2649
Score = 39.7 bits (91), Expect = 0.035
Identities = 157/745 (21%), Positives = 291/745 (39%), Gaps = 114/745 (15%)
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q +++N D+ N KL + + L ++S++++S Q E + A+++ L
Sbjct: 140 RQVKLVNIRNDDIADGNPKLTLGLIWTIILH-----FQISDIQVSGQSEDMTAKEK---L 191
Query: 815 LLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQ--RHTLTRNLDV 871
LL + + ++G R + T S + +L + I H K L ++ + R T NLD
Sbjct: 192 LLWSQRMVEGYQGLRCDNFTS---SWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 248
Query: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS-QSSQRTGKGQPSN 930
+R L L ++ + +K I T L + +V Q R + Q
Sbjct: 249 AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRW 308
Query: 931 KEDVDDLVSQLRQTEEQVNDLKER-LKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN 989
+E + ++ L+ +ER +S +E + +E K+ + K
Sbjct: 309 QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 368
Query: 990 IEVRLK---ESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
I L+ ++ + + ++VEKE +L AI E+QL + E
Sbjct: 369 IYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV----AILEREKQLRS--------EFE 416
Query: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKM 1106
E LQR T L E C+EQ A L +DV L A K V +
Sbjct: 417 RLECLQRIVTKLQMEAGL---CEEQLNQADA----------LLQSDVRLLAAGK--VPQR 461
Query: 1107 ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKL 1166
A +E KA+S + R+L ++V + Q ++ ++ +L
Sbjct: 462 AG---EVERDLDKADSMI-----------RLLFNDVQTLK---DGRHPQGEQMYRRVYRL 504
Query: 1167 SDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQ 1226
+++VA ++ N +R + +A +VAQV ++
Sbjct: 505 HERLVA-----IRTEYN-------------------LRLKAGVAAPATQVAQVTLQSVQR 540
Query: 1227 RVELLERELQELQDSLN-AEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
R EL + L+ LQD L E + +V A+ + + + + ++ + R + E
Sbjct: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600
Query: 1285 RLEQDLQQMQAKVRKLELDI---LPLQEANAELSEK----------SGMLQAEKKLL--- 1328
R D Q+ R D L LQ A S K S + A K+L+
Sbjct: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660
Query: 1329 ---EEDVK-RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
EE+V W RN ++ +++ E Y L+ E E+ K+I++L RL E
Sbjct: 661 EKEEEEVGFDWSDRNTNMTAKK-----ESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
Query: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQ 1444
+ ++ + Q +Q+ + ++ E K+ A + + Q++K+ + +
Sbjct: 716 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK 775
Query: 1445 YEELKAQQDKVMETSAQSSGDHQEQ 1469
Y ++ +E Q + D +EQ
Sbjct: 776 YSCDRSATVTRLEDLLQDAQDEKEQ 800
Score = 32.0 bits (71), Expect = 7.4
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 1/97 (1%)
Query: 1975 DEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGEGNHRAA-D 2033
D D M +EG +A GY + + G G+ G+ T G G+ R + D
Sbjct: 4475 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
Query: 2034 SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRA 2070
+ SG T ++ S S R S++ P +
Sbjct: 4535 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPES 4571
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 202 bits (515), Expect = 2e-51
Identities = 344/1655 (20%), Positives = 718/1655 (43%), Gaps = 261/1655 (15%)
Query: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTE--KNKELEIAQD 104
KVES ++ ++E ++ ++L + + LR E E+LN + + + E +N +LE ++
Sbjct: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
Query: 105 RNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQL 164
+ A++ T T++E + + RL Q L ++ RL+ ++++ + L+L
Sbjct: 361 QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420
Query: 165 KLDELQASDVSVKYREKR-LEQEKELLHSQNTWLNTE---LKTKTDELLALGREKGNEIL 220
K+ + V +EK L QEKE L LN E +K+ ++L +E+
Sbjct: 421 KM------RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL----DSELH 470
Query: 221 ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
+L+ NLE K E+++N + E L +E+L + +EA + ++++ + N
Sbjct: 471 DLRLNLEAK-------EQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN 523
Query: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
+ + K +D + + ++L ++ K L E K IQ EV + + K
Sbjct: 524 EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE--KLIQS---EVALNDLHLTK 578
Query: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
+ +LE ++EN D L+ ++ + +E L +K ++ E
Sbjct: 579 Q------KLEDKVENLVDQLNKSQESNVSIQKENLE------------LKEHIRQNEEEL 620
Query: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAV--ASLSVKL 458
+ + + L++ L + + D ++KE EA+ LK+ E E+ + + + VK+
Sbjct: 621 SRIRNE---LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677
Query: 459 EQ-----AMKEIQRLQEDTDKANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEAR 511
E A ++++ E+ N Q S LE++ ++++ ++ ++ L E
Sbjct: 678 ENEKLVLACEDVRHQLEECLAGNNQLS-LEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
Query: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
+ EE+S+A ++S + +H ++ +L Q+ + L++ E + + +ET
Sbjct: 737 NKYEKTIEELSNARNLNTSALQLEH----EHLIKLNQKKDMEIAELKKNIEQMDTDHKET 792
Query: 572 ---------TSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
++T+L K E + +L++ Q ++ +R+ ++ R + +
Sbjct: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
Query: 623 GVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFEN 681
L + ++ L +R Q S APV ++ +++ E + + QL I E+
Sbjct: 853 R---SLGSMKEENNHLQEELERLREEQ--SRTAPVADPKTLDSVTELASEVSQLNTIKEH 907
Query: 682 YKKEKAENEKIQNEQ-------LEKLQEQ---VTDLRSQNTKIS---TQLDFASKRYEM- 727
++E ++KI +Q L+ LQEQ + + R Q+ +++ TQL F K E+
Sbjct: 908 LEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL-FLEKDEEIK 966
Query: 728 -LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK- 785
LQ +E + T LHE Q + Q + ++ +EK +++ E L
Sbjct: 967 SLQKTIEQIK---TQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 786 --KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
KE+E+ E++L ++ L +Q Q L + + I+++ + E Q L ++I
Sbjct: 1024 GIKEREL----EIKLLNEKNISLTKQIDQ-LSKDEVGKLTQIIQQKDLEI-QALHARISS 1077
Query: 844 LEH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT---KELLKNAQ 898
H ++ +L+++L Q + + R +L+ K T N HL T K + A
Sbjct: 1078 TSHTQDVVYLQQQL-----QAYAMEREKVFAVLNEK----TRENSHLKTEYHKMMDIVAA 1128
Query: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER---- 954
KE A +K N ++ +SS GQ +E + +L +R+ + +++ L ++
Sbjct: 1129 KEAALIKLQDENKKLSTRFESS-----GQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183
Query: 955 ---LKTSTS-------NVEQYQAMV---TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
L+TS++ N Q++ ++ L++ + K ++ ++V ++ ESA+ Q
Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243
Query: 1002 T---QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELK---KTLSSVQNEVQEALQRAS 1055
QL+ +++ +LQ D I+S EQ ++LK + L+ VQ+ + +
Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKD 1303
Query: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
L K+ + + L L E L+A+K +V L E
Sbjct: 1304 LLL-------------GKLDIISPQLSSASL-LTPQSAECLRASKSEV---------LSE 1340
Query: 1116 TTQKAESQLLECKASWEERERMLK------DEVSKCVCRCEDLEKQNRLLHDQIEKLSDK 1169
+++ + +L E + S +E++ ++ +S + +LE++ H+Q +D
Sbjct: 1341 SSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKE---HEQ----TDS 1393
Query: 1170 VVASVKEGVQGPLNVSLSE-----EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
+ +KE Q L L E + KS + + F + E R V +
Sbjct: 1394 EIKQLKE-KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL----- 1447
Query: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
++R+ +LE ++ +L+ E EK+ T + + +++T M+ + MLR
Sbjct: 1448 KERILILEMDIGKLK----GENEKIVETYRGKETEYQALQETN-----MKFSMMLR---- 1494
Query: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
E++ + K + L + L ++ + E + +L A K + E+ V + R+Q +++
Sbjct: 1495 --EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552
Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
L +K++ +Q E+ RL+ + RSN L +N + ++
Sbjct: 1553 -------------LKQKQMENTALQ---NEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
Query: 1405 KVRTEKETIQKDLDAKIIDIQEK-VKTITQVKKIGRRYKTQYEELKAQQDKVM----ETS 1459
+ E + L K+ ++EK V + ++ + Q E L+ Q + V ET+
Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
Query: 1460 AQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES-QVENLQKTLSEKETEARNLQEQT 1518
Q S ++ + L+ L + + K++ S ++E ++ ++E + A NL+ +
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKV 1716
Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
+ LQ L L + +L +Q+ KEE+
Sbjct: 1717 ISLQECLDEANAALDSAS----RLTEQLDVKEEQI------------------------- 1747
Query: 1579 EELKQRNGALDQQKDELDVRITALKSQYEGRISRL 1613
EELK++N + D++ ++ +L + EG++ ++
Sbjct: 1748 EELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
Score = 172 bits (436), Expect = 4e-42
Identities = 344/1695 (20%), Positives = 689/1695 (40%), Gaps = 300/1695 (17%)
Query: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
EE+EAE D ++E+E + ++ NE+LK+ T E + E+Q S
Sbjct: 43 EEVEAELPD------SRTKEIEAIHAILRSENERLKKLCTDLEEKH-EASEIQIKQQSTS 95
Query: 178 YREKRLEQEKELLH--SQNTWLNTEL-----------------KTKTDELLALGREKG-- 216
YR + ++E E+ H ++ L +L T A G
Sbjct: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
Query: 217 ---------NEILELKCNLENKKEEVSRLEEQMN------------GLKTSNEHLQKHVE 255
+I+ + + EVSRLE ++ G S++ ++
Sbjct: 156 AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215
Query: 256 DLLTKLKEAKEQQASMEEKFHNEL-NAH----IKLSNLYKSAADDSEAKSNELTRAVEEL 310
+++ +LK+ + Q+ + + L NAH ++S ++ D E + +EEL
Sbjct: 216 NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEER-------IEEL 268
Query: 311 HKLLKEAGEANKAIQDHLLEVEQSKD-----QMEK-EMLEKIGRLEKELENANDLLSATK 364
LL++ G I+ L ++ + + Q+EK E +K+ +LE ++++ N LS+ +
Sbjct: 269 ENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAE 326
Query: 365 RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI--NKY 422
IL E+ + + + ++E+ EN ++ +K
Sbjct: 327 NDRDILRREQ--------------------------EQLNVEKRQIMEECENLKLECSKL 360
Query: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
VK+ + +E AQ A +L+QA+ + + N+ +S+
Sbjct: 361 QPSAVKQSDTMT------EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLA 414
Query: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEE------VSSADISSSSEVISQH 536
E DN +++++++ L ++ +L E EE + + + + E ++ DIS SE+
Sbjct: 415 E-DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 537 LVSYRNIEELQQ---QNQRLLVALRELGETREREEQETTS------SKITELQLKLESAL 587
L +EL Q + + L+ + EL +R+ QE T ++++ Q + +S +
Sbjct: 474 LNLEAKEQELNQSISEKETLIAEIEEL----DRQNQEATKHMILIKDQLSKQQNEGDSII 529
Query: 588 TELEQ-LRKSRQHQMQLVDS---IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
++L+Q L ++ QL D I ++ D+ + L Q+ LH
Sbjct: 530 SKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL------------- 576
Query: 644 RPSTSQTVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQE 702
T Q + V + ++ E+ ++ K+ E+ E+ ++ + E +I+NE ++ L +
Sbjct: 577 ---TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
Query: 703 QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762
+ N K D K E N++ E+ L+E +K+ + + + +
Sbjct: 634 D----SNSNFK-----DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684
Query: 763 MTQDLR--------GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+D+R G N+ E LK EK + E L ++ LL E
Sbjct: 685 ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI---EAELCWAKKRLLEEANKYEK 741
Query: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
+ L + + + + L +K + EI+ LKK +E +++ H T+++ L
Sbjct: 742 TIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSL 800
Query: 875 DTKRQLDTETNLHL----NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSN 930
+ ++QL N KE Q+E+ Q L E+ Q+ + + S
Sbjct: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGSM 858
Query: 931 KEDVDDLVSQLRQTEEQ------VNDLK--ERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
KE+ + L +L + E+ V D K + + S V Q + LEE + +++
Sbjct: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918
Query: 983 TEE-------VRKNIEVRLKESAEFQTQLEKKLM---EVEKEKQELQDDKRRAIESMEQQ 1032
E+ + ++++ + KE EF+ Q E+ ++ EK E ++ IE ++ Q
Sbjct: 919 IEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ 978
Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL-MLHAA 1091
L E ++ + + +++ + + S + N + + + + V+ + E E+ +L+
Sbjct: 979 LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038
Query: 1092 DVEAL----QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE-----ERERMLKDEV 1142
++ Q +K++V K+ + Q + Q +++ + + ++ + E
Sbjct: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER 1098
Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL---NVSLSEEGKSQEQ---- 1195
K + ++N L + K+ D V A KE L N LS +S Q
Sbjct: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAA--KEAALIKLQDENKKLSTRFESSGQDMFR 1156
Query: 1196 -ILEILRFIRREKEI--------AETRFEVAQVES-------LRYRQRVELLER--ELQE 1237
++ L I REK+I +T V Q S + Q ELL+ +L++
Sbjct: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216
Query: 1238 LQDSLNAEREKVQVTAKTMAQHE------ELMKKTETMNVVMETNKMLREEKERLEQDLQ 1291
+ +++V T + M QHE EL + + V + N L+ + L Q +
Sbjct: 1217 QVKKMEEWKQQVMTTVQNM-QHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYE 1275
Query: 1292 QMQAKVRKLELDILPLQEANAELSEK-----------SGMLQAEKKLLEEDVKRWKARNQ 1340
Q + K++ ++ +Q + +L S L + L + + +A
Sbjct: 1276 QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKS 1335
Query: 1341 HLVSQQKD---PDTEEYRKLLSEKEVHTKRIQQLTEEIG---RLKAEIARSNASLTNNQN 1394
++S+ + + EE RK L EK+ + +Q+ + +E+ R T+++
Sbjct: 1336 EVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE- 1394
Query: 1395 LIQSLKED---LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE---- 1447
I+ LKE L K+ EK+ + K +++ E ++ R+ T +E
Sbjct: 1395 -IKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453
Query: 1448 -------LKAQQDKVMETSAQSSGDHQ--------------EQHVSVQEMQE-------- 1478
LK + +K++ET ++Q E+ M+E
Sbjct: 1454 LEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQL 1513
Query: 1479 LKET-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQD 1531
LKE LNQ KS++ + Q+ + + Q + LQ+E+ RLR D
Sbjct: 1514 LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR-D 1572
Query: 1532 LQDRTTQE-EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+ R+ QE E+LR + E E+ + +AA+ + A L + ++T E+L + A++
Sbjct: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL---RKKVTVLEEKLVSSSNAMEN 1629
Query: 1591 QKDELDVRITALKSQ 1605
+ V++ +L+ Q
Sbjct: 1630 ASHQASVQVESLQEQ 1644
Score = 138 bits (347), Expect = 7e-32
Identities = 193/1002 (19%), Positives = 416/1002 (41%), Gaps = 115/1002 (11%)
Query: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
+ +L+ E ++ T L E+++ ++Q Q +++ ++ ++A +
Sbjct: 61 HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ-----KEVEISHLKARQI 115
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ--IE 842
+ ++LKL S + + + + + + +SSQ I
Sbjct: 116 ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175
Query: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
+L +E+S +LE+EV + + Q D Q + L KEL +N +EI
Sbjct: 176 RLSNEVS----RLESEVGHWRHIAQTSKAQGTDNSDQSEI-CKLQNIIKELKQNRSQEID 230
Query: 903 TLKQHLS---NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQ-----TEEQVNDLKER 954
+ +S N Q ++ S+R + +E +++L + L+Q E ++ + E
Sbjct: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
Query: 955 LKT----------STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQL 1004
KT ST +EQ + + + + L+ + + +R+ E E + +
Sbjct: 291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEEC 350
Query: 1005 EKKLMEVEK------EKQELQDDKRRAI--ESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
E +E K ++ + +K R + + +++ L++ LS +NE+
Sbjct: 351 ENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMR------- 403
Query: 1057 ALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEET 1116
LS+ Q ++ K+ + + E+E L + + E LQ + +++ V +
Sbjct: 404 -LSSLNQDNSLAEDNLKLKMRIE-VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATR 461
Query: 1117 TQKAESQLLECKASWEERERMLKDEVSK---CVCRCEDLEKQNRLLHDQIEKLSDKVVAS 1173
+S+L + + + E +E+ L +S+ + E+L++QN+ + + D++
Sbjct: 462 DISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521
Query: 1174 VKEG--VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL 1231
EG + L L++E K Q+ + I +E ++ + + ++V + L
Sbjct: 522 QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
Query: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
E +++ L D LN +E + Q E L K E +++ E + L QD
Sbjct: 582 EDKVENLVDQLNKSQE-----SNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN 636
Query: 1290 -------LQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL 1342
L++ +A+VR L+ ++ L++ N L K + DVK N+ L
Sbjct: 637 SNFKDTLLKEREAEVRNLKQNLSELEQLNENL-----------KKVAFDVKM---ENEKL 682
Query: 1343 VSQQKDPDTEEYRKLLSEKEVHTKR---IQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
V +D + L ++ ++ ++ L E G ++AE+ + L N +
Sbjct: 683 VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742
Query: 1400 KEDLNKVRT-EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
E+L+ R +Q + + I Q+K I ++KK + T ++E K +E
Sbjct: 743 IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE 802
Query: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Q + ++ + +++++E L + K + E L++T+ EK+ +++E+
Sbjct: 803 QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKE- 1577
LQ EL RLR++ Q RT + KT ++ S+++ L +K+ L +E
Sbjct: 863 NHLQEELERLREE-QSRTA---------PVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
Query: 1578 ----------NEELKQRNGALDQQKDELD----------VRITALKSQYEGRISRLEREL 1617
N+ Q +L +QK E+D T L + + I L++ +
Sbjct: 913 KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI 972
Query: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
+ + + E+R + Q ++ + ++ + +L S + ++
Sbjct: 973 EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 1014
Score = 100 bits (250), Expect = 1e-20
Identities = 189/952 (19%), Positives = 406/952 (42%), Gaps = 120/952 (12%)
Query: 3 AVLQQVLERTELNKLPKSVQNKL---EKFLADQ-QSEIDGLKGRHEKFKVESEQQYFEIE 58
+V + E ++LN + + ++ ++ +K + DQ QS++ L+ E+ K E +Y +
Sbjct: 890 SVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQ 949
Query: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
+H+Q + + E +SL+ +E++ QL E+ ++++ + +I +++
Sbjct: 950 MNATHTQ-LFLEKDEEIKSLQKTIEQIKTQLH---EERQDIQ-TDNSDIFQETKVQSLNI 1004
Query: 119 ELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE-------LQ 170
E +EK DL + ERL + ++ ++K LNEK + TK QL DE +Q
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEK--NISLTKQIDQLSKDEVGKLTQIIQ 1062
Query: 171 ASDVSVKYREKRLEQEKELLHSQNT-WLNTELKT---KTDELLALGREKGNEILELKCNL 226
D+ ++ R+ H+Q+ +L +L+ + +++ A+ EK E LK
Sbjct: 1063 QKDLEIQALHARISSTS---HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL-----------LTKLKEAKEQQASMEEKF 275
+ V+ E + L+ N+ L E L+++ K+ + +
Sbjct: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179
Query: 276 HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK 335
L A ++ S+ A + + EL + ++L + +K+ E + + + ++
Sbjct: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
Query: 336 DQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
Q+++E+ + ++ + +N + L G I S E+ K+ G +L
Sbjct: 1240 AQLQEELHQLQAQVLVDSDNNSKL--QVDYTGLIQSYEQNET---------KLKNFGQEL 1288
Query: 396 TELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
++ ++ + T+D LLL KL+ I+ + A +L Q E RA K+
Sbjct: 1289 AQVQHSIGQLCNTKD-LLLGKLD----------IISPQLSSASLLTPQSAECLRASKSEV 1337
Query: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
LS E +E++ L++ + + L+ +N R+ + S ELE R
Sbjct: 1338 -LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS--------ELE--RK 1386
Query: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETT 572
H D E+ + + Q L+ +++ ++ ++ +LL + T + E E
Sbjct: 1387 EHEQTDSEIKQL---KEKQDVLQKLLKEKDLL-IKAKSDQLLSSNENF--TNKVNENELL 1440
Query: 573 SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
+T L+ ++ ++ +L+ + ++V++ + Y+ L ++ L
Sbjct: 1441 RQAVTNLKERILILEMDIGKLKGENE---KIVETYRGKETEYQALQETNMKFSMMLREKE 1497
Query: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKI 692
+ S+ K + Q + E + + A ++++ +F+ + + K
Sbjct: 1498 FECHSMKE--KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQ 1555
Query: 693 QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTAT 752
+ + LQ +V LR + + + +L+ + L ++ + Y RE + +R KL
Sbjct: 1556 KQMENTALQNEVQRLRDKEFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKK 1612
Query: 753 TQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ 812
E+ + + + + A+ + A V+ E+L+++ ++ + Q S+ EQ Q
Sbjct: 1613 VTVLEEKLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQL-SVSQEQVKQ 1668
Query: 813 NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLEN--------------- 857
L +L +Q +LE + E K S+++EK + I+ KK EN
Sbjct: 1669 YAL--SLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA 1726
Query: 858 --EVEQRHTLTRNLDV---QLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
++ LT LDV Q+ + KRQ + +E+L + QK++ +L
Sbjct: 1727 NAALDSASRLTEQLDVKEEQIEELKRQNELR-------QEMLDDVQKKLMSL 1771
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 202 bits (514), Expect = 3e-51
Identities = 377/1878 (20%), Positives = 782/1878 (41%), Gaps = 276/1878 (14%)
Query: 9 LERTELNKLPKSVQNKLEKFLADQQS--------------EIDGLKGRHEKFKVESEQQY 54
L + E+N+L Q + QS E++ KF+ + + +
Sbjct: 32 LSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKV 91
Query: 55 FEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT 114
++E L +Q+ R+ + LR E+ +L QL+ + +++E ++ + Q
Sbjct: 92 MKLENELEMAQQSAGG--RDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLA 149
Query: 115 RTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
EE E E L R N+RL ++ E L +D+ +++ T L + SD
Sbjct: 150 LRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKET-----LLSRRGEDSDY 204
Query: 175 SVKYREKRLEQEKELLHSQN-TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEV 233
+ +K E + L Q T N +++ + E+ E E+ ++ K V
Sbjct: 205 RSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIV 264
Query: 234 SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAA 293
+ + ++ LK N+H Q V++L LK E+ ++ +NA ++ L S+
Sbjct: 265 HQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE----DDPIMVAVNAKVEEWKLILSSK 320
Query: 294 DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
DD + ++ + E KL +A+K+ L + Q +D K + E++ + KE+
Sbjct: 321 DDEIIEYQQMLHNLRE--KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEM 378
Query: 354 ENANDLLSATK-----RKGA-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
E ++ K KGA LS++ + T + + K + EL A +D
Sbjct: 379 EKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKD 438
Query: 408 QLLLEKLENKRINKY------LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
+ L+E L KR+ Y L++ V E++ +K + E E K + L +K+
Sbjct: 439 KELVEAL--KRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDF 496
Query: 462 MKEIQRLQEDTDKANK---------------------QSSVLERDNRRMEIQVKDLSQQI 500
+ E + L+E K ++ +L ++ +E + DL ++I
Sbjct: 497 LDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKI 556
Query: 501 RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH---LVSYRNIEELQQQNQRLLVAL 557
R + E + + E+++ + S + IS+ L+S +N+ E Q +N+ L
Sbjct: 557 RQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFL---S 613
Query: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
REL E + + E + + I + Q KL+ + E +QL + + +Q + + + D +
Sbjct: 614 RELIE--KERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPD----V 667
Query: 618 LSQTTGVAIP-----------LHASSLDDVSL-------ASTPKRPSTSQTVSTPAPVPV 659
T + IP +A + D SL T + Q + +
Sbjct: 668 KGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 727
Query: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK--LQEQVTDLRSQN---TKI 714
S + +A + L++ ++ + N + L + + SQN +
Sbjct: 728 NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 787
Query: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKL 774
+L+ K+ + L+D++E Y R+ + + L +++ T ++ ++ KL
Sbjct: 788 LQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKL 847
Query: 775 AVAEVRAENLKKEKEMLKLSEVRL-SQQRESLLAEQRGQNLLLTNLQTIQGILERSET-- 831
+V+ + +K ++ L+ +++ S + + +LAE + +T LQ + L R T
Sbjct: 848 E-DQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRK---ITVLQVNEKSLIRQYTTL 903
Query: 832 -ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD-TKRQLDTETNLHLN 889
E +++L + EK ++E+ ++ ++ E+ L R ++ + Q + ++ L+
Sbjct: 904 VELERQLRKENEKQKNELLSMEAEV---CEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS 960
Query: 890 TKELLKNAQKEIATLKQHL---SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
EL E+ + + NM VQ S + + S KE V+ + +L T+E
Sbjct: 961 ELELANKQYNELTAKYRDILQKDNMLVQRTS-NLEHLECENISLKEQVESINKELEITKE 1019
Query: 947 QVNDLKERLKTST-----------------SNVEQYQAMVTSLEESLNKEKQVTEEVRK- 988
+++ +++ + T S++ +T LE E+Q E +K
Sbjct: 1020 KLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKM 1079
Query: 989 --NIEVRLKESAEFQTQLEKKLMEVEK-----------EKQELQDDKRRAIESME-QQLS 1034
++ LK+ E +LE K E+ K + EL D +A+ + Q++
Sbjct: 1080 YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL 1139
Query: 1035 ELKKTLSSVQNEVQEA-----LQRASTALSNEQQARRD--------------CQEQAKIA 1075
EL+K ++ EV + + R + N QQ RD Q K
Sbjct: 1140 ELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSL 1199
Query: 1076 VEAQNKYERELML-HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
+ +++ L L A + L++ ++ KM + LE+ + E L + R
Sbjct: 1200 IAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNR 1259
Query: 1135 ERMLK-------------------DEVSKCVCRC----------------EDLEKQNRLL 1159
+ L+ ++ SK + + E +N+ L
Sbjct: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTL 1319
Query: 1160 HDQIE-KLSDKVVASVKE--GVQGPLNVSLS-EEGKSQEQILEILRFIRREKE------- 1208
+++ K +++++++K+ G Q +N + EE + QE L++ R + ++KE
Sbjct: 1320 EMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQE--LKLNRELVKDKEEIKYLNN 1377
Query: 1209 -IAETRFEVAQVE-------------SLRYRQRVELLEREL----QELQDSLNAEREKVQ 1250
I+E ++ +E + + QR LER+L ++ + LNA ++ +
Sbjct: 1378 IISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEE 1437
Query: 1251 VTAK-------TMAQHEELMKK-TETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302
T Q E ++K E + +++ET R + LE+ L++ ++ +R E
Sbjct: 1438 ATGSIPDPSLPLPNQLEIALRKIKENIRIILET----RATCKSLEEKLKEKESALRLAEQ 1493
Query: 1303 DILPLQEANAELSEK-SGMLQAEKKLLEEDVKRWKARNQHLVS-------------QQKD 1348
+IL + EL + + EK + E K + ++ H + QK+
Sbjct: 1494 NILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKE 1553
Query: 1349 PDTEEYRKLLSEKEVHTKRIQQLTEE---IGRLKAEIARSNASLTNNQNLIQSLKEDLNK 1405
++Y++LL + + I + EE I + E+ ++ Q +K+
Sbjct: 1554 EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTP 1613
Query: 1406 VRTEKETIQ-KDLDAKIIDIQEKVKT-ITQVKKIGRRYKTQYE--ELKAQQDKVMETSAQ 1461
V T K I+ +++ + + + + + + ++KK+ + + Q E ELK ++ + ++ Q
Sbjct: 1614 VPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQ 1673
Query: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA-RNLQEQTVQ 1520
+ + + + V E+++LK L+Q++ +S+ L+S+++ ++ S T RNL E +
Sbjct: 1674 ENHEDEVKKVKA-EVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVE---R 1729
Query: 1521 LQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEE 1580
L+S+L+ + + + +LR ++T E+ + I A K AHL V+ + + E
Sbjct: 1730 LKSQLALKEKQQKALSRALLELRAEMTAAAEE--RIISATSQKEAHL-NVQQIVDRHTRE 1786
Query: 1581 LKQRNGALDQQKDELDVRITALKSQYEG---RISRLERELREHQERHLEQRDEPQEPSNK 1637
LK + L++ +L + K++ ++ L EL++ Q+ + + E +E +
Sbjct: 1787 LKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQE 1846
Query: 1638 VPEQQRQITLKTTPASGE 1655
E +RQI T+ G+
Sbjct: 1847 NDELKRQIKRLTSGLQGK 1864
Score = 173 bits (439), Expect = 2e-42
Identities = 371/1820 (20%), Positives = 741/1820 (40%), Gaps = 286/1820 (15%)
Query: 29 LADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQ 88
L + S+ D + R K + S + E + + L+ + R+ + R + K N+
Sbjct: 579 LTENISQGDRISER--KLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
Query: 89 LKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE--------- 139
LK L E+NK+LE + + + + E +I + ERL +E
Sbjct: 637 LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
Query: 140 ----------YLTEDVKRLNEKLKESNTTK-------GELQLKLDELQASDVSVKYRE-- 180
LT + L ++L+ES + LK+D L+ ++ E
Sbjct: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756
Query: 181 ----KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR- 235
K ++ + S + +N++ + L+ L +E N+ +LK NLE+ E+ +R
Sbjct: 757 NVVFKGIDLPDGIAPSSASIINSQ----NEYLIHLLQELENKEKKLK-NLEDSLEDYNRK 811
Query: 236 ----------LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNA-HIK 284
L ++ K + + K +++ KL++ +Q A ++++N LNA +
Sbjct: 812 FAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMD 871
Query: 285 LSNLYKSAADDS------EAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM 338
+ K A++S + L R L +L ++ + N+ ++ LL M
Sbjct: 872 SDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLS-------M 924
Query: 339 EKEMLEKIGRLEKELENANDLLSATKR---KGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
E E+ EKIG L++ E A ++A ++ LSE ELA K +L
Sbjct: 925 EAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELAN------------KQYNEL 972
Query: 396 TELYNAYVETQDQLL-----LEKLE--NKRINKYLDEIVKEVEAKAPILKRQREEYE--- 445
T Y ++ + L+ LE LE N + + ++ I KE+E L + +E
Sbjct: 973 TAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET 1032
Query: 446 ---------RAQKAVAS---LSVKLEQAMKEIQRLQED--TDKANKQSSVLERDNRRMEI 491
+A+K++ + +S+ + M E++ L E + K L ++ME
Sbjct: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
Query: 492 QVKDLSQQIRVLL-MELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
+ +L + L + L+ + ++RDE S + S + L +N EL+ +
Sbjct: 1093 RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEV 1152
Query: 551 QRLLVALRELGETRERE------EQETTSSKITELQLKL---ESALTELEQLRKSRQHQM 601
+L RE+ + R+ +Q++ ++ L+++L ++ E + K QH +
Sbjct: 1153 SKL----REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNV 1208
Query: 602 QL-------------VDSIVRQRDMYRILLSQTTGVAIP-LHASSLDDVSLASTPKRPST 647
L + S +++ + Y + L Q L+ + L+ + A ++
Sbjct: 1209 SLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQ 1268
Query: 648 SQTVSTPAPVPVIESTEAIEAKAALKQLQ-EIFENYKKEKAENEKIQNEQLEK------L 700
S +P+ + + + L+ + +I + K + E+ ++N+ LE L
Sbjct: 1269 SLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL 1328
Query: 701 QE-------------------QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITS 741
+E ++ +LR Q K++ +L + + L + + Y R I+S
Sbjct: 1329 EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388
Query: 742 L----------HERNQ----KLTATTQKQEQIINTMTQDLRGANEKLAVA---------- 777
L HE Q + ++Q I + ++ A +K A
Sbjct: 1389 LEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448
Query: 778 -----EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETE 832
E+ +K+ ++ + E L ++ L N+ + ++ E
Sbjct: 1449 LPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVIN----E 1504
Query: 833 TKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
+ RL + E+ E I+ L +K E E + HTL + + + + +L+ + + +
Sbjct: 1505 LRLRLPATAER-EKLIAELGRK-EMEPKSHHTL-KIAHQTIANMQARLNQKEEVLKKYQR 1561
Query: 893 LLKNAQKEIATL-KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDL 951
LL+ A++E + K+H ++ + + + + K+ DL+ Q T N
Sbjct: 1562 LLEKAREEQREIVKKHEEDLHI-LHHRLELQADSSLNKFKQTAWDLMKQ-SPTPVPTNKH 1619
Query: 952 KERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQL-EKKLME 1010
RL V + ++SL L K Q E R+ E+++KE + QL E E
Sbjct: 1620 FIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDE 1679
Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
V+K K E++D K +S ++ + L S +EA RA T R +
Sbjct: 1680 VKKVKAEVEDLKYLLDQSQKE-----SQCLKSELQAQKEANSRAPTTTMRNLVER--LKS 1732
Query: 1071 QAKIAVEAQNKYERELM-----LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ-- 1123
Q + + Q R L+ + AA E + +A Q +V+Q ++ T++ ++Q
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVE 1792
Query: 1124 --------LLECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLH--DQIEKLSDKVVA 1172
L E + + RE L D ++ + +K N++L ++I++ +D++
Sbjct: 1793 DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKR 1852
Query: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
+K G L++ Q I E+ R +++ + E + E ++ ++ + E L
Sbjct: 1853 QIKRLTSGLQGKPLTD--NKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELI 1910
Query: 1233 R--ELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDL 1290
R E ++ Q + R K++ + E+ T+ +N + + +EK L++ L
Sbjct: 1911 RWEEGKKWQAKIEGIRNKLK------EKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKL 1964
Query: 1291 --------QQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDV-------KRW 1335
Q + + + E ++ L++ N +L ++A + L + V R+
Sbjct: 1965 KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY 2024
Query: 1336 KARNQHLVSQQKDPDTEEYRKLLS-EKEVHTKRIQQLTEEIGRLKAE-------IARSNA 1387
H + +Q DT + E + H +R Q+L +E +L +E + ++N
Sbjct: 2025 LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANK 2084
Query: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDL------DAKIIDIQEKVKTITQVKKIGRRY 1441
L +N ++ LKE ++ EK +Q+ L I E KTI +KK+ +
Sbjct: 2085 DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKV 2144
Query: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA-----ETKSKSLE-- 1494
+ + E+LK + TS + + QE E+++LK L E+K+K E
Sbjct: 2145 QRENEQLKKASG--ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202
Query: 1495 -SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD---RTTQEEQLRQQITEKE 1550
++ E L+K L ++ A L+ L+ ++ L++ R E Q+ +
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262
Query: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENE----------ELKQRNGALDQQKDELDVRIT 1600
K+ K+IV + L ++ + K+N+ E +R +++ ++L+ +I
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK 2322
Query: 1601 ALKSQYEGRISR--LERELR 1618
LK EG + L+REL+
Sbjct: 2323 ILKHVPEGAETEQGLKRELQ 2342
Score = 171 bits (432), Expect = 1e-41
Identities = 327/1604 (20%), Positives = 662/1604 (41%), Gaps = 223/1604 (13%)
Query: 49 ESEQQYFEIEKRLSHSQERLVN-ETRECQ--SLRLELEKLNNQLKALTEKNKELEIAQDR 105
E +Y +I ++ + +R N E EC+ SL+ ++E +N +L+ EK +E A ++
Sbjct: 971 ELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQ 1030
Query: 106 NIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLK 165
+ ++ + K + D++ +++++ ++K LNE+ + + K L+
Sbjct: 1031 ETKLGNESSMDKAKKSITNSDIVSISKKITML------EMKELNERQRAEHCQKMYEHLR 1084
Query: 166 LDELQASDVSVKYREKRLEQEKELLHSQNT--WLNTELKTKTDELLALGREKGNEILELK 223
Q + + + K E K L +Q L EL + A+ ILEL+
Sbjct: 1085 TSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSK--AVSDADRQRILELE 1142
Query: 224 CNLENKKEEVSRLEE-------QMNGLKTSNEHLQKHVEDLLTKLKE--AKEQQASMEEK 274
N K EVS+L E Q+ L + K VE L +L + A+ + S+ K
Sbjct: 1143 KNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK 1202
Query: 275 FHNELNAHIKLSNL--------YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
H N ++LS S EA + L + ++E + L A +
Sbjct: 1203 LHQH-NVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
Query: 327 HLLEVEQS-------------KDQMEKEMLEKIG---RLEKELENAND---------LLS 361
HL + QS +++ K M++ ++ +E++N+ L
Sbjct: 1262 HLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEM 1321
Query: 362 ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINK 421
K KG EEL + K++ MK+ EL ++ +L+ +K E K +N
Sbjct: 1322 ELKLKGL----EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNN 1377
Query: 422 YLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ--- 478
+ E + + + + +Q + +E Q A V LE+ + R Q + A ++
Sbjct: 1378 IISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEE 1437
Query: 479 --SSVLERD---NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI 533
S+ + ++EI ++ + + IR++L + E+ S+ ++ + +
Sbjct: 1438 ATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILS 1497
Query: 534 SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQ 592
+++ + + L+A ELG +E E + + KI + +++ L + E+
Sbjct: 1498 RDKVINELRLRLPATAEREKLIA--ELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554
Query: 593 LRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVS 652
+ K Q ++ + + I+ + I H L S + K+ +
Sbjct: 1555 VLKKYQRLLEKA-----REEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609
Query: 653 TPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712
+P PVP + +L E+ ++ AE + + L KL++ DL Q
Sbjct: 1610 SPTPVPTNKH---------FIRLAEM----EQTVAEQDDSLSSLLVKLKKVSQDLERQRE 1656
Query: 713 KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
++ LQ+N E +++ + E + L +QK+ Q + + Q + AN
Sbjct: 1657 ITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS 1716
Query: 773 KLAVAEVR--AENLK-----KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ----- 820
+ +R E LK KEK+ LS L + E A + + ++ Q
Sbjct: 1717 RAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAE--ERIISATSQKEAHL 1774
Query: 821 TIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
+Q I++R E K +Q+E L + LK+ L+ + ++LT NL+
Sbjct: 1775 NVQQIVDRHTRELK----TQVEDLNENLLKLKEALKTSKNRENSLTDNLN---------- 1820
Query: 881 DTETNLHLNTKELLKNA-QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED-VDDLV 938
+ N L K+ N +E + Q ++ Q+ +S GK NK+ +++L
Sbjct: 1821 --DLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ 1878
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
++++ E Q+ E + + + + EE + ++ E +R ++ + E
Sbjct: 1879 RKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI-EGIRNKLKEKEGEVF 1937
Query: 999 EFQTQLE--KKLM-EVEKEKQELQDDKR------------RAIESMEQQLSELKKTLSSV 1043
QL K L + +KEK LQ + RA+ES E++L ELKK +
Sbjct: 1938 TLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES-EKELEELKKRNLDL 1996
Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA--AKE 1101
+N++ RA AL + + QN+Y +E LHA + + + +K
Sbjct: 1997 ENDI--LYMRAHQALPRDSVVED---------LHLQNRYLQE-KLHALEKQFSKDTYSKP 2044
Query: 1102 QVSKMASV-----RQHLEETTQKAESQLLECKASWEERER---MLKDEVSKCVCRCEDLE 1153
+S + S Q L++ K S+ +E K E+ + LK++V CE L+
Sbjct: 2045 SISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLK 2104
Query: 1154 KQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETR 1213
K+ ++++ V S + G P E K+ + +++ ++RE E
Sbjct: 2105 KEKA----EVQRKLGHVRGSGRSGKTIP------ELEKTIGLMKKVVEKVQRENE----- 2149
Query: 1214 FEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQV-TAKTMAQHEELMKKTETMNVV 1272
++ + + +++ +E+E + L AE EK++ ++ H E KT+ +
Sbjct: 2150 -QLKKASGILTSEKMANIEQE----NEKLKAELEKLKAHLGHQLSMHYE--SKTKGTEKI 2202
Query: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDV 1332
+ N+ LR+E ++ ++++ LE+ L+EK + LEE
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEI-----------LNEKMTVQ------LEETG 2245
Query: 1333 KRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN 1392
KR + Q + D++ ++ ++ + TK + L+ +IA+ N S+T+
Sbjct: 2246 KRLQFAESR-GPQLEGADSKSWKSIVVTRMYETK--------LKELETDIAKKNQSITDL 2296
Query: 1393 QNLIQSLKEDLNKVRTEKETIQKDLDAKIID-IQEKVKTITQVKK---IGRRYKTQYEEL 1448
+ L++ E KV E +++ + KI+ + E +T +K+ + R Q ++
Sbjct: 2297 KQLVKEATEREQKVNKYNEDLEQQI--KILKHVPEGAETEQGLKRELQVLRLANHQLDKE 2354
Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKE 1508
KA+ +E + SG ++ + +LKE + ET+ K + + ++L++ + + +
Sbjct: 2355 KAELIHQIEANKDQSGAES----TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410
Query: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
E N + E+ L+ + ++ + L +++ + E+
Sbjct: 2411 KELENFDPSFFE---EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451
Score = 121 bits (304), Expect = 7e-27
Identities = 259/1299 (19%), Positives = 530/1299 (40%), Gaps = 205/1299 (15%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
Q L R LP + Q K K + Q++ K K+ E + + E R
Sbjct: 1268 QSLRRQFSGALPLAQQEKFSKTMIQLQND---------KLKIMQEMKNSQQEHR------ 1312
Query: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNK------ELEIAQDRNIAIQSQFTRTKEEL 120
+ N+T E + LE+L + LK K ++E + + + + + + KEE+
Sbjct: 1313 NMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEI 1372
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
+ + +S E + + K E+ + + +L+ +LD +
Sbjct: 1373 KYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAA 1432
Query: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
++ E+ + + L +L+ ++ +E ILE + ++ +E +L+E+
Sbjct: 1433 QKFEEATGSIPDPSLPLPNQLEIALRKI----KENIRIILETRATCKSLEE---KLKEKE 1485
Query: 241 NGLKTSNEHL---QKHVEDLLTKLKEAKEQQA--------SMEEKFHNELN-AHIKLSNL 288
+ L+ + +++ K + +L +L E++ ME K H+ L AH ++N+
Sbjct: 1486 SALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545
Query: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
+A+ N+ +++ +LL++A E + I K + + +L R
Sbjct: 1546 --------QARLNQKEEVLKKYQRLLEKAREEQREIV--------KKHEEDLHILHH--R 1587
Query: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
LE + +++ + T +L SPT K ++L E+ E D
Sbjct: 1588 LELQADSSLNKFKQTAW--------DLMKQSPTPVPTNKHF---IRLAEMEQTVAEQDDS 1636
Query: 409 LLLEKLENKRINKYLD---EI----VKEVE-AKAPILKRQREEYERAQKAVASLSVKLEQ 460
L ++ K++++ L+ EI VKE E K + + +E ++ + V L L+Q
Sbjct: 1637 LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1696
Query: 461 AMKEIQRLQEDTD---KANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEARGNHV 515
+ KE Q L+ + +AN ++ N R++ Q+ +Q + L L E R
Sbjct: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756
Query: 516 IRDEE-VSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
EE + SA + + Q +V R+ EL+ Q + L L +L +E +T+ +
Sbjct: 1757 AAAEERIISATSQKEAHLNVQQIVD-RHTRELKTQVEDLNENLLKL-----KEALKTSKN 1810
Query: 575 KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
+ L L EL++ +K+ ++ + I ++ D + + + T L L
Sbjct: 1811 RENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTS---GLQGKPLT 1867
Query: 635 DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN 694
D Q++ V + +E K L+ + K++ A+ E I+
Sbjct: 1868 D-----------NKQSLIEELQRKVKKLENQLEGKVEEVDLKPM----KEKNAKEELIRW 1912
Query: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
E+ +K Q ++ +R++ + ++ +K+ L+D +E +L +KL T
Sbjct: 1913 EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ---RKLKTTGM 1969
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
+Q++ +R + + E++ NL E ++L + + R+S++ + QN
Sbjct: 1970 TVDQVLG-----IRALESEKELEELKKRNLDLENDILYM-RAHQALPRDSVVEDLHLQNR 2023
Query: 815 LLT---------------NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE--- 856
L + +I GI + +Q L + KL E LK +LE
Sbjct: 2024 YLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQAN 2083
Query: 857 -------NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS 909
N+V + L + + +R+L + K + +K I +K+ +
Sbjct: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI-PELEKTIGLMKKVVE 2142
Query: 910 NME---VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV-NDLKERLKTSTSNVEQY 965
++ Q+ S T + + +++ + L ++L + + + + L ++ T E+
Sbjct: 2143 KVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202
Query: 966 QAMVTSLEESLNKEKQVTEEVR---KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK 1022
A L + L KE E++R N+E+ ++ + K+L E +L+
Sbjct: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262
Query: 1023 RRAIESM------EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR---DCQEQAK 1073
++ +S+ E +L EL+ ++ + + Q A EQ+ + D ++Q K
Sbjct: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK 2322
Query: 1074 I------AVEAQNKYERELML-----HAADVEA------LQAAKEQVSKMASV--RQHLE 1114
I E + +REL + H D E ++A K+Q +++ L+
Sbjct: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382
Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE------------------KQN 1156
E + E+QL K S E++ LK+E+ K E+ + K+N
Sbjct: 2383 EKIKDLETQL---KMSDLEKQH-LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKN 2438
Query: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195
LL ++++KLS+++ GV+ V+ SEE + +E+
Sbjct: 2439 ILLEEKVKKLSEQL------GVELTSPVAASEEFEDEEE 2471
Score = 115 bits (289), Expect = 4e-25
Identities = 231/1062 (21%), Positives = 445/1062 (41%), Gaps = 149/1062 (14%)
Query: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL--KALTEKNKE-LEIAQ 103
K++ ++ + ++ S+++++NE R E EKL +L K + K+ L+IA
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539
Query: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK---ESNTTKG 160
+Q++ + +E L+ +R L + E + ++ ED+ L+ +L+ +S+ K
Sbjct: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599
Query: 161 ELQLKLDELQASDVSVKYREK--RLEQEKELLHSQNTWLNT---ELKTKTDELLALGREK 215
+ Q D ++ S V + RL + ++ + Q+ L++ +LK + +L E+
Sbjct: 1600 K-QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL-----ER 1653
Query: 216 GNEILELKCN---------LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
EI ELK EN ++EV +++ ++ LK + QK + L ++L+ KE
Sbjct: 1654 QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKE 1713
Query: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE-----AN 321
+ L +K K E + L+RA+ EL + A E A
Sbjct: 1714 ANSRAPTTTMRNLVERLKSQLALK------EKQQKALSRALLELRAEMTAAAEERIISAT 1767
Query: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL------------------ENANDLLSAT 363
+ HL V+Q D+ +E+ ++ L + L +N NDL +
Sbjct: 1768 SQKEAHL-NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826
Query: 364 KRK----GAILSE-EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK- 417
++K IL E EE+ + K + G++ L + Q L+E+L+ K
Sbjct: 1827 QKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTD-----NKQSLIEELQRKV 1881
Query: 418 -RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
++ L+ V+EV+ K K +EE R ++ K+E +++ + +
Sbjct: 1882 KKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEG-KKWQAKIEGIRNKLKEKEGEVFTLT 1940
Query: 477 KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE----EVSSADISSSSEV 532
KQ + L+ + + + L ++++ M +++ G + E E+ ++ +++
Sbjct: 1941 KQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI 2000
Query: 533 I----SQHLVSYRNIEELQQQNQRLLVALRELGETRERE----------EQETTSSKITE 578
+ Q L +E+L QN+ L L L + ++ E + + E
Sbjct: 2001 LYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE 2060
Query: 579 LQ---LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
LQ LKL S EL+ QL ++ + +L + + ++M L + V L
Sbjct: 2061 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG----- 2115
Query: 635 DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKA--ENEKI 692
+ + + T +P +E T + K ++++Q E KK +EK+
Sbjct: 2116 --HVRGSGRSGKT---------IPELEKTIGL-MKKVVEKVQRENEQLKKASGILTSEKM 2163
Query: 693 QN--EQLEKLQEQVTDLRSQ-NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
N ++ EKL+ ++ L++ ++S + +K E + E R+E+ + +KL
Sbjct: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKL 2223
Query: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK--KEKEMLKLSEVRLSQQR-ESLL 806
E + MT L ++L AE R L+ K + R+ + + + L
Sbjct: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELE 2283
Query: 807 AEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
+ +N +T+L+ L + TE +Q+++ E LE +I LK E E L
Sbjct: 2284 TDIAKKNQSITDLKQ----LVKEATEREQKVNKYNEDLEQQIKILKHVPEG-AETEQGLK 2338
Query: 867 RNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG 926
R L V L QLD KE A L + +E ++ T
Sbjct: 2339 RELQVLRL-ANHQLD-----------------KEKAEL---IHQIEANKDQSGAESTIPD 2377
Query: 927 QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEV 986
KE + DL +QL+ ++ + LKE +K +E + + EE + + EEV
Sbjct: 2378 ADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP--SFFEEIEDLKYNYKEEV 2435
Query: 987 RKNI--EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
+KNI E ++K+ +E QL +L +E +D++ +
Sbjct: 2436 KKNILLEEKVKKLSE---QLGVELTSPVAASEEFEDEEESPV 2474
Score = 60.8 bits (146), Expect = 1e-08
Identities = 104/493 (21%), Positives = 211/493 (42%), Gaps = 56/493 (11%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDG------LKGRHEKFKVESEQQYFEIE 58
L+ E EL K ++N + A Q D L+ R+ + K+ + ++ F +
Sbjct: 1980 LESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKD 2039
Query: 59 KRLSHSQERLVNET-----RECQSLRLELEKLNNQLK-ALTEKNKELEIAQD--RNIAIQ 110
S + ++ +E Q L+L N +LK L + NK+L ++ R++
Sbjct: 2040 TYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEM 2099
Query: 111 SQFTRTKEELEAEKRDLIRTNERLSQ---ELEYLTEDVKRLNEKLKESNTTKGELQLKLD 167
+F + ++ K +R + R + ELE +K++ EK++ N QLK
Sbjct: 2100 CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE-----QLK-- 2152
Query: 168 ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL----------KTKTDELLALGREKGN 217
+AS + + +EQE E L ++ L L KTK E + E+
Sbjct: 2153 --KASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENER-- 2208
Query: 218 EILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHN 277
L+ L+ + + +L N L+ NE + +E+ +L+ A+ + +E
Sbjct: 2209 ----LRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 2264
Query: 278 ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
+ I ++ +Y++ + E + +++ +L +L+KEA E + + + ++EQ
Sbjct: 2265 SWKS-IVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKI 2323
Query: 338 MEK--EMLEKIGRLEKELEN---ANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
++ E E L++EL+ AN L K K ++ + E A + A + I
Sbjct: 2324 LKHVPEGAETEQGLKRELQVLRLANHQLD--KEKAELIHQIE--ANKDQSGAESTIPDAD 2379
Query: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
+L + + QL + LE + + + + ++ KE+E P + E+ + K
Sbjct: 2380 ----QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV 2435
Query: 453 SLSVKLEQAMKEI 465
++ LE+ +K++
Sbjct: 2436 KKNILLEEKVKKL 2448
Score = 50.8 bits (120), Expect = 2e-05
Identities = 50/239 (20%), Positives = 114/239 (47%), Gaps = 20/239 (8%)
Query: 1394 NLIQSL-KEDLNKVRTEKETIQKDL-----DAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
NL+ SL K ++N++++EK+ L + QE + +V+K G +
Sbjct: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ 86
Query: 1448 LKAQQDKV---METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
LK + K+ +E + QS+G ++ + L+ + Q E + + + ++E+++K L
Sbjct: 87 LKTKVMKLENELEMAQQSAGG--------RDTRFLRNEICQLEKQLEQKDRELEDMEKEL 138
Query: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKI 1564
+++ L + + ++E S+LR++ + + EQL Q I + +++ S+
Sbjct: 139 EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRR 198
Query: 1565 AHLAGVKDQLTKENEELKQ---RNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
+ + QL+K+N EL Q L + ++++V+ ++ E + +E+ E+
Sbjct: 199 GEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEY 257
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 199 bits (506), Expect = 3e-50
Identities = 315/1522 (20%), Positives = 641/1522 (42%), Gaps = 179/1522 (11%)
Query: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLA--LG 212
S T G + KL+ L D+ +K+ +K++ +L + TEL+ + +EL + +
Sbjct: 11 SPATPGTGKSKLETLPKEDL-IKFAKKQM-----MLIQKAKSRCTELEKEIEELRSKPVT 64
Query: 213 REKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
G+ I L L+ E + E+Q LK N +++ VED +TK+ +A
Sbjct: 65 EGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDA-------- 116
Query: 273 EKFHNELN-AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
H EL +HI ++ ++ A ++ + L K L+EA + + L
Sbjct: 117 ---HKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 332 EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
S+D ++K + E+I ++ E +L K+ A E++ T + I++
Sbjct: 174 NNSEDNVKK-LQEEIEKIRPGFEE--QILYLQKQLDATTDEKK-----ETVTQLQNIIEA 225
Query: 392 GMKLTELYNAYVET-QDQLL----LEKLENKRINKYLDEIVKEVEAKAPILKRQREEY-E 445
++ Y + + Q++LL + + E K + ++ KE EA+ L +E +
Sbjct: 226 N---SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVK 282
Query: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLM 505
+ + + ++ K E ++ +++ + ++ N+ S+L ++N +E V + + + L
Sbjct: 283 QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLK 342
Query: 506 ELEEARGNHVIRDEEVSSADISSSSEVISQHLVS--YRNIEELQQQNQRLLVALRELGET 563
ELE +++DE ++ E+ +QH+ + E+L+ + LL+A E G
Sbjct: 343 ELESQHS--ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400
Query: 564 REREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
E+ + E + +E E++ L++ QHQ ++
Sbjct: 401 IEKLKSELAGLN-KQFCYTVEQHNREVQSLKE--QHQKEI-------------------- 437
Query: 624 VAIPLHASSLDDVSLASTPKRPSTS----QTVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
S L++ L+ + K T Q + E EAI +L+++ EI
Sbjct: 438 -------SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490
Query: 680 ENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI 739
+ E A KI E Q+Q +D+ K+ T E + + ++G ++
Sbjct: 491 QTELGESAG--KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV-NRLQGENEKL 547
Query: 740 TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE----MLKLSE 795
S E +L T + ++ L + L E + +L +EK+ LK S
Sbjct: 548 LSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607
Query: 796 VRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKK 854
+ + E+R +L + Q I SE E K L+ +E+ E +K
Sbjct: 608 EEMDNFHKKCEREER--LILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQK 665
Query: 855 LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN-----AQKEIATLKQHLS 909
LE + Q L+ + +V + K + L K+L ++ +QKE LK+H++
Sbjct: 666 LEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725
Query: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV 969
+E ++ ++ + E V L + + L LK S V
Sbjct: 726 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQ--------LYGFLKEMGSEVS------ 771
Query: 970 TSLEESLNKEK-QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK------ 1022
E+S K+ V + V +++ +E Q ++K++E+EKE + LQ++
Sbjct: 772 ---EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828
Query: 1023 -RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK 1081
+ + EQ+ L+K L +Q+E +EALQ + N + R + I VE ++
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSE-KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQ 887
Query: 1082 YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDE 1141
+ +H + E + + ++ + ++L+ K S + + D
Sbjct: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKE-----LRDRRAELILLKDSLAKSPSVKNDP 942
Query: 1142 VS---KCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198
+S + + E+LEK+ + ++I K+ V + KE L K + + E
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE---------LDSSRKETQTVKE 993
Query: 1199 ILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQ 1258
L +R EK+ + + + ++ + + L E ++ + L+ E+E+ +
Sbjct: 994 ELESLRSEKD----QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI-- 1047
Query: 1259 HEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS 1318
E+L ++ + ET + + E L ++ +Q+ + LE+ IL +Q A A + ++
Sbjct: 1048 -EDLTRQLRNSTLQCET---INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE- 1102
Query: 1319 GMLQAEKKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKLLSEKEVHTKRIQQLT---E 1373
L+AEK E+ +K L + Q + ++ +K + E E+ K QQ T
Sbjct: 1103 --LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160
Query: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQ 1433
EI + + N LTN N I+ L++++ + ++ET+Q+++ + +Q+ + T+
Sbjct: 1161 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1220
Query: 1434 VKKIGRRYKTQYEELK-AQQDK-VMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
+K++ + K + + K A+ D +++ S + + +Q V V ++Q L E ++ +
Sbjct: 1221 IKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHE 1279
Query: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
L++ E Q+TLS + LQE+ ++E + + + + + + +Q +K +
Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ--QKNK 1337
Query: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRIS 1611
+A E E KQ L+ D+L +++ ++ + +S
Sbjct: 1338 SMSQA--------------------ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVS 1377
Query: 1612 RLERELREHQ---ERHLEQRDE 1630
L+ EH ERH + E
Sbjct: 1378 ELQTLQSEHDTLLERHNKMLQE 1399
Score = 181 bits (460), Expect = 6e-45
Identities = 329/1625 (20%), Positives = 661/1625 (40%), Gaps = 264/1625 (16%)
Query: 3 AVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62
A LQ+ LE +L S Q K + + + + L+ EK + E+Q ++K+L
Sbjct: 150 ANLQKQLEEAMNTQLELSEQLKFQN---NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 63 HSQERLVNETRECQSL-RLELEKLNNQLKALTEKNKELE-IAQDRNIAIQSQFTRTKEEL 120
+ + + Q++ + + +L E+ +L+ I Q+ + Q + +E
Sbjct: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
Query: 121 EAEKRDLIRTNERLSQELEYLTEDVKR--------------------------------- 147
EAE L E L ++ E +++++
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFV 326
Query: 148 ---LNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTK 204
+NEK+K T EL+ + L+ + + +LE + + + + +L+ K
Sbjct: 327 EQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFK 386
Query: 205 TDELLALGREKGNEILELKCNLENKKEEVSRLEEQM-NGLKTSNEHLQKHVEDLLTKLKE 263
+ELL E+G C +E K E++ L +Q ++ N +Q E ++ E
Sbjct: 387 INELLLAKEEQG-------CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 439
Query: 264 AKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK----EAGE 319
E S EK +L ++ L K ++ + + E E L ++++ E GE
Sbjct: 440 LNETFLSDSEK--EKLTLMFEIQGL-KEQCENLQQEKQEAILNYESLREIMEILQTELGE 496
Query: 320 ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMS 379
+ I E E K Q ++ E +L + LL R E+L +
Sbjct: 497 SAGKISQ---EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG--ENEKLLSQQ 551
Query: 380 PTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK--RINKYLDEIVKEVEAKAPIL 437
+ +K + +Y + +D +L E LE K + + D+ + +++ +
Sbjct: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEM 610
Query: 438 KRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
++ ER ++ + L K+EQ ++ L++ K N+ + LE ++ KD +
Sbjct: 611 DNFHKKCEREERLILELGKKVEQTIQYNSELEQ---KVNELTGGLEE-----TLKEKDQN 662
Query: 498 -QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
Q++ L+++++ + D+EV SA++ S Y +L + ++L
Sbjct: 663 DQKLEKLMVQMKV-----LSEDKEVLSAEVKS----------LYEENNKLSSEKKQL--- 704
Query: 557 LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
R+L ++E IT+L+ KL+ + E + L K +++ V + + +Y
Sbjct: 705 SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ--VQKLFVKTQLYGF 762
Query: 617 LLSQTTGVAIPLHASSLDDVSLA---STPKRPSTSQTVSTPAPVPVIESTEAI-----EA 668
L + V+ + +V A S K ++ V+E + I E+
Sbjct: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822
Query: 669 KAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
++L+ + +Y++EK E E+IQ+E+ E LQ + ++++ N K T+L+
Sbjct: 823 VVQCEELKSLLRDYEQEKVLLRKELEEIQSEK-EALQSDLLEMKNANEK--TRLE----- 874
Query: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
NQ L ++ Q + ++ EK + E ENL
Sbjct: 875 ---------------------NQNLLIQVEEVSQTCS--KSEIHNEKEKCFIKE--HENL 909
Query: 785 KK--EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIE 842
K E++ L+ L ++SL +N L++++ ++ +E E E K++ +I
Sbjct: 910 KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEK-EEKIN 968
Query: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
K++ KK+L++ ++ T+ L+ L K QL + ++L++ A+
Sbjct: 969 KIKLVAVKAKKELDSSRKETQTVKEELE-SLRSEKDQLSA------SMRDLIQGAES--- 1018
Query: 903 TLKQHLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTE---EQVN----DLKE 953
N+ ++ QS Q + + +N + ++DL QLR + E +N DL
Sbjct: 1019 -----YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073
Query: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
R++T SN + + + ++ + + E + E ++KE A +LE+ ++++K
Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQK 1133
Query: 1014 EKQELQD--DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQ 1071
EK++LQ + ++ QQ + + ++ + ++E Q+ L+N+ D +++
Sbjct: 1134 EKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNKNNKIEDLEQE 1189
Query: 1072 AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASW 1131
KI + Q E LQ E+++ + S Q EE K + L++ K
Sbjct: 1190 IKIQKQKQ--------------ETLQ---EEITSLQSSVQQYEEKNTKIKQLLVKTK--- 1229
Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
+ L D + +D ++ ++ ++G L S +
Sbjct: 1230 -------------------------KELADSKQAETDHLI--LQASLKGELEASQQQVEV 1262
Query: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQEL---QDSLNAERE- 1247
+ Q+ EI + E +T E Q Y+QRV L+ E + Q ++ +E E
Sbjct: 1263 YKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFES 1322
Query: 1248 -KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI-L 1305
KV+V Q + M + ET ++E+E LE + Q++ K++ + ++ +
Sbjct: 1323 YKVRVHNVLKQQKNKSMSQAETEGA--------KQEREHLEMLIDQLKIKLQDSQNNLQI 1374
Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
+ E SE +L+ K+L+E V + + L S Q + + K HT
Sbjct: 1375 NVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSEN--------MMMKSEHT 1426
Query: 1366 KRIQQLTEEIGRLKAEIARSNASL-TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDI 1424
+ + QLT + L+ L ++ +++L++ L+K+ + ++ + +
Sbjct: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTR---- 1482
Query: 1425 QEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLN 1484
V + +K + R T L E + D + + Q L++ LN
Sbjct: 1483 -SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
Query: 1485 QAETKSK--------SLESQVENLQKTLSE--------KETEARN--LQEQTVQLQSELS 1526
ETK + + E V+ L T +ETEA N L EQ L+SE+
Sbjct: 1542 SPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIR 1601
Query: 1527 RLRQD 1531
RL ++
Sbjct: 1602 RLERN 1606
Score = 117 bits (294), Expect = 1e-25
Identities = 183/866 (21%), Positives = 361/866 (41%), Gaps = 125/866 (14%)
Query: 835 QRLSSQIEKLEHEISHLKKK--LENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
Q+ S+ +LE EI L+ K E + LT LD LL+ T++
Sbjct: 42 QKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAE-----------TEQ 90
Query: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
+ +KE +KQ + + ++ ++KE ++ +++ E N+L
Sbjct: 91 QCLSLKKENIKMKQEVEDSVTKMGD-----------AHKELEQSHINYVKEIENLKNELM 139
Query: 953 E-RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEV 1011
R K S E+ N +KQ+ E + N ++ L E +FQ E + ++
Sbjct: 140 AVRSKYS--------------EDKANLQKQLEEAM--NTQLELSEQLKFQNNSEDNVKKL 183
Query: 1012 EKEKQELQDDKRRAIESMEQQLS----ELKKTLSSVQNEVQEALQRASTALSNEQ----Q 1063
++E ++++ I +++QL E K+T++ +QN ++ Q +++ Q Q
Sbjct: 184 QEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQ 243
Query: 1064 ARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQ------------ 1111
+ QE+ K E + E H A++ L KE + K +
Sbjct: 244 LKAIHQEEVK---ELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELE 300
Query: 1112 HLEETTQKAESQLLECKASWEER---ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD 1168
+L + T A C +E E+++ ++V ++LE Q+ +L D++ +++
Sbjct: 301 NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNN 360
Query: 1169 KVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKE---IAETRFEVA-------- 1217
+ ++ Q + E + +I E+L + +E++ I + + E+A
Sbjct: 361 -LKLKLEMDAQHIKDEFFHEREDLEFKINELL--LAKEEQGCVIEKLKSELAGLNKQFCY 417
Query: 1218 -------QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN 1270
+V+SL+ + + E+ E L DS E+EK+ + + E+ +
Sbjct: 418 TVEQHNREVQSLKEQHQKEISELNETFLSDS---EKEKLTLMFEIQGLKEQCENLQQEKQ 474
Query: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA--ELSEKSGMLQAEKKLL 1328
+ + LRE E L+ +L + K+ + E + + Q+A+ EL +K EK L
Sbjct: 475 EAILNYESLREIMEILQTELGESAGKISQ-EFESMKQQQASDVHELQQKLRTAFTEKDAL 533
Query: 1329 EEDVKRWKARNQHLVSQQK-DPDTEEYRKLLSEKE-VHTKRIQQLTEEIGRLKAEIARSN 1386
E V R + N+ L+SQQ+ P+ E K L EK V+ + Q + L+ +I N
Sbjct: 534 LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI---N 590
Query: 1387 ASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE 1446
+ + I LK E + K + + I E K + Q + + +
Sbjct: 591 SLTEEKDDFINKLKNS----HEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 1447 ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
EL ++ ++ Q+ ++ V ++ + E KE L+ AE KS E+ + +K
Sbjct: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS-AEVKSLYEENNKLSSEKKQLS 705
Query: 1507 KETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA------ 1560
++ E Q++ V L+ +++L + LQ +++ L + + + E+ +K V
Sbjct: 706 RDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL--ENEQVQKLFVKTQLYGFL 763
Query: 1561 -------------KSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYE 1607
K + L V + L K NEE D++ EL+ I L+ +
Sbjct: 764 KEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESV 823
Query: 1608 GRISRLERELREHQERHLEQRDEPQE 1633
+ L+ LR++++ + R E +E
Sbjct: 824 VQCEELKSLLRDYEQEKVLLRKELEE 849
Score = 80.9 bits (198), Expect = 1e-14
Identities = 98/439 (22%), Positives = 189/439 (43%), Gaps = 85/439 (19%)
Query: 1261 ELMKKTETMNVVMETNKMLREEKER---LEQDLQQMQAKVRKLELDILPLQEANAE---- 1313
E + K + + + ++++ K R LE++++++++K P+ E +
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK---------PVTEGTGDIIKA 73
Query: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE--EYRKLLSEKEV-HTKRIQQ 1370
L+E+ L EK E+ K N + + +D T+ + K L + + + K I+
Sbjct: 74 LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN 133
Query: 1371 LTEEIGRLKAEIARSNASL---------------------TNNQNLIQSLKEDLNKVRTE 1409
L E+ ++++ + A+L N+++ ++ L+E++ K+R
Sbjct: 134 LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193
Query: 1410 KET----IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYE-----------ELKA-QQD 1453
E +QK LDA EK +T+TQ++ I Y+ +LKA Q+
Sbjct: 194 FEEQILYLQKQLDATT---DEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQE 250
Query: 1454 KVMETSAQSSGDHQEQHVSVQEMQELKETL-NQAETKSKSL----ESQVENLQKTLSEKE 1508
+V E Q +E + ++ ELKE L Q E K++ E ++ENL+K S
Sbjct: 251 EVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNAN 310
Query: 1509 TEARN----LQEQTVQLQ---SELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
+ + LQE T Q ++ L L++ +Q L+ ++T K + A+
Sbjct: 311 QDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQ 370
Query: 1562 SKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEG-------RISRLE 1614
+KD+ E E+L+ + L K+E I LKS+ G + +
Sbjct: 371 H-------IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN 423
Query: 1615 RELREHQERHLEQRDEPQE 1633
RE++ +E+H ++ E E
Sbjct: 424 REVQSLKEQHQKEISELNE 442
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 187 bits (476), Expect = 8e-47
Identities = 243/1181 (20%), Positives = 525/1181 (44%), Gaps = 136/1181 (11%)
Query: 528 SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQ----ETTSSKITELQLKL 583
++ +V+ ++ +Y + Q RL ++ L + +EE+ E K+ E QL
Sbjct: 807 TAMKVLQRNCAAYLKLRNWQWW--RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAA 864
Query: 584 ESALTELEQLRKSRQ-HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
E+ LTE+E L+ ++QL + + + ++ + +++ T
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAETEL----------------CAEAEELRARLTA 908
Query: 643 KRPSTSQTVSTPAPVPVIESTEAI-----EAKAALKQLQEIFENYKKEKAENEKIQNEQ- 696
K+ + + V E E E K + +QE+ E ++E++ +K+Q E+
Sbjct: 909 KKQELEE-ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967
Query: 697 -----LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
L+KL+E+ L QN K++ K ++L+D + + +T E+++ L
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLA-------KEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
K E +I + E+L E + + L+K + L+ LS Q L A+
Sbjct: 1021 LKNKHEAMITDL-------EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 812 QNLLLTNLQT-IQGILERSETETKQRLSS--QIEKLEHEISHLKKKLENEVEQRHTLT-- 866
+ L + +Q L R E E Q+ + +I +LE +IS L++ LE+E R+
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 867 -RNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
R+L +L K +L+ + +EL ++E+ LK+ L +Q + K
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193
Query: 926 GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN----VEQYQAMVTSLEESLNKEKQ 981
+ + V++L QL QT+ +L++ +T + + + ++ +S +K K+
Sbjct: 1194 ----HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 982 VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLS 1041
V ++++ ++V+ E +T+L K+ +++ E D+ + + + S+L K S
Sbjct: 1250 VEAQLQE-LQVKFNEGERVRTELADKVTKLQVEL----DNVTGLLSQSDSKSSKLTKDFS 1304
Query: 1042 SVQNEVQ---EALQRA-------STALSNEQQARRDCQEQAKIAVEAQNKYERELM-LHA 1090
++++++Q E LQ ST L + + +EQ + EA++ E+++ LHA
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 1091 ADVEALQAAKEQVSKMAS---VRQHLEETTQKAESQLLECKASWEERERM---LKDEVSK 1144
+ + ++ V + + V++ L++ + + E A++++ E+ L+ E+
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 1145 CVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR 1204
+ D ++Q+ ++ +K D+++A K E +++E+ + L R
Sbjct: 1425 LLVDL-DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 1205 REKEIAETRFEVAQVESLRYRQRVELLE---------RELQELQDSLNAEREKVQVTAKT 1255
+E E + A++E L + R E+ + + + EL+ S A ++V+
Sbjct: 1484 ALEEAMEQK---AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQ--QMQAKVRKLELDILPLQEANAE 1313
+ + E+ ++ TE + +E N L+ K + E+DLQ Q++ +K +L + ++E AE
Sbjct: 1541 LEELEDELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQL-VRQVREMEAE 1597
Query: 1314 LSEKS---GMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT--EEYRKLLSEKEVHTKRI 1368
L ++ M A +K LE D+K +A H+ S K+ D ++ RKL ++ + + +
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEA---HIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK- 1427
+ A+ + L + + + L+E+L K Q++ D +I
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714
Query: 1428 ---VKTITQVKKIGRRYKTQYEELKAQQ-------DKVMETSAQSSGDHQEQHVSVQEMQ 1477
+ + +++ R EEL+ +Q D++ + + Q + + ++ Q
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ 1774
Query: 1478 ELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
+ + Q E ++K L+ +++ ++ T+ K + L++++++L + L + T
Sbjct: 1775 KNENARQQLERQNKELKVKLQEMEGTVKSK------YKASITALEAKIAQLEEQLDNETK 1828
Query: 1538 QEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDV 1597
+ + +Q+ E+K + ++ + + KDQ K + LKQ L++ ++E
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ- 1887
Query: 1598 RITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKV 1638
R A + +L+REL + E E NK+
Sbjct: 1888 RANASR-------RKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 164 bits (416), Expect = 7e-40
Identities = 238/1193 (19%), Positives = 510/1193 (42%), Gaps = 133/1193 (11%)
Query: 401 AYVETQDQLLLEKLENKRINKYLD-------EIVKEVEAKAPILKRQREEYERAQKAVAS 453
A+ + Q QL K+ + YL + +V+ P+L+ R+E E K
Sbjct: 798 AFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVK---PLLQVSRQEEEMMAKEEEL 854
Query: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
+ V+ +Q E RL T+ QS ++ ++Q+++ Q L E EE R
Sbjct: 855 VKVREKQLAAE-NRL---TEMETLQSQLMAE-----KLQLQEQLQAETELCAEAEELRAR 905
Query: 514 HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
+ +E+ + V + + LQ + +++ ++EL E E EE
Sbjct: 906 LTAKKQELEEICHDLEARVEEEE----ERCQHLQAEKKKMQQNIQELEEQLEEEES---- 957
Query: 574 SKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSL 633
+L+LE TE + L+K + Q+ L D + ++L + L
Sbjct: 958 ---ARQKLQLEKVTTEAK-LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 634 DDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQ 693
SLA + T + E + + KQ QE+ + +K + ++ +
Sbjct: 1014 KSKSLAKLKNKHEAMIT----------DLEERLRREE--KQRQELEKTRRKLEGDSTDL- 1060
Query: 694 NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE-------MLQDNVEGYRREITSLHERN 746
++Q+ +LQ Q+ +L+ Q K +L A R E M + +I+ L E
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 747 QKLTATTQKQEQIINTMTQDLRGANEKL--AVAEVRAENLKKEKEMLKLSEVRLSQQRES 804
+ A+ K E+ + ++L +L + A+ + K +++ ++ + + E+
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 805 LLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
E + Q + + Q ++ + E+ E +TK R+ + +EK + + + + +L NEV+
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLE-QTK-RVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 865 LTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG 924
+ + + + QL E + N E ++ + T Q + + SQS ++
Sbjct: 1239 GKGDSEHKRKKVEAQLQ-ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
K +D L SQL+ T+E + + + + ++ ++Q + S E L +E++
Sbjct: 1298 K----LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353
Query: 985 EVRKNIEVRLKESAEFQTQLEKK---LMEVEKEKQELQDDKRRAIESMEQQLS---ELKK 1038
+ K I + A+ + ++E L E+ K++LQ D + E++++ +L+K
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 1039 TLSSVQNEVQEAL-----QRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
T + +Q E+ + L QR S ++Q + D + + A+ ER+
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD-------- 1465
Query: 1094 EALQAAKEQVSKMASVRQHLEETT-QKAESQLLECKASWEERERML-KDEVSKCVCRCED 1151
A A+E+ +K S+ + LEE QKAE + L + E + M KD+V K V E
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 1152 ----LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSE----------EGKSQEQIL 1197
LE+Q + Q+E+L D++ A+ ++ +N+ + + +S+E+
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585
Query: 1198 EILRFIRR-EKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER-EKVQVTAKT 1255
+++R +R E E+ + R + + + R + ++L ++L+ DS N R E ++ K
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDL--KDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 1256 MAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
AQ ++ M++ + R +E + ++ + K++ +E +++ LQE A
Sbjct: 1644 QAQMKDCMRELDDT----------RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT------EEYRKLLSEKEVHTKRIQ 1369
Q E+ L +++ + + +++ + EE + E+ R++
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKD-----------LD 1418
+ +I ++ ++ + N+N Q L+ +++ + + ++ L+
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 1419 AKIIDIQEKVKTITQVKKIG----RRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
AKI ++E++ T+ ++ RR + + +++ Q D + Q +
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST--- 1870
Query: 1475 EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
+++LK L +AE +++ + LQ+ L + A + + L+++L R
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 163 bits (413), Expect = 2e-39
Identities = 256/1252 (20%), Positives = 525/1252 (41%), Gaps = 193/1252 (15%)
Query: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
Q +R +EE+ A++ +L++ E+ LTE ++ + E +LQL+ ++LQA
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE------KLQLQ-EQLQA 891
Query: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
E L E E L ++ T EL+ +L A E+ L+ + ++
Sbjct: 892 --------ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ 943
Query: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKS 291
+ LEEQ+ +++ + LQ KLK+ +E+Q +E++ + KL+ K
Sbjct: 944 NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ-------NCKLAKEKKL 996
Query: 292 AADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-LE 350
D + LT E+ L K + I D LE +++ +++ LEK R LE
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD--LEERLRREEKQRQELEKTRRKLE 1054
Query: 351 KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLL 410
+ + +D ++ + + A L + AA+A++ + Q +
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA------------AQKNMA 1102
Query: 411 LEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQE 470
L+K+ + + + E+ +++E+ +R +A+K L +LE E+ E
Sbjct: 1103 LKKI--RELESQISELQEDLES-------ERASRNKAEKQKRDLGEELEALKTEL----E 1149
Query: 471 DTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSS 530
DT L+ + E++ K Q++ +L LEE H + +E+
Sbjct: 1150 DT---------LDSTAAQQELRSK-REQEVNILKKTLEEEAKTHEAQIQEMR-------- 1191
Query: 531 EVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ---------L 581
+H + + E +Q +R+ L + +T E E E + LQ
Sbjct: 1192 ---QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 582 KLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAS 640
K+E+ L EL+ + + + + +L D + + ++ L TG+ S D S
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTK----LQVELDNVTGL-----LSQSDSKSSKL 1299
Query: 641 TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN---EQL 697
T + + + E+ + + LKQ+++ +++++ E E+ ++ +Q+
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 698 EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
L QV D++ + L+ A + LQ ++EG L +R+++ A K E
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG-------LSQRHEEKVAAYDKLE 1412
Query: 758 QIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT 817
+ + Q+L L A NL+K+++ + LLAE++
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF-----------DQLLAEEK------- 1454
Query: 818 NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
+ E + R ++ + E + L + LE +EQ+ L R
Sbjct: 1455 -------TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER--------LN 1499
Query: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
+Q TE +++K+ + K + L++ +E QV +Q +++L
Sbjct: 1500 KQFRTEMEDLMSSKD---DVGKSVHELEKSKRALEQQVEEMKTQ------------LEEL 1544
Query: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE- 996
+L+ TE D K RL+ + QAM E L + +EE +K + +++E
Sbjct: 1545 EDELQATE----DAKLRLEVN------LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594
Query: 997 SAEFQTQLEKKLMEVEKEKQELQD--DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054
AE + + +++ M V K+ D D I+S + E K L +Q ++++ ++
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE- 1653
Query: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114
L + + +R + QAK + E E++ ++ A + AK Q +Q +
Sbjct: 1654 ---LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ------AQQERD 1704
Query: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174
E + + + + EE+ R L+ +++ E+ + L++D+++K + ++
Sbjct: 1705 ELADEIANSSGKGALALEEKRR-LEARIAQLEEELEEEQGNTELINDRLKKANLQI---- 1759
Query: 1175 KEGVQGPLNVSLSEEGKSQ--EQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
+ + LN+ S K++ Q LE R+ KE+ E+ +Y+ + LE
Sbjct: 1760 -DQINTDLNLERSHAQKNENARQQLE-----RQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQ 1292
++ +L++ L+ E ++ Q K + + E+ +K +V+++ + +E+ EQ Q
Sbjct: 1814 AKIAQLEEQLDNETKERQAACKQVRRTEKKLK-----DVLLQVD----DERRNAEQYKDQ 1864
Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
+L+ L+EA E + + ++ LE+ + A N+ + S
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Score = 158 bits (400), Expect = 5e-38
Identities = 237/1116 (21%), Positives = 478/1116 (42%), Gaps = 175/1116 (15%)
Query: 34 SEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALT 93
+E + L+ R K E E+ ++E R+ +ER CQ L+ E +K+ ++ L
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVEEEEER-------CQHLQAEKKKMQQNIQELE 949
Query: 94 EKNKELEIAQDRNIAIQSQFTRTK-EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL 152
E+ +E E A+ + + ++ T K ++LE E+ L N +L++E + L + + L
Sbjct: 950 EQLEEEESARQK-LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 153 KESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALG 212
E L ++ +A ++ R +R E++++ L L + +D++ L
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 213 REKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
+I ELK L K+EE+ Q + E QK++ L K++E + Q + ++
Sbjct: 1069 A----QIAELKMQLAKKEEEL-----QAALARVEEEAAQKNM--ALKKIRELESQISELQ 1117
Query: 273 EKFHNELNAHIKLSNLYKSAADDSEAKSNEL--------------TRAVEELHKLLKEAG 318
E +E + K + ++ EA EL ++ +E++ L K
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177
Query: 319 EANKAIQDHLLEVEQSKDQMEKEM---LEKIGRLEKELENANDLLSATKRKGAILSEEEL 375
E K + + E+ Q Q +E+ LE+ R++ LE A L +G + +E
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE--NERGELANE--- 1232
Query: 376 AAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKL-ENKRINKYL-DEIVK---EV 430
K++ G +E VE Q Q L K E +R+ L D++ K E+
Sbjct: 1233 ----------VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME 490
+ +L + + + K ++L +L+ + LQE+ + S+ L+
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ---ELLQEENRQKLSLSTKLK------- 1332
Query: 491 IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
QV+D R L E EEA+ N + + A ++ + + + EE++++
Sbjct: 1333 -QVEDEKNSFREQLEEEEEAKHN-LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 551 QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ 610
Q+ L L ++ EE+ K+ + + +L+ EL+ L HQ Q ++ ++
Sbjct: 1391 QKDLEGL-----SQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442
Query: 611 RDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKA 670
+ + LL++ ++ A ++ A R ++ +S + EA+E KA
Sbjct: 1443 QKKFDQLLAEEKTIS----AKYAEERDRAEAEAREKETKALSLARAL-----EEAMEQKA 1493
Query: 671 ALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
L++L + F ++ ++ + + +L++ L Q ++ TQL E L+D
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL-------EELED 1546
Query: 731 NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEM 790
++ L Q + A ++ DL+G +E ++ +K+K++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFER----------DLQGRDE---------QSEEKKKQL 1587
Query: 791 LKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISH 850
VR ++ E+ L ++R Q + +++L ++ LE I
Sbjct: 1588 -----VRQVREMEAELEDERKQRSM--------------AVAARKKLEMDLKDLEAHIDS 1628
Query: 851 LKKKLENEVEQRHTLTRNLDVQLLDTKRQLD----TETNLHLNTKE---LLKNAQKEIAT 903
K + ++Q R L Q+ D R+LD + + KE LK+ + E+
Sbjct: 1629 ANKNRDEAIKQ----LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 904 LKQHLSNME----------VQVASQSSQRTGKGQPS--NKEDVDDLVSQLRQ--TEEQVN 949
L++ L+ E ++A + + +GKG + K ++ ++QL + EEQ N
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 950 D--LKERLKTSTSNVEQYQA---MVTSLEESLNKEKQVTEEVRKNIEVRLKE-----SAE 999
+ +RLK + ++Q + S + +Q E K ++V+L+E ++
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 1000 FQ---TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ---- 1052
++ T LE K+ ++E++ +++ A + + + +LK L V +E + A Q
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 1053 --RASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
+AST L ++ + +E+A+ A ++ K +REL
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Score = 150 bits (379), Expect = 1e-35
Identities = 224/1064 (21%), Positives = 453/1064 (42%), Gaps = 140/1064 (13%)
Query: 662 STEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE--------KLQEQV---TDLRSQ 710
S + E A ++L ++ E K+ AEN + E L+ +LQEQ+ T+L ++
Sbjct: 841 SRQEEEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 711 NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR-- 768
++ +L + E + ++E + ER Q L A +K +Q I + + L
Sbjct: 899 AEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 769 -GANEKLAVAEVRAE-NLKK-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
A +KL + +V E LKK E+E + L + +E L E R TNL
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT-TNLT----- 1009
Query: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
E E + L+ K E I+ L+++L E +QR L + D+ D
Sbjct: 1010 ---EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQ----RTGKGQPSN-KEDVDDLVSQ 940
L EL K+ L+ L+ +E + A ++ R + Q S +ED++ +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 941 LRQTEEQVNDLKERLKTSTSNVEQ-------YQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
+ E+Q DL E L+ + +E Q + + E+ +N K+ EE K E +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSV---------- 1043
++E + +Q ++L E ++ + ++ + +A +++E + EL + +
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 1044 QNEVQEALQRASTALSNEQQARRDCQEQ-AKIAVEAQNKYERELMLHAADVEALQAAKEQ 1102
+ +V+ LQ + ++ R + ++ K+ VE N +L +D ++ + K+
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG---LLSQSDSKSSKLTKD- 1302
Query: 1103 VSKMASVRQHLEETTQKAESQLLECKASWEE--------RERMLKDEVSKCVCRCEDLEK 1154
S + S Q +E Q+ Q L ++ RE++ ++E +K +LEK
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK-----HNLEK 1357
Query: 1155 QNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Q LH Q+ + K+ SV G L + + K Q+ LE L EK A +
Sbjct: 1358 QIATLHAQVADMKKKMEDSV-----GCLETAEEVKRKLQKD-LEGLSQRHEEKVAAYDKL 1411
Query: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVME 1274
E + L++EL +L L+ +R+ K + ++L+ + +T++
Sbjct: 1412 EKTKTR----------LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA--- 1458
Query: 1275 TNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLL---EED 1331
EE++R E + ++ + K L + E AEL + + E + L ++D
Sbjct: 1459 ---KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515
Query: 1332 VKRWKARNQHLVSQQK---DPDTEEYRKLLSEKEVHTKRIQ----QLTEEIGRLKAEI-- 1382
V ++ H + + K + EE + L E E + + +L + +KA+
Sbjct: 1516 V----GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 1383 ---ARSNASLTNNQNLIQSLK------EDLNKVRTEKETIQKDLDAKIIDIQEKV----- 1428
R S + L++ ++ ED K R+ +K L+ + D++ +
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 1429 ---KTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
+ I Q++K+ + K EL + E AQ+ + ++ EM +L+E L
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 1486 AETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
AE + + + + L ++ + E+ +L++ +++L ++L++ E + +
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 1546 ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT----A 1601
+ + + + + +H ++NE +Q+ L++Q EL V++
Sbjct: 1752 LKKANLQIDQINTDLNLERSH--------AQKNENARQQ---LERQNKELKVKLQEMEGT 1800
Query: 1602 LKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
+KS+Y+ I+ LE ++ + +E+ + E Q +V ++++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Score = 110 bits (276), Expect = 1e-23
Identities = 185/932 (19%), Positives = 391/932 (41%), Gaps = 113/932 (12%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
+R EL K + KLE D +I L+ + + K++ ++ E++ L+ +E
Sbjct: 1042 QRQELEK----TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE--- 1094
Query: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
E + L+K+ ++E ++LE + + Q EELEA K +L
Sbjct: 1095 ----EAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 130 T--NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
T + QEL E + +K E E Q++ + Q +V+ ++LEQ K
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ-EMRQKHSQAVEELAEQLEQTK 1209
Query: 188 EL---LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
+ L L E +E+ L + KG+ E+K+++V +++
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDS--------EHKRKKVEAQLQELQVKF 1261
Query: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
E ++ + D +TKL+ + + + ++ + K + +S D++ E
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 305 RAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEML---EKIGRLEKELENANDLLS 361
R L LK+ + + ++ L E E++K +EK++ ++ ++K++E++ L
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 362 ATKRKGAILSEEELAAMS----PTAAAVAKIVKPGMKLTE-----LYNAYVETQDQLLLE 412
+ L +++L +S AA K+ K +L + L + + Q LE
Sbjct: 1382 TAEEVKRKL-QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 413 KLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV--KLEQAMK------- 463
K + K+ ++ L E K + AK +R R E E +K +LS+ LE+AM+
Sbjct: 1441 K-KQKKFDQLLAE-EKTISAKY-AEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497
Query: 464 -------EIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMEL---EEARGN 513
E++ L D K LE+ R +E QV+++ Q+ L EL E+A+
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557
Query: 514 HVIR--------DEEVSSADISS---SSEVISQHLVSYRNIEELQQQNQRLLVALRELG- 561
+ + ++ D S +++ Q +E+ ++Q + A ++L
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617
Query: 562 ETREREEQETTSSK--------ITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDM 613
+ ++ E +++K + +LQ +++ + EL+ R SR+ + + + ++
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE------EILAQAKEN 1671
Query: 614 YRILLS-QTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672
+ L S + + + ++ + + +R + ++ + + E +A +
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732
QL+E E E+ N ++ N++L+K Q+ + NT ++ + A K Q
Sbjct: 1732 AQLEEELE----EEQGNTELINDRLKKANLQIDQI---NTDLNLERSHAQKNENARQ--- 1781
Query: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQ-DLRGANEKLAVAEVRAENLKKEKEML 791
L +N++L Q+ E + + + + K+A E + +N KE++
Sbjct: 1782 --------QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833
Query: 792 KLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHL 851
R ++ + +L + + N + + +++ T KQ L Q+E+ E E
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDER---RNAEQYKDQADKASTRLKQ-LKRQLEEAEEEAQRA 1889
Query: 852 ---KKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
++KL+ E+E ++ ++ K +L
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 96.7 bits (239), Expect = 2e-19
Identities = 130/634 (20%), Positives = 265/634 (41%), Gaps = 77/634 (12%)
Query: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
Q++L+ KL S+ KL++ ++ S + L+ E+ K E+Q + +++ +
Sbjct: 1314 QELLQEENRQKL--SLSTKLKQVEDEKNSFREQLE-EEEEAKHNLEKQIATLHAQVADMK 1370
Query: 66 ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR 125
+++ + ++ KL L+ L+++++E A D+ +TK L+ E
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK-------LEKTKTRLQQELD 1423
Query: 126 DLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQ 185
DL+ + Q L + K+ ++ L E T +S KY E+R
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT----------------ISAKYAEERDRA 1467
Query: 186 EKELLHSQNTWLN-----TELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
E E + L+ E + EL L ++ E+ +L + ++ + V LE+
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK-- 1525
Query: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQ-QASMEEKFHNELNAHIKLSNLYKSAA---DDS 296
S L++ VE++ T+L+E +++ QA+ + K E+N + + + S
Sbjct: 1526 -----SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS 1580
Query: 297 EAKSNELTRAVEELHKLLKE-------AGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
E K +L R V E+ L++ A A K ++ L ++E D K E I +L
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL 409
K D + A S EE+ +A+ + KL + ++ Q++L
Sbjct: 1641 RKLQAQMKDCMRELDDTRA--SREEI---------LAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 410 LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
+ ++ + DE+ E+ + EE R + +A L +LE+ + +
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 470 EDTDKANKQSSVLERD----------NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
+ KAN Q + D N Q++ +++++V L E+E +
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 520 EVSSADISSSSEVISQHLVSYR-NIEELQQQNQRLLVALRELGETREREEQ-----ETTS 573
A I+ E + + +++++ ++L L ++ + R EQ + S
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869
Query: 574 SKITELQLKLESALTELEQLRKSRQH-QMQLVDS 606
+++ +L+ +LE A E ++ SR+ Q +L D+
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Score = 88.2 bits (217), Expect = 9e-17
Identities = 99/402 (24%), Positives = 182/402 (45%), Gaps = 51/402 (12%)
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD--IL 1305
KV+ + Q EE+M K E + V E K L E E + Q Q KL+L +
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVRE--KQLAAENRLTEMETLQSQLMAEKLQLQEQLQ 890
Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
E AE E L A+K+ LEE +AR + + E + L +EK+
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEE--------EEERCQHLQAEKKKMQ 942
Query: 1366 KRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQ 1425
+ IQ+L E++ + E AR K L KV TE + K L+ + I ++
Sbjct: 943 QNIQELEEQLE--EEESARQ--------------KLQLEKVTTEAKL--KKLEEEQIILE 984
Query: 1426 EKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL-N 1484
++ + + KK+ +D++ E + + + +E+ S+ +++ E +
Sbjct: 985 DQNCKLAKEKKL-------------LEDRIAEFTTNLT-EEEEKSKSLAKLKNKHEAMIT 1030
Query: 1485 QAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQ 1544
E + + E Q + L+KT + E ++ +L +Q +LQ++++ L+ L +EE+L+
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL---AKKEEELQA 1087
Query: 1545 QITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKS 1604
+ EE+ + +A K KI L +L ++ E + ++QK +L + ALK+
Sbjct: 1088 ALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 1605 QYEGRI--SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
+ E + + ++ELR +E+ + + E K E Q Q
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Score = 83.2 bits (204), Expect = 3e-15
Identities = 94/464 (20%), Positives = 195/464 (42%), Gaps = 70/464 (15%)
Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
++ +L+ R+E+E+ E+ +V + L E E LQ L AE+ ++Q
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET--LQSQLMAEKLQLQ---- 886
Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
E+L +TE E L +K+ LE+ ++A+V + E
Sbjct: 887 -----EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE------------- 928
Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEE 1374
E+ LQAEKK ++++++ + +Q + + +KL EK ++++L EE
Sbjct: 929 -ERCQHLQAEKKKMQQNIQE--------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 1375 IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQV 1434
+ + N L + L++ + TE+E K L AK+ + E + IT +
Sbjct: 980 ----QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLKNKHEAM--ITDL 1032
Query: 1435 KKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQ-ELKETLNQAETKSKSL 1493
++ RR + Q +EL+ + K+ GD + + E+Q ++ E Q K + L
Sbjct: 1033 EERLRREEKQRQELEKTRRKL-------EGDSTDLSDQIAELQAQIAELKMQLAKKEEEL 1085
Query: 1494 ESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKT 1553
++ + +++ ++K + ++E L+S++S L++DL+ + +Q + E+
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRE----LESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 1554 RKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRL 1613
+ L E E+ A + + + + + LK E
Sbjct: 1142 ------------------EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH 1183
Query: 1614 ERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
E +++E +++H + +E E + + + ERG
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227
Score = 66.6 bits (161), Expect = 3e-10
Identities = 80/383 (20%), Positives = 163/383 (42%), Gaps = 39/383 (10%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
L+ L+ TE KL V L+ A + ++ G + E+ K + +Q E+E L
Sbjct: 1544 LEDELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
Query: 65 QERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQ-FTRTKEELEAE 123
+++ + L ++L+ L + + KN++ I Q R + Q + R ++ A
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDS-ANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL------QASDVSVK 177
+ +++ + ++L+ + ++ +L E+L + K + Q + DEL + ++
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720
Query: 178 YREKR--------LEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGNEILELK 223
EKR LE+E E +N LK ++ L L R + +
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 224 CNLENKKEEVSRLEEQMNGL-----KTSNEHLQKHVEDLLTKL-KEAKEQQASMEEKFHN 277
LE + +E+ ++M G K S L+ + L +L E KE+QA+ ++
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 278 E---------LNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
E ++ + + YK AD + + +L R +EE + + A + + +Q L
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 329 LEVEQSKDQMEKEMLEKIGRLEK 351
+ ++ D M +E+ +L +
Sbjct: 1901 EDATETADAMNREVSSLKNKLRR 1923
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 186 bits (473), Expect = 2e-46
Identities = 388/1957 (19%), Positives = 785/1957 (40%), Gaps = 295/1957 (15%)
Query: 19 KSVQNKLEKFLADQQSEIDGL----KGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRE 74
K QNK++K + D E + L K +HE +ESE +++R S + +
Sbjct: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195
Query: 75 CQSLRLELEKLNNQLKALTE--KNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTN- 131
+ + L+ N QL L +NKEL++ + + + + EL+ + DL +N
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQES-----EKEKECLQHELQTIRGDLETSNL 1250
Query: 132 -ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
+ SQE+ L + EK Q LQ S + + LE+ E+L
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
Query: 191 HSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE----EQMNGLKTS 246
++ L TEL E + R+ E+ +L ++ ++ L E + G +
Sbjct: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370
Query: 247 NEHLQKH------------VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
+ ++H E L KE + A ++EKF + + H L + + +
Sbjct: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMS- 1429
Query: 295 DSEAKSNELTRAVEELH--------KLLKEAGEANKAIQ----DHLLEVEQSKDQMEKEM 342
+K +EL V+ L L G+ K +Q + L+ S +
Sbjct: 1430 ---SKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSS 1486
Query: 343 LEKIGR---LEKELENANDLLSATKRKGAILS-------------EEELAAMSPTAAAVA 386
L +G LE D+ + +GA+ + +EE T +A A
Sbjct: 1487 LSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546
Query: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRI--NKYLDEIVKEVEAKAPILKRQREEY 444
K V+ L E+Y +E L EK+E++ I NK + E+ + + ++ L R++Y
Sbjct: 1547 KGVEELESLCEVYRQSLEK----LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602
Query: 445 ----ERAQKAVASLSVKLEQAMK-------------EIQRLQE-------------DTDK 474
E+ Q+ + S+++++E + E+ RLQ DT+
Sbjct: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTED 1662
Query: 475 A------------NKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
A S ER + Q+ D Q + L +++E+ ++
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQ-QDLNLDIEKITETGAVKPTGEC 1721
Query: 523 SADIS--------------SSSEVISQHLVSYRN--------------------IEELQQ 548
S + S SSE IS+ S N ++E
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 549 QNQRLLVALRELGETRER--EEQETTSSKI----TELQLKLESALTELE----QLRKSRQ 598
+N RLL + + E E + SK+ +L K+E+ + ELE +L+K
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI-ELEKIVGELKKENS 1840
Query: 599 HQMQLVD--SIVRQRDMYRILLSQTTGVAIPLHA--SSLDDVSLASTPKRPSTSQTVSTP 654
+ ++ S Q + R+ S+ + +HA SS +D+ S +
Sbjct: 1841 DLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF--- 1897
Query: 655 APVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKI----QNEQLEK----LQEQVTD 706
+ V I ++ A + + ++ E + EK+ NE +K L+E+++
Sbjct: 1898 --LDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV 1955
Query: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN-------QKLTATTQKQEQI 759
+ S+ ++ +LD SK+ L E + + L Q A +++ ++
Sbjct: 1956 VTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL 2015
Query: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
+ T++ D+ + + + ++L+K+ + L L++ L Q L E+ LL+
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE---LLVKES 2072
Query: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
+++Q L S+ E K +S +E E +L + E+ H L R ++ L + +
Sbjct: 2073 ESLQARLSESDYE-KLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG--IEKLRVRIE 2129
Query: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNME--VQVASQSSQRTGKGQPSNKEDVDDL 937
D + LH+ K LK ++E +LK + N+E +Q++ ++ + ++K +V+ L
Sbjct: 2130 ADEKKQLHIAEK--LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 938 VSQLRQTEEQVN-------DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
+Q+ + + L+ + T +++ Q ++ L++ L+ K + EE ++
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE-KEQA 2246
Query: 991 EVRLKESAEFQTQ-LEKKLMEVEKEKQELQDDK--------------------RRAIESM 1029
E+++KE ++ + L+ +L E+ + L D+ R +IE +
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ----EQAKIAVEAQN-KYER 1084
+L +K V +++E+ A + R+ + Q A+EA+N K E
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
Query: 1085 ELMLHAAD--VEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEV 1142
E + + ++L+ + V + S +++L QK + ++ E + E +L+++
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI-LR 1201
+ V E +L Q+++L+++V A + E K++EQ L +
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHND----------QEACKAKEQNLSSQVE 2476
Query: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
+ EK + A+ + + V L +E+++ + L + E++ + E+
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
Query: 1262 LMKKTETMN----VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEK 1317
L+ K + + E N LR LEQ +Q +Q+K L+ + LQ + L +
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENE 2596
Query: 1318 SGMLQAEKKLLEEDVKRWKARNQHLVSQ-----QKDPDTEEYRKLLSEKEVHTKRIQQLT 1372
+ + +K E V + A+ L + QK + +E +L EK +Q L
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE--ELSGEKNRLAGELQLLL 2654
Query: 1373 EEIGRLK---AEIARSNASLTNNQNLIQS--------LKEDLNKVRTEKETIQKDLDAKI 1421
EEI K E+ N+ L + + + ++E++ + + +K A +
Sbjct: 2655 EEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL 2714
Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKE 1481
+D ++ + +++ + ++ E L +Q+ ++ + + + Q ++ELK+
Sbjct: 2715 LDTNKQYEV--EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772
Query: 1482 T-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR------L 1528
T +NQ + +++ + +++ L K+ + E E LQ++ QLQ+ + +
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVM 2832
Query: 1529 RQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGAL 1588
+ + TT+ ++L++ + EK ++ + + K L ++L K E L+ + L
Sbjct: 2833 DTKVDELTTEIKELKETLEEKTKEADEYL----DKYCSLLISHEKLEKAKEMLETQVAHL 2888
Query: 1589 DQQKDELDVRITAL-----------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
Q+ + D R + L S E R+S + + ++R + + P+
Sbjct: 2889 CSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPA 2948
Query: 1638 VPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASI 1697
PE + + K + GI D +P + K A G K++P I
Sbjct: 2949 TPESFSKKSKKAVMS----GIHPAEDTEGTEFEPEGLPEVVKKGFADIPTG-KTSP--YI 3001
Query: 1698 RPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGP 1734
T AT T+P + + + +S P
Sbjct: 3002 LRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKP 3038
Score = 179 bits (455), Expect = 2e-44
Identities = 396/1835 (21%), Positives = 742/1835 (40%), Gaps = 265/1835 (14%)
Query: 26 EKFLADQQSEIDGLK---GRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLEL 82
+ F+A+ I L+ H+ E+ EK L +++ E E Q L+
Sbjct: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934
Query: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
L + LK L ++ L + + +I S R EEL E L N L+QE L
Sbjct: 935 HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
Query: 143 EDVKRLNEKLKESNTTKGEL-----QLKLDELQA--------SDVSVKYREKRLEQEK-E 188
+ + + E + EL Q KL LQ D+S KY+ + + K E
Sbjct: 995 QKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
Query: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE----EVSRLEEQMNGLK 244
L ++ T L K + ++L ++ E L E + + E+ +++ +
Sbjct: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114
Query: 245 TSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNEL 303
T N++ K L ++ KE+Q M+++ ++ L + +L + K+ + +S +
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI 1174
Query: 304 TRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSAT 363
+V+E E + N Q L E S D ++++ LE L N L +
Sbjct: 1175 RNSVKERE---SERNQCNFKPQMDLEVKEISLDSYNAQLVQ----LEAMLRNKELKLQES 1227
Query: 364 KRKGAILSEEELAAMSPTAAAVAKIVK----PGMKLTEL--YNAYVETQDQLLLEKLENK 417
+++ L E + + ++ G+K E+ Y+ +L + +N
Sbjct: 1228 EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNA 1287
Query: 418 RINKYLDEIVKEVEAKAPILK-RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
+ L + ++ I + Q E+YE V L+ + + +++ E+ K
Sbjct: 1288 HLQCSLQTTMNKLNELEKICEILQAEKYE----LVTELNDSRSECITATRKMAEEVGKLL 1343
Query: 477 KQSSVLERDNRRMEIQ-VKDL---------SQQIRVLLMELEEARG--NHVIRDEEVSS- 523
+ +L D+ + + V+D+ ++Q V L L+E+ + + D+EV
Sbjct: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMH 1403
Query: 524 --------ADISSSSEVI-SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
+ S +++ QH + ELQ L L T R Q
Sbjct: 1404 FAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVL-STNLRNFQ---GD 1459
Query: 575 KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV--------AI 626
+ E+QL LE L + L S + S+ YR LL QT + A+
Sbjct: 1460 LVKEMQLGLEEGL--VPSLSSSCVPDSSSLSSL-GDSSFYRALLEQTGDMSLLSNLEGAV 1516
Query: 627 PLHASSLDDVSLASTPKRPST-SQTVSTPAP-VPVIES------------TEAIEAKAAL 672
+ S+D+V +S + T +T S PA V +ES E +E++ +
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576
Query: 673 --KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQD 730
K++QE+ + E+ E + ++ + L + ++ L S ++ ++L K+ E L
Sbjct: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636
Query: 731 NVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD-LRGANEKLAVAEVRAENLKKEKE 789
+E R ++ L ++ L + T+D ++G NE ++ E+ + E
Sbjct: 1637 ELEVARLQLQGLDLSSRSL----------LGIDTEDAIQGRNES---CDISKEHTSETTE 1683
Query: 790 MLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE-- 847
+V +++ Q+ NL + + + E +Q + E +
Sbjct: 1684 RTPKHDVHQICDKDA----QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
Query: 848 ------ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL--------NTKEL 893
IS L N + L D+ L + + + NL L E
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVES 1799
Query: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
L N KE+ + K HL +++ ++ K K++ DL +L +L +
Sbjct: 1800 LLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
Query: 954 RLKTS---TSNVEQY--QAMVTSLEESLNKEKQVTEEVRKNIEVRL------KESAEFQT 1002
R++TS S++E + ++ + +++ K +E ++E L K S E +
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
Query: 1003 -QLEKKLMEVEKEKQELQDD---KRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
LE L V+ EK L+ D K++ I +E++LS + + ++ E+ + + + +TAL
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTAL 1977
Query: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV----EALQAAKEQVSKMASVRQHLE 1114
Q +E+ + Q++ + + A+V E LQ VS++ + HL+
Sbjct: 1978 ---DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034
Query: 1115 ETTQKAE--SQLLE-CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
E Q E SQ L K E + L E V E L Q RL EKL+
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL--QARLSESDYEKLNVSKA 2092
Query: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIR--REKEIAETRFEVAQVESLRYRQR-- 1227
+G + LS +QE++ ++ R I R + A+ + ++ E L+ R+R
Sbjct: 2093 LEAALVEKGEFALRLS---STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149
Query: 1228 ------VELLERELQELQDS-----LNAEREKVQV-TAKTMAQHEELMKKTETMNVVMET 1275
VE LERELQ +++ L+AE K +V T KT Q EE+ + + + + T
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT--QIEEMARSLKVFELDLVT 2207
Query: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPL-------QEANAELSEKS----GMLQAE 1324
LR EKE L + +Q+ Q ++ +L+ + ++A ++ E+S MLQ +
Sbjct: 2208 ---LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264
Query: 1325 KKLLEEDVKRWKARNQHL--VSQQKDPDTEEYRKL------------------------L 1358
K L E V + + Q DP EE +L L
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSN-----ASLTNNQNLIQSLK-------EDLNKV 1406
E E H ++ E + R + EIAR+N N++ +++LK + L +
Sbjct: 2325 KESEHHADLLKGRVENLER-ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383
Query: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH 1466
+ TI+ + + ++Q++ + I++++ I ++ +E + ++ ++ E S+ +
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 2443
Query: 1467 QEQHVSVQE-MQELKETLNQAETKSKSLESQVENLQ---KTLSEKETEARN----LQEQT 1518
Q Q + E + L + K ++L SQVE L+ L + EA+N LQ
Sbjct: 2444 QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503
Query: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
L E+ +Q L+ + + +L+ QI ++E+ SK++ + G + QL KE
Sbjct: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV--------SKLSQVEG-EHQLWKEQ 2554
Query: 1579 E--------ELKQRNGALDQQKDELDVRITALKSQYEGRISRLE----------RELREH 1620
EL+Q+ L + L + L+S Y+ + LE ++ +
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614
Query: 1621 QERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGE 1655
+ E + E E + K E Q +++ + +GE
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Score = 172 bits (437), Expect = 3e-42
Identities = 321/1469 (21%), Positives = 621/1469 (42%), Gaps = 220/1469 (14%)
Query: 5 LQQVLERTELNKLPKSVQ-NKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSH 63
L+++ E+ E + K+ + +LE+ L+ ++ E+D L+ +++ E+EQ ++
Sbjct: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR---KQYLSENEQWQQKLTSVTLE 1619
Query: 64 SQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL------EIAQDRNIAIQSQFTRTK 117
+ +L E ++ + L LELE QL+ L ++ L + Q RN + T
Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679
Query: 118 EELE-AEKRDLIRTNER-----LSQELEYLTED--VKRLNEKLKESNTTKGELQLKLDEL 169
E E K D+ + ++ L+ ++E +TE VK E E + D+
Sbjct: 1680 ETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKT 1739
Query: 170 QASDVSVK---YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Q S + + + L +Q N +L+ K E NE L L +
Sbjct: 1740 QGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK---------ETSNENLRLLHVI 1790
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLK----------EAKEQQASMEEKF- 275
E++ +V L +M L S HLQ+ L+TK++ E K++ + + EK
Sbjct: 1791 EDRDRKVESLLNEMKELD-SKLHLQE--VQLMTKIEACIELEKIVGELKKENSDLSEKLE 1847
Query: 276 -----HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA----IQD 326
H EL ++ S S D E +++ +R E++ + + ++ K +++
Sbjct: 1848 YFSCDHQELLQRVETSEGLNS---DLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVEN 1902
Query: 327 HLLEVEQSKDQMEKEML-----------EKIGRLEKELENANDLLSATKRKGAILSEE-- 373
L + K +E E L EK+ LEK+ EN ++ + + ++++ E
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLEVVQTEKLC-LEKDNENKQKVIVCLEEELSVVTSERN 1961
Query: 374 ----ELAAMSPTAAAVAKIV-KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVK 428
EL MS A+ ++ K K EL + E + + + E K + L +
Sbjct: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021
Query: 429 EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
+V +E+ + +K +LS+ + +I +L ++ + K+S L+
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQ- 547
+ + ++S+ + L+E +G +R +SS+ E + Q R IE+L+
Sbjct: 2082 SDYEKLNVSKALEAALVE----KGEFALR--------LSSTQEEVHQ---LRRGIEKLRV 2126
Query: 548 --QQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVD 605
+ +++ + + E + RERE ++ K+ L+ +L+ S ++Q ++
Sbjct: 2127 RIEADEKKQLHIAEKLKEREREN-DSLKDKVENLE----------RELQMSEENQELVIL 2175
Query: 606 SIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
+ L +Q +A L LD V+L S K T Q
Sbjct: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE-KENLTKQIQ-------------- 2220
Query: 666 IEAKAALKQLQEIFENYKK--EKAENEKIQNEQ-----LEKLQEQVTDLRSQNTKISTQL 718
E + L +L ++ ++K E+ E +IQ ++ +E LQ Q+ +L +
Sbjct: 2221 -EKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279
Query: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
+ + L +E + S+ + +L A +KQ ++ Q L+ + + +
Sbjct: 2280 EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL----QQLKESEHHADLLK 2335
Query: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQ-RGQNLLLTNLQTIQGILERSETETKQRL 837
R ENL++E E+ R +Q+ +L AE +G+ ++T++ +E T++ + L
Sbjct: 2336 GRVENLERELEI-----ARTNQEHAALEAENSKGE------VETLKAKIE-GMTQSLRGL 2383
Query: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
+ + E K+ L NE+++ L++ +++ L KE K
Sbjct: 2384 ELDVVTIRSE----KENLTNELQKEQERISELEI--------INSSFENILQEKEQEKVQ 2431
Query: 898 QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
KE ++ + +++ ++ Q + K +L SQ+ E + L + L
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQ- 1016
+ +N Q+ V L + + KQ E+ + I RLK + Q QL KL +VE E Q
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS-RLKNQIQDQEQLVSKLSQVEGEHQL 2550
Query: 1017 --ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
E + R +EQ++ L+ +S+Q+ + E LQ + L NE + +
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTL-EVLQSSYKNLENELELTK-------- 2601
Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL--EETTQKAESQLL--ECKAS 1130
++ + E+ + A + E + E K A +++ L E+ E QLL E K+S
Sbjct: 2602 -MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
Query: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLH-DQIEKLSDKVVASVKEGVQGPLNVSLSE- 1188
KD++ + +L+K +H DQ+EK KV + E + L E
Sbjct: 2661 --------KDQLKELTLENSELKKSLDCMHKDQVEK-EGKVREEIAE-----YQLRLHEA 2706
Query: 1189 EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVE--LLERELQELQDSLNAER 1246
E K Q +L+ + + E EI R ++ E Q++E LL+ +EL +SL A
Sbjct: 2707 EKKHQALLLDTNK--QYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATT 2764
Query: 1247 EKVQVTAKTMAQH----EELMKKTET----MNVVMETNKMLREEKERLEQDLQQMQAKVR 1298
+ ++ KT + +L K+ E M +++++ K L EEKE L+++L Q+QA
Sbjct: 2765 QILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824
Query: 1299 KLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLL 1358
K Q+ + K L E K L+E ++ +++ D ++Y LL
Sbjct: 2825 K--------QKTGTVMDTKVDELTTEIKELKETLEE--------KTKEADEYLDKYCSLL 2868
Query: 1359 SEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
E K + L ++ L ++ ++ ++
Sbjct: 2869 ISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
Score = 160 bits (405), Expect = 1e-38
Identities = 327/1585 (20%), Positives = 651/1585 (41%), Gaps = 257/1585 (16%)
Query: 35 EIDGLKGRHEKFKVESEQQYFEI---EKRLSHSQERLVNETRECQSLRLELEKLNNQLKA 91
+I L+G+ +K K E +Q+ F++ E L ++++ NE E +L+ E ++L
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL------ 72
Query: 92 LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEK 151
+EI + +TK+++ E + ++ ++ QE + L K++ +
Sbjct: 73 -------MEICES--------LEKTKQKISHELQ--VKESQVNFQEGQ-LNSGKKQIEKL 114
Query: 152 LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLAL 211
+E K EL+ Q++DVS+ NT K T L
Sbjct: 115 EQELKRCKSELERSQQAAQSADVSLNP------------------CNTPQKIFTTPLTPS 156
Query: 212 GREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQAS- 270
G++ +LK + EE RLE ++ L+ + + Q + + A+ Q +S
Sbjct: 157 QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ-AKKASQTLPQATMNHRDIARHQASSS 215
Query: 271 ----MEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT--RAVEELHKLLKEAGEANKAI 324
+EK + L+++ + + + + + + E+T R+ ++ K + + +
Sbjct: 216 VFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSS 275
Query: 325 QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAA 384
HLL+ ++++Q E+ KI LE L+ + KG + +EL
Sbjct: 276 SPHLLDQLKAQNQ---ELRNKINELELRLQG-----HEKEMKGQVNKFQELQ-------- 319
Query: 385 VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY 444
++ K ++L E + +D+L+ R D+ + A LK+ E+
Sbjct: 320 -LQLEKAKVELIEKEKVLNKCRDELV-------RTTAQYDQASTKYTALEQKLKKLTEDL 371
Query: 445 ERAQKAVASLSVKLEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVL 503
++ S LEQ +KE ++ QE+ + + L+++ +M+ + L
Sbjct: 372 SCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR----------L 421
Query: 504 LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGET 563
EL++A+ H + E +++L Q+L L E +
Sbjct: 422 TQELQQAKNMHNVLQAE----------------------LDKLTSVKQQLENNLEEFKQK 459
Query: 564 REREEQETTSSKITELQLK--LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
R EQ +S+I E +L+ +E E L+ + + + V + + + L+Q+
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519
Query: 622 TGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFEN 681
+ A K +TSQ + L+ LQE
Sbjct: 520 Q--------------NFAEEMKAKNTSQ-------------------ETMLRDLQE---- 542
Query: 682 YKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITS 741
K + EN + LEKL+ V DL Q L E L D + +E +
Sbjct: 543 -KINQQEN----SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597
Query: 742 LHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV-AEVRAENLKKE----KEMLKLSEV 796
L +L ++ + T+ + NEKL E ENL+ + + LK ++
Sbjct: 598 LLSA-LELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
+ + E + + + L ++ + +L+ E + + + +E L+ + +K +
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME-LQQKAEFSDQKHQ 715
Query: 857 NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
E+E T L Q+ D + +L +N ++ ++ E +L+ L + + +
Sbjct: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
Query: 917 S----QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSL 972
+ Q S QP+ +++ + + ++ + S N Q V SL
Sbjct: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 973 EESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQ 1032
E SL +KQ+ +++K E E + + ++E+ LM+ E+ Q + + I +++
Sbjct: 836 EFSLESQKQMNSDLQKQCE----ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED 891
Query: 1033 LSE----LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELML 1088
S + +TLS+++N+ +E LQ + + EQ ++ ++ + ++ +EL L
Sbjct: 892 TSAHQNVVAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQL 946
Query: 1089 HAADVEALQAAKEQVSKMASV-RQHLEETTQKAESQLLECKASWEERERML--------- 1138
+ E L K+++S + S+ ++ +EE TQ+ L E AS + + L
Sbjct: 947 LS---ETLSLEKKEMSSIISLNKREIEELTQE-NGTLKEINASLNQEKMNLIQKSESFAN 1002
Query: 1139 -KDEVSKCVCRCEDLEKQNRLL--------HDQIEKLSDKVVASVKEG--VQGPLN--VS 1185
DE K + D KQ +L+ + E LS K A+ ++ ++ LN S
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
Query: 1186 LSEEGKSQ-EQILEILRFIRREKE------IAETRFE--VAQVESLRYRQRVELLERE-- 1234
L E K++ EQ+ E F + +E AE R + + ++E+++ R E+ + +
Sbjct: 1063 LCENRKNELEQLKE--AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120
Query: 1235 -------LQELQDSLNAEREKVQVTAKTMAQ-HEELMK----KTETMNVVME--TNKMLR 1280
L++ +L E+ K+Q + Q +E+LMK K E N+ E N +
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 1281 EEKERLEQDLQ-QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARN 1339
E ER + + + QM +V+++ LD NA+L + ML+ ++ L+E K +
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLD-----SYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
Query: 1340 QHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
L + + D +T + + S++ K + EE + + + S +N +L SL
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE--KYISGPHELSTSQNDNAHLQCSL 1293
Query: 1400 KEDLNKVRTEKETIQKDLDAKIIDI-----QEKVKTITQVKKIGRRYKTQYEELKAQQDK 1454
+ +NK+ E E I + L A+ ++ + + IT +K+ E+K D
Sbjct: 1294 QTTMNKL-NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
Query: 1455 --------VMETSAQSSGDH-QEQH-VSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
V + G+ EQH VS+ + E + K ++ LQ+
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE-SNSYEHLTLSDKEVQMHFAELQEKF 1411
Query: 1505 SEKETEARNLQEQTVQLQSELSRLR 1529
++E + L +Q Q+ S++S L+
Sbjct: 1412 LSLQSEHKILHDQHCQMSSKMSELQ 1436
Score = 155 bits (392), Expect = 4e-37
Identities = 379/1823 (20%), Positives = 730/1823 (40%), Gaps = 349/1823 (19%)
Query: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
R ++N+L +Q EK + Q ++ L+ + EK KVE E EK L+ ++ LV
Sbjct: 291 RNKINELELRLQGH-EKEMKGQVNKFQELQLQLEKAKVE----LIEKEKVLNKCRDELVR 345
Query: 71 ETRECQSLRLELEKLNNQLKALTE----KNKELEIAQ--------DRNIAIQSQFTRTKE 118
T + + L +LK LTE + + E A+ ++ Q + +R +
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 119 ELEAEKRDLIRTNERLSQELEY---------------------LTEDVKRLNEKLKESNT 157
+ ++ I+ RL+QEL+ L +++ +KL +
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
Query: 158 TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELK--------------- 202
Q+K +EL+ S +K L+ E + L ELK
Sbjct: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
Query: 203 -----TKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL 257
T + +L +EK N+ E LE K V+ LE+Q + + + + H+E L
Sbjct: 526 MKAKNTSQETMLRDLQEKINQ-QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 258 LTKL-KEAKEQQA-----SMEEKFHNELNAHIKLSNLYKSAAD----DSEAKSNELTRAV 307
KL K KE +A +++K + EL L + +KS + E++ L +
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI 644
Query: 308 EELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
L LK + I+ H +M++E L E+ N +++L + K
Sbjct: 645 NHLETCLK-----TQQIKSHEYNERVRTLEMDRE------NLSVEIRNLHNVLDS---KS 690
Query: 368 AILSEEELAAMSPTAAA-------VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
+ ++LA M A +I +K ++L + + +L L E +
Sbjct: 691 VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750
Query: 421 KYLDEIVKEVEAKAPILKRQ------REEYERA----------QKAVASLSVKLEQAMKE 464
+ ++ E E+ +LK + E+++R+ + A++ + E
Sbjct: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 465 IQRLQEDTDKANKQSSVLERDNRRMEIQV---KDLSQQIRVLLMELEEARG---NHVIRD 518
+ + D++ K S++L+ +E + K ++ ++ EL + +G ++++
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
Query: 519 EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578
E++ + ++ +S+ IS+ ++E +Q ++ E +E+E Q
Sbjct: 871 EQMHQSFVAETSQRISK-------LQEDTSAHQNVVAETLSALENKEKELQ--------L 915
Query: 579 LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL 638
L K+E+ E+++L+KS L DS+ + LLS+T L + S+
Sbjct: 916 LNDKVETEQAEIQELKKSNH---LLEDSLKELQ-----LLSET------LSLEKKEMSSI 961
Query: 639 ASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLE 698
S KR T + S + K L Q E F NY E+ E
Sbjct: 962 ISLNKREIEELTQENGTLKEINASLN--QEKMNLIQKSESFANYIDER-----------E 1008
Query: 699 KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
K +++D Q I Q R E + E ++ + E+N KL E
Sbjct: 1009 KSISELSDQYKQEKLILLQ------RCEETGNAYEDLSQKYKAAQEKNSKL-------EC 1055
Query: 759 IINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQ--RESLLAEQRGQNLLL 816
++N T EN K E E LK + + Q+ + AE+R QNL+L
Sbjct: 1056 LLNECTS--------------LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
Query: 817 TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK---KLENEVEQRHTLTRNLDVQL 873
L+T+Q L T+ + S+ L+ EI LK+ K++ EV L +++
Sbjct: 1102 -ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-MKV 1159
Query: 874 LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTG----KGQPS 929
+ TK + + + + +++ K + ++EV+ S S +
Sbjct: 1160 MKTKHECQNLESEPIRNSVKERESERNQCNFKPQM-DLEVKEISLDSYNAQLVQLEAMLR 1218
Query: 930 NKEDVDDLVSQLRQTEEQVNDLKERLKT-----STSNVEQYQAM-VTSLEE--------- 974
NKE +L+++E++ L+ L+T TSN++ Q+ ++ L++
Sbjct: 1219 NKE------LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKY 1272
Query: 975 -SLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK--KLMEVEKEK--QELQDDKRRAIESM 1029
S E ++ +++ L+ + +LEK ++++ EK + EL D + I +
Sbjct: 1273 ISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT 1332
Query: 1030 EQQLSELKKTLSSVQ--NEVQEAL--QRASTALSNEQQARRDCQEQAKIA-VEAQNKYE- 1083
+ E+ K L+ V+ N+ L + E + + Q +A ++ N YE
Sbjct: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
Query: 1084 -----RELMLHAADVE----ALQAAK--------EQVSKMASVRQHLEETTQKAESQLLE 1126
+E+ +H A+++ +LQ+ + SKM+ ++ +++ + KAE+ +L
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD--SLKAENLVLS 1450
Query: 1127 C-----------KASWEERERMLKDEVSKCVCRCEDLEK--QNRLLHDQIEKLSDKVVAS 1173
+ E ++ S CV L + +E+ D + S
Sbjct: 1451 TNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
Query: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESL--RYRQRVELL 1231
EG S+ E S L+ R+E A + V ++ESL YRQ +E L
Sbjct: 1511 NLEGAVSANQCSVDEVFCSS---LQEENLTRKETPSAPAK-GVEELESLCEVYRQSLEKL 1566
Query: 1232 E-----------RELQELQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKML 1279
E +E+QEL+ L++ER+++ K ++++E+ +K ++ + ME +K+
Sbjct: 1567 EEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEME-SKLA 1625
Query: 1280 REEK--ERLEQDLQQMQAKVRKLELDILPLQEANAE--LSEKSGMLQAEKKLLEEDVKRW 1335
E+K E+L +L+ + +++ L+L L + E + ++ K+ E +R
Sbjct: 1626 AEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTER- 1684
Query: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK---------------- 1379
+H V Q D D ++ L EK T ++ E G
Sbjct: 1685 --TPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
Query: 1380 ----AEIARSNASL----------------------TNNQNL-IQSLKEDLNKVRTEKET 1412
+E++ S + T+N+NL + + ED ++
Sbjct: 1743 SECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802
Query: 1413 IQKDLDAKI----IDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
K+LD+K+ + + K++ +++KI ELK + + E S DHQE
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKI-------VGELKKENSDLSEKLEYFSCDHQE 1855
Query: 1469 QHVSVQEMQELKETLNQAETKSKSLESQVENLQKT-------LSEKETEARNLQEQTVQL 1521
V+ + L L KS S E +N+ K + E E ++ + +
Sbjct: 1856 LLQRVETSEGLNSDLEMHADKS-SREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
Query: 1522 QSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
+ E L DL+ Q E+L + + E +K IV + +++ + ++QL E + +
Sbjct: 1915 EHEALYLEADLE--VVQTEKL--CLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 1582 KQRNGALDQQKDELDVRITALKS 1604
++ ALDQ +++ + L+S
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELES 1993
Score = 150 bits (380), Expect = 1e-35
Identities = 284/1397 (20%), Positives = 565/1397 (40%), Gaps = 196/1397 (14%)
Query: 331 VEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAV----- 385
+E+ K+ + L+KI LE +L D L K++ + AA+ V
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQL----DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60
Query: 386 --AKIVKPGMKLTELYNAYVETQDQLLLE-KLENKRIN---KYLDEIVKEVEAKAPILKR 439
+ + +L E+ + +T+ ++ E +++ ++N L+ K++E LKR
Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
Query: 440 QREEYERAQKAVASLSVKLE-----QAMKEIQRLQEDTDKANKQSSVLERDN------RR 488
+ E ER+Q+A S V L Q + +K + E+ N +R
Sbjct: 121 CKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
Query: 489 MEIQVKDLSQQIRVLLMELEEARGNH-VIRDEEVSSADISSSSEVISQHLVS-------- 539
+E +VK L Q + L +A NH I + SS+ S E HL S
Sbjct: 181 LEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIR 238
Query: 540 -------YRNIEELQQQNQRLLVALRELGET------------REREEQETTSSKITELQ 580
+ +E+ L + R+ + + + + + +KI EL+
Sbjct: 239 RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 581 LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
L+L+ E++ Q+ K ++ Q+QL + V + ++L + D +
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-------------NKCRDELVR 345
Query: 640 STPK--RPSTSQTVSTPAPVPVIE--STEAIEAKAALKQLQEIFENYKKEKAENEKIQNE 695
+T + + ST T + E S + A++A L++ + +KE E Q
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 696 QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQK 755
+ L ++ +++ +++ +L A + +LQ ++ KLT+ Q+
Sbjct: 406 SFQTLDQECIQMKA---RLTQELQQAKNMHNVLQAELD--------------KLTSVKQQ 448
Query: 756 QEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLL 815
E + Q L A + ++++ L++ E +K L E E
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 816 LTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD 875
L N++ + E K + +SQ E + L++K+ N+ E TL + L + + D
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQ----ETMLRDLQEKI-NQQENSLTLEK-LKLAVAD 562
Query: 876 TKRQLDTETNL---------HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRT--G 924
++Q D +L LN K L +KE L L + + ++T
Sbjct: 563 LEKQRDCSQDLLKKREHHIEQLNDK--LSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
Query: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE 984
+ N++ + + S+ + ++N L+ LKT +Y V +LE + ++
Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD---RENLSV 677
Query: 985 EVRKNIEVRLKESAEFQTQLEKKLMEVE-KEKQELQDDK-RRAIESM-------EQQLSE 1035
E+R V +S E +TQ KL +E ++K E D K ++ IE+M Q+ +
Sbjct: 678 EIRNLHNVLDSKSVEVETQ---KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVED 734
Query: 1036 LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM-------L 1088
L+ L + NE+ + R L E ++ RD + ++ ++R L+ +
Sbjct: 735 LEHKLQLLSNEIMDK-DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 1089 HAADVEALQAAKEQVSKMASVRQHLEETTQKA---ESQLLECKASWEERERMLKDEVSKC 1145
H + + S+ + R +++ + + ++++ + S E +++M D
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK-- 851
Query: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ-----ILEIL 1200
+CE+L + + + + K + V E Q +S +E S Q L L
Sbjct: 852 --QCEELVQIKGEIEENLMKAEQMHQSFVAETSQ---RISKLQEDTSAHQNVVAETLSAL 906
Query: 1201 RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ-DSLNAEREKVQVTAKTMAQH 1259
+E ++ + E Q E ++ LLE L+ELQ S EK ++++
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 1260 EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE---------- 1309
E+ + T+ + E N L +EK L Q + + + E I L +
Sbjct: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1310 --------ANAELSEKSGMLQAEKK----LLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
A +LS+K Q + LL E + R L Q K+ +E+++
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL-EQLKEAFAKEHQEF 1085
Query: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS----LKEDLNKVRTEKETI 1413
L++ +R Q L E+ ++ + + +T+NQN +S LK+++ ++ E+ +
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQAL---RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1142
Query: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
QK+++ + + ++ +K + KT++E + + + + + + + +
Sbjct: 1143 QKEVNDLLQENEQLMKVM----------KTKHECQNLESEPIRNSVKERESERNQCNFKP 1192
Query: 1474 QEMQELKE-TLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDL 1532
Q E+KE +L+ + LE+ + N + L E E E LQ + ++ +L +L
Sbjct: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLE--TSNL 1250
Query: 1533 QDRTTQE-EQLRQQITEKEEKTRKA---IVAAKSKIAHLAGVKDQLTKENEELKQRNGAL 1588
QD +QE L+ + EEK + +++ AHL + EL++ L
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
Query: 1589 DQQKDELDVRITALKSQ 1605
+K EL + +S+
Sbjct: 1311 QAEKYELVTELNDSRSE 1327
Score = 149 bits (375), Expect = 4e-35
Identities = 333/1682 (19%), Positives = 661/1682 (39%), Gaps = 279/1682 (16%)
Query: 36 IDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEK 95
+D LK ++++ + + E+E RL ++ + + + Q L+L+LEK +L EK
Sbjct: 280 LDQLKAQNQELR----NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL---IEK 332
Query: 96 NKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKES 155
K L +D + +Q+ + + A L Q+L+ LTED+ + + +
Sbjct: 333 EKVLNKCRDELVRTTAQYDQASTKYTA-----------LEQKLKKLTEDLSCQRQNAESA 381
Query: 156 NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215
+ + K +EK E ++EL Q ++ +T E + +
Sbjct: 382 RCS---------------LEQKIKEKEKEFQEELSRQQRSF-----QTLDQECIQMKARL 421
Query: 216 GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ-QASM--E 272
E+ + K N+ N L+ +++ L + + L+ ++E+ KL A++ QAS E
Sbjct: 422 TQELQQAK-NMHNV------LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Query: 273 EKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
+ + K +NL KS SE K+ E+ EL K +K+ ++ + +
Sbjct: 475 NELRRSMEEMKKENNLLKS---HSEQKAREVCHLEAEL-KNIKQCLNQSQNFAEEMKAKN 530
Query: 333 QSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
S++ M +++ EKI + E L + K K A+ E+ S
Sbjct: 531 TSQETMLRDLQEKINQQENSL-------TLEKLKLAVADLEKQRDCS------------- 570
Query: 393 MKLTELYNAYVETQDQLLLEKLEN--KRINKYLDEIVKEVEAKAPILKRQREEYERAQKA 450
Q LL+K E+ +++N L + KE +A L+ +++EYE ++
Sbjct: 571 ---------------QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 451 VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE-- 508
S + K + +++ + + + + LE + +I+ + ++++R L M+ E
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 509 --EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRER 566
E R H + D S S EV +Q L ELQQ+ E + + +
Sbjct: 676 SVEIRNLHNVLD--------SKSVEVETQKLA----YMELQQK--------AEFSDQKHQ 715
Query: 567 EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD-MYRILLSQTTGVA 625
+E E K ++L ++E +H++QL+ + + +D Y+ L ++ +
Sbjct: 716 KEIENMCLKTSQLTGQVEDL-----------EHKLQLLSNEIMDKDRCYQDLHAEYESLR 764
Query: 626 IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
L + D SL T + S P I + ++ + +
Sbjct: 765 DLLKSK---DASLV-TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 686 KAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER 745
+N I +++ L+ + + N+ + Q + E++Q E + +
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE------ELVQIKGE-IEENLMKAEQM 873
Query: 746 NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL 805
+Q A T Q I+ + +D + + VAE + KEKE+ L++ ++ ++ +
Sbjct: 874 HQSFVAET---SQRISKLQEDT--SAHQNVVAETLSALENKEKELQLLND-KVETEQAEI 927
Query: 806 LAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTL 865
++ +LL +L+ +Q + E E K+ S I L K+ E+ Q +
Sbjct: 928 QELKKSNHLLEDSLKELQLLSETLSLEKKEMSS---------IISLNKREIEELTQENGT 978
Query: 866 TRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
+ ++ L K L ++ N + +K I+ L E + Q + TG
Sbjct: 979 LKEINASLNQEKMNLIQKSESFAN---YIDEREKSISELSDQY-KQEKLILLQRCEETGN 1034
Query: 926 GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
+DL + + +E+ + L+ L TS E + + L+E+ KE Q E
Sbjct: 1035 A-------YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ---E 1084
Query: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN 1045
+ + + +LE + E + Q++ + ++Q++ LK+ + +Q
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
Query: 1046 EVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK 1105
EV + LQ + L + + +CQ + K ERE + + + + +
Sbjct: 1145 EVNDLLQE-NEQLMKVMKTKHECQNLESEPIRNSVK-ERESERNQCNFKPQMDLEVKEIS 1202
Query: 1106 MASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQN--RLLHDQI 1163
+ S L + ++ L+ + S +E+E L+ E+ DLE N + +I
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELKLQESEKEKE-CLQHELQTI---RGDLETSNLQDMQSQEI 1258
Query: 1164 EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLR 1223
L D + + ++ + GP +S S+ + Q + T ++ ++E +
Sbjct: 1259 SGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC-----------SLQTTMNKLNELEKI- 1306
Query: 1224 YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK 1283
E+L+ E EL LN R + + MA EE+ K + ++ + + +L E
Sbjct: 1307 ----CEILQAEKYELVTELNDSRSECITATRKMA--EEVGKLLNEVKILNDDSGLLHGE- 1359
Query: 1284 ERLEQDLQQMQAKVRKLE---LDILPLQEAN----------------AELSEKSGMLQAE 1324
L +D+ + + E + + PL E+N AEL EK LQ+E
Sbjct: 1360 --LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417
Query: 1325 KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
K+L + QH K + + Y + LKAE
Sbjct: 1418 HKILHD---------QHCQMSSKMSELQTY--------------------VDSLKAENLV 1448
Query: 1385 SNASLTNNQ-NLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKT 1443
+ +L N Q +L++ ++ L +E + L + + + ++ Y+
Sbjct: 1449 LSTNLRNFQGDLVKEMQLGL------EEGLVPSLSSSCVPDSSSLSSLGD----SSFYRA 1498
Query: 1444 QYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS------KSLESQV 1497
E+ A S+ V +QE E L + ET S + LES
Sbjct: 1499 LLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQE--ENLTRKETPSAPAKGVEELESLC 1556
Query: 1498 ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI 1557
E +++L + E ++ Q + E+ L Q L + + LR+Q + E+ ++ +
Sbjct: 1557 EVYRQSLEKLE---EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKL 1613
Query: 1558 VAA----KSKIAHLAGVKDQLTKENEELKQRNGALD---------QQKDELDVRITALKS 1604
+ +SK+A +QL+ E E + + LD +D + R +
Sbjct: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDI 1673
Query: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTT-PASGERGIASTSD 1663
E ER +H + +D Q+ + + + +K T SGE+ + +
Sbjct: 1674 SKEHTSETTER-TPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYE 1732
Query: 1664 PP 1665
PP
Sbjct: 1733 PP 1734
Score = 139 bits (351), Expect = 3e-32
Identities = 207/1038 (19%), Positives = 439/1038 (42%), Gaps = 137/1038 (13%)
Query: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
+++++L+ Q+ L+ + + QLD + + VE + E T+L NQ+L +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
E+ ++ +L+ ++ E + + KK+ E L+ R + E + ++
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
L T Q I T ++ S+ E LK+K EVE+R L +V+ L
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYE-------DLKEKYNKEVEERKRL--EAEVKAL 188
Query: 875 DTKRQLDTETNLHLNTKELLKN-AQKEIATLKQHLSNMEVQVASQSSQRT------GKGQ 927
K+ T +N +++ ++ A + + +Q + + S +SQRT
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHL---SSNSQRTPIRRDFSASY 245
Query: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
S +++V S L+ + N +S ++Q +A L +N+ + +
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHE 305
Query: 988 KNIEVRLKESAEFQTQLEKKLME-VEKEK------QEL------QDDKRRAIESMEQQLS 1034
K ++ ++ + E Q QLEK +E +EKEK EL D ++EQ+L
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 1035 ELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVE 1094
+L + LS + + A R S +++ + +E ++ Q + + + A +
Sbjct: 366 KLTEDLSCQRQNAESA--RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
Query: 1095 ALQAAKE-------QVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
LQ AK ++ K+ SV+Q LE ++ + +L + ++ + ++ ++E+ + +
Sbjct: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF-QASQIKENELRRSM- 481
Query: 1148 RCEDLEKQNRLLHDQIEKLSDKV------VASVKEGVQGPLNVS--LSEEGKSQEQILEI 1199
E+++K+N LL E+ + +V + ++K+ + N + + + SQE +L
Sbjct: 482 --EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
Query: 1200 L--RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
L + ++E + + ++A + + R + L ++ + + LN + K + +K +
Sbjct: 540 LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
Query: 1258 QHEELMKKT-ETMNVVMETNKMLREEKERL----EQDLQQMQAKVRKLELDILPLQEANA 1312
EL KK E + + E E+L E + + +Q+K+ LE + Q +
Sbjct: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
Query: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE----EYRKLLSEKEV----H 1364
E +E+ L+ +++ L ++ RN H V K + E Y +L + E H
Sbjct: 660 EYNERVRTLEMDRENLSVEI-----RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
Query: 1365 TKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ---KDLDAKI 1421
K I+ + + +L ++ L N I + E E+++ K DA +
Sbjct: 715 QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Query: 1422 IDIQEKVKTITQVKK-----------IGRR--YKTQYEELKAQQDK-------------- 1454
+ ++ +++ + IG + ++ E + + D+
Sbjct: 775 VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834
Query: 1455 ---VMETSAQSSGDHQEQ-HVSVQEMQELKETLNQAETKSKSL----ESQVENLQK---- 1502
+E+ Q + D Q+Q VQ E++E L +AE +S ++ LQ+
Sbjct: 835 LEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSA 894
Query: 1503 ----------TLSEKETEARNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKE 1550
L KE E + L ++ Q+E+ L++ L + + +E QL + E
Sbjct: 895 HQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLE 954
Query: 1551 EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI 1610
+K +I++ + ++LT+EN LK+ N +L+Q+K + + + I
Sbjct: 955 KKEMSSIISLNKREI------EELTQENGTLKEINASLNQEK----MNLIQKSESFANYI 1004
Query: 1611 SRLERELREHQERHLEQR 1628
E+ + E +++ +++
Sbjct: 1005 DEREKSISELSDQYKQEK 1022
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 183 bits (464), Expect = 2e-45
Identities = 370/1842 (20%), Positives = 769/1842 (41%), Gaps = 315/1842 (17%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61
LQ+ ++ E+ + K V+N ++ + ++++ I+ L + EK +E + + +K L
Sbjct: 301 LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
Query: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRN----------- 106
QE++V + +E ++++LEL + + +E+ K+L E Q RN
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
Query: 107 IAIQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
++ + R E+L AE K++LIR + ++Q E T + L+
Sbjct: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477
Query: 155 -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
SN T E Q+KL + +++++K ++ ++EK L EL +E AL R
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528
Query: 214 EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
+ + + EL + E + + EQ + L +++ L VEDL ++ A E + +E
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587
Query: 274 KFHNEL-NAHIKLSNL--YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326
K E+ N IKL L K+A D A+S E L E +K +D
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
H + +E+ KD + ++I L+ E+ + + K + + +S
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700
Query: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
KL +L + V + +++ + ++E+ KE+E IL+++ +E
Sbjct: 701 -------KLKDLQQSLVNS---------KSEEMTLQINELQKEIE----ILRQEEKEKGT 740
Query: 447 AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499
++ V L +K LE+ MKE + LQE + ++S+L+ + + +E +K +SQ+
Sbjct: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800
Query: 500 IRVLLMELEEARGNHVIRDEEV-----SSADISSSSEVISQHLVSYR------------N 542
R++ ++ +++ + ++E+ + D+ +++ + R N
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 543 IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
+ELQ++ LL +L +++ ++E E S +LK AL E L++ ++
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKS------KLK---ALNEELHLQRINPTTVK 911
Query: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
+ S+ D + + G + + L + + ++ SQ +S +
Sbjct: 912 MKSSVF-DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962
Query: 663 TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719
+E ++ K + L E ++ K+EK E ++ +LE + + +++S +T++S+ LD
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 720 FASKRYEMLQDNVEGYRREITSLHERNQKL------------TATTQKQEQIINTMTQDL 767
M EG ++ K+ KQEQ+I +
Sbjct: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
Query: 768 RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825
+ A + L+KE +LK ++ L + Q + L+ + + + +
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLK-------SEQNDLRLQMEAQRICLSLVYSTHVDQV 1131
Query: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
E E E + L S L+ E+ +++ E+++ H L++Q + T+ D
Sbjct: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183
Query: 886 LHLNTKELLKNAQKEIATLKQHLSN---------MEVQVASQSSQRTGKGQPSNKEDVDD 936
LHL +L K +E + Q L + ++ +V ++ + +G N++
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED---- 1239
Query: 937 LVSQLRQTEEQVNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESL 976
+L+ +V D +E + T + V E+Y ++ T L EE+L
Sbjct: 1240 --PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL 1297
Query: 977 NKEK--------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRA 1025
KE+ Q+T E++ N + +L + + T+LE+++ E+E LQ +
Sbjct: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKET 1357
Query: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR------------------- 1066
++ E ++ L+K L +V + + E A+R
Sbjct: 1358 EQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS 1417
Query: 1067 ---DCQEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEET-TQKAE 1121
+E+ I + +Y+ +L A V ++ A Q ++++ + E T + K
Sbjct: 1418 GEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQA 1477
Query: 1122 SQLLECKASWEERERMLKDEVSKCVCRCEDL--EKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
+ + + + ++ +D++ D+ +++ + L ++ + +++ S +
Sbjct: 1478 HAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHD 1537
Query: 1180 GPLN----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR------ 1223
P + +++SEE S+++ + + I E ++ + Q+E +R
Sbjct: 1538 IPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQ 1597
Query: 1224 ---YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
++Q ELL + + ++E++Q K + + + N+V E ++L
Sbjct: 1598 YQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLL 1657
Query: 1281 EEKERLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKA 1337
EE E L+Q L + +L Q N E EK+L EDV
Sbjct: 1658 EELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL 1717
Query: 1338 RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTN 1391
N+ Q+ + K+L E T ++ E IGR ++ ++S+ASL
Sbjct: 1718 SNERYALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIW 1771
Query: 1392 NQNLIQSLKEDLNK--VRTEKETIQ----KDLDAKIIDIQEKV--------KTITQVKKI 1437
S+K +++ R E+I D+ I++ KV + + +
Sbjct: 1772 RSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFA 1831
Query: 1438 GRRYKTQYEE--------LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETK 1489
G + EE L+A +K++E +++S Q +H V + + ++E+ Q +
Sbjct: 1832 GTEIDPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEA 1889
Query: 1490 SKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK 1549
++SL+ Q E L++ L E E+ AR QL ELS+ + ++ +QI EK
Sbjct: 1890 TESLKCQ-EELRERLHE-ESRARE------QLAVELSKAEGVIDGYADEKTLFERQIQEK 1941
Query: 1550 E---EKTRKAIVAAKSKIAHLAGVKDQ-------LTKENEELKQRNGALDQQ-------- 1591
++ + ++ A +++ L + Q L+++ E +K G ++QQ
Sbjct: 1942 TDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKL 2001
Query: 1592 -KDELDVRITA--LKSQYEGRISRLERELREHQERHLEQRDE 1630
K++L+V+ A ++ + ++ LE ++ E R +E E
Sbjct: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE 2043
Score = 150 bits (380), Expect = 1e-35
Identities = 332/1711 (19%), Positives = 678/1711 (39%), Gaps = 248/1711 (14%)
Query: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108
E E+Q F+ EK L E + E + R L+K NN+L + + + A + I
Sbjct: 1694 EVEEQTFK-EKELDRKPEDVPPEILSNE--RYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 109 IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE 168
+ LI +E + + E+ R+ ++ S + +
Sbjct: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGS--------D 1802
Query: 169 LQASDVSV--KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
+ +D+++ K E+ E + L+ S + TE+ + +EL+ N L+ +
Sbjct: 1803 MPRNDINMWSKVTEEGTELSQRLVRSG--FAGTEIDPENEELML------NISSRLQAAV 1854
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS 286
E E +S Q+ K + L + + E+ + Q + E+ H E A +L+
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
Query: 287 NLYKSA-------ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME 339
A AD+ ++ + + +L +E A+ +Q+ LE EQ + Q E
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE--LEAEQQQIQEE 1972
Query: 340 KEMLEK--------IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
+E+L + G +E++L + L K + +E+ + A+ V+
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
Query: 392 GM---------KLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQRE 442
+ K TEL + + Q+Q L ++LE R K+LDE + E + + +++ +
Sbjct: 2033 QVSRFIELEQEKNTELMD--LRQQNQALEKQLEKMR--KFLDEQAIDREHERDVFQQEIQ 2088
Query: 443 EYERAQKAVASLSVKLEQAMKEIQRL----QEDTDKANK--------QSSVLERDNR--R 488
+ E+ K V E +E+++L +E TDK ++ Q + ER+ +
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148
Query: 489 MEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ 548
+E +V++L Q LL+E + G + E + + + I + N+EE +
Sbjct: 2149 LEFRVRELEQ---ALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205
Query: 549 QNQRLLVALRELGETREREEQETTSSKITELQLKLE-------SALTELEQLRKSRQHQM 601
Q REE E + ++ +L ++LE + L ELEQ K + M
Sbjct: 2206 QF---------------REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2250
Query: 602 QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS---QTVSTPAPVP 658
+ + +++ D + +Q V A + + + + Q +
Sbjct: 2251 EKLGLAIKESDA---MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2307
Query: 659 VIESTEAI--EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT---- 712
VIE + + + ++ L E K+ + E + NE +EKLQ+++ ++ + +
Sbjct: 2308 VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2367
Query: 713 -------KISTQLDFASKRYEMLQDNVEGYRREITS----LHERNQKLTATTQKQEQIIN 761
+ QLD L+ VE E+T L E N K+ TQ+ +
Sbjct: 2368 SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE----LF 2423
Query: 762 TMTQDLRGANEKLAVAE----VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT 817
++ ++ + ++ E V ++L K+K L EV L+ E L Q +
Sbjct: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL---EVVLT---EDALKSLENQTYFKS 2477
Query: 818 NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
+ +G + ET Q L S + + E++ K++++ EQ T L ++++ +
Sbjct: 2478 FEENGKGSIINLETRLLQ-LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536
Query: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
+ ++ + L ++ A +E A Q + Q S +RT
Sbjct: 2537 KIVEEKVAAAL-VSQIQLEAVQEYAKFCQ-----DNQTISSEPERTN------------- 2577
Query: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
+ L Q E ++L + T + + ++ V + SL EK+ E KN+ + K+
Sbjct: 2578 IQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2635
Query: 998 AEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA 1057
E Q KL+E ++KQ ++ KR Q + LK T + + A
Sbjct: 2636 LELQ-----KLLEGNEKKQREKEKKRSP-----QDVEVLKTTTELFHSNEESGFFNELEA 2685
Query: 1058 LSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETT 1117
L E A + E A +A+ K + EL++ ++ +LQ ++ VR HL E
Sbjct: 2686 LRAESVATK--AELASYKEKAE-KLQEELLVKETNMTSLQ------KDLSQVRDHLAEAK 2736
Query: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE-KQNRLLHDQIE---KLSDKVVAS 1173
+K +LE + E +E SK C E L K ++ + Q + K+S
Sbjct: 2737 EKLS--ILEKEDETEVQE-------SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTP 2787
Query: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF---------EVAQVESLRY 1224
+ ++L E S+E I +F + +++ E +++ E+L+
Sbjct: 2788 QILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKR 2847
Query: 1225 RQ--RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKK----------------- 1265
V+LL+ E L+ + R K + +A + +
Sbjct: 2848 EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYL 2907
Query: 1266 TETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE---LDILPLQEANAELSEKSGMLQ 1322
T + + + E + + ++++ +R + + +L L E+ E + Q
Sbjct: 2908 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2967
Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
+ LEE + + +S KD T+ +L E EV+ + R + +
Sbjct: 2968 VSEPWLEE-----RKAYINTISSLKDLITK--MQLQREAEVYDSSQSHESFSDWRGELLL 3020
Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKET-----IQKDLDAKIIDIQEKVKTITQVKKI 1437
A L L+ + + +L + T +++ + + ++ Q ++ + + +
Sbjct: 3021 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR- 3079
Query: 1438 GRRYKTQYEELKAQQD-KVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ 1496
R ++ + L AQ + + + + + Q + +Q+ + + + + + S++ +
Sbjct: 3080 -RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR 3138
Query: 1497 VENLQKTLSEKETEARNLQEQTVQLQ--------------SELSRLRQDLQDRTTQEEQL 1542
LQ+ LS ++ L+ + Q + EL R +++D+T + L
Sbjct: 3139 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198
Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL-------KQRNGALDQQKDEL 1595
+ +++K+R+ A + + A L +++ +E E+L KQRN L+ ++
Sbjct: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258
Query: 1596 DVRITALKSQYEGRISRLERELREHQERHLE 1626
+ + + E + + +L E Q R+LE
Sbjct: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLE 3289
Score = 143 bits (361), Expect = 2e-33
Identities = 315/1691 (18%), Positives = 680/1691 (40%), Gaps = 231/1691 (13%)
Query: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
E TE + + N LE + +S++ L+ EK K+E + Q E+E +S Q++L
Sbjct: 1300 EETEFLSIHSQMTN-LEDIDVNHKSKLSSLQDL-EKTKLEEQVQ--ELESLISSLQQQL- 1354
Query: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
ET Q+ E+ L +L+A++E + D + +S RT K+++
Sbjct: 1355 KETE--QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDG 1412
Query: 130 TNE-----RLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLE 184
T E + +E + K+ E+L+E K + + + Q +++S K
Sbjct: 1413 TIEFSGEFGVKEETNIVKLLEKQYQEQLEEE-VAKVIVSMSIAFAQQTELSRISGGKENT 1471
Query: 185 QEKELLHS---QNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMN 241
+ H+ Q E+K D++ + E +++K KEE L +++
Sbjct: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQI----GFQTFETVDVKF-----KEEFKPLSKELG 1522
Query: 242 G------LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295
L S+ H +D + + E + S ++ F + H ++S A+
Sbjct: 1523 EHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDEISVSSMDASRQ 1579
Query: 296 SEAKSNELTRAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELE 354
+L +EL + +E +A + + Q H+ ++E+ ++ E ++ E+I RL ++L
Sbjct: 1580 LMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLA 1638
Query: 355 NANDLLS---ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
+ + + ++R+ +L E E A + T+ N E Q ++
Sbjct: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEE 1697
Query: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLS---VKLEQAMKE---- 464
+ + K +++ +++ E IL +R ++A + + VK A++E
Sbjct: 1698 QTFKEKELDRKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 465 -IQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSS 523
+ + + + K+ +S++ R ++ + RV + G+ + R++
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811
Query: 524 ADISSSSEVISQHLVSY---------RNIEELQQQNQRLLVALRELGETREREEQETTSS 574
+ ++ +SQ LV N E + + RL A+ +L E + +
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 575 KITELQLKLESALTELEQLR--KSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
K+T+ +L ES + E K ++ + + R R+ + LS+ GV
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGY 1927
Query: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKA----- 687
D+ +L + T + + S E +A +Q+QE E ++K
Sbjct: 1928 ADEKTLFERQIQEKTD-IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAE 1986
Query: 688 ----------ENEKIQNEQLE---------------------KLQEQVT----------- 705
E EK+ E+LE ++EQV+
Sbjct: 1987 AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046
Query: 706 ---DLRSQNTKISTQLD----FASKRYEMLQDNVEGYRREITSLHE------RNQKLTA- 751
DLR QN + QL+ F ++ + + +++EI L + R Q ++
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106
Query: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
T++ EQ+ N + + +E L E ++++ E ++ E R+ + ++LL E R
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRK 2166
Query: 812 Q-NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
+ + + ++E + R +I LE ++ +++LEN+ E+ L L+
Sbjct: 2167 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE 2226
Query: 871 VQLLDTK---RQLDTETNLHLNTKELLKNAQKE---IATLKQH---------LSNMEVQV 915
+Q ++ ++L+ E L + E L A KE ++T QH + EV++
Sbjct: 2227 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2286
Query: 916 ASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE----QYQAMVTS 971
Q +++ K Q K D+ V + + E + DL+ +++ S+ E + +
Sbjct: 2287 -DQLNEQVTKLQQQLKITTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343
Query: 972 LEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQ 1031
L E + K +Q + + + +E L+ +L V EK L+ A E M
Sbjct: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403
Query: 1032 QLSELKKTLSSVQNEVQE--ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLH 1089
+ LK+T + QE +L+R ++ Q + +A++ +K + EL +
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP---ENSVNVAIDHLSKDKPELEVV 2460
Query: 1090 AADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRC 1149
+ +AL++ + Q + S ++ + + E++LL+ +++ ++ E+++C +
Sbjct: 2461 LTE-DALKSLENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQI 2514
Query: 1150 EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEI 1209
+D+++Q + + ++K + V+E V L + E + E +F + + I
Sbjct: 2515 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-----VQEYAKFCQDNQTI 2569
Query: 1210 AET--RFEVAQVESLRYRQ----------RVELLERELQELQDSLNAEREKVQVTAKTMA 1257
+ R + + LR + R+ LE ++ E+ SL E+E+V++ K +
Sbjct: 2570 SSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2629
Query: 1258 QHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEK 1317
+ E KK + ++E N+ + EKE
Sbjct: 2630 EKE---KKLLELQKLLEGNEKKQREKE--------------------------------- 2653
Query: 1318 SGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGR 1377
KK +DV+ K + S ++ E L +E + E+ +
Sbjct: 2654 -------KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2706
Query: 1378 LKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKI 1437
L+ E+ ++T+ Q + +++ L + + + ++K+ + ++ + ++ K+
Sbjct: 2707 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKL 2766
Query: 1438 GRRYKTQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLE-- 1494
+ +Q + LK + Q S +E+ E ++Q K + ++
Sbjct: 2767 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2826
Query: 1495 --SQVENLQ-KTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
+++ +++ + +SE ET R L+ E L+ +Q ++E ++ +
Sbjct: 2827 HAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDA 2886
Query: 1552 KTRKAIVAAKS 1562
+ I ++ S
Sbjct: 2887 YQTREICSSDS 2897
Score = 138 bits (347), Expect = 7e-32
Identities = 318/1616 (19%), Positives = 661/1616 (40%), Gaps = 211/1616 (13%)
Query: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
V +++L+ L + KLE+ + + +S I L+ + ++ + E + ++KRL E
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
V + S+ + + + K + D I +F KEE K
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433
Query: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
+ E+L +E+ + + + E + G + QA +V +E+ E
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491
Query: 188 ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
+L Q T+ ++K K +E L +E G E+ KE + L
Sbjct: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531
Query: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
S+ H +D + + E+ S ++ F + H ++S A+ +L
Sbjct: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588
Query: 305 RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361
+EL + +E +A + + Q H+ ++E+ ++ E ++ E+I RL ++L + + +
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647
Query: 362 -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
++R+ +L E E A + T+ N E Q ++ + + K ++
Sbjct: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706
Query: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472
+ +++ E IL +R ++A + + VK A++E + + + +
Sbjct: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 473 DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
K+ +S++ R ++ + RV + G+ + R++ + ++
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
Query: 533 ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
+SQ LV N E + + RL A+ +L E + +K+T+ +L
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
Query: 584 ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
ES E + K ++ + + R R+ + LS+ GV D+ +L
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936
Query: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEK--------------- 686
+ T + + S E +A +Q+QE E ++K
Sbjct: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
Query: 687 AENEKIQNEQLE----------KLQEQV-------------------------TDLRSQN 711
E EK+ E+LE LQ+QV DLR QN
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055
Query: 712 TKISTQLD----FASKRYEMLQDNVEGYRREITSLHE------RNQKLTA-TTQKQEQII 760
+ QL+ F ++ + + +++EI L + R Q ++ T++ EQ+
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLA 2115
Query: 761 NTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ-NLLLTNL 819
N + + +E L E ++++ E ++ E R+ + ++LL E R +
Sbjct: 2116 NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKP 2175
Query: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK-- 877
+ + ++E + R +I LE ++ +++LEN+ E+ L L++Q ++
Sbjct: 2176 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2235
Query: 878 -RQLDTETNLHLNTKELLKNAQKE---IATLKQH---------LSNMEVQVASQSSQRTG 924
++L+ E L + E L A KE ++T QH + EV++ Q +++
Sbjct: 2236 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI-DQLNEQVT 2294
Query: 925 KGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE----QYQAMVTSLEESLNKEK 980
K Q K D+ V + + E + DL+ +++ S+ E + + L E + K +
Sbjct: 2295 KLQQQLKITTDNKV--IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2352
Query: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Q + + + +E L+ +L V EK L+ A E M + LK+T
Sbjct: 2353 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2412
Query: 1041 SSVQNEVQE--ALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA 1098
+ QE +L+R ++ Q + +A++ +K + EL + + +AL++
Sbjct: 2413 FKMNQLTQELFSLKRERESVEKIQSIP---ENSVNVAIDHLSKDKPELEVVLTE-DALKS 2468
Query: 1099 AKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRL 1158
+ Q + S ++ + + E++LL+ +++ ++ E+++C + +D+++Q +
Sbjct: 2469 LENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQIKDMQEQGQF 2523
Query: 1159 LHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE--TRFEV 1216
+ ++K + V+E V L + E + E +F + + I+ R +
Sbjct: 2524 ETEMLQKKIVNLQKIVEEKVAAALVSQI-----QLEAVQEYAKFCQDNQTISSEPERTNI 2578
Query: 1217 AQVESLRYRQ----------RVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
+ LR + R+ LE ++ E+ SL E+E+V++ K + + E KK
Sbjct: 2579 QNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE---KKL 2635
Query: 1267 ETMNVVMETN--KMLREEKERLEQDLQQMQAKVRKL----------ELDILPLQEANAEL 1314
+ ++E N K +EK+R QD++ ++ EL+ L + +
Sbjct: 2636 LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKA 2695
Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARN-QHLVSQQKDPDTEEYRKL-LSEKEVHTKRIQQLT 1372
S +AEK E VK + Q +SQ +D E KL + EKE T+ +Q+
Sbjct: 2696 ELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE-VQESK 2754
Query: 1373 EE--IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII--DIQEKV 1428
+ L ++++S AS T+ I S ++ + IQ +L ++ ++ E +
Sbjct: 2755 KACMFEPLPIKLSKSIASQTDGTLKISS-SNQTPQILVKNAGIQINLQSECSSEEVTEII 2813
Query: 1429 KTITQ-VKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL 1483
T+ ++K+ + + +++++ ET +E +V+VQ ++E TL
Sbjct: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETL------KREHYVAVQLLKEECGTL 2863
Score = 136 bits (343), Expect = 2e-31
Identities = 370/1864 (19%), Positives = 738/1864 (39%), Gaps = 314/1864 (16%)
Query: 12 TELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNE 71
T+++ L V + S+++ G K VE + + + QE+L+ +
Sbjct: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD 1073
Query: 72 -----TRECQSLRL----ELEKLNNQLKALTEKNKELEIAQDR-----NIAIQSQFTRTK 117
T+E SLR E +KL +L L + +L + + ++ + + +
Sbjct: 1074 HLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
E +E EK + + L +EL + E+ + +K+ + + Q DE + + +
Sbjct: 1133 EYMENEKDKALCS---LKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIG 1189
Query: 178 YREKRLEQE-----KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN--LENKK 230
+K + +E + L + LK E+ A +E + + + L++ +
Sbjct: 1190 KLQKAVSEECSYFLQTLCSVLGEYYTPALKC---EVNAEDKENSGDYISENEDPELQDYR 1246
Query: 231 EEVSRLEEQMNGL--KTSNEH-----LQKHVEDLL------TKLKEAKEQQASMEEKF-- 275
EV +E M+ L K + E+ LQ + + KL+ +E E +F
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLS 1306
Query: 276 -HNEL--------NAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
H+++ N KLS+L + + +L V+EL L+ ++Q
Sbjct: 1307 IHSQMTNLEDIDVNHKSKLSSL-------QDLEKTKLEEQVQELESLI-------SSLQQ 1352
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENAND--LLSATKRKGAILSEEELAAMSPTAAA 384
L E EQ+ + +I L+K L+ ++ + + +++E + +
Sbjct: 1353 QLKETEQNYE-------AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSC 1405
Query: 385 VAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY 444
V K + ++ + + ET + KL K+ + L+E V +V I Q+ E
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETN----IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTEL 1461
Query: 445 ER--------AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDL 496
R A A + EQ +L +D +V + + K+L
Sbjct: 1462 SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 497 SQQIRVLLM------ELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN 550
+ + +L+ ++ E++ + EE+ S D + ++ Q + ++ +
Sbjct: 1522 GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKD---KTFIVRQSIHDEISVSSMDASR 1578
Query: 551 QRLL--VALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
Q +L L ++ + R+ QE + TEL + + Q+ + R+ Q QL + I
Sbjct: 1579 QLMLNEEQLEDMRQELVRQYQE--HQQATELLRQ-----AHMRQMERQREDQEQLQEEIK 1631
Query: 609 R------QRDMY--RILLSQTTGVAIPLHASSLDDVSLASTPK-----RPSTSQTVSTPA 655
R QR L+S+ V + +L +SLA K R S++QT +
Sbjct: 1632 RLNRQLAQRSSIDNENLVSERERVLLE-ELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690
Query: 656 PVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL-------- 707
+E E + K E E+ +K N L+ L E V
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 708 --------RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
RS ++ S L + S+ ++ V +T + + + +
Sbjct: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810
Query: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLS-EVRLSQQRESLLAEQRGQNLLLTN 818
+ +T++ +++L + + E E L L+ RL E LL + L +
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
Query: 819 LQTIQGILERSETETKQRLSSQIEKLE------HEISHLKKKLENEVEQRHTLTRNLDVQ 872
+ Q L R KQ + ++ E HE S +++L E+ + + +
Sbjct: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
Query: 873 LLDTKRQLDTETNLHLNTKELL---KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
+RQ+ +T++ ++ L N +E+ +Q + ++ Q + P
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 930 NKEDVDDLVSQLR-------QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
++ + + ++ Q E+ +DL++++K +VE+ + LE+ N E
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 983 TEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL------ 1036
+ + +E +L++ +F L+++ ++ E E+ Q + I+ +EQQL +
Sbjct: 2051 LRQQNQALEKQLEKMRKF---LDEQAIDREHERDVFQQE----IQKLEQQLKVVPRFQPI 2103
Query: 1037 ----KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ---NKYERELML- 1088
+ + + N ++E + S L +++Q +RD QE+ + + + + E+ L++
Sbjct: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163
Query: 1089 ---HAADVEA---------LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
H VEA LQA ++ + + +LEE ++ +L ++
Sbjct: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2223
Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
L+ + + R ++LE++N+L D +EKL L + S+ +Q+Q
Sbjct: 2224 QLEIQKKESTTRLQELEQENKLFKDDMEKLG--------------LAIKESDAMSTQDQH 2269
Query: 1197 LEILRF--IRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
+ +F I +EKE+ E+ Q+ ++V L+++L+ D+ E EK ++
Sbjct: 2270 VLFGKFAQIIQEKEV-----EIDQL-----NEQVTKLQQQLKITTDNKVIE-EKNELIRD 2318
Query: 1255 TMAQHEELMKKTETMNVVMETN-KMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAE 1313
Q E LM E + E + L E E+L+Q+L + +K ++ L E
Sbjct: 2319 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG---QKTSMNAHSLSEEADS 2375
Query: 1314 LSEKSGMLQAEKKLLEEDVK------------------RWKARNQHLVSQQKDPDTEEYR 1355
L + ++ AEK LE+ V+ + Q L S +++ ++ E
Sbjct: 2376 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2435
Query: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKE---------DLNKV 1406
+ + E V+ I L+++ L+ + NQ +S +E + +
Sbjct: 2436 QSIPENSVNV-AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2494
Query: 1407 RTEKETIQKDLD-----AKIIDIQEKVKTITQV--KKIGRRYKTQYEELKAQ-----QDK 1454
+ E KDL+ +I D+QE+ + T++ KKI K E++ A Q +
Sbjct: 2495 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2554
Query: 1455 VMETSAQSSGDHQ-----EQHVSVQEMQELKE----------TLNQAETKSKSLE----- 1494
++ A+ D+Q + ++Q + +L+E TL +E +S+ +E
Sbjct: 2555 AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2614
Query: 1495 ----SQVENLQKTLSEKETEARNLQE-----QTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
QVE +K + EKE + LQ+ + Q + E R QD++ T E
Sbjct: 2615 ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2674
Query: 1546 ----ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITA 1601
+ E R VA K A LA K++ K EEL + + +T+
Sbjct: 2675 EESGFFNELEALRAESVATK---AELASYKEKAEKLQEELLVK-----------ETNMTS 2720
Query: 1602 LKSQYEGRISRLERELREHQER--HLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
L+ +S++ L E +E+ LE+ DE +V E ++ + P + IA
Sbjct: 2721 LQKD----LSQVRDHLAEAKEKLSILEKEDE-----TEVQESKKACMFEPLPIKLSKSIA 2771
Query: 1660 STSD 1663
S +D
Sbjct: 2772 SQTD 2775
Score = 136 bits (342), Expect = 3e-31
Identities = 285/1390 (20%), Positives = 558/1390 (40%), Gaps = 279/1390 (20%)
Query: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
G + S HL+ +L K E +E +EE ++ +++A +
Sbjct: 149 GAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIIT 208
Query: 302 ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEKELEN--AND 358
+LT +++ + E ++ +++ L EQS K Q++ + L+ L + A D
Sbjct: 209 QLTANLQQARR------EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAAD 262
Query: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
LL A K IL+ ++ +E QD LL E + K+
Sbjct: 263 LLQA---KQQILTHQQ---------------------------QLEEQDHLL-EDYQKKK 291
Query: 419 IN-----KYLDEIVK--EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
+ +L E +K E+E + +EE + + + L+ K+ + K+ L++
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351
Query: 472 TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
A+K L+ Q+ +Q+I+ + +EL ++ SSE
Sbjct: 352 LTTADKLLGELQE-------QIVQKNQEIKNMKLELTNSKQKE------------RQSSE 392
Query: 532 VISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
I Q + + +EELQ++N + ++ + E+E Q EL + +++
Sbjct: 393 EIKQLMGT---VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMK 449
Query: 592 QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL--ASTPKRPSTSQ 649
Q RQH Q+ + R + L + + + L +V++ + + + SQ
Sbjct: 450 Q-ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Query: 650 TVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLR 708
+ +I +E K AL +QL+++ E + E+IQ + + + EQ + L
Sbjct: 509 KEKLKEELGLI-----LEEKCALQRQLEDLVEELSFSR---EQIQRAR-QTIAEQESKLN 559
Query: 709 SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
+ +ST VE + EI S E ++L + + ++ N +
Sbjct: 560 EAHKSLST---------------VEDLKAEIVSASESRKELEL--KHEAEVTNYKIKLEM 602
Query: 769 GANEKLAVAEVRAENLKKEKEMLKLS-----EVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
EK AV + AE+ + E E L+ E LS+ +E L E R + + L+
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR---INIEKLKDNL 659
Query: 824 GILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT 882
GI + + + Q +S +IE ++ E +L K +N++ + ++L L+++K +
Sbjct: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITK-QNQLILEISKLKDLQQSLVNSKSE--- 715
Query: 883 ETNLHLNTK----ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
E L +N E+L+ +KE TL+Q + ++++ Q KE +DL
Sbjct: 716 EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM--------KEKENDLQ 767
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-----KEKQVTEEVRKNIEVR 993
+ Q E + + LK+ KT ++ + + S EE L K K K IE+
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPV--SQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 994 LKESAEFQTQLEKKLMEVEKEK--------------QELQDD-------KRRAIESMEQQ 1032
++E+ + + Q + E+EK++ QELQ++ K +S +Q
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV-----EAQNKYERELM 1087
E K L ++ E+ LQR + + + D +++ +A E K ELM
Sbjct: 886 ELEYKSKLKALNEELH--LQRINPTTVKMKSSVFD-EDKTFVAETLEMGEVVEKDTTELM 942
Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
E L+ K + +++ L E ++ ++ + E + LK E +
Sbjct: 943 ------EKLEVTKREKLELSQRLSDLSEQLKQKHGEI----SFLNEEVKSLKQEKEQVSL 992
Query: 1148 RCEDLE---KQNRLLH-----DQIEKLSDKVVASVKEGVQGPL----------------- 1182
RC +LE NR + Q+ L D VV G +G +
Sbjct: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
Query: 1183 -----NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
N+++ EE K ++ IL+ L + +E + T+ E+ + ++ + +L+ E +
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSENDKLQKELNVLKSEQND 1108
Query: 1238 LQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKMLREEKERL----EQDLQQ 1292
L+ + A+R + + T + Q E M+ E +K L KE L E+ +++
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMEN--------EKDKALCSLKEELIFAQEEKIKE 1160
Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
+Q K+ +LEL + QE E ++ +K + E+ +
Sbjct: 1161 LQ-KIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF----------------- 1202
Query: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
+Q L +G + + + +N + E+ ++
Sbjct: 1203 ---------------LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDP 1240
Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
+D ++ D QE + T+ + +Y +L Q ++ + Q +
Sbjct: 1241 ELQDYRYEVQDFQENMHTLLN------KVTEEYNKLLVLQTRLSKIWGQQTDG------- 1287
Query: 1473 VQEMQELKETLNQAETKSKSLESQVENLQ--------KTLSEKETEARNLQEQTVQLQSE 1524
+++ +E L + ET+ S+ SQ+ NL+ K S ++ E L+EQ +L+S
Sbjct: 1288 -MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESL 1346
Query: 1525 LSRLRQDLQD 1534
+S L+Q L++
Sbjct: 1347 ISSLQQQLKE 1356
Score = 136 bits (342), Expect = 3e-31
Identities = 355/1705 (20%), Positives = 686/1705 (40%), Gaps = 346/1705 (20%)
Query: 7 QVLERTELNKLPKSVQNKLEKFLADQ-----------QSEIDGLKGRHE---KFKVESEQ 52
++++ + N+ + K+ KFL +Q Q EI L+ + + +F+ SE
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106
Query: 53 QYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE----------IA 102
Q E+E+ +H +E+ T +C L L E+L ++ E+ ++LE +
Sbjct: 2107 QTREVEQLANHLKEK----TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 103 QDRN----------IAIQSQFTRTKEELEAEKRDLIRTNERLSQ---ELEYLTEDVKRLN 149
+DR ++++ Q ++ ++ +++++ E+L Q ELE E+V++L+
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222
Query: 150 EKL----KESNTTKGELQ----LKLDELQASDVSVKYREK--------------RLEQEK 187
+L KES T EL+ L D+++ +++K + ++ QEK
Sbjct: 2223 MQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK 2282
Query: 188 EL----LHSQNTWLNTELKTKTDELLALGREKGNEIL------------ELKCNLENKKE 231
E+ L+ Q T L +LK TD + E+ NE++ + +C N++E
Sbjct: 2283 EVEIDQLNEQVTKLQQQLKITTDNKVI---EEKNELIRDLETQIECLMSDQECVKRNREE 2339
Query: 232 EVSRLEEQMN---------GLKTS-NEH-LQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
E+ +L E + G KTS N H L + + L +L ++ ++E++
Sbjct: 2340 EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2399
Query: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV---EQSKDQ 337
+ N+ K ++ K N+LT+ + L K +E+ E ++I ++ + V SKD+
Sbjct: 2400 EMTFMKNVLK----ETNFKMNQLTQELFSL-KRERESVEKIQSIPENSVNVAIDHLSKDK 2454
Query: 338 MEKEMLEKIGRLEKELENANDLLSATKR-KGAILS-EEELAAMSPTAAAVAKIVKPGMKL 395
E E++ L K LEN S + KG+I++ E L + T +A ++L
Sbjct: 2455 PELEVVLTEDAL-KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSA------KDLEL 2507
Query: 396 TELYNAYVETQDQ--LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEY-ERAQKAVA 452
T+ Y + Q+Q E L+ K +N L +IV+E A A + + Q E E A+
Sbjct: 2508 TQCYKQIKDMQEQGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQD 2565
Query: 453 SLSVKLEQAMKEIQRLQE-DTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEAR 511
+ ++ E IQ L + D+ S L +E QV ++ + + ++E A
Sbjct: 2566 NQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE 2625
Query: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
N + +++++ Q L+ ++ +++ +R + L T E
Sbjct: 2626 KNVLEKEKKLLEL----------QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2675
Query: 572 TSSKITELQ-LKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL--LSQTTGVAIPL 628
S EL+ L+ ES T+ E + + + +V++ +M + LSQ
Sbjct: 2676 ESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL--- 2732
Query: 629 HASSLDDVSLAS----TPKRPSTSQTVSTPAPVPVIES----TEAIEAKAALKQLQEIFE 680
A + + +S+ T + S + P P+ + +S T+ ++ Q +I
Sbjct: 2733 -AEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL- 2790
Query: 681 NYKKEKAENEKIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI 739
+N IQ N Q E E+VT++ SQ T E ++ E + EI
Sbjct: 2791 ------VKNAGIQINLQSECSSEEVTEIISQFT-------------EKIEKMQELHAAEI 2831
Query: 740 TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799
+ R+ T T +++ + + ++ G + A ++ K+ + +L+
Sbjct: 2832 LDMESRHISETETLKREHYVAVQLLKEECGTLK----AVIQCLRSKEGSSIPELAHSDAY 2887
Query: 800 QQRESLLAEQR---GQNLLLTNLQ----------------------TIQGILERSETETK 834
Q RE ++ GQ + LT+ Q I+G+L E
Sbjct: 2888 QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGM 2947
Query: 835 QRLS-SQIEKLEHEISHLKKKLENEVEQRHTLTRNLD-VQLLDTKRQLDTETNLHLNTKE 892
Q LS ++ + E +++ E +E+R + ++ L TK QL E ++ +++
Sbjct: 2948 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQS 3007
Query: 893 -------------------------LLKNAQKEIATLKQH-----LSNMEVQVASQSSQR 922
LL + E+ L L+ +E ++ Q +
Sbjct: 3008 HESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEY 3067
Query: 923 TGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS-----------NVEQYQAMV-- 969
+ K D L+S+++ Q+N K LK N++Q Q+ +
Sbjct: 3068 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLE 3127
Query: 970 ------------TSLEESLNKEKQVTEEVRKNI-------EVRLKESAEFQTQLEKKLME 1010
T L+E L+ EK V E++ + E LK + +LE +E
Sbjct: 3128 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE 3187
Query: 1011 VEKEKQELQDDKRRAIESMEQQL-SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQ 1069
V+ DK + + L SE KK+ E+Q AL++ L ++ ++
Sbjct: 3188 VK--------DKTDEVHLLNDTLASEQKKS-----RELQWALEKEKAKLGRSEERDKEEL 3234
Query: 1070 EQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKA 1129
E K ++E+Q +R L L+ + Q E K+ S R + + + + LE +
Sbjct: 3235 EDLKFSLESQK--QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292
Query: 1130 SWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEE 1189
E E++ E+S + R R LH Q++ SD G L E
Sbjct: 3293 LLES-EKVRIREMSSTLDR-------ERELHAQLQS-SDGT---------GQSRPPLPSE 3334
Query: 1190 GKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKV 1249
++L+ ++++ E +R E+ +Y+ L LQ E+++
Sbjct: 3335 --------DLLKELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKDR- 3376
Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
QV KT+ +E TE + E L+ + E L++ L++ + +V KL+L+ LQ
Sbjct: 3377 QVHRKTLQTEQE--ANTEGQKKMHE----LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430
Query: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
M + +K+ LE + KR R L +P T + V ++I+
Sbjct: 3431 I---------MQEFQKQELEREEKRESRR--ILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3479
Query: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL----------DA 1419
T+E A++ N T + ++ +++ L V ++ + + + D
Sbjct: 3480 GETKESN--YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDE 3537
Query: 1420 KIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQEL 1479
I +QE + I Q ++L QQ + + S+ +++ EL
Sbjct: 3538 DFIWVQENIDEII----------LQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3587
Query: 1480 KETLNQAETKSKSLESQVENLQKTL 1504
++Q + L + V L++ +
Sbjct: 3588 TGHISQLTEEKNDLRNMVMKLEEQI 3612
Score = 135 bits (340), Expect = 5e-31
Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)
Query: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800
R ++ EQ L +LA + E L +E E ++++ ++ Q
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194
Query: 801 QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
+ E+ + ++ G LT NLQ Q E+ ET + L+ Q +KL+ + L+ E
Sbjct: 195 EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
Query: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
H+ T LL K+Q+ T LL++ QK+ +S ++ ++
Sbjct: 252 RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308
Query: 919 SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970
++ K + SNKE+ +++L +++ + E++ +LK++L T+ + + Q +
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368
Query: 971 ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009
L S KE+Q +EE++ + ++ R + ++F+T + +++
Sbjct: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428
Query: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
++E+ + EL + + I M+Q+L +++++ + + E++ AL+ S NE Q
Sbjct: 429 KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
Query: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
+ + I ++ N + +L E L E+ + + L E +
Sbjct: 489 KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176
Q+ + + E+E L +E K + EDL+ + + ++L K A V E
Sbjct: 543 QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222
++ N L +SQE LE LR E+E++ E R + +++ +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273
Y+Q+++ L+ E+ + +++ E++ ++++ Q + K+E M + +
Sbjct: 662 HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721
Query: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322
E + +EEKE+ LEQ++Q++Q K LE + LQE A+L ++ +L+
Sbjct: 722 NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
EKK LE+ +K VSQ++ + K S+ V K I+ L EE LK
Sbjct: 782 DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833
Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Q IQ L E++ K R +K+ + ++QE+ + +VK K
Sbjct: 834 ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
Query: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
+ E +LKA +++ + + V ++ + ETL E K +
Sbjct: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
Query: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
E L+ T EK +L EQ Q E+S L ++++ ++EQ+ + E E
Sbjct: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998
Query: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
I+ ++ ++ Q++ LD +T EG +S++
Sbjct: 999 --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039
Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664
+ E + +E + + + +Q Q+ L P+ + + P
Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Score = 77.8 bits (190), Expect = 1e-13
Identities = 221/1156 (19%), Positives = 459/1156 (39%), Gaps = 180/1156 (15%)
Query: 44 EKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKN---KELE 100
EK +E E++ E++K L ++++ + ++ +E+ K +L E++ ELE
Sbjct: 2625 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELE 2684
Query: 101 IAQDRNIAIQSQFTRTKEELEAEKRDLI--RTN-----ERLSQELEYLTEDVKRLNEKLK 153
+ ++A +++ KE+ E + +L+ TN + LSQ ++L E ++L+ K
Sbjct: 2685 ALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK 2744
Query: 154 ESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
E T E+Q S + + ++ K + + L +T ++L +
Sbjct: 2745 EDET----------EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV--K 2792
Query: 214 EKGNEI-LELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME 272
G +I L+ +C+ E E +S+ E++ ++ + H ++L + + + S
Sbjct: 2793 NAGIQINLQSECSSEEVTEIISQFTEKIEKMQ------ELHAAEIL----DMESRHISET 2842
Query: 273 EKFHNELNAHIKLSNLYKSAADDSEA-----KSNELTRAVEELHKLLKEAGEANKAI--- 324
E E H L K +A +S E + E H + E +
Sbjct: 2843 ETLKRE---HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGS 2899
Query: 325 ---QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND--------LLSATKRKGA-ILSE 372
Q L Q D + GR E E E+A D LL A +G +LS
Sbjct: 2900 DWGQGIYLTHSQGFD------IASEGRGE-ESESATDSFPKKIKGLLRAVHNEGMQVLSL 2952
Query: 373 EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL--LLEKLENKRINKYLDEIVKEV 430
E ++ ++ +P + E AY+ T L L+ K++ +R
Sbjct: 2953 TESPYSDGEDHSIQQVSEPWL---EERKAYINTISSLKDLITKMQLQR------------ 2997
Query: 431 EAKAPILKRQREEYE--RAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRR 488
EA+ + E + R + +A V LE+ + + + +V +
Sbjct: 2998 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLE 3057
Query: 489 MEIQVKDLSQQIRVLLME-------LEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
IQ + + Q + ++ L E + H + + SE SQ L+ Y
Sbjct: 3058 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEY- 3116
Query: 542 NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE---QLRKSRQ 598
NI++ Q Q + V L + + +++ +S K+ +LK E A T+LE L+ +
Sbjct: 3117 NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK 3176
Query: 599 HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVP 658
H +L + +R+ + T D+V L
Sbjct: 3177 HLKEL--------EAFRLEVKDKT-----------DEVHL-------------------- 3197
Query: 659 VIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
+ T A E K + ++LQ E K + +E+ E+LE L+ + + +N +++ L
Sbjct: 3198 -LNDTLASEQKKS-RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLL 3255
Query: 719 DFASKRYEMLQDNVEG----YRREITSLHERNQKLTATTQKQEQIINTMTQDL---RGAN 771
+ + Q +E Y +++ RN +L + ++ I M+ L R +
Sbjct: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315
Query: 772 EKLAVAEVRAENLK--KEKEMLKLSEVRLSQQRESLLAE--QRGQNLLLTNLQTIQGI-- 825
+L ++ ++ +++LK + +L +++ S + E + L +LQT Q +
Sbjct: 3316 AQLQSSDGTGQSRPPLPSEDLLKELQKQL-EEKHSRIVELLNETEKYKLDSLQTRQQMEK 3374
Query: 826 ---LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQ------LLDT 876
+ R +T+Q +++ +K HE+ + L+ ++E++ LD++ ++
Sbjct: 3375 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3434
Query: 877 KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
++ + E ++ +L E T V Q + G+ + SN + +
Sbjct: 3435 FQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIE 3492
Query: 937 LVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE---VRKNIEVR 993
+ ++ ++++L+ S + Q + E L E E+ V++NI+
Sbjct: 3493 MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETADDEDFIWVQENID-- 3547
Query: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
E QL+ KL + E+ L E+ L + + + +E
Sbjct: 3548 -----EIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDL 3601
Query: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL 1113
+ + E+Q R Q A ++ R + A++EA+ A++++V + L
Sbjct: 3602 RNMVMKLEEQIRWYRQTGA-----GRDNSSRFSLNGGANIEAIIASEKEVWNREKLT--L 3654
Query: 1114 EETTQKAESQLLECKA 1129
+++ ++AE+++ + KA
Sbjct: 3655 QKSLKRAEAEVYKLKA 3670
Score = 57.0 bits (136), Expect = 2e-07
Identities = 121/629 (19%), Positives = 248/629 (39%), Gaps = 74/629 (11%)
Query: 11 RTELNKLPKS----VQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
RTEL L + + N LE+ + +Q E +K + EI+ +
Sbjct: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSEIQALHAQMNG 3095
Query: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRD 126
R + RE +S + E L ++ + E+++ +++ + T +E+L +EK
Sbjct: 3096 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMV 3152
Query: 127 LIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQE 186
+ L+Q L +K ++ LKE + E++ K DE
Sbjct: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE------------------ 3194
Query: 187 KELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTS 246
+H N L +E K + AL +EK +L + E KEE+ L+ + K
Sbjct: 3195 ---VHLLNDTLASEQKKSRELQWALEKEKA----KLGRSEERDKEELEDLKFSLESQKQR 3247
Query: 247 NEHLQKHVEDLLTKLKEAKE----QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE 302
N L +E L E+++ Q+ + + E +++L L +S S+
Sbjct: 3248 NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSST 3307
Query: 303 LTRAVEELHKLLKEA---GEANKAI--QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN 357
L R ELH L+ + G++ + +D L E+++ ++ ++E + EK ++
Sbjct: 3308 LDRE-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3366
Query: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
++ + + K+ + K+ +L E + Q+ LE +
Sbjct: 3367 QTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ 3426
Query: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA-SLSVKLEQAMKEIQRLQEDTDKAN 476
R+ + E K+ + + +R Y+ + SL+ + Q+++ +T ++N
Sbjct: 3427 RLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESN 3486
Query: 477 KQSSVLERD------NRRMEI---QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADIS 527
+ ++E + N +E+ +++ ++ +++VL + E DE+
Sbjct: 3487 -YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDED------- 3538
Query: 528 SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESAL 587
+ NI+E+ Q Q+L + GE T+ +TE L+ + L
Sbjct: 3539 --------FIWVQENIDEIILQLQKL---TGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3587
Query: 588 T-ELEQLRKSRQHQMQLVDSIVRQRDMYR 615
T + QL + + +V + Q YR
Sbjct: 3588 TGHISQLTEEKNDLRNMVMKLEEQIRWYR 3616
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 182 bits (462), Expect = 3e-45
Identities = 381/1857 (20%), Positives = 779/1857 (41%), Gaps = 315/1857 (16%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61
LQ+ ++ E+ + K V+N ++ + ++++ I+ L + EK +E + + +K L
Sbjct: 301 LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
Query: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIA--------- 108
QE++V + +E ++++LEL + + +E+ K+L E Q RN
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
Query: 109 --IQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
++ + R E+L AE K++LIR + ++Q E T + L+
Sbjct: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477
Query: 155 -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
SN T E Q+KL + +++++K ++ ++EK L EL +E AL R
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528
Query: 214 EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273
+ + + EL + E + + EQ + L +++ L VEDL ++ A E + +E
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587
Query: 274 KFHNEL-NAHIKLSNLYK--SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326
K E+ N IKL L K +A D A+S E L E +K +D
Sbjct: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386
H + +E+ KD + ++I L+ E+ + + K + + +S
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700
Query: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446
KL +L + V ++ + + ++E+ KE+E IL+++ +E
Sbjct: 701 -------KLKDLQQSLVNSKSE---------EMTLQINELQKEIE----ILRQEEKEKGT 740
Query: 447 AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499
++ V L +K LE+ MKE + LQE + ++S+L+ + + +E +K +SQ+
Sbjct: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800
Query: 500 IRVLLMELEEARGNHVIRDEEVS-----SADISSSSEVISQHLVSYRNI----------- 543
R++ ++ +++ + ++E+ + D+ +++ + RN
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 544 -EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
+ELQ++ LL +L +++ ++E E S KL+ AL E L++ ++
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKS--------KLK-ALNEELHLQRINPTTVK 911
Query: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
+ S+ + D + + G + + L + + ++ SQ +S +
Sbjct: 912 MKSSVFDE-DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962
Query: 663 TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719
+E ++ K + L E ++ K+EK E ++ +LE + + +++S +T++S+ LD
Sbjct: 963 SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 720 FASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ------------KQEQIINTMTQDL 767
M EG ++ K+ + KQEQ+I +
Sbjct: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
Query: 768 RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825
+ A + L+KE +LK + L Q E+ Q + L+ + + + +
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-------QRICLSLVYSTHVDQV 1131
Query: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
E E E + L S L+ E+ +++ E+++ H L++Q + T+ D
Sbjct: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183
Query: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
LHL +L K +E + Q L ++ + + + + + +KE+ D +S+ E
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE--DKENSGDYISENEDPE 1241
Query: 946 EQ-----VNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESLNKEK 980
Q V D +E + T + V E+Y ++ T L EE+L KE+
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Query: 981 --------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIESM 1029
Q+T E++ N + +L + + T+LE+++ E+E LQ + ++
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC--------------------- 1068
E ++ L+K L +V + + E A+R
Sbjct: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421
Query: 1069 -QEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEETTQKAESQLL- 1125
+E+ I + +Y+ +L A V ++ A Q ++++ + E T ++ +
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481
Query: 1126 ECKASWEERERMLKDEVSKCVCRCEDLE--KQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
+ + + ++ +D++ D++ ++ + L ++ + +++ S + P +
Sbjct: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541
Query: 1184 ----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR---------Y 1224
+++SEE S+++ + + I E ++ + Q+E +R +
Sbjct: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601
Query: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
+Q ELL + + ++E++Q K + + + N+V E ++L EE E
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661
Query: 1285 RLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKARNQH 1341
L+Q L + +L Q N E EK+L EDV N+
Sbjct: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
Query: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTNNQNL 1395
Q+ + K+L E T ++ E IGR ++ ++S+ASL
Sbjct: 1722 YALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIWRSEA 1775
Query: 1396 IQSLKEDLNK--VRTEKETIQK----DLDAKIIDIQEKV--------KTITQVKKIGRRY 1441
S+K +++ R E+I D+ I++ KV + + + G
Sbjct: 1776 EASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI 1835
Query: 1442 KTQYEEL--------KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493
+ EEL +A +K++E +++S Q +H V + + ++E+ Q + ++SL
Sbjct: 1836 DPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATESL 1893
Query: 1494 ESQVENLQKTLSEKE--------------------TEARNLQEQTVQLQSEL-SRLRQDL 1532
+ Q E L++ L E+ + + L E+ +Q ++++ RL Q+L
Sbjct: 1894 KCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
Query: 1533 ---QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
+R + E +QQI E+ E + A K A V+ QL +E E+L + +
Sbjct: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEAGPVEQQLLQETEKLMKEKLEVQ 2009
Query: 1590 QQ----KDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642
Q +D+L ++ AL+ E ++SR + QE++ E D Q+ N+ E+Q
Sbjct: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDLRQQ--NQALEKQ 2061
Score = 177 bits (450), Expect = 8e-44
Identities = 358/1779 (20%), Positives = 756/1779 (42%), Gaps = 272/1779 (15%)
Query: 6 QQVLERTEL-NKLPKSV---QNKLEKFLADQQS---EIDGLKGRHEKFKVESEQQYFEIE 58
+Q+ E+T++ ++L + + N+L++ A+QQ E + L + E K E+ +E
Sbjct: 1936 RQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP----VE 1991
Query: 59 KRLSHSQERLVNETRE--CQSLRLELEKLNNQLKALT---------------EKNKELEI 101
++L E+L+ E E CQ+ ++ + L Q+KAL EKN EL
Sbjct: 1992 QQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 102 AQDRNIAIQSQFTRTKEELEAE------KRDLIRTN-ERLSQEL----------EYLTED 144
+ +N A++ Q + ++ L+ + +RD+ + ++L Q+L E+ T +
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 145 VKRLNEKLKESNTTKGELQLKLDELQASDVS--------VKYREKRLEQEKELLHSQNTW 196
V++L LKE EL L ++LQ D+ +++R + LEQ LL S +T+
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQR-DIQERNEEIEKLEFRVRELEQ--ALLVSADTF 2167
Query: 197 LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVED 256
K ++ G + L L+ L+ +++ + R E+++ L+ E L++ E+
Sbjct: 2168 ------QKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE---EQLEQFREE 2218
Query: 257 LLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----AKSNELTRAVEELHK 312
L K +E ++ +E + +L K DD E A + ++ H
Sbjct: 2219 LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
Query: 313 LLKEAGEANKAIQDHLLEVEQSKDQMEK-EMLEKIGRLEKELENANDLLSATKRKGAILS 371
L G+ + IQ+ +E++Q +Q+ K + KI K +E N+L+ + + L
Sbjct: 2279 LF---GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2335
Query: 372 EEELAAMSPTAAAVAKIVKPGMKL-TELYNAYVETQDQLLLEKLENKRINKYLDEIVKEV 430
++ + ++ + KL EL N +T E + LD ++ E
Sbjct: 2336 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2395
Query: 431 EAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSV--------- 481
A ++ EE + + + K+ Q +E+ L+ + + K S+
Sbjct: 2396 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2455
Query: 482 --LERDNRRMEI-----QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVIS 534
L +D +E+ +K L Q E E +G+ + + + + + S++ +
Sbjct: 2456 DHLSKDKPELEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDL- 2513
Query: 535 QHLVSYRNIEELQQQNQ-RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQL 593
+ Y+ I+++Q+Q Q + +++ ++ E++ ++ ++++QL+ + Q
Sbjct: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ- 2572
Query: 594 RKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVST 653
Q + S + ++ + + + + A +L L S TS +
Sbjct: 2573 ------DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTS-LILE 2625
Query: 654 PAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTK 713
V + E +E + L +LQ++ E +K++ E EK ++ Q ++ + T+L N +
Sbjct: 2626 KEQVEIAEK-NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
Query: 714 ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEK 773
+ + R E + + E+ S E+ +KL +E + ++ +DL +
Sbjct: 2685 SGFFNELEALRAESV-----ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH 2739
Query: 774 LAVAEVRAENLKKEKE----------MLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
LA A+ + L+KE E M + ++LS +S+ ++ G + ++ QT Q
Sbjct: 2740 LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS---KSIASQTDGTLKISSSNQTPQ 2796
Query: 824 GILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
+++ + + + E++ IS +K+E ++++ H ++ ++++ +TE
Sbjct: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHA----AEILDMESRHISETE 2851
Query: 884 T--NLHLNTKELLKNAQKEIATLKQHLSNMEVQ----------------VASQSSQRTGK 925
T H +LLK + + Q L + E +S S G+
Sbjct: 2852 TLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
Query: 926 GQPSNKEDVDDLVSQLR--QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKE---- 979
G D+ S+ R ++E + +++K V V SL ES +
Sbjct: 2912 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2971
Query: 980 --KQVTE---EVRK---NIEVRLKE-SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME 1030
+QV+E E RK N LK+ + Q Q E ++ + + + D + + +++
Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031
Query: 1031 QQ-LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA---KIAVEAQNKYEREL 1086
Q L E L++ + E+ + L N + R QEQ + A+E K +R
Sbjct: 3032 QVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR--IQEQGVEYQAAMECLQKADRRS 3089
Query: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
+L ++++AL A + + ++++ E+ ++K +LLE
Sbjct: 3090 LL--SEIQALHA--QMNGRKITLKR--EQESEKPSQELLEYNIQ---------------- 3127
Query: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206
+KQ+++L Q+E ++S+K+ L E+ S++ ++ L+
Sbjct: 3128 ------QKQSQMLEMQVE------LSSMKDRA-----TELQEQLSSEKMVVAELK----- 3165
Query: 1207 KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT 1266
E+A+T+ E+ +++ +EL+ + + + ++V + T+A + KK+
Sbjct: 3166 SELAQTKLELETTLKAQHKHL-----KELEAFRLEVKDKTDEVHLLNDTLASEQ---KKS 3217
Query: 1267 ETMNVVMETNK-MLREEKERLEQDLQQMQ-----AKVRKLELDILPLQEANAELSEKSGM 1320
+ +E K L +ER +++L+ ++ K R L+L++L L++ L+E
Sbjct: 3218 RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL-LEQQKQLLNESQQK 3276
Query: 1321 LQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKA 1380
+++++ L + + + RN E + LL ++V RI++++ + R +
Sbjct: 3277 IESQRMLYDAQLSEEQGRNL------------ELQVLLESEKV---RIREMSSTLDRERE 3321
Query: 1381 EIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRR 1440
A+ +S Q+ EDL K +QK L +EK I ++ +
Sbjct: 3322 LHAQLQSSDGTGQSRPPLPSEDLLK------ELQKQL-------EEKHSRIVELLNETEK 3368
Query: 1441 YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL 1500
YK + + Q +K ++ V + +Q +E + + K L+S+VE+L
Sbjct: 3369 YKLDSLQTRQQMEK-------------DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3415
Query: 1501 QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAA 1560
Q+ L EK + L + +LQ + ++ +R + E R E T ++ +
Sbjct: 3416 QRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3475
Query: 1561 KSKIAHLAGVKDQLTKENE--ELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELR 1618
+++ L + TKE+ +L + NG EL++ ++ + + S+L+ +
Sbjct: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----IRQKLQCVASKLQVLPQ 3531
Query: 1619 EHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
+ ER L+ E V E +I L+ +G++G
Sbjct: 3532 KASER-LQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3569
Score = 158 bits (400), Expect = 5e-38
Identities = 346/1824 (18%), Positives = 740/1824 (40%), Gaps = 286/1824 (15%)
Query: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN 70
+ +L L K L++ Q++E++ L+ Q F E+ LS +E L
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLR----------TQLLFSHEEELSKLKEDLEI 646
Query: 71 ETRECQSLRLELEKLNNQL------------KALTEKNKELEIAQDRNIAIQSQFTRTKE 118
E R + +EKL + L +++K + ++ +D I Q+Q
Sbjct: 647 EHR------INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
Query: 119 ELEAEKRDLIRT-NERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
+L+ ++ L+ + +E ++ ++ L ++++ L ++ KE T + E+Q + + + +K
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Query: 178 YREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
+E L+++ L ++N+ L E KT D L E L ++++K ++ S E
Sbjct: 761 EKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD-SVWE 819
Query: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF---HNELNAHIKLSNLYKSAAD 294
+++ L NE L++ L ++++ + + E+ F + EL K +
Sbjct: 820 KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE 879
Query: 295 DSEAKS-----NELTRAVEELH---------KLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
DS+ K ++L EELH K+ + +K LE+ + ++
Sbjct: 880 DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 341 EMLEKIGRLEKEL----ENANDLLSATKRKGAILS--EEELAAMSPTAAAVA------KI 388
E++EK+ ++E + +DL K+K +S EE+ ++ V+ +I
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999
Query: 389 VKPGMKLTELYNAYVETQDQLLLEKLEN----------KRINKYLDEIVK-EVEAKAPIL 437
+ + + + +TQ LL+ + ++NK E K VE K
Sbjct: 1000 IINHNRAENVQSC--DTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
Query: 438 KRQREEYERAQKAVASL--SVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKD 495
E + ++ + SV E +++ Q + DK K+ +VL+ + + +Q++
Sbjct: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQ--PSENDKLQKELNVLKSEQNDLRLQME- 1114
Query: 496 LSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI---SQHLVSYRNIEELQQQNQR 552
+Q+I + L+ + E A S E+I + + + I +L+ Q +
Sbjct: 1115 -AQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMK 1173
Query: 553 ------------LLVALRELGETRE-------------------------REEQETTSSK 575
LL+ + + E E++E +
Sbjct: 1174 TQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDY 1233
Query: 576 ITELQ-LKLESALTELEQLRKSRQHQMQLVDS-----IVRQRDMYRILLSQTTGVAIPLH 629
I+E + +L+ E++ +++ + V +V Q + +I QT G+ +
Sbjct: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG 1293
Query: 630 ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAEN 689
+L PK E TE + + + L++I N+K + +
Sbjct: 1294 EENL--------PK-----------------EETEFLSIHSQMTNLEDIDVNHKSKLSS- 1327
Query: 690 EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
+Q+ + KL+EQV +L S + + QL ++ + Y EI L +R Q +
Sbjct: 1328 --LQDLEKTKLEEQVQELESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAV 1375
Query: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL------------KKEKEMLKLSEVR 797
+ +T ++++ A + +N+ K+E ++KL E +
Sbjct: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435
Query: 798 LSQQRESLLAEQRGQNLLL----TNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
+Q E +A+ + T L I G + T + ++ + ++ +H + +K
Sbjct: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISG--GKENTASSKQAHAVCQQEQHYFNEMKL 1493
Query: 854 KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
+ Q +DV+ + + L E H L + +I K + +
Sbjct: 1494 SQDQIGFQTF---ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550
Query: 914 QVASQSSQRTGKGQPSNKEDVD--DLVSQLRQTEEQVNDLKERLKTSTSNVEQY-----Q 966
++ S+ + ++ V D QL EEQ+ D+++ L +Q Q
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610
Query: 967 AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK---QELQDDKR 1023
A + +E ++Q+ EE++ RL ++ ++ + + E+E+ +EL+ K+
Sbjct: 1611 AHMRQMERQREDQEQLQEEIK-----RLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 1024 RAIESMEQQLSELKKTLSSVQN------EVQEALQRASTALSNEQQARRDCQEQAKIAVE 1077
++ E+ EL+ + + QN EV+E + + + + A++
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQ 1725
Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSK-------MASVRQHLEETTQKAESQLLECKAS 1130
N +++L V+ A +E + + +S Q ++E++
Sbjct: 1726 KANNRLLKILLEV--VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCV 1783
Query: 1131 WEERERMLKDEV---SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ-GPLNVSL 1186
EE R+ + + S D+ +++ + E LS ++V S G + P N L
Sbjct: 1784 HEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEEL 1842
Query: 1187 SEEGKSQ-----EQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDS 1241
S+ E++LE + + E A+ ES R +Q + +EL++
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902
Query: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE---RLEQDLQQMQAKVR 1298
L+ E + A +++ E ++ + E + ++E+ + RLEQ+L +++
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTLFE--RQIQEKTDIIDRLEQELLCASNRLQ 1960
Query: 1299 KLELDILPLQEANAELSEKSGMLQAE-----KKLLEEDVKRWKARNQHLVSQQKDPDT-- 1351
+LE + +QE LS + ++AE ++LL+E K K + + +K D
Sbjct: 1961 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
++ + L + E R +L +E ++ + N +L + ++ +++ L++ ++E
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL---EKQLEKMRKFLDEQAIDRE 2077
Query: 1412 TIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEEL----KAQQDKVME---TSAQSSG 1464
+ +I +++++K + + + I + E+L K + DK E + Q
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137
Query: 1465 DHQEQHVSVQEMQELKETLNQA--------------------ETKSK-SLESQVENLQKT 1503
D QE++ +++++ L QA E K + SLE Q++ +
Sbjct: 2138 DIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDA 2197
Query: 1504 LSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAK 1561
+ KE E NL+EQ L + R++L+++ + +QL Q I +KE TR + +
Sbjct: 2198 IDRKEKEITNLEEQ-------LEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
Query: 1562 SKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQ 1621
+K+ KD + K +K+ + Q + L + + + E I +L ++ + Q
Sbjct: 2251 NKL-----FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305
Query: 1622 ERHLEQRDEPQEPSNKVPEQQRQI 1645
++ D NKV E++ ++
Sbjct: 2306 QQLKITTD------NKVIEEKNEL 2323
Score = 150 bits (379), Expect = 1e-35
Identities = 340/1665 (20%), Positives = 678/1665 (40%), Gaps = 213/1665 (12%)
Query: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
V +++L+ L + KLE+ + + +S I L+ + ++ + E + ++KRL E
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
V + S+ + + + K + D I +F KEE K
Sbjct: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433
Query: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187
+ E+L +E+ + + + E + G + QA +V +E+ E
Sbjct: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491
Query: 188 ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244
+L Q T+ ++K K +E L +E G E+ KE + L
Sbjct: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531
Query: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304
S+ H +D + + E+ S ++ F + H ++S A+ +L
Sbjct: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588
Query: 305 RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361
+EL + +E +A + + Q H+ ++E+ ++ E ++ E+I RL ++L + + +
Sbjct: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647
Query: 362 -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420
++R+ +L E E A + T+ N E Q ++ + + K ++
Sbjct: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706
Query: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472
+ +++ E IL +R ++A + + VK A++E + + + +
Sbjct: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 473 DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532
K+ +S++ R ++ + RV + G+ + R++ + ++
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820
Query: 533 ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583
+SQ LV N E + + RL A+ +L E + +K+T+ +L
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880
Query: 584 ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
ES E + K ++ + + R R+ + LS+ GV D+ +L
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936
Query: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE----KAENEKIQNEQL 697
+ T + + S E +A +Q+QE E ++ KAE ++ + L
Sbjct: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995
Query: 698 ---EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
EKL ++ +++ Q K+ L K E+ D E R I E+N +L Q
Sbjct: 1996 QETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI--DVEEQVSRFIELEQEKNTELMDLRQ 2053
Query: 755 KQEQIINTMTQDLRGANEKLAV-----AEVRAENLKKEKEMLKL---------SEVRLSQ 800
Q Q + + +R ++ A+ +V + ++K ++ LK+ + R +
Sbjct: 2054 -QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVE 2112
Query: 801 QRESLLAEQ--RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENE 858
Q + L E+ + LLL+ Q + I ER+E +IEKLE + L++ L
Sbjct: 2113 QLANHLKEKTDKCSELLLSKEQLQRDIQERNE---------EIEKLEFRVRELEQALLVS 2163
Query: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM--EVQVA 916
+ + ++ K +L E L ++ + +KEI L++ L E++
Sbjct: 2164 ADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-RDAIDRKEKEITNLEEQLEQFREELENK 2222
Query: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
++ Q+ K++ + +L Q + D E+L + +++ AM T + L
Sbjct: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA---IKESDAMSTQDQHVL 2279
Query: 977 -NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL-MEVEKEKQELQDDKRRAIESM----- 1029
K Q+ +E I+ ++ + Q QL+ +V +EK EL D IE +
Sbjct: 2280 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2339
Query: 1030 ------EQQLSELKKTLSSVQNEVQEALQRAST---ALSNEQQARR---DCQEQAKIAVE 1077
E+++ +L + + +Q E+ Q+ S +LS E + + D K+A+E
Sbjct: 2340 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2399
Query: 1078 AQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
Q + E M +V KE KM + Q L ++ ES + + ++ E +
Sbjct: 2400 QQVETANEEMTFMKNV-----LKETNFKMNQLTQELFSLKRERES-VEKIQSIPENSVNV 2453
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV-VASVKEGVQGP-LNVS---LSEEGKS 1192
D +SK + E + L D ++ L ++ S +E +G +N+ L E
Sbjct: 2454 AIDHLSK-----DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV 2508
Query: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL---NAEREKV 1249
+ LE+ + ++ K++ E Q E+ ++++ L++ ++E + + E V
Sbjct: 2509 SAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2564
Query: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI----- 1304
Q AK ++ + + E N+ + LRE++ L D+ + ++ +LE +
Sbjct: 2565 QEYAKFCQDNQTISSEPERTNI--QNLNQLREDE--LGSDISALTLRISELESQVVEMHT 2620
Query: 1305 -LPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
L L++ E++EK+ +L+ EKKLLE + + + Q +++ P E K +E
Sbjct: 2621 SLILEKEQVEIAEKN-VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL- 2678
Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
H+ E+ L+AE + A L + + + L+E+L T ++QKDL
Sbjct: 2679 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDL----- 2733
Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
+QV+ D + E + S +E VQE ++
Sbjct: 2734 ---------SQVR-----------------DHLAEAKEKLSILEKEDETEVQESKKACMF 2767
Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEE-- 1540
SKS+ SQ + K S QT Q+ + + ++ +LQ + EE
Sbjct: 2768 EPLPIKLSKSIASQTDGTLKISS---------SNQTPQILVKNAGIQINLQSECSSEEVT 2818
Query: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN 1585
++ Q TEK EK ++ A + ++ + E E LK+ +
Sbjct: 2819 EIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREH 2857
Score = 140 bits (353), Expect = 1e-32
Identities = 346/1772 (19%), Positives = 707/1772 (39%), Gaps = 295/1772 (16%)
Query: 45 KFKVESEQQYFEI-----EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99
KFK E + E+ E LS+S + E+++C L + E + + ++
Sbjct: 1509 KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSIHD 1567
Query: 100 EIAQDRNIAIQSQFTRTKEELEAEKRDLI------------------RTNERLSQELEYL 141
EI+ ++ Q +E+LE +++L+ R ER ++ E L
Sbjct: 1568 EISVS-SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626
Query: 142 TEDVKRLNEKLKESNTTKGE------LQLKLDELQA-SDVSVKYREKR-LEQEKELLHSQ 193
E++KRLN +L + ++ E ++ L+EL+A +S+ REK E +Q
Sbjct: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686
Query: 194 NTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSR--LEEQMNGLKTS---N 247
N N E++ +T + L R+ + E+ N ++ + L+ + +KT+
Sbjct: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746
Query: 248 EHLQKHVEDLLTKLKEAK---------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
E + +HV +L + +++ E +AS++ H E H ++++ + S+
Sbjct: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE---HTRVTDESIPSYSGSDM 1803
Query: 299 KSNEL------TRAVEELHKLLKEAGEANKAI----QDHLLEVEQSKDQMEKEMLEKIGR 348
N++ T EL + L +G A I ++ +L + +++LE I
Sbjct: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863
Query: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
+LE+A + R+ +E + +K +L E + ++Q
Sbjct: 1864 TSSQLEHAKVTQTELMRESFRQKQE-----------ATESLKCQEELRERLHEESRAREQ 1912
Query: 409 LLLE--KLENKRINKYLDE---IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMK 463
L +E K E I+ Y DE ++++ K I+ R +E A + L + +Q +
Sbjct: 1913 LAVELSKAEGV-IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 464 EIQRLQEDTDKANKQSSVLERD---------NRRMEIQVK------DLSQQIRVLLMELE 508
E + L + ++ +E+ ++E+Q + DL +Q++ L +++E
Sbjct: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031
Query: 509 EARGNHVIRDEEVSS--ADISSSSEVISQHLVSYRNI----------------EELQQQN 550
E + ++E ++ D+ ++ + + L R +E+Q+
Sbjct: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
Query: 551 QRLLVALR--ELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSI- 607
Q+L V R + E + R E E ++ + E K L EQL++ Q + + ++ +
Sbjct: 2092 QQLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE 2150
Query: 608 VRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIE 667
R R++ + LL V+ D + +P S V A I+ E
Sbjct: 2151 FRVRELEQALL-----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE--- 2202
Query: 668 AKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
+ L+E E + +E+ EN +NE++++L Q L Q + +T+L + ++
Sbjct: 2203 --KEITNLEEQLEQF-REELEN---KNEEVQQLHMQ---LEIQKKESTTRLQELEQENKL 2253
Query: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
+D++E I + +TQ Q + Q ++ EK + E + K
Sbjct: 2254 FKDDMEKLGLAI------KESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKL 2304
Query: 788 KEMLKL-SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEH 846
++ LK+ ++ ++ +++ L+ + Q + L + Q ++R+ E ++L+ IEKL+
Sbjct: 2305 QQQLKITTDNKVIEEKNELIRDLETQ---IECLMSDQECVKRNREEEIEQLNEVIEKLQQ 2361
Query: 847 EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQ 906
E++++ +K H+L+ D K QLD L ++ ++ A +E+ +K
Sbjct: 2362 ELANIGQKTSMNA---HSLSEEAD----SLKHQLDVVIAEKLALEQQVETANEEMTFMK- 2413
Query: 907 HLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQ 966
+ L++T ++N L + L + E +
Sbjct: 2414 --------------------------------NVLKETNFKMNQLTQELFSLKRERESVE 2441
Query: 967 AMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
+ + E S+N + + +EV L E A K +E + + +++ + +I
Sbjct: 2442 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDA-------LKSLENQTYFKSFEENGKGSI 2494
Query: 1027 ESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
++E +L +L+ T+S+ E+ + ++ ++Q + + + K V Q E ++
Sbjct: 2495 INLETRLLQLESTVSAKDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKV 2551
Query: 1087 MLHAADVEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKC 1145
AA V +Q A ++ +K Q + ++ Q L + RE L ++S
Sbjct: 2552 A--AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLN-----QLREDELGSDISAL 2604
Query: 1146 VCRCEDLEKQNRLLHDQIEKLSDKVVASVK---EGVQGPLNVSLSEEGKSQEQILEILRF 1202
R +LE Q +H + ++V + K E + L + EG ++Q + +
Sbjct: 2605 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664
Query: 1203 IRREKEIAETRFEVAQV-ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
++ E+ +T E+ E + +E L E + L + +EK + Q E
Sbjct: 2665 SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE-----KLQEEL 2719
Query: 1262 LMKKTETMNVVMETNKM---LREEKERL----EQDLQQMQAKVRKLELDILPLQEANAEL 1314
L+K+T ++ + +++ L E KE+L ++D ++Q + + LP++ + +
Sbjct: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIA 2779
Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE-------------- 1360
S+ G L+ + A Q ++ Q + +EE +++S+
Sbjct: 2780 SQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAA 2837
Query: 1361 ----------------KEVHTKRIQQLTEEIGRLKA--------------EIARSNASLT 1390
K H +Q L EE G LKA E+A S+A T
Sbjct: 2838 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2897
Query: 1391 NNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKA 1450
+ D + + D+ ++ + + T + KKI + + E
Sbjct: 2898 -REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE-GM 2955
Query: 1451 QQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETE 1510
Q + E+ DH Q VS ++E K +N SL+ + +Q + +
Sbjct: 2956 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI----SSLKDLITKMQLQREAEVYD 3011
Query: 1511 ARNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568
+ E + EL Q L++R+ R ++T ++ +
Sbjct: 3012 SSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3071
Query: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE------------ 1616
GV+ Q E + R L + I AL +Q GR L+RE
Sbjct: 3072 GVEYQAAMECLQKADRRSLLSE--------IQALHAQMNGRKITLKREQESEKPSQELLE 3123
Query: 1617 --LREHQERHLEQRDEPQEPSNKVPEQQRQIT 1646
+++ Q + LE + E ++ E Q Q++
Sbjct: 3124 YNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
Score = 136 bits (342), Expect = 3e-31
Identities = 285/1390 (20%), Positives = 558/1390 (40%), Gaps = 279/1390 (20%)
Query: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
G + S HL+ +L K E +E +EE ++ +++A +
Sbjct: 149 GAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIIT 208
Query: 302 ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQS-KDQMEKEMLEKIGRLEKELEN--AND 358
+LT +++ + E ++ +++ L EQS K Q++ + L+ L + A D
Sbjct: 209 QLTANLQQARR------EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAAD 262
Query: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
LL A K IL+ ++ +E QD LL E + K+
Sbjct: 263 LLQA---KQQILTHQQ---------------------------QLEEQDHLL-EDYQKKK 291
Query: 419 IN-----KYLDEIVK--EVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQED 471
+ +L E +K E+E + +EE + + + L+ K+ + K+ L++
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDK 351
Query: 472 TDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSE 531
A+K L+ Q+ +Q+I+ + +EL ++ SSE
Sbjct: 352 LTTADKLLGELQE-------QIVQKNQEIKNMKLELTNSKQKE------------RQSSE 392
Query: 532 VISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELE 591
I Q + + +EELQ++N + ++ + E+E Q EL + +++
Sbjct: 393 EIKQLMGT---VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMK 449
Query: 592 QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL--ASTPKRPSTSQ 649
Q RQH Q+ + R + L + + + L +V++ + + + SQ
Sbjct: 450 Q-ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQ 508
Query: 650 TVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLR 708
+ +I +E K AL +QL+++ E + E+IQ + + + EQ + L
Sbjct: 509 KEKLKEELGLI-----LEEKCALQRQLEDLVEELSFSR---EQIQRAR-QTIAEQESKLN 559
Query: 709 SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
+ +ST VE + EI S E ++L + + ++ N +
Sbjct: 560 EAHKSLST---------------VEDLKAEIVSASESRKELEL--KHEAEVTNYKIKLEM 602
Query: 769 GANEKLAVAEVRAENLKKEKEMLKLS-----EVRLSQQRESLLAEQRGQNLLLTNLQTIQ 823
EK AV + AE+ + E E L+ E LS+ +E L E R + + L+
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR---INIEKLKDNL 659
Query: 824 GILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT 882
GI + + + Q +S +IE ++ E +L K +N++ + ++L L+++K +
Sbjct: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITK-QNQLILEISKLKDLQQSLVNSKSE--- 715
Query: 883 ETNLHLNTK----ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLV 938
E L +N E+L+ +KE TL+Q + ++++ Q KE +DL
Sbjct: 716 EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM--------KEKENDLQ 767
Query: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-----KEKQVTEEVRKNIEVR 993
+ Q E + + LK+ KT ++ + + S EE L K K K IE+
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPV--SQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 994 LKESAEFQTQLEKKLMEVEKEK--------------QELQDD-------KRRAIESMEQQ 1032
++E+ + + Q + E+EK++ QELQ++ K +S +Q
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885
Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV-----EAQNKYERELM 1087
E K L ++ E+ LQR + + + D +++ +A E K ELM
Sbjct: 886 ELEYKSKLKALNEELH--LQRINPTTVKMKSSVFD-EDKTFVAETLEMGEVVEKDTTELM 942
Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147
E L+ K + +++ L E ++ ++ + E + LK E +
Sbjct: 943 ------EKLEVTKREKLELSQRLSDLSEQLKQKHGEI----SFLNEEVKSLKQEKEQVSL 992
Query: 1148 RCEDLE---KQNRLLH-----DQIEKLSDKVVASVKEGVQGPL----------------- 1182
RC +LE NR + Q+ L D VV G +G +
Sbjct: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
Query: 1183 -----NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQE 1237
N+++ EE K ++ IL+ L + +E + T+ E+ + ++ + +L+ E +
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ----PSENDKLQKELNVLKSEQND 1108
Query: 1238 LQDSLNAEREKVQVTAKT-MAQHEELMKKTETMNVVMETNKMLREEKERL----EQDLQQ 1292
L+ + A+R + + T + Q E M+ E +K L KE L E+ +++
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMEN--------EKDKALCSLKEELIFAQEEKIKE 1160
Query: 1293 MQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTE 1352
+Q K+ +LEL + QE E ++ +K + E+ +
Sbjct: 1161 LQ-KIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF----------------- 1202
Query: 1353 EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
+Q L +G + + + +N + E+ ++
Sbjct: 1203 ---------------LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDP 1240
Query: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVS 1472
+D ++ D QE + T+ + +Y +L Q ++ + Q +
Sbjct: 1241 ELQDYRYEVQDFQENMHTLLN------KVTEEYNKLLVLQTRLSKIWGQQTDG------- 1287
Query: 1473 VQEMQELKETLNQAETKSKSLESQVENLQ--------KTLSEKETEARNLQEQTVQLQSE 1524
+++ +E L + ET+ S+ SQ+ NL+ K S ++ E L+EQ +L+S
Sbjct: 1288 -MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESL 1346
Query: 1525 LSRLRQDLQD 1534
+S L+Q L++
Sbjct: 1347 ISSLQQQLKE 1356
Score = 135 bits (340), Expect = 5e-31
Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%)
Query: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800
R ++ EQ L +LA + E L +E E ++++ ++ Q
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194
Query: 801 QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858
+ E+ + ++ G LT NLQ Q E+ ET + L+ Q +KL+ + L+ E
Sbjct: 195 EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251
Query: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
H+ T LL K+Q+ T LL++ QK+ +S ++ ++
Sbjct: 252 RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308
Query: 919 SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970
++ K + SNKE+ +++L +++ + E++ +LK++L T+ + + Q +
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368
Query: 971 ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009
L S KE+Q +EE++ + ++ R + ++F+T + +++
Sbjct: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428
Query: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
++E+ + EL + + I M+Q+L +++++ + + E++ AL+ S NE Q
Sbjct: 429 KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
Query: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
+ + I ++ N + +L E L E+ + + L E +
Sbjct: 489 KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176
Q+ + + E+E L +E K + EDL+ + + ++L K A V E
Sbjct: 543 QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222
++ N L +SQE LE LR E+E++ E R + +++ +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273
Y+Q+++ L+ E+ + +++ E++ ++++ Q + K+E M + +
Sbjct: 662 HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721
Query: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322
E + +EEKE+ LEQ++Q++Q K LE + LQE A+L ++ +L+
Sbjct: 722 NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781
Query: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
EKK LE+ +K VSQ++ + K S+ V K I+ L EE LK
Sbjct: 782 DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833
Query: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Q IQ L E++ K R +K+ + ++QE+ + +VK K
Sbjct: 834 ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
Query: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497
+ E +LKA +++ + + V ++ + ETL E K +
Sbjct: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942
Query: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
E L+ T EK +L EQ Q E+S L ++++ ++EQ+ + E E
Sbjct: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998
Query: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
I+ ++ ++ Q++ LD +T EG +S++
Sbjct: 999 --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039
Query: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664
+ E + +E + + + +Q Q+ L P+ + + P
Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Score = 129 bits (324), Expect = 3e-29
Identities = 314/1499 (20%), Positives = 619/1499 (41%), Gaps = 195/1499 (13%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
LQQ L+ T NK+ ++ K E + D +++I+ L E K E++ ++ + +
Sbjct: 2304 LQQQLKITTDNKV---IEEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
Query: 65 QERLVN----ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Q+ L N + SL E + L +QL ++ +A++ Q EE+
Sbjct: 2360 QQELANIGQKTSMNAHSLSEEADSLKHQL----------DVVIAEKLALEQQVETANEEM 2409
Query: 121 EAEKRDLIRTN---ERLSQELEYLT---EDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
K L TN +L+QEL L E V+++ + + E++ L D+ + V
Sbjct: 2410 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKI-QSIPENSVNVAIDHLSKDKPELEVV 2468
Query: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-KCNLENKK-EE 232
+ K LE + + + + +T LL L + LEL +C + K +E
Sbjct: 2469 LTEDALKSLENQTYFKSFEENGKGSIINLET-RLLQLESTVSAKDLELTQCYKQIKDMQE 2527
Query: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE--KFHNELNA------HIK 284
+ E +M K N LQK VE+ + ++ Q +++E KF +
Sbjct: 2528 QGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2585
Query: 285 LSNLYKSAADDSEA-------KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
+ NL + D+ + + +EL V E+H L E + + ++LE E+ +
Sbjct: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
Query: 338 MEK--EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
++K E EK R +++ + D+ S EE + A A+ V +L
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2705
Query: 396 TELYNAYVETQDQLLLEKLENKRINKYLDEI---VKEVEAKAPILKRQRE-EYERAQKAV 451
+ Q++LL+++ + K L ++ + E + K IL+++ E E + ++KA
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2765
Query: 452 A--SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
L +KL ++ + TD K SS N+ +I VK+ QI L E
Sbjct: 2766 MFEPLPIKLSKS------IASQTDGTLKISS----SNQTPQILVKNAGIQIN-LQSECSS 2814
Query: 510 ARGNHVIRD--EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567
+I E++ ++E++ + R+I E + + VA++ L +E
Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILD---MESRHISETETLKREHYVAVQLL-----KE 2866
Query: 568 EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR-ILLSQTTGVAI 626
E T + I L+ K S++ EL S +Q + + S D + I L+ + G I
Sbjct: 2867 ECGTLKAVIQCLRSKEGSSIPELAH---SDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2923
Query: 627 PLHASSLDDVSLA-STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685
+ S S PK+ + V+ TE+ + +Q++ E + +E
Sbjct: 2924 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2983
Query: 686 KAE--------NEKIQNEQLEKLQEQVTDLRSQNT--------KISTQLDFASKRYEMLQ 729
+ + I QL++ E +S + ++ Q F +R +L
Sbjct: 2984 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3043
Query: 730 DNVEGYRREITSLHERNQK-----LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
+R E+T+L + L Q+Q + L+ A+ + ++E++A +
Sbjct: 3044 ----AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3099
Query: 785 KKEKEMLKLSEVRLSQQRESLLAE---QRGQNLLLTNLQTIQGILERSETETKQRLSSQ- 840
+ + L + S++ L E Q+ Q+ +L + + +R+ TE +++LSS+
Sbjct: 3100 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA-TELQEQLSSEK 3158
Query: 841 --IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898
+ +L+ E++ K +LE ++ +H + L+ L+ K + D +HL + L + Q
Sbjct: 3159 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD---EVHL-LNDTLASEQ 3214
Query: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
K+ L+ L + ++ G+ + +KE+++DL L +++ L L+
Sbjct: 3215 KKSRELQWALEKEKAKL--------GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3266
Query: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR-LKESAEFQTQLEKKLMEVEKEKQ- 1016
+ + Q + S + + + Q++EE +N+E++ L ES + + + ++ E+E
Sbjct: 3267 KQLLNESQQKIES--QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3324
Query: 1017 ELQDD-----------KRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE 1061
+LQ ++ +++QL E + + NE + ++LQ +
Sbjct: 3325 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3384
Query: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKA 1120
Q R+ Q + + E Q K EL D++ L+ ++QV K+ Q L+ Q+
Sbjct: 3385 QVHRKTLQTEQEANTEGQKKMH-ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
Query: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
+ Q LE + E R + ++ +N +L +IE KE
Sbjct: 3444 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE-------GETKESNYA 3496
Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
L + ++ G LE+ IR++ + ++ +V ++ E L+ E + +D
Sbjct: 3497 KL-IEMNGGGTGCNHELEM---IRQKLQCVASKLQVLP------QKASERLQFETADDED 3546
Query: 1241 SL----NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296
+ N + +Q+ T Q EE + + + T ++LR+ E
Sbjct: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAE------------ 3594
Query: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR-----NQHLVSQQKDPDT 1351
L ++L+E+ L+ LEE ++ ++ N S +
Sbjct: 3595 ----------LTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANI 3644
Query: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410
E + SEKEV + L + + R +AE+ + A L N +L+Q+L D V ++
Sbjct: 3645 EAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEHVTLKR 3700
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 180 bits (457), Expect = 1e-44
Identities = 265/1267 (20%), Positives = 529/1267 (41%), Gaps = 150/1267 (11%)
Query: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
LSV+L A +I+RL+++ ++ +Q +++ +MEI++K L Q+ LL + AR
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-- 306
Query: 514 HVIRDEEVSSADISSSSEVISQHLVSYRN-----------IEELQQQNQRLLVALRELGE 562
+ RDE + + + + + + Y+ +EEL++ NQ LL L +
Sbjct: 307 -MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 563 TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
+ E S K+ EL+ + +L + R + ++ ++ + + Q+
Sbjct: 366 --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 623 GVAIPLHASSLDDVS----LASTPKRP-------------------STSQTVSTPAPVPV 659
++ L L+ +S L+ P++ + S T +
Sbjct: 424 DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
++S E +K + + + K E ENE +Q +Q L+ Q DL + + I
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
T + + ++ ++L+ E + ++SL +R+Q A + E+ + + ++ + K
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
L+ E +KKE E K R + L ++ LL + ++ E+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660
Query: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
L + +LE E LKK L++ +NL QL ++ QLD E NL L
Sbjct: 661 ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLDEE-NLELRR 708
Query: 891 K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
E LK A ++A L+ L N E++ + ++ + ++ + + L + + +
Sbjct: 709 NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 950 DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
L++ L+ S ++Q LE L + + ++KN+E LK S++ QLEK+
Sbjct: 767 RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818
Query: 1010 EVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
+E+E +L+ DK++ + ++ Q +E+K T N L++ + LS E ++
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
+ K +E +NK EL+ A D++ L +E + Q + +K +L +
Sbjct: 879 SCVRLK-ELEKENK---ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
+ +ER+L DE S + + +LL ++E K + +KE L L
Sbjct: 935 IGLN---KERLLHDEQST--------DDRYKLLESKLESTLKKSL-EIKEEKIAALEARL 982
Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
E +Q+ + L+ +++ E+L+ RQ E + + + N
Sbjct: 983 EESTNYNQQLRQELKTVKKN------------YEALKQRQDEERMVQSSPPISGEDNKWE 1030
Query: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
+ Q T + + + ++ + + E N ++ K L+ + ++LE +QA++ L+ +
Sbjct: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
LQE N L ++ LQ E L +N L+ QQ + E ++ E+E
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1149
Query: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
L E++ L A SL + ++S ++L E +DL+ +
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1202
Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
+ ++ + ++K+ LK +Q+K++ + E E L T
Sbjct: 1203 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1252
Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
+Q +++ L++ +NL+ L+ + E L+ + +L+ + +L Q E L
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
Q EE+ R HL L +N L ++N + KD V
Sbjct: 1313 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1354
Query: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
+ QY +++ L R+ + +E+ ++Q P+ N + + R++ + ER
Sbjct: 1355 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1414
Query: 1658 IASTSDP 1664
+ T P
Sbjct: 1415 KSLTLTP 1421
Score = 152 bits (383), Expect = 5e-36
Identities = 346/1679 (20%), Positives = 684/1679 (40%), Gaps = 291/1679 (17%)
Query: 28 FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
FL S G + ES Q + + + ++ ++ L +T + + ELE
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 84 KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
++ +LK L ++N L + +D A++ + R ++LE+E + R ERL
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337
Query: 137 ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
++E+ E++K N+ L E+ T E QL KL EL+ ++ +K + +E
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
Query: 186 EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
E+++ L +N L K DE L LG E + +E+ E ++ EV
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454
Query: 234 SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
+ L ++ L+ N+ L K VE+L T + ++ E AS K E + +LS +
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510
Query: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
++ + L L+KE + K I E ++ E++ I LE+E
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559
Query: 353 LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
E+ N +S+ +++ I +E + ++ T++ ++KI
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 389 -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
+ G + EL N ++E +++LL +K+ N +I E ++ +E + L+R+ + +
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676
Query: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
+ + +L+ +LE KE +L E+ + A+ + + L+ +N+ +E + +
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 496 LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
L + + +L ++ V I ++ + +S+ ++ Q L S +++L+ +
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792
Query: 550 NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
NQ L L EL + +R EQ +K E + +LE +LE+ K + Q ++ D+ +
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 609 RQRDMYRILL---SQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
+ ++ L ++T I ++ S V L K E+ E
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESC--VRLKELEK-----------------ENKEL 893
Query: 666 IE-AKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
++ A +K L + E+ EK + +++ N+ LEKL ++ + ++ R
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDR 952
Query: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Y++L+ +E ++ SL + +K+ A + E+ N Q LR ++L + E L
Sbjct: 953 YKLLESKLESTLKK--SLEIKEEKIAALEARLEESTN-YNQQLR---QELKTVKKNYEAL 1006
Query: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
K+ ++ E R+ Q + E + +T + +L + K RL ++E+
Sbjct: 1007 KQRQD-----EERMVQSSPPISGEDNKWE--RESQETTRELL-----KVKDRL-IEVERN 1053
Query: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNAQKEIA 902
+ K+ L+ +++Q T NL Q+L +RQ + E N L T+ Q E +
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKLQVENS 1111
Query: 903 TLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
TL L N Q+ Q S + + +ED+ L L + E++ L ER
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER--- 1168
Query: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLMEVEKEK 1015
+Y++++ S +L + E +++E R + + + QLE +K+++VE+EK
Sbjct: 1169 ---QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
Query: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075
L++ + + ++L L N L + + L + + + +K+
Sbjct: 1225 MLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLNNSKL- 1279
Query: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLECKASWE 1132
Q + E E SK+ Q L+ T+ K +Q L + K + E
Sbjct: 1280 --EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320
Query: 1133 ERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDKVVASV 1174
E R L D++ + + L +QN L Q EKL +K++
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1380
Query: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
K P + L++ + I+ +K+I R + + R L+
Sbjct: 1381 KFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLP 1434
Query: 1235 LQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQ 1294
Q+ QDS + V + ++ + L K +M V ++ LR +D +M+
Sbjct: 1435 HQDSQDSSS-------VGSNSLEDGQTLGTKKSSM-VALKRLPFLRNR----PKDKDKMK 1482
Query: 1295 AKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ-------------- 1340
A R+ + + L ++ + +G E + +D+ K R +
Sbjct: 1483 ACYRR-SMSMNDLVQSMVLAGQWTG--STENLEVPDDISTGKRRKELGAMAFSTTAINFS 1539
Query: 1341 ------HLVSQQ--KDPDTEEYRKLLSE---------KEVHTKRIQQLTEEIGRLKAEIA 1383
S+Q + DT + + + VH R L + GR +
Sbjct: 1540 TVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL--DSGRTSTSNS 1597
Query: 1384 RSNASL-------TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK- 1435
+NASL NNQ+ QS + + E + I ++ + ++ ++
Sbjct: 1598 NNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQH 1657
Query: 1436 KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES 1495
KI ++++ ++K +G + V++Q+ E L + KS S E+
Sbjct: 1658 KISETLESRHHKIK-------------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQEN 1704
Query: 1496 QVENLQKTLSEKETEARNLQEQTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
++ + K+LS + + L +S + D DR T + + + K E T
Sbjct: 1705 LLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1763
Score = 145 bits (365), Expect = 6e-34
Identities = 236/1129 (20%), Positives = 473/1129 (41%), Gaps = 158/1129 (13%)
Query: 16 KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
K+ + ++ + +A +QS + L H +++E + E+ + S VNE
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
+ L+LE+E ++LT+ +EL D S+ + ++E N+RLS
Sbjct: 461 RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504
Query: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
+++E L ++ + + L+ +L + +L+ + +++ +R LEQE E L+
Sbjct: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
Query: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
+ L + E EK N+IL +++ ++S++E + +K EH
Sbjct: 565 QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620
Query: 252 KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
KE E+ +E + H NEL K++NL K + EA E +
Sbjct: 621 ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668
Query: 307 VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
E KL K+ ++ K + L +E+ Q+++E LE L + +E+ ++ K
Sbjct: 669 ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721
Query: 367 GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
L +EL + +++K K TE + D +EN+R+ K L+
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775
Query: 427 VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
K+++ L+ E + QK + L + + K +++L+++ +++S LE+D
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 487 RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
+++E + K L QQ + LEE V ++ ++ +S+ + Y+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 543 IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK--LESALTELEQLRKSRQ-- 598
++EL+++N+ L+ +T ++ S K+ Q+ LE ELE++ +++
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Query: 599 -HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
H Q D D Y++L S+ + ++ ST+ +
Sbjct: 943 LHDEQSTD------DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
Query: 658 PVIEST-EAIEAKAALKQLQEIF-----ENYKKEKAENEKIQ-----NEQLEKLQEQVTD 706
++ EA++ + +++ + E+ K E+ E + ++L +++
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN---QKLTATTQKQEQIINTM 763
L+++ + TQL + LQ + +R+ SL E+N Q A Q + +N+
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 764 TQDLRGANEKLAVAEVRAEN------------------LKKEKEMLKLSEVRLSQQRESL 805
+ L N +L + + EN L K+ E L+L R + + ESL
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Query: 806 LAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
+++ NL+ LE R KQ+ Q+E LE + ++K+ E + T
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLEKMLKVEQEKMLLENKNHET 1234
Query: 865 LTRNL------DVQLLDTKRQLDTETNL----HLNTKELLKNAQKEIATLKQHLSNMEVQ 914
+ + +L T QL ET + H N K LL N++ E L+ S ++ Q
Sbjct: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Query: 915 VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN-VEQYQAMV---- 969
+ +D ++L E ++ LK L+ + ++Q Q ++
Sbjct: 1295 Y----------------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR 1338
Query: 970 TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESM 1029
T LE+++ + E R+ I+ +L E + +LE+K+M+ K RR +
Sbjct: 1339 TLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMDQYKFYD--PSPPRRRGNWI 1395
Query: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARRDCQEQAKI 1074
++ +L K+ + E Q++L T + Q +D Q+ + +
Sbjct: 1396 TLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSV 1444
Score = 127 bits (318), Expect = 2e-28
Identities = 189/899 (21%), Positives = 395/899 (43%), Gaps = 120/899 (13%)
Query: 819 LQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV-----EQRHTLTRNLDVQL 873
++ IQG+ + +TK +++ I+++ H ++ EV E L +N+ + L
Sbjct: 142 IERIQGL----DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197
Query: 874 LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
KR +D E + H T L + + L S+ + S +RT Q + E
Sbjct: 198 ---KRLID-ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE- 252
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEE---SLNKEKQVTEEVRKNI 990
+ D +++R+ +++ + E+L +EQ + + L++ +L + + R +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 991 EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA 1050
+ L+E A +++K EV + K+ L D IE + ++ ELK E +
Sbjct: 313 DA-LREKA---VRVDKLESEVSRYKERLHD-----IEFYKARVEELK--------EDNQV 355
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR 1110
L T L ++ + R ++ +E +N + + LH ++E ++++ ++
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLH-ELEKEN-LQLKAKLHDMEMER-DMDRKKIEELMEEN 412
Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
LE +++ + L WE + E+S+ Q L H+ E S ++
Sbjct: 413 MTLEMAQKQSMDESLHL--GWELEQISRTSELSEA--------PQKSLGHEVNELTSSRL 462
Query: 1171 VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVEL 1230
+ L E +S + +E LR E ++ + E+ R ++VE+
Sbjct: 463 L-------------KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1231 LEREL-QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETN-KMLREEKERLEQ 1288
LE E+ QE Q N + ++ M + +L K ET+ E K+L +E E L Q
Sbjct: 510 LENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 1289 DLQQM--------QAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
+ + +A+V+ +E + L E+ E S K ++ EK+ ++++++ +K + +
Sbjct: 566 TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 1341 HLVSQQKD-----PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNL 1395
+ + + E +K ++ ++ ++I+ L +E L+ E + +L + +NL
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 1396 ---IQSLKEDLNKVRTEKETIQKDLDA------KIIDIQEKVKTITQVK----------- 1435
++SL+++ +++ E +++++++ K+ +Q + K + K
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
Query: 1436 ---KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
K R + Y+ L + ++ +T S+ Q+ +Q+++ +TL + + K
Sbjct: 746 ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805
Query: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ--DLQDRTTQEEQLRQQITEKE 1550
++E L+K E E L++ QL+ E RLRQ +++D T +E ++ EKE
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 1551 EKT-RKAIVAAKSKIAHLAGVKDQLTKENEELKQR-----NGALDQQKDELDVRITALKS 1604
KT K I K L +L KEN+EL +R + ++D + ++
Sbjct: 866 NKTLSKEIGIYKESCVRL----KELEKENKELVKRATIDIKTLVTLREDLVSEKLKT--Q 919
Query: 1605 QYEGRISRLERELRE---HQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIAS 1660
Q + +L EL + ++ER L ++ + K+ E + + TLK + E IA+
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 180 bits (456), Expect = 2e-44
Identities = 265/1267 (20%), Positives = 529/1267 (41%), Gaps = 149/1267 (11%)
Query: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
LSV+L A +I+RL+++ ++ +Q +++ +MEI++K L Q+ LL + AR
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-- 306
Query: 514 HVIRDEEVSSADISSSSEVISQHLVSYRN-----------IEELQQQNQRLLVALRELGE 562
+ RDE + + + + + + Y+ +EEL++ NQ LL L +
Sbjct: 307 -MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 563 TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
+ E S K+ EL+ + +L + R + ++ ++ + + Q+
Sbjct: 366 --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 623 GVAIPLHASSLDDVS----LASTPKRP-------------------STSQTVSTPAPVPV 659
++ L L+ +S L+ P++ + S T +
Sbjct: 424 DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
++S E +K + + + K E ENE +Q +Q L+ Q DL + + I
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
T + + ++ ++L+ E + ++SL +R+Q A + E+ + + ++ + K
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
L+ E +KKE E K R + L ++ LL + ++ E+ E
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660
Query: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
L + +LE E LKK L++ +NL QL ++ QLD E NL L
Sbjct: 661 ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLDEE-NLELRR 708
Query: 891 K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
E LK A ++A L+ L N E++ + ++ + ++ + + L + + +
Sbjct: 709 NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 950 DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
L++ L+ S ++Q LE L + + ++KN+E LK S++ QLEK+
Sbjct: 767 RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818
Query: 1010 EVEKEKQELQDDKRRAIESMEQ--QLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
+E+E +L+ DK++ + ++ Q +E+K T N L++ + LS E ++
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
+ K +E +NK EL+ A D++ L +E + Q + +K +L +
Sbjct: 879 SCVRLK-ELEKENK---ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
+ +ER+L DE S + + +LL ++E K + +KE L L
Sbjct: 935 IGLN---KERLLHDEQSTD-------DSRYKLLESKLESTLKKSL-EIKEEKIAALEARL 983
Query: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
E +Q+ + L+ +++ E+L+ RQ E + + + N
Sbjct: 984 EESTNYNQQLRQELKTVKKN------------YEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
+ Q T + + + ++ + + E N ++ K L+ + ++LE +QA++ L+ +
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
LQE N L ++ LQ E L +N L+ QQ + E ++ E+E
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1150
Query: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
L E++ L A SL + ++S ++L E +DL+ +
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1203
Query: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
+ ++ + ++K+ LK +Q+K++ + E E L T
Sbjct: 1204 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
+Q +++ L++ +NL+ L+ + E L+ + +L+ + +L Q E L
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
Query: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
Q EE+ R HL L +N L ++N + KD V
Sbjct: 1314 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1355
Query: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
+ QY +++ L R+ + +E+ ++Q P+ N + + R++ + ER
Sbjct: 1356 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1415
Query: 1658 IASTSDP 1664
+ T P
Sbjct: 1416 KSLTLTP 1422
Score = 160 bits (405), Expect = 1e-38
Identities = 338/1658 (20%), Positives = 669/1658 (40%), Gaps = 276/1658 (16%)
Query: 28 FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
FL S G + ES Q + + + ++ ++ L +T + + ELE
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
Query: 84 KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
++ +LK L ++N L + +D A++ + R ++LE+E + R ERL
Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337
Query: 137 ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
++E+ E++K N+ L E+ T E QL KL EL+ ++ +K + +E
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
Query: 186 EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
E+++ L +N L K DE L LG E + +E+ E ++ EV
Sbjct: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454
Query: 234 SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
+ L ++ L+ N+ L K VE+L T + ++ E AS K E + +LS +
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510
Query: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
++ + L L+KE + K I E ++ E++ I LE+E
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559
Query: 353 LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
E+ N +S+ +++ I +E + ++ T++ ++KI
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 389 -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
+ G + EL N ++E +++LL +K+ N +I E ++ +E + L+R+ + +
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676
Query: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
+ + +L+ +LE KE +L E+ + A+ + + L+ +N+ +E + +
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 496 LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
L + + +L ++ V I ++ + +S+ ++ Q L S +++L+ +
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792
Query: 550 NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
NQ L L EL + +R EQ +K E + +LE +LE+ K + Q ++ D+ +
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668
+ ++V + + K T S E
Sbjct: 853 EE-----------------------NNVKIGNLEKENKTL-------------SKEIGIY 876
Query: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
K + +L+E+ E KE + I + L L+E + + + +++ L+ + E +
Sbjct: 877 KESCVRLKEL-EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 729 QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
N E + S + KL + ++ +T+ + L EK+A E R E
Sbjct: 936 GLNKERLLHDEQSTDDSRYKLL-----ESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
Query: 789 EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG---ILERSETETKQRLSS------ 839
+ L+ E++ ++ L +++ + ++ + I G ER ET + L
Sbjct: 991 QQLR-QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 840 QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNA 897
++E+ + K+ L+ +++Q T NL Q+L +RQ + E N L T+
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKL 1107
Query: 898 QKEIATLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLK 952
Q E +TL L N Q+ Q S + + +ED+ L L + E++ L
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167
Query: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLME 1010
ER +Y++++ S +L + E +++E R + + + QLE +K+++
Sbjct: 1168 ER------QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220
Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
VE+EK L++ + + ++L L N L + + L + + +
Sbjct: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLN 1276
Query: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLEC 1127
+K+ Q + E E SK+ Q L+ T+ K +Q L +
Sbjct: 1277 NSKL---EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQL 1316
Query: 1128 KASWEERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDK 1169
K + EE R L D++ + + L +QN L Q EKL +K
Sbjct: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Query: 1170 VVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVE 1229
++ K P + L++ + I+ +K+I R + + R
Sbjct: 1377 IMDQYKFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEG 1430
Query: 1230 LLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE---EKERL 1286
L+ Q+ QDS + ++ +T+ KK+ TMN ++++ + + E L
Sbjct: 1431 FLQLPHQDSQDSSSVGSNSLE-DGQTLG-----TKKSSTMNDLVQSMVLAGQWTGSTENL 1484
Query: 1287 EQDLQQMQAKVRKLELDILPLQEA--NAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
E K RK EL + N S ++++ + +D ++ + VS
Sbjct: 1485 EVPDDISTGKRRK-ELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVS 1543
Query: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL-------TNNQNLIQ 1397
+ VH R L + GR + +NASL NNQ+ Q
Sbjct: 1544 DDSS----------TGSRVHASRPASL--DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQ 1591
Query: 1398 SLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK-KIGRRYKTQYEELKAQQDKVM 1456
S + + E + I ++ + ++ ++ KI ++++ ++K
Sbjct: 1592 SHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIK------- 1644
Query: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
+G + V++Q+ E L + KS S E+ ++ + K+LS +
Sbjct: 1645 ------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKP 1698
Query: 1517 QTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
+ L +S + D DR T + + + K E T
Sbjct: 1699 VSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1736
Score = 146 bits (369), Expect = 2e-34
Identities = 240/1148 (20%), Positives = 480/1148 (41%), Gaps = 195/1148 (16%)
Query: 16 KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
K+ + ++ + +A +QS + L H +++E + E+ + S VNE
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
+ L+LE+E ++LT+ +EL D S+ + ++E N+RLS
Sbjct: 461 RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504
Query: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
+++E L ++ + + L+ +L + +L+ + +++ +R LEQE E L+
Sbjct: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
Query: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
+ L + E EK N+IL +++ ++S++E + +K EH
Sbjct: 565 QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620
Query: 252 KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
KE E+ +E + H NEL K++NL K + EA E +
Sbjct: 621 ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668
Query: 307 VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
E KL K+ ++ K + L +E+ Q+++E LE L + +E+ ++ K
Sbjct: 669 ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721
Query: 367 GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
L +EL + +++K K TE + D +EN+R+ K L+
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775
Query: 427 VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
K+++ L+ E + QK + L + + K +++L+++ +++S LE+D
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 487 RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
+++E + K L QQ + LEE V ++ ++ +S+ + Y+
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 543 IEELQQQNQRL----------LVALRE-------------------------LGETRER- 566
++EL+++N+ L LV LRE +G +ER
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Query: 567 --EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV 624
+EQ T S+ L+ KLES L + ++ ++ ++ +++ + + Y L Q
Sbjct: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEI---KEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 625 AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKK 684
+ + +R + V + P+ ++ E++ ++L ++ + +
Sbjct: 1000 V---------KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 685 EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHE 744
+ N +Q E+ + L+ Q+ L +QN + Q+ ++ LQ+ + T+L
Sbjct: 1051 VERNNATLQAEK-QALKTQLKQLETQNNNLQAQILALQRQTVSLQE-------QNTTLQT 1102
Query: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN------------------LKK 786
+N KL Q + +N+ + L N +L + + EN L K
Sbjct: 1103 QNAKL----QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
Query: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLE 845
+ E L+L R + + ESL+++ NL+ LE R KQ+ Q+E LE
Sbjct: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLE 1216
Query: 846 HEISHLKKKLENEVEQRHTLTRNL------DVQLLDTKRQLDTETNL----HLNTKELLK 895
+ ++K+ E + T+ + +L T QL ET + H N K LL
Sbjct: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276
Query: 896 NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERL 955
N++ E L+ S ++ Q + +D ++L E ++ LK L
Sbjct: 1277 NSKLEQTRLEAEFSKLKEQY----------------QQLDITSTKLNNQCELLSQLKGNL 1320
Query: 956 KTSTSN-VEQYQAMV----TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
+ + ++Q Q ++ T LE+++ + E R+ I+ +L E + +LE+K+M+
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMD 1379
Query: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARR 1066
K RR + ++ +L K+ + E Q++L T + Q +
Sbjct: 1380 QYKFYD--PSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
Query: 1067 DCQEQAKI 1074
D Q+ + +
Sbjct: 1438 DSQDSSSV 1445
Score = 130 bits (327), Expect = 2e-29
Identities = 189/899 (21%), Positives = 393/899 (43%), Gaps = 119/899 (13%)
Query: 819 LQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV-----EQRHTLTRNLDVQL 873
++ IQG+ + +TK +++ I+++ H ++ EV E L +N+ + L
Sbjct: 142 IERIQGL----DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197
Query: 874 LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
KR +D E + H T L + + L S+ + S +RT Q + E
Sbjct: 198 ---KRLID-ERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE- 252
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEE---SLNKEKQVTEEVRKNI 990
+ D +++R+ +++ + E+L +EQ + + L++ +L + + R +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 991 EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA 1050
+ L+E A +++K EV + K+ L D IE + ++ ELK E +
Sbjct: 313 DA-LREKA---VRVDKLESEVSRYKERLHD-----IEFYKARVEELK--------EDNQV 355
Query: 1051 LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVR 1110
L T L ++ + R ++ +E +N + + LH ++E ++++ ++
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLH-ELEKEN-LQLKAKLHDMEMER-DMDRKKIEELMEEN 412
Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
LE +++ + L WE + E+S+ Q L H+ E S ++
Sbjct: 413 MTLEMAQKQSMDESLHL--GWELEQISRTSELSEA--------PQKSLGHEVNELTSSRL 462
Query: 1171 VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVEL 1230
+ L E +S + +E LR E ++ + E+ R ++VE+
Sbjct: 463 L-------------KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1231 LEREL-QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETN-KMLREEKERLEQ 1288
LE E+ QE Q N + ++ M + +L K ET+ E K+L +E E L Q
Sbjct: 510 LENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ 565
Query: 1289 DLQQM--------QAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
+ + +A+V+ +E + L E+ E S K ++ EK+ ++++++ +K + +
Sbjct: 566 TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 1341 HLVSQQKD-----PDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNL 1395
+ + + E +K ++ ++ ++I+ L +E L+ E + +L + +NL
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 1396 ---IQSLKEDLNKVRTEKETIQKDLDA------KIIDIQEKVKTITQVK----------- 1435
++SL+++ +++ E +++++++ K+ +Q + K + K
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
Query: 1436 ---KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
K R + Y+ L + ++ +T S+ Q+ +Q+++ +TL + + K
Sbjct: 746 ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805
Query: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ--DLQDRTTQEEQLRQQITEKE 1550
++E L+K E E L++ QL+ E RLRQ +++D T +E ++ EKE
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 1551 EKT-RKAIVAAKSKIAHLAGVKDQLTKENEELKQR-----NGALDQQKDELDVRITALKS 1604
KT K I K L +L KEN+EL +R + ++D + ++
Sbjct: 866 NKTLSKEIGIYKESCVRL----KELEKENKELVKRATIDIKTLVTLREDLVSEKLKT--Q 919
Query: 1605 QYEGRISRLERELRE---HQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIAS 1660
Q + +L EL + ++ER L + K+ E + + TLK + E IA+
Sbjct: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 177 bits (450), Expect = 8e-44
Identities = 239/1195 (20%), Positives = 507/1195 (42%), Gaps = 161/1195 (13%)
Query: 389 VKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE-------IVKEVEAKAPILKRQR 441
VKP +++T ++LL K + ++ L+E +++E A L+ +
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 442 EEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501
E + A++ A L+ K ++ + + L+ ++ +++ +L+ + ++M+ ++DL +Q+
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL- 959
Query: 502 VLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELG 561
+ EE + ++ + A I E I L+ QN + + ++L
Sbjct: 960 ----DEEEGARQKLQLEKVTAEAKIKKMEEEILL----------LEDQNSKFIKE-KKLM 1004
Query: 562 ETRERE------EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR 615
E R E E+E + + +++ K E +++LE+ K + Q ++ R+ D
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD--- 1061
Query: 616 ILLSQTTGVA--IPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI----EAK 669
+TT + I + +D++ L K+ Q + A+ E +
Sbjct: 1062 ---GETTDLQDQIAELQAQIDELKL-QLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 670 AALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
A + +LQE FE+ K + + EK + + E+L+ T+L + Q + +KR + +
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKE 789
+ + E T HE A Q Q T ++L +E+L A+ NL+K K+
Sbjct: 1178 ELKKALEEE-TKNHE------AQIQDMRQRHATALEEL---SEQLEQAKRFKANLEKNKQ 1227
Query: 790 MLKLS------EVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
L+ EV++ QQ ++ +R + L +Q + + + + L+ + K
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKK--LDAQVQELHAKVSEGD-RLRVELAEKASK 1284
Query: 844 LEHEISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
L++E+ ++ LE ++ ++ L+ QL DT+ L ET LN ++ ++E
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
+L++ Q +E +L Q+ + Q+ D K+++
Sbjct: 1345 KNSLQEQ-------------------QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385
Query: 961 NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ- 1019
+E SLEE+ K + E + + RL+E A +LEK +++E +L
Sbjct: 1386 TIE-------SLEEAKKKLLKDAEALSQ----RLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 1020 --DDKRRAIESMEQQLSELKKTLS---SVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
D +R+ ++E++ + + L+ S+ E RA ++ +
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
A+EA+ ++ER+ AD+E L ++K+ V K LE++ + E Q+ E + EE
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV---HELEKSKRALEQQVEEMRTQLEE- 1550
Query: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
L+DE+ LE + + Q E+ ++ +E ++
Sbjct: 1551 ---LEDELQATEDAKLRLEVNMQAMKAQFER-----------------DLQTRDEQNEEK 1590
Query: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
+ L I + E E+ + R + A + + + ++L + E Q ++ + A E ++ K
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ-IEAANKARDEVIKQLRK 1649
Query: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
AQ ++ ++ E R ++ + ++ + K++ LE +IL LQE A
Sbjct: 1650 LQAQMKDYQRELEEA----------RASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT------EEYRKLLSEKEVHTKRI 1368
+ E+ L +++ + L+ +++ + EE + S E+ R
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ-----------KDL 1417
++ T ++ L AE+A ++ + N Q L+ +++ + + ++ L
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 1418 DAKIIDIQEKV----KTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
+AKI ++E++ K K+ RR + + +E+ Q +E + + ++EQ
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKA 1875
Query: 1474 Q-EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR 1527
M++LK L +AE ++ + LQ+ L + L + L++ L R
Sbjct: 1876 NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 174 bits (440), Expect = 1e-42
Identities = 237/1220 (19%), Positives = 501/1220 (41%), Gaps = 192/1220 (15%)
Query: 89 LKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRL 148
L +T + +EL+ + + ++ + T+ + ELE ++ R +++L +E L E ++
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELE----EMERKHQQLLEEKNILAEQLQAE 899
Query: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL 208
E E+ + L K EL+ ++ R + E+ ++L ++ + ++ ++L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 209 LALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQ 268
E+ +L+ + ++ ++EE++ L+ N K + + ++ E Q
Sbjct: 960 ----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 269 ASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
A EEK N K+ N + D E + + + +EL K ++ +QD +
Sbjct: 1016 AEEEEKAKN----LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 329 LEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKI 388
E++ D+++ ++ +K L+ L +D T K L K+
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDD---ETLHKNNAL----------------KV 1112
Query: 389 VKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQ 448
V+ EL E Q+ EK + K ++ +E+EA LK + E+
Sbjct: 1113 VR------ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA----LKTELEDTLDTT 1162
Query: 449 KAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE 508
A L K EQ + E+++ LE + + E Q++D+ Q+ L EL
Sbjct: 1163 AAQQELRTKREQEVAELKK-------------ALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 509 EARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE 568
E + + A++ +N + L+ N+ L ++ L + + E
Sbjct: 1210 EQ-----LEQAKRFKANLE-------------KNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 569 --QETTSSKITELQLKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTG 623
++ +++ EL K+ + EL + Q+++ V +++ + ++ G
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE--------AEKKG 1303
Query: 624 VAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYK 683
+ A+SL+ + T + + E+ + + + ++QL+E + +
Sbjct: 1304 IKFAKDAASLES-------QLQDTQELLQE-------ETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 684 KEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLH 743
+++ E E E + L++QV L+SQ ++D E L++ + ++ +L
Sbjct: 1350 EQQEEEE----EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 744 ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML-------KLSEV 796
+R ++ K E+ N + Q+L L A NL+K+++ K
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 797 RLSQQRESLLAEQRGQNLLLTNL-QTIQGILE------------RSETETKQRLSSQIEK 843
R +++R+ AE R + +L + ++ LE R++ E + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 844 LEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT 903
HE+ K+ LE +VE+ T L+ +L T+ D + L +N + + ++++ T
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATE---DAKLRLEVNMQAMKAQFERDLQT 1582
Query: 904 LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE 963
+ N+E L+ Q+R+ E ++ D +++ + ++ +
Sbjct: 1583 RDE----------------------QNEEKKRLLIKQVRELEAELEDERKQRALAVASKK 1620
Query: 964 QYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKR 1023
+ + + LE + + +EV K + +KL K+ Q ++ R
Sbjct: 1621 KMEIDLKDLEAQIEAANKARDEVIKQL---------------RKLQAQMKDYQRELEEAR 1665
Query: 1024 RAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNK-- 1081
+ + + Q E +K L S++ E+ LQ S+E+ R QE+ ++A E N
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEI---LQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 1082 -----YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
+ + L A + + +E+ S M + +TT + ++ E A ER
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA---ERSA 1779
Query: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSD------KVVASVKEGVQGPLNVSLSEEG 1190
K + ++ + LE+QN+ L ++++L K S E G L L +E
Sbjct: 1780 AQKSDNAR-----QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 1191 KSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQRVELLERELQELQDSL-NAERE 1247
K + +++R R EK++ E +V + + +Y++++E +++L+ L AE E
Sbjct: 1835 KERAAANKLVR--RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 1248 KVQVTAKTMAQHEELMKKTE 1267
+ A EL TE
Sbjct: 1893 ATRANASRRKLQRELDDATE 1912
Score = 173 bits (438), Expect = 2e-42
Identities = 233/1170 (19%), Positives = 488/1170 (41%), Gaps = 146/1170 (12%)
Query: 528 SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE-TREREEQETTSS---KITELQLKL 583
S+ +V+ ++ +Y + Q R+ ++ L + TR+ EE + K+ E Q K+
Sbjct: 814 SALKVLQRNCAAYLKLRHWQWW--RVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKV 871
Query: 584 ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
E L E+E R+HQ L + + +L++ L A + + + + K
Sbjct: 872 EGELEEME-----RKHQQLLEE---------KNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 644 RPSTSQTVSTPAPVPVIESTEAI---EAKAALKQLQEIFENYKKEKAENEKIQNEQ---- 696
+ + V E I E K +Q++ E +E+ +K+Q E+
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 697 --LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
++K++E++ L QN+K K ++++D + ++ E+ + L
Sbjct: 978 AKIKKMEEEILLLEDQNSKFI-------KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
KQE +I+ + E+L E + L+K K L L Q L A+ L
Sbjct: 1031 KQEVMISDL-------EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 815 LLTNLQT-IQGILERSETET--KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RN 868
L + +QG L R + ET K + +L+ +I+ L++ E+E R+ R+
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 869 LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
L +L K +L+ + +EL ++E+A LK+ L
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE------------------ 1185
Query: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
+ + E Q+ D+++R T+ + + + +L K KQ E K
Sbjct: 1186 -----------ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQ----DDKRRAIESMEQQLSELKKTLSSVQ 1044
+ +K + + + E K +++ + QEL + R +E + ++ S+L+ L +V
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-LAEKASKLQNELDNVS 1293
Query: 1045 NEVQEALQR----ASTALSNEQQAR-------RDCQEQAKIAVEAQNKYERELMLHAADV 1093
++EA ++ A A S E Q + + +++ ++ + E + L
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD------EVSKCVC 1147
E +A K ++ +++ L +T +K + L ++ E ++++LKD + +
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 1148 RCEDLEKQNRLLHDQIEKLS-----DKVVASVKEGVQGPLNVSLSEEGKSQEQILEI--- 1199
+ LEK L +++ L+ + VAS E Q + L+EE + E
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Query: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ------------------ELQDS 1241
REKE A E+L ++ E ++L+ EL+ S
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533
Query: 1242 LNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM-QAKVRKL 1300
A ++V+ + + E+ ++ TE + +E N ++ K + E+DLQ + K
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN--MQAMKAQFERDLQTRDEQNEEKK 1591
Query: 1301 ELDILPLQEANAELSEKS---GMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL 1357
L I ++E AEL ++ + A KK +E D+K +A+ + ++ +D ++ RKL
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE-AANKARDEVIKQLRKL 1650
Query: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
++ + + + +++ + A+ S L + + I L+E+L + +++
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 1418 DAKIIDIQE----KVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
D +I K + + +++ R EEL+ +Q + + + +
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ-LQSELSRLRQDL 1532
E+ + +++ + LE Q + L+ L E E ++ + T+ L++++ +L + L
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL 1830
Query: 1533 QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQK 1592
+ + + + E+K ++ + + + H K+Q+ K N +KQ L++ +
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 1593 DELDVRITALKSQYEGRISRLERELREHQE 1622
+E A ++ R +L+REL + E
Sbjct: 1891 EE------ATRANASRR--KLQRELDDATE 1912
Score = 169 bits (427), Expect = 4e-41
Identities = 234/1126 (20%), Positives = 488/1126 (43%), Gaps = 132/1126 (11%)
Query: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
QQ+LE E N L + +Q + E F +E + ++ R K E E+ ++E R+ +
Sbjct: 883 QQLLE--EKNILAEQLQAETELF-----AEAEEMRARLAAKKQELEEILHDLESRVEEEE 935
Query: 66 ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDR----NIAIQSQFTRTKEE-- 119
ER Q L+ E +K+ ++ L E+ E E A+ + + +++ + +EE
Sbjct: 936 ERN-------QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL 988
Query: 120 -LEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
LE + I+ + + + + + EK K + + ++ + +L+ +
Sbjct: 989 LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
+ LE+ K L + T L ++I EL+ ++ K ++++ EE
Sbjct: 1049 TRQELEKAKRKLDGETTDLQ------------------DQIAELQAQIDELKLQLAKKEE 1090
Query: 239 QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
++ G + H + L ++E + Q A ++E F +E + K + +++ EA
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 299 KSNEL------TRAVEELH-KLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
EL T A +EL K +E E KA+++ E M + + L +
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210
Query: 352 ELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
+LE A + ++ +++ L + A K+++ +E ++ Q Q L
Sbjct: 1211 QLEQAKRFKANLEK-----NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 412 EKL-ENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQR-LQ 469
K+ E R+ L E +++ + + EE E+ A + LE +++ Q LQ
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 470 EDT-DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
E+T K N S + R++E + L +Q E EEAR N + + + ++
Sbjct: 1326 EETRQKLNLSSRI-----RQLEEEKNSLQEQQE----EEEEARKN-LEKQVLALQSQLAD 1375
Query: 529 SSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALT 588
+ + + L IE L++ ++LL L ++ EE+ K+ + + +L+
Sbjct: 1376 TKKKVDDDL---GTIESLEEAKKKLLKDAEAL--SQRLEEKALAYDKLEKTKNRLQQ--- 1427
Query: 589 ELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTS 648
EL+ L HQ Q+ ++ +++ + LL++ ++ A ++ A R +
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS----ARYAEERDRAEAEAREKET 1483
Query: 649 QTVSTPAPVPVIESTEAIEAKAAL----KQLQEIFENYKKEKAENEKIQNEQLEK----L 700
+ +S + EA+EAK KQL+ E+ K + K +E LEK L
Sbjct: 1484 KALSLARAL-----EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRAL 1537
Query: 701 QEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEG----YRREITSLHERNQKLTATTQKQ 756
++QV ++R+Q ++ +L L+ N++ + R++ + E+N++ KQ
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597
Query: 757 EQIINTMTQDLRGANEKLAVA-----EVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
+ + +D R LAVA E+ ++L+ + E + + +Q L A+ +
Sbjct: 1598 VRELEAELEDER-KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 812 QNLLLTNLQTIQGILERSETETKQRLSS---QIEKLEHEISHLKKKLENEVEQRHTLTRN 868
L + + + E++++L S +I +L+ E++ ++ + ++R L
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716
Query: 869 L------DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQR 922
+ LLD KR+L+ +E L+ Q + L +QV + +++
Sbjct: 1717 ITNSASGKSALLDEKRRLEARI---AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAEL 1773
Query: 923 TGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESLNK-EK 980
+ + K D + +Q E Q +LK +L+ V+ +++A +++LE + + E+
Sbjct: 1774 AAERSAAQKSD-----NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828
Query: 981 QVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL 1040
Q+ +E ++ + + EKKL E+ + +D+RR + ++Q+ + +
Sbjct: 1829 QLEQEAKERAAAN-----KLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKANARM 1879
Query: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL 1086
++ +++EA + A+ A +RR Q + A EA RE+
Sbjct: 1880 KQLKRQLEEAEEEATRA----NASRRKLQRELDDATEANEGLSREV 1921
Score = 155 bits (392), Expect = 4e-37
Identities = 234/1194 (19%), Positives = 496/1194 (41%), Gaps = 167/1194 (13%)
Query: 196 WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE 255
W + TK LL + R++ L+ K EE+ +++E+ ++ E +++ +
Sbjct: 832 WQWWRVFTKVKPLLQVTRQEEE--------LQAKDEELLKVKEKQTKVEGELEEMERKHQ 883
Query: 256 DLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK 315
LL + EQ + E F +L+ AK EL + +L ++
Sbjct: 884 QLLEEKNILAEQLQAETELFAEAEEMRARLA-----------AKKQELEEILHDLESRVE 932
Query: 316 EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK-ELENANDLLSATKRKGAILSEEE 374
E E N+ +Q+ +++ +E+++ E+ G +K +LE
Sbjct: 933 EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT----------------- 975
Query: 375 LAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKA 434
A AKI K ++++LL + +N +K++ E K +E +
Sbjct: 976 ---------AEAKIKK--------------MEEEILLLEDQN---SKFIKE-KKLMEDRI 1008
Query: 435 PILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK 494
Q E E K +A + K E + + L+E K K LE+ R+++ +
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 495 DLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLL 554
DL QI L +++E + ++EE+ A E + ++ + + + ELQ Q L
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN-ALKVVRELQAQIAELQ 1124
Query: 555 V------ALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIV 608
A R E ++R+ E + TEL+ L++ + E K Q +L ++
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVS---------LASTPKRPSTSQTVSTP--APV 657
+ + + HA++L+++S A+ K +T + V
Sbjct: 1185 EETKNHEAQIQDMR----QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 658 PVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ 717
V++ +A E++ K+L + + +E ++++ E L E+ + L+++ +ST
Sbjct: 1241 KVLQQVKA-ESEHKRKKLDAQVQELHAKVSEGDRLRVE----LAEKASKLQNELDNVSTL 1295
Query: 718 LDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVA 777
L+ A K+ + ++ E Q+ T I + ++ E+
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 778 EVRAENLKKE----KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSET-- 831
E +NL+K+ + L ++ ++ ++ + + + LL + + + LE
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 832 ----ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887
+TK RL +++ L ++ H ++ N +++ + L + + R +
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 888 LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQ 947
+E KE L + E A + +R K + D++DL+S +
Sbjct: 1476 AEARE------KETKALSLARALEEALEAKEEFERQNK---QLRADMEDLMSSKDDVGKN 1526
Query: 948 VNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKE-SAEFQTQLEK 1006
V++L++ + VE+ M T LEE L E Q TE+ + +EV ++ A+F+ L+
Sbjct: 1527 VHELEKSKRALEQQVEE---MRTQLEE-LEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582
Query: 1007 KLMEVEKEKQ-----------ELQDD-KRRAI-----ESMEQQLSELKKTLSSVQNEVQE 1049
+ + E++K+ EL+D+ K+RA+ + ME L +L+ + + E
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 1050 ALQRASTALSNEQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
+++ + + +R+ +E ++ + AQ+K E E L + + E LQ +E+++
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK-ESEKKLKSLEAEILQL-QEELASSE 1700
Query: 1108 SVRQHLEETTQKAESQLLEC---KASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIE 1164
R+H E+ + ++ K++ + +R L+ +++ E+ + LL+D+
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE-KEIAETRFEVAQVESLR 1223
K + +V LN L+ E + ++ + + R+ KE+ E+ +
Sbjct: 1761 KTTLQV---------DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Query: 1224 YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKT---------------ET 1268
++ + LE ++ +L++ L E ++ K + + E+ +K+ E
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871
Query: 1269 MNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQ 1322
M K L+ + E E++ + A RKL+ ++ EAN LS + L+
Sbjct: 1872 MEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925
Score = 128 bits (322), Expect = 6e-29
Identities = 188/828 (22%), Positives = 345/828 (41%), Gaps = 149/828 (17%)
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEV- 992
V L+ RQ EE +E LK E+ + LEE K +Q+ EE KNI
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVK----EKQTKVEGELEEMERKHQQLLEE--KNILAE 894
Query: 993 RLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ 1052
+L+ E + E+ + +KQEL++ +ES ++ E + L + + ++Q +Q
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHD-LESRVEEEEERNQILQNEKKKMQAHIQ 953
Query: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERE--LMLHAADVEALQAAKEQVSKMASVR 1110
L E+ AR+ Q + K+ EA+ K E L+L + + ++ K ++A
Sbjct: 954 DLEEQLDEEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 1111 QHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170
L E +KA++ L + + E L++ + K ++LEK R L + L D++
Sbjct: 1013 SQLAEEEEKAKN-LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 1171 -------------VASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVA 1217
+A +E +QG L +E + L+++R + + +IAE + +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARG-DDETLHKNNALKVVREL--QAQIAELQEDFE 1128
Query: 1218 QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNK 1277
++ R + E++ ++L + L A + +++ T T A +EL K E V E K
Sbjct: 1129 SEKASRNKA-----EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE--QEVAELKK 1181
Query: 1278 MLREEKERLEQDLQQMQAK----VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333
L EE + E +Q M+ + + +L + + A L + L+ + K L +VK
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 1334 RWKARNQHLVSQQKDPDTEEYRKLLSEK--EVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
V QQ ++E RK L + E+H K E RL+ E+A + L N
Sbjct: 1242 ---------VLQQVKAESEHKRKKLDAQVQELHAK-----VSEGDRLRVELAEKASKLQN 1287
Query: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451
+ + +L E+ K + L++++ D QE ++ T+ K Q EE K
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511
+ E ++ + ++Q +++Q +L +T + + ++ES E +K L + E +
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQS--QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 1512 RNLQEQTV---QLQSELSRLRQDLQDRTTQEEQLRQQIT--------------------- 1547
+ L+E+ + +L+ +RL+Q+L D T + RQ +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 1548 -----------EKEEKTRKAIVAAKS--------------------KIAHLAGVKDQLTK 1576
E EK KA+ A++ + L KD + K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 1577 ENEELKQRNGALDQQKDE---------------------LDVRITALKSQYEGRISRLER 1615
EL++ AL+QQ +E L+V + A+K+Q+
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF--------- 1576
Query: 1616 ELREHQERHLEQRDEPQEPSNK-VPEQQRQITLKTTPASGERGIASTS 1662
ER L+ RDE E + + +Q R++ + +R +A S
Sbjct: 1577 ------ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Score = 94.0 bits (232), Expect = 2e-18
Identities = 126/557 (22%), Positives = 239/557 (42%), Gaps = 69/557 (12%)
Query: 2 AAVLQQVLERTEL--NKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFE--- 56
A L Q LE L +KL K+ +N+L++ L D ++D R +E +Q+ F+
Sbjct: 1401 AEALSQRLEEKALAYDKLEKT-KNRLQQELDDLTVDLD--HQRQVASNLEKKQKKFDQLL 1457
Query: 57 -----IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQS 111
I R + ++R E RE ++ L L + L+ E +E E + A
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADME 1514
Query: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
+K+++ +L ++ L Q++E + ++ L ++L+ + K L++ + ++A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 172 S-DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDE-LLALGREKGNEILELKCNLENK 229
+ ++ R+++ E++K LL Q L EL+ + + LA+ +K EI
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI---------- 1624
Query: 230 KEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLK----EAKEQQASMEEKFHNELNAHIKL 285
++ LE Q+ + + + K + L ++K E +E +AS +E F + KL
Sbjct: 1625 --DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 286 SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQM--EKEML 343
+L EA+ +L + + + A + + D + K + EK L
Sbjct: 1683 KSL--------EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734
Query: 344 E-KIGRLEKELENAN---DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
E +I +LE+ELE +LL+ RK + + A ++ +A K +L
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL---- 1790
Query: 400 NAYVETQDQLLLEKLENKR--INKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK 457
E Q++ L KL+ + + +EAK L+ Q E+ + + A L +
Sbjct: 1791 ----ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 458 LEQAMKEI-----------QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLME 506
E+ +KEI + +E +KAN + L+R E + + R L E
Sbjct: 1847 TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
Query: 507 LEEARGNHVIRDEEVSS 523
L++A + EVS+
Sbjct: 1907 LDDATEANEGLSREVST 1923
Score = 85.1 bits (209), Expect = 7e-16
Identities = 88/400 (22%), Positives = 185/400 (46%), Gaps = 47/400 (11%)
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
KV+ + Q EEL K E + V +E++ ++E +L++M+ K ++L L
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKV-------KEKQTKVEGELEEMERKHQQL------L 886
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
+E N L+E+ LQAE +L E EE R L+ K+ +
Sbjct: 887 EEKNI-LAEQ---LQAETELFAE--------------------AEEMRARLAAKK---QE 919
Query: 1368 IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK 1427
++++ ++ E N L N + +Q+ +DL + E+E ++ L + + + K
Sbjct: 920 LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 1428 VKTITQVKKIGRRYKTQY-EELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486
+K + + + +++ +E K +D++ E S+Q + + ++ + + + ++
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546
E + K E + L+K + + E +LQ+Q +LQ+++ L+ L +EE+L+ +
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL---AKKEEELQGAL 1096
Query: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQY 1606
+++T A K + L +L ++ E K ++QK +L + ALK++
Sbjct: 1097 ARGDDETLHKNNALK-VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
Query: 1607 EGRI--SRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
E + + ++ELR +E+ + + + E K E Q Q
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Score = 65.5 bits (158), Expect = 6e-10
Identities = 84/399 (21%), Positives = 170/399 (42%), Gaps = 43/399 (10%)
Query: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
L+ L+ TE KL V + K A + ++ ++E+ K +Q E+E L
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMK--AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 65 QERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQ-FTRTKEELEAE 123
+++ + + ++L+ L Q++A + E+ I Q R + Q + + R EE A
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV-IKQLRKLQAQMKDYQRELEEARAS 1667
Query: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDEL------QASDVSVK 177
+ ++ ++ ++L+ L ++ +L E+L S + + + DEL AS S
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 178 YREKR--------LEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGNEILELK 223
EKR LE+E E S LN + T ++ LA R + +
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 224 CNLENKKEEV-SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME---------- 272
LE + +E+ ++L+E +K+ + +E + +L+E EQ+A
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 273 EKFHNELNAHI----KLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL 328
EK E+ + + ++ YK + + A+ +L R +EE + A + + +Q L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Query: 329 LEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKG 367
+ ++ + + +E + L+ L + ++ R G
Sbjct: 1908 DDATEANEGLSRE----VSTLKNRLRRGGPISFSSSRSG 1942
Score = 42.7 bits (99), Expect = 0.004
Identities = 40/168 (23%), Positives = 81/168 (48%), Gaps = 13/168 (7%)
Query: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHE---KFKVESEQQYFEIEKRLSHSQER 67
+ +L +L +V++K + ++ +++I L+ + E K + + + EK+L +
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127
+ +E R + ++EK N ++K L + +E E R A ++ +L+ E D
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA-------SRRKLQRELDDA 1910
Query: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD--ELQASD 173
NE LS+E+ L ++R + S++ G QL L+ L+ SD
Sbjct: 1911 TEANEGLSREVSTLKNRLRR-GGPISFSSSRSGRRQLHLEGASLELSD 1957
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 177 bits (448), Expect = 1e-43
Identities = 348/1653 (21%), Positives = 667/1653 (40%), Gaps = 241/1653 (14%)
Query: 243 LKTSNEHLQKH---VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS--NLYKSAADDSE 297
L+ N+ LQ+ VEDLL + + +++ A L ++L L
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 298 AKSNELTRAVEELHKLLK------EAGEANKA-----IQDHLLEVEQSKDQMEKEMLEKI 346
+S EL R ++E + + G+ +A +Q +L+ ++ ++E+++LE+
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198
Query: 347 GRLE----KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAY 402
G LE ++ E++ DL SA R L EE+ +A++A++ M +L A
Sbjct: 199 GELEQQRLRDTEHSQDLESALIR----LEEEQ-----QRSASLAQV--NAMLREQLDQA- 246
Query: 403 VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
+ +Q L E + +++ KE+E + +R+ E + S + L + +
Sbjct: 247 -GSANQALSEDI--RKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQV 303
Query: 463 KEIQRLQEDTDKANKQSSV-----LERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIR 517
+RL + ++ + L R +R ++ LS +R L E+R +
Sbjct: 304 VGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR-----LAESRAEAALE 358
Query: 518 DEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR----LLVALRELGETREREEQETTS 573
+ + A + E + ++ +++ + Q Q+ L + ELG +R E++
Sbjct: 359 KQALLQAQLE---EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLE 415
Query: 574 SKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQ---RDMYRILLS------QTTGV 624
++ L L LE LR Q ++ D Q RD+ + +LS Q +G
Sbjct: 416 KD--QVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 473
Query: 625 AIPLHASS-----LDDVSLASTPKRPSTSQTVST---PAPVPVIESTEAIEAKAALKQLQ 676
AS+ L S P+R S + S P+P ST A+ A K+
Sbjct: 474 ERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQL 533
Query: 677 EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYR 736
++ + + +A + L L++Q++D S+ + QL + + E +
Sbjct: 534 QVQDMRGRYEASQDL-----LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQ 588
Query: 737 REITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEV 796
RE+ L N+ L+ ++ L VA+ +AE L++E+E L+ ++
Sbjct: 589 REVQRLRSANELLS--------------REKSNLAHSLQVAQQQAEELRQEREKLQAAQE 634
Query: 797 RLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE 856
L +QR+ L EQ G R E E R Q+E+LE + S L K+L
Sbjct: 635 ELRRQRDRLEEEQED--------AVQDGARVRRELERSHR---QLEQLEGKRSVLAKEL- 682
Query: 857 NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVA 916
VE R L+R ATL++ + E
Sbjct: 683 --VEVREALSR----------------------------------ATLQRDMLQAEKAEV 706
Query: 917 SQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
+++ + G + +++ +++LR E + D +L ++ Q + + L L
Sbjct: 707 AEALTKAEAG----RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762
Query: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKR---RAIESMEQQL 1033
+EK + ++ E + E Q +LE+ +E E +Q L+ R +A E++EQQL
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822
Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
L+ S +Q ++ + ++ S +QARR+ Q Q + A + E HA
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882
Query: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECK---ASWEERERMLKDEVSKCVCRCE 1150
L AA+ + ++ L + E L E + A E R L+ E + E
Sbjct: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 1151 DLEKQNRLLHDQI-----------EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
L + L QI E ++ K+V + +E SL E+ + E E
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA-----QASLREQRAAHE---ED 994
Query: 1200 LRFIRREKEIA--ETRFEVAQVESLRYRQRVELLER------ELQELQDSLNAEREKVQV 1251
L+ ++REKE A E E AQ++S R++ ELL R EL E +L ER++ +
Sbjct: 995 LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054
Query: 1252 TAKTMAQHEELMKKTE--------------TMNVVMETNKMLREEKERLEQDLQQMQAKV 1297
A++ Q +K++E + +E + R+ + R EQD + A
Sbjct: 1055 LAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT 1114
Query: 1298 RKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQK--DPDTEEYR 1355
+L +EA A +++ LQ + + L + + L +Q + + + R
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR 1174
Query: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK 1415
+ L E + + Q+ E + E+ RS + ++ E+L + E+ +
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234
Query: 1416 DLDAKIIDIQEKVKTITQVK-KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
L D ++K+ + + + +G+ + EL+ +V + ++ +
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGK----EAGELRTGLQEVERSRLEAR----------R 1280
Query: 1475 EMQELKETLNQAETKSKSLESQVENLQKTL-----SEKET--EARNLQEQTVQLQSELSR 1527
E+QEL+ + ++++ L ++ LQ L +EKE+ E L+++ ++ ++ L
Sbjct: 1281 ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV 1340
Query: 1528 LRQDLQ--DRTTQEEQLRQQITEKE--EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQ 1583
+RQ+LQ R QE++ + E+ +A K ++ H G++ +L E +
Sbjct: 1341 MRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400
Query: 1584 ----------RNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
R L+ + ++V+ A ++Q G S L R L + R P
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
Query: 1634 PSNKVPEQ------QRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMA 1687
P+ P + TL+ +P S + P + ++ P V + +
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520
Query: 1688 GNKS-----TPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQS-EGPVEHVPV- 1740
+ T +++ + + T A + ES+EA +S +G + V
Sbjct: 1521 AQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAE 1580
Query: 1741 FGSTSGSVRSTSPNVQPSISQPILTVQQQTQAT 1773
SVR + + ++ Q + T+++ QAT
Sbjct: 1581 LALQEESVRRSERERRATLDQ-VATLERSLQAT 1612
Score = 174 bits (442), Expect = 7e-43
Identities = 336/1556 (21%), Positives = 629/1556 (40%), Gaps = 189/1556 (12%)
Query: 25 LEKFLADQQSEIDGLKGRHEKF--KVESEQQYFEIEKRLSHSQERLVNE--TRECQSLRL 80
L K L+D +SE L+ + ++ K + Q E +R + R NE +RE +L
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR-EVQRLRSANELLSREKSNLAH 610
Query: 81 ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
L+ Q + L ++ ++L+ AQ+ + R ++ LE E+ D ++ R+ +ELE
Sbjct: 611 SLQVAQQQAEELRQEREKLQAAQE-------ELRRQRDRLEEEQEDAVQDGARVRRELER 663
Query: 141 LTEDVKRLNEK-------LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQ 193
+++L K L E L+ D LQA V + E + L
Sbjct: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS 723
Query: 194 NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
T L E + D L +++ L +L K +++RL Q+ K++ + Q+
Sbjct: 724 MTKLRAEEASLQDSL--------SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQ 775
Query: 254 VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL 313
E T A+E+Q +EE + A L + A EA +L E +L
Sbjct: 776 AEQEAT---VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQL 832
Query: 314 LKEAGEANKAIQDHLLEVEQSKDQMEK--EMLEKIGR----LEKELENANDLLSATKRKG 367
++ + ++ + E+EQ++ + ++ E LE+ R L KE L A +R+G
Sbjct: 833 QEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREG 892
Query: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTEL--YNAYVETQDQLLLEKLENKRINKYLDE 425
LSEE A + + +L +L +E + Q LL L + + L
Sbjct: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL--LAKETLTGELAG 950
Query: 426 IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
+ +++ A E+A ++ KL QA +E Q + A+++ L+R
Sbjct: 951 LRQQIIA----------TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEED--LQRL 998
Query: 486 NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE 545
R E ++L + L +L+ R++E A + + E +S+ + + +
Sbjct: 999 QREKEAAWRELEAERAQLQSQLQ--------REQEELLARLEAEKEELSEEIAALQ---- 1046
Query: 546 LQQQNQRLLVALRELGETREREEQETT--SSKITELQLKLESALTELE-QLRKSRQHQMQ 602
Q++++ LL+A E + +E E T S K+ + L + E+E Q R ++ Q Q
Sbjct: 1047 -QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662
++ R L +Q A A+ +V R Q S
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAA----AAHAQEVRRLQEQARDLGKQRDSC--------L 1153
Query: 663 TEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFAS 722
EA E + L+ L++ + ++E E ++ E E + Q R + ++ L +
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ----RQEAGELRRSLGEGA 1209
Query: 723 KRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE 782
K E L+ + E R + L + +EQ + + + ++ +
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
Query: 783 NLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET-------KQ 835
+++ + + L +Q + L +E L LQ + ER+E E+ +Q
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329
Query: 836 RL---SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT----KRQLDTETNLHL 888
RL + +E + E+ ++KL+ + + T R L L + K+QLD L L
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389
Query: 889 NTKEL----------LKNAQKEIATLKQHLSNMEVQVASQSSQ--------RTGKG---- 926
+ L A+ L+ L+ +EVQ + +Q R G G
Sbjct: 1390 KLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRA 1449
Query: 927 -----QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTS-LEESLNKE- 979
+P D ++ + E +N L+ S + TS L+ E
Sbjct: 1450 PSPAPRPVPGSPARDAPAE--GSGEGLNS-PSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
Query: 980 -KQVTEEVRKNIEVRLKESAEFQTQ---LEKKLMEVEKEKQELQDDKR---RAIESMEQQ 1032
+ E + + +E E +TQ L ++L E+E E+ R +A+ E+
Sbjct: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566
Query: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAAD 1092
+ LS VQ E+ ALQ S S ++ RR +Q + E EL A
Sbjct: 1567 RRSVDGRLSGVQAEL--ALQEESVRRS--ERERRATLDQVATLERSLQATESEL---RAS 1619
Query: 1093 VEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL 1152
E + K +K+ ++ L+E +ES+ ++ E + R L+ E+ + D
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKL----ELQRRSLEGELQRSRLGLSDR 1675
Query: 1153 EKQNRLLHDQIEKLSDKVVAS-VKEG----VQGPLNVSLSEEGKSQEQILEILRFIRREK 1207
E Q + L D+++ L +V S VK G LN +L++ +S+ + + +R +
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
Query: 1208 EIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE 1267
+ + ++L ++ + E + Q LQ+ L+A R Q ++ Q L ++ +
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR---QALSEARKQSSSLGEQVQ 1792
Query: 1268 TMNVVMETNKMLREEKE----RLEQDLQQMQA-------KVRKLELDILPLQEANAELSE 1316
T+ + ++ R E E +L + L+Q Q V+KL+ + LQE L
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
Query: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
L+AEK+ +E R + + V+ ++ D E KL S ++ +L+ E G
Sbjct: 1853 ALAQLEAEKREVERSALRLE---KDRVALRRTLDKVEREKLRSHEDT-----VRLSAEKG 1904
Query: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436
RL + + L Q IQ L+ + + Q ++DA+ Q++++ +V++
Sbjct: 1905 RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ----QQQLELQQEVER 1960
Query: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKS 1492
+ +AQ ++ +E A+ Q +++ LK L Q +S +
Sbjct: 1961 L--------RSAQAQTERTLE--ARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 160 bits (406), Expect = 1e-38
Identities = 283/1543 (18%), Positives = 615/1543 (39%), Gaps = 219/1543 (14%)
Query: 250 LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNE---LTRA 306
L+K + D ++ + +EQ + +K + AH + +E S E L +
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHS 611
Query: 307 VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKI---GRLEKELENANDLLSAT 363
++ + +E + + +Q E+ + +D++E+E + + R+ +ELE ++ L
Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671
Query: 364 KRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL 423
+ K ++L++E + + A + +D L EK E
Sbjct: 672 EGKRSVLAKELVEVREALSRATLQ------------------RDMLQAEKAE-------- 705
Query: 424 DEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDT--DKANKQSSV 481
V E KA + R E E + + + L+ ++ ++ L E DK + V
Sbjct: 706 ---VAEALTKA---EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
Query: 482 LERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541
+ + + +Q + + + E+ R + ++EV+ + S V Q
Sbjct: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ---- 815
Query: 542 NIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
E L+QQ L R E+ ++ +L +L ELEQ R+ Q Q+
Sbjct: 816 --EALEQQLPTL------------RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
Query: 602 QLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIE 661
+ ++ R+++ L + G+A+ L A+ + +L+ R + + V
Sbjct: 862 EALERAAREKEA---LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918
Query: 662 STEAIEAKAALKQL--------------------QEIFENYKKEKAENEKIQNEQLEKLQ 701
+EA+ + Q+I +K + E + + ++ +
Sbjct: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978
Query: 702 EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQK--LTATTQKQEQI 759
E LR Q L + E +E R ++ S +R Q+ L ++E++
Sbjct: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038
Query: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
+ + +E L +AE ++++ L L E + E L+ + +L
Sbjct: 1039 SEEIAALQQERDEGLLLAE------SEKQQALSLKESEKTALSEKLMGTRH-------SL 1085
Query: 820 QTIQGILERSETETKQRLS---SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
TI +ER + + + R S + L E+ L+ + E R L Q D
Sbjct: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL 1145
Query: 877 KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936
+Q D+ L E L+ + + + L E+ A + + + +G+ +++ +
Sbjct: 1146 GKQRDS----CLREAEELRTQLRLLEDARDGLRR-ELLEAQRKLRESQEGREVQRQEAGE 1200
Query: 937 LVSQLRQTEEQVNDLK---ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
L L + ++ L+ E L+++ E + + E ++ + EE R +
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG-- 1258
Query: 994 LKESAEFQT---QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV--- 1047
KE+ E +T ++E+ +E +E QEL RR ++ ++ + + L + L+ +Q +
Sbjct: 1259 -KEAGELRTGLQEVERSRLEARRELQEL----RRQMKMLDSENTRLGRELAELQGRLALG 1313
Query: 1048 --------QEALQRASTALSNE---QQARRDCQEQAKIAVEAQNKYE-RELMLHAADVEA 1095
+E L L E + R++ Q + E + ++ RE L + EA
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373
Query: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
K+Q+ + LE +A L A+ E R + L+ E+++ + E Q
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAA-EGRAQGLEAELARVEVQRRAAEAQ 1432
Query: 1156 NRLLHDQIEK-------------------LSDKVVASVKEGVQGPLNVSLSEEGK----- 1191
L + + D EG+ P + S +
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 1192 -----------------SQEQILEILRFIRREKEIAETRF-----EVAQVESLR--YRQR 1227
+ + L+ LR +RE++ T+ ++A++E+ R R
Sbjct: 1493 PATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR 1552
Query: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE-----TMNVVMETNKMLREE 1282
L++ + E +++ + ++ +A EE ++++E T++ V + L+
Sbjct: 1553 ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQAT 1612
Query: 1283 KERL---EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKA-- 1337
+ L ++ + +M+A KLE D L+E ++ L+ +++ LE +++R +
Sbjct: 1613 ESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672
Query: 1338 RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN-QNLI 1396
++ +Q + ++ +++ EV +Q E + A++ S +L + + L
Sbjct: 1673 SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT 1732
Query: 1397 QSLKED---LNKVRTEKETIQKDLDAKIID---IQEKVKTITQVKKIGRRYKTQY-EELK 1449
++L + LN R + +QK L A D +QE++ Q R+ + E+++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 1450 AQQDKVMETSAQ---SSGDHQEQHVSVQEMQELK----ETLNQAETKSKSLESQVENLQK 1502
+ +V + Q + G Q+ +++ QE + T+ + + + + L+ ++ +LQ+
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
Query: 1503 TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQ-----QITEKEEKTRKAI 1557
L++ E E R ++ ++L+ + LR+ L + E+LR +++ ++ + + +
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDK--VEREKLRSHEDTVRLSAEKGRLDRTL 1910
Query: 1558 VAAKSKIAHLAGVKDQLTKENEELKQRNGALD------QQKDELDVRITALKSQYEGRIS 1611
A+ ++A QL + L+Q + QQ+ EL + L+S
Sbjct: 1911 TGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTER 1970
Query: 1612 RLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASG 1654
LE R H++R ++ ++ ++ R+ + +P SG
Sbjct: 1971 TLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSG 2013
Score = 36.2 bits (82), Expect = 0.39
Identities = 37/155 (23%), Positives = 65/155 (41%), Gaps = 20/155 (12%)
Query: 1513 NLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI---------VAAKSK 1563
+LQE+ LQ ELSR+ L + ++L + E+ +A+ +
Sbjct: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL 137
Query: 1564 IAHLAGVKDQLTKENEELKQRNGAL---DQQKDELDVRITALKSQYEGRISRLERELREH 1620
+ ++ QL +E +++ A Q++ +L R+ QY+ R S LE++L E
Sbjct: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
Query: 1621 QERHLEQRDEPQEPSNKV--------PEQQRQITL 1647
+QR E S + EQQR +L
Sbjct: 198 SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASL 232
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 175 bits (443), Expect = 5e-43
Identities = 256/1207 (21%), Positives = 504/1207 (41%), Gaps = 185/1207 (15%)
Query: 389 VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
VKP +++T +D+L +K EN K + + ++ +E L+ +
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 442 EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
E Y A++ L+ K LE+ + E++ RL+E+ D+ + L+ + ++M Q+ DL
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 956
Query: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
+Q+ E EEA + ++ + A I + I LV +L ++ + L +
Sbjct: 957 EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1008
Query: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
+L T E+E + +T+L+ K ES ++ELE K + Q ++ + R+ +
Sbjct: 1009 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1061
Query: 618 LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
G A H D + + K + A + ++ E + ALK+++E
Sbjct: 1062 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1115
Query: 678 IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
+ E+ E+A K + ++ E+L+ T+L +TQ + +KR +
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
+ + E S + Q++ QK Q + +T+ L A + + L+KE
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 788 KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
L L Q ++ + +++ + LQ+ ER+ E L+ ++ KL++E
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1288
Query: 848 ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
+ + L + L ++ L QL DT+ L ET LN L+ ++E +L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
+ L D+ + + E ++ L +L S ++
Sbjct: 1349 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 965 YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
+ + V +LEE +K+ +E+ +N+ + +E A +LEK +++E +L D+
Sbjct: 1383 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
+R+ + ++E++ + + L+ +N + + RA ++ + A+EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
+ + ER + A++E L ++K+ V K LE++ + E+Q+ E K EE E
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
+ LK + + + R E E++ R L Q+ E+ +
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
A+ K+ ++G L ++ L + K +E+ ++ LR ++ RE E A + +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
++ + LE +L +LQ+ L A ER + Q + EEL N + + + L
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
+LE++L++ Q + EA ++ K+ QAE+ E +R A+
Sbjct: 1736 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1783
Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
QQ + +E R L E E K + I L+A+IA+ L+
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1827
Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
E + + EK+ K L K ++E + + +K+ +YK Q E+ A+
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1878
Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
+++LK L +AE +S+ + + LQ+ L E + +
Sbjct: 1879 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 1521 LQSELSR 1527
L+S+L R
Sbjct: 1924 LKSKLRR 1930
Score = 174 bits (442), Expect = 7e-43
Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)
Query: 778 EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
+ + + L+K KE + +E L + Q+ S L E++ NLL LQ + +E E +
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 911
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
RL+++ ++LE + ++ +LE E ++ L + + Q+LD + QL+ E +
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
A+ +I L+ E+ V + + K + +E + DL + L + EE+ +L
Sbjct: 972 EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1025
Query: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
T ++++M++ LE L KE++ +E+ K ++ +L+ + A+ Q Q+
Sbjct: 1026 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1078
Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
+ M++ K+++ELQ D +R A E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
+Q +L + L +++ E+++ L STA E +A+R+ + K E +E ++
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
+ +A++ EQ+ + + +L++ Q E + L + K E +++
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
L+ +V + +C D E+ L+D++ KL ++V E V G LN + + K + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1311
Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
+ ++ +E+ ETR + L ++ LE E LQD L+ E E Q
Sbjct: 1312 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
+ + ++L T+ + E K ++E E L Q ++ A KLE L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
Q+ EL + L +++L+ K+ + +Q L +S + + + EKE
Sbjct: 1426 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
+ + EE K E+ R+N L + S K+D L K + ET +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
++ ++ +++++++ K R + + LK Q ++ ++ + + + + Q H
Sbjct: 1543 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
E+++ ++ A K LE +++L+ +Q +LQ+++ ++
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+L+D +++ E E+K AKS A L +++ L KQ + ++
Sbjct: 1660 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
+EL ++ K + E RI++LE EL E Q D ++ + + + +
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 1645 ITLKTTPA 1652
+ + + A
Sbjct: 1773 LATERSTA 1780
Score = 174 bits (440), Expect = 1e-42
Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)
Query: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
K+ Q+ EN KE + E+ LQEQ+ T+L ++ ++ +L A+K+ E L+
Sbjct: 865 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 921
Query: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
+ + + +R Q+L A +K Q + + + L A +KL + +V AE +K
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 786 K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
K E E+L + + +E L E+R +L NL ++ E +E +
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
RL + EK E+ LK+KLE + H +L Q+ + K QL + + L
Sbjct: 1042 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 891 KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
E+ + NA K+I L+ H+S+++ + S+ + R K + ++ ++L + + E+ +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1159
Query: 949 NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
+ + + ++ + +L+E + +E+R+ ++E E Q ++
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
++K KQ L+ + + + L + K+ + + +++ +Q + S+ ++AR +
Sbjct: 1220 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
++ + QN+ E ML+ A+ +A++ AK+ V+ ++S Q +E Q+ Q L
Sbjct: 1279 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1334
Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
EE L+D++ + + ++LE+ N L D +KL D AS E +
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1390
Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
EEGK + Q +E E ++E + + L++EL +L
Sbjct: 1391 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
L+ +R+ V K + ++L+ + + ++ +E++R E + ++ + K L
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1488
Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
+ EA EL + ML+AE + L ++DV +N H + + K + EE
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1544
Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
+ L E E + + +L + LK + R A N+ + L+ L++ TE
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
K+ ++ DL D+ I +E +K + +++ + ++ + E+
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
+A +D++ T+ ++ + + ++QE L E L
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
N + + + LE+++ L++ L E++ R +Q QL +EL+ R Q
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
+ +QL +Q E K + A KSK A +A +++Q+ +E E + +L
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
Q+ +L + L+ + E +++ +E E ++ Q +E +E S ++ +R+
Sbjct: 1845 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902
Query: 1645 I 1645
+
Sbjct: 1903 L 1903
Score = 172 bits (435), Expect = 5e-42
Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)
Query: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
Q TR +EE++A++ +L +T ER + L E ++ ++ +E N + +LQ + + +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 171 ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
A ++ V+ K+ E E E+LH L E + + +L A ++ ++L+L+ LE +
Sbjct: 906 AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 961
Query: 231 EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
EE +R + Q+ K + E K +ED + + + + + S E K E ++S+L
Sbjct: 962 EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1013
Query: 291 SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
+ A++ E K+ LT+ + ++ E LEV K++ ++ LEK+ R L
Sbjct: 1014 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1060
Query: 350 EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
E + + ++ ++ + + A L EEEL AA++ +A+ K+ EL
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 403 VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
+ Q+ L E+ + K ++ +E+EA LK + E+ + L K EQ +
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1176
Query: 463 KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
+++ L+ + R E QV+++ Q+ + EL E + + +
Sbjct: 1177 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1218
Query: 523 SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
A++ +N + L+++N L LR LG+ ++ E ++ +++ ELQ
Sbjct: 1219 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 581 LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
K E A EL Q++++ V +L++ G AI L + D S
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1312
Query: 638 LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
L+S + T + + E+ + + L+QL+E + + + E + E
Sbjct: 1313 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1359
Query: 698 EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
+ L+ ++ L Q + +L + E L++ + +++EI +L ++ ++ A K E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 758 QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
+ N + Q+L L NL+K++ + L E +S +R+ AE R
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 811 GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
+ +L + ++ LE E T + L +++E L HE+ K+ LE
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
++E+ T L+ +L T+ D + L +N + L ++++ L++
Sbjct: 1540 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 907 HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
L E ++ + QR K + D + + QLR+ + Q+ D
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 951 LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
+ L+ + ++ ++ A T+ E + + ++ ++ E A Q LEK+ +
Sbjct: 1657 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
E + LQD+KRR I +E++L E + + ++ + V++A Q+A LSNE
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1773
Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
R E A+ +E QNK E LH + K ++ + + LEE ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
+ S +++++ LK+ + + ED R + +Q ++ ++K A VK+
Sbjct: 1833 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1881
Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
L L E + ++I R ++RE + A E +V +L+ + R
Sbjct: 1882 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 155 bits (391), Expect = 6e-37
Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)
Query: 49 ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
E E Q E E ++ Q++ NE +E + +L + L QL+A TE E E +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
R A + + E+EA + ++L E + + + + L E+L+E + +LQ
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 164 LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
L+ V+ + + K+LE E ++ QN L+ E K + + LA EK
Sbjct: 971 LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 218 EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
+ +LK E+ KKEE SR LE+ L+ + + DL ++ E K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
Q A EE+ L + DD A+ N + + EL + + E D
Sbjct: 1084 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1128
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
++ ++++ E++ L+ ELE+ D +AT+++ E+E+ + T
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1187
Query: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
+ A++ + K + E +Q K LE + + + L +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 428 KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
+EVE K L+ Q +E + ++A A L+ K+ + E++ + ++A ++ L
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 484 RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
+D + Q++D + + L +LEE R + + DEE +S
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 523 SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
+ +I S S+ Q S +E L++ +R + L T++ EE+ K+ + +
Sbjct: 1368 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1423
Query: 582 KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
+L+ EL+ L +Q QLV ++ +++ + LL++ ++ + D+ A
Sbjct: 1424 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1476
Query: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
R ++ +S + EA+EAK +E+ K KAE E + + + + +
Sbjct: 1477 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1524
Query: 702 EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
+ V +L + TQ++ + E L+D ++ T+ + +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1566
Query: 762 TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
Q L+G E+ +++A + + E++ +L R + E+ L ++R Q L
Sbjct: 1567 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1614
Query: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
K++L ++ LE + K E ++Q R L Q+ D +R+L+
Sbjct: 1615 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1662
Query: 882 TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
K +K+ +L+ L M++Q +++R K KE++ + ++
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 942 RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
+ D K RL +A + LEE L +E+ E + + +++ +
Sbjct: 1721 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
+L + +K + A + +E+Q EL+ L ++ V+ + AL
Sbjct: 1771 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
E+Q ++ +E+ A +++ ++K +E++L D + + KEQ K + + L
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
+ ++AE + A+ + +R L +
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 150 bits (379), Expect = 1e-35
Identities = 237/1147 (20%), Positives = 481/1147 (41%), Gaps = 176/1147 (15%)
Query: 6 QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
QQ+L+ E + ++ + KL+ K L D+ +D + K + E++
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Query: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
++ L+ +E+ N T+ + +L +LK + +ELE + + S F
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 116 TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
+L+A+ K L + E L L L +++ + N LK+ EL+ + +LQ
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1125
Query: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
S + + E++K L + L TEL+ T T + L RE+ E+ LK L
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1183
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
+ EE E Q+ ++ +H Q VE+L +L++ K +A+++ EK + +L
Sbjct: 1184 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
+++ A + E K +L V+EL + GE +A
Sbjct: 1238 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1276
Query: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
E+ +K+ +L+ E+E+ +L+ + K AI +++A++S ++++
Sbjct: 1277 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1326
Query: 401 AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
ET+ +L L +LE +R N D++ +E+EAK + ++ +++L++
Sbjct: 1327 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1371
Query: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
+L + K++Q + LE +R + ++++L+QQ + + E N
Sbjct: 1372 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
+ ++ + D+ + +++S N+E+ Q++ +LL + + + R+R E E
Sbjct: 1425 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Query: 571 TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
+ L L LE AL E+L ++ + ++ +V +D ++ + S
Sbjct: 1478 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537
Query: 620 QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
+T + L+D A+ + Q + + E E K +QLQ
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1595
Query: 677 EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
Y+ E + K + +KL+ + DL Q + A K+ LQ ++
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
++RE+ ++ AT ++ E+ ++ DL E LA AE + EKE L
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1713
Query: 794 SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
E L + G+N L + K+RL ++I +LE E+ +
Sbjct: 1714 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1746
Query: 854 KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
+ + +E R Q +L TE + AQK + +Q L
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1795
Query: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
++ S+ + G + K + L +++ Q EEQV + +T +++Q + +
Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 974 ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
+ E+++ E+ ++ E K +A + QL+++L E E+E Q + ++R+ ++++L
Sbjct: 1856 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1907
Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
E ++ ++ EV ++ NE + + +E + E E AD
Sbjct: 1908 DEATESNEAMGREVNAL--KSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1965
Query: 1094 EALQAAK 1100
+A++
Sbjct: 1966 NGTKASE 1972
Score = 92.0 bits (227), Expect = 6e-18
Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
KV+ + Q EE+ K + + E + E + LEQ Q+ + L+ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
E AE E L A+K+ LEE + +AR + + + + RK ++++ + +
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 956
Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
+QL EE +L+ E + A + ++ I + + NK+ E++ +++ DL +
Sbjct: 957 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
+ +EK K +T++K ++++ EL+ + + ++ + + GD + H +
Sbjct: 1016 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
++Q ELK L N A K + LE + +LQ+ L +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
++Q L EL L+ +L+ D T +++LR Q++T +E+TR
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
+ A ++LT++ E+ K+ LD+ K L+ L K + E
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
+ +LE +++E Q + + E ++KV + Q ++ T + G +A
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
++ ++ T + T K+ + R S++ + + +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
+S++ +Q F ST ++ Q I LT Q + +A A+ ++
Sbjct: 1373 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1420
Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
+ +++ QEL +V++ Q V F + A ++ + +E + +
Sbjct: 1421 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1476
Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
EA ++ +T + L + L+ EE + E+E V S+D +G+ V +
Sbjct: 1477 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1529
Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
+ T ME+ + + L+ +L + + + + Q +G+ + + + EE
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 1954 DDDENDGEHEDYEEDEEDD 1972
+ + +YE + ED+
Sbjct: 1590 KRRQLQRQLHEYETELEDE 1608
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 175 bits (443), Expect = 5e-43
Identities = 256/1207 (21%), Positives = 504/1207 (41%), Gaps = 185/1207 (15%)
Query: 389 VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
VKP +++T +D+L +K EN K + + ++ +E L+ +
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 442 EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
E Y A++ L+ K LE+ + E++ RL+E+ D+ + L+ + ++M Q+ DL
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 963
Query: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
+Q+ E EEA + ++ + A I + I LV +L ++ + L +
Sbjct: 964 EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1015
Query: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
+L T E+E + +T+L+ K ES ++ELE K + Q ++ + R+ +
Sbjct: 1016 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068
Query: 618 LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
G A H D + + K + A + ++ E + ALK+++E
Sbjct: 1069 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1122
Query: 678 IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
+ E+ E+A K + ++ E+L+ T+L +TQ + +KR +
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
+ + E S + Q++ QK Q + +T+ L A + + L+KE
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 788 KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
L L Q ++ + +++ + LQ+ ER+ E L+ ++ KL++E
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1295
Query: 848 ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
+ + L + L ++ L QL DT+ L ET LN L+ ++E +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
+ L D+ + + E ++ L +L S ++
Sbjct: 1356 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 965 YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
+ + V +LEE +K+ +E+ +N+ + +E A +LEK +++E +L D+
Sbjct: 1390 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
+R+ + ++E++ + + L+ +N + + RA ++ + A+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
+ + ER + A++E L ++K+ V K LE++ + E+Q+ E K EE E
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
+ LK + + + R E E++ R L Q+ E+ +
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
A+ K+ ++G L ++ L + K +E+ ++ LR ++ RE E A + +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
++ + LE +L +LQ+ L A ER + Q + EEL N + + + L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
+LE++L++ Q + EA ++ K+ QAE+ E +R A+
Sbjct: 1743 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1790
Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
QQ + +E R L E E K + I L+A+IA+ L+
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1834
Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
E + + EK+ K L K ++E + + +K+ +YK Q E+ A+
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1885
Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
+++LK L +AE +S+ + + LQ+ L E + +
Sbjct: 1886 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 1521 LQSELSR 1527
L+S+L R
Sbjct: 1931 LKSKLRR 1937
Score = 174 bits (442), Expect = 7e-43
Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)
Query: 778 EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
+ + + L+K KE + +E L + Q+ S L E++ NLL LQ + +E E +
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 918
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
RL+++ ++LE + ++ +LE E ++ L + + Q+LD + QL+ E +
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
A+ +I L+ E+ V + + K + +E + DL + L + EE+ +L
Sbjct: 979 EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1032
Query: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
T ++++M++ LE L KE++ +E+ K ++ +L+ + A+ Q Q+
Sbjct: 1033 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085
Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
+ M++ K+++ELQ D +R A E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
+Q +L + L +++ E+++ L STA E +A+R+ + K E +E ++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
+ +A++ EQ+ + + +L++ Q E + L + K E +++
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
L+ +V + +C D E+ L+D++ KL ++V E V G LN + + K + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1318
Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
+ ++ +E+ ETR + L ++ LE E LQD L+ E E Q
Sbjct: 1319 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
+ + ++L T+ + E K ++E E L Q ++ A KLE L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
Q+ EL + L +++L+ K+ + +Q L +S + + + EKE
Sbjct: 1433 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
+ + EE K E+ R+N L + S K+D L K + ET +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
++ ++ +++++++ K R + + LK Q ++ ++ + + + + Q H
Sbjct: 1550 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
E+++ ++ A K LE +++L+ +Q +LQ+++ ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+L+D +++ E E+K AKS A L +++ L KQ + ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
+EL ++ K + E RI++LE EL E Q D ++ + + + +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 1645 ITLKTTPA 1652
+ + + A
Sbjct: 1780 LATERSTA 1787
Score = 174 bits (440), Expect = 1e-42
Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)
Query: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
K+ Q+ EN KE + E+ LQEQ+ T+L ++ ++ +L A+K+ E L+
Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 928
Query: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
+ + + +R Q+L A +K Q + + + L A +KL + +V AE +K
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 786 K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
K E E+L + + +E L E+R +L NL ++ E +E +
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
RL + EK E+ LK+KLE + H +L Q+ + K QL + + L
Sbjct: 1049 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 891 KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
E+ + NA K+I L+ H+S+++ + S+ + R K + ++ ++L + + E+ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1166
Query: 949 NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
+ + + ++ + +L+E + +E+R+ ++E E Q ++
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
++K KQ L+ + + + L + K+ + + +++ +Q + S+ ++AR +
Sbjct: 1227 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
++ + QN+ E ML+ A+ +A++ AK+ V+ ++S Q +E Q+ Q L
Sbjct: 1286 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1341
Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
EE L+D++ + + ++LE+ N L D +KL D AS E +
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1397
Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
EEGK + Q +E E ++E + + L++EL +L
Sbjct: 1398 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
L+ +R+ V K + ++L+ + + ++ +E++R E + ++ + K L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1495
Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
+ EA EL + ML+AE + L ++DV +N H + + K + EE
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1551
Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
+ L E E + + +L + LK + R A N+ + L+ L++ TE
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
K+ ++ DL D+ I +E +K + +++ + ++ + E+
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
+A +D++ T+ ++ + + ++QE L E L
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
N + + + LE+++ L++ L E++ R +Q QL +EL+ R Q
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
+ +QL +Q E K + A KSK A +A +++Q+ +E E + +L
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
Q+ +L + L+ + E +++ +E E ++ Q +E +E S ++ +R+
Sbjct: 1852 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 1645 I 1645
+
Sbjct: 1910 L 1910
Score = 172 bits (435), Expect = 5e-42
Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)
Query: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
Q TR +EE++A++ +L +T ER + L E ++ ++ +E N + +LQ + + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 171 ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
A ++ V+ K+ E E E+LH L E + + +L A ++ ++L+L+ LE +
Sbjct: 913 AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 968
Query: 231 EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
EE +R + Q+ K + E K +ED + + + + + S E K E ++S+L
Sbjct: 969 EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1020
Query: 291 SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
+ A++ E K+ LT+ + ++ E LEV K++ ++ LEK+ R L
Sbjct: 1021 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1067
Query: 350 EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
E + + ++ ++ + + A L EEEL AA++ +A+ K+ EL
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 403 VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
+ Q+ L E+ + K ++ +E+EA LK + E+ + L K EQ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1183
Query: 463 KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
+++ L+ + R E QV+++ Q+ + EL E + + +
Sbjct: 1184 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1225
Query: 523 SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
A++ +N + L+++N L LR LG+ ++ E ++ +++ ELQ
Sbjct: 1226 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 581 LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
K E A EL Q++++ V +L++ G AI L + D S
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1319
Query: 638 LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
L+S + T + + E+ + + L+QL+E + + + E + E
Sbjct: 1320 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1366
Query: 698 EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
+ L+ ++ L Q + +L + E L++ + +++EI +L ++ ++ A K E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 758 QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
+ N + Q+L L NL+K++ + L E +S +R+ AE R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 811 GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
+ +L + ++ LE E T + L +++E L HE+ K+ LE
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
++E+ T L+ +L T+ D + L +N + L ++++ L++
Sbjct: 1547 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 907 HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
L E ++ + QR K + D + + QLR+ + Q+ D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 951 LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
+ L+ + ++ ++ A T+ E + + ++ ++ E A Q LEK+ +
Sbjct: 1664 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
E + LQD+KRR I +E++L E + + ++ + V++A Q+A LSNE
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1780
Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
R E A+ +E QNK E LH + K ++ + + LEE ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
+ S +++++ LK+ + + ED R + +Q ++ ++K A VK+
Sbjct: 1840 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1888
Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
L L E + ++I R ++RE + A E +V +L+ + R
Sbjct: 1889 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 155 bits (391), Expect = 6e-37
Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)
Query: 49 ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
E E Q E E ++ Q++ NE +E + +L + L QL+A TE E E +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
R A + + E+EA + ++L E + + + + L E+L+E + +LQ
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 164 LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
L+ V+ + + K+LE E ++ QN L+ E K + + LA EK
Sbjct: 978 LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 218 EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
+ +LK E+ KKEE SR LE+ L+ + + DL ++ E K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
Q A EE+ L + DD A+ N + + EL + + E D
Sbjct: 1091 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1135
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
++ ++++ E++ L+ ELE+ D +AT+++ E+E+ + T
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1194
Query: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
+ A++ + K + E +Q K LE + + + L +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 428 KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
+EVE K L+ Q +E + ++A A L+ K+ + E++ + ++A ++ L
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 484 RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
+D + Q++D + + L +LEE R + + DEE +S
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 523 SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
+ +I S S+ Q S +E L++ +R + L T++ EE+ K+ + +
Sbjct: 1375 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1430
Query: 582 KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
+L+ EL+ L +Q QLV ++ +++ + LL++ ++ + D+ A
Sbjct: 1431 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1483
Query: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
R ++ +S + EA+EAK +E+ K KAE E + + + + +
Sbjct: 1484 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1531
Query: 702 EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
+ V +L + TQ++ + E L+D ++ T+ + +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1573
Query: 762 TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
Q L+G E+ +++A + + E++ +L R + E+ L ++R Q L
Sbjct: 1574 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1621
Query: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
K++L ++ LE + K E ++Q R L Q+ D +R+L+
Sbjct: 1622 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1669
Query: 882 TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
K +K+ +L+ L M++Q +++R K KE++ + ++
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 942 RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
+ D K RL +A + LEE L +E+ E + + +++ +
Sbjct: 1728 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
+L + +K + A + +E+Q EL+ L ++ V+ + AL
Sbjct: 1778 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
E+Q ++ +E+ A +++ ++K +E++L D + + KEQ K + + L
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
+ ++AE + A+ + +R L +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 150 bits (379), Expect = 1e-35
Identities = 237/1147 (20%), Positives = 481/1147 (41%), Gaps = 176/1147 (15%)
Query: 6 QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
QQ+L+ E + ++ + KL+ K L D+ +D + K + E++
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Query: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
++ L+ +E+ N T+ + +L +LK + +ELE + + S F
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 116 TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
+L+A+ K L + E L L L +++ + N LK+ EL+ + +LQ
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1132
Query: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
S + + E++K L + L TEL+ T T + L RE+ E+ LK L
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1190
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
+ EE E Q+ ++ +H Q VE+L +L++ K +A+++ EK + +L
Sbjct: 1191 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
+++ A + E K +L V+EL + GE +A
Sbjct: 1245 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1283
Query: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
E+ +K+ +L+ E+E+ +L+ + K AI +++A++S ++++
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1333
Query: 401 AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
ET+ +L L +LE +R N D++ +E+EAK + ++ +++L++
Sbjct: 1334 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1378
Query: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
+L + K++Q + LE +R + ++++L+QQ + + E N
Sbjct: 1379 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
+ ++ + D+ + +++S N+E+ Q++ +LL + + + R+R E E
Sbjct: 1432 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 571 TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
+ L L LE AL E+L ++ + ++ +V +D ++ + S
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Query: 620 QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
+T + L+D A+ + Q + + E E K +QLQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1602
Query: 677 EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
Y+ E + K + +KL+ + DL Q + A K+ LQ ++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
++RE+ ++ AT ++ E+ ++ DL E LA AE + EKE L
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1720
Query: 794 SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
E L + G+N L + K+RL ++I +LE E+ +
Sbjct: 1721 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1753
Query: 854 KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
+ + +E R Q +L TE + AQK + +Q L
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1802
Query: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
++ S+ + G + K + L +++ Q EEQV + +T +++Q + +
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 974 ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
+ E+++ E+ ++ E K +A + QL+++L E E+E Q + ++R+ ++++L
Sbjct: 1863 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1914
Query: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
E ++ ++ EV ++ NE + + +E + E E AD
Sbjct: 1915 DEATESNEAMGREVNAL--KSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1972
Query: 1094 EALQAAK 1100
+A++
Sbjct: 1973 NGTKASE 1979
Score = 92.0 bits (227), Expect = 6e-18
Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
KV+ + Q EE+ K + + E + E + LEQ Q+ + L+ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
E AE E L A+K+ LEE + +AR + + + + RK ++++ + +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 963
Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
+QL EE +L+ E + A + ++ I + + NK+ E++ +++ DL +
Sbjct: 964 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
+ +EK K +T++K ++++ EL+ + + ++ + + GD + H +
Sbjct: 1023 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
++Q ELK L N A K + LE + +LQ+ L +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
++Q L EL L+ +L+ D T +++LR Q++T +E+TR
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
+ A ++LT++ E+ K+ LD+ K L+ L K + E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
+ +LE +++E Q + + E ++KV + Q ++ T + G +A
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
++ ++ T + T K+ + R S++ + + +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
+S++ +Q F ST ++ Q I LT Q + +A A+ ++
Sbjct: 1380 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1427
Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
+ +++ QEL +V++ Q V F + A ++ + +E + +
Sbjct: 1428 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1483
Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
EA ++ +T + L + L+ EE + E+E V S+D +G+ V +
Sbjct: 1484 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1536
Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
+ T ME+ + + L+ +L + + + + Q +G+ + + + EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 1954 DDDENDGEHEDYEEDEEDD 1972
+ + +YE + ED+
Sbjct: 1597 KRRQLQRQLHEYETELEDE 1615
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 174 bits (442), Expect = 7e-43
Identities = 202/968 (20%), Positives = 418/968 (43%), Gaps = 135/968 (13%)
Query: 778 EVRAENLKKEKEMLKLSEVRLSQ--QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQ 835
+ + + L+K KE + +E L + Q+ S L E++ NLL LQ + +E E +
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEK--NLLQEQLQAETELYAEAE-EMRV 918
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLT---RNLDVQLLDTKRQLDTETNLHLNTKE 892
RL+++ ++LE + ++ +LE E ++ L + + Q+LD + QL+ E +
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLK 952
A+ +I L+ E+ V + + K + +E + DL + L + EE+ +L
Sbjct: 979 EKVTAEAKIKKLED-----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL- 1032
Query: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK--------ESAEFQTQL 1004
T ++++M++ LE L KE++ +E+ K ++ +L+ + A+ Q Q+
Sbjct: 1033 ------TKLKNKHESMISELEVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQI 1085
Query: 1005 EKKLMEVEKEKQELQ----------------------------------DDKRRAIESME 1030
+ M++ K+++ELQ D +R A E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--KIAVEAQNKYERELM- 1087
+Q +L + L +++ E+++ L STA E +A+R+ + K E +E ++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD--STATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 1088 LHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ----------LLECKASWEERERM 1137
+ +A++ EQ+ + + +L++ Q E + L + K E +++
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
L+ +V + +C D E+ L+D++ KL ++V E V G LN + + K + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVA 1318
Query: 1198 EILRFIRREKEI--AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ----- 1250
+ ++ +E+ ETR + L ++ LE E LQD L+ E E Q
Sbjct: 1319 SLSSQLQDTQELLQEETR------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 1251 ---VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
+ + ++L T+ + E K ++E E L Q ++ A KLE L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL-----VSQQKDPDTEEYRKLLSEKE 1362
Q+ EL + L +++L+ K+ + +Q L +S + + + EKE
Sbjct: 1433 QQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 1363 VHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED-------LNKVRTEKETIQK 1415
+ + EE K E+ R+N L + S K+D L K + ET +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ-----H 1470
++ ++ +++++++ K R + + LK Q ++ ++ + + + + Q H
Sbjct: 1550 EMKTQLEELEDELQATEDAK---LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQ 1530
E+++ ++ A K LE +++L+ +Q +LQ+++ ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 1531 DLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
+L+D +++ E E+K AKS A L +++ L KQ + ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKK-------AKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 1591 QKDELDVRITAL------KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
+EL ++ K + E RI++LE EL E Q D ++ + + + +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 1645 ITLKTTPA 1652
+ + + A
Sbjct: 1780 LATERSTA 1787
Score = 174 bits (440), Expect = 1e-42
Identities = 230/1081 (21%), Positives = 473/1081 (43%), Gaps = 150/1081 (13%)
Query: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQV---TDLRSQNTKISTQLDFASKRYEMLQ 729
K+ Q+ EN KE + E+ LQEQ+ T+L ++ ++ +L A+K+ E L+
Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL--AAKKQE-LE 928
Query: 730 DNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR---GANEKLAVAEVRAE-NLK 785
+ + + +R Q+L A +K Q + + + L A +KL + +V AE +K
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 786 K-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLT---------NLQTIQGILERSETETKQ 835
K E E+L + + +E L E+R +L NL ++ E +E +
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 836 RLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL-----DTETNLHLNT 890
RL + EK E+ LK+KLE + H +L Q+ + K QL + + L
Sbjct: 1049 RLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 891 KELLK--NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV 948
E+ + NA K+I L+ H+S+++ + S+ + R K + ++ ++L + + E+ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARN-KAEKQKRDLGEELEALKTELEDTL 1166
Query: 949 NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKL 1008
+ + + ++ + +L+E + +E+R+ ++E E Q ++
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 1009 MEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC 1068
++K KQ L+ + + + L + K+ + + +++ +Q + S+ ++AR +
Sbjct: 1227 ANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 1069 QEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
++ + QN+ E ML+ A+ +A++ AK+ V+ ++S Q +E Q+ Q L
Sbjct: 1286 NDKVH---KLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNV 1341
Query: 1128 KASW---EERERMLKDEVSKCVCRCEDLEKQ----NRLLHDQIEKLSDKVVASVKEGVQG 1180
EE L+D++ + + ++LE+ N L D +KL D AS E +
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD--FASTVEAL-- 1397
Query: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240
EEGK + Q +E E ++E + + L++EL +L
Sbjct: 1398 -------EEGKKRFQ---------KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1241 SLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL 1300
L+ +R+ V K + ++L+ + + ++ +E++R E + ++ + K L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNIS------SKYADERDRAEAEAREKETKALSL 1495
Query: 1301 ELDILPLQEANAELSEKSGMLQAEKKLL---EEDVKRWKARNQHLVSQQK---DPDTEEY 1354
+ EA EL + ML+AE + L ++DV +N H + + K + EE
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHELEKSKRALETQMEEM 1551
Query: 1355 RKLLSEKEVHTKRIQ----QLTEEIGRLKAEIARS-NASLTNNQNLIQSLKEDLNKVRTE 1409
+ L E E + + +L + LK + R A N+ + L+ L++ TE
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 1410 --------------KETIQKDL-------DAKIIDIQEKVKTITQVKKIGRRYKTQYEEL 1448
K+ ++ DL D+ I +E +K + +++ + ++ + E+
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQE------------------LKETL------- 1483
+A +D++ T+ ++ + + ++QE L E L
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 1484 NQAETKSKSLESQVENLQKTLSEKE-------TEARNLQEQTVQLQSELSRLRQDLQDRT 1536
N + + + LE+++ L++ L E++ R +Q QL +EL+ R Q
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKI--------AHLAGVKDQLTKENEELKQRNGAL 1588
+ +QL +Q E K + A KSK A +A +++Q+ +E E + +L
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 1589 DQQKDELDVRITALKSQYEGRISRLERELREHQERHLE----QRDEPQEPSNKVPEQQRQ 1644
Q+ +L + L+ + E +++ +E E ++ Q +E +E S ++ +R+
Sbjct: 1852 KQKDKKL--KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909
Query: 1645 I 1645
+
Sbjct: 1910 L 1910
Score = 173 bits (439), Expect = 2e-42
Identities = 255/1205 (21%), Positives = 503/1205 (41%), Gaps = 185/1205 (15%)
Query: 389 VKPGMKLTELYNAYVETQDQLLL-----EKLEN--KRINKYLDEIVKEVEAKAPILKRQR 441
VKP +++T +D+L +K EN K + + ++ +E L+ +
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 442 EEYERAQKAVASLSVK---LEQAMKEIQ-RLQEDTDKANKQSSVLERDNRRMEIQVKDLS 497
E Y A++ L+ K LE+ + E++ RL+E+ D+ + L+ + ++M Q+ DL
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ----LQAERKKMAQQMLDLE 963
Query: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
+Q+ E EEA + ++ + A I + I LV +L ++ + L +
Sbjct: 964 EQL-----EEEEAARQKLQLEKVTAEAKIKKLEDEI---LVMDDQNNKLSKERKLLEERI 1015
Query: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
+L T E+E + +T+L+ K ES ++ELE K + Q ++ + R+ +
Sbjct: 1016 SDL--TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068
Query: 618 LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
G A H D + + K + A + ++ E + ALK+++E
Sbjct: 1069 -----GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD-EIAQKNNALKKIRE 1122
Query: 678 IF-------ENYKKEKAENEKIQNEQL---EKLQEQVTDLRSQNTKISTQLDFASKRYEM 727
+ E+ E+A K + ++ E+L+ T+L +TQ + +KR +
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 728 LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
+ + E S + Q++ QK Q + +T+ L A + + L+KE
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMR---QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 788 KEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847
L L Q ++ + +++ + LQ+ ER+ E L+ ++ KL++E
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNE 1295
Query: 848 ISHLKKKLENEVEQRHTLTRN---LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
+ + L + L ++ L QL DT+ L ET LN L+ ++E +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
+ L D+ + + E ++ L +L S ++
Sbjct: 1356 QDQL--------------------------DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 965 YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ---DD 1021
+ + V +LEE +K+ +E+ +N+ + +E A +LEK +++E +L D+
Sbjct: 1390 FASTVEALEEG---KKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 1022 KRRAIESMEQQLSELKKTLSSVQN---EVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
+R+ + ++E++ + + L+ +N + + RA ++ + A+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERE--- 1135
+ + ER + A++E L ++K+ V K LE++ + E+Q+ E K EE E
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 1136 --------------RMLKDEVSKCV-CRCEDLEKQNRLLHDQI---------EKLSDKVV 1171
+ LK + + + R E E++ R L Q+ E+ +
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 1172 ASVKEGVQGPL-NVSLSEEG--KSQEQILEILRFIR-------REKEIAETRFEVAQVES 1221
A+ K+ ++G L ++ L + K +E+ ++ LR ++ RE E A + +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 1222 LRYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLR 1280
++ + LE +L +LQ+ L A ER + Q + EEL N + + + L
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 1281 EEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ 1340
+LE++L++ Q + EA ++ K+ QAE+ E +R A+
Sbjct: 1743 ARIAQLEEELEEEQGNM-----------EAMSDRVRKATQ-QAEQLSNELATERSTAQKN 1790
Query: 1341 HLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK 1400
QQ + +E R L E E K + I L+A+IA+ L+
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQ--------------LE 1834
Query: 1401 EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA 1460
E + + EK+ K L K ++E + + +K+ +YK Q E+ A+
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR--------- 1885
Query: 1461 QSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQ 1520
+++LK L +AE +S+ + + LQ+ L E + +
Sbjct: 1886 ---------------VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 1521 LQSEL 1525
L+S+L
Sbjct: 1931 LKSKL 1935
Score = 172 bits (435), Expect = 5e-42
Identities = 261/1190 (21%), Positives = 521/1190 (43%), Gaps = 180/1190 (15%)
Query: 112 QFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD-ELQ 170
Q TR +EE++A++ +L +T ER + L E ++ ++ +E N + +LQ + + +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 171 ASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKK 230
A ++ V+ K+ E E E+LH L E + + +L A ++ ++L+L+ LE +
Sbjct: 913 AEEMRVRLAAKKQELE-EILHEMEARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLE--E 968
Query: 231 EEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYK 290
EE +R + Q+ K + E K +ED + + + + + S E K E ++S+L
Sbjct: 969 EEAARQKLQLE--KVTAEAKIKKLEDEILVMDD-QNNKLSKERKLLEE-----RISDLTT 1020
Query: 291 SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR-L 349
+ A++ E K+ LT+ + ++ E LEV K++ ++ LEK+ R L
Sbjct: 1021 NLAEEEE-KAKNLTKLKNKHESMISE------------LEVRLKKEEKSRQELEKLKRKL 1067
Query: 350 EKELENANDLLSATKRKGAIL------SEEEL-AAMSPTAAAVAKIVKPGMKLTELYNAY 402
E + + ++ ++ + + A L EEEL AA++ +A+ K+ EL
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 403 VETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAM 462
+ Q+ L E+ + K ++ +E+EA LK + E+ + L K EQ +
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEA----LKTELEDTLDSTATQQELRAKREQEV 1183
Query: 463 KEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
+++ L+ + R E QV+++ Q+ + EL E + + +
Sbjct: 1184 TVLKK-------------ALDEETRSHEAQVQEMRQKHAQAVEELTEQ-----LEQFKRA 1225
Query: 523 SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREE--QETTSSKITELQ 580
A++ +N + L+++N L LR LG+ ++ E ++ +++ ELQ
Sbjct: 1226 KANLD-------------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 581 LKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
K E A EL Q++++ V +L++ G AI L + D S
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL---AKDVAS 1319
Query: 638 LASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQL 697
L+S + T + + E+ + + L+QL+E + + + E + E
Sbjct: 1320 LSS--QLQDTQELLQE-------ETRQKLNVSTKLRQLEEERNSLQDQLDE----EMEAK 1366
Query: 698 EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQE 757
+ L+ ++ L Q + +L + E L++ + +++EI +L ++ ++ A K E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 758 QIINTMTQDLRGANEKLAVAEVRAENLKKEK---EMLKLSEVRLS----QQRESLLAEQR 810
+ N + Q+L L NL+K++ + L E +S +R+ AE R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 811 GQNLLLTNL-QTIQGILERSE--TETKQRLSSQIEKL----------EHEISHLKKKLEN 857
+ +L + ++ LE E T + L +++E L HE+ K+ LE
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT-----------LKQ 906
++E+ T L+ +L T+ D + L +N + L ++++ L++
Sbjct: 1547 QMEEMKTQLEELEDELQATE---DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 907 HLSNMEVQVASQSSQRTGKGQPSNKEDVD----------------DLVSQLRQTEEQVND 950
L E ++ + QR K + D + + QLR+ + Q+ D
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 951 LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
+ L+ + ++ ++ A T+ E + + ++ ++ E A Q LEK+ +
Sbjct: 1664 FQRELEDARASRDEIFA--TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 1011 VE-----KEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
E + LQD+KRR I +E++L E + + ++ + V++A Q+A LSNE
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE-QLSNEL 1780
Query: 1063 QARRDC---QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK 1119
R E A+ +E QNK E LH + K ++ + + LEE ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
+ S +++++ LK+ + + ED R + +Q ++ ++K A VK+
Sbjct: 1840 EAREKQAATKSLKQKDKKLKE----ILLQVED----ERKMAEQYKEQAEKGNARVKQ--- 1888
Query: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV--AQVESLRYRQR 1227
L L E + ++I R ++RE + A E +V +L+ + R
Sbjct: 1889 --LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 161 bits (408), Expect = 6e-39
Identities = 234/1174 (19%), Positives = 493/1174 (41%), Gaps = 174/1174 (14%)
Query: 229 KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNL 288
++EE+ E+++ K + + +++L K + E++ ++E+ E + + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
A AK EL + E+ L+E +D +++ + +M ++ML+
Sbjct: 917 RVRLA----AKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLD---- 961
Query: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
LE++LE + ++L TA A K ++ + + + N + + +
Sbjct: 962 LEEQLEEEE------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 409 LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468
LL E++ + N + E E KA L + + ++E S+ +LE +K+ ++
Sbjct: 1010 LLEERISDLTTN------LAEEEEKAKNLTKLKNKHE-------SMISELEVRLKKEEKS 1056
Query: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
+++ +K ++ LE D Q+ DL QI L M+L + ++EE+ +A ++
Sbjct: 1057 RQELEKLKRK---LEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAA-LAR 1105
Query: 529 SSEVISQHLVSYRNIEELQ------QQNQRLLVALRELGETREREEQETTSSKITELQLK 582
+ I+Q + + I EL+ Q++ A R E ++R+ E + TEL+
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 583 LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTP 642
L+S T+ ++LR R+ ++ ++ +LD+ T
Sbjct: 1166 LDSTATQ-QELRAKREQEVTVLKK-------------------------ALDE----ETR 1195
Query: 643 KRPSTSQTVSTPAPVPVIESTEAIE----AKAALKQLQEIFENYKKEKAENEKIQNEQLE 698
+ Q + V E TE +E AKA L + ++ E + A ++ + +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 699 KLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQ 758
+++ + L +Q ++ ++ + L D V + E+ S+ + K +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 759 IINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTN 818
+ +++ L+ E L E + L ++ +L E R S Q + L E + L +
Sbjct: 1316 DVASLSSQLQDTQELLQ--EETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQNLERH 1372
Query: 819 LQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
+ T+ ++ S+++ K Q +S +E LE +K++EN +Q D +L TK
Sbjct: 1373 ISTLN--IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLEKTK 1429
Query: 878 RQLDTETNLHL----NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
+L E + + N ++L+ N +K+ Q L+ E ++S+ + + + +E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREK 1488
Query: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
+S R EE + + KE L+ + ++ + S ++ + K E+ ++ +E +
Sbjct: 1489 ETKALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
++E +LE +L E K L+ + + E+ L + + ++Q L
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 1054 ASTALSNEQQAR--------------RDCQEQAKIAVEAQNK--------------YERE 1085
T L +E++ R +D + QA A++ + + ++RE
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 1086 LM-LHAADVEALQAAKEQVSKMASVR---QHLEETTQKAE----------SQLLECKASW 1131
L A+ E AKE K S+ L+E AE +L E AS
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 1132 EERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV----SLS 1187
L+DE + R LE++ +E +SD+V + ++ Q + S +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
++ +S Q LE R+ KE+ E+ +++ + LE ++ +L++ + E
Sbjct: 1788 QKNESARQQLE-----RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKM-----------------LREEKERLEQDL 1290
+ Q K++ Q ++ +K E + V + KM L+ + E E++
Sbjct: 1843 EKQAATKSLKQKDKKLK--EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 1291 QQMQAKVRKLELDILPLQEANAELSEKSGMLQAE 1324
Q++ A RKL+ ++ E+N + + L+++
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 155 bits (391), Expect = 6e-37
Identities = 242/1167 (20%), Positives = 486/1167 (41%), Gaps = 183/1167 (15%)
Query: 49 ESEQQYFEIE-KRLSHSQERLVNETRECQSLRLELEK----LNNQLKALTEKNKELEIAQ 103
E E Q E E ++ Q++ NE +E + +L + L QL+A TE E E +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
R A + + E+EA + ++L E + + + + L E+L+E + +LQ
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 164 LKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDEL------LALGREKGN 217
L+ V+ + + K+LE E ++ QN L+ E K + + LA EK
Sbjct: 978 LE-------KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 218 EILELKCNLEN---------KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
+ +LK E+ KKEE SR LE+ L+ + + DL ++ E K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
Q A EE+ L + DD A+ N + + EL + + E D
Sbjct: 1091 QLAKKEEELQAAL-----------ARLDDEIAQKNNALKKIRELEGHISDLQED----LD 1135
Query: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAM-----SPT 381
++ ++++ E++ L+ ELE+ D +AT+++ E+E+ + T
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEET 1194
Query: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEK---------LENKRIN-----KYLDEIV 427
+ A++ + K + E +Q K LE + + + L +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 428 KEVEAKAPILKRQREEYER----AQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLE 483
+EVE K L+ Q +E + ++A A L+ K+ + E++ + ++A ++ L
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 484 RDNRRMEIQVKDLSQ----------QIRVLLMELEEARGNHVIR-DEE----------VS 522
+D + Q++D + + L +LEE R + + DEE +S
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 523 SADIS-SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL 581
+ +I S S+ Q S +E L++ +R + L T++ EE+ K+ + +
Sbjct: 1375 TLNIQLSDSKKKLQDFAS--TVEALEEGKKRFQKEIENL--TQQYEEKAAAYDKLEKTKN 1430
Query: 582 KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641
+L+ EL+ L +Q QLV ++ +++ + LL++ ++ + D+ A
Sbjct: 1431 RLQQ---ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS----SKYADERDRAEA 1483
Query: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQ 701
R ++ +S + EA+EAK +E+ K KAE E + + + + +
Sbjct: 1484 EAREKETKALSLARAL-----EEALEAK------EELERTNKMLKAEMEDLVSSK-DDVG 1531
Query: 702 EQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIIN 761
+ V +L + TQ++ + E L+D ++ T+ + +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQ------------------ATEDAKLRLE 1573
Query: 762 TMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
Q L+G E+ +++A + + E++ +L R + E+ L ++R Q L
Sbjct: 1574 VNMQALKGQFER----DLQARDEQNEEKRRQLQ--RQLHEYETELEDERKQRAL------ 1621
Query: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
K++L ++ LE + K E ++Q R L Q+ D +R+L+
Sbjct: 1622 --------AAAAKKKLEGDLKDLELQADSAIKGREEAIKQ----LRKLQAQMKDFQRELE 1669
Query: 882 TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
K +K+ +L+ L M++Q +++R K KE++ + ++
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADL--MQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 942 RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
+ D K RL +A + LEE L +E+ E + + +++ +
Sbjct: 1728 LSGRNALQDEKRRL----------EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSN- 1060
+L + +K + A + +E+Q EL+ L ++ V+ + AL
Sbjct: 1778 NELATERSTAQKNES--------ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 1061 ----EQQARRDCQEQ--AKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHL 1113
E+Q ++ +E+ A +++ ++K +E++L D + + KEQ K + + L
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 1114 EETTQKAESQLLECKASWEERERMLKD 1140
+ ++AE + A+ + +R L +
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 149 bits (377), Expect = 2e-35
Identities = 229/1094 (20%), Positives = 464/1094 (42%), Gaps = 174/1094 (15%)
Query: 6 QQVLERTELNKLPKSVQNKLE----------KFLADQQSEIDGLKGRHEKFKVESEQQYF 55
QQ+L+ E + ++ + KL+ K L D+ +D + K + E++
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Query: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
++ L+ +E+ N T+ + +L +LK + +ELE + + S F
Sbjct: 1017 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 116 TKEELEAE----KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQA 171
+L+A+ K L + E L L L +++ + N LK+ EL+ + +LQ
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQE 1132
Query: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELK-----TKTDELLALGREKGNEILELKCNL 226
S + + E++K L + L TEL+ T T + L RE+ E+ LK L
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ--EVTVLKKAL 1190
Query: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME------EKFHNELN 280
+ EE E Q+ ++ +H Q VE+L +L++ K +A+++ EK + +L
Sbjct: 1191 D---EETRSHEAQVQEMR--QKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
+++ A + E K +L V+EL + GE +A
Sbjct: 1245 GELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSD-GERARA----------------- 1283
Query: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
E+ +K+ +L+ E+E+ +L+ + K AI +++A++S ++++
Sbjct: 1284 ELNDKVHKLQNEVESVTGMLNEAEGK-AIKLAKDVASLSSQLQDTQELLQE--------- 1333
Query: 401 AYVETQDQL----LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
ET+ +L L +LE +R N D++ +E+EAK + ++ +++L++
Sbjct: 1334 ---ETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAK-----------QNLERHISTLNI 1378
Query: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI--RVLLMELEEARGNH 514
+L + K++Q + LE +R + ++++L+QQ + + E N
Sbjct: 1379 QLSDSKKKLQDFASTVE-------ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALREL----GETREREEQE 570
+ ++ + D+ + +++S N+E+ Q++ +LL + + + R+R E E
Sbjct: 1432 LQQELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Query: 571 TTSSKITELQL--KLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS---- 619
+ L L LE AL E+L ++ + ++ +V +D ++ + S
Sbjct: 1485 AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544
Query: 620 QTTGVAIPLHASSLDDVSLASTPKR---PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
+T + L+D A+ + Q + + E E K +QLQ
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR--RQLQ 1602
Query: 677 EIFENYKKEKAENEK---IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVE 733
Y+ E + K + +KL+ + DL Q + A K+ LQ ++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKL 793
++RE+ ++ AT ++ E+ ++ DL E LA AE + EKE L
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL-- 1720
Query: 794 SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK 853
E L + G+N L + K+RL ++I +LE E+ +
Sbjct: 1721 --------AEELASSLSGRNAL---------------QDEKRRLEARIAQLEEEL----E 1753
Query: 854 KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
+ + +E R Q +L TE + AQK + +Q L
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERS----------TAQKN-ESARQQLERQNK 1802
Query: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
++ S+ + G + K + L +++ Q EEQV + +T +++Q + +
Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 974 ESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
+ E+++ E+ ++ E K +A + QL+++L E E+E Q + ++R+ ++++L
Sbjct: 1863 LQVEDERKMAEQYKEQAE---KGNARVK-QLKRQLEEAEEESQRINANRRK----LQREL 1914
Query: 1034 SELKKTLSSVQNEV 1047
E ++ ++ EV
Sbjct: 1915 DEATESNEAMGREV 1928
Score = 107 bits (268), Expect = 1e-22
Identities = 197/942 (20%), Positives = 374/942 (39%), Gaps = 176/942 (18%)
Query: 19 KSVQNKLEKFLADQQSEIDGLK----------GRHEKFKVESEQQYFEIEKRL---SHSQ 65
++ +NK EK D E++ LK ++ + + EQ+ ++K L + S
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 66 ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR 125
E V E R Q +E+L QL E+ K + D+N K+ LE E
Sbjct: 1198 EAQVQEMR--QKHAQAVEELTEQL----EQFKRAKANLDKN----------KQTLEKENA 1241
Query: 126 DL---IRTNERLSQELEY----LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
DL +R + QE+E+ L V+ L K + + EL K+ +LQ SV
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEE 238
E + L L+++L+ T ELL +E+ + L + L +EE + L++
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQ-DTQELL---QEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 239 QMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298
Q++ + ++L++H+ L +L ++K+ KL + + S + E
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKK-----------------KLQD-FASTVEALEE 1399
Query: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND 358
+ +E L + +E A ++E++K+++++E+ + + L+ + + ++
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYD-------KLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 359 LLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKR 418
L ++ +L+EE+ + + Y + +D+ E
Sbjct: 1453 LEKKQRKFDQLLAEEK----------------------NISSKYADERDRAEAE------ 1484
Query: 419 INKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ 478
+E E KA L R EE A++ + + L+ M++ L D K
Sbjct: 1485 --------AREKETKALSLARALEEALEAKEELERTNKMLKAEMED---LVSSKDDVGKN 1533
Query: 479 SSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLV 538
LE+ R +E Q++++ Q LEE + DE ++ D EV
Sbjct: 1534 VHELEKSKRALETQMEEMKTQ-------LEE------LEDELQATEDAKLRLEV------ 1574
Query: 539 SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQ 598
N++ L+ Q +R L A E E + R +LQ +L TELE RK R
Sbjct: 1575 ---NMQALKGQFERDLQARDEQNEEKRR-----------QLQRQLHEYETELEDERKQRA 1620
Query: 599 HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA--------SSLDDVSLASTPKRPSTSQT 650
+ + D+ + L + + A + + D R S +
Sbjct: 1621 LAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 651 VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD---L 707
+T +A +A L QLQE ++ + + + + E E+L ++ L
Sbjct: 1679 FATAKE----NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 708 RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT---ATTQKQEQIINTMT 764
+ + ++ ++ + E Q N+E + ++ ++L+ AT + Q +
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 765 QDLRGANEKL--AVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL--- 819
Q L N++L + E+ K K + E +++Q E + E R + +L
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 820 -QTIQGILERSETETK--QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDT 876
+ ++ IL + E E K ++ Q EK + LK++LE E+ + N
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------- 1906
Query: 877 KRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918
+R+L E + + E + +E+ LK L Q SQ
Sbjct: 1907 RRKLQRELDEATESNEAM---GREVNALKSKLRGPPPQETSQ 1945
Score = 92.0 bits (227), Expect = 6e-18
Identities = 154/799 (19%), Positives = 325/799 (40%), Gaps = 104/799 (13%)
Query: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
KV+ + Q EE+ K + + E + E + LEQ Q+ + L+ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
E AE E L A+K+ LEE + +AR + + + + RK ++++ + +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE--EEDRGQQLQAERKKMAQQMLDLE- 963
Query: 1368 IQQLTEEIG---RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK---DLDAKI 1421
+QL EE +L+ E + A + ++ I + + NK+ E++ +++ DL +
Sbjct: 964 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1422 IDIQEKVKTITQVKKIGRRYKTQYEELKAQ-------QDKVMETSAQSSGDHQEQHVSVQ 1474
+ +EK K +T++K ++++ EL+ + + ++ + + GD + H +
Sbjct: 1023 AEEEEKAKNLTKLK---NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 1475 EMQ----ELKETL---------------------NQAETKSKSLESQVENLQKTLSEKET 1509
++Q ELK L N A K + LE + +LQ+ L +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1510 EARNLQEQTVQLQSELSRLRQDLQ---DRTTQEEQLR----QQIT----EKEEKTRKAIV 1558
++Q L EL L+ +L+ D T +++LR Q++T +E+TR
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL----------KSQYEG 1608
+ A ++LT++ E+ K+ LD+ K L+ L K + E
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG----IASTSDP 1664
+ +LE +++E Q + + E ++KV + Q ++ T + G +A
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1665 PTANIKPTPVV---STPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTT 1721
++ ++ T + T K+ + R S++ + + +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1722 QVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQTQATAFVQPTQQ 1781
+S++ +Q F ST ++ Q I LT Q + +A A+ ++
Sbjct: 1380 LSDSKKKLQD---------FASTVEALEEGKKRFQKEIEN--LTQQYEEKAAAY-DKLEK 1427
Query: 1782 SHPQIEPANQELSSNIVEV-VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTI 1840
+ +++ QEL +V++ Q V F + A ++ + +E + +
Sbjct: 1428 TKNRLQ---QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEA 1483
Query: 1841 EASDQVSDDTVEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ 1900
EA ++ +T + L + L+ EE + E+E V S+D +G+ V +
Sbjct: 1484 EAREK---ETKALSLARALEEALE-AKEELERTNKMLKAEMEDLV---SSKDDVGKNVHE 1536
Query: 1901 GD------YTPMEDSEETSQSLQIDLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE 1953
+ T ME+ + + L+ +L + + + + Q +G+ + + + EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 1954 DDDENDGEHEDYEEDEEDD 1972
+ + +YE + ED+
Sbjct: 1597 KRRQLQRQLHEYETELEDE 1615
Score = 90.1 bits (222), Expect = 2e-17
Identities = 114/525 (21%), Positives = 227/525 (43%), Gaps = 48/525 (9%)
Query: 13 ELNKLPKSVQNKLEKFLAD---QQSEIDGLKGRHEKF-KVESEQQYFEIEKRLSHSQERL 68
+L K +Q +L+ + D Q+ + L+ + KF ++ +E++ I + + ++R
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRA 1481
Query: 69 VNETRECQSLRLELEK-LNNQLKA---LTEKNKELEIAQDRNIAIQSQFTRTKEELEAEK 124
E RE ++ L L + L L+A L NK L+ + ++ + + ELE K
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 125 RDLIRTNERLSQELEYLTEDVKRLNE-KLK---ESNTTKGELQLKLDELQASDVSVKYRE 180
R L E + +LE L ++++ + KL+ KG+ + +LQA D + +
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER---DLQARDEQNEEKR 1598
Query: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN-EILELKCNLENKKEE-----VS 234
++L+++ LH T L E K + A + +G+ + LEL+ + K E +
Sbjct: 1599 RQLQRQ---LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 235 RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
+L+ QM + E + +++ KE +++ S+E +L + + + AD
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM-QLQEDLAAAERARKQAD 1714
Query: 295 -DSEAKSNELTRA-----------------VEELHKLLKEAGEANKAIQDHLLEVEQSKD 336
+ E + EL + + +L + L+E +A+ D + + Q +
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 337 QMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
Q+ E+ + +K L K + L E E A S + +A + +L
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 397 ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
E + Q + L+ K +K L EI+ +VE + + ++ +E+ E+ V L
Sbjct: 1835 EQVEQEAR-EKQAATKSLKQK--DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIR 501
+LE+A +E QR+ + K ++ N M +V L ++R
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,939,515
Number of Sequences: 37866
Number of extensions: 4250506
Number of successful extensions: 91455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1218
Number of HSP's successfully gapped in prelim test: 2217
Number of HSP's that attempted gapping in prelim test: 24146
Number of HSP's gapped (non-prelim): 29717
length of query: 2363
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2244
effective length of database: 13,741,464
effective search space: 30835845216
effective search space used: 30835845216
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.