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Search of human proteins with 22003858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22003858 ventricular zone expressed PH domain homolog 1
[Homo sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22003858 ventricular zone expressed PH domain homolog 1 [Homo... 1652 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 44 5e-04
gi|187608516 centaurin, beta 2 [Homo sapiens] 42 0.002
gi|50234893 pleckstrin homology domain containing, family A (pho... 40 0.012
gi|31377720 pleckstrin homology domain containing, family A (pho... 40 0.012
gi|7661880 centaurin beta1 [Homo sapiens] 39 0.020
gi|20149626 pleckstrin homology domain containing, family O memb... 39 0.026
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 38 0.034
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 38 0.034
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 38 0.034
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 38 0.044
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 38 0.044
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 38 0.044
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 38 0.044
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 38 0.044
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 37 0.099
gi|134142826 pericentriolar material 1 [Homo sapiens] 36 0.13
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 35 0.22
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 35 0.22
gi|4503917 growth arrest-specific 8 [Homo sapiens] 35 0.38
gi|192807323 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|192807320 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|192807318 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|192807316 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|192807314 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|192807312 SWI/SNF-related matrix-associated actin-dependent r... 34 0.49
gi|21071056 SWI/SNF-related matrix-associated actin-dependent re... 34 0.49
gi|154146216 pleckstrin homology domain containing, family A (ph... 34 0.49
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 34 0.64
gi|217416392 pleckstrin homology domain containing, family H (wi... 33 0.84
>gi|22003858 ventricular zone expressed PH domain homolog 1 [Homo
sapiens]
Length = 833
Score = 1652 bits (4277), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEI 60
MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEI
Sbjct: 1 MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEI 60
Query: 61 CITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNY 120
CITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNY
Sbjct: 61 CITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNY 120
Query: 121 NRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTM 180
NRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTM
Sbjct: 121 NRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTM 180
Query: 181 LLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPF 240
LLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPF
Sbjct: 181 LLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPF 240
Query: 241 LIGHLKDSTHNDIILNILMEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHV 300
LIGHLKDSTHNDIILNILMEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHV
Sbjct: 241 LIGHLKDSTHNDIILNILMEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHV 300
Query: 301 DEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIA 360
DEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIA
Sbjct: 301 DEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIA 360
Query: 361 KLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGS 420
KLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGS
Sbjct: 361 KLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGS 420
Query: 421 NTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLS 480
NTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLS
Sbjct: 421 NTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLS 480
Query: 481 EIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASP 540
EIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASP
Sbjct: 481 EIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASP 540
Query: 541 IEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCL 600
IEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCL
Sbjct: 541 IEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCL 600
Query: 601 YSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETA 660
YSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETA
Sbjct: 601 YSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETA 660
Query: 661 MMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIE 720
MMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIE
Sbjct: 661 MMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIE 720
Query: 721 GKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRR 780
GKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRR
Sbjct: 721 GKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRR 780
Query: 781 DRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL 833
DRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL
Sbjct: 781 DRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL 833
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 13/116 (11%)
Query: 716 QPLIEGKLKEKQVRWKFIKR-----WKTRYFTLAGNQLLFQKGKSKDDPD-----DCPIE 765
Q +EG L KQ F K+ W+ Y L L F K + P+
Sbjct: 2218 QEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVS 2277
Query: 766 LSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQA 821
L++ Q A ++R + D K Y+F+AKDE + WL+ +N A+A A
Sbjct: 2278 LARAQGSVAFDYRKRKHVFKLGLQ---DGKEYLFQAKDEAEMSSWLRVVNAAIATA 2330
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 6/95 (6%)
Query: 734 KRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTD 793
K W R+F++ NQL++QK K KD+P +L K D FE+ +
Sbjct: 282 KTWNRRWFSIQNNQLVYQK-KFKDNPTVVVEDLR-----LCTVKHCEDIERRFCFEVVSP 335
Query: 794 NKTYVFKAKDEKNAAEWLQCINVAVAQAKERESRE 828
K+ + +A EK W++ + ++A A + E
Sbjct: 336 TKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDE 370
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 733 IKRWKTRYFTLAGNQLLFQKGKSKDDP-DDCPI-ELSKVQSVKAVAKKRRDRSLPRAFEI 790
+K WK RYF L N + + K + + +P P+ E+ KVQ K RD FEI
Sbjct: 205 MKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRD----NLFEI 260
Query: 791 FTDNKTYVFKAKDEKNAAEWLQCINVAV 818
T ++T+ +A + W++ ++ A+
Sbjct: 261 VTTSRTFYVQADSPEEMHSWIKAVSGAI 288
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 733 IKRWKTRYFTLAGNQLLFQKGKSKDDP-DDCPI-ELSKVQSVKAVAKKRRDRSLPRAFEI 790
+K WK RYF L N + + K + + +P P+ E+ KVQ K RD FEI
Sbjct: 205 MKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRD----NLFEI 260
Query: 791 FTDNKTYVFKAKDEKNAAEWLQCINVAV 818
T ++T+ +A + W++ ++ A+
Sbjct: 261 VTTSRTFYVQADSPEEMHSWIKAVSGAI 288
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 38.9 bits (89), Expect = 0.020
Identities = 23/88 (26%), Positives = 43/88 (48%), Gaps = 6/88 (6%)
Query: 734 KRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTD 793
K W R+FT+ NQL++Q K DP ++ ++ +VK R FE+ +
Sbjct: 281 KTWSRRWFTIQSNQLVYQ--KKYKDPVTVVVDDLRLCTVKLCPDSER----RFCFEVVST 334
Query: 794 NKTYVFKAKDEKNAAEWLQCINVAVAQA 821
+K+ + +A E+ W+ + ++A A
Sbjct: 335 SKSCLLQADSERLLQLWVSAVQSSIASA 362
>gi|20149626 pleckstrin homology domain containing, family O member
1 [Homo sapiens]
Length = 409
Score = 38.5 bits (88), Expect = 0.026
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 732 FIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPI-------ELSKVQSVKAVAKKRRDR-S 783
F + WK RY L G+QL + + KD+ + + + +++ K+ +KK + +
Sbjct: 37 FREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFT 96
Query: 784 LPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVT 830
L + + +F A + W+ +N A+ +AK R EVT
Sbjct: 97 LAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVT 143
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 38.1 bits (87), Expect = 0.034
Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%)
Query: 788 FEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL 833
FE+ T+N+T+ F+A+ + EW+Q + A+A+ + R +R + YL
Sbjct: 143 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRAR-ARLSSAYL 187
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 38.1 bits (87), Expect = 0.034
Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%)
Query: 788 FEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL 833
FE+ T+N+T+ F+A+ + EW+Q + A+A+ + R +R + YL
Sbjct: 143 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRAR-ARLSSAYL 187
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 38.1 bits (87), Expect = 0.034
Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 1/46 (2%)
Query: 788 FEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVTTYL 833
FE+ T+N+T+ F+A+ + EW+Q + A+A+ + R +R + YL
Sbjct: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRAR-ARLSSAYL 432
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 37.7 bits (86), Expect = 0.044
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 13/124 (10%)
Query: 711 VNQDGQPLIEGKLKEKQV--RWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSK 768
V+ GQ + +KE Q+ + +RWK RYF L G L + K D+ ++LS
Sbjct: 55 VSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDE--VDLSD 112
Query: 769 VQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESRE 828
+A K + +F I T + + A++ K +W+ ++ + RE E
Sbjct: 113 ASVAEASTKNANN-----SFTIITPFRRLMLCAENRKEMEDWIS----SLKSVQTREPYE 163
Query: 829 VTTY 832
V +
Sbjct: 164 VAQF 167
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 37.7 bits (86), Expect = 0.044
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 13/124 (10%)
Query: 711 VNQDGQPLIEGKLKEKQV--RWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSK 768
V+ GQ + +KE Q+ + +RWK RYF L G L + K D+ ++LS
Sbjct: 55 VSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDE--VDLSD 112
Query: 769 VQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESRE 828
+A K + +F I T + + A++ K +W+ ++ + RE E
Sbjct: 113 ASVAEASTKNANN-----SFTIITPFRRLMLCAENRKEMEDWIS----SLKSVQTREPYE 163
Query: 829 VTTY 832
V +
Sbjct: 164 VAQF 167
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
[Homo sapiens]
Length = 1701
Score = 37.7 bits (86), Expect = 0.044
Identities = 47/193 (24%), Positives = 80/193 (41%), Gaps = 18/193 (9%)
Query: 638 SVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAW 697
S Q L E T A G+ + E+ F ++ ++ + E SE+ +
Sbjct: 435 STQILSQRSESTHAIGSDPLRQNIYEN-FMRELEMSRTNTENIETSTETAESSSESLSSL 493
Query: 698 QCFMCNNPEKATVVNQDG----QPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQK- 752
+ ++ VV + G +PL+ + KE+++ ++WK + TL G LLF +
Sbjct: 494 EQLDLLFEKEQGVVRKAGWLFFKPLVTVQ-KERKLELVARRKWKQYWVTLKGCTLLFYET 552
Query: 753 -GKSKDDPDDCP-----IELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKN 806
GK+ D P E S VQSV KK L +F Y+F+A + +
Sbjct: 553 YGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSF-----GDVYLFQATSQTD 607
Query: 807 AAEWLQCINVAVA 819
W+ ++ A A
Sbjct: 608 LENWVTAVHSACA 620
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 37.7 bits (86), Expect = 0.044
Identities = 25/91 (27%), Positives = 50/91 (54%), Gaps = 9/91 (9%)
Query: 733 IKRWKTRYFT-LAGNQLLFQKGKSKDDPDDCPIEL--SKVQSVKAVAKKRRDRSLPRAFE 789
++ +K + FT L+GN + K + +D I + V +VK V DR++ ++FE
Sbjct: 596 LRGYKAKIFTVLSGNSVWLCKNE-QDFKSGLGITIIPMNVANVKQV-----DRTVKQSFE 649
Query: 790 IFTDNKTYVFKAKDEKNAAEWLQCINVAVAQ 820
I T +++ F A+ EK +W++ + ++A+
Sbjct: 650 IITPYRSFSFTAETEKEKQDWIEAVQQSIAE 680
Score = 30.4 bits (67), Expect = 7.1
Identities = 13/45 (28%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 788 FEIFTDNKTYVFKAKDEKNAAEWLQ-CINVAVAQAKERESREVTT 831
FE+ T +T+VF+ + E+ +W+ +N +Q+ +S+ V T
Sbjct: 543 FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT 587
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 37.7 bits (86), Expect = 0.044
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 14/92 (15%)
Query: 734 KRWKTRYFTLAGNQLLFQKGKSKDD----PDDCPIELSKVQSVKAVAKKRRDRSLPRAFE 789
K W R+F++ +QL++QK K KD DD + L V+ + + ++ FE
Sbjct: 284 KTWNRRWFSIQNSQLVYQK-KLKDALTVVVDD--LRLCSVKPCEDIERRF-------CFE 333
Query: 790 IFTDNKTYVFKAKDEKNAAEWLQCINVAVAQA 821
+ + K+ + +A EK W+Q + ++A A
Sbjct: 334 VLSPTKSCMLQADSEKLRQAWVQAVQASIASA 365
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 36.6 bits (83), Expect = 0.099
Identities = 23/92 (25%), Positives = 46/92 (50%), Gaps = 5/92 (5%)
Query: 733 IKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFT 792
+K WKTR+FTL N+L + K + +P ++L++ +V+ + R F
Sbjct: 178 VKTWKTRWFTLHRNELKYFKDQMSPEPIRI-LDLTECSAVQFDYSQERVNCFCLVFPF-- 234
Query: 793 DNKTYVFKAKDEKNAAEWLQCINVAVAQAKER 824
+T+ AK A EW++ + ++Q +++
Sbjct: 235 --RTFYLCAKTGVEADEWIKILRWKLSQIRKQ 264
>gi|134142826 pericentriolar material 1 [Homo sapiens]
Length = 2024
Score = 36.2 bits (82), Expect = 0.13
Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 24/201 (11%)
Query: 373 GSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFE-DKINAGSNTPGSIRRYSL 431
G GRR+ T FP +++ V E + EKL+ +I + D+ + GS++ G +
Sbjct: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANN 130
Query: 432 GQVSKEERKNIRF-------NRSKSLAFHTMLTKGVGSDDGED----ENRGDIPASISLS 480
+ E RK F N+SK + + +GS ++ D+ + +S
Sbjct: 131 KRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVS 190
Query: 481 EIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASP 540
E D G+G + E SQ+ V + I S + V++N + E
Sbjct: 191 EED--GRGEPAM------ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHL 242
Query: 541 IEY---QDKLYL-HLKKNLSK 557
I++ Q+K Y+ LKK L++
Sbjct: 243 IDHLKEQEKSYMKFLKKILAR 263
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 35.4 bits (80), Expect = 0.22
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 30/111 (27%)
Query: 733 IKRWKTRYFTLAGNQL-LFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIF 791
+K WK R+F L N L F+ K+ P+E ++ V+ D P FE++
Sbjct: 274 VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE-------DSKKPNCFELY 326
Query: 792 -TDNKTYVFKA-KDE--------------------KNAAEWLQCINVAVAQ 820
DNK V KA K E + EW++CI A+++
Sbjct: 327 IPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 377
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 35.4 bits (80), Expect = 0.22
Identities = 30/111 (27%), Positives = 46/111 (41%), Gaps = 30/111 (27%)
Query: 733 IKRWKTRYFTLAGNQL-LFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIF 791
+K WK R+F L N L F+ K+ P+E ++ V+ D P FE++
Sbjct: 275 VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE-------DSKKPNCFELY 327
Query: 792 -TDNKTYVFKA-KDE--------------------KNAAEWLQCINVAVAQ 820
DNK V KA K E + EW++CI A+++
Sbjct: 328 IPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 378
>gi|4503917 growth arrest-specific 8 [Homo sapiens]
Length = 478
Score = 34.7 bits (78), Expect = 0.38
Identities = 63/309 (20%), Positives = 134/309 (43%), Gaps = 42/309 (13%)
Query: 167 TEVIVKSILQGNTMLLRVLPAVYEKQPQPIN-RHLTELLALMSQLEQPEQYHLLRLLHVA 225
+EV+VK++ +T + + +E+Q + I ++ ++ L +L+ + L H
Sbjct: 156 SEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEL----HEV 211
Query: 226 AKKK--QLEVVQKCIPFLIGHLKDSTHNDIILNILMEIAVYEPVALNSFLPMLKEIGERF 283
++K Q+ + + +K+ +NDI LN L +NS ++++ ++
Sbjct: 212 EERKNGQIHTLMQRHEEAFTDIKNY-YNDITLNNL--------ALINSLKEQMEDMRKKE 262
Query: 284 PYLTGQMARIYGAVGHVDE--ERARSCLTYLVSQLANMEHSFHHILLL------------ 329
+L +MA + G + + ++AR ++ + QLAN E +L
Sbjct: 263 DHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK 322
Query: 330 ----EIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQ--LENTKAGSGRRKISTEI 383
E + + F+ + Q RD + FTA + + ++ +N + +S +
Sbjct: 323 DLQWEHEVLEQRFTKV--QQERD--ELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAV 378
Query: 384 EFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIR 443
E E ++ +++ N D L + + ED + + ++T ++ Y L QV K +R
Sbjct: 379 EKKE-VQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQ-YELAQVCKAHNDLLR 436
Query: 444 FNRSKSLAF 452
+K LAF
Sbjct: 437 TYEAKLLAF 445
>gi|192807323 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform A [Homo sapiens]
Length = 1679
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|192807320 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform F [Homo sapiens]
Length = 1613
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|192807318 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform E [Homo sapiens]
Length = 1614
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|192807316 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform D [Homo sapiens]
Length = 1616
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|192807314 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform C [Homo sapiens]
Length = 1617
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|192807312 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform B [Homo sapiens]
Length = 1647
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|21071056 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a4 isoform B [Homo sapiens]
Length = 1647
Score = 34.3 bits (77), Expect = 0.49
Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 20/242 (8%)
Query: 346 SRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKL 405
++D S T + LT+ + A + R + E E EK +L+ + E + KL
Sbjct: 483 AKDFKEYHRSVTGKIQKLTKAVATYHANTEREQ-KKENERIEKERMRRLMAEDEEGYRKL 541
Query: 406 QVKIQAFEDKINAG---------SNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTML 456
I +DK A +N +R++ QV+KE++K + ++++ T
Sbjct: 542 ---IDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPA 598
Query: 457 TKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHI 516
G E D+P + E + G D K + L E + Y
Sbjct: 599 IGPDGEPLDETSQMSDLPVKVIHVESGKILTGTDAP--KAGQLEAWL-EMNPGYEVAPRS 655
Query: 517 DSENL-SETVKENSQEETPETT---ASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVP 572
DSE SE +E +EE P+ P+E + K+ ++S+V A + K V
Sbjct: 656 DSEESGSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVD 715
Query: 573 DQ 574
D+
Sbjct: 716 DE 717
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 34.3 bits (77), Expect = 0.49
Identities = 29/116 (25%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 715 GQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKA 774
G PLI+ KQ + K WK R+F L + + K + +P +++ +
Sbjct: 196 GPPLIKSGYCVKQGNVR--KSWKRRFFALDDFTICYFKCEQDREPLRTIFLKDVLKTHEC 253
Query: 775 VAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVT 830
+ K FEI T ++T+ +A ++ W++ I AV QA + RE +
Sbjct: 254 LVKSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAV-QALKCHPRETS 308
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 33.9 bits (76), Expect = 0.64
Identities = 45/198 (22%), Positives = 83/198 (41%), Gaps = 33/198 (16%)
Query: 632 LSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFS 691
L++ S +VQ L +L + A S+ E F +QK D V+ F D+ S
Sbjct: 512 LTLISKTVQTLGSLSKSKSASFKESYMATFYEF-FNEQKYADAVK------NFLDLISSS 564
Query: 692 ETAGAWQCFMCNNPEKATVVNQDGQPLI--EG-KLKEKQVRWKF-IKRWKTRYFTLAGNQ 747
+P+ QP++ EG +K Q R +F +K +K R+F L ++
Sbjct: 565 GR---------RDPKSVE------QPIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHE 609
Query: 748 LLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDR-SLPRAFEIFTDNKTYVFKAKDEKN 806
+ K K D P+ ++++ AV K + + F++ + +A +
Sbjct: 610 FTYHKSKG-----DQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQANNCVE 664
Query: 807 AAEWLQCINVAVAQAKER 824
A +W+ I V+Q ++
Sbjct: 665 AKDWID-ILTKVSQCNQK 681
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 33.5 bits (75), Expect = 0.84
Identities = 29/93 (31%), Positives = 41/93 (44%), Gaps = 13/93 (13%)
Query: 733 IKRWKTRYFTLAGNQLLFQKGKSKDDPDDCP---IELSKVQSVKAVAKKRRDRSLPRAFE 789
+K WK R+F L G +LL+ KS D P IELS S+ K + +
Sbjct: 717 VKSWKRRWFVLKGGELLYY--KSPSDVIRKPQGHIELSASCSILRGDNK-------QTVQ 767
Query: 790 IFTDNKTYVFKAKDEKNAAEWLQCI-NVAVAQA 821
+ T+ TY A EW++ + NV QA
Sbjct: 768 LTTEKHTYYLTADSPNILEEWIKVLQNVLRVQA 800
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,028,507
Number of Sequences: 37866
Number of extensions: 1311561
Number of successful extensions: 3853
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 3809
Number of HSP's gapped (non-prelim): 93
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.