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Search of human proteins with 21735548
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735548 centrosomal protein 2 [Homo sapiens]
(2442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735548 centrosomal protein 2 [Homo sapiens] 4597 0.0
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 708 0.0
gi|148746195 trichohyalin [Homo sapiens] 322 2e-87
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 296 2e-79
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 289 3e-77
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 286 2e-76
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 286 2e-76
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 286 2e-76
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 286 2e-76
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 286 2e-76
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 286 2e-76
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 286 2e-76
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 286 2e-76
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 282 2e-75
gi|55770834 centromere protein F [Homo sapiens] 265 3e-70
gi|71061468 centromere protein E [Homo sapiens] 262 3e-69
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 252 3e-66
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 239 2e-62
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 228 6e-59
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 219 2e-56
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 214 1e-54
gi|148536869 ninein isoform 2 [Homo sapiens] 213 2e-54
gi|33946313 ninein isoform 4 [Homo sapiens] 212 3e-54
gi|33946321 ninein isoform 5 [Homo sapiens] 212 3e-54
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 210 2e-53
gi|81295809 pericentrin [Homo sapiens] 210 2e-53
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 207 1e-52
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 207 1e-52
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 207 1e-52
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 207 1e-52
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 4597 bits (11923), Expect = 0.0
Identities = 2442/2442 (100%), Positives = 2442/2442 (100%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ
Sbjct: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
Query: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL 120
AKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL
Sbjct: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL 120
Query: 121 RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSL 180
RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSL
Sbjct: 121 RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSL 180
Query: 181 WREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG 240
WREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG
Sbjct: 181 WREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG 240
Query: 241 REPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE 300
REPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE
Sbjct: 241 REPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE 300
Query: 301 DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA 360
DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA
Sbjct: 301 DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA 360
Query: 361 QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ
Sbjct: 361 QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
Query: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480
QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE
Sbjct: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480
Query: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540
VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS 540
Query: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK
Sbjct: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK
Sbjct: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
Query: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
Query: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840
SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG 840
Query: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA
Sbjct: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
Query: 961 KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV
Sbjct: 961 KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080
AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080
Query: 1081 ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140
ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA
Sbjct: 1081 ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140
Query: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200
SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR
Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200
Query: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD 1260
PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD
Sbjct: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD 1260
Query: 1261 VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320
VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE
Sbjct: 1261 VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320
Query: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
Query: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500
RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE
Sbjct: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500
Query: 1501 QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560
QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL
Sbjct: 1501 QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560
Query: 1561 ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV
Sbjct: 1561 ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
Query: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680
LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680
Query: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC
Sbjct: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
Query: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS 1800
QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS 1800
Query: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE 1860
LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE 1860
Query: 1861 LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920
LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE
Sbjct: 1861 LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920
Query: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR 2160
LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR
Sbjct: 2101 LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR 2160
Query: 2161 QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR 2220
QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR
Sbjct: 2161 QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR 2220
Query: 2221 ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVA 2280
ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVA
Sbjct: 2221 ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVA 2280
Query: 2281 RLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG 2340
RLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG
Sbjct: 2281 RLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG 2340
Query: 2341 QKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQ 2400
QKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQ
Sbjct: 2341 QKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQ 2400
Query: 2401 APEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR 2442
APEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR
Sbjct: 2401 APEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR 2442
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 708 bits (1828), Expect = 0.0
Identities = 572/1916 (29%), Positives = 945/1916 (49%), Gaps = 225/1916 (11%)
Query: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL-E 78
L Q + L++Q+ E QA+ RKL+ QE QQRQA LV++LQ K+LQY+ C ELE++L E
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
Query: 79 ATGGPIPQRWENVEEP-NLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRED 137
+G QR + E +L+ L+RLEEEQQR SLA+VN LR +++A N+AL ED
Sbjct: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
Query: 138 VEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA 197
+ K+T DW+R R EL +E+ W+ E+E F Y EH RLL LWR+VV FRR E+K
Sbjct: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
Query: 198 TDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELE 257
T+RDL++L E R S ++ L L+ G + E ++ + LL A+ +E
Sbjct: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE-----KQALLQAQLEEQL 371
Query: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
++ R ++L Q + Q DL+KA+L RVTEL + + +KQN + +++ K L E +E LE
Sbjct: 372 RDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALE 431
Query: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFS 377
+ ++ +A+L E+ LQQ ++D+ Q ++ + ++ Q SG E + + +
Sbjct: 432 SLR---LQEQAALE---TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLR 485
Query: 378 QFDYQ-------------------------DADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Q L L+ S L +R+ VQD+R +
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEAS 545
Query: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
Q+ + L++Q E E +AL ++LQ+L + D D Q EV L ELL + +
Sbjct: 546 QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREK 605
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV-------RERERLQ 525
L L+V +Q+A LR+ +LQ + + Q++ +EE AV RE ER
Sbjct: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
Query: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
L LE K+S EL+ +REAL + L+ ++L+ E+ EV AL +AE EL S
Sbjct: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
Query: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
L+ E A L+ + KLSALNE+LA DK+ LN+ + QLEEE ++ R AEQ +
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
Query: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
+ E+ R LE L+ AE+A L+ L ++ E+ ++Q++L++ Q
Sbjct: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Query: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
+LEQ +EA+RQ E L RA +EKEAL +E A L V+L A ER+ + L+E+ L
Sbjct: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
Query: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
KE LE SLFE Q+Q + +E + QLE + Q + AKE + GE+ L+ ++ + +A +
Sbjct: 906 KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLD 965
Query: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA-LES-LERE 883
++ A++L QAE+E + +L +Q+AAHE+++ +L+ EKE +W + E +A L+S L+RE
Sbjct: 966 KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR--EKEAAWRELEAERAQLQSQLQRE 1023
Query: 884 KMELEMRLKEQQTEME----AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939
+ EL RL+ ++ E+ A+Q +R+E AES Q E E+ +L E L+ T+
Sbjct: 1024 QEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRH 1083
Query: 940 ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999
LA S ++ER ++D + ++ +++ T L ++L++ + + +EAA H ++ LQE++
Sbjct: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQAR 1143
Query: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV---QEKLRETQEYNRIQ--------- 1047
L + + ++ E+L++QL +D++ + +E+ Q KLRE+QE +Q
Sbjct: 1144 DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
Query: 1048 -----------------------KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
K+ E E+ SL L+ +KEQ+L +L+EA + +E
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 1085 LRQDMQ-------EAQGEQKELSAQM---------------------------------- 1103
LR +Q EA+ E +EL QM
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 1104 ---------------ELLRQEVKEKEADFLAQEAQ-------LLEELEASHITEQQ---- 1137
E++RQE++ + QE + LL LE + TE+Q
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383
Query: 1138 ---LRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQAQAQLASLYSALQQA 1192
L L A A+AA+L LRL + E + + L AE + + A+AQL L SAL++
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
Query: 1193 L--------------GSVCESRP-ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
L GS P E SG G ++PS P P L
Sbjct: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
Query: 1238 AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
EAV AL + Q+L Q+ RD LR Q L +L + EAE+ + + LQ+ ++++
Sbjct: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
Query: 1298 QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQV 1357
+E + +G+ + +++EL L E R RRA L ++ A ER LQA + L A
Sbjct: 1564 EEARRSVDGRLSGVQAEL-ALQEESVRRSERERRATLDQV-ATLERS-LQATESELRASQ 1620
Query: 1358 EHLQAAVVEARAQASAAGILEEDLRTARS---ALKLKNEEVESERERAQALQEQGELKVA 1414
E + L+E L + S L+L+ +E E +R++ E A
Sbjct: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE---A 1677
Query: 1415 QGKALQENLALLTQTLAEREEE-------VETLRGQIQELEKQREMQKAALELLSLDLKK 1467
Q +ALQ+ + L + +A+ E + VE L G + ++E+ + + L+ L +
Sbjct: 1678 QAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQ 1737
Query: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET---QRNVL 1524
+ ++ +++ L+K + EH +QER L R+ + E K + Q L
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDRQVLQER---LDAARQALSEARKQSSSLGEQVQTL 1794
Query: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
++ +LE + E Q Q++++ +Q E AL + K++ +++L++E G
Sbjct: 1795 RGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ---KLQDERRLLQERLG--- 1848
Query: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQR 1644
+L LE +E++ + + LE L R L + ++E E L
Sbjct: 1849 ----SLQRALAQLEAEKREVERSALR---LEKDRVALRRTLDKVEREKLRSHEDTVRLSA 1901
Query: 1645 QKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQ 1704
+K L + L + EL + +IQ LE Q +LE+ +L + + ++L Q++
Sbjct: 1902 EKGRLDRTLTGAELELAEAQRQIQQLE----AQVVVLEQSHSPAQLEVDAQQQQLELQQE 1957
Query: 1705 LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
+ + R+ + + +LE + R + + +E ++ LK QL+Q+L+
Sbjct: 1958 VERLRSAQAQ-----TERTLEARERAHRQRVRGLE------EQVSTLKGQLQQELR 2002
Score = 292 bits (747), Expect = 3e-78
Identities = 473/2023 (23%), Positives = 826/2023 (40%), Gaps = 341/2023 (16%)
Query: 262 ERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHT 321
ER ++ ++L+ G+LE E + V + L Q Q++ Y + ++A +E
Sbjct: 116 ERLEQALRLEP-GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEG--------- 165
Query: 322 ELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS--GHENSLELDSSIFSQF 379
+ +A L + Q + L ++ ++ Q ++E + Q E+S +L+S++
Sbjct: 166 --QQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
Query: 380 DYQDADKALTLVRSVLTRR-------RQAV-QDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431
+ Q +L V ++L + QA+ +D+R+ L+ + W E +
Sbjct: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE 283
Query: 432 ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK--ERELLQKAREELRQQLEVLE-----Q 484
+ L Q V + V + ER+LLQ E R V E
Sbjct: 284 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 343
Query: 485 EAWRLRRVNVELQLQGDSA-QGQKEEQQEELHLAVRERERLQEML--------------- 528
RL E L+ + Q Q EEQ + L RE++ Q+ +
Sbjct: 344 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVL--REKDLAQQQMQSDLDKADLSARVTE 401
Query: 529 MGLEAKQSESLS--------ELITLREALESSHLE---------GELLRQEQTEVTAALA 571
+GL K+ E + +L EALES L+ GE L+Q ++ A+
Sbjct: 402 LGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVL 461
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-----------------------NEAL 608
+S +LS SE T LR + + + + L
Sbjct: 462 SDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521
Query: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
AL L+++ LQ+ Q + R EA++ L+ L+++E R AL E+ L +
Sbjct: 522 ALIHSALHKRQLQV----QDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT 577
Query: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR----QEEVL 724
A +A + Q +++ ++ E + ++ S H + A Q E+L QE ++ QEE+
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 725 A---RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSS--AKELLE--SSLFEAQ 777
R +E+E V++ A + L ER + L EQL+G S AKEL+E +L A
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRREL---ERSHRQL-EQLEGKRSVLAKELVEVREALSRAT 693
Query: 778 QQNSVIEVTK------------GQLEVQIQ-TVTQAKEV-IQGEVRCL----------KL 813
Q +++ K G++E+++ T +A+E +Q + L KL
Sbjct: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Query: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE----------------KEVNQ 857
+L+ +Q E+E+ A + QAEQE A E+Q+ E + Q
Sbjct: 754 DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQ 813
Query: 858 LREKWEK-------ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ-AQREEER 909
+E E+ ERS Q++LA+ L + ELE +E Q ++EA++ A RE+E
Sbjct: 814 AQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA 873
Query: 910 TQAESALCQMQLETEK---------------ERVSLLETLLQTQKELADASQQLERLRQD 954
E A +QL + E+ +L +L + Q++LA + E+L +
Sbjct: 874 LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Query: 955 MKVQKLKEQETTG--------ILQTQLQ-----------------EAQRELKEAARQHRD 989
+ L ++ TG I+ TQ + EAQ L+E H +
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 990 DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKE 1049
DL LQ E + ++ L+ + L+SQL Q + + L+ + EK ++E +Q+E
Sbjct: 994 DLQRLQREKEAAWRE---LEAERAQLQSQL--QREQEELLARLEAEKEELSEEIAALQQE 1048
Query: 1050 LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
+ L L+ EK+Q L S+++ E +AL + + + +S +ME +++
Sbjct: 1049 RDE---GLLLAESEKQQAL-------SLKESEKTALSEKLMGTRHSLATISLEMERQKRD 1098
Query: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
+ ++ + L EL ++ A+ AQE + +LQ + R Q ++ E
Sbjct: 1099 AQSRQEQDRSTVNALTSELRDLRAQREEAAAA-HAQEVR--RLQEQARDLGKQRDSCLRE 1155
Query: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
+ + + QL L A + E++ +L + G E + A L +R
Sbjct: 1156 AE-----ELRTQLRLLEDARDGLRRELLEAQRKLRESQE------GREVQRQEAGEL-RR 1203
Query: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLR----DQVQKL---EERLTDTEAEKSQ 1282
A EA+ + +L + K + R L+ D+ QKL EE T E +
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL---RRAELQ-RME 1338
+ T LQ+++R + + E + + L+SE L +A LQ RL RAE + R E
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
G R+ L + +L + LQ A + + Q E + RT L EE
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQ-------EGEFRTRERRLLGSLEEARGT 1376
Query: 1399 RERAQALQEQG-ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
E+ Q +G ELK+ +A L L L+ E + L ++ +E QR +A
Sbjct: 1377 -EKQQLDHARGLELKLEAARAEAAELGL---RLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432
Query: 1458 LELLSLDLKKR----------------NQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
L L L++ + D E E S LE P +
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE 1561
T + D E R L L EL + + R Q L +QL +E E
Sbjct: 1493 PATSPASP----DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA---E 1545
Query: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
+ + QK + E E R + L+ + +L + + ++ + L
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL 1681
R LQ + E+++ +E+I +++ + L D R + L + R LE QR + L
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQR----RSL 1661
Query: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGK---GPSKAQRGSLEHMKLILRDKEKEV 1738
E +L++ +L L +R Q Q +Q+R + + S+ + G+L+ V
Sbjct: 1662 EGELQRSRLGLSDR----EAQAQALQDRVDSLQRQVADSEVKAGTLQ----------LTV 1707
Query: 1739 ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798
E + +++E + L +++GL + ++S L+ + + LQ+ L E
Sbjct: 1708 ERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC----EHDR 1763
Query: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Q LQ +LD A++AL++ A+ Q + E+ L+G + + E
Sbjct: 1764 QVLQERLDAARQALSE--------------ARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809
Query: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE-QAQEH 1917
G+LQ +E R+ +E A VQ L++ E R ++ L +LQ+ A+ +A++
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQD-------ERRLLQERLGSLQRALAQLEAEKR 1862
Query: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL 1977
EVE AL+ L+ V R + + E + R E+ R AE G+ L
Sbjct: 1863 EVERSALR---LEKDRVALRRTLD----KVEREKLRSHEDTVRLSAEK-----GRLDRTL 1910
Query: 1978 QGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDV 2037
G E L E + LEA L+ S Q E + Q Q L Q++V
Sbjct: 1911 TGAELELAEAQRQIQQLEAQVVVLEQSHSPAQL------------EVDAQQQQLELQQEV 1958
Query: 2038 QQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNL 2080
++L+ A AQ + L ++ + + L ++V Q +Q L
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Score = 289 bits (739), Expect = 3e-77
Identities = 485/2067 (23%), Positives = 879/2067 (42%), Gaps = 323/2067 (15%)
Query: 334 AQEEKLSLQQVIKDI-TQVMVEE----GDNIAQGSGHENSLELDSSIFSQFDYQDADKAL 388
AQE +L+L+ VI+ + + V+ +E ++AQ + + L I ++ Q L
Sbjct: 8 AQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVL 67
Query: 389 ---TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT---- 441
T + S+L+ + + Q L+Q+L+ ++ + + + D+ + A+ +RL++
Sbjct: 68 LPATEMASLLSLQEEN-QLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEP 126
Query: 442 GERDT-----LAGQTVDL----QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
GE +T L Q+V+L Q E S ++ + Q+ ++ Q ++ L+ + + ++
Sbjct: 127 GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
Query: 493 NVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGL-----EAKQSESLSEL-ITLR 546
EL+ Q G+ E+Q+ +R+ E Q++ L E ++S SL+++ LR
Sbjct: 187 CSELEQQLLERSGELEQQR------LRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240
Query: 547 EALESSHLEGELLRQEQTEVT--------------AALARAEQSIAELSSSENT----LK 588
E L+ + + L ++ +VT AA R E+S S+E++ L
Sbjct: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Query: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA 648
+V R ++ E + LLQL E + A ++A L L
Sbjct: 301 RQVVGFRRLVSEVKMFTE----------RDLLQLGGE---LARTSRAVQEAGLGLSTGLR 347
Query: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
AE R EA EK L+AQL++ + DL Q + + + LS + A
Sbjct: 348 LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407
Query: 709 QLEQLHQEAKRQEEVLARAVQEKEAL-VREKAALEVRL-QAVERDRQDLAEQLQGLSSAK 766
+LE+ + E + + L ++ E+L ++E+AALE + +++ +DLA+ + S +
Sbjct: 408 RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESG 467
Query: 767 ELLESSLFEAQQQNSVIEVTKGQL------------------------------------ 790
L S A N + GQ
Sbjct: 468 VQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSA 527
Query: 791 ----EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
++Q+Q + E Q + L+ +L S +E ER A QL + + A++
Sbjct: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQL----SDSESERRALEEQLQRLRDKTDGAMQA 583
Query: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR- 905
+ A ++EV +LR E S + LA +L+ +++ EL ++ Q E ++ QR
Sbjct: 584 HEDA-QREVQRLRSANEL-LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 906 --EEERTQA--ESALCQMQLETEKERVSLLETLLQT-QKELADASQQLER--LRQDM--- 955
EEE+ A + A + +LE ++ LE KEL + + L R L++DM
Sbjct: 642 RLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQA 701
Query: 956 ---KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012
+V + + G ++ +L + +EA+ Q D L+ L + SL QDK+DL + V
Sbjct: 702 EKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ--DSLSKLSALNESLAQDKLDLNRLV 759
Query: 1013 EDLKSQLVAQDDSQRLVEQE--VQEKLRETQEYNRIQKELEREKASLTLSLMEK-----E 1065
L+ + A QR EQE V + +E E R+++E+ R+ +L + E+ E
Sbjct: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
Query: 1066 QRLLVLQEADSIRQQELSALRQDM----QEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Q+L L+ S Q++L+ L + + QE + ++E Q+E L + +EKEA LA+E
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA--LAKE 877
Query: 1122 -----AQLLE-ELEASHITEQ--QLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173
QL+ E E ++E+ +LR A E ++Q +L E++ E L AE Q
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ-- 935
Query: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
+L A + G + R ++ + A L+ + + +
Sbjct: 936 ----------ALLLAKETLTGELAGLRQQIIATQEKA----SLDKELMAQKLVQAEREAQ 981
Query: 1234 TALSAEAVA-----SALHKLHQDLWKTQQT-RDVLRDQVQK-LEERLTDTEAEKSQVHTE 1286
+L + A L + + W+ + R L+ Q+Q+ EE L EAEK ++ E
Sbjct: 982 ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEE 1041
Query: 1287 LQDLQRQL--------SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
+ LQ++ S+ Q+ S E ++ +L +LM ++A++ + R Q+ +
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER---QKRD 1098
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
AQ +E ++ LT+++ L+A EA A + +EV
Sbjct: 1099 AQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA--------------------QEVRRL 1138
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
+E+A+ L +Q + + + + L+ L LL E+ + +++E ++ RE+Q+
Sbjct: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
Query: 1459 ELLSLDLKKRNQEVDLQQEQIQEL----EKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
L L + +E + + +EL +K S L +A +++EQKL + E +
Sbjct: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG 1258
Query: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC----LALELEENHHKME 1570
K+ R L+ E + +E++R ++Q+L++Q+ L+ L EL E ++
Sbjct: 1259 KEAGELRTGLQ------EVERSRLEARR-ELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL----Q 1626
++ KE + R L LE QELQ ++ + E R L +
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLE 1371
Query: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR---QTKILEE 1683
E K Q + L+ + E + L + R Q LE + R Q + E
Sbjct: 1372 EARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
Query: 1684 DLEQIKLSLRERGREL-------------TTQRQLMQERAEEG----------------- 1713
L ++ +LR RG L + R E + EG
Sbjct: 1432 QLGGLRSALR-RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490
Query: 1714 KGPS----------KAQRGSLEHMKLILRDKEKE-------VECQQEHIHELQELKDQLE 1756
GP+ +A RG+L LR ++E + E++ +D
Sbjct: 1491 PGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSAT 1550
Query: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA---QRALA 1813
+ + L + V E+ + + +Q +L E E+ ++ LD+ +R+L
Sbjct: 1551 SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQ 1610
Query: 1814 QRDQELEALQQE-------QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ---- 1862
+ EL A Q++ + + +G + R+KE DA + + + + GELQ
Sbjct: 1611 ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL 1670
Query: 1863 ---DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
D + QA+ L++ + R+V E G L+ AL +++ +E A +V
Sbjct: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE--SEGALRDKV 1728
Query: 1920 ETRALQDSWLQAQAVLKE-RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978
R L ++ Q+ A L RD+ L +A + + H + + R +A ++AL +A
Sbjct: 1729 --RGLTEALAQSSASLNSTRDKNLHLQKALT-ACEHDRQVLQERLDAARQALSEARK--- 1782
Query: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI-QEGE---------IQD 2028
+ L EQ + +L A L+ + +QL E LR QEGE +QD
Sbjct: 1783 -QSSSLGEQVQ---TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838
Query: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088
+ QE + LQ+ALAQ + E R + LEK RV +K + R E+
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD---RVALRRTLDKVEREKLRSHED 1895
Query: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL 2148
L L TL E E+ E + Q+ + + SP + L++D+ + +L
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQQL 1952
Query: 2149 --QRELERLQAALRQTEAREIEWREKA 2173
Q+E+ERL++A QTE R +E RE+A
Sbjct: 1953 ELQQEVERLRSAQAQTE-RTLEARERA 1978
Score = 287 bits (734), Expect = 1e-76
Identities = 483/2039 (23%), Positives = 882/2039 (43%), Gaps = 252/2039 (12%)
Query: 527 MLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
M +GL Q L+ L T+ + LESS +L QE+ LA+ Q I L +
Sbjct: 1 MSLGLARAQEVELT-LETVIQTLESS-----VLCQEKGLGARDLAQDAQ-ITSLPALIRE 53
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
+ T + V L A A LL L+EENQ + + E
Sbjct: 54 IVTRNLSQPESPVLLPATEMA----------SLLSLQEENQLLQQELSRVEDL------- 96
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAE--EAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
LA++ R+ L K + +L++A E G + R + + E++++L E ++
Sbjct: 97 LAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQE----EQ 152
Query: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSS 764
A+ + Q +QE ++++ L + +Q K L +K E+ Q +ER + ++L+
Sbjct: 153 ASYRRKLQAYQEGQQRQAQLVQRLQGK-ILQYKKRCSELEQQLLERSGELEQQRLRDTEH 211
Query: 765 AKELLESSLF---EAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
+++L ES+L E QQ+++ + L Q+ A + + ++R K+ D R +
Sbjct: 212 SQDL-ESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR--KVTNDWTRCR 268
Query: 822 AEQE-RDAAARQLAQA-------EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873
E E R+AA R+ ++ E L +Q + V++++ E++ EL
Sbjct: 269 KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGEL 328
Query: 874 AKALESLEREKMELEMRLKEQQTEMEA-------IQAQREEE---RTQAESALCQMQLET 923
A+ +++ + L L+ ++ EA +QAQ EE+ + E L Q Q+++
Sbjct: 329 ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQS 388
Query: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ-ETTGILQTQLQEA-QRELK 981
+ ++ L + T+ LA + + L +D + L E+ E L+ Q Q A + E
Sbjct: 389 DLDKADLSARV--TELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDG 446
Query: 982 EAARQHRDDLA-ALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040
E +Q DLA A+ +S S +Q + ++ D + + QR +
Sbjct: 447 EGLQQTLRDLAQAVLSDSESGVQ--LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
Query: 1041 QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS---IRQQELSALRQDMQEAQGEQK 1097
+ R + ++L L +R L +Q+ Q L LR+ + +++ E++
Sbjct: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
Query: 1098 ELSAQMELLRQ---------EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAK 1148
L Q++ LR E ++E L +LL E S++ A A+E +
Sbjct: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR-EKSNLAHSLQVAQQQAEELR 623
Query: 1149 AAQLQLRLRSTE--SQLEALAAEQQPGNQ--AQAQAQLASLYSALQQALGSVCESRPELS 1204
+ +L+ E Q + L EQ+ Q A+ + +L + L+Q G EL
Sbjct: 624 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL- 682
Query: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRD 1264
+E + +R+ +R +L A AE VA AL K + + + LR
Sbjct: 683 -----------VEVREALSRATLQRD-MLQAEKAE-VAEALTKAEAGRVELELSMTKLRA 729
Query: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324
+ L++ L+ A + + DL R ++Q +EEKS +G+Q E E E
Sbjct: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER 789
Query: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQV---EHLQAAVVEARAQASAA-GILEED 1380
L+ E+ R +G + + A+E L Q+ H ++ + E AQ S E++
Sbjct: 790 LEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 1381 LRTARSALKLKNEEVE-SERERAQALQEQGELKVA------QGKALQENLALLTQTLAER 1433
L AR + + E +E + RE+ +E L V +G+ L E L
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 1434 EEEVETLRGQIQELEKQREMQKA-------ALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
E + ++ Q+ +LE +RE +A A E L+ +L Q++ QE+ L+K
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS-LDK-E 967
Query: 1487 SVLEHLPMAVQEREQKLTVQR----EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
+ + L A +E + L QR E ++ L++++E LE + +L+ + Q + +
Sbjct: 968 LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL 1027
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKM----ECQQKL-IKELEGQRETQRVALTH---LT 1594
+ +K+ ++ E AL+ E + + E QQ L +KE E ++++ T T
Sbjct: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
Query: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERD-------------QEVKSQREQIEE 1641
+ LE Q+ AQS Q D STV A + RD QEV+ +EQ +
Sbjct: 1088 ISLEMERQKRDAQSRQEQD---RSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144
Query: 1642 LQRQKEHLTQDLERRDQELMLQKE-----RIQVLEDQRT-RQTKILEEDLEQIKLSLRER 1695
L +Q++ ++ E +L L ++ R ++LE QR R+++ E Q LR
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS 1204
Query: 1696 GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH----------- 1744
E +R+ ++ EE + K +KL DKE+++ +E
Sbjct: 1205 LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGEL 1264
Query: 1745 ---IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL---QEAREQGELKE 1798
+ E++ + + ++LQ L R++ ++ +E+ LQ +L + A ++ +
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
Query: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER- 1857
L+ +L + + +L QEL+ Q++ Q+ +G E R +E+ L G+LE+A T K++
Sbjct: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG-EFRTRERR--LLGSLEEARGTEKQQL 1381
Query: 1858 -HGELQDHKEQARRLEE-----ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC- 1910
H + K +A R E L+ R Q LE L + + R E L L+
Sbjct: 1382 DHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
Query: 1911 -------AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH--------- 1954
A V +D+ + LE S
Sbjct: 1442 RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD 1501
Query: 1955 -QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
EA R AL+E L + +A + +++ + + L+R L A ++A D+ + +R
Sbjct: 1502 LDPEAVRG---ALREFLQELRSAQRERDELRTQTSALNRQL----AEMEAERDSATSRAR 1554
Query: 2014 QLEEALRIQEGEIQDQDLRY---QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
QL++A+ E + D R Q ++ ++++ + + E R ++ LE+SL
Sbjct: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
Query: 2071 ENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
E +++ + E ++ G + ++E+ L ++ LEL+ L+
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEV-LDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 2131 TSPMEEQSL--KLDSLEPR----------LQRELERLQAALRQTEAREIEWREKAQDLAL 2178
+ Q+L ++DSL+ + LQ +ERL AL + E E R+K + L
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSP-------- 2230
+LAQ+ AS++S ++ + LQ ++ + ++Q LQ+ L+ R+AL + R S
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793
Query: 2231 --GATSTAELGSRGEQG--VQLGEVSGVEAEPSPDGM--------EKQSWRQRLEHLQQA 2278
G + EL +G QL EV E + E++ ++RL LQ+A
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853
Query: 2279 VARL-----EIDRS--RLQRHNVQLRSTLEQVERERRKLKREAMR-AAQAGSLEISKATA 2330
+A+L E++RS RL++ V LR TL++VERE+ + + +R +A+ G L+ + A
Sbjct: 1854 LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913
Query: 2331 SSPTQQDGRGQKNSDAKCV------AELQKEVVLLQAQLTLERKQKQDYITRSAQTSRE 2383
+ R + +A+ V + Q EV Q QL L+++ ++ RSAQ E
Sbjct: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVER---LRSAQAQTE 1969
Score = 209 bits (531), Expect = 3e-53
Identities = 380/1643 (23%), Positives = 662/1643 (40%), Gaps = 249/1643 (15%)
Query: 931 LETLLQTQKELADASQQ---LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
LET++QT + ++ L QD ++ L + + Q L A
Sbjct: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMA 74
Query: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
L +LQEE+ L Q+ +VEDL +Q A+ D + +YN +
Sbjct: 75 --SLLSLQEENQLLQQEL----SRVEDLLAQSRAERDELAI-------------KYNAVS 115
Query: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQ--QELSALRQDMQEAQGEQKELSAQMEL 1105
+ LE+ L +E R LV Q + RQ +E ++ R+ +Q Q Q+ + ++
Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR 175
Query: 1106 LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES---- 1161
L+ ++ + + E QLLE + + +Q+LR + +Q+ ++A ++L S
Sbjct: 176 LQGKILQYKKRCSELEQQLLER--SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLA 233
Query: 1162 QLEALAAEQ--QPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD 1219
Q+ A+ EQ Q G+ QA L +++ R EL + + W E +
Sbjct: 234 QVNAMLREQLDQAGSANQA------LSEDIRKVTNDWTRCRKEL----EHREAAWRREEE 283
Query: 1220 QNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER-LTDTEA 1278
S A S H LW+ L +V+ ER L
Sbjct: 284 -----------------SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGG 326
Query: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
E ++ +Q+ LS ++ E+ L + A L+ +LR L+ +
Sbjct: 327 ELARTSRAVQEAGLGLSTGLRLA------ESRAEAALEKQALLQAQLEEQLRDKVLREKD 380
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
++ K +L+A+V L AV Q + +DL K E +ES
Sbjct: 381 LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE-------KLEALESL 433
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQT----------LAEREEEVETLRGQIQELE 1448
R LQEQ L+ G+ LQ+ L L Q L+ E + G ++ L
Sbjct: 434 R-----LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLS 488
Query: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
QR R + L S L + VQ+ + ++
Sbjct: 489 GQRTPSPPRRSSPGRGRSPRRGPSPACSDS-STLALIHSALHKRQLQVQDMRGRYEASQD 547
Query: 1509 QIRELEK---DRETQRNVLEHQLLEL-EKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
+ L K D E++R LE QL L +K D +++ +++++ E L+ E
Sbjct: 548 LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN 607
Query: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLD---LEERSQ-----------ELQAQSSQ 1610
H ++ Q+ +EL +RE + A L LEE + EL+ Q
Sbjct: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ-----ELMLQKE 1665
+ LE +VLA+EL E + + Q + LQ +K + + L + + EL + K
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL 727
Query: 1666 RIQV--LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
R + L+D ++ + L E L Q KL L +L ++ +Q R + + + R
Sbjct: 728 RAEEASLQDSLSKLSA-LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE 786
Query: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
E ++ + ++E + + + ++ ++ LEQQL L + + L+Q +++
Sbjct: 787 QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR 846
Query: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ----ELEALQQEQQQAQGQEERVKEK 1839
+Q+L++AR + + + ++L+ E + ALA+ +L A ++E + + R++ +
Sbjct: 847 EQELEQARREAQRQVEALERAAREKE-ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
Query: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
+AL+G+L + L + +ARR E+L EG+ + +E L A R+Q
Sbjct: 906 KEALEGSLFEVQRQLAQL---------EARR--EQLEAEGQALLLAKETLTGELAGLRQQ 954
Query: 1900 ----------EKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERD-QELEALRA 1947
+K L+A + AE +AQ E RA + LQ KE +ELEA RA
Sbjct: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
Query: 1948 ESQSS-RHQEEAARARAEALQEALGKAHAALQGKEQH--LLEQAELSRSLEA-------- 1996
+ QS + ++E AR EA +E L + AALQ + LL ++E ++L
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
Query: 1997 -----------STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ---------ED 2036
+T +L+ A SRQ ++ + + +DLR Q ++
Sbjct: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE 1134
Query: 2037 VQQLQQALA----QRDEELRHQQE---------------REQLLEKSLAQRV-QENMIQE 2076
V++LQ+ QRD LR +E R +LLE R QE +
Sbjct: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194
Query: 2077 KQNLGQER--------EEEEIRGLHQSVRE-----------LQLTLAQKEQEILELRETQ 2117
+Q G+ R E E +R ++ +R L+L KEQ++ L E +
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
Query: 2118 Q---------RNNLEALPHSHKTSPMEEQSLK-----LDSLEPRLQRELERLQAALRQTE 2163
R L+ + S + E Q L+ LDS RL REL LQ L E
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGE 1314
Query: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE----QQRLQDELELTR 2219
E E R + L L + +AS+ +++ Q + E++ E ++RL LE R
Sbjct: 1315 RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
Query: 2220 RALEKERLHSPGATSTAEL--GSRGEQGVQL----GEVSGVEAEPSPDGMEKQSWRQRLE 2273
+++ H+ G E E G++L G G+EAE + +++++ +L
Sbjct: 1375 GTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLG 1434
Query: 2274 HLQQAVAR-LEIDR--SRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATA 2330
L+ A+ R L + R S R + E L + GS S A
Sbjct: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
Query: 2331 SSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHS 2390
+SP D D + V +E + +L ++++ + T+++ +R+LA +
Sbjct: 1495 TSPASPD------LDPEAVRGALREFL---QELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 2391 LSHSLLAVAQAPEATVLEAETRR 2413
+ Q +A E RR
Sbjct: 1546 RDSATSRARQLQKAVAESEEARR 1568
Score = 110 bits (275), Expect = 2e-23
Identities = 212/928 (22%), Positives = 369/928 (39%), Gaps = 106/928 (11%)
Query: 14 QSLQLVLEEQVLALQQQMA--ENQAASWRKLKNS--QEAQQRQATLVRKLQAKVLQYRSW 69
+ L+ EE A Q++ + QA K ++S +EA++ + T +R L+ R
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELR-TQLRLLEDARDGLRRE 1176
Query: 70 CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD- 128
E +++L + Q V+ EL L E + E+L N +LR ++KA+
Sbjct: 1177 LLEAQRKLRES-----QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAES 1231
Query: 129 --VVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVT 186
+ K ED E+ AR + ++ E G + E RL + RE+
Sbjct: 1232 ERISLKLANEDKEQKLALLEEARTAVGKEAG------ELRTGLQEVERSRLEAR-RELQE 1284
Query: 187 FRRHFLEMKSATDR---DLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREP 243
RR + S R +L EL+ + L R T+G + R G ++
Sbjct: 1285 LRRQMKMLDSENTRLGRELAELQGR-LALGERAEKESRRETLGLRQRLLKGEASLEVMRQ 1343
Query: 244 AQLLLLLAKTQELEKEAHERSQELI-QLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY 302
+L + K QE E E R + L+ L+ EK +L D L L ++ + +
Sbjct: 1344 -ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL-DHARGLELKLEAARAEAAEL 1401
Query: 303 EKMIKALRETVEILETN----HTELMEHEASLS--RNAQEEKLSLQQVIKDITQVMVEEG 356
+ A + LE + EA L R+A L L + + +
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Query: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD-LRQQLAGCQEA 415
A G L S++ Q + +AV+ LR+ L + A
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
Query: 416 VNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Q++ D+ + AL ++L ++ ERD+ + LQ V + R + +
Sbjct: 1522 ----QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Query: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA-- 533
+ +L + E+ R R Q + + + + EL + + +++ LE
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 534 ---KQSESLSELITLREALESSHLEGELLRQE-------------------------QTE 565
K+ SE T++ L+ LEGEL R +E
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
Query: 566 VTAA-----LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
V A + R ++A++ SE L+ +V L A + SA + + L + L
Sbjct: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
Query: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE----EAGA 676
E + Q + R++AA QA L+EA K+ +L E+ L ++ E EA
Sbjct: 1758 ACEHDRQVLQERLDAARQA-------LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEG 1810
Query: 677 ELQADLRDIQEEKEE--------IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
+LQ LR++ +++E +QK E R QE + L Q + EV A+
Sbjct: 1811 QLQ-QLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
Query: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
+ L +++ AL L VER++ E LS+ K L+ +L A+ + + +
Sbjct: 1870 R----LEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925
Query: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
QLE Q+ + Q+ Q LE+D ++ Q E +++ + AQA+ E LE ++
Sbjct: 1926 QLEAQVVVLEQSHSPAQ-------LEVDAQQQQLELQQEVERLRSAQAQTE--RTLEARE 1976
Query: 849 AAHEKEVNQLREKWEKERSWHQQELAKA 876
AH + V L E+ + QQEL ++
Sbjct: 1977 RAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 322 bits (826), Expect = 2e-87
Identities = 444/1975 (22%), Positives = 863/1975 (43%), Gaps = 231/1975 (11%)
Query: 237 RMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQ 296
R DG+E LL + +E ++ R ++L + Q +K + Q+R EL+ QS+
Sbjct: 102 RCDGKES---LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER--ELAEGEEQSE 156
Query: 297 KQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEG 356
KQ E E+ + R+ E L E E E R A+EE+L
Sbjct: 157 KQ-ERLEQRDRQRRD--EELWRQRQEWQERE---ERRAEEEQLQ---------------- 194
Query: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
GHE ++ D ++ R +L RR+ ++ +QQ Q+ V
Sbjct: 195 ----SCKGHETE-----------EFPDEEQLRR--RELLELRRKGREEKQQQRRERQDRV 237
Query: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR 476
+++ +W + LR+ +KL E Q + + +E +L + R+ELR
Sbjct: 238 -FQEEEEKEWRKRETVLRKEEEKLQEEEP---------QRQRELQEEEEQLRKLERQELR 287
Query: 477 QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS 536
++ + EQ+ RLRR + Q + + Q+EE++E+ ++ ER ++ L + ++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 537 ESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS--SENTLKTEVADL 594
E LR E E +L R+++ E R EQ + E L+ E
Sbjct: 348 EQ-----QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 595 RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654
R ++ + L ++ +Q L+ E+E + + EQ R ++ + E+R
Sbjct: 403 REQQLRRE---QQLRREQQLRREQQLRREQEEER---HEQKHEQERREQRLKREQEERRD 456
Query: 655 EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLH 714
E+ T Q ++ ++ + + + R+ + EE +++ + R +Q+ Q E+
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 715 QEAKRQEEV--LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Q KRQEE L + ++ ++ L RE+ E R Q ++R+ + EQ E E
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQE--ERREQLLKREEEKRLEQ--------ERREQR 566
Query: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
L + +Q+ ++ K + E + Q + + +E + + LK E + ER + E+ R+ ++
Sbjct: 567 L-KREQEERRDQLLKREEERRQQRLKREQE--ERLEQRLKRE-EVERLEQEERREQRLKR 622
Query: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
+ E+E + L + + E+ QLR + ++ R +Q L + E E+ LE RLK
Sbjct: 623 -EEPEEERRQQLLKSEEQEERRQQQLRREQQERR---EQRLKR-----EEEEERLEQRLK 673
Query: 893 EQQTEMEAIQAQREEERTQAESAL------CQMQLETEKERVSLLETLLQTQKELADASQ 946
+ E Q EEE+ QA + Q QLE+E + Q++ Q
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA-------RQSKVYSRPRKQ 726
Query: 947 QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ-EESSSLLQDK 1005
+ +R RQ+ Q+ K + LQ Q +E ++ Q RD Q EE S + +
Sbjct: 727 EGQRRRQE---QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 1006 MDLQKQV-EDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
+ + + E + QL A++ QR EQ + E ++ R ++E E+E L +E+
Sbjct: 784 LSARPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKE-----LQFLEE 836
Query: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
E++L + A ++++E L++D + + +++ + +E +++ L + L
Sbjct: 837 EEQLQRRERAQQLQEEE-DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 1125 LEEL--EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL----EALAAEQQPGNQAQA 1178
E+L E + E++ +E + Q Q R E QL E L E++ + Q
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
+ + LQQ + PE + + ++ L
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPE--------------KRRRQEREKKYREEEELQQEEE 1001
Query: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV------HTELQDLQR 1292
+ + K + W+ Q + +D++Q+ EE+L E EK ++ + E ++LQ+
Sbjct: 1002 QLLREEREKRRRQEWERQYRK---KDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 1293 Q----LSQNQEEKSKWE-GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
+ L + +E + + E +Q E EL + E + + RR + + + + E EL Q
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407
++ L + E + +E + + EE+++ L + E +E + +E
Sbjct: 1119 EEEQLLREEREKRRRQELERQYRE------EEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 1408 QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK- 1466
+ EL+ QE LL + +R +E E + +EL++Q+ Q+ E DLK
Sbjct: 1173 EEELQ-------QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Query: 1467 -----KRNQEVD-------LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
K N D + EQ ++LE + + Q+ + L Q+E+ RE E
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL---RDRQSQQDLQHLLGEQQERDREQE 1282
Query: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574
+ R QR+ + +LE+++Q +R + +KQL L E EE + E +K
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL-----LREEREEKRRRQETDRK 1337
Query: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
+E + +E + L D + R +EL+ Q LE + QER+++
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL---RRQERERKFLK 1394
Query: 1635 QREQIEELQRQKEHLTQDLER--RDQELML---QKERIQVLEDQRTRQTKILEEDLEQIK 1689
+ +Q+ Q +++ L QD +R R++E L +++R E+Q+ R+ + + LE+ +
Sbjct: 1395 EEQQLR-CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
+ER R+ + QL+QER E+ + R LE + LR +E++ + +++ + +
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ-LRRQERDRKFREQELRSQE 1512
Query: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
+ LE++ Q LHR+ + L +++ QQ ++ R++ +E+ L+ + +E Q
Sbjct: 1513 PERKFLEEEQQ-LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK-ERHGELQDHKEQA 1868
+ +RD++ E+Q+ + QE+ K D Q ++ L+ ER + ++ ++
Sbjct: 1572 LSRQERDRKFRL---EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628
Query: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQE-----KALLALQQQCAEQAQEHEVETRA 1923
+ EE+ R + E LR + REQ+ ++Q ++ +E ++ +
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Query: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
+ + + L+ +++E + L+ E Q R + E E L++ + Q + +
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748
Query: 1984 LLEQAELSRSLEASTATLQAS----LDACQAHSRQLEEALRIQEGEI---QDQDLRYQED 2036
+LE+ +L E Q + Q + E+ LR QE + +++ LR + +
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808
Query: 2037 VQQL--------------QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ 2082
QQL Q L ++++ LR +++R+ E+ A QE +E+Q L Q
Sbjct: 1809 EQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA--TQEKSRREEQELWQ 1866
Query: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQ 2137
E E++ + + +RE + QKE++ R+ + + E H P Q
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQ--RHRQVGEIKSQEGKGHGRLLEPGTHQ 1919
Score = 305 bits (780), Expect = 5e-82
Identities = 449/1943 (23%), Positives = 828/1943 (42%), Gaps = 288/1943 (14%)
Query: 456 GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
G+ L +E+ +E L Q QE + R + QL+ + Q +++++QE+
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRR---QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-- 144
Query: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
ER E + E SE E + + EL RQ Q RAE+
Sbjct: 145 ------ER--------ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190
Query: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
+L S + E D + E L L + G ++ Q E V E
Sbjct: 191 E--QLQSCKGHETEEFPDEEQLRRR-----ELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQA-DLRDIQEEKEEIQK 694
E + + K E L E+ + +LQ+ EE +L+ +LR ++E+E+ Q+
Sbjct: 244 KEWRKRETVL-----RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 695 KLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQD 754
+L R +Q QL + +E +R+++ R QE+ E+ ++R + ER Q
Sbjct: 299 RL---RREQ-----QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 755 LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE 814
L + + +E E L Q++ + + + +++ + + ++ ++ E + L+ E
Sbjct: 351 LRREQE-----EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ-LRRE 404
Query: 815 LDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874
R Q + R+ R+ Q +E + +QK E+ +L+ + E+ R W ++E
Sbjct: 405 QQLRREQ-QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 875 KALESLEREKMELEMRLKEQQTE--MEAIQAQREEERTQAESALCQMQLETEKERVSLLE 932
ER K +L+ +E++ E ++ + +R E++ + E L + Q E ++R+ E
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE--LKEAARQHRDD 990
+ Q+ L + QQL R +++ + Q LK +E + +L++ +RE LK + RD
Sbjct: 524 EEERLQQRLR-SEQQLRREQEERREQLLKREE-----EKRLEQERREQRLKREQEERRDQ 577
Query: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
L K+ E+ + Q + ++ +RL ++ +E++ ++ R ++ L
Sbjct: 578 LL-----------------KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 1051 EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQME--LLRQ 1108
+RE+ E+ Q+LL +E + RQQ+L +Q+ +E + +++E ++E L R+
Sbjct: 621 KREEPE-----EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 1109 EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA 1168
+E+ LA+E E+ +A + ++ W E++A Q ++ S + E
Sbjct: 676 HEEERREQELAEE----EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 1169 EQQPGNQAQAQAQLASLYSALQ-QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227
Q+ + + + S LQ Q + E D E + G + L
Sbjct: 732 RQEQEEKRRRRE------SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 1228 KRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTEL 1287
R PL + A + Q ++ ++ R Q ++ E+ L E E+ E
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER 845
Query: 1288 ------------QDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM---ASLQSRLRRA 1332
+D +R+ SQ Q KW + LE E T+ +LQ +LR+
Sbjct: 846 AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ---LEEERKRRRHTLYAKPALQEQLRKE 902
Query: 1333 ---------ELQRMEAQG----ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379
ELQR E + E+E +E L + E L E R + +
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 1380 DLRTARSALKLKNEEVESER--ERAQALQEQGELKVAQGKALQENLALLTQTLAERE--- 1434
D + + +L EE E R ER + +E+ EL+ + + L+E + ER+
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 1435 ------EEVETLRGQ-----IQELEKQ----REMQKAALELLSLDLKKRNQ--------- 1470
EE + LR + +QE E+Q E+Q+ +LL + + R +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 1471 EVDLQQEQIQEL----------EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR--- 1517
E +LQQE+ Q L E+ R E + QE EQ L +RE+ R E +R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQ-QEEEQLLREEREKRRRQELERQYR 1141
Query: 1518 -ETQRNVLEHQLLELE---KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ 1573
E + E QLL E ++ Q +E Q + ++L+++ L L E E+ + E Q
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL--LREEQEKRRQERERQY 1199
Query: 1574 KLIKELEGQRETQRVALTHLTLDLE---------------------ERSQELQAQSSQIH 1612
+ +EL+ Q+ QR DL+ E Q Q + SQ+
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 1613 DLESHSTV--LARELQERDQEVKSQREQI--------EELQR--QKEHLTQDLERRDQEL 1660
D +S + L E QERD+E + +R Q E+L+R QKE +D + ++++
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 1661 MLQKERIQVLEDQRT----RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
+L++ER + Q T R+ + L ++ E+ L +ER R+ + QE+ +
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379
Query: 1717 SKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771
+ R K + LR +E+E + +Q+ + +E + QL +Q + + E +
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 1772 LLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
+RE++ + +QQL++ R + +E+ L + +E Q +RD++ +E+QQ +
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF---LEEEQQLRR 1496
Query: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD 1891
QE K + L+ ++ E +L + Q + L+EE + RR + ++ D
Sbjct: 1497 QERDRKFREQELRS--QEPERKFLEEEQQLHRQQRQRKFLQEEQQL--RRQERGQQRRQD 1552
Query: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
+ RE+E+ L+Q+ EQ + R + L+ Q V + ++QE + + E Q
Sbjct: 1553 RDRKFREEEQ----LRQEREEQQLSRQERDRKFR---LEEQKV-RRQEQERKFMEDEQQL 1604
Query: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
R QE + R E ++ + +EQ L Q + LE + + H
Sbjct: 1605 -RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 2012 SRQL---EEALRIQEGEIQ-----DQDLRYQEDVQQL-----QQALAQRDEELRHQQ--- 2055
R EE +QEGE Q ++D +++E+ QQL ++ Q +++LR Q+
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER 1723
Query: 2056 ---EREQLLEKS----LAQRVQENMIQEKQNLGQEREEEEIRG------------LHQSV 2096
E EQL +++ L ++ + I E++ L EREE+++R L Q
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Query: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM--EEQSLKLDSLEPRLQRELER 2154
E QL + +++ E + +Q + L + EE+ L+L+ E RL++E +R
Sbjct: 1784 EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR 1843
Query: 2155 LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDE 2214
A Q +E RE+ + Q +R E++R E
Sbjct: 1844 QYRAEEQFATQEKSRREEQE---------------------LWQEEEQKRRQERERKLRE 1882
Query: 2215 LELTRRALEKERLHSPGATSTAE 2237
+ R+ E++R G + E
Sbjct: 1883 EHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 295 bits (755), Expect = 4e-79
Identities = 444/1869 (23%), Positives = 807/1869 (43%), Gaps = 265/1869 (14%)
Query: 618 QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Q L+EE ++ C E+ Q R + D E R L E+ + + QK +E E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQ-EEDQRRFEPRDRQLEEEPG--QRRRQKRQEQERE 147
Query: 678 LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA---- 733
L + Q EK+E ++ R +E + E +E +R EE ++ + E
Sbjct: 148 LAEG--EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205
Query: 734 ---LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
+R + LE+R + E +Q E+ + +F+ +++ +
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRER-----------QDRVFQEEEEK--------EW 246
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
+ + + +E +Q E + +R + QE + R+L + E + E+Q+
Sbjct: 247 RKRETVLRKEEEKLQEE--------EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
+ QLR K E+ER Q+E + E E+++ E +L+ +Q E Q +RE+E
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER---------LRQDMKVQKLK 961
+ E L + Q E +E+ E L+ +++L QQL R LR++ ++++ +
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQ 417
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+ L+ + +E + E K + L QEE L+ + + ++ ++ + Q +
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 1022 QDD-----------------------------------SQRLVEQE----VQEKLRETQE 1042
+D QRL QE +Q++LR Q+
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 1043 YNRIQKE-------------LEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089
R Q+E LE+E+ L ++E+R +L+ + RQQ L +++
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 1090 --QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL-------RA 1140
Q + E+ E Q E Q +K +E + + QLL+ E +QQL R
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200
+E + +L+ RL+ E + E E Q QA+ ++ S Q L S ++R
Sbjct: 657 QRLKREEEEERLEQRLK-REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD 1260
V+ Q G R ++ +E + H+ + +Q RD
Sbjct: 716 QS---------KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 1261 V-----LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ-----NQEEKSKWEGKQNS 1310
++ ++ +RL+ + Q +L+ +RQ + +EEK + ++
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE--------HLQA 1362
E EL L E LQ R R +LQ E + LQ +E +Q + L+
Sbjct: 827 REKELQFLEEE-EQLQRRERAQQLQE-----EEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 1363 AVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN 1422
R A L+E LR + L+ + EE++ E + QEQ + + QE
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 1423 LALLTQ------------------TLAEREEEV---ETLRGQIQELEK----QREMQKAA 1457
LL + L ++EE++ E + + QE EK + E+Q+
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 1458 LELLSLDL-KKRNQEVDLQQEQIQELEKCRSVL---EHLPMAVQEREQKL----TVQREQ 1509
+LL + K+R QE + Q + EL++ L E +QERE++ +Q+E+
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 1510 IRELEKDRET-QRNVLEHQLL---ELEKKDQMI---ESQRGQVQDLKKQLVTLECLALEL 1562
+ L ++RET +R LE Q EL+++++ + E ++ + Q+ ++Q E L E
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE- 1119
Query: 1563 EENHHKMECQQKLIKELEGQ-RETQRVALTHLTLDLEE----RSQELQAQSSQIHDLESH 1617
EE + E +++ +ELE Q RE + V L EE R QEL+ Q + +L+
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 1618 STVLARELQE-RDQEVKSQREQIEELQRQ--KEHLTQDLERRDQELMLQKERIQVLEDQR 1674
L RE QE R QE + Q + EELQRQ K+ + +R D + + E+ + D +
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 1675 TRQTKILEEDLEQIKLS-LRERGRELTTQRQL--MQERAEEGKGPSKAQRG-SLEHMKLI 1730
E Q++ S LR+R + Q L QER E + QR + +
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 1731 LRDKEKEVECQ-QEHIHELQELKDQLEQ--QLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787
R+++KE + + ++ E Q L+++ E+ + Q RK E LL +RE++ + Q++
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ-QAQGQEERVKEKADALQGA 1846
++ RE+ EL+ Q + E ++ L ++++E + L++EQQ + Q +E+++++ D +
Sbjct: 1360 RKFREE-ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR-KFR 1417
Query: 1847 LEQAHMTLKERHGELQDHKEQARRLEEE---------LAVEGRRVQALEEVLGDLRAES- 1896
E+ ++ +ER + ++ ++Q RR E E L E R EE L R E
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 1897 ---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
+E+++ L +QQ Q ++ + + L+ + + E +Q+L R + Q
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFLEEEQQLH--RQQRQRKF 1533
Query: 1954 HQEEAARARAEALQEALGKAHAALQGKEQ--HLLEQAELSRSLEASTATLQASLDACQAH 2011
QEE R E Q+ + +EQ E+ +LSR L+ Q
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 2012 SRQL---EEALRIQEGE---IQDQDLRYQEDVQQLQQALAQRDEELRHQQERE-QLLEKS 2064
R+ E+ LR QEG+ Q++D +++ED Q LQ +R+E+ H+QER+ + LE+
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ----EREEQQLHRQERDRKFLEEE 1649
Query: 2065 LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEA 2124
R QE Q + + ++ EEE L Q E QL +++++ E + +R E
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEE--QLLQEGEEQQLRRQERDRKFREEEQQLRRQERE- 1706
Query: 2125 LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184
+ EEQ L+ LE + + E + Q ++ R+ +R+ ++ L + +
Sbjct: 1707 -----RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Query: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQ 2244
+ + F + L ++ E+Q+L+ + E R+ E+E+L R EQ
Sbjct: 1762 QQLRRQERDRKFREEEQLRQEREEQQLRSQ-ESDRKFREEEQLRQ----------EREEQ 1810
Query: 2245 GVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE 2304
++ + G K W + L++ RL +R R R Q +T E+
Sbjct: 1811 QLRPQQRDG-----------KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF-ATQEKSR 1858
Query: 2305 RERRKLKRE 2313
RE ++L +E
Sbjct: 1859 REEQELWQE 1867
Score = 290 bits (742), Expect = 1e-77
Identities = 437/1968 (22%), Positives = 841/1968 (42%), Gaps = 250/1968 (12%)
Query: 102 RLEEEQQRCESL--------AEVNTQLRLHMEKADVVNKALREDVEKLTV-DWSRARDEL 152
R EE+Q+R E + Q R E+ + E E+L D R +EL
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173
Query: 153 MRKESQWQMEQE---------FFKGYLKGEHGRLLSLWR-EVVTFRRHFLEMKSATDRDL 202
R+ +WQ +E KG+ E L R E++ RR E K R+
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233
Query: 203 ME--LKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEA 260
+ + E + T + Q EP + E QL L + QEL +E
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKL--ERQELRRER 290
Query: 261 HERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNH 320
E Q+ +L+ + L + + ++R + Q +++ + E+ + LR E
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE------ 344
Query: 321 TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
E R QEE+ QQ+ ++ + E+ Q E L + + +
Sbjct: 345 ----ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE-- 398
Query: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
Q + L R RR Q ++ R+Q ++ +Q+H+Q E + R++ ++
Sbjct: 399 -QQLRREQQLRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEER- 454
Query: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
RD L + + E + ++++L + EE R++ LE+E R ++ E QL+
Sbjct: 455 ---RDWLKREEETERHEQER--RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 501 DSAQGQKEEQQEELHLAVRERERLQEMLMG---LEAKQSESLSELITLREA--LESSHLE 555
+ +EE++E+ E ERLQ+ L L +Q E +L+ E LE E
Sbjct: 510 E-----QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE 564
Query: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGL 615
L R+++ L R E+ + LK E + +K E L++
Sbjct: 565 QRLKREQEERRDQLLKREEER------RQQRLKREQEERLEQRLKRE---EVERLEQEER 615
Query: 616 NQQLLQLEE----ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
+Q L+ EE Q + E E+ + L+ + E ++R E+ LE +L++
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 672 EEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEA-ATTQLEQLHQEAKRQEEVLARAVQ 729
E Q + QE+ +E I+ ++ + + Q E+ A + +++ ++QE R Q
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 730 EKEALVREKAALEVRLQAVER-DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
E++ RE E++ Q ER RQ E+ + + + E +Q+ S +
Sbjct: 736 EEKRRRRES---ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA------------EQERDAAARQLAQA 836
Q E Q++ A+E Q E R L E + E+ + E+E R+ AQ
Sbjct: 793 QRERQLR----AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 837 EQEGKTALEQQKAAHEKEVNQLREKW------EKERSWH--------QQELAKALESLER 882
QE + L++ + + + +KW E++R H Q++L K + L+
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 883 EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELA 942
E+ EL+ +E++ E + REEE+ Q E ++ E EK R E + K+L
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQL-LREEREKRRRQERERQYRKDKKLQ 967
Query: 943 DASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELK---EAARQHRDDLAAL 994
+QL E+ R+ + +K +E+E + QL +RE + E RQ+R L
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK-DEL 1026
Query: 995 QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREK 1054
Q+E LL+++ + ++++++ + Q +++ Q+ EQ + E+ RET+ ++++ +E+
Sbjct: 1027 QQEEEQLLREERE-KRRLQERERQYREEEELQQEEEQLLGEE-RETRRRQELERQYRKEE 1084
Query: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
+++E+ L+ +E + R+QE ++ +E Q E+++L LR+E +++
Sbjct: 1085 E------LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL------LREEREKRR 1132
Query: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES---QLEALAAEQQ 1171
L E Q EE E EQ LR ++ + +L+ + R E + E L E+Q
Sbjct: 1133 RQEL--ERQYREEEEVQQEEEQLLREE--PEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 1172 PGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA---RSLFK 1228
+ + + Q +Q + + + W EP++ A ++
Sbjct: 1189 EKRRQERERQYREEEELQRQ------KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 1229 RGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ 1288
+G +L + +Q++ L+ + + +ER + E + Q
Sbjct: 1243 KG---------RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348
+ QL + +++++K +++ E +L+ + + RR E R + E+ L +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREER-----EEKRRRQETDRKFREEEQLLQER 1348
Query: 1349 AKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALK---LKNEEVESERERAQAL 1405
++ L Q + E R Q LEE+ R R + LK E+ +ER Q L
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL 1465
++ + K + ++ L+ + REEE Q++ E++R+ + +L
Sbjct: 1409 RQDRDRKFREE---EQQLSRQERDRKFREEEQ-----QVRRQERERKFLEEEQQLRQERH 1460
Query: 1466 KK-RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524
+K R +E LQ+ + Q+L + QER++K + +Q+R E+DR+ + L
Sbjct: 1461 RKFREEEQLLQEREEQQLHR------------QERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE--LEGQ 1582
Q E E+K E Q + Q +K L + L + + + +K +E L +
Sbjct: 1509 RSQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Query: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ-REQIEE 1641
RE Q+ L +ER ++ + + ++ E + E Q R QE + Q R++ +
Sbjct: 1567 REEQQ-------LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
R+ E L Q ER +Q+L Q+ + LE++ + + E+ L +R R+
Sbjct: 1620 KFREDEQLLQ--EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH------DRDRKFRE 1671
Query: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK------DQL 1755
+ QL+QE E+ + R E + + R + + Q+E QEL+ +QL
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 1756 EQQL-------QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Q+ Q +RK+ E L +RE++ + Q++ ++ RE+ +L+++ + QL
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
+ R++E ++E+QQ + Q+ K + E+ + L+E+ L+ +++
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYR-------WEEEQLQLEEQEQRLRQERDRQ 1844
Query: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
R EE+ A + +SR +E+ L ++Q Q +E R L++
Sbjct: 1845 YRAEEQFATQ---------------EKSRREEQELWQEEEQKRRQERE-----RKLREEH 1884
Query: 1929 LQAQAVLKERDQELEALRAES--------QSSRHQEEAARARAEALQE 1968
++ Q ++R +++ ++++ + HQ + R+ L E
Sbjct: 1885 IRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYE 1932
Score = 238 bits (608), Expect = 4e-62
Identities = 408/1844 (22%), Positives = 773/1844 (41%), Gaps = 237/1844 (12%)
Query: 28 QQQMAENQAASWRKLKNSQEAQQRQATLVR---KLQAKVLQYRSWCQELEKRLEATGGPI 84
QQQ E Q +++ + +E ++R+ L + KLQ + Q + QE E++L
Sbjct: 227 QQQRRERQDRVFQE-EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 85 PQRWENVEEPNLDELL----VRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEK 140
+R EE L +R ++E++R E E Q ++ + + LR + E+
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 141 LTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDR 200
R E R+E Q + EQE E R L RE R L + R
Sbjct: 346 RREQQLRREQEEERREQQLRREQE--------EERREQQLRREQQLRREQQLRREQQLRR 397
Query: 201 DLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEA 260
+ +L+ E L +L Q R R + + + + Q L++E
Sbjct: 398 E-QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE-----RREQRLKREQ 451
Query: 261 HERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKM-IKALRETVEILETN 319
ER LK + + E+ E + R +L Q +++ E + K+ + RE E E
Sbjct: 452 EERRD---WLKREEETERHEQERRKQQLKR--DQEEERRERWLKLEEEERREQQERREQQ 506
Query: 320 HTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQF 379
E QEE+ LQQ ++ Q+ E+ + Q E L+ Q
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ- 565
Query: 380 DYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQK 439
R ++ ++ R QL +E ++Q E+ + L QRL++
Sbjct: 566 -----------------RLKREQEERRDQLLKREEE----RRQQRLKREQEERLEQRLKR 604
Query: 440 LTGER-DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ----LEVLEQEAWRLRRVNV 494
ER + + L+ E + ++LL+ +E R+Q E E+ RL+R
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Query: 495 ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH- 553
E +L+ + + EE++ E LA E+E+ +E + K L R++ S
Sbjct: 665 EERLE-QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 554 --LEGELLRQEQTEV----TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607
EG+ RQEQ E + L E+ A E + + A K +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 608 LALDKVGLNQQLLQLE-EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEA 666
L+ Q+ QL EE Q R E+ + + E EK + L E E
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE-----EE 838
Query: 667 QLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE-QLHQEAKRQEEVLA 725
QLQ+ E A + +QEE++ +Q+ R Q++ + QL +E KR+ L
Sbjct: 839 QLQRRERA--------QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785
+E L +E+ L+ + ++R+ ++ + + +E E L + ++Q E
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE--EEQLQQEEEQLLREER 948
Query: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ-------AEQERDAAARQLAQAEQ 838
K + + + + + K++ Q E + L E + R Q E+E QL + E+
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 839 EGKTALEQQKAAHEKEVNQ------LREKWEKERSWHQQELAKALESLEREKMEL--EMR 890
E + E ++ +K+ Q LRE+ EK R ++ + E L++E+ +L E R
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLE----TEKERVSLLETLLQTQKELADASQ 946
++ E+E Q ++EEE Q E L + + E E+ER E LQ ++E +
Sbjct: 1069 ETRRRQELER-QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 947 QLERLRQDMKVQKLKEQETTGILQTQLQE--AQRELKEAARQHRDDLAALQEESSSLLQD 1004
+ +R RQ+++ Q +E+E + L+E +R +E RQ+R++ LQ+E LL++
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLLRE 1186
Query: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
+ + ++Q + + + + + L Q+ +++ R+ + + ++ + E EK + +
Sbjct: 1187 EQEKRRQERERQYR-----EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE----NAVRD 1237
Query: 1065 EQRLLVLQEADSIRQQELSALR-----QDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
+ +E + RQ E S LR QD+Q GEQ+E + E R + +++
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR------ 1291
Query: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
H E++ L +E K A+ + R E QL E++ Q +
Sbjct: 1292 ------------HFPEEE---QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ-ETD 1335
Query: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAE 1239
+ LQ+ E +P D L + G + L + L +
Sbjct: 1336 RKFREEEQLLQER-----EEQPLRRQERDRKFREEELRHQEQGRKFLEEE----QRLRRQ 1386
Query: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299
K Q L ++ + + +D+ +K E E Q L RQ +
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFRE--------------EEQQLSRQERDRKF 1432
Query: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359
+ + + ++ E + +E + + + R R E Q ++ + E++L + ++ + E
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419
+ R Q E++LR+ K EE + R++ Q K L
Sbjct: 1493 ------QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR------------KFL 1534
Query: 1420 QENLALLTQTLA-EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
QE L Q +R ++ + + ++L ++RE Q+ L ++R+++ L++++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-------LSRQERDRKFRLEEQK 1587
Query: 1479 IQELEKCRSVLE-HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQM 1537
++ E+ R +E + QE +Q+L +R+ R+ +D + + E QL E+ +
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERD--RKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 1538 IESQ-RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD 1596
+E + + + Q+ ++QL + K +++L++E E Q+ L
Sbjct: 1646 LEEEPQLRRQEREQQL---------RHDRDRKFREEEQLLQEGEEQQ-----------LR 1685
Query: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
+ER ++ + + Q+ E L E Q R R+++E R++E L Q+ E+
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLR-------RQELERKFREEEQLRQETEQ- 1737
Query: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
++L Q+ ++LE+++ R + E+ +L +ER R+ + QL QER E+
Sbjct: 1738 -EQLRRQERYRKILEEEQLRPER------EEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 1717 SKAQRGSLEHMKLILRDKEKEVECQQ--------EHIHELQELKDQLEQQLQGLHRKVGE 1768
++ R E +L +E+++ QQ E +L+E + +L Q+ +R +
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 1769 TSLLLSQREQEIVVLQQQLQEAREQGE--LKEQSLQSQLDEAQR 1810
+ R +E + Q++ Q+ R++ E L+E+ ++ Q E QR
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Score = 211 bits (537), Expect = 7e-54
Identities = 369/1613 (22%), Positives = 660/1613 (40%), Gaps = 193/1613 (11%)
Query: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKR 76
Q + EQ L +QQ+ Q + + E + Q ++L+ + + R W + E+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 77 LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRE 136
Q+ + +E E ++LEEE++R E QLR E+ +E
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERR-EQQERREQQLRREQEERREQRLKRQE 523
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFK-GYLKGEHGRLLSLWREVVTFRRHFLEMK 195
+ E+L + +R E Q + EQE + LK E + L R R L+ +
Sbjct: 524 EEERL--------QQRLRSEQQLRREQEERREQLLKREEEKRLEQER-----REQRLKRE 570
Query: 196 SATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQE 255
RD + LK E R L + +E R+ E +L + Q
Sbjct: 571 QEERRDQL-LKREEERRQQRL----------KREQEERLEQRLKREEVERLEQEERREQR 619
Query: 256 LEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI 315
L++E E + LKS+ E+ + Q R E Q K+ E+ E++ + L+ E
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLR-REQQERREQRLKREEEEERLEQRLKREHE- 677
Query: 316 LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375
E EL E E +R + ++ Q + E D S +
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQ------WQLESEAD------------ARQSKV 719
Query: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD---QWEEEGKA 432
+S+ Q+ + RR +Q ++ A Q+ +Q+ D QW+ E K+
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE--EQRRDFTWQWQAEEKS 777
Query: 433 LRQRLQKLTG--------ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ 484
R R Q+L+ ER A + + +E+E ++ R E ++L+ LE+
Sbjct: 778 ERGR-QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 485 EAWRLRRVNV-ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543
E RR +LQ + D Q +E ++ + E+ R Q+ LE ++ L
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQ------EQRRDQKWRWQLEEERKRRRHTLY 890
Query: 544 TLREALESSHLEGELLRQEQTEV---------TAALARAEQSIAELSSSENTLKTEVADL 594
E E +LL++E+ E+ R + +L E L E +
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 595 RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR----MEAAEQARNALQVDLAEA 650
R + + L + +QLL E E + R E E + Q+ E
Sbjct: 951 RRRQERERQYRKDKKLQQ--KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 651 EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQE------EKEEIQKKLSESRHQQE 704
EKRR WE+ + +LQ+ EE + + R +QE E+EE+Q++ E +E
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE-EEQLLGEE 1067
Query: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSS 764
T + ++L ++ +++EE+ QE+E L+RE+ R + + R++ E+LQ
Sbjct: 1068 RETRRRQELERQYRKEEEL----QQEEEQLLREEPEKRRRQERERQCREE--EELQ--QE 1119
Query: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ 824
++LL + ++Q +LE Q + + +EV Q E + L+ E + R Q E
Sbjct: 1120 EEQLLREEREKRRRQ---------ELERQYR---EEEEVQQEEEQLLREEPEKRRRQ-EL 1166
Query: 825 ERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL----------- 873
ER + Q E+E EQ+K E+E Q RE+ E +R +Q
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERE-RQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Query: 874 ---AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
+ ++ K+ + R EQ ++E Q + + + + L + Q E++R
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ---ERDREQE 1282
Query: 931 LETLLQTQKELADASQQLERLRQ-DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRD 989
Q + + +QLER Q + K + K QE +L+ + +E +R +E R+ R+
Sbjct: 1283 RRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR-QETDRKFRE 1340
Query: 990 DLAALQE-ESSSLLQDKMDLQKQVEDLKSQLVAQ---DDSQRLVEQEVQEKLRETQEYNR 1045
+ LQE E L + + D + + E+L+ Q + ++ QRL QE + K + ++ R
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 1046 IQKELEREKASLTLSLMEKEQRL-------LVLQEADSIRQQEL--------SALRQDMQ 1090
Q+ ++ + E+EQ+L +E +R+QE LRQ+
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
E+++L + E + +E++ FL +E QL + EQ+LR+ E K
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ--EPERKFL 1518
Query: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210
+ + +L + Q + L EQQ Q + Q + ++ + + R E
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQER 1577
Query: 1211 PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRD-QVQKL 1269
+ LE +Q R +R + + K ++ +L++ + Q+L
Sbjct: 1578 DRKFRLE-EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK--QNSLESEL--MELHETMASL 1325
+ D + + + Q+ ++QL +++ K + E + Q E +L E
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Query: 1326 QSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL--QAAVVEARAQASAAGILEED-LR 1382
+ +LRR E +R Q E++L + E + E L + + R Q ILEE+ LR
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 1383 TARSALKLK----------NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
R +L+ E++ ERE Q ++ + K + + L++ +
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 1433 R------EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
R EEE L Q Q L ++R+ Q A E + K R +E +L QE+ Q+
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR--- 1873
Query: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
QERE+KL + E IR +K+ + R V E + E + +++E
Sbjct: 1874 ----------QERERKL--REEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 181 bits (460), Expect = 6e-45
Identities = 334/1530 (21%), Positives = 602/1530 (39%), Gaps = 187/1530 (12%)
Query: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ----ELEKR 76
E+Q QQ E + ++LK +E ++ Q L + Q + Q Q E EKR
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 77 LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL-R 135
LE QR + +E D+LL R EE +Q+ RL E+ + + + L R
Sbjct: 558 LEQERRE--QRLKREQEERRDQLLKREEERRQQ-----------RLKREQEERLEQRLKR 604
Query: 136 EDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK 195
E+VE+L + R L R+E + + Q+ K + E R L RE R L+ +
Sbjct: 605 EEVERLEQE-ERREQRLKREEPEEERRQQLLKSE-EQEERRQQQLRREQQERREQRLKRE 662
Query: 196 SATDRDLMELKAEHV------------------RLSGSLLTCCLRLTVGAQSREPN---- 233
+R LK EH R+ + +L A +R+
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 234 -----GSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKS-----QGDLEKAELQD 283
G R +E + + E+ AH + QE Q + Q + + +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 284 RVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQ 343
R++ L Q ++Q E+ + R E E E EE+ LQ+
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 344 VIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADK-------ALTLVRSVLT 396
++ Q + EE D + + S E ++ ++ K A ++ L
Sbjct: 843 --RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 397 RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
+ +Q +Q+ ++L + Q+Q Q+ EE + ++ Q L ER+ Q + Q
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 457 EVDSL--SKERELL---------QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQG 505
D KE +LL Q+ ++ R++ E+ ++E LR + + Q Q
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Query: 506 QKEE--QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563
+K++ QQEE L ERE+ + + ++ E L + E L GE + +
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ--------EEEQLLGE---ERE 1069
Query: 564 TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
T L R + EL E L E + R + E ++ L Q+ QL
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER-----ERQCREEEELQQEEEQLL 1124
Query: 624 EENQSVCSRMEAAEQARNALQVDLAEAEK-RREALWEKNTHLEAQLQKAEEAGAELQADL 682
E + R E Q R +V E + R E + LE Q ++ EE E + L
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 683 RDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE 742
R+ QE++ Q++ + R ++E + +Q +++ ++ ++ + EKE VR+
Sbjct: 1185 REEQEKRR--QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY- 1241
Query: 743 VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL-EVQIQTVTQAK 801
+ + E+ RQ QL+ S ++L + L E Q+++ E + Q + Q +
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDL-QHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300
Query: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE- 860
Q E + + E+ +ER+ R+ ++ + E+++ E+E LR
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRR----QETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 861 ----KWEKERSWHQQELAKALESLER------------EKMELEMRLKEQQTEMEAIQAQ 904
K+ +E HQ++ K LE +R E+ +L + +EQQ + +
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 905 REEERTQAESALC------QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
REEE+ + + Q+ ++ LE Q ++E ++ E+L Q+ + Q
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK-- 1016
+L QE + Q+ +R+ E R+ R+ QE L+++ L +Q K
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQ--ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 1017 ---SQLVAQDDSQRLVEQEVQEKLRETQEYN--RIQKELEREKASLTLSLMEK-----EQ 1066
QL Q+ Q+ Q+ K RE ++ R +++L R++ L E+ EQ
Sbjct: 1535 QEEQQLRRQERGQQR-RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 1067 RLLVLQEADSIRQQE-LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL 1125
+++ +R+QE LRQ+ E ++L + E + +E++ FL +E QL
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 1126 EELEASHITEQQLRASLWAQEAKAAQL-----QLRLRSTESQLEALAAEQQPGNQAQAQA 1180
+ EQQLR + + QL + +LR E + EQQ Q + +
Sbjct: 1654 RQER-----EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 1181 QLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240
L +Q L +L E +Q + +++ L E
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQE---------TEQEQLRRQERYRKILEEEQLRPER 1759
Query: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE 1300
L + +D ++ + + Q+L + +D + + + + ++ Q+ Q ++
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 1301 KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360
K +WE +Q LE + + RLR+ ER+ A+E Q +
Sbjct: 1820 KYRWEEEQLQLEEQ-----------EQRLRQ----------ERDRQYRAEEQFATQEK-- 1856
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+R + EE R KL+ E + +++ Q ++ GE+K +GK
Sbjct: 1857 ------SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
L T A L IQE Q
Sbjct: 1911 RLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940
Score = 172 bits (435), Expect = 5e-42
Identities = 313/1377 (22%), Positives = 568/1377 (41%), Gaps = 168/1377 (12%)
Query: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWC 70
+K + ++ + +E+ + + E + ++L S+E ++R+ +R+ Q + + R
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 71 QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME-KADV 129
+E E+RLE QR + E E + EE++Q E + + + +E +AD
Sbjct: 662 EEEEERLE-------QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 130 VNKALREDVEKLTVDWSRARDELMRK----ESQWQMEQEFFKGYLKGEHGRLLSLWREVV 185
+ K R E R+ E QWQ E+ + + E R + W+
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT-WQWQA 773
Query: 186 TFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQ 245
+ + + L E + +R R E R RE +
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQ----QREQRFLPEEEEKEQRRRQRREREK 829
Query: 246 LLLLLAKTQELEKEAHERSQELIQ----LKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
L L + ++L++ ER+Q+L + L+ + +++ Q R + L + +K+
Sbjct: 830 ELQFLEEEEQLQR--RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 302 --YEK--MIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGD 357
Y K + + LR+ ++L+ EL E R ++E+ ++ Q+ EE
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER-----QYREEEQLQQEEEQ 942
Query: 358 NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVN 417
+ + E + Q ++ L RR++ + R++ QE
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 418 LLQQQHD-----QWE-----------EEGKALRQRLQKLT--------GERDTLAGQTVD 453
LL+++ + +WE EE + LR+ +K E + L +
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 454 LQGEVDSLSKERELLQKAR--EELRQQLE-VLEQEAWRLRRVNVELQLQGDSAQGQKEEQ 510
L GE + +EL ++ R EEL+Q+ E +L +E + RR E Q + + Q+EEQ
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 511 ----------QEELHLAVRERERLQ---EMLMGLEAKQSESLSELITLREALESSHLEGE 557
++EL RE E +Q E L+ E ++ RE E E +
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 558 LLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRA------AAVKLSALNEALALD 611
LLR+EQ + R + EL + + D R+ K +A+ +
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
K N+Q QLE+ + + Q E E+RR +++ E QL++
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731
E+ A+ + R QEEK+ ++++ E R +QE E+ +R+E+ L R QE+
Sbjct: 1303 EQKEAKRRD--RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR--QER 1358
Query: 732 EALVREKAAL-----------EVRLQAVERDRQDLAEQLQGLSSAKEL-----LESSLFE 775
+ RE+ E RL+ ER+R+ L E+ Q +E + E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR---Q 832
+QQ S E + E + Q Q +E + E Q QER R Q
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERE----------RKFLEEEQQLRQERHRKFREEEQ 1468
Query: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
L Q +E + +++ +E QLR + E++R + +QEL + ER+ +E E +L
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQ-ERDRKFREQELRS--QEPERKFLEEEQQLH 1525
Query: 893 EQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLR 952
QQ + + +Q +++ R + Q +++R E L+ ++E QQL R
Sbjct: 1526 RQQRQRKFLQEEQQLRRQER-----GQQRRQDRDRKFREEEQLRQERE----EQQLSRQE 1576
Query: 953 QDMKV----QKLKEQETTGIL-----QTQLQEAQRELK-EAARQHRDDLAALQEESSSLL 1002
+D K QK++ QE Q + QE Q++L+ E R+ R+D LQE L
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVE------QEVQEKLRETQEYNRIQKELEREKAS 1056
+ +K +E+ + QL Q+ Q+L +E ++ L+E +E ++E +R+
Sbjct: 1637 HRQERDRKFLEE-EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
L +E+ LQE +R+QEL R+ +E Q Q+ + Q +L RQE K
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELE--RKFREEEQLRQE--TEQEQLRRQERYRK--- 1748
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA 1176
+ +E QL E E EQQLR ++ + + QLR E QL + ++++ +
Sbjct: 1749 -ILEEEQLRPERE-----EQQLRRQERDRKFREEE-QLRQEREEQQLRSQESDRKFREEE 1801
Query: 1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL 1236
Q + + QQ G +L LE + R +R A
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQ-----------LEEQEQRLRQ--ERDRQYRAE 1848
Query: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
A + Q+LW+ ++ + +++ +KL E + ++ Q H ++ +++ Q
Sbjct: 1849 EQFATQEKSRREEQELWQEEEQKR-RQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 161 bits (407), Expect = 8e-39
Identities = 232/983 (23%), Positives = 428/983 (43%), Gaps = 121/983 (12%)
Query: 1458 LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMA--VQEREQKLTVQREQIRELEK 1515
LELL LD N VD + + + ++ L A + E ++ +E + + +
Sbjct: 58 LELLDLD---SNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRR 114
Query: 1516 DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575
E QR E +D+ +E + GQ + K+Q E L E + E Q++L
Sbjct: 115 QEEDQRR--------FEPRDRQLEEEPGQRRRQKRQEQERE-----LAEGEEQSEKQERL 161
Query: 1576 IKELEGQRETQRVALTHLTLDLEER-SQELQAQSSQIHDLES---HSTVLARELQERDQE 1631
+ +R+ + + EER ++E Q QS + H+ E + REL E ++
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221
Query: 1632 VKSQREQIEELQRQKEHLTQDLER--RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK 1689
+ +++Q + +RQ ++ E+ R +E +L+KE ++ E++ RQ ++ EE+ + K
Sbjct: 222 GREEKQQ-QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
L +E L +ER EE + Q+ L + + R +E+E QQE E Q
Sbjct: 281 LERQE----------LRRERQEE-----EQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 1750 ELKDQLEQQL-QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
E ++Q E++ Q L R+ E +REQE +QQL+ +E+ E +EQ L+ +
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE-ERREQQLRREQQLR 384
Query: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
+ +R+Q+L QQ +++ Q + E+ + L+ + +ERH + + + +
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 1869 RRL---------------EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913
+RL E E + RR Q L+ E +E+ L +++ EQ
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKR-----DQEEERRERWLKLEEEERREQ 499
Query: 1914 AQEHEVETRALQDSWLQAQAVLKERDQEL-EALRAESQSSRHQEEAARARAEALQEALGK 1972
+ E + R Q+ + + +E ++ L + LR+E Q R QEE R E L + +
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE----RREQLLKREEE 555
Query: 1973 AHAALQGKEQHLLEQAE------LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI 2026
+ +EQ L + E L R E L+ + + EE R+++ E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 2027 QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREE 2086
++Q L+ +E ++ +Q L + +E+ ++ R+Q L + +R ++ + +E++ +ER E
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQ---EERRQQQLRREQQERREQRLKREEE---EERLE 669
Query: 2087 EEIRGLHQSVRELQLTLAQKEQEILELR--------ETQQRNNLEALPHSHKTSP--MEE 2136
+ ++ H+ R Q LA++EQE R + Q + +A + P E
Sbjct: 670 QRLKREHEEERREQ-ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 2137 QSLKLDSLEPRLQRELE----RLQAALRQ----TEAREIEWREKAQDLALSLAQTKASVS 2188
Q + + E R +RE E + A RQ + R+ W+ +A++ + Q ++
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 2189 SLQEVAMFLQASVLERDSEQQRL--QDELELTRRALEKERLHSPGATSTAELGSRGEQGV 2246
L+E Q ER +QR ++E + RR +ER E R E+
Sbjct: 789 PLRE-QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 2247 QL-----GEVSGVEAEPSPDGMEKQSWRQRLE-------HLQQAVARLEIDRSRLQRHNV 2294
QL G E S + Q WR +LE H A L+ + Q+
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSL-----EISKATASSPTQQDGRGQKNSDAKCV 2349
+ L++ ERE+R+ + + + + L ++ + +Q+ Q D K
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL- 966
Query: 2350 AELQKEVVLLQAQLTLERKQKQD 2372
QKE LL + R+Q+++
Sbjct: 967 --QQKEEQLLGEEPEKRRRQERE 987
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 296 bits (758), Expect = 2e-79
Identities = 499/2524 (19%), Positives = 1049/2524 (41%), Gaps = 266/2524 (10%)
Query: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT-LVRKLQAKV----LQYRSWCQ 71
+L EQ + Q + A L+N+ E ++ ++ L+ K++ +V L + + +
Sbjct: 281 ELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE 340
Query: 72 ELEKRLEA------TGGPIPQRWENVEEPNLDELLVRL----------EEEQQRCESLAE 115
E+ LE + R+ +E+ + E+ + +E Q C++L +
Sbjct: 341 EMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD 400
Query: 116 VNTQLRLHMEKADVVNKA-----LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYL 170
N++L L + V A L + +++ + + S+ + L ++ + + F Y
Sbjct: 401 QNSKL-LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN 459
Query: 171 KGEHG----RLLSLWREVVTFRRHFLEMKSA---TDRDLMELKAEHVRLSGSLLTCCLRL 223
+G + SL + VV K A + +L ELKAE+ +LS + +
Sbjct: 460 EGTQAVTEENIASLQKRVVELENE----KGALLLSSIELEELKAENEKLSSQITLLEAQN 515
Query: 224 TVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQD 283
G RE + +D + LE ++ +EL L LE E Q+
Sbjct: 516 RTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL----LEMKEAQE 571
Query: 284 RVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQ 343
+ L L + + D+E + + + ++ +E ++ + L Q+ L +
Sbjct: 572 EIAFLKLQLQGKRAEEADHEVLDQ---KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNE 628
Query: 344 VIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQ 403
+ V E+ Q E D+ + + QD DK+L+ V + + ++
Sbjct: 629 E-SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
Query: 404 DLRQQLAGCQ----EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
L+ Q+ + +A + ++ D+ +E L Q +++ D + L E D
Sbjct: 688 RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
Query: 460 SLS---KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
L KE ++ + R +++Q LE+ EA R RR++ E Q D+ EQ L +
Sbjct: 748 QLLSQVKELSMVTELRAQVKQ-LEMNLAEAERQRRLDYESQTAHDNLL---TEQIHSLSI 803
Query: 517 AVRER----ERLQEMLMGLEAKQSESLSELITLREAL---ESSHLEG-ELLRQEQTEVTA 568
+ + E LQ L ++ + SE + + +L+ L ES LEG E +R ++V
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
Q E++ + L + D+ + ++ + + ++++QL EE S
Sbjct: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Query: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
+ ++ ++ N L E ++E + E N Q +E Q ++Q E
Sbjct: 924 LGVEIKTLKEQLNLLS---RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHE 980
Query: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE--KEALVREKAALEVRLQ 746
+ ++K+ + + + +AA ++L Q R EE LA E KE + E EV
Sbjct: 981 FDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
Query: 747 AVERD-----------------RQDLAEQLQGLSSAKELLESSL-----FEA--QQQNSV 782
++ +Q ++E+ L ++ LE L F+A +Q N
Sbjct: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
Query: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
++ Q+++ +++ + +IQ + D + +E + + + K
Sbjct: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
Query: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
LE++ A EKE QL++K ++ + + L KA E ++ L LK+Q+ + +Q
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE----KERHLREELKQQKDDYNRLQ 1216
Query: 903 AQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQLERLRQDMKVQKLK 961
Q +E+ + E+ Q++ + R S+ L T Q+E ++ LE + + +
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE----EPLFKATE 1272
Query: 962 EQETTGILQTQLQEAQRELKE--AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
+ T +L++ L E +A Q +A ++ + + +K++L+ +V S+L
Sbjct: 1273 QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332
Query: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
+ + +++++ ++ E + + E E SL L + ++ L+ + Q
Sbjct: 1333 TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-Q 1391
Query: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
+L L++ + + + + LS Q+ EKEA + +++E+ + QL
Sbjct: 1392 PKLDELQKLISKKEEDVSYLSGQLS-------EKEAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA------------SLYS 1187
+ + QLQ+ L + + E + E + Q Q + Q A SL
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
L A G++ E + +S S E D R AL E + +
Sbjct: 1505 ELSLARGTI-ERLTKSLADVESQVSAQNKEKDTVLGR---------LALLQEERDKLITE 1554
Query: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
+ + L + Q L + L+ L +K ++ E++ L+ S E ++W+ K
Sbjct: 1555 MDRSLLENQS----LSSSCESLKLALEGLTEDKEKLVKEIESLK---SSKIAESTEWQEK 1607
Query: 1308 QNSLESE---LMELHETMASLQSRLRRA-ELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
L+ E L++ +E +++ R++ E R E Q L++ + N + LQ A
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
Query: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423
E ++E +R + + K E+E E +R +A E+ A G +E +
Sbjct: 1668 EQEMEE-------MKEKMRKFAKSKQQKILELEEENDRLRA-----EVHPA-GDTAKECM 1714
Query: 1424 ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD---LQQEQIQ 1480
L + A +EE+E ++ + + L K+ + + + LS +++ +++ +Q ++
Sbjct: 1715 ETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLE 1774
Query: 1481 ELEK-------CRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533
EK + +P +E++ R E ++ + ++
Sbjct: 1775 ATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ ++ Q+ LK+++ LE + +E +E ++ + ++ + L
Sbjct: 1835 INNYLQ----QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE 1890
Query: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQER--------DQEVKSQREQIEELQRQ 1645
+ +Q++Q + S++ L+ + +L+ER + + + + + + Q +
Sbjct: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIK 1950
Query: 1646 KEHLTQDLERRDQELM-LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ-- 1702
E L +++ + + L++E+ Q+++++ +++I +E LE+I+ + +E G + +
Sbjct: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
Query: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762
++L++E+ +E K K E + + R + Q E +L+ K+ L Q ++
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE-- 2068
Query: 1763 HRKVGETSL-----LLSQREQEIV-VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
HRK + L LL + E VL L+ +E LQS + + + Q+D
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE--------LQSNKESVKSQMKQKD 2120
Query: 1817 QELEA-LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875
++LE L+Q +++ +++ ++EK DAL+ T+ E L ++ ++L+E L
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180
Query: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
++ A + + L+ + +++ ++ Q E E R +D+ + L
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
Query: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSR--- 1992
++ +E L+ H ++ ++A+ + K LQG+ + LL Q E +R
Sbjct: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
Query: 1993 ---------------SLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE-- 2035
SL+ L SL+ C+ LE +R QE +IQ+ Y++
Sbjct: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
Query: 2036 -DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQ 2094
D+Q ++ ++ EE+ ++++ L + +Q + + +Q +E
Sbjct: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE----------- 2409
Query: 2095 SVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPME--EQSLKLDSLEPR--- 2147
++EL+ L+Q+E+E + L E ++ + L + KT E +Q +LDS
Sbjct: 2410 -IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468
Query: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
LQ + +R+ +Q E R + + L + + A + L+E L++ + + +SE
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 2208 QQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
+L EL R L + + + Q QL EV + + + K
Sbjct: 2526 NAKLDAELIQYREDLNQV------------ITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573
Query: 2268 WRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISK 2327
++L+ ++A L + LQ L +E ++ +L R+ + G+L +
Sbjct: 2574 --EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
Query: 2328 ATASSPTQQDGRGQK--NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELA 2385
A ++ R +S K +AEL++E+V +Q + + + +D + +EL
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED------KLKKELK 2685
Query: 2386 GLHH 2389
LHH
Sbjct: 2686 HLHH 2689
Score = 284 bits (727), Expect = 7e-76
Identities = 532/2462 (21%), Positives = 1023/2462 (41%), Gaps = 430/2462 (17%)
Query: 16 LQLVLEEQ---VLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ- 71
+QL EQ + +LQ Q+ ++ + + + L + L K L+ Q
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 72 --ELEKRLEATGGPIPQRWENVEEPN--LDELLVRLEEEQQRCE-SLAEVNTQLRLHMEK 126
E ++ +E I ++ + V E + + E +V+L EE+ + + QL L + +
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL-LSR 940
Query: 127 ADVVNKALREDVEKLTVDWSRARDELMR--KESQWQMEQEFFKGYLKGEHGRLLSLWREV 184
A+ K E+ +++ + DE+ + S+ +++ EF LK E+ + +
Sbjct: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF--DLLKKENEQRKRKLQAA 998
Query: 185 VTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPA 244
+ R+ L+ S + +L LK E S L T + E + +
Sbjct: 999 LINRKELLQRVSRLEEELANLKDE------SKKEIPLSETERGEVEEDKENKEYSEK--- 1049
Query: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
+ +K QE+E I LK ++ ELQ +L L E ++
Sbjct: 1050 ---CVTSKCQEIE----------IYLKQTISEKEVELQHIRKDLEEKLAAE----EQFQA 1092
Query: 305 MIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA---- 360
++K + +T++ +TN +L++ E S E + +Q++I T +GD++A
Sbjct: 1093 LVKQMNQTLQD-KTNQIDLLQAEIS------ENQAIIQKLITSNTDA--SDGDSVALVKE 1143
Query: 361 --------QGSGHENSLELDSSIFSQFDYQDA-----DKALTLVRSVLTRRRQAVQDLRQ 407
GS EL+ I + ++ +ALT +++L + ++ + LR+
Sbjct: 1144 TVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203
Query: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQ--TVDLQGEVDSLSKE 464
+L ++ N LQ+Q D+ +E + + +L++L + R+++ G+ + D Q S
Sbjct: 1204 ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGL 1263
Query: 465 RELLQKAREELRQQLEVLEQEA---WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521
E L KA E+ Q VLE W + LQG ++ Q + Q +E+ E+
Sbjct: 1264 EEPLFKATEQHHTQ-PVLESNLCPDWPSHSEDASA-LQGGTSVAQIKAQLKEIEA---EK 1318
Query: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
L+ + ++ ++ E+ L+E + LE E L+ E A AE +L
Sbjct: 1319 VELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHE---AEVHAESLQQKLE 1375
Query: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS-RMEAAEQAR 640
SS+ + + LR KL L Q+L+ +EE+ S S ++ E A
Sbjct: 1376 SSQLQI-AGLEHLRELQPKLDEL------------QKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 641 NALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKL 696
+Q ++ E E +AL +T LE Q ++ +E +LQ +L +++++ EEI + K
Sbjct: 1423 TKIQTEIIEQEDLIKAL---HTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 697 SESRHQQEAATTQLEQLHQEAKRQEEV-LARAVQEKEALVREKAALEVRLQAVERDRQDL 755
R Q A ++ E L + QEE+ LAR E+ L + A +E ++ A +++ +
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIER--LTKSLADVESQVSAQNKEKDTV 1537
Query: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
+L L ++ L + + + +N + + L++ ++ +T+ KE + E+ LK
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Query: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
E ++ +++ + ++E + L+ + E +++ E R +QEL
Sbjct: 1598 IAESTEWQEKHK-------ELQKEYEILLQSYENV-SNEAERIQHVVEAVRQ-EKQELYG 1648
Query: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL----- 930
L S E K E E +L+E + EME ++ + + + + +++ E ++ R +
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 931 -----LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTG---ILQTQLQEAQRELK- 981
+ETLL + A ++LER++ + + K Q L ++Q+ + +++
Sbjct: 1709 TAKECMETLLSSN---ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG 1765
Query: 982 --------EAARQHRDDLAALQEESSSLL-----QDKMDLQ------KQVEDLKS----- 1017
EA +H + +E + S+ QD + + + V KS
Sbjct: 1766 NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAV 1825
Query: 1018 --QLVAQDDSQRLVEQEVQEKLR------ETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
+ D+ ++Q Q K R E Q+ + LE EK +L + K+ L
Sbjct: 1826 SKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK 1885
Query: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ--------- 1120
+LQE + +++ L Q +QE +L E + +++E+ + LA+
Sbjct: 1886 MLQEEVT----KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYC 1941
Query: 1121 ----EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL------EALAAEQ 1170
+AQ+ EL S + + L+ + E + QL ES++ + A++
Sbjct: 1942 QDVTDAQIKNELLESEM--KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 1171 QPGNQAQAQAQLASLYSALQQALGSVCES----RPELSGGGDSAPSVWGLEPDQNGARSL 1226
+PGN++ A+ +L L QQ + + + + ++S + ++ ++ + +
Sbjct: 2000 EPGNKSHAK-ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 1227 FKRGPLLTALSAEAVASALHKLHQDLWKTQ-QTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
K + + L L TQ + VL D ++ +E ++ E+ KSQ+
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Query: 1286 ELQDLQRQLSQNQE----EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
+ +DL+R+L Q +E EK + K ++L E + L ET+ +Q L + + +
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE------ 2172
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARA-QASAAGILEEDLRTARS---ALKLKNEEVES 1397
+Q +ENL + V L A + Q +++E + R A++ K EE+
Sbjct: 2173 ----VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 1398 ERERAQALQEQGELKVAQGKALQENLALL----------TQTLAEREEEV-ETLRGQIQE 1446
+ + L++Q + L+ N++ L QT + +++V +TL+G+ +E
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE 2288
Query: 1447 L------------EKQREMQKAALELLSL---------DLKK------------RNQEVD 1473
L Q E+ K EL SL L+K R QE D
Sbjct: 2289 LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD 2348
Query: 1474 LQQ-----EQIQ-ELEKCRSVLEHLPMAVQEREQK----LTVQREQIR----ELEKDRET 1519
+Q EQ++ +L+ R + L + +EQK L+ + E I+ EL + +
Sbjct: 2349 IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV-TLECLALELEENHHKMECQQKLIKE 1578
+ LE+ L + E+++ ++E + + D QL+ TL+ + E + +++ K +
Sbjct: 2409 EIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468
Query: 1579 LEGQRET-----QRVALTHLTLDLEERS--QELQAQSS----QIHDLESHSTVLARELQE 1627
L+ R+ Q++ HL++ LE+ QE A+++ +I L SH L E +
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAK 2528
Query: 1628 RDQEVKSQREQIEEL-----QRQKE----HLTQDLERRDQELMLQ---KERIQVLEDQRT 1675
D E+ RE + ++ +QK+ L Q+ E ++ L+ KE + ED R
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRR 2588
Query: 1676 RQTKILEE------DLEQIKLSLRERGRELTTQRQLMQERAEEG--KGPSKAQRGSLEHM 1727
+ EE ++E +K+S+ + R++T +QE G K + + +
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTA----LQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 1728 KLI-------LRDKEKEVEC-QQEHIHELQELKDQLEQQLQGLHRKVG------------ 1767
+ + + E+E+ C Q+E ++ E++D+L+++L+ LH G
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704
Query: 1768 -----------ETSLLLSQREQEIVVLQQQ--------LQEAREQGELKEQSLQSQLDEA 1808
E LL+ +E + + Q Q LQ +R+ + L+ + D +
Sbjct: 2705 VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
Query: 1809 QRALAQ-------------------------RDQELEALQQEQQQAQGQEERVKEKADAL 1843
+ LAQ + L L++ QQ ++E++ + L
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Query: 1844 QGALEQ------AHMTLKERHGELQDHKEQARRLEE-------ELAVEGRRVQALEEVLG 1890
+ + Q A +L+ L + E+ R+ EE + + VQ+L++ +
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
Query: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
L+ + K L LQQQ + QE E L+ + Q K E LR E+
Sbjct: 2885 SLQNDRDRLLKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Query: 1951 SSRHQEEAARARAEA--LQEALGKAH--AALQGKEQHLLEQAELSRSLEASTATLQ---- 2002
S +H+ R + + E K A+ K+Q L L R L +S++ Q
Sbjct: 2944 SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKV 3003
Query: 2003 -----------ASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD 2048
AS D Q + L L EI ++LR Q+ Q L +++
Sbjct: 3004 QYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKN 3063
Query: 2049 ----------EELRHQQERE-------QLLEKSLAQR--------VQENMIQEKQNLGQE 2083
+ LR Q+ +LEK + + V QEK + ++
Sbjct: 3064 TLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK 3123
Query: 2084 REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
+ EE+R QS E Q L QE+ ELR+ + + + + S EEQ +L+
Sbjct: 3124 SDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3183
Query: 2144 LE 2145
E
Sbjct: 3184 SE 3185
Score = 257 bits (657), Expect = 9e-68
Identities = 512/2574 (19%), Positives = 1063/2574 (41%), Gaps = 345/2574 (13%)
Query: 12 KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQ-EAQQRQATLVRKLQAKV-LQYRSW 69
+P +EE V+ QQ + + S + + SQ +A+Q +VR+ A+ Q R
Sbjct: 174 QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233
Query: 70 CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADV 129
EL + + E + L L +LEE ++ A+V L+ + A+
Sbjct: 234 EDELLQLVTQADV------ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQ 287
Query: 130 VNKALREDVEKL---------TVDWSRARDELMRKESQWQM-EQEFFKGYLKGEHGRLLS 179
N+ L + ++++ TV+ R +++ ++ + ++ E++ L+ E LL
Sbjct: 288 RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLE 347
Query: 180 LWREV------VTFRRHFLEMKSATDRDLMELKAEHV----RLSGSLLTCCLRLTVGAQS 229
+ + + R LE K + ME K H+ + L + C L
Sbjct: 348 QFEQAGQAQAELESRYSALEQKHKAE---MEEKTSHILSLQKTGQELQSACDAL------ 398
Query: 230 REPNGSGRMDGREPAQLLLLLAKT-QELEKEAHERSQELIQLKSQGDLEKAELQDRVTEL 288
++ N D E A + A+T Q+LE + ++S+E+ Q ++ L++ E + +
Sbjct: 399 KDQNSKLLQDKNEQA---VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFP 455
Query: 289 SALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSR-NAQEEKLSLQQVI-- 345
+Q E+ I +L++ V LE L+ L A+ EKLS Q +
Sbjct: 456 DVYNEGTQAVTEEN---IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE 512
Query: 346 ---------KDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLT 396
++++++ + + N S E+ ++ + FSQ K L+++ +
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQ-----KHKELSVLLLEMK 567
Query: 397 RRRQAVQDLRQQLAG--CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL 454
++ + L+ QL G +EA + + Q + + EG+ + K+ E DT GQ L
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE-DT--GQDFPL 624
Query: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL---QGDSA-------- 503
++E L +E+ + + E L VEL+ GD +
Sbjct: 625 MP-----NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG 679
Query: 504 QGQKEEQQE------ELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557
Q ++E + EL L + + + E + +AK+ +L++LI + ++
Sbjct: 680 QCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAF 739
Query: 558 LLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQ 617
E+ + + + + EL + L+ +A+ A + A D + L +
Sbjct: 740 TALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE--AERQRRLDYESQTAHDNL-LTE 796
Query: 618 QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Q+ L E +S ++E + + +Q+ +E +L ++QLQ E E
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL-------QSQLQNKESEVLE 849
Query: 678 LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVRE 737
+R I + EE+ + LS Q+E T+++QL E KR E L + ++EK+ V E
Sbjct: 850 GAERVRHISSKVEELSQALS----QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE 905
Query: 738 KA-ALEVRLQAVERDRQDLAEQLQGLSSAKELL----ESSLFEAQQQNSVIEVTKGQLEV 792
+ ++ ++ + ++ L +++ L LL E+ + ++ N V K +
Sbjct: 906 ISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 793 QIQTVTQAKEVIQGEVRCLKLELDTERSQAE----------QERDAAARQLAQAEQEGKT 842
+KE +Q E LK E + + + + Q +LA + E K
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 843 AL-----EQQKAAHEKEVNQLREKWE---------------KERSWHQQELAKALES-LE 881
+ E+ + +KE + EK E+ Q + K LE L
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 882 REKM------ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL-ETL 934
E+ ++ L+++ +++ +QA+ E + + + ++ + V+L+ ET+
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 935 LQT----------QKELADASQQLERLRQDMKVQKLKEQETTG-ILQTQLQEAQRELKEA 983
+ + + EL + LE+ ++ ++ +KL+E T+ + + QE +R L+E
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQ-KKLQEALTSRKAILKKAQEKERHLREE 1204
Query: 984 ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ--RLVEQE-------VQ 1034
+Q +DD LQE+ ++ ++ Q+ L+ Q+ D + +QE ++
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE 1264
Query: 1035 EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG 1094
E L + E + Q LE ++L + LQ S+ Q ++ ++E +
Sbjct: 1265 EPLFKATEQHHTQPVLE---SNLCPDWPSHSEDASALQGGTSVAQ-----IKAQLKEIEA 1316
Query: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154
E+ EL ++ E+ +K + QL E++ + + L+ E A LQ
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVF----QLQEQINKQGLEIESLKTVSHEAEVHAESLQQ 1372
Query: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214
+L S++ Q+ L + +L LQ+ + E LSG
Sbjct: 1373 KLESSQLQIAGL----------EHLRELQPKLDELQKLISKKEEDVSYLSG--------- 1413
Query: 1215 GLEPDQNGARSLFKRGPLLTALSAEAVASA--LHKLHQDLWKTQQTRDVLRDQVQKLEER 1272
L ++ LT + E + + LH L + D +++++L+
Sbjct: 1414 ----------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD---ERIKQLQVE 1460
Query: 1273 LTDTEAEKSQVHTEL---QDLQRQLSQNQEEKSKWEGKQNSLESELM-------ELHETM 1322
L + + + ++ E Q +QR+L + + + SL+ EL L +++
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL 1520
Query: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
A ++S++ ++ G LLQ ++ L +++ +++E ++ +S+ E L+
Sbjct: 1521 ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR---SLLENQSLSSSC----ESLK 1573
Query: 1383 TARSALKLKNEEVESERE--RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
A L E++ E E ++ + E E + + K LQ+ +L Q+ E E +
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQ-EKHKELQKEYEILLQSYENVSNEAERI 1632
Query: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500
+ ++ + ++E Q+ +L S + K+ E LQ+ + QE+E+ + + + Q++
Sbjct: 1633 QHVVEAV--RQEKQELYGKLRSTEANKKETEKQLQEAE-QEMEEMKEKMRKFAKSKQQKI 1689
Query: 1501 QKLTVQREQIR-ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL---- 1555
+L + +++R E+ +T + +E L + +E + + + L K+ +L
Sbjct: 1690 LELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
Query: 1556 ECLALELEENHHKMECQQKLIKELEG--QRETQRVALTHLTLDLEERSQELQAQSSQIHD 1613
+ L+ E+++ H++E LE + + Q T + ++E + S
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809
Query: 1614 LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
S S A+ + S ++I +Q + L + + ++E KE Q LE++
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869
Query: 1674 RTR----------QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
+ + K+L+E++ ++ L ++ EL+ +L +E AEE K +
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL-KETAEEEKDDLE----- 1923
Query: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
E + L + + + + + Q + LE +++ L + V E Q +E +
Sbjct: 1924 -ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV 1982
Query: 1784 QQQLQEA---REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
+ ++++ + QG KE +S E Q L ++ QE++ LQ++ R +EK
Sbjct: 1983 ESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI-------RYQEKI 2035
Query: 1841 DALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE 1900
AL+ ++ E +L+ KE + E + + + +L D ++E+
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL 2095
Query: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE--- 1957
L L+++ LQ + ++ +K++D++LE R E +H +E
Sbjct: 2096 ADNLKLKKE--------------LQSNKESVKSQMKQKDEDLER-RLEQAEEKHLKEKKN 2140
Query: 1958 ------AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQA- 2010
A R L+E +G+ L K++ + + E S A S+ + Q
Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 2011 HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
R ++EA + + ++ A+ ++EE+R +++ +L+ L Q +
Sbjct: 2201 RDRVIDEAKKWE---------------RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ-MS 2244
Query: 2071 ENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
+M + K N+ + +++I +S + ++ L QK + L+ + + LE H +
Sbjct: 2245 IHMEELKINISRLEHDKQI---WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH 2301
Query: 2131 TSPMEEQSLK--LDSLEPRL---QRELER-------LQAALRQTEAREIEWREKAQDLAL 2178
+S E L+ L SL+ +L LE+ L+ +RQ EA + + L
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361
Query: 2179 SLAQTKASVSSL-QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAE 2237
L ++ S L +E+ M Q + +++ +Q + R+ +KE S E
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421
Query: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGME------KQSWRQR--LEHLQQAVARLEIDRSRL 2289
E+ + L E + + + ME K++ +Q+ L+ ++++ L+ DR R+
Sbjct: 2422 -----EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Query: 2290 QRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCV 2349
QL + E+ +L +EA A + ++ + + D +N AK
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAA----AENNKLKEEIRGLRSHMDDLNSEN--AKLD 2530
Query: 2350 AELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPE 2403
AEL + L +T++ Q++ + Q ++EL + L L +A E
Sbjct: 2531 AELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Score = 236 bits (602), Expect = 2e-61
Identities = 442/2241 (19%), Positives = 903/2241 (40%), Gaps = 311/2241 (13%)
Query: 256 LEKEAHERSQELIQLKSQGDLEK--AELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
L+ E H+ S +Q D+++ A + V EL ++ Q Q + ++ AL+E
Sbjct: 30 LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDE---ALQEER 86
Query: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
+ + +L H K L + K I ++ + G + E L
Sbjct: 87 KAADNKIKKLKLHA----------KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL---- 132
Query: 374 SIFSQFDYQDADKALTL--VRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431
S+ D ++ + + ++ L + + + L+ QL Q Q EE
Sbjct: 133 ---SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ---PAQSSTEMEEFV 186
Query: 432 ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRR 491
++Q+LQ+ TL Q Q E Q A++ +R++ E + R
Sbjct: 187 MMKQQLQEKEEFISTLQAQLSQTQAE-----------QAAQQVVREKDARFETQV----R 231
Query: 492 VNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALES 551
++ + LQ + + E Q++L + R+ E +E L+G ++++
Sbjct: 232 LHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR--------AQVV-------- 275
Query: 552 SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611
+LL+QE T Q + ++ + NTL+ V R + L E + L+
Sbjct: 276 -----DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREES---KILLEKMELE 327
Query: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
L+EE + + E A QA+ L+ + E++ +A E+ T LQK
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
Query: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE-QLHQEAKRQEEVLARAVQE 730
G ELQ+ ++++ ++ + +E Q QLE QL Q++K + L R +
Sbjct: 388 ---GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
+ + + +V + + ++ LQ K ++E +E KG L
Sbjct: 445 QHETASQTSFPDVYNEGTQAVTEENIASLQ-----KRVVE------------LENEKGAL 487
Query: 791 ---EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER----DAAARQLAQAEQEGKTA 843
++++ + E + ++ L+ + T + E D A ++ + AE+ G+
Sbjct: 488 LLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV 547
Query: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
LE + KE++ L E+ +A E + K++L+ + + ++ + E +
Sbjct: 548 LENTFSQKHKELSVLL-----------LEMKEAQEEIAFLKLQLQGK-RAEEADHEVLD- 594
Query: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Q+E ++ + E + ++++ E L+ ++ A + K Q E
Sbjct: 595 QKEMKQMEGEG-IAPIKMKVFLEDTGQDFPLMPNEESSLPAVE---------KEQASTEH 644
Query: 964 ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
++ + L +A ELK + L+A+ + Q ++E LKSQ++ +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCH-------QDELERLKSQILELE 697
Query: 1024 ----DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
+Q + E+ + EK +E N++ +E ++ AD+
Sbjct: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN--------------------ADN-NS 736
Query: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
+AL ++ + + KELS EL R +VK+ E + E Q + E+ + L
Sbjct: 737 SAFTALSEERDQLLSQVKELSMVTEL-RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795
Query: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCES 1199
+ + +A +++ +++L+ + + ++ + SL S LQ V E
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQF-----SEQSTLIRSLQSQLQNKESEVLEG 850
Query: 1200 RPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR 1259
+ + +++L ++ +T + L + +D+ QQT
Sbjct: 851 AERVRHISSKVEEL---------SQALSQKELEITKMD-----QLLLEKKRDVETLQQTI 896
Query: 1260 DVLRDQVQKLE----ERLTDTEAEKSQVHTELQDLQRQL---SQNQEEKSKWEGKQNSLE 1312
+ QV ++ E++ EK + E++ L+ QL S+ +E K + + N +
Sbjct: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS 956
Query: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372
S L + ++ M+ ++ + E Q E +LL+ E + LQAA++ +
Sbjct: 957 SGLKQNYDEMSPA------GQISKEELQHEFDLLKKENEQ---RKRKLQAALINRKELLQ 1007
Query: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL--KVAQGKALQENLALLTQTL 1430
LEE+L + K + E+ER + +E E K K QE L QT+
Sbjct: 1008 RVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKC-QEIEIYLKQTI 1066
Query: 1431 AEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE 1490
+E+E E++ +R ++E E +A ++ ++ L+ + ++DL Q +I E + ++++
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQ---AIIQ 1123
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
L + + +V ++E EH ELE+K +E ++ Q+Q +
Sbjct: 1124 KLITSNTDASDGDSVAL--VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
+ +T L+ + E ++ L +EL+ Q++ L +E+S+E + Q
Sbjct: 1182 EALTSRKAILKKAQ-----EKERHLREELKQQKDDYN----RLQEQFDEQSKENENIGDQ 1232
Query: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQK------ 1664
+ L+ + RE + Q+E +E L + E+ + +L+
Sbjct: 1233 LRQLQ----IQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW 1288
Query: 1665 ----ERIQVLED-----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
E L+ Q Q K +E + +++L + ELT + + + + E+
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ--- 1345
Query: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQ-------------EHIHELQELKDQLEQQLQGL 1762
Q +E +K + + E E Q EH+ ELQ D+L++ +
Sbjct: 1346 -INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK 1404
Query: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822
V S LS++E + +Q ++ E + + L+ Q E + Q EL +
Sbjct: 1405 EEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM 1464
Query: 1823 QQEQQQAQGQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
+Q+ ++ G+E R K++ LQ AL LKE + LQ+ AR E L
Sbjct: 1465 KQKPEEI-GEESRAKQQIQRKLQAALISRKEALKE-NKSLQEELSLARGTIERL------ 1516
Query: 1882 VQALEEVLGDLRAESREQEKAL--LALQQQ----CAEQAQEHEVETRALQDSWLQAQAVL 1935
++L +V + A+++E++ L LAL Q+ + +E ++L S + L
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLAL 1576
Query: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE----LS 1991
+ ++ E L E +S + + A + + L K + L +++ +AE +
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636
Query: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEEL 2051
++ L L + +A+ ++ E+ L+ E E+++ + ++ + QQ + + +EE
Sbjct: 1637 EAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE- 1695
Query: 2052 RHQQEREQLLEKSLAQRVQENMIQEKQNLGQ--EREEEEIRGLHQSVRELQLTLAQKEQE 2109
+ E A+ E ++ ++ + ER + E L + + L +E
Sbjct: 1696 NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEE 1755
Query: 2110 ILELRETQQRN-----NLEAL-PHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTE 2163
+ +L+ + N NLEA H ++T+ EE + + P E + L + R T
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI----PGETEEQDSLSMSTRPTC 1811
Query: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
+ + + A SS E+ +LQ D+L+ LE
Sbjct: 1812 SESVPSAKSAN------PAVSKDFSSHDEINNYLQQI------------DQLKERIAGLE 1853
Query: 2224 KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283
+E+ + + T E E+ L ++S + E L+ LQ+ V ++
Sbjct: 1854 EEKQKNKEFSQTLE----NEKNTLLSQISTKDGE--------------LKMLQEEVTKMN 1895
Query: 2284 IDRSRLQRHNVQLRSTLEQVERERRKLKREAMR--AAQAGSL--EISKATASSPTQQDGR 2339
+ ++Q ++ E E E+ L+ M A GS+ T + +
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1955
Query: 2340 GQKNSDAKCVAELQKE-VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAV 2398
+ + KCV+EL++E L++ + +E + +++Y+ + +E H+ L
Sbjct: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
Query: 2399 AQAPEATVLEAETRRLDESLT 2419
+ E L+ + R E ++
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKIS 2036
Score = 149 bits (376), Expect = 3e-35
Identities = 239/1175 (20%), Positives = 483/1175 (41%), Gaps = 187/1175 (15%)
Query: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA 1183
+L EL T+Q +RA L + + + ++ + E E LA +Q
Sbjct: 12 VLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQ------------ 59
Query: 1184 SLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVAS 1243
L L + + D A L+ ++ A + K+ L A+A +
Sbjct: 60 -----LVVELKDIIRQKDVQLQQKDEA-----LQEERKAADNKIKK----LKLHAKAKLT 105
Query: 1244 ALHKLHQDLWKTQ-----QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD-------LQ 1291
+L+K +++ K Q T +Q+ K ++ T+ E E ++ +LQ+ LQ
Sbjct: 106 SLNKYIEEM-KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164
Query: 1292 RQLSQNQEEKSKWEGKQNS----LESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
QL+Q Q E+ + ++ +L E E +++LQ++L + + + Q +++++
Sbjct: 165 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE----QAAQQVVR 220
Query: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407
QV + +++ QA +++ LR + L+ E + + LQ+
Sbjct: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
Query: 1408 QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK 1467
EL A+ Q N +L+Q L + E E TLR + E +RE K LE + L++ +
Sbjct: 281 --ELTAAE----QRN-QILSQQLQQMEAEHNTLRNTV---ETEREESKILLEKMELEVAE 330
Query: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
R QE++ L LE A Q + + + LE+ + +
Sbjct: 331 RKLSFHNLQEEMHHL------LEQFEQAGQAQAE----LESRYSALEQKHKAEMEEKTSH 380
Query: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
+L L+K Q ++S ++D +L L++ + + + I++LE Q + +
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKL---------LQDKNEQAVQSAQTIQQLEDQLQQKS 431
Query: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE-----LQERDQEVKSQRE----- 1637
++ L + E +Q+S D+ + T E LQ+R E+++++
Sbjct: 432 KEISQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLS 490
Query: 1638 --QIEELQRQKEHLTQDL-----ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
++EEL+ + E L+ + + R E + I +++ R + E + ++
Sbjct: 491 SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550
Query: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
+ ++ +EL+ M+E EE + +KL L+ K E E HE+ +
Sbjct: 551 TFSQKHKELSVLLLEMKEAQEE-----------IAFLKLQLQGKRAE-----EADHEVLD 594
Query: 1751 LKDQLEQQLQGLH--------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ-SL 1801
K+ + + +G+ G+ L+ E + ++++ Q E+ SL
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
Query: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
E + D+ L A+ Q Q + ER+K + L+ +A ++ E
Sbjct: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK 714
Query: 1862 QDHKEQARRLEEEL------------AVEGRRVQALEEV-----LGDLRAESREQEKALL 1904
+L EE A+ R Q L +V + +LRA+ ++ E L
Sbjct: 715 AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLA 774
Query: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
++Q + L + K +D ++E L+ E + Q
Sbjct: 775 EAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIR 834
Query: 1965 ALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024
+LQ + LQ KE +LE AE R + + L +L + ++++ L
Sbjct: 835 SLQ-------SQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLL----- 882
Query: 2025 EIQDQDLRYQEDVQQLQQALAQRDEELRH-----QQEREQLLEKSLAQRVQENMIQEKQN 2079
L + DV+ LQQ + ++D+++ ++ QL E+ + V+ ++E+ N
Sbjct: 883 ------LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLN 936
Query: 2080 L---GQEREEEEIR-------GLHQSVREL----QLTL--AQKEQEILELRETQQRNNLE 2123
L +E ++E++ GL Q+ E+ Q++ Q E ++L+ Q++ L+
Sbjct: 937 LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ 996
Query: 2124 ALPHSHKTSPMEEQSLKLDSLEPRLQ--RELERLQAALRQTEAREIEWREKAQDLALSLA 2181
A + K E ++ LE L ++ + + L +TE E+E ++ ++ +
Sbjct: 997 AALINRK-----ELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYS---- 1047
Query: 2182 QTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216
K S QE+ ++L+ ++ E++ E Q ++ +LE
Sbjct: 1048 -EKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLE 1081
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 289 bits (739), Expect = 3e-77
Identities = 459/2110 (21%), Positives = 893/2110 (42%), Gaps = 323/2110 (15%)
Query: 236 GRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQS 295
G D QL+ L + + + EL+ EK +LQ +L+QS
Sbjct: 129 GNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQ-------GILSQS 181
Query: 296 QKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEE 355
Q ++ + I LRE +++ + L E E S +++ +S+ Q + + +
Sbjct: 182 QDKSL---RRIAELREELQMDQQAKKHLQE-EFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 356 GDNIAQGSGHENSLELDSSIFSQFDYQDAD-----------KALTLVRSVLTRRRQAVQD 404
G LE + +F++ + ++D K L ++ + R+ ++
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
Query: 405 LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT----GERDTLAGQTVDLQGEVDS 460
++ + +E LL + + +E+ Q L+K+ E+ L Q D + ++
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 461 LSKEREL-LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ----EELH 515
L +++ + + + + ++ + LE+ E+E +LR ++ QG+ + QKE+ + EEL
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
A+ ++ +E L+A+ E + + E E L+ EL R +Q V +E+
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE-ERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 576 SIA---------------ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
IA EL+ T + E + A++ S +E L + + Q+ L
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ-SEYLKISQEKEQQESL 535
Query: 621 QLEE-ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
LEE E Q E+ + R+ Q EAE R + E + LE LQ+ + +L
Sbjct: 536 ALEELELQKKAILTESENKLRDLQQ----EAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 680 ADL--------RDIQEEKEEIQKKLSESRHQQEAATTQ-LEQLHQEAKRQEEVLA-RAVQ 729
L ++I E+ + +L +HQQ+A T+ L+ L Q+ + + E L + Q
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 730 EKEALVREKAALEVRLQA-VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
EKE L+++K E+ QA +E + E+L + E L S L E + +E
Sbjct: 652 EKETLLKDK---EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
L+ Q + Q L+ ++D +++ +Q+ D+ + E + ++++ +
Sbjct: 709 VLKDQTDKMKQE----------LEAKMDEQKNHHQQQVDSIIK-------EHEVSIQRTE 751
Query: 849 AAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-- 906
A + ++NQL E KER H +E +E+LE + E L++ +++ Q+ +
Sbjct: 752 KALKDQINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 907 EERTQA-ESALCQMQ---LETEKERVSLLETLLQTQKELADASQQLERLR---QDMKVQK 959
E+T+A E L Q+Q L+ E ER+ L + + + + + D +L+ + QD+ +Q+
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL-MQQ 869
Query: 960 LKEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
L++Q E +++ Q + +L++ ++ L E+ + +LQ + +K++E L
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSI 1077
+L A++DS ++ +E + K + ++ + E ++KA + E ++ L+ QEA
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEK----KMEKVKQKAK---EMQETLKKKLLDQEAKLK 982
Query: 1078 RQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
++ E +AL +E Q K L + + + + + + +E L H E
Sbjct: 983 KELENTALELSQKEKQFNAKMLE-MAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
Query: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC 1197
S+W E +L A E Q ++ Q Q + + Q+ L C
Sbjct: 1042 DVISIW----------------EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 1198 ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA---------LHKL 1248
E + W E +L + L SA + A L KL
Sbjct: 1086 EKEEM------NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKL 1139
Query: 1249 HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQ 1308
DL K+ + L++Q+ +L+ + + + S++ ++L+ + Q KS E
Sbjct: 1140 EVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF---QSLKSSHEKSN 1196
Query: 1309 NSLESELMELHETMASLQSRL----RRAELQRMEAQGERELLQAAKEN-LTAQVEHLQ-- 1361
SLE + +E + L +L ++ E E + ++K N + +++ H Q
Sbjct: 1197 KSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHR 1256
Query: 1362 ------------AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409
V E AQ L E+ T + + ++E + + ++++
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQ---LTEEQNTLNISFQQATHQLEEKENQIKSMKADI 1313
Query: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE------LEKQREMQKAALELLSL 1463
E V + +ALQ+ Q +E+E + L+ ++ E L K+ E+++ +E+ SL
Sbjct: 1314 ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE-ELKEKKVEISSL 1372
Query: 1464 DLKKRNQEVDLQQE-QIQELEKCRSVLE--------HLPMAVQEREQKL-TVQREQIREL 1513
+ + V LQ + E E S L L VQ+ K+ T+ +E+I L
Sbjct: 1373 SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL 1432
Query: 1514 EK----------------DRETQ-RNVLEHQLLELEKKDQMIESQRGQVQDLKKQL---- 1552
E+ R TQ +N ++ ++LE K + + Q+ LK++L
Sbjct: 1433 EQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVA-----LTHLTLDLEERSQELQAQ 1607
+CL E+E++ KME ++ + E E + +T R+ +T T+++E ++ L+
Sbjct: 1493 KRFDCLKGEMEDDKSKMEKKESNL-ETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 1608 SSQIHDLESHSTVLA----REL-QERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ Q D+E V +EL +E+D VK E+I L+ Q + +LE + +EL
Sbjct: 1552 NQQ-KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL-- 1608
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQ---IKLSLRERGRE---LTTQRQLMQERAEEGKGP 1716
E + + + + K LE+ LE KL+ +R E ++QL+ + E+ +
Sbjct: 1609 --EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK-----------------DQLEQQL 1759
K L + L+++E+EV +E + ++ + +Q E
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 1760 QGLHRKVGETSLLLSQRE--QEIVVLQQQLQEARE--------------------QGELK 1797
QG +K E + + QR ++ +LQ+ QE E E K
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA------DALQGALEQAH 1851
+ QS + Q L +++++ + + + +G + ++ K D +Q L++
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 1852 MT-------LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD------LRAESRE 1898
+T +KE L KE R EEL + ++QAL+++ G L + E
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 1899 QEKALLALQQQCAEQAQEH----------EVETRALQDSWLQAQAVL----KERDQELEA 1944
+ K+ L + + +H E E + L ++ Q L KE QELE
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEI 1966
Query: 1945 LRAESQSSRH------QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
L+ E R QE+ L++ + + + L KEQ L + + ++ +
Sbjct: 1967 LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL--EMTIKETINKAQ 2024
Query: 1999 ATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE 2058
L++ Q + QL + + ++ +++ RY+E L R+EE+ +
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE-------ILDAREEEMTAKVRDL 2077
Query: 2059 QLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK-----EQEILEL 2113
Q + L ++ Q+ + QE +N G + + ++ ELQ LAQK + ++ E
Sbjct: 2078 QTQLEELQKKYQQKLEQE-ENPGND---------NVTIMELQTQLAQKTTLISDSKLKEQ 2127
Query: 2114 RETQQRNNLE 2123
+Q +NLE
Sbjct: 2128 EFREQIHNLE 2137
Score = 286 bits (732), Expect = 2e-76
Identities = 443/1963 (22%), Positives = 852/1963 (43%), Gaps = 250/1963 (12%)
Query: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ---KLTGERDTLAGQTVDLQGEV 458
+ +LR++L Q+A LQ++ D EE LQ L +R VD+ +
Sbjct: 189 IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPL 248
Query: 459 DSLSKERELLQKAREELR------------QQLEVLEQEAWR----LRRVNVELQLQGDS 502
L + E+ K + LE L+Q R L+R +Q +
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 503 AQ---GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
+KE QE+L ++E E+++++ M + K L + L E LE +G ++
Sbjct: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQD--KGMVI 366
Query: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK-----LSALNEALALDKVG 614
+ + ++ L E+ IA+L S + T+ +LR K L +AL+ +
Sbjct: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426
Query: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE-AQLQKAEE 673
+ E ++ + + + +E+ R +LQ +L+ ++ + +K++ + A+LQK E
Sbjct: 427 EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
Query: 674 AGAELQADLRDIQEEKEEIQKKL-SESRHQQEAATTQLEQ-------LHQEAKRQEEVLA 725
+++ +++E+ KKL + R QE LE+ + QE ++QE +
Sbjct: 487 ---------KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 726 RAVQ-EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
++ +K+A++ E E +L+ ++++ + ++ L S+ LE SL E + Q+ +
Sbjct: 538 EELELQKKAILTES---ENKLRDLQQEAETYRTRILELESS---LEKSLQENKNQSKDLA 591
Query: 785 V-TKGQLEVQIQTVTQAKEVIQGEVRCLKLELD---TERSQA--EQERDAAARQLAQAEQ 838
V + + + +T E + E+ LK + D TE+ Q +Q + + + EQ
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE-----REKMELEMRLKE 893
E +T L+ ++ + + ++ EK ++ Q EL L R K+E E+ + +
Sbjct: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
Query: 894 QQT-----EMEA-IQAQREEERTQAESALCQMQLETE------KERVSLLETLLQTQ-KE 940
QT E+EA + Q+ + Q +S + + ++ + K++++ LE LL+ + K
Sbjct: 712 DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKH 771
Query: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS 1000
L + +E L D+K + + Q+ + L Q Q E + + + LA LQ++
Sbjct: 772 LKEHQAHVENLEADIKRSEGELQQASAKLDV-FQSYQSATHEQTKAYEEQLAQLQQKLLD 830
Query: 1001 LLQDKMDLQKQVEDLKSQ------------LVAQDDSQRLVEQ--EVQEKLRE-TQEYNR 1045
L +++ L KQV ++++Q + QD Q+L +Q E+++K++ TQ Y
Sbjct: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADS----IRQQELSALRQDM----QEAQGEQK 1097
++ +E+ L+EKE +L ++E I Q+LSA + +E + + K
Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFK 950
Query: 1098 ELSAQMELLRQEVKEKEADF----LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
+ME ++Q+ KE + L QEA+L +ELE + + Q A+ + AQ
Sbjct: 951 NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQAN 1010
Query: 1154 LR-LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPS 1212
+ S+LE EQ + +L + S ++ L E E+
Sbjct: 1011 SAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIH-------E 1063
Query: 1213 VWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER 1272
+ E +Q A K+ LL E + + L ++ K T + L++Q+++
Sbjct: 1064 IQLQEKEQEVAE--LKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAH 1121
Query: 1273 LTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA 1332
+ +++++ L+ L+ L+++ +E + + + L+ E ++ L S+L+
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTT 1181
Query: 1333 ELQRMEAQGERELLQAAKENLTAQVEHL------QAAVVEARAQASAAGILEEDLRTARS 1386
+ + + E + E+ + + + L Q + + +A E + + S
Sbjct: 1182 DEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241
Query: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446
+ + R ++E +K L+ L LT+ + Q++E
Sbjct: 1242 KTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEE 1301
Query: 1447 LEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506
E Q + KA +E L + + +E QQ+ E E C + L + E +T+
Sbjct: 1302 KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESC---ITQLKKELSENINAVTLM 1358
Query: 1507 REQIRELEKD------RETQRNVLEHQLLELEKKDQMIESQR-----------GQVQDLK 1549
+E+++E + + + T NV + L +K+ I S R QVQDL
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
Query: 1550 KQLVTL---ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
++ TL + ALE ++ + K K+ + + + + L + LE +S+E
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWK--KKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Query: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
+ QI+ +L EL ++++ + ++E+ + + E +LE EL Q R
Sbjct: 1477 KDEQIN-------LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET---ELKSQTAR 1526
Query: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERG---RELTTQRQLMQERAEEG---------- 1713
I LED T++T +E E +K +++ +EL + Q QE EE
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
Query: 1714 -----------KGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH-----ELQELKDQLEQ 1757
K + ++ LEH+ L ++ KE+E++ ++ + +L ELK + EQ
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
Query: 1758 QLQGLHRKVGETSLLLSQREQE-----------IVVLQQQLQEAREQGELKEQSLQS-QL 1805
++ + ++ LLSQ E++ + L +LQE + + E+ L+S +
Sbjct: 1647 KIAAIKKQ------LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 1806 DEAQRALAQRDQELEALQQEQQQAQGQ---EERVKEKADALQGALEQAHMTLK----ERH 1858
+++ + R + A EQ++A Q ++ +EK LQ L + L+ E+
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 1859 GELQDHKEQARRLEEELA-VEGRRVQALEE--VLGDLRAESREQEKAL-LALQQQCAEQA 1914
+ H E + +E L +E + E+ ++G L+ E E+ K L + Q ++
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 1915 QEHEVETRA-LQDSWLQAQAVLKERD---QELEALRAESQSSR-HQEEAARARAEALQEA 1969
++ ++ + L++ + Q L+E++ Q LE E S Q+E R E L
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 1970 LGKAHAALQ----GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGE 2025
K A Q K LLE+ +S S L +A LE L E E
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKS--KSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 2026 IQD---QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ 2082
Q + +R Q+D++ L++ HQQE E +L+K Q +E + QE+++L
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRK---------EHQQELE-ILKKEYDQEREEKIKQEQEDL-- 1986
Query: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEI-LELRET-QQRNNLEA-LPHSHKTSPMEEQSL 2139
E + L Q +RE LAQKEQE+ + ++ET + +EA L SH+ +
Sbjct: 1987 --ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ-EETNQLLK 2043
Query: 2140 KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
K+ + L+R +R + L +ARE E K +DL L +
Sbjct: 2044 KIAEKDDDLKRTAKRYEEIL---DAREEEMTAKVRDLQTQLEE 2083
Score = 239 bits (611), Expect = 2e-62
Identities = 397/2039 (19%), Positives = 842/2039 (41%), Gaps = 310/2039 (15%)
Query: 522 ERLQEMLMGLEAKQSESLSELITLR----EALESSHLEGELLRQEQTEVTAALARAEQSI 577
E+L E E+ ++S ++ + LR E+L S ++ L R E + + +S+
Sbjct: 44 EQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKE-SLVRTSSRESL 102
Query: 578 AELSSSENTLKTEV-ADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636
L +T + +D+ + A L +++L +K L Q+L ++E S +
Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSL--NKEQLIQRLRRMERSLSSYRGKYSEL 160
Query: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
A LQ + +K+ + + ++ + L++ E ELQ D + + +EE L
Sbjct: 161 VTAYQMLQRE----KKKLQGILSQSQ--DKSLRRIAELREELQMDQQAKKHLQEEFDASL 214
Query: 697 SESRHQQEAATTQLEQLHQEAKRQE------EVLARAVQEKEALVREKAALE-------- 742
E TQ+ L Q + + L + + E +E+
Sbjct: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
Query: 743 -VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
++ +E +Q + Q L KE ++S + S E + QL+ ++Q + + K
Sbjct: 275 GTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861
++ E L +L ++ EQ +A+ +++ LE + E+E+ QLR +
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK----EEEIAQLRSR 390
Query: 862 WEKERSWHQQELAKALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920
K+ + +EL + E ER E LE L Q EA R + + + + + ++
Sbjct: 391 I-KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA----RRKLKAEMDEQIKTIE 445
Query: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL-------KEQETTGILQTQL 973
+E+ER+SL + L + ++E+ D ++ Q K+QKL KEQE T LQT+
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSE-EQIAKLQKLHEKELARKEQELTKKLQTRE 504
Query: 974 QEAQRELKEAARQHRDDLAAL---QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL-- 1028
+E Q ++K A + + + + +E+ SL ++++LQK+ +S+ +D Q
Sbjct: 505 REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAET 564
Query: 1029 -------VEQEVQEKLRETQEYNR---IQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
+E +++ L+E + ++ + E E+ K + +++M ++ + E +S++
Sbjct: 565 YRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT----ELESLK 620
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
Q+ + + +Q + ++ +ME LR++ E+E + L ++ +++ + + E+ L
Sbjct: 621 HQQDALWTEKLQVLK---QQYQTEMEKLREKC-EQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 1139 RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCE 1198
+L +++LE+L++E +A+ +L S L+ +
Sbjct: 677 E---------------KLDVKQTELESLSSELS--EVLKARHKLEEELSVLKDQTDKM-- 717
Query: 1199 SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQT 1258
+ EL D + Q S+ K H++ Q+T
Sbjct: 718 -KQELEAKMDEQKN-----HHQQQVDSIIKE----------------HEV-----SIQRT 750
Query: 1259 RDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMEL 1318
L+DQ+ +LE L + + + +++L+ + +++ E + K + +S
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE 1378
HE + + +L + + + ++ + ER LL T QV ++A + + A I
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILL-------TKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE 1438
+DL L+ +N E+E ++ ++L + E K+ G QE Q L E+E +
Sbjct: 864 QDLM---QQLEKQNSEME---QKVKSLTQVYESKLEDGNKEQEQTK---QILVEKENMIL 914
Query: 1439 TLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
+R E QK +E+L+ L + + + E+ + + ++ +++
Sbjct: 915 QMR----------EGQKKEIEILTQKLSAKEDSIHILNEEYE------TKFKNQEKKMEK 958
Query: 1499 REQKLTVQREQIRELEKDRETQ-RNVLEHQLLELEKKD--------QMIESQRGQVQDLK 1549
+QK +E +++ D+E + + LE+ LEL +K+ +M ++ + D
Sbjct: 959 VKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAV 1018
Query: 1550 KQLVTLECLALELEENHHKMEC-------QQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+L T + +E H+ E ++KL ++ E +E + L ++ E Q
Sbjct: 1019 SRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ 1078
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
++ + ++ T L E ++D + +EQ+++ L QD + +L
Sbjct: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD----ETKLKA 1134
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR---ELTTQRQLMQERAEEGKGPSKA 1719
E+++V ++ ++ L+E L ++K+ E R ELT++ + E + K +
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 1720 QRGSLEHMKLILRDKEKEVECQ------------QEHIHELQELKDQ-----LEQQLQGL 1762
SLE L + +E+ Q + +EL + L +
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ 1254
Query: 1763 HR--KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE 1820
HR KV E L+ + E+ +QL E + + Q QL+E + + ++E
Sbjct: 1255 HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
+L E++ Q + ++ A + + Q LK+ EL ++ ++EEL +
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQ----LKK---ELSENINAVTLMKEELKEKKV 1367
Query: 1881 RVQALEEVLGDLRAESR------EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
+ +L + L DL + + E+E A+ +L++Q E+ E + +QD + +
Sbjct: 1368 EISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQ---VQDLSFKVDTL 1424
Query: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
KE+ LE + S ++ A++R Q + + L+ K + E+ E L
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL 1484
Query: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR------- 2047
+ D + + + +E ++ + + +L+ + Q+
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544
Query: 2048 DEELRHQQEREQLLEKSLAQRVQ--ENMIQEKQNLGQEREEE-------------EIRGL 2092
+E L++ +++ + K L Q++Q + + +EK N +E EE+ E+
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604
Query: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE- 2151
+ + + L++ KE+E+ L + + + L + + + ++K L ++E
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664
Query: 2152 ---------LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202
L L L++ E EK + + S ++T S + VA + +
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQE-- 1722
Query: 2203 ERDSE---QQRLQDELELTRRAL-EKERL-----HSPGATSTAELGSRGEQGVQLGEVSG 2253
E DS+ Q+ ++++ + +R L EKE+L T ++ R + +L ++
Sbjct: 1723 EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH 1782
Query: 2254 VEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQ--RHNVQLRSTLEQV-------- 2303
EA+ D ++ LE + + + + ++N+Q + LE V
Sbjct: 1783 AEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842
Query: 2304 ----------ERERRKLKREAMRAAQAGSLEISKATAS-----SPTQQDGRG------QK 2342
E++ ++L +R + +E+ + T+ + Q DGR ++
Sbjct: 1843 QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEE 1902
Query: 2343 NSDAKCVA------------------------------ELQKEVVLLQAQLTLERKQKQ 2371
N++ K + +L KE+V LQ L + RK+ Q
Sbjct: 1903 NTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Score = 231 bits (588), Expect = 9e-60
Identities = 393/1857 (21%), Positives = 766/1857 (41%), Gaps = 316/1857 (17%)
Query: 27 LQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQ 86
L++Q +++ A++ +L+ + Q+ RKL+A++ + + +EK E + Q
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ---IKTIEKTSEEERISLQQ 457
Query: 87 RWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWS 146
V++ +D + EE+ + + L E R E + RE E++ V
Sbjct: 458 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA-RKEQELTKKLQTREREFQEQMKVALE 516
Query: 147 RARDELMR----KESQWQMEQEFF----KGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
+++ E ++ KE Q + E K L +L L +E T+R LE++S+
Sbjct: 517 KSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576
Query: 199 DRDLMELKAEH----VRLSGSLLTCCLRLTVGAQSREPNGSG---RMDGREPAQLLLLLA 251
++ L E K + V L +TV + + + D +L +L
Sbjct: 577 EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ 636
Query: 252 KTQ----------ELEKEAHERSQELI----------QLKSQGDLEKAELQDRVTELSAL 291
+ Q E EKE + +E+I + + D+++ EL+ +ELS +
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 292 LTQSQKQNEDY-------EKMIKALRETVEILETNHTE-----LMEHEASLSRNAQEEKL 339
L K E+ +KM + L ++ + +H + + EHE S+ R +
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK---- 752
Query: 340 SLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRR 399
+L+ I + ++ E ++ + H +LE D + R
Sbjct: 753 ALKDQINQLELLLKERDKHLKEHQAHVENLEAD----------------------IKRSE 790
Query: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
+Q +L Q + +Q +EE+ L+Q+L L ER L Q +++ +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519
+ E + + ++L QQLE +Q + ++V Q+ + +EQ++ + V
Sbjct: 851 DVCTELDAHKIQVQDLMQQLE--KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
+ + +M G + K+ E L++ ++ +E +S H+ E + + + +Q E
Sbjct: 909 KENMILQMREG-QKKEIEILTQKLSAKE--DSIHILNEEYETKFKNQEKKMEKVKQKAKE 965
Query: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALD--KVGLNQQLLQLEEENQSVCSRMEAAE 637
+ + TLK ++ D + A +K N AL L + N ++L++ + N + S +
Sbjct: 966 M---QETLKKKLLD-QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRL 1021
Query: 638 QARNALQVDLAEAEKRRE-----ALWEKNTHLEA---------QLQKAEEAGAELQADLR 683
+ Q++ RRE ++WEK + +A QLQ+ E+ AEL+ +
Sbjct: 1022 ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081
Query: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
EKEE+ K+++ + + T L +L ++ K++ + Q++ L LEV
Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV 1141
Query: 744 RLQAVERDRQDLAEQL----------------------------QGLSSAKELLESSLFE 775
L ++ L EQL Q L S+ E SL +
Sbjct: 1142 DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED 1201
Query: 776 AQ---------------------------QQNSVIEVTKGQLEVQIQTV-------TQAK 801
+ N +I ++ + + + T+ K
Sbjct: 1202 KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK 1261
Query: 802 EVIQGEVRCLKLELDTERSQAEQERDA-------AARQLAQAEQE-------------GK 841
E + + C EL+ + Q +E++ A QL + E + K
Sbjct: 1262 EALLIKT-CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK 1320
Query: 842 TALE-----QQKAAHEKE--VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894
AL+ QQ+AA EKE + QL+ KE S + + E L+ +K+E+ L +Q
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLK----KELSENINAVTLMKEELKEKKVEIS-SLSKQ 1375
Query: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL--------------LQTQKE 940
T++ +Q Q ++ E+A+ ++ + ++E+ LL+ + + ++
Sbjct: 1376 LTDLN-VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQ 1434
Query: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE----------LKEAARQHRDD 990
+ D S + ++ + + + Q T LQ QL+ +E LKE Q
Sbjct: 1435 VDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKR 1494
Query: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
L+ E + DK ++K+ +L+++L +Q +E + +K E + N + K
Sbjct: 1495 FDCLKGE---MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 1051 EREKASLTLSLMEKEQRLLVLQEADSIR----QQELSALRQDMQEAQGEQKELSAQMELL 1106
++K L++K Q L E R ++++ L + + E + ++E +
Sbjct: 1552 NQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHV 1611
Query: 1107 RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
VK KE + A E +L E + A L + KA Q ++ + + QL +
Sbjct: 1612 NLSVKSKEEELKALEDRL----------ESESAAKLAELKRKAEQ---KIAAIKKQLLSQ 1658
Query: 1167 AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL 1226
E++ + ++ L+ L + LQ+ V +L +E Q+
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK----------SVESSQSET--- 1705
Query: 1227 FKRGPLLTALSAEAVASALHKLHQD----LWKTQQTR-DVLRDQVQKLEERLTDTEAEKS 1281
L+ SA+ VA+ + D + KT + + VL+ + + E+ L EK
Sbjct: 1706 -----LIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
+ + +++ Q + + E KQ+ +S + L E + + Q +E +G
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSAL-------KLKNEE 1394
+ +Q AK+NL + +Q + E ILE+ ++ S L +++ EE
Sbjct: 1821 GKNNIQ-AKQNLENVFDDVQKTLQEKELTCQ---ILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 1395 VESERERAQALQE-QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE----- 1448
+ S+ E+ QALQ+ G K + L+EN +++ + + + + Q +LE
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTE--LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
+RE QK E++ L R L++E QELE + + QERE+K+ ++E
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRM----LRKEHQQELEILKKEYD------QEREEKIKQEQE 1984
Query: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
+ EL K T + ++ +L +K+Q +E +K+ + + + EL E+H +
Sbjct: 1985 DL-EL-KHNSTLKQLMREFNTQLAQKEQELE------MTIKETINKAQEVEAELLESHQE 2036
Query: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ-- 1626
E Q L K E + +R A + + L+ R +E+ A ++ DL++ L ++ Q
Sbjct: 2037 -ETNQLLKKIAEKDDDLKRTAKRYEEI-LDAREEEMTA---KVRDLQTQLEELQKKYQQK 2091
Query: 1627 -ERDQEVKSQREQIEELQ---RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679
E+++ + I ELQ QK L D + ++QE +E+I LED+ + K
Sbjct: 2092 LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF---REQIHNLEDRLKKYEK 2145
Score = 172 bits (435), Expect = 5e-42
Identities = 296/1421 (20%), Positives = 604/1421 (42%), Gaps = 213/1421 (14%)
Query: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSA 1210
+L+ ++ + QL+ A Q + + ++ S S+ + L +R GD+
Sbjct: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRES----GDTQ 59
Query: 1211 PSVWGLEPDQNGARSLFK---RGPLLTALSAEAVA--SALHKLHQ-DLWKTQQTRDVLRD 1264
L+ SLF+ + L + S E++ S+ L++ DL + + D D
Sbjct: 60 SFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSD 119
Query: 1265 QVQKLEERLTDTEA-EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323
+ E+ + ++++ K Q+ L+ ++R LS + + S+ L+ E +L ++
Sbjct: 120 MDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS 179
Query: 1324 SLQSR-LRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
Q + LRR R E Q +++ + +E A +E + + Q S +L++ LR
Sbjct: 180 QSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS---LLKQRLR 236
Query: 1383 TARSALKLKNE--EVESERE---RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
+ + ++E + E + + + GE V G +++ L L Q + +E +
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK-TLETLQQRVKRQENLL 295
Query: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV----DLQQEQ----IQELEKCRSVL 1489
+ + IQ ++Q + + E L L +R QE+ DL + I +L ++++
Sbjct: 296 KRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLI 355
Query: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL-----EKKDQMIESQRGQ 1544
E L Q++ + + Q+ E + +E + L ++ ++ E ++Q +S+R
Sbjct: 356 EQLE---QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA 412
Query: 1545 VQDLKKQLVTLECLALELEENHHKMECQQ-KLIKELEGQRETQRVALTHL-------TLD 1596
++L+K L T A + EE K++ + + IK +E E +R++L +D
Sbjct: 413 FEELEKALST----AQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 1597 LEERSQELQ-AQSSQIHDLE--SHSTVLARELQERDQEVKSQRE-QIEELQRQKEHLTQD 1652
+ ++S E Q A+ ++H+ E L ++LQ R++E + Q + +E+ Q + ++Q+
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 1653 LERRD----QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
E+++ +EL LQK+ I + + R DL+Q + R R EL + +++
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLR-------DLQQEAETYRTRILELESS---LEK 578
Query: 1709 RAEEGKGPSKAQRGSLEHMK-------LILRDKEK----EVECQQEHI--HELQELKDQL 1755
+E K SK LE K ++ +K K ++ QQ+ + +LQ LK Q
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 638
Query: 1756 EQQLQGLHRKVG-ETSLLLSQREQEIVVLQQQLQEAREQG-------ELKEQSLQSQLDE 1807
+ +++ L K E LL +E ++ Q ++E E+ + + +SL S+L E
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKE---IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695
Query: 1808 AQRALAQRDQELEALQQE-------------------QQQAQG----QEERVKEKADALQ 1844
+A + ++EL L+ + QQQ E ++ AL+
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 1845 GALEQAHMTLKERHGELQDHKEQARRLEEELA-VEGRRVQALE--EVLGDLRAESREQEK 1901
+ Q + LKER L++H+ LE ++ EG QA +V ++ + EQ K
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961
A Q ++ + E E L + +A K+ EL+A + + Q Q E +
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
Query: 1962 RAEALQEALGKAHAA---------------LQGKEQHLLEQAE-LSRSLEASTATLQASL 2005
E ++L + + + L KE +L+ E + +E T L A
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935
Query: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL----- 2060
D+ + + E + QE +++ + +E + L++ L ++ +L+ + E L
Sbjct: 936 DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995
Query: 2061 --------LEKSLAQ---------RVQENMIQEKQNLGQ--EREEEEI-----RGLHQSV 2096
LE + A R++ N ++ ++L + RE ++ + L+Q
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 2097 RELQ----LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152
ELQ + L +KEQE+ EL++ E + + + ++E+ +K D+ LQ +L
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Query: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212
++ A + E + + + L + L ++ + LQE + L+ E + L
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP-------------- 2258
+L+ T E + L S S L + + +L E ++ +
Sbjct: 1176 SKLKTTDE--EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 2259 ---SPDGMEKQSWRQRLEHLQQ--------------AVARLEIDRSRLQRH----NVQLR 2297
+ + + R+ H Q V+ LE +L N+ +
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 2298 STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAK---CVAELQK 2354
Q+E + ++K +M+A +E S T Q++G Q+ + ++ C+ +L+K
Sbjct: 1294 QATHQLEEKENQIK--SMKA----DIE-SLVTEKEALQKEGGNQQQAASEKESCITQLKK 1346
Query: 2355 EVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL 2395
E+ +TL +++ ++ + S++L L+ L +S+
Sbjct: 1347 ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Score = 155 bits (392), Expect = 5e-37
Identities = 285/1427 (19%), Positives = 595/1427 (41%), Gaps = 174/1427 (12%)
Query: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKR---L 77
EEQ+ LQQ++ + + K E + ++ + +L A +Q + Q+LEK+ +
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 78 EATGGPIPQRWE------NVEEPNLDELLVRLEEE--QQRCESLAEVNTQLRLHMEKADV 129
E + Q +E N E+ ++LV E Q R E+ + K D
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
Query: 130 VNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL--------LSLW 181
++ L E+ E + + +++ +K + QE K L + +L L L
Sbjct: 938 IH-ILNEEYETKFKNQEKKMEKVKQKAKEM---QETLKKKLLDQEAKLKKELENTALELS 993
Query: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
++ F LEM A + + + RL + LT RE N + +
Sbjct: 994 QKEKQFNAKMLEMAQANSAGISDAVS---RLETNQKEQIESLT-EVHRRELNDVISIWEK 1049
Query: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN-- 299
+ Q L + E++ + E+ QE+ +LK + L E ++ E++ L + KQ+
Sbjct: 1050 KLNQQAEELQEIHEIQLQ--EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 300 -EDYEKMIKALRETVEILETNHTELMEH----EASLSRNAQEEKLSLQQVIKDITQVMVE 354
+ ++ +K V L + T+L H E L+++ +E LQ+ + ++ + E
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF-LQEQLVELKMLAEE 1166
Query: 355 EGDNIAQ---------------GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRR 399
+ +++ S HE S + S +++ + L + + ++
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNK--SLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
+A+ + A E +N+ + + + R K+ +L+ ++
Sbjct: 1225 EALLE-----AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519
L++E+ L + ++ QLE E + ++ L + ++ Q + QQ+ A
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ----AAS 1335
Query: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARA---EQS 576
E+E + L+ + SE+++ + ++E L+ +E L ++ T++ L + +
Sbjct: 1336 EKE---SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 577 IAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL----LQLEEENQSVCSR 632
A +SS E +L LS + L+ +K+ +Q+ + E + SR
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
Query: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
+ LQ+ L E + + +EK+ + ++ ++ +++++K ++
Sbjct: 1453 FTQHQNTVKELQIQL---ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDR 752
+KK S + ++ T ++ +L E+ + + E E+L L+ Q + +
Sbjct: 1510 EKKESNLETELKSQTARIMEL-------EDHITQKTIEIESL---NEVLKNYNQQKDIEH 1559
Query: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
++L ++LQ E ++ + EA+++ +E ++ +++T + E + V+ +
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE 1619
Query: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE 872
EL + E E A +L + ++ A+++Q + ++ + E+++K H E
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS---QMEEKEEQYKKGTESHLSE 1676
Query: 873 LAKALESLEREKMELEMRLKE-QQTEMEAIQAQRE-------EERTQAESALCQMQLETE 924
L L+ ERE LE +LK + ++ E + R E+ +A+S C +T
Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTY 1734
Query: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK--- 981
+E++S+L Q+ L + + L+R+ Q+ KE+ + + + Q +R +K
Sbjct: 1735 EEKISVL------QRNLTEKEKLLQRVGQE------KEETVSSHFEMRCQYQERLIKLEH 1782
Query: 982 EAARQHRDD--LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
A+QH D + LQEE L++K S +VAQ + + +Q K
Sbjct: 1783 AEAKQHEDQSMIGHLQEE----LEEK-------NKKYSLIVAQHVEKEGGKNNIQAKQNL 1831
Query: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
++ +QK L+ ++ LT ++E++ ++E DS ++ R +M+E + ++L
Sbjct: 1832 ENVFDDVQKTLQEKE--LTCQILEQK-----IKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
Query: 1100 SA--QM-------ELLRQEVKEKEADFLAQEAQLLEELEASH------ITEQQLRASLWA 1144
A QM ELL + +EK L Q +LL +EA H + +
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQ-PKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 1145 QEAKAAQLQLRLRSTESQ--LEALAAEQQPGNQAQAQAQLASL----YSALQQALGSVCE 1198
+E Q LR+ E Q LE L E + + + + L S L+Q + E
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMR---E 2000
Query: 1199 SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQT 1258
+L+ + +Q ++ + + AE + S + +Q L K +
Sbjct: 2001 FNTQLA------------QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK 2048
Query: 1259 RDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMEL 1318
D L+ ++ EE L E E + +LQ +L + ++K + E + +MEL
Sbjct: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
Query: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
+A + + ++L+ E RE + ++ L +++ A V
Sbjct: 2109 QTQLAQKTTLISDSKLKEQEF---REQIHNLEDRLKKYEKNVYATTV 2152
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1044
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1105 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1152
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1328
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1329 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1383
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1435
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1436 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1481
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1534
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1535 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1585
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1678
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1915
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2211
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2212 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2496 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2545
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2651
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2652 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2698
Query: 2236 AEL 2238
A L
Sbjct: 2699 AGL 2701
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 365 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 405
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 406 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 575
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 576 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 631
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 632 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 691
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 692 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 742
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 743 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 801
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 982 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1041
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1162 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1219
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1220 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1272
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1330
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1331 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1375
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1426
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1483
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1484 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1529
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1707
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1708 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1755
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1869
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2047 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2092
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2147
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2148 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2206 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2261
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2318
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2319 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2497 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2550
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2551 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2665
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Query: 2428 VLL 2430
L+
Sbjct: 2726 ALI 2728
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 858 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 911
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 912 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 970
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 971 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1015
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1016 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1060
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1061 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1538 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1817
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1818 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2055
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2176 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2234 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2410
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2411 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2466
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2467 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2521
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2522 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2573
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2574 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2625 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2663
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2664 LSAEELQRLAQGHTTVDELARRED 2687
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1155
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1156 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1275 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1391 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1448 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1737
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1783
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1899
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2140 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2192
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2307
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2308 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2533
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2594 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2647
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2648 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2682
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1592
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1593 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1641
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1642 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1680
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1681 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1722
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1781
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1902 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1952 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 2003
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 2004 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2048
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2221
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2459
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2460 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2638 AEAEP 2642
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 169 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 228
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 229 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 285
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 286 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 345
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 346 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 401
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 402 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 458
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 578
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 579 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 628
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 629 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 689 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 739
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 859
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 860 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 919
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 920 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 978
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1036
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1096
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1097 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1332 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1445
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1682
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1683 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1741 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1919 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1977 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 994 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1048
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1049 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1108
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1109 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1156
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1157 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1216
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1332
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1333 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1387
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1439
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1440 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1485
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1538
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1539 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1589
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1682
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1919
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2215
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2216 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2449 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2500 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2549
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2550 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2610 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2655
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2656 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2702
Query: 2236 AEL 2238
A L
Sbjct: 2703 AGL 2705
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 369 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 409
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 410 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 462
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 463 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 522
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 523 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 579
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 580 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 635
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 636 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 695
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 696 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 746
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 747 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 805
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 806 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 865
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 866 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 925
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 926 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 985
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 986 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1045
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1046 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1105
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1166 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1223
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1224 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1276
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1334
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1335 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1379
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1430
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1487
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1488 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1533
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1711
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1712 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1759
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1873
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2051 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2096
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2151
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2152 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2210 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2265
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2322
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2323 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2501 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2554
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2555 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2613 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2669
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2670 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2729
Query: 2428 VLL 2430
L+
Sbjct: 2730 ALI 2732
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 862 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 915
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 916 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 974
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 975 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1019
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1020 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1064
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1065 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1542 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1821
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1822 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2059
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2119
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2179
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2180 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2238 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2414
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2415 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2470
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2471 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2525
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2526 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2577
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2578 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2629 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2667
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2668 LSAEELQRLAQGHTTVDELARRED 2691
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1159
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1160 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1278
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1279 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1334
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1395 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1452 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1568
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1741
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1787
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1903
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2144 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2196
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2311
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2312 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2537
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2598 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2651
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2652 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2686
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1543 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1596
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1597 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1645
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1646 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1684
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1685 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1726
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1785
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1906 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1956 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 2007
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 2008 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2052
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2225
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2226 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2286 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2404
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2463
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2464 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2641
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2642 AEAEP 2646
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 173 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 232
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 233 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 289
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 290 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 349
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 350 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 405
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 406 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 462
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 463 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 522
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 523 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 582
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 583 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 632
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 633 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 692
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 693 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 743
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 744 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 804 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 863
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 864 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 923
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 924 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 982
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 983 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1040
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1041 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1100
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1101 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1155
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1156 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1215
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1216 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1275
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1335
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1336 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1449
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1627
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1686
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1687 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1745 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1922
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1923 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1981 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 990 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1044
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1105 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1152
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1328
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1329 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1383
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1435
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1436 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1481
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1534
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1535 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1585
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1678
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1915
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2211
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2212 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2445 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2496 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2545
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2651
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2652 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2698
Query: 2236 AEL 2238
A L
Sbjct: 2699 AGL 2701
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 365 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 405
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 406 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 575
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 576 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 631
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 632 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 691
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 692 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 742
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 743 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 801
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 802 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 861
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 862 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 921
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 981
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 982 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1041
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1162 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1219
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1220 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1272
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1330
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1331 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1375
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1426
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1483
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1484 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1529
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1707
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1708 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1755
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1869
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2047 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2092
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2147
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2148 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2206 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2261
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2318
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2319 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2497 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2550
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2551 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2665
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Query: 2428 VLL 2430
L+
Sbjct: 2726 ALI 2728
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 858 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 911
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 912 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 970
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 971 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1015
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1016 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1060
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1061 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1538 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1817
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1818 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2055
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2176 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2234 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2410
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2411 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2466
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2467 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2521
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2522 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2573
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2574 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2625 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2663
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2664 LSAEELQRLAQGHTTVDELARRED 2687
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1155
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1156 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1275 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1391 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1448 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1737
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1783
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1899
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2140 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2192
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2307
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2308 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2533
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2594 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2647
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2648 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2682
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1592
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1593 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1641
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1642 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1680
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1681 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1722
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1781
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1902 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1952 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 2003
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 2004 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2048
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2221
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2222 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2459
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2460 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2638 AEAEP 2642
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 169 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 228
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 229 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 285
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 286 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 345
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 346 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 401
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 402 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 458
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 578
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 579 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 628
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 629 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 689 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 739
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 859
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 860 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 919
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 920 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 978
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1036
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1037 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1096
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1097 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1332 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1445
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1682
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1683 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1741 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1919 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1977 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 958 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1012
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1013 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1072
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1073 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1120
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1121 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1180
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1296
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1297 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1351
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1403
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1404 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1449
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1502
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1503 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1553
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1646
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1883
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2179
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2180 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2413 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2464 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2513
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2514 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2574 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2619
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2620 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2666
Query: 2236 AEL 2238
A L
Sbjct: 2667 AGL 2669
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 333 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 373
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 374 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 426
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 427 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 486
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 487 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 543
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 544 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 599
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 600 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 659
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 660 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 710
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 711 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 769
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 770 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 829
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 830 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 889
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 890 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 949
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 950 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1009
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1010 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1069
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1130 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1187
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1188 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1240
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1298
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1299 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1343
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1394
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1451
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1452 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1497
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1675
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1676 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1723
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1837
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2015 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2060
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2115
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2116 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2174 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2229
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2286
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2287 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2465 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2518
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2519 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2577 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2633
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2634 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2693
Query: 2428 VLL 2430
L+
Sbjct: 2694 ALI 2696
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 826 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 879
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 880 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 938
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 939 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 983
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 984 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1028
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1029 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1506 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1785
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1786 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2023
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2083
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2143
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2144 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2202 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2378
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2379 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2434
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2435 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2489
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2490 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2541
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2542 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2593 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2631
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2632 LSAEELQRLAQGHTTVDELARRED 2655
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1123
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1124 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1242
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1243 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1298
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1358
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1359 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1416 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1532
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1705
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1751
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1867
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2108 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2160
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2275
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2276 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2501
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2562 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2615
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2616 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2650
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1507 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1560
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1561 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1609
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1610 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1648
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1649 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1690
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1749
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1870 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1920 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 1971
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 1972 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2016
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2189
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2190 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2250 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2368
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2427
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2428 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2605
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2606 AEAEP 2610
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 137 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 196
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 197 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 253
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 254 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 313
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 314 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 369
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 370 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 426
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 427 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 486
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 487 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 546
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 547 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 596
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 597 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 656
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 657 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 707
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 708 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 768 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 827
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 828 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 887
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 888 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 946
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 947 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1004
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1005 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1064
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1065 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1119
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1120 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1179
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1180 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1239
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1299
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1300 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1413
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1533
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1591
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1650
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1651 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1709 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1886
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1887 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1945 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 1127 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1181
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1182 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1241
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1242 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1289
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1465
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1466 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1520
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1572
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1573 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1618
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1671
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1672 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1722
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1815
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1875
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 2052
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2348
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2349 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2582 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2633 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2682
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2683 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2743 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2788
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2789 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2835
Query: 2236 AEL 2238
A L
Sbjct: 2836 AGL 2838
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 502 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 542
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 543 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 595
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 596 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 655
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 656 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 712
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 713 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 768
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 769 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 828
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 829 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 879
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 880 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 938
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 939 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 998
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1118
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 1119 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1178
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1179 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1238
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1299 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1356
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1357 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1409
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1467
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1468 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1512
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1563
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1620
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1621 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1666
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1844
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1845 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1892
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 2006
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2184 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2229
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2284
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2285 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2343 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2398
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2455
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2456 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2634 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2687
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2688 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2746 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2802
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2803 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2862
Query: 2428 VLL 2430
L+
Sbjct: 2863 ALI 2865
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 995 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 1048
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 1049 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 1107
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 1108 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1152
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1153 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1197
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1198 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1675 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1954
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1955 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2192
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2252
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2312
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2313 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2371 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2547
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2548 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2603
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2604 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2658
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2659 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2710
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2711 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2762 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2800
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2801 LSAEELQRLAQGHTTVDELARRED 2824
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1292
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1293 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1412 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1467
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1528 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1585 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1701
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1874
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1920
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 2036
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2277 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2329
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2444
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2445 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2670
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2731 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2784
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2785 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2819
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1676 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1729
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1730 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1778
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1779 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1817
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1818 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1859
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1918
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 2039 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 2089 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 2140
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 2141 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2185
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2358
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2537
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2596
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2597 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2775 AEAEP 2779
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 306 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 365
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 366 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 422
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 423 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 482
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 483 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 538
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 539 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 595
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 596 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 655
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 656 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 715
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 716 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 765
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 766 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 826 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 876
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 877 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 937 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 996
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 997 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 1056
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 1057 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 1115
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1173
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1174 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1233
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1234 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1348
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1349 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1408
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1468
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1469 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1582
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1702
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1760
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1819
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1820 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1878 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 2056 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 2114 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 968 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1022
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1023 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1082
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1083 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1130
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1306
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1307 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1361
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1413
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1414 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1459
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1460 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1512
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1513 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1563
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1656
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1893
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2189
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2190 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2423 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2474 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2523
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2524 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2584 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2629
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2630 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2676
Query: 2236 AEL 2238
A L
Sbjct: 2677 AGL 2679
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 343 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 383
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 384 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 436
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 437 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 496
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 497 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 553
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 554 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 609
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 610 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 669
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 670 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 720
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 721 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 779
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 780 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 839
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 840 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 900 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 959
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 960 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1019
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1020 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1079
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1140 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1197
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1198 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1250
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1308
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1309 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1353
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1404
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1461
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1462 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1507
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1685
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1686 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1733
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1847
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2025 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2070
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2125
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2126 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2184 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2239
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2296
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2297 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2475 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2528
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2529 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2587 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2643
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2644 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2703
Query: 2428 VLL 2430
L+
Sbjct: 2704 ALI 2706
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 836 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 889
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 890 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 948
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 949 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 993
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 994 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1038
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1039 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1516 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1795
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1796 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2033
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2093
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2153
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2154 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2212 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2269
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2388
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2389 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2444
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2445 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2499
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2500 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2551
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2552 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2603 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2641
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2642 LSAEELQRLAQGHTTVDELARRED 2665
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1133
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1134 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1253 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1308
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1369 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1426 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1542
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1715
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1761
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1877
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2118 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2170
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2285
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2286 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2511
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2572 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2625
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2626 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2660
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1517 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1570
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1571 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1619
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1620 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1658
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1659 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1700
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1759
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1880 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1930 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 1981
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 1982 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2026
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2199
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2378
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2437
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2438 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2616 AEAEP 2620
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 147 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 206
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 207 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 263
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 264 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 323
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 324 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 379
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 380 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 436
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 437 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 496
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 497 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 556
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 557 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 606
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 607 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 667 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 717
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 718 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 778 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 837
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 838 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 897
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 898 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 956
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 957 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1014
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1015 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1074
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1075 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1189
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1190 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1249
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1309
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1310 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1423
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1543
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1601
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1660
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1661 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1719 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1897 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1955 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2008
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 976 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1030
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1031 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1090
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1091 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1138
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1139 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1198
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1314
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1315 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1369
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1421
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1422 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1467
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1468 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1520
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1521 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1571
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1664
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1901
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2197
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2198 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2431 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2482 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2531
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2532 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2592 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2637
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2638 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2684
Query: 2236 AEL 2238
A L
Sbjct: 2685 AGL 2687
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 351 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 391
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 392 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 444
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 445 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 504
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 505 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 561
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 562 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 617
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 618 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 677
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 678 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 728
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 729 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 787
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 788 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 847
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 848 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 907
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 908 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 967
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 968 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1027
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1028 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1087
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1148 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1205
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1206 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1258
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1316
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1317 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1361
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1412
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1469
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1470 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1515
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1693
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1694 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1741
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1855
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 1973 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2032
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2033 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2078
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2133
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2134 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2192 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2247
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2304
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2305 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2483 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2536
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2537 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2595 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2651
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2652 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2711
Query: 2428 VLL 2430
L+
Sbjct: 2712 ALI 2714
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 844 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 897
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 898 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 956
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 957 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1001
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1002 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1046
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1047 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1524 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1803
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1804 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2041
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2101
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2161
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2162 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2220 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2277
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2396
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2397 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2452
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2453 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2507
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2508 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2559
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2560 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2611 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2649
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2650 LSAEELQRLAQGHTTVDELARRED 2673
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1141
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1142 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1260
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1261 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1316
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1376
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1377 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1434 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1550
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1723
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1769
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1885
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2126 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2178
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2293
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2294 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2519
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2580 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2633
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2634 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2668
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1525 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1578
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1579 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1627
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1628 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1666
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1667 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1708
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1767
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1888 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1938 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 1989
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 1990 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2034
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2207
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2208 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2268 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2386
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2445
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2446 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2623
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2624 AEAEP 2628
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 155 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 214
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 215 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 271
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 272 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 331
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 332 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 387
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 388 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 444
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 445 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 504
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 505 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 564
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 565 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 614
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 615 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 674
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 675 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 725
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 726 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 786 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 845
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 846 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 905
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 906 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 964
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 965 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1022
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1023 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1082
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1083 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1137
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1138 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1197
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1198 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1257
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1317
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1318 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1431
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1551
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1609
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1668
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1669 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1727 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1904
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1905 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 1963 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2016
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 286 bits (731), Expect = 2e-76
Identities = 423/1863 (22%), Positives = 767/1863 (41%), Gaps = 248/1863 (13%)
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
+++R QLE E R+ ++ + + AQ E+Q+ A E E L + + L
Sbjct: 1017 KDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK-----AQAEVEGLGKGVARLS 1071
Query: 533 AKQSESLS------ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
A+ + L+ TLR LE + + E +R L I +E
Sbjct: 1072 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1131
Query: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
L+ L+ A + L E L K L + Q E A + +AL+ +
Sbjct: 1132 LRAHEEQLKEAQAVPATLPE-LEATKASLKKLRAQAE-----------AQQPTFDALRDE 1179
Query: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAEL----QADLRDIQEEKEEIQKKLSESRHQ 702
L A++ E L +++ + ++++ E A+L QA L + E+++ + R+
Sbjct: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
Query: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE----Q 758
+E+A L +RQE++ A + + +A+ + + L+ +ER + + E
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
Query: 759 LQGLSSAKEL-LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Q +++ K+ L+ ++AQ + K +++ ++V Q E + ++R EL T
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ--EYV--DLRTHYSELTT 1355
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
SQ + R++ + E+ EQQ+A + + ++ EK+R + A+A
Sbjct: 1356 LTSQYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAK 1410
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
ERE EL+ R++E+ E ++++ + L Q++ +E E +Q
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE--------IQA 1462
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ A+A+++ +L+ +E +++ QL+ +R+ A +L AL+
Sbjct: 1463 KARQAEAAER----------SRLRIEEEIRVVRLQLEATERQRGGA----EGELQALRAR 1508
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ K Q++ E L+ Q+ QD+SQR + EV+ R E E REK
Sbjct: 1509 AEEAEAQKRQAQEEAERLRRQV--QDESQRKRQAEVELASRVKAE-----AEAAREKQRA 1561
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
+L +E RL + +RQ E+ RQ + Q+ A E++ K A F
Sbjct: 1562 LQAL--EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA-------ELQSKRASF 1612
Query: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
+ AQL L+ H+ QLR + + A+ + E +LE + + +
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
QA+ + +L QA + E R +RG
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAE---------------------REARRRG------K 1705
Query: 1238 AEAVASALHKL-HQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
AE A +L Q+L K +Q + Q E+ L AE Q + Q L+ +L++
Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1765
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE----------LQRMEAQGER--E 1344
Q E + K+ LE+EL ++ M L + RAE QR+EA+ R E
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825
Query: 1345 LLQ-AAKENLTAQVEHLQAAVVE---ARAQASAAGILEEDLRTARSALKLKNE------E 1394
L + AA+ A+ Q + E AR +A A +L E L A +LK E E
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885
Query: 1395 VESERERAQALQEQG-------ELKVAQGKA-LQENLALLTQTLAEREEEVETLRGQIQE 1446
E+E ER + L E E + AQ KA ++E LA L + + E+E +G +++
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA---SDSELERQKGLVED 1942
Query: 1447 LEKQREM------------QKAALELLSLDLK----KRNQEVDLQQEQIQELEKCRSVLE 1490
+QR +KAA L+L+ + N E L+ ++ ELE R
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+ RE + VQ+ E E R+ + + E + L+ + ++ +R + + ++
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062
Query: 1551 QLVTLECLA--LELEENHHKMECQQK-------------LIKELEGQRETQRVALTHLTL 1595
+ E L+ EE H QQK ++ +L G+ E R A
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQE---VKSQREQIEELQRQKEHLTQD 1652
+ +E Q+ + E + Q R Q + R++ E+ ++ Q
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
R+ Q + E+ + +Q RQ +E++L ++L L E Q+ L+ E +
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH----QKNLLDEELQR 2238
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL--------HR 1764
K ++A + + ++ E+E+ + + EL +LK ++E + + L R
Sbjct: 2239 LK--AEATEAARQRSQV-----EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 1765 KVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821
+ E + + Q +E L QEA +L E+ L Q A++ L ++ Q E
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
L+ E + Q Q+E +E+A LQ EQ L E Q E R+ + E++ E R
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
++ + +A + E + ++ E+ E+ T+ + ++ D +
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
E LR ++E + A+ LQ L+ +E ++Q +L + +A +
Sbjct: 2472 AERLREAIAELEREKEKLQQEAKLLQ---------LKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
+ D+ R +E+ E + +Q++V + QQ R+E+ R QQ+ EQ
Sbjct: 2523 LSEKDSLLQRERFIEQ-------EKAKLEQLFQDEVAKAQQL---REEQQRQQQQMEQER 2572
Query: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
++ +A + Q + G R++EE++ L Q R+ + LA++ Q + E + + +
Sbjct: 2573 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
Query: 2122 LEALPHSHKTSPMEEQSLKL-----DSLE-PRLQRELERLQAALRQTEAREIEWREKAQD 2175
AL HS + + + + K D+L+ P + E E LR+
Sbjct: 2633 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR-------------- 2678
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
K S LQE A L A L+R ++ D EL RR E R + G +S
Sbjct: 2679 --------KVSAQRLQE-AGILSAEELQRLAQGHTTVD--ELARR--EDVRHYLQGRSSI 2725
Query: 2236 AEL 2238
A L
Sbjct: 2726 AGL 2728
Score = 279 bits (713), Expect = 3e-74
Identities = 592/2523 (23%), Positives = 1042/2523 (41%), Gaps = 388/2523 (15%)
Query: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
DVEK +W + ++ +E Q L+ E RL L R V L+M++
Sbjct: 392 DVEK---EWGKLHVAILEREKQ-----------LRSEFERLECLQRIVTK-----LQMEA 432
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMD-GREPAQLLLLLAKTQE 255
L E + + +LL +RL + + G D + + + LL Q
Sbjct: 433 G-------LCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 485
Query: 256 LEKEAHERSQE-----------LIQLKSQGDLE-KAELQDRVTELSALLTQS-QKQNEDY 302
L+ H + ++ L+ ++++ +L KA + T+++ + QS Q++ E
Sbjct: 486 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 545
Query: 303 EKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
+ ++ L++ + +E N + E + + E +L + + Q + E I +
Sbjct: 546 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH---RGLHQSIEEFRAKIERA 602
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR----RRQAVQDLRQQLAGCQEAVNL 418
E L S ++ Y+D L L + L R ++++ L +A + +
Sbjct: 603 RSDEGQL----SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMW 658
Query: 419 LQQQHDQ-----WEEEGK---ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
L ++ ++ W + A ++ L E + + +LQ D L +E +
Sbjct: 659 LNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP 718
Query: 471 AREELRQQLEVLEQEAWRLRRVN-VELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEML 528
E + L+ Q +W L+ +E L+ ++A Q VRE E +LQ++
Sbjct: 719 TVESFQAALQT--QWSWMLQLCCCIEAHLKENAAYFQ-------FFSDVREAEGQLQKLQ 769
Query: 529 MGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
L K S S +T L + L+ + E E L + + ++ LA+ +++ +L
Sbjct: 770 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAH 828
Query: 588 KTE-------VADLRAAAVKLSALNEAL-----------ALDKVGLNQQLLQL------- 622
V D + V + +E L G + +
Sbjct: 829 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 888
Query: 623 EEENQSVCSRMEAAEQAR----NALQVDLA--------------------------EAEK 652
+E Q +R+EA QA + L VD+ + E+
Sbjct: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948
Query: 653 RREALWEKNTHLEAQLQKAEEAGA---------------------ELQADLRDIQEEKEE 691
+R+AL H +A L+ +++AG +L L +E+
Sbjct: 949 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1008
Query: 692 IQKKLSES---RHQQEAATTQL-----------------EQLHQEAKRQEEV--LARAVQ 729
Q+ +SE R Q EA T+ +++ ++ K Q EV L + V
Sbjct: 1009 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVA 1068
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
A + AL A R +L L L + L L + + + VI T+G
Sbjct: 1069 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1128
Query: 790 LEVQIQTVTQAKEV-----IQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGK 841
EV Q KE E+ K L R+QAE ++ DA +L A++ G+
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
L+Q+ + EV + RE+ + Q LA+ + +RE +L +L+ + + +
Sbjct: 1189 R-LQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPL 1246
Query: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
A ++ R + E Q+Q + ++ E L Q Q L + + E++ + Q+
Sbjct: 1247 GAWLQDARRRQE----QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE---CQRFA 1299
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
+Q I +LQ + + +Q S S++Q+ +DL+ +L +
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT-- 1357
Query: 1022 QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
SQ + + + E LR +E R+ E+++A E+ +RL ++ A ++Q
Sbjct: 1358 ---SQYI--KFISETLRRMEEEERLA---EQQRA-------EERERLAEVEAALEKQRQL 1402
Query: 1082 LSALRQDMQEAQGEQKELSAQM--ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
A Q +A+ E KEL +M E++R+E E D Q+ + EEL QQLR
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRRE--EAAVDAQQQKRSIQEEL-------QQLR 1453
Query: 1140 ASLWAQ-EAKAAQLQL----RLRSTES----QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
S A+ +AKA Q + RLR E +L+ A E+Q G A+ +L +L + +
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG---AEGELQALRARAE 1510
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+A +++ E + R L + + AEA A+ +
Sbjct: 1511 EAEAQKRQAQEEAER--------LRRQVQDESQRKRQAEVELASRVKAEAEAA------R 1556
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKS-QVHTELQDLQRQL-SQNQEEKSKWEGKQ 1308
+ + Q + LR Q ++ E RL E E++ QV L+ QR ++ Q +++ + K
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 1309 NSLESELMELHETMASLQSRLRR-----AELQRMEAQGERELLQ---AAKENLTAQVEHL 1360
LE L E H +A L+ R AE +R + EREL + A E L +++
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+ A ++ AQA A EE R AR K + + V Q L++Q +L A+G A Q
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL--AEGTAQQ 1734
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
A E+E+ LR + ++ E+QR++ + L L + Q+ +QE
Sbjct: 1735 RLAA---------EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK---RQELEA 1782
Query: 1481 ELEKCRSVLEHL--PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ-----LLELEK 1533
EL K R+ +E L A E E + T ++ + R LE + R + E L E K
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-LEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
+ + + + Q + + V E LA E K E + L KE E + E R L
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAENERLR----RL 1896
Query: 1594 TLDLEERSQELQAQSSQIH-DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
D + + L+ Q++Q D+E LA+ + D E++ Q+ +E+ RQ+ + ++
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEER---LAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Query: 1653 L------------ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE-QIKLSLRERGREL 1699
+ + + EL L + R + R+++ LE + Q+ R RE
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013
Query: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQEHIHELQELKDQLEQQ 1758
+ Q EE KA +E +K + + + E +QE +LQ ++ +++
Sbjct: 2014 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073
Query: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL-DEAQRALAQRDQ 1817
LQ + + + Q+EQE LQQ LQ+ EQS+ QL EA+ A ++
Sbjct: 2074 LQAEEKA---HAFAVQQKEQE---LQQTLQQ--------EQSVLDQLRGEAEAARRAAEE 2119
Query: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
EA Q +++A +V+E Q A EQA + + Q E+ R+ E+ A
Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQA-----QARAQAQAAAEKLRKEAEQEAA 2174
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-EHEVETRALQDSWLQAQAVLK 1936
RR QA + L +A E EK +Q ++AQ E E+ T LQ Q L
Sbjct: 2175 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 1937 ERDQELEALRAES-----QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLL------ 1985
D+EL+ L+AE+ Q S+ +EE R + E L K A ++ + + L+
Sbjct: 2233 --DEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARIEAENRALILRDKDN 2288
Query: 1986 ------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
E+AE + + A L + A RQL E Q+ + ++ L+ E +Q
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLK--EKMQA 2345
Query: 2040 LQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER-------EEEEIRGL 2092
+Q+A + E QQ++E L + A+R+QE+ Q Q L +E E E R L
Sbjct: 2346 VQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 2093 HQSVR--ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME----EQSLKLDSLEP 2146
S L+L +A+ + E QR +A K E E+ + +LE
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 2147 RLQR---ELERLQAALRQTEAREIEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASV 2201
+ Q+ + ERL+ A+ + E + + +++A+ L L QT LQE Q+ +
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 2202 LERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPD 2261
E+DS QR E + + + E+L +L R EQ Q ++ E +
Sbjct: 2524 SEKDSLLQR---ERFIEQEKAKLEQLFQDEVAKAQQL--REEQQRQQQQMEQ-ERQRLVA 2577
Query: 2262 GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE---RERRKLKREAMRAA 2318
ME+ R+R ++ V R + + +L++ Q L + RE+ +L E RAA
Sbjct: 2578 SMEEA--RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Query: 2319 QAGSLEISKA-TASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
A S E++ + A++ T +GR + A AE + L+ +++ +R Q+ + S
Sbjct: 2636 LAHSEEVTASQVAATKTLPNGRDALDGPA-AEAEPEHSFDGLRRKVSAQRLQEAGIL--S 2692
Query: 2378 AQTSRELAGLHHSLS--------HSLLAVAQAPEATVLEAETRRLD--ESLTQSLTSPGP 2427
A+ + LA H ++ L + +L+A +L +L + L SPG
Sbjct: 2693 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2752
Query: 2428 VLL 2430
L+
Sbjct: 2753 ALI 2755
Score = 271 bits (694), Expect = 4e-72
Identities = 448/1944 (23%), Positives = 809/1944 (41%), Gaps = 342/1944 (17%)
Query: 91 VEEPNLD--ELLVRLEEEQQRCESLAEVNTQLRLHME-KADVVNKALREDVEKLTVDWSR 147
V PN + E + RLE + Q A V +LH++ K+ + ++LR DV+ L WS
Sbjct: 885 VPPPNQEAQEAVTRLEAQHQ-----ALVTLWHQLHVDMKSLLAWQSLRRDVQ-LIRSWSL 938
Query: 148 ARDELMRKESQWQMEQEF---FKGYLK--------GEHGRLLSLWREVVTFRRHFLEMKS 196
A ++ E Q Q ++ +L+ G RL++ RE + H+ ++
Sbjct: 939 ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-REYGSCSHHYQQLLQ 997
Query: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+ ++ E ++ R L L+L + R +L L L K E
Sbjct: 998 SLEQGAQE-ESRCQRCISELKDIRLQLEA------------CETRTVHRLRLPLDK--EP 1042
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
+E +R E Q K+Q ++E L V LSA + EK++ AL E
Sbjct: 1043 ARECAQRIAE--QQKAQAEVEG--LGKGVARLSA----------EAEKVL-ALPEPSPAA 1087
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG--SGHENSLELDSS 374
T +EL E +L + Q LS + K T +V G A+ HE L+ +
Sbjct: 1088 PTLRSEL---ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
Query: 375 IFSQFDYQDADKA-LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +A KA L +R+ ++ LR +L G QE LQQ+H + + E +
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------------------- 468
R+R+ +L + QT Q E++ L ++
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 469 ----QKAREELRQQLEVLEQ----------------------EAWRLRRVNVELQLQGDS 502
Q RE+LRQ+ +LE+ + + L+ V + QL+ +
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
Query: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI-TLREALESSHLEGELLRQ 561
+ +K + Q ++E L+ L S+ + + TLR E L + +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
Query: 562 EQ---TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD----KVG 614
E+ EV AAL + Q + ++ + E +L+ + E A+D K
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
Query: 615 LNQQLLQL----EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
+ ++L QL E E Q+ + EAAE++R ++ ++ + EA + E +LQ
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKL---SESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
E +A R QEE E +++++ S+ + Q E + EA R+++ +A
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 728 VQEKEALVREKAALEVRLQAVERDRQ--------------DLAEQLQGLSSAKELLESSL 773
++E L E+A +R VER RQ +L + + LE SL
Sbjct: 1565 LEELR-LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 774 FE---------------AQQQ--------NSVIEVTKGQLE--------VQIQTVTQAKE 802
E AQQQ + E+ + QL+ +Q + V Q K
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE------QQKAAHEKEVN 856
+ Q E K E + E + + + A RQ AEQE + + QQ+ A E+E+
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
Query: 857 QLR---EKWEKERSWHQQELA---KALESLEREKMELEMRLKEQQTEMEAIQAQ--REEE 908
+LR E+ E++R ++ELA + + +++ ELE L + + EME + A R EE
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 909 RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI 968
+++ S + +LE E R +ELA+ + +L L ++ K Q+
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRF----------RELAEEAARLRALAEEAKRQR--------- 1844
Query: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDL-QKQVEDLKSQLVAQDDS-- 1025
Q ++A R+ EA R + LAA+ E + + ++ L +K+ E+ + + +A+D++
Sbjct: 1845 -QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 1026 -QRLVEQEVQEKLRETQEYNRIQK----ELEREKASLTLSLMEK---EQRLLVLQEA--- 1074
+RL EQ Q K + +++K ELER+K + +L ++ E+ +L L+ +
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 1075 --------------------DSIR---QQELSALRQDMQEAQGE----------QKELSA 1101
D++R Q EL A RQ A+ E QK L+A
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 1102 QMELLRQ-------------------EVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
+ E RQ ++E+ A++ QL +E + ++ +A
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-KAHA 2082
Query: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA---------- 1192
+A + K +LQ L+ +S L+ L E + +A +A+ A + + + A
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2142
Query: 1193 -LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQD 1251
L E + + +A E +Q AR L A HK +
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2202
Query: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
+T + + + ++ L +L +T+ +K+ + ELQ L+ + ++ ++S+ E + S+
Sbjct: 2203 --QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
++ EL + A +++ R L+ + + LQ E + E V A+ A
Sbjct: 2261 RVQMEELSKLKARIEAENRALILR--DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2318
Query: 1372 SAAGILEEDLRTARS-ALKLKNEEVESERE------RAQALQEQGELKVAQGKALQENLA 1424
+ EEDL R+ A K+ E++++ +E A+ LQ+Q EL Q + LQE+
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 1425 LLTQTLAEREEEVE-TLRGQIQ-ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
+ Q LAE + + TL + Q +LE E ++ L + + + E D Q+ + ++
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR-KQA 2437
Query: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
E+ L +A QE+ VQ +I+ + D + +R L + ELE++ + ++ +
Sbjct: 2438 EEIGEKLHRTELATQEK--VTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQEA 2493
Query: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
+Q +++ T++ L L+E QQ + E + + +R + LE+ Q
Sbjct: 2494 KLLQLKSEEMQTVQQEQL-LQET---QALQQSFLSEKDSLLQRERF-IEQEKAKLEQLFQ 2548
Query: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
+ A++ Q+ + + R+ Q+ +QE + +EE +R++ + + R+ +EL
Sbjct: 2549 DEVAKAQQLREEQQ------RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-- 2600
Query: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722
Q LE QR +Q ++L E+ ++ LRE+ + L Q + +EE A
Sbjct: 2601 -----QQLEQQRRQQEELLAEENQR----LREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Query: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+L + + L E E E GL RKV +QR QE +
Sbjct: 2652 TLPNGRDALDGPAAEAE---------------PEHSFDGLRRKVS------AQRLQEAGI 2690
Query: 1783 LQQQLQEAREQGELKEQSLQSQLD 1806
L + + QG L + D
Sbjct: 2691 LSAEELQRLAQGHTTVDELARRED 2714
Score = 225 bits (573), Expect = 5e-58
Identities = 359/1659 (21%), Positives = 701/1659 (42%), Gaps = 265/1659 (15%)
Query: 21 EEQVLALQQQMAENQA------------ASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
EE + A ++Q+ E QA AS +KL+ EAQQ +R + R
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD------ELRG 1182
Query: 69 WCQELEKRLEATGGPIP---QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHME 125
QE+ +RL+ G +RW L+ L + R L ++ QLR + E
Sbjct: 1183 -AQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
Query: 126 KADVVNKAL------REDVEKLTVDWSRARDELMRKESQWQME-----------QEFFKG 168
AD + L +E ++ + + S+A E +R+E E Q F K
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301
Query: 169 YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV-------RLSGSLLTCCL 221
Y+ L L VT++ + S + ++ +E V R S LT
Sbjct: 1302 YINAIKDYELQL----VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1357
Query: 222 RLTVGAQS---REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
+ S R R+ ++ A+ LA+ + ++ + ++ Q K+Q + E
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
Query: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338
ELQ R+ E + + ++ D ++ ++++E ++ L + ++ +A + A+ +
Sbjct: 1418 KELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL------DSSIFSQFDYQDADKALTLVR 392
L +++ I+ + ++ +E + Q G E L+ ++ + ++A++ V+
Sbjct: 1475 LRIEEEIR-VVRLQLEATER--QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 393 SVLTRRRQAVQDLRQQLAG-------CQEAVNLLQQQHDQWEEEGKALRQ-------RLQ 438
R+RQA +L ++ Q A+ L++ Q EE + LRQ ++Q
Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1591
Query: 439 ------------KLTGERDTLAGQTVDLQ--------------GEVDSLSKERELLQKAR 472
+L +R + A +T L+ E + ++++ ++AR
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 473 EELRQQLE---VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--------------- 514
EE ++LE + EA RLR E+ Q AQ + E+Q+EE
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711
Query: 515 ---HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
LA +E E+ +++ G ++ + ELI LR E + +LL +E LA
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE-------LA 1764
Query: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
R ++ A + L+ E+A +RA E L K + EEE++S
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEM-------EVLLASKA-------RAEEESRSTSE 1810
Query: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
+ + +A +LAE R AL E+ + Q Q AEE A +A+ + EK
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEE---AKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 692 IQKKLSESRHQQEAATTQLEQLHQEAKR--QEEVLARAVQEKEALVREKAALEVRLQAVE 749
+ + + + E A + E ++ +R ++E R E++A + KA +E RL +
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLR 1926
Query: 750 RDRQDLAEQLQGL---------SSAKEL--LESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
+ E+ +GL +E+ L++S +A + +E+ G++ +
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 799 QAKEVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE--QQKAAHEK 853
++KE + E R L E + R +AE+ + +A ++ K ALE ++ A +
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046
Query: 854 EVNQLREKWEKERSWHQQELAKALE------------SLEREKMELEMRLKEQQTEMEAI 901
E +LRE+ E+E + Q +A + ++++++ EL+ L+++Q+ ++ +
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 902 QAQREEERTQAESA-LCQMQLETE----KERVSLLETLLQTQKELADASQQLERLRQDMK 956
+ + E R AE A ++Q E E + +V E L Q+ +E A A Q + + ++
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
KE E + Q ++A K+AA + E++ L+ K +++++ L+
Sbjct: 2167 ----KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT---LRQKAQVEQELTTLR 2219
Query: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL---------MEKEQR 1067
QL D + L+++E+Q E E R + ++E E S+ + + +E E R
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279
Query: 1068 LLVLQEADSIR---QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
L+L++ D+ + Q+E ++Q +EA + ++AQ +++ E++ LAQ+ L
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEA--ARLSVAAQEAARLRQLAEED---LAQQRAL 2334
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
E++ +++++A QEA + + L + +L A + ++ Q QLA
Sbjct: 2335 AEKM-----LKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Q+ L + + + E+S A + + + A++ + AE +
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443
Query: 1245 LHKLH---QDLWKTQQTRDVLRDQ----VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
LH+ Q+ QT ++ R Q ++L E + + E EK ++ E + LQ + +
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 1298 Q-------------------EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Q EK ++ +E E +L + Q + +A+ R E
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---FQDEVAKAQQLREE 2560
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEA----RAQASAAGILEEDLRTARSALKLKNEE 1394
Q +++ ++ ++ L A +E + EA R + LE+ R L +N+
Sbjct: 2561 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
+ RE+ Q L+EQ +A + + + T+TL + L G E E +
Sbjct: 2621 L---REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAEPEHSFD 2674
Query: 1455 KAALELLSLDLKKRNQEVD-LQQEQIQELEKCRSVLEHL 1492
++ + +R QE L E++Q L + + ++ L
Sbjct: 2675 GLRRKVSA----QRLQEAGILSAEELQRLAQGHTTVDEL 2709
Score = 177 bits (449), Expect = 1e-43
Identities = 277/1205 (22%), Positives = 509/1205 (42%), Gaps = 147/1205 (12%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQEL 73
+ L+L EE L+Q E R+++ + E QR A +LQ+K + +L
Sbjct: 1566 EELRLQAEEAERRLRQAEVERA----RQVQVALETAQRSAEA--ELQSKRASFAEKTAQL 1619
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E+ L+ + Q E E R +++ + + E +L KA N+A
Sbjct: 1620 ERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAERELERWQLKA---NEA 1668
Query: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
LR ++ +E+ +++S Q E E K + E RR E
Sbjct: 1669 LRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE------------ARRRGKAE 1707
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
++ R+L E + E R Q E R+ + +L+ L A+T
Sbjct: 1708 EQAVRQRELAEQELEKQR----------------QLAEGTAQQRLAAEQ--ELIRLRAET 1749
Query: 254 QELEKEAHERSQELIQLKSQG--------DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
++ E++ +EL +L+ + +LE AEL E+ LL + E+
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRST 1808
Query: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ---G 362
+ ++ +E EL E A L A+E K Q +D + E +A+
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 363 SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
G L+ ++ I + + ++ L +RR+ + Q A +E + L++
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
D E K L + DTL Q ++ E+ +L E + EL +L +
Sbjct: 1929 SDSELERQKGLVE---------DTLR-QRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
A R + +L+ A Q++ EE ER+Q+ L A + E+ +
Sbjct: 1979 RSNAEDTLRSKEQAELE---AARQRQLAAEEERRRREAEERVQKSL----AAEEEAARQ- 2030
Query: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
+ ALE E E L+ + E RAEQ E+ + ++A AA +L
Sbjct: 2031 --RKAALE----EVERLKAKVEEARRLRERAEQ--------ESARQLQLAQ-EAAQKRLQ 2075
Query: 603 ALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNALQVDLAEAEKRREALWEK 660
A +A A Q+L Q ++ QSV ++ EA R A + + A + REA +
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 661 NTHLEAQ-LQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
EA+ L+++ E A+ +A + E+ ++E +++ + ++AA Q + E +
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
+ ++ + +++K + +E L ++L+ + + L E+LQ L++ EA +
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAAR 2248
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE--------LDTERSQAEQERDAAA 830
Q S +E + VQ++ +++ K I+ E R L L L E + +Q + AA
Sbjct: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Query: 831 R------QLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSWHQQELAKALESLERE 883
R + A+ Q + L QQ+A EK + + ++ E R + EL + + L +E
Sbjct: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Query: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
+ KEQ + A + Q + +AE Q+++ E ER+ L + + A+
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQARAE 2427
Query: 944 AS-----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+Q E + + + +L QE ++QT L+ +++ A + R+ +A L+ E
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREK 2486
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
L Q+ LQ + E++ Q V Q+ + + Q L E + ++ +E+EKA L
Sbjct: 2487 EKLQQEAKLLQLKSEEM--QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Query: 1059 LSLMEKEQRLLVLQEADSIRQQELSALRQ----DMQEAQGEQKELSAQMELLRQEVKEKE 1114
++ + L+E +QQ++ RQ M+EA+ Q E + ++E+++ E
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
Query: 1115 ADFLAQEAQLLEE----LEASHITEQQLRASL-WAQEAKAAQLQL--RLRSTESQLEALA 1167
QE L EE E + E+Q RA+L ++E A+Q+ L + L+ A
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Query: 1168 AEQQP 1172
AE +P
Sbjct: 2665 AEAEP 2669
Score = 152 bits (383), Expect = 5e-36
Identities = 410/1916 (21%), Positives = 748/1916 (39%), Gaps = 302/1916 (15%)
Query: 753 QDLAEQLQGL---SSAKELLESSLFEA---QQQNSVIEVTKGQLEVQIQTVTQAKEVIQG 806
Q + E QGL + + LF A + + +I++ K + ++ + QA V +
Sbjct: 196 QRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAER 255
Query: 807 EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
++ +L LD E Q + + + + + + N+L+ +W++ R
Sbjct: 256 DLGVTRL-LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDG--VRANELQLRWQEYR 312
Query: 867 S-------WHQQELAKALE-----SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
W + A E S E ++ LK ++ E+ A +A + + +S
Sbjct: 313 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS 372
Query: 915 ALCQMQ------------LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
+Q L+ EKE L +L+ +K+L ++LE L++ + K
Sbjct: 373 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIV----TKL 428
Query: 963 QETTGILQTQLQEAQRELKEAAR--------QHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Q G+ + QL +A L+ R Q ++ +++ S+++ L V+
Sbjct: 429 QMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIR---LLFNDVQT 485
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQ-EYN-RIQKELEREKASLTLSLMEKEQRLLVLQ 1072
LK Q + + E+L + EYN R++ + + ++ QR L+
Sbjct: 486 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 545
Query: 1073 EADSIRQQELSALRQDMQ---------------EAQ-GEQKELSAQMELLRQEVKEKEAD 1116
++ Q+L A ++ Q EAQ G + L +E R +++ +D
Sbjct: 546 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSD 605
Query: 1117 FLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL----QLRLRSTESQLEALAA---- 1168
E QL S T R L + + A+L + RLRS ES +AA
Sbjct: 606 ----EGQL------SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE 655
Query: 1169 --------EQQPG----NQAQAQAQLASLYSALQQALGSVCESRPELSGGGD-------- 1208
E++ G ++ YSAL + L + EL GD
Sbjct: 656 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-KLHQDLWKTQQTRDVLRDQVQ 1267
+ P+V + S + L + A +A + + D+ + + Q+Q
Sbjct: 716 ARPTVESFQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSDVREAE-------GQLQ 766
Query: 1268 KLEERL-TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
KL+E L ++S T L+DL + +E+ ++++G + L + +
Sbjct: 767 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826
Query: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQV----------------------------- 1357
+ R L + +++ + Q+
Sbjct: 827 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVP 886
Query: 1358 ---EHLQAAVVEARAQASAAGILEEDLRT-ARSALKLKNEEVESERERAQALQEQGELKV 1413
+ Q AV AQ A L L +S L ++ + + R+ +L LK
Sbjct: 887 PPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 946
Query: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA--LELLSLDLKKRNQE 1471
+ + +L L Q ++ G L +RE + + L L++ QE
Sbjct: 947 EEQRQALHSLELHYQAFLRDSQDAGGF-GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQE 1005
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q I EL+ R LE R +L + +E RE + R ++ + ++ L
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHR-LRLPLDKEPARECAQ-RIAEQQKAQAEVEGL 1063
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL----IKELE------- 1580
K + ++ +V L + L ELE K+E + L +++L+
Sbjct: 1064 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1123
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR---ELQERDQEVKSQRE 1637
G + + V H EE+ +E QA + + +LE+ L + + + + + R+
Sbjct: 1124 GTQGAEEVLRAH-----EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRT--RQTKILEEDLEQIKLSLR- 1693
++ Q E L Q RD E+ +ER+ Q+LE + QT + + +LEQ+ LR
Sbjct: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1238
Query: 1694 ------ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL----RDKEKEVECQ-- 1741
G L R+ ++ S+A R L + +L R EK ECQ
Sbjct: 1239 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1298
Query: 1742 -QEHIHELQE-------LKDQLE-------------------QQLQGLHRKVGETSLLLS 1774
+++I+ +++ K QLE Q+ L E + L S
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1358
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Q + I ++++E E + + +L E + AL ++ Q EA Q + QA+ + +
Sbjct: 1359 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE-ELAVEGRRVQALEEVLGDLR 1893
++++ E+A + +++ +Q+ +Q R+ E E+ + R+ +A E R
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE------R 1472
Query: 1894 AESR-EQEKALLALQQQCAE-QAQEHEVETRALQDSWLQAQAVLKERDQELEALRA---- 1947
+ R E+E ++ LQ + E Q E E +AL+ +A+A ++ +E E LR
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1532
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKE---------QHLLEQAELSR------ 1992
ESQ R E +R +A EA + ALQ E + L QAE+ R
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1592
Query: 1993 SLEASTATLQASLDACQA----HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR- 2047
+LE + + +A L + +A + QLE +L QE + LR + + + QQA A+R
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAERRAQQQAEAERA 1650
Query: 2048 DEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ-----EREEEEIRGLHQSVRELQL 2101
EE + ER QL ++L R+Q + ++++L Q ++EE E + E Q
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ- 1709
Query: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
A +++E+ E +QR E + E L+ ++ + QR+L + A Q
Sbjct: 1710 --AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 2162 TEAREIEWREKAQDLALSLAQTKASVS-SLQEVAMFLQASVLERDSEQQRLQDEL----- 2215
EA +K Q+L LA+ +A + L A + S + +QRL+ E
Sbjct: 1768 REAAAA--TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825
Query: 2216 ---------ELTRRALEKERLHSPGATSTAELGSR--GEQGVQLGEVSGVEAEPSPDGME 2264
L A + +L A R E+ +GE + ++ E E
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885
Query: 2265 KQSWRQRLEHLQQAVA----RLEID----RSRLQRHNVQLRST-----------LEQVER 2305
K++ +RL L + A RLE ++ ++ QLR +E R
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1945
Query: 2306 ERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV-VLLQAQLT 2364
+RR+++ E + A S E + A + + GR + N++ ++ Q E+ Q QL
Sbjct: 1946 QRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
E ++++ Q S LA + A+ + E RRL E Q
Sbjct: 2004 AEEERRRREAEERVQKS--LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2057
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 282 bits (722), Expect = 2e-75
Identities = 421/1752 (24%), Positives = 739/1752 (42%), Gaps = 295/1752 (16%)
Query: 480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL 539
++L+ +++RR+ +L + ++EL L + E +L A + +
Sbjct: 207 DILQTPQFQMRRLKKQL--------ADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258
Query: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
L L E +S LE + L + + + + R +++ + LKTE + +
Sbjct: 259 DRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKIN 314
Query: 600 KLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA----RNALQVDLAEAEKRRE 655
+LS N L+ L QL++ + A Q + L+ +L+ A + ++
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKK 374
Query: 656 ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
L EKN L+ +L + EE ++LQ + QE+ E + L +QEAAT
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQLQDN--PPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
+A R E + Q++ L+ E+ E Q + DL + LS AKE LE +
Sbjct: 433 QA-RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE----Q 487
Query: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ 835
A Q + +L Q+ ++T + ++ EL + QA++++ A+ L Q
Sbjct: 488 ASQAHGA------RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541
Query: 836 AEQEGK------TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM 889
EQ + L E+++ ++ EK E R H Q+LA A E E E +
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDA 601
Query: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
LK+ +EA+ EKE+ + LE +LQ Q ++A+
Sbjct: 602 ALKQ----LEAL----------------------EKEKAAKLE-ILQQQLQVAN------ 628
Query: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009
E QT + +AQRE E +R+ + LQ + Q++ + Q
Sbjct: 629 --------------EARDSAQTSVTQAQREKAELSRKVEE----LQACVETARQEQHEAQ 670
Query: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL--TLSLMEKEQR 1067
QV +L+ QL R +Q+ EK R QE +++Q++L+ K SL T +E+E+R
Sbjct: 671 AQVAELELQL-------RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
Query: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127
+ AD++ +Q+ + + E + E + L Q + R+E++E+ A EA+L +
Sbjct: 724 ----RAADALEEQQ-----RCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
Query: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187
EA + LR L EA AAQ + E A ++ + Q +AQ +++
Sbjct: 775 GEAHQAETEVLRREL--AEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832
Query: 1188 ALQQALGSVCE-SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH 1246
L CE +R EL ++ V G+E + + ++ L L A +A AL
Sbjct: 833 EQLMTLKEECEKARQELQ---EAKEKVAGIE--SHSELQISRQQNELAELHAN-LARALQ 886
Query: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
++ + + Q+ L D + L+E++ T E +++ T L R+ + QE S+
Sbjct: 887 QVQEKEVRAQK----LADDLSTLQEKMAATSKEVARLET----LVRKAGEQQETASRELV 938
Query: 1307 KQNSLESELM-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
K+ + + E E Q +A LQ ME + E+ + ++E L+AA++
Sbjct: 939 KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ---------MGNELERLRAALM 989
Query: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN--- 1422
E++ Q EE + R +L E ++ + A + EL++ AL E
Sbjct: 990 ESQGQQQ-----EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
Query: 1423 LALLTQTLAE-------REEEVETLRG----QIQELEKQREMQKAALELLSLDLKKRNQE 1471
A L + LA +++E+ LRG QI+ELE+ R+ K E L+ K+
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
Query: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Q E E LE L V + EQ+ Q+EQ LE+ E +R
Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER-------ASR 1157
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
++D +E+ +GQ+++ A EL + + Q+ + + + A
Sbjct: 1158 AERDSALETLQGQLEEK----------AQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
Query: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
+ QE + ++S I LE ++L R++ E++ E K EL+R
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK-------ELKRL------ 1254
Query: 1652 DLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE 1711
+M + E+ Q LE++ ++L+ + ER L + Q ++E AE
Sbjct: 1255 --------VMAESEKSQKLEER----LRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
Query: 1712 EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSL 1771
+ QR + E+++ L + + E + + QE Q EQ L L + T
Sbjct: 1303 K-------QRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 1772 LLS----------QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
L+S Q + E +++ +E EQ + L+++L AQR L EL
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG----ELIP 1411
Query: 1822 LQQE--QQQAQGQEERVKEKADALQ-GALEQAHMTLKERHGELQDHKEQARR-LEEELAV 1877
L+Q+ +Q+ Q+ R ++ + A Q L++AH L E + L + R+ LE EL
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD- 1470
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937
QA E+ + +L A + E L +Q++ A+E EV T + + ++ VL+E
Sbjct: 1471 -----QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK---VLEE 1522
Query: 1938 RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997
R R QEE + A+ EQ + Q E ++ +E
Sbjct: 1523 RQ-------------RFQEERQKLTAQV---------------EQLEVFQREQTKQVEEL 1554
Query: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH---- 2053
+ L S A + ++L+ A++ Q GE Q + R Q + +LQ L+Q+++ H
Sbjct: 1555 SKKLADSDQASKVQQQKLK-AVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQ 1613
Query: 2054 -----------QQEREQLLE--KSLAQRVQEN--MIQEKQNLGQERE---------EEEI 2089
+Q+ ++L E +SL Q +EN + E + LG E + E+
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
Query: 2090 RGLHQSVRELQLTLAQKEQEILEL------------RETQQRNNLEALPHSHKTSPMEEQ 2137
R L VR L+ +A +Q++ +L RE Q + L+ S S E
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGT 1733
Query: 2138 SLKLDSLEPRLQ 2149
L + S PR Q
Sbjct: 1734 PLSITSKLPRTQ 1745
Score = 256 bits (654), Expect = 2e-67
Identities = 403/1782 (22%), Positives = 753/1782 (42%), Gaps = 259/1782 (14%)
Query: 237 RMDGREPAQLLLLLAKTQELE--------KEAHERSQELIQLKSQGDLEKAELQDRVTEL 288
R+ G E Q +L ++ L+ H S E + + +Q LE +EL+ + ++
Sbjct: 42 RIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECL-VSAQKVLEGSELE--LAKM 98
Query: 289 SALL----TQSQKQNEDYEKM-IKALRETVEILETNHTELMEHEASLSRNAQEEK-LSLQ 342
+ LL T S K D+E+ K E IL+ +++HE L+ N E L
Sbjct: 99 TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKF----VLDHEDGLNLNEDLENFLQKA 154
Query: 343 QVIKDITQVMVEEGDNIAQGSGHE-NSLELD--SSIFSQFDYQDADKALTLVRSVLTRRR 399
V + EE + + E LEL +S S ++ A + + T +
Sbjct: 155 PVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQF 214
Query: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
Q ++ L++QLA ++ ++ E E + R KL E+D Q +Q +D
Sbjct: 215 Q-MRRLKKQLA---------DERSNRDELELELAENR--KLLTEKDA---QIAMMQQRID 259
Query: 460 SLSKERE------LLQKAREELRQQLEVLEQEAWRLRRVNVELQL---QGDSAQGQKEEQ 510
L+ E L K EELR + E L + +L+ Q D Q E+
Sbjct: 260 RLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEE 319
Query: 511 QEELHLAVRE----RERLQEMLMGLEAKQSESLSELITLREALE---SSHLEGELLRQEQ 563
+L +RE ++LQ+ L L + S++ E + + LE S+ L+ + +E+
Sbjct: 320 NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379
Query: 564 TEVTAA-LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
E+ L++ E+ +++L + K EV L + L L+ L Q+ L
Sbjct: 380 NEILQGKLSQLEEHLSQLQDNPPQEKGEV------------LGDVLQLET--LKQEAATL 425
Query: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL 682
N + +R+E E R ++ L + H E + Q+ +LQ+ +
Sbjct: 426 AANNTQLQARVEMLETERG----------QQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475
Query: 683 RDIQEEKEEIQKKL----SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
++ + KEE+++ + Q + T++L L+ ++Q++ LA Q+ + ++
Sbjct: 476 SNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAK---EKQ 532
Query: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
A L LQ E+ Q L Q++ LSS+ + E L E ++ E T+ Q+ T
Sbjct: 533 AQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQ---EATRQDHAQQLATAA 589
Query: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
+ ER + +ERDAA +QL ALE++KAA + + Q
Sbjct: 590 E------------------EREASLRERDAALKQLE--------ALEKEKAAKLEILQQQ 623
Query: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQ 918
+ + R Q + +A +REK EL +++E Q +E A++E+ QA+ A +
Sbjct: 624 LQVANEARDSAQTSVTQA----QREKAELSRKVEELQACVET--ARQEQHEAQAQVAELE 677
Query: 919 MQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
+QL +E+++ + E + Q + +L +QL+ L++ +KV K +E L+E QR
Sbjct: 678 LQLRSEQQKATEKERVAQEKDQL---QEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Query: 979 ---ELKEAAR----QHRDDLAALQEESSSLLQDKMDLQK-------QVEDLKSQLVAQDD 1024
ELK R QH+ + L+EE + + LQ+ + E L+ +L
Sbjct: 735 CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
+Q E E ++ ++E + ++ ++E+A M +EQ + + +E + RQ+ A
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQY--GAMFQEQLMTLKEECEKARQELQEA 852
Query: 1085 LRQ----------DMQEAQGEQKELSAQMELLRQEVKEKE--ADFLAQEAQLLEELEAS- 1131
+ + Q E EL A + Q+V+EKE A LA + L+E A+
Sbjct: 853 KEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 1132 ------------HITEQQLRAS--LWAQEAKAAQLQ---------LRLRSTESQLEALAA 1168
EQQ AS L + A+A Q + ST++ L+A+
Sbjct: 913 SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
Query: 1169 E-QQPGNQAQAQAQLASLYSALQQALGSVCESRPE-------LSGGGDSAPSVWGLEPDQ 1220
E +Q GN+ L L +AL ++ G E R + L+ A + LE
Sbjct: 973 EAEQMGNE------LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAA 1026
Query: 1221 NGARSLFKRGPLLT-----ALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE---- 1271
+ + L A EA+A AL + + + R + Q+++LEE
Sbjct: 1027 RAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQT 1086
Query: 1272 --RLTDTEAEKSQVHTELQDLQRQLSQNQE----EKSKWEGKQNSLESELMELHETMASL 1325
+L + A+K + H Q + + E + + + LE + + E SL
Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Query: 1326 QSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR 1385
+ L R E E LQ E ++ H Q+A+ A+ + +A +D A
Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Query: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ 1445
K + E ER +L +L+E +++L + + E+E E + L+ +
Sbjct: 1207 DEWKAQVARGRQEAERKNSLIS----------SLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI-QELEKCRSVLEHLPMAVQEREQKLT 1504
++ + + L LL + + + + +E++ R E +A + Q+LT
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
Query: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELE- 1563
Q E+ EL ++ + + + + E+ ++ + Q L +L+ + L +L+
Sbjct: 1317 SQAERAEELGQELKAW----QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
Query: 1564 -----ENHHKMECQQKL-------IKELEGQRET-QRVALTHLTLDLEERSQELQAQSS- 1609
E H+ E +Q + L QRE + + L + E +Q+L+A+ +
Sbjct: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKAS 1432
Query: 1610 ---QIHDLESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHLTQDLE--RRDQELMLQ 1663
Q+ L+ +LA E + + R+ +E EL + +E Q+L R D E L
Sbjct: 1433 YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLA 1492
Query: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
+ +Q R+ +++ E K+ + E + +RQ + + E+ + + Q
Sbjct: 1493 E--VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550
Query: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
+E + L D ++ + QQ+ + +Q + +Q+ Q L ++ E LSQ+EQ
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843
+ Q+++A+ + K+ Q++QEL+ + +Q Q + + ++ +A+ L
Sbjct: 1611 KLQMEKAKTHYDAKK---------------QQNQELQEQLRSLEQLQKENKELRAEAERL 1655
Query: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
L+QA + KE + Q R LE ++A ++++ L
Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 238 bits (608), Expect = 4e-62
Identities = 366/1640 (22%), Positives = 696/1640 (42%), Gaps = 211/1640 (12%)
Query: 85 PQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVD 144
P+ WE E EL V L+ + L +N L ++KA V + E+L+
Sbjct: 113 PRDWEQFEYKIQAELAVILKFVLDHEDGL-NLNEDLENFLQKAPVPSTCSSTFPEELSPP 171
Query: 145 WSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA---TDRD 201
+A+ E+ E Q +L G + + F+ L+ + A ++RD
Sbjct: 172 SHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRD 231
Query: 202 LMELK-AEHVRL----SGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
+EL+ AE+ +L + R+ A E + + EP +L L K + L
Sbjct: 232 ELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPL---EPKELEELRDKNESL 288
Query: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
HE ++ LK+ EK+++ ++ +LS ++N D ++ ++ L
Sbjct: 289 TMRLHETLKQCQDLKT----EKSQMDRKINQLS-------EENGDLSFKLREFASHLQQL 337
Query: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ--VMVEEGDNIAQGSGHENSLELDSS 374
+ EL E + ++ E++ L++ + Q +EE + I QG + LE S
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK--LSQLEEHLS 395
Query: 375 IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434
Q+ + L V + T +++A L Q V +L+ + Q E + A R
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAAT-LAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE----ELRQQLEVLEQEAWRLR 490
++ E+ L+ DLQ + +LS+ +E L++A + L Q+ L E L
Sbjct: 455 GHFEE---EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE---LT 508
Query: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550
+N +Q Q G K++ +E+ + ++ ++ GL + + S L + L+
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
Query: 551 SSHLEGELLRQEQTEVTAALARAEQSI-----AELSSSENTLKTEVADLRAAAVKLSALN 605
+ E RQ+ + A A ++ A L E K + A L +L N
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN 628
Query: 606 EALALDKVGLNQ---QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR--------- 653
EA + + Q + +L + + + + +E A Q ++ Q +AE E +
Sbjct: 629 EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKAT 688
Query: 654 -REALWEKNTHLEAQLQKAEEAG-------------------------AELQADLRDIQE 687
+E + ++ L+ QLQ +E+ +EL+A+ R + E
Sbjct: 689 EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Query: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR-----------AVQEKEALVR 736
+ + +K+L E R ++ +L+QL + + + EVL R A E E LV+
Sbjct: 749 QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK 808
Query: 737 EKAALEVRLQAVERDRQDLA----EQLQGLSSAKELLESSLFEAQQQ------NSVIEVT 786
E AA R + +++ EQL L E L EA+++ +S ++++
Sbjct: 809 EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQIS 868
Query: 787 KGQ---LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
+ Q E+ ++V + EVR KL D S +++ A ++++A+ E + A
Sbjct: 869 RQQNELAELHANLARALQQVQEKEVRAQKLADDL--STLQEKMAATSKEVARLETLVRKA 926
Query: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAK-------ALESLEREKMELEMRLKEQQT 896
EQQ+ A + V + +++ W +++ + AL+++ERE ++ L+ +
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 897 EMEAIQAQREEERTQAESALC---------QMQLETEKERVSLLETLLQT--QKELADAS 945
+ Q Q++EER Q E + Q L EK + LE LQ ++ + +
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 946 QQLERLRQDMKVQKLKEQETT---GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
E L + ++ K+QE G+ Q++E + EL++ +Q ++ LA ++E +S
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE-ELRQTVKQLKEQLAKKEKEHASGS 1105
Query: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS------ 1056
+ + + E +L A +EQ+ Q ++ ++ + +++ LE E+AS
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ---KQQEQADSLERSLEAERASRAERDS 1162
Query: 1057 ----LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE------------AQGEQK--- 1097
L L EK Q L Q A + Q+EL+A R +Q+ A+G Q+
Sbjct: 1163 ALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222
Query: 1098 ------ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR---ASLWAQEAK 1148
L ++ +L ++V EKE + + ++ E E S E++LR A + A+
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
Query: 1149 AAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGD 1208
AA+ LR L A +Q+ ++ Q + A + LG ++ E +
Sbjct: 1283 AAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERA--EELGQELKAWQEKFFQKE 1340
Query: 1209 SAPSVWGLEPDQNGA--RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266
A S LE A L L L AE A+A + ++L +++Q LR ++
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQ-AAAEKRHREELEQSKQAAGGLRAEL 1399
Query: 1267 QK----------LEERLTDTEAEKSQVHTELQDLQRQLSQNQE------EKSKWEGKQNS 1310
+ L +++ + E Q+ E QLS ++ E+++ G++ +
Sbjct: 1400 LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ 1370
L + +E+ A + EL + A E L + +E AQ + V+ A+ +
Sbjct: 1460 LGRQFLEVELDQAREKYV---QELAAVRADAETRLAEVQRE---AQSTARELEVMTAKYE 1513
Query: 1371 ASAAGILEEDLR--TARSALKLKNEEVES-ERERAQALQEQGELKVAQG----KALQENL 1423
+ +LEE R R L + E++E +RE+ + ++E + K+A K Q+ L
Sbjct: 1514 GAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSK-KLADSDQASKVQQQKL 1572
Query: 1424 ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE 1483
+ E ++E + L+ Q+ EL+ Q ++ A E L ++K D +++Q QEL+
Sbjct: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 1484 KCRSVLEHLPMAVQEREQKLTVQREQI-RELE----KDRETQRNVLEHQLLELEKKDQMI 1538
+ LE L Q+ ++L + E++ EL+ K +E ++ H ++ + +
Sbjct: 1633 EQLRSLEQL----QKENKELRAEAERLGHELQQAGLKTKEAEQ-TCRHLTAQVRSLEAQV 1687
Query: 1539 ESQRGQVQDLKKQLVTLECL 1558
Q++DL K V + L
Sbjct: 1688 AHADQQLRDLGKFQVATDAL 1707
Score = 228 bits (582), Expect = 4e-59
Identities = 381/1669 (22%), Positives = 700/1669 (41%), Gaps = 234/1669 (14%)
Query: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873
EL QA++E Q + G L A+ ++ Q + + + L
Sbjct: 167 ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQ-------FQMRRL 219
Query: 874 AKALESLEREKMELEMRLKEQQ---TEMEAIQAQREEE--------RTQAESALCQMQLE 922
K L + ELE+ L E + TE +A A ++ QA S L +LE
Sbjct: 220 KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE 279
Query: 923 TEKER-VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
+++ SL L +T K+ D + E+ + D K+ +L E+ G L +L+E L+
Sbjct: 280 ELRDKNESLTMRLHETLKQCQDL--KTEKSQMDRKINQLSEEN--GDLSFKLREFASHLQ 335
Query: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQE--VQEKLRE 1039
Q +D L L EE S Q+ ++ Q Q+E K A D + L E+ +Q KL +
Sbjct: 336 ----QLQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGKLSQ 389
Query: 1040 TQEY-NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098
+E+ +++Q +EK + +++ L L+Q+ +
Sbjct: 390 LEEHLSQLQDNPPQEKGEVLGDVLQ------------------LETLKQEAATLAANNTQ 431
Query: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
L A++E+L E ++EA LA+ EE +QQL + + ++ + L
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEE-------KQQLSSLITDLQSSISNL------ 478
Query: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218
++++ E A Q G A+ AQ+ASL S L ++ + EL+G A E
Sbjct: 479 SQAKEELEQASQAHG--ARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAK-----EK 531
Query: 1219 DQNGARSLFKRGPLLTAL--SAEAVASALHKLHQDLWKTQQTRDVLR-DQVQKLEERLTD 1275
A++L ++ L E ++S+L + Q L + + ++ R D Q+L +
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
EA + L +QL ++EK+ K L+ +L +E S Q+ + +A+ +
Sbjct: 592 REASLRERDAAL----KQLEALEKEKA---AKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV 1395
+ E + E LQA E + QA V E Q + E+ T + + + +++
Sbjct: 645 KAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS----EQQKATEKERVAQEKDQL 700
Query: 1396 ESERERAQALQEQGELKVAQGK----------ALQENLALLTQTLAEREEEVETLRGQIQ 1445
+ E+ QAL+E LKV +G AL+E +++ AE VE + + +
Sbjct: 701 Q---EQLQALKES--LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505
ELE++R +K L + E ++ + ++ E + E ++ +++
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAES---ECEQLVKEVAA 812
Query: 1506 QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLA-LELEE 1564
RE+ + +++ + + QL+ L+++ E R ++Q+ K+++ +E + L++
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLKEE---CEKARQELQEAKEKVAGIESHSELQISR 869
Query: 1565 NHHKM-ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR 1623
+++ E L + L+ Q + + V L DL +++ A S ++ LE+ L R
Sbjct: 870 QQNELAELHANLARALQ-QVQEKEVRAQKLADDLSTLQEKMAATSKEVARLET----LVR 924
Query: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
+ E Q+ + RE ++E R + + + LE+Q+ RQ +
Sbjct: 925 KAGE--QQETASRELVKEPARAGDR-----------------QPEWLEEQQGRQFCSTQA 965
Query: 1684 DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE 1743
L+ ++ + G EL R + E +G + +RG E + + R ++ Q +
Sbjct: 966 ALQAMEREAEQMGNELERLRAALME----SQGQQQEERGQQE--REVARLTQERGRAQAD 1019
Query: 1744 HIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS 1803
E + + +LE +LQ L+++ E LQ+ L A + E K+Q
Sbjct: 1020 LALE-KAARAELEMRLQNA----------LNEQRVEFATLQEALAHALTEKEGKDQ---- 1064
Query: 1804 QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863
+L + + A + +ELE L+Q +Q + Q + +++ + GA +A + +L+
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
Query: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923
+ + +LE++ + + +LE L RA E++ AL LQ Q E+AQE
Sbjct: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG----- 1179
Query: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
+Q+ L +EL A R + Q E+ +A+ ++ + ++ + E+
Sbjct: 1180 ------HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
Query: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
+ E + L+ + A S++LEE LR+ + E R
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR----------- 1282
Query: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
A+R LR +E + L E++ QRV ++++ ER EE L Q ++ Q
Sbjct: 1283 AAERSSALR--EEVQSLREEAEKQRVASENLRQELTSQAERAEE----LGQELKAWQEKF 1336
Query: 2104 AQKEQEI--LELRETQ-QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE------- 2153
QKEQ + L+L T Q E LP H ++ + + E R + ELE
Sbjct: 1337 FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQA---AAEKRHREELEQSKQAAG 1393
Query: 2154 --RLQAALRQTEARE-IEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQR 2210
R + Q E E I R+K + + Q +A +S E L+ + E +
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRG 1453
Query: 2211 LQDELELTRRALEKERLHSPGATSTAELGS-RGEQGVQLGEVSGVEAEPSPDGMEKQSWR 2269
L + L R+ LE E L EL + R + +L EV E QS
Sbjct: 1454 LGERANLGRQFLEVE-LDQAREKYVQELAAVRADAETRLAEVQ----------REAQSTA 1502
Query: 2270 QRLEHL----QQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI 2325
+ LE + + A ++ +R R Q +L + +EQ+E +RE + + S ++
Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE----VFQREQTKQVEELSKKL 1558
Query: 2326 SKATASSPTQQDG----RGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381
+ + +S QQ + Q + LQ ++ LQAQL+ + + + Y +
Sbjct: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY-----KLQ 1613
Query: 2382 RELAGLHH--------SLSHSLLAVAQ-APEATVLEAETRRLDESLTQS 2421
E A H+ L L ++ Q E L AE RL L Q+
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Score = 81.3 bits (199), Expect = 1e-14
Identities = 164/756 (21%), Positives = 301/756 (39%), Gaps = 90/756 (11%)
Query: 9 NNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRS 68
N + Q ++ ++ LA E + KL+ + AQ ++ + +L+ V Q +
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE---LEELRQTVKQLKE 1092
Query: 69 WCQELEKRLEATGGPIPQRWENVEE--PNLDELLVRLEEEQQRCESLAEVNTQLRLHMEK 126
+ EK + G + E P L+ L + + +Q+C+ E L +E
Sbjct: 1093 QLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE- 1151
Query: 127 ADVVNKALRED-VEKLTVDWSRARDELMRKESQW---QMEQEFFKGYLKGEHGRLLSLWR 182
A+ ++A R+ +E L EL +S Q E F+ ++ +H + W+
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ-DHSKAEDEWK 1210
Query: 183 EVVTFRRHFLEMK----SATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
V R E K S+ + ++ L + + G L+ V A+S + S ++
Sbjct: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE--LKRLVMAESEK---SQKL 1265
Query: 239 DGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTE-LSALLTQSQK 297
+ R L LL A+T A ERS L + + Q E+AE Q +E L LT +
Sbjct: 1266 EER----LRLLQAETASNSARAAERSSALRE-EVQSLREEAEKQRVASENLRQELTSQAE 1320
Query: 298 QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV----MV 353
+ E+ + +KA +E + + E +LS Q E S Q ++ ++
Sbjct: 1321 RAEELGQELKAWQE----------KFFQKEQALS-TLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQ------DADKALTLVRSVLTRRRQAVQDLRQ 407
+ + A H LE + + + + L + V + R A Q LR
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA-QQLRA 1428
Query: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL 467
+ A E +++L++ H EE + L GER L Q ++++ + + K +
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGL--------GERANLGRQFLEVELD-QAREKYVQE 1479
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
L R + +L +++EA R EL++ +G K + EE ER++L
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTAR---ELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQ 1536
Query: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
+ LE Q E ++ L + L S ++ +Q+ V A ++Q L + N L
Sbjct: 1537 VEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNEL 1596
Query: 588 KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
+ +++ AA LQ+E+ + +A +Q LQ L
Sbjct: 1597 QAQLSQKEQAA-----------------EHYKLQMEKAK----THYDAKKQQNQELQEQL 1635
Query: 648 AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAAT 707
E+ L ++N L A+ AE G ELQ +E ++ + ++ R +
Sbjct: 1636 RSLEQ----LQKENKELRAE---AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
Query: 708 TQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
+QL K Q V A++ +E + + L +
Sbjct: 1689 HADQQLRDLGKFQ--VATDALKSREPQAKPQLDLSI 1722
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 265 bits (678), Expect = 3e-70
Identities = 544/2667 (20%), Positives = 1092/2667 (40%), Gaps = 394/2667 (14%)
Query: 55 LVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNL--DELLVRLEEEQQRCES 112
L+ +L+A+ + R+ ELE RL+ + + +E L ++ V L E+++
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
+ + ++A AL + ++KLT D S R + ++ +EQ+ K K
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA--ESARCSLEQKI-KEKEKE 395
Query: 173 EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232
L R T + ++MK+ ++L + K H L L +LT Q E
Sbjct: 396 FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD----KLTSVKQQLEN 451
Query: 233 NGSGRMDGREPAQLLLLLA--KTQELEKEAHERSQELIQLKSQGDLEKAE---LQDRVTE 287
N A+ + K EL + E +E LKS + + E L+ +
Sbjct: 452 NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511
Query: 288 LSALLTQSQK-------QNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
+ L QSQ +N E M++ L+E + E + T +E + ++++
Sbjct: 512 IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT--LEKLKLAVADLEKQRDC 569
Query: 341 LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400
Q ++K + + D +++ +L L + + +Y++ + TL + +
Sbjct: 570 SQDLLKKREHHIEQLNDKLSKTEKESKAL-LSALELKKKEYEELKEEKTLFSCWKSENEK 628
Query: 401 AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
+ + + Q +N L+ + + +R++ L +R+ L+ + +L +DS
Sbjct: 629 LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688
Query: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
S E E + A EL+Q+ E +Q+ ++ + L+ GQ E+ + +L L E
Sbjct: 689 KSVEVETQKLAYMELQQKAEFSDQKH---QKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745
Query: 521 RERLQEMLMGLEAKQSESLSELITLREA---LESSHLEGELLRQEQTEVTAALAR----- 572
L A+ ESL +L+ ++A H L +Q + + A
Sbjct: 746 IMDKDRCYQDLHAEY-ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804
Query: 573 ----AEQSIAELSSSENTLKTEVADLRAAAVKLSALN------------EALALDKVGLN 616
+E+S L + ++ + + R +++ S + E L K +
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
Query: 617 QQLLQLEEENQSVCS----RMEAAEQARNALQVDLAEA-------EKRREALWEKNTHLE 665
+ L++ E+ +QS + R+ ++ +A Q +AE EK + L +K +
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
A++Q+ +++ L+ L+++Q E + + E ++E+L QE +E+ A
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQL-----------QGLSSAKELLESSLF 774
QEK L+++ + + E+ +L++Q + +A E L
Sbjct: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044
Query: 775 EAQQQNSVIEVTKGQL----EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAA 830
AQ++NS +E + E + + Q KE E + E T+ + AE+
Sbjct: 1045 AAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ----EFLTKLAFAEERNQNLM 1100
Query: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQLREK---WEKERSWHQQELAKALESLEREKMEL 887
+L +Q ++ + + + E L+++ ++E++ Q+E+ L+ E+ +
Sbjct: 1101 LELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVM 1160
Query: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL---------LETLL--- 935
+ + + Q E E I+ +E ++ + Q++ E + +SL LE +L
Sbjct: 1161 KTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Query: 936 -----QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH--- 987
+++KE +L+ +R D++ L++ ++ I + E E K + H
Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280
Query: 988 --RDDLAALQ-------------EESSSLLQ-DKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
++D A LQ E+ +LQ +K +L ++ D +S+ + + R + +
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT---ATRKMAE 1337
Query: 1032 EVQEKLRETQEYNR----IQKELEREKASLTLSLMEKEQR---LLVLQEADSIRQQELSA 1084
EV + L E + N + EL + EQ L L E++S LS
Sbjct: 1338 EVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD 1397
Query: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITEQQLRAS 1141
M A+ ++K LS Q E + + ++ ++ ++L ++ L+A ++ +
Sbjct: 1398 KEVQMHFAELQEKFLSLQSE--HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455
Query: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
K QL L E + +L++ P + + + +S Y AL + G +
Sbjct: 1456 FQGDLVKEMQLGLE----EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDM----- 1506
Query: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
L + A S D+ SL + L+ + SA K ++L + +V
Sbjct: 1507 SLLSNLEGAVSANQCSVDEVFCSSLQEEN-----LTRKETPSAPAKGVEEL---ESLCEV 1558
Query: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK--------SKWEGKQNSLES 1313
R ++KLEE++ E++ + E+Q+L++ LS ++E S+ E Q L S
Sbjct: 1559 YRQSLEKLEEKM---ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTS 1615
Query: 1314 ELMELHETMA---------SLQSRLRRAELQRMEA--------------QGERELLQAAK 1350
+E+ +A SL+ + R +LQ ++ QG E +K
Sbjct: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISK 1675
Query: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLR--TARSALKLKNEEVESERERAQALQEQ 1408
E+ + E V A L D+ T A+K E E+ +
Sbjct: 1676 EHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVK-PTGECSGEQSPDTNYEPP 1734
Query: 1409 GELKVAQGKALQENL------ALLTQTLAEREEEVETLRGQIQEL------------EKQ 1450
GE K L AL+ +E++ L+ +++E ++
Sbjct: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD 1794
Query: 1451 REMQKAALELLSLDLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
R+++ E+ LD K QEV L E ELEK L+ + E+ + + +
Sbjct: 1795 RKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQ 1854
Query: 1509 QIR-------------ELEKDRETQRNVLEH----------QLLELEKKDQMIESQRGQV 1545
++ E+ D+ ++ ++ ++ + L++E + I S++ +
Sbjct: 1855 ELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASI 1914
Query: 1546 Q------DLKKQLVTLECLALELE-ENHHKM-ECQQKLIK-------ELEGQRET---QR 1587
+ + ++V E L LE + EN K+ C ++ + +L G+ +T +
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974
Query: 1588 VALTHLTLDLEERSQELQAQSSQ-IHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646
AL L+ ++E++QEL++ S+ +H ++ V E++E+ + +++ + EL + K
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQ----VAEAEVKEKTELLQTLSSDVSELLKDK 2030
Query: 1647 EHLT---QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE-LTTQ 1702
HL Q LE+ Q L L K ++ Q ++ ++L ++ E ++ L E E L
Sbjct: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
Query: 1703 RQLMQERAEEGKGPSKAQ---------RGSLEHMKLILRDKEKEVECQQEHIHELQELKD 1753
+ L E+G+ + R +E +++ + EK+ E + E + D
Sbjct: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813
L+ +++ L R+ L +S+ QE+V+L E + + ++L++Q++E R+L
Sbjct: 2151 SLKDKVENLERE-----LQMSEENQELVILDA------ENSKAEVETLKTQIEEMARSLK 2199
Query: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873
+ +L L+ E++ Q ++EK QG L + L L++ KEQA
Sbjct: 2200 VFELDLVTLRSEKENLTKQ---IQEK----QGQLSELDKLLSSFKSLLEE-KEQA----- 2246
Query: 1874 ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ--QCAEQAQEHEVETR-ALQDSWLQ 1930
E+ ++ A+E + L+ E E AL Q+ + EQ+ + +E L++S +
Sbjct: 2247 EIQIKEESKTAVEMLQNQLK-ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
+A L+ +++ + + + S H + + R E L+ L A ++H +AE
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART----NQEHAALEAEN 2361
Query: 1991 SRSLEASTATLQASLDACQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047
S+ TL+A ++ R LE +R ++ + ++ + QE + +L+ +
Sbjct: 2362 SKG---EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
Query: 2048 DEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL---QLTLA 2104
+ L QE+EQ ++VQ ++EK + E + +++ L++ V L Q
Sbjct: 2419 ENIL---QEKEQ-------EKVQ---MKEKSSTAMEMLQTQLKELNERVAALHNDQEACK 2465
Query: 2105 QKEQ------EILELRETQQRNNLEALPHSHKT---------SPMEEQSLKLDSLEPRLQ 2149
KEQ E LEL + Q L+ +++ +E+ KL+ + +
Sbjct: 2466 AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS 2525
Query: 2150 R------ELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE 2203
R + E+L + L Q E W+E+ +L + + + LQ LQ ++
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
Query: 2204 RDSEQQRLQDELELTR---------------RALEKERLHSPGATSTAELGSR------- 2241
S + L++ELELT+ + E +R A TAEL
Sbjct: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
Query: 2242 --GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHL------QQAVARLEIDRSRL---- 2289
GE + L E+ + + +E ++ L+ + ++ R EI +L
Sbjct: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHE 2705
Query: 2290 --QRHNVQLRSTLEQVERE----RRKL-KREAMRAAQAGSLEISKAT---------ASSP 2333
++H L T +Q E E R KL +E ++Q +++ K++ A++
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
Query: 2334 TQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSH 2393
++ + K + K V +L+KE Q ++ L K + +EL+ L +
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Query: 2394 SLLAVAQAPEATVLEAETRRLDESLTQ 2420
+ L E + L E+L +
Sbjct: 2826 QKTGTVMDTKVDELTTEIKELKETLEE 2852
Score = 241 bits (616), Expect = 5e-63
Identities = 541/2681 (20%), Positives = 1051/2681 (39%), Gaps = 433/2681 (16%)
Query: 14 QSLQLVLEEQVLALQQQMAENQAASWRKLKN-SQEAQQRQATLVRKLQAKVLQYRSWCQE 72
+S + LE+++ +++ E + R + QE Q +A L ++LQ + E
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
Query: 73 LEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK 132
L+K + Q+ EN NL+E +L +Q ++ +LR ME+ N
Sbjct: 439 LDKLTS-----VKQQLEN----NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENN 489
Query: 133 ALREDVEKLTVDWSRARDELMRKESQWQMEQEF---FKGYLKGEHGRLLSLWREVVTFRR 189
L+ E+ + EL + Q F K + L L ++
Sbjct: 490 LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN 549
Query: 190 HF-----------LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
LE + +DL++ + H+ L+ +
Sbjct: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS------------------KT 591
Query: 239 DGREPAQLLLLLAKTQELEKEAHERS------QELIQLKSQGDLEKAELQDRVTELSALL 292
+ A L L K +E E+ E++ E +L +Q + EK LQ ++ L L
Sbjct: 592 EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCL 651
Query: 293 TQSQKQNEDYEKMIKAL-----------RETVEILETNHTELMEHEASLSRNAQEEKLSL 341
Q ++ +Y + ++ L R +L++ E+ + + Q+ + S
Sbjct: 652 KTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711
Query: 342 QQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD--YQDADKALTLVRSVLTRR- 398
Q+ K+I + ++ Q E+ L+L S+ D YQD +R +L +
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Query: 399 ---------RQAVQDLRQQLAGCQEAVNLLQQQH-------------DQWEEEGKALRQR 436
++++ QQ A N++ +Q DQ + L+ R
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
Query: 437 LQKLTGERDTLAGQTVDLQ----------GEVD-SLSKERELLQKAREELRQQLEVLEQE 485
+ L ++ DLQ GE++ +L K ++ Q E Q++ L+++
Sbjct: 832 VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED 891
Query: 486 AWRLRRV-----------NVELQLQGDSAQGQKEEQQE---ELHL---AVRERERLQEML 528
+ V ELQL D + ++ E QE HL +++E + L E L
Sbjct: 892 TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETL 951
Query: 529 MGLEAKQSESLSELI------------TLREALESSHLEGELLRQEQTEVTAALARAEQS 576
LE K+ S+ L TL+E S + E L Q+ + E+S
Sbjct: 952 -SLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
Query: 577 IAELSS---------------SENTLKTEVADLRAAAVKLSAL----NEALALDKVGLNQ 617
I+ELS + N + +AA K S L NE +L + N+
Sbjct: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
Query: 618 QLLQLEE----ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEE 673
L QL+E E+Q +++ AE+ L ++L E ++AL + T + Q E
Sbjct: 1071 -LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLEL---ETVQQALRSEMT--DNQNNSKSE 1124
Query: 674 AGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733
AG L+ ++ ++EE+ ++QK++++ + E ++ H+ + E + +V+E+E+
Sbjct: 1125 AGG-LKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 734 --------------------------LVREKAAL---EVRLQAVERDRQDLAEQLQ---- 760
LV+ +A L E++LQ E++++ L +LQ
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 761 ----------------GLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT-------V 797
GL + E + S + L+ +QT +
Sbjct: 1244 DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL 1303
Query: 798 TQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
+ E++Q E L EL+ RS+ A ++ + E K + H + V
Sbjct: 1304 EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363
Query: 858 LR--EKWEKERSWHQQELAKALESLEREKM-----ELEMRLKEQQTEMEAIQAQRE---E 907
+ E E+ H LA ES E + E++M E Q + ++Q++ + +
Sbjct: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD 1423
Query: 908 ERTQAESALCQMQLETEK---ERVSLLETLLQTQKELADASQ------------------ 946
+ Q S + ++Q + E + L L Q +L Q
Sbjct: 1424 QHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD 1483
Query: 947 --QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
L L + L EQ L + L+ A +A Q ++ E S LQ+
Sbjct: 1484 SSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAV-----SANQ-----CSVDEVFCSSLQE 1533
Query: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
+ +K+ ++ V + +S V ++ EKL E E I K E ++ LS
Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSER- 1592
Query: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
QE D +R+Q LS + Q +QK S +E+ + EK+ Q QL
Sbjct: 1593 -------QELDCLRKQYLS------ENEQWQQKLTSVTLEMESKLAAEKK-----QTEQL 1634
Query: 1125 LEELEASHITEQQL----RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180
ELE + + Q L R+ L A Q + + + E+ P +
Sbjct: 1635 SLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQIC 1694
Query: 1181 QLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240
+ QQ L E E + PD N G T S+E
Sbjct: 1695 DKDA-----QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP----GEDKTQGSSEC 1745
Query: 1241 VASALHKLHQDLWKTQQTRDVLRDQ--VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298
++ L D L +Q + L+ R+ +T E ++ ++D R++
Sbjct: 1746 ISELSFSGPNAL----VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLL 1801
Query: 1299 EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
E + + K + E +LM E L+ + + + + + E + L +VE
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 1359 HLQA--AVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERA---------QALQE 1407
+ + +E A S+ + +++ + K + +VE+E R +AL
Sbjct: 1862 TSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
Query: 1408 QGELKVAQGKAL---------QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
+ +L+V Q + L Q+ + L + L+ E LRG++ + K+ AL
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT----TAL 1977
Query: 1459 ELLSLDLKKRNQEVDLQQEQI--------QELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
+ LS +K++ QE++ Q + E+++ +L+ L V E + T +E++
Sbjct: 1978 DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037
Query: 1511 RELEKDRET---QRNVLEHQLLELEKKDQMIESQRGQVQD---------------LKKQL 1552
+ LEKD + + LE+Q+ +L K+ +++ + +Q L+ L
Sbjct: 2038 QSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAAL 2097
Query: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH 1612
V AL L ++ ++ I++L + E H+ L+ER +E + ++
Sbjct: 2098 VEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE 2157
Query: 1613 DLE-------SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL-----ERRDQEL 1660
+LE + ++ + + EV++ + QIEE+ R + DL E+ +
Sbjct: 2158 NLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK 2217
Query: 1661 MLQKERIQVLE-DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
+Q+++ Q+ E D+ K L E+ EQ ++ ++E + T +++Q + +E A
Sbjct: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK---TAVEMLQNQLKELNEAVAA 2274
Query: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ-------LQGLHRKVGETSLL 1772
G E MK + + +E + + + +++L+ +LE LQ L LL
Sbjct: 2275 LCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLL 2334
Query: 1773 LSQREQEIVVLQQQLQEAR---EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA 1829
+ E L+++L+ AR E L+ ++ + +++ + + Q L L+ +
Sbjct: 2335 KGRVEN----LERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTI 2390
Query: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL 1889
+ ++E + + Q + + + LQ+ +++ +++E+ + +Q + L
Sbjct: 2391 RSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKEL 2450
Query: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRAL-------QDSWLQAQAVLKERDQEL 1942
+ A ++A A +Q + Q + E+E L +++++ Q+ + QE+
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510
Query: 1943 EALRAESQSSRHQEEAARARAEAL-QEALGKAHAALQG-----KEQHL------LEQAEL 1990
E + + + EE +R + + QE L + ++G KEQ+L +E +
Sbjct: 2511 ED--GKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQK 2568
Query: 1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQE----------GEIQDQDLRYQEDVQQL 2040
+ L++ A+LQ +L+ Q+ + LE L + + ++ ++ Q ++ ++
Sbjct: 2569 IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEM 2628
Query: 2041 QQALAQRDEELRHQQER-----EQLLEKSLAQRVQ------ENMIQEKQNLGQEREEEEI 2089
Q A+ EEL ++ R + LLE+ + + Q EN +K +++ E
Sbjct: 2629 AQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688
Query: 2090 RG-LHQSVRELQLTL--AQKEQEILELRETQQRNNLEALPHSHKTSPMEE----QSLKLD 2142
G + + + E QL L A+K+ + L L +T ++ +E + K + EE Q L++D
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQAL-LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 2143 SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202
L+ E L +L+ T E ++ D + Q K Q L S
Sbjct: 2748 LLKS----SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCK 2803
Query: 2203 ERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262
+ + E++ LQ EL + A EK++ + T EL + ++ + E EA+ D
Sbjct: 2804 QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDK 2863
Query: 2263 -----MEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317
+ + + E L+ VA L +S+ L + + + + +
Sbjct: 2864 YCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSS 2923
Query: 2318 AQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL 2358
Q + K SS ++GRG + + ++ K+ V+
Sbjct: 2924 GQ--NKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVM 2962
Score = 211 bits (536), Expect = 9e-54
Identities = 485/2301 (21%), Positives = 911/2301 (39%), Gaps = 412/2301 (17%)
Query: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
TR Q +Q+L QL ++ Q Q D E AL+++ QK+ E+ + +L+
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEA---ALQKQKQKVENEKT----EGTNLK 66
Query: 456 GEVDSLSKERELLQKAREEL---------------------RQQLEVLEQEAWRLRRVNV 494
E L + E L+K ++++ ++Q+E LEQE L+R
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE---LKRCKS 123
Query: 495 ELQLQGDSAQ---------------------------GQK-EEQQEELHLAVRERERLQE 526
EL+ +AQ G K E+ +E+ + V ER+RL+
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 527 MLMGLEAKQS-----------------ESLSELITLREALESSHLEGELLRQE-QTEVTA 568
+ L+AK++ ++ S + + ++ SHL R + + +A
Sbjct: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243
Query: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAV----------KLSALNEALALDKVGLNQQ 618
+ EQ E++ S +TL+ D ++ +L A N+ L L +
Sbjct: 244 SYFSGEQ---EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELR 300
Query: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
L E+E + ++ + + +V+L E EK ++ AQ +A L
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQ-LHQEAKRQEEVLARAVQEKEALVRE 737
+ L+ + E+ LS R E+A LEQ + ++ K +E L+R + + L +E
Sbjct: 361 EQKLKKLTED-------LSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
Query: 738 ----KAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
KA L LQ + L +L L+S K+ LE++L E +Q+ E +++
Sbjct: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473
Query: 794 IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
+ ++ E ++ E LK + ++++ +A + + Q + + E+ KA +
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSE-QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
Query: 854 EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913
+ LR+ EK +QQE + LE L+ +LE +Q+ + + +RE Q
Sbjct: 533 QETMLRDLQEK---INQQENSLTLEKLKLAVADLE----KQRDCSQDLLKKREHHIEQLN 585
Query: 914 SALCQMQLETEKERVSLLETLLQTQKELADASQQL----------ERLRQDMKVQKLKEQ 963
L +TEKE +LL L +KE + ++ E+L M+ +K Q
Sbjct: 586 DKLS----KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQ 641
Query: 964 ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
L+T L+ Q + E E +L D+ +L ++ +L + L
Sbjct: 642 SKINHLETCLKTQQIKSHE-----------YNERVRTLEMDRENLSVEIRNLHNVL---- 686
Query: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083
+ VE E Q+ L+ ME +Q+ + +D Q+E+
Sbjct: 687 -DSKSVEVETQK-----------------------LAYMELQQK---AEFSDQKHQKEIE 719
Query: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ------LLEELEASHITEQQ 1137
+ + G+ ++L +++LL E+ +K+ + A+ LL+ +AS +T +
Sbjct: 720 NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED 779
Query: 1138 LRASLWAQEAKAA-----------QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLY 1186
+ SL A + + A Q + +E +LE A+Q P N A Q ++ SL
Sbjct: 780 HQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLE---ADQSPKNSAILQNRVDSLE 836
Query: 1187 SALQQA------LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA 1240
+L+ L CE ++ G E ++N L K + + AE
Sbjct: 837 FSLESQKQMNSDLQKQCEELVQIKG-----------EIEEN----LMKAEQMHQSFVAE- 880
Query: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE 1300
+ + KL +D T ++V+ + + LE + + + +V TE ++Q N
Sbjct: 881 TSQRISKLQED---TSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLL 937
Query: 1301 KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG------------ERELLQA 1348
+ K+ L SE + L + S L + E++ + + E+ L
Sbjct: 938 EDSL--KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
Query: 1349 AKENLTAQVEHLQAAVVEARAQ-----------ASAAGILEEDLRTARSALKLKNEEVES 1397
E+ ++ + ++ E Q G EDL A + KN ++E
Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
Query: 1398 ERERAQAL-----QEQGELKVAQGKALQENLALLT-------QTLAEREEEVETLRGQIQ 1445
+L E +LK A K QE L L + E E + LR ++
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505
+ + + + L+ + LK +E + Q+++ +L + E L ++ + + +
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLK---EEQNKMQKEVNDLLQEN---EQLMKVMKTKHECQNL 1169
Query: 1506 QREQIRELEKDRETQRNVLEHQ-LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
+ E IR K+RE++RN + ++LE K+ ++S Q+ L+ L E L+L+E
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE---LKLQE 1226
Query: 1565 NHHKMECQQKLIKELEGQRETQRV---------ALTHLTLDLEERSQELQAQSSQIHDLE 1615
+ + EC Q ++ + G ET + L +D EE+ + S +
Sbjct: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
Query: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
+H L LQ ++ + E LQ +K L +L E + ++ +
Sbjct: 1287 AH---LQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL 1343
Query: 1676 RQTKILEEDLEQIKLSLRE--RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRD 1733
+ KIL +D + L E G E Q E+ P + S EH+ L
Sbjct: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQ---PNEQHPVSLAPLD-ESNSYEHLTL---- 1395
Query: 1734 KEKEVECQQEHIHELQELKDQLEQQLQGLH-------RKVGETSLLLSQREQEIVVLQQQ 1786
+KEV Q H ELQE L+ + + LH K+ E + + E +VL
Sbjct: 1396 SDKEV---QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN 1452
Query: 1787 LQEAREQGELKEQ----------------------SLQSQLDEA-QRALAQRDQELEALQ 1823
L+ QG+L ++ SL S D + RAL ++ ++ L
Sbjct: 1453 LRNF--QGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS 1510
Query: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG-------ELQD----HKEQARRLE 1872
+ + V E +L++ ++T KE EL+ +++ +LE
Sbjct: 1511 NLEGAVSANQCSVDE---VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE 1567
Query: 1873 EELAVEG----RRVQALEEVLGDLRAE----------------------SREQEKALLAL 1906
E++ +G + +Q LE++L R E + E E L A
Sbjct: 1568 EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAE 1627
Query: 1907 QQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAES--QSSRHQEEAA-RARA 1963
++Q + + E EV LQ L ++++L ++ R ES S H E R
Sbjct: 1628 KKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPK 1687
Query: 1964 EALQEALGK-AHAALQGKEQHLLEQAELSRSLEAS------TATLQASLDACQAHSRQLE 2016
+ + K A L + + E + + E S T D Q S +
Sbjct: 1688 HDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECIS 1747
Query: 2017 EALRIQEGEIQDQD-LRYQEDVQQLQQALAQRDEE---LRHQQEREQLLEKSLAQRVQE- 2071
E + D L QED+ LQ + + E L H E +SL ++E
Sbjct: 1748 ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKEL 1807
Query: 2072 ---NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK-------EQEILELRETQQRNN 2121
+QE Q + + E+ + +++ L++K QE+L+ ET + N
Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN 1867
Query: 2122 LEALPHSHKTS--PMEEQSLKL-DSLEPR---LQRELERLQAALRQTEAREIEWREKAQD 2175
+ H+ K+S + + K+ DS + R ++ EL R+ ++E IE +
Sbjct: 1868 SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRI-----RSEKASIEHEALYLE 1922
Query: 2176 LALSLAQT-----KASVSSLQEVAMFLQASVLERDSEQQRLQDELE-LTRRALEKERLHS 2229
L + QT + + Q+V + L+ + SE+ +L+ EL+ ++++ ++L
Sbjct: 1923 ADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
Query: 2230 PGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQS-----WRQRLEHLQQAVARLEI 2284
T EL S + + +V+ E + + ++ S + HLQ+ + LE
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
Query: 2285 DRSRLQRHNVQLRSTLEQVERERRKLKREA------MRAAQAGSLEISKATASSPTQQDG 2338
D L +L + + Q+ +E+ L +E+ + + L +SKA ++ ++
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE 2102
Query: 2339 RGQK-NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLH---HSLSHS 2394
+ +S + V +L++ + L+ ++ + K++ + + RE L +L
Sbjct: 2103 FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE 2162
Query: 2395 LLAVAQAPEATVLEAETRRLD 2415
L + E +L+AE + +
Sbjct: 2163 LQMSEENQELVILDAENSKAE 2183
Score = 204 bits (518), Expect = 1e-51
Identities = 385/1768 (21%), Positives = 723/1768 (40%), Gaps = 231/1768 (13%)
Query: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
W++ A LQK +E L+ L +++EK++ Q QL+ L
Sbjct: 8 WKEGLPTRA-LQKIQE----LEGQLDKLKKEKQQRQ--------------FQLDSLEAAL 48
Query: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
++Q++ + E L RE L +++E+ +Q ++ +LQ S E L +
Sbjct: 49 QKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK 108
Query: 778 QQNSVIEV----TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833
+Q +E K +LE + Q Q+ +V + T + ++ + L
Sbjct: 109 KQIEKLEQELKRCKSELE-RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL 167
Query: 834 AQ---AEQEGKTALEQQ-KAAHEKEVNQ-LREKWEKERSWHQQELAKALESLEREKMELE 888
+ E E + LE + KA K+ +Q L + R + + + ++ S ++EK
Sbjct: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227
Query: 889 MRLKEQQT----EMEAIQAQREEERTQAESAL------CQMQLETEKERVSLLETLLQTQ 938
+ Q+T + A E+E T + S L LL+ L
Sbjct: 228 LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287
Query: 939 KELADASQQLE-RLR---QDMKVQKLKEQETTGILQTQLQEAQRELKEAAR---QHRDDL 991
+EL + +LE RL+ ++MK Q K QE LQ QL++A+ EL E + + RD+L
Sbjct: 288 QELRNKINELELRLQGHEKEMKGQVNKFQE----LQLQLEKAKVELIEKEKVLNKCRDEL 343
Query: 992 ----AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
A + S+ + L+K EDL Q + ++ +EQ+++EK +E QE
Sbjct: 344 VRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE----- 398
Query: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELL- 1106
EL R++ S Q D Q + L Q++Q+A+ L A+++ L
Sbjct: 399 -ELSRQQRS--------------FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
Query: 1107 --RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
+Q+++ +F + + + +AS I E +LR S+ +E K E+ L
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM--EEMK----------KENNLL 491
Query: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
+EQ+ +A+L ++ L Q+ E + + + + Q +
Sbjct: 492 KSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL 551
Query: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
+L K + L + S QDL K ++ +++L ++L+ TE E +
Sbjct: 552 TLEKLKLAVADLEKQRDCS------QDLLKKRE------HHIEQLNDKLSKTEKESKALL 599
Query: 1285 TELQDLQRQLSQNQEEK---SKWEGKQNSL----ESELMELHETMASLQSRLRRAELQRM 1337
+ L+ +++ + +EEK S W+ + L ESE L + L++ L+ +++
Sbjct: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
Query: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
E L+ +ENL+ ++ +L + L K+ EVE+
Sbjct: 660 EYNERVRTLEMDRENLSVEIRNL------------------------HNVLDSKSVEVET 695
Query: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE----TLRGQIQELEKQREM 1453
++ LQ++ E + + EN+ L T L + E++E L +I + ++ +
Sbjct: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
Query: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKC--RSVLEHLPMAVQEREQKLTVQREQIR 1511
A E L LK ++ + ++ + L + + H + + + +R + R
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815
Query: 1512 ELEKDRETQRN-VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
LE D+ + + +L++++ LE +ESQ+ DL+KQ L + E+EEN K E
Sbjct: 816 -LEADQSPKNSAILQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
Query: 1571 -CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD 1629
Q + E +QR++ E+ S + + LE+ +ELQ +
Sbjct: 872 QMHQSFVAE-----TSQRISKLQ-----EDTSAHQNVVAETLSALENKE----KELQLLN 917
Query: 1630 QEVKSQREQIEELQRQKEHLTQD----LERRDQELMLQKERIQVLEDQRTRQTKILEED- 1684
+V++++ +I+EL ++ HL +D L+ + L L+K+ + + R+ + L ++
Sbjct: 918 DKVETEQAEIQEL-KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 1685 --LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742
L++I SL + L + + +E + + KLIL + +E
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 1743 EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
E + + + + +L+ L + E + L R+ E+ +QL+EA + + Q
Sbjct: 1037 EDLSQKYKAAQEKNSKLECL---LNECTSLCENRKNEL----EQLKEAFAK---EHQEFL 1086
Query: 1803 SQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ 1862
++L A+ ELE +QQ +++ + + K++A G L+Q MTLKE ++Q
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQ-ALRSEMTDNQNNSKSEA--GGLKQEIMTLKEEQNKMQ 1143
Query: 1863 DHKEQARRLEEEL---AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
+ E+L Q LE + RE E+ + Q + +E +
Sbjct: 1144 KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 1920 ETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
++ Q L+A + L+E ++E E L+ E Q+ R E + + QE G
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263
Query: 1975 AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG-------EIQ 2027
+ +E+++ ELS S + A LQ SL +LE+ I + E+
Sbjct: 1264 CEIDAEEKYISGPHELSTS-QNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
Query: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN------LG 2081
D +++ + + + E++ + LL L + + E+ N L
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
Query: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141
E L S +E+Q+ A+ +++ L L Q + + H +S M E +
Sbjct: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSL---QSEHKILHDQHCQMSSKMSELQTYV 1439
Query: 2142 DSLEPR---LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ 2198
DSL+ L L Q L + +E L+ S +S+SSL + + +
Sbjct: 1440 DSLKAENLVLSTNLRNFQGDLVKEMQLGLE-EGLVPSLSSSCVPDSSSLSSLGDSSFY-- 1496
Query: 2199 ASVLERDSEQQRLQ-------------DEL---ELTRRALEKERLHSPGATSTAELGSRG 2242
++LE+ + L DE+ L L ++ S A EL S
Sbjct: 1497 RALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLC 1556
Query: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID--RSRLQRHNVQLRSTL 2300
E V + +E + G+ K Q LE L + R E+D R + N Q + L
Sbjct: 1557 E--VYRQSLEKLEEKMESQGIMKNKEIQELEQLLSS-ERQELDCLRKQYLSENEQWQQKL 1613
Query: 2301 EQVERERRKLKREAMRAAQAGSLEISKA 2328
V E + + SLE+ A
Sbjct: 1614 TSVTLEMESKLAAEKKQTEQLSLELEVA 1641
Score = 195 bits (496), Expect = 4e-49
Identities = 519/2603 (19%), Positives = 996/2603 (38%), Gaps = 512/2603 (19%)
Query: 71 QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVV 130
QELE +L+ QR + LD L L++++Q+ E+ T L+
Sbjct: 21 QELEGQLDKLKKEKQQR-----QFQLDSLEAALQKQKQKVENEKTEGTNLKRE------- 68
Query: 131 NKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRH 190
N+ L E E L + EL KESQ ++ G+L S +++ +
Sbjct: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQE-----------GQLNSGKKQIEKLEQE 117
Query: 191 FLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLL 250
KS +R ++ V L+ + T S+ +GS D +E
Sbjct: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE-------- 169
Query: 251 AKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310
+ KE ER + L+ V L A K
Sbjct: 170 ----KYNKEVEERKR---------------LEAEVKALQA----------------KKAS 194
Query: 311 ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
+T+ NH ++ H+AS S S QQ E+ + + +
Sbjct: 195 QTLPQATMNHRDIARHQASSS------VFSWQQ----------EKTPSHLSSNSQRTPIR 238
Query: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG 430
D S Y ++ +T RS L ++ D + +LL DQ + +
Sbjct: 239 RDFSA----SYFSGEQEVTPSRSTLQIGKR---DANSSFFDNSSSPHLL----DQLKAQN 287
Query: 431 KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490
+ LR ++ +L L G +++G+V+ + + L+KA+ EL ++ +VL + L
Sbjct: 288 QELRNKINELELR---LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELV 344
Query: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550
R + +++ ++ +R+ + LE K E E +E L
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF---QEELS 401
Query: 551 SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610
+ L QE ++ A L Q + + + N L+ E L
Sbjct: 402 RQQRSFQTLDQECIQMKARLT---QELQQAKNMHNVLQAE-------------------L 439
Query: 611 DKVGLNQQLLQ--LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
DK+ +Q L+ LEE Q +C AEQA A Q+ E + E + ++N L++
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCR----AEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE-----EV 723
++ L+A+L++I++ + Q E + + + T L L ++ +QE E
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL-------QGLSSAKELLESSLFEA 776
L AV + E +++ + L+ E + L ++L + L SA EL + E
Sbjct: 556 LKLAVADLE---KQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL 612
Query: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR----CLK---------------LELDT 817
+++ ++ K + E + + KE +Q ++ CLK LE+D
Sbjct: 613 KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 672
Query: 818 ERSQAE----------QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
E E + + ++LA E + K QK H+KE+ + K + +
Sbjct: 673 ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK--HQKEIENMCLK-TSQLT 729
Query: 868 WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ------------------------- 902
++L L+ L E M+ + ++ E E+++
Sbjct: 730 GQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ 789
Query: 903 -------------------AQREEERTQAE-----SALCQ-------MQLETEKERVSLL 931
++R E R +A+ SA+ Q LE++K+ S L
Sbjct: 790 QPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDL 849
Query: 932 ----ETLLQTQKEL---------------ADASQQLERLRQDMKVQKLKEQETTGILQTQ 972
E L+Q + E+ A+ SQ++ +L++D + ET L+ +
Sbjct: 850 QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909
Query: 973 LQEAQ-------------RELKEAARQHRDDLAALQEESSSLLQDKMDL-------QKQV 1012
+E Q +ELK++ D L LQ S +L +K ++ ++++
Sbjct: 910 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 1013 EDLKSQLVAQDDSQRLVEQEVQEKLRETQEY-NRIQKELEREKASLTLSLMEKEQRLLVL 1071
E+L + + + QE +++++ + N I EREK+ LS K+++L++L
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYID---EREKSISELSDQYKQEKLILL 1026
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Q R +E +D+ + +E ++++E L E + + QL E
Sbjct: 1027 Q-----RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKE 1081
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA------QLASL 1185
H Q+ L E + L L L + + L + + Q ++++A L
Sbjct: 1082 H---QEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE 1138
Query: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGL--EPDQNGAR---SLFKRGPLLTALSAEA 1240
+ +Q+ + + + +L + L EP +N + S + + E
Sbjct: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEV 1198
Query: 1241 VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT--------ELQDLQR 1292
+L + L Q +LR++ KL+E + E + ++ T LQD+Q
Sbjct: 1199 KEISLDSYNAQL---VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255
Query: 1293 Q-LSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE 1351
Q +S ++ + E K S EL A LQ L+ + E + E+LQA K
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315
Query: 1352 NLTAQVEHLQAAVVEA-RAQASAAGILEEDLRTARSALKLKNEEVESE---RERAQALQE 1407
L ++ ++ + A R A G L +++ L + E+ + E + E
Sbjct: 1316 ELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375
Query: 1408 QGELKVA-------------QGKALQENLALLTQTLAEREEEVETLRGQ-IQELEKQREM 1453
Q + +A K +Q + A L + + E + L Q Q K E+
Sbjct: 1376 QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSEL 1435
Query: 1454 Q----KAALELLSLDLKKRNQEVDLQQEQIQELEK---------C--------------- 1485
Q E L L RN + DL +E LE+ C
Sbjct: 1436 QTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSF 1495
Query: 1486 ----------RSVLEHLPMAVQEREQKL------TVQREQIRELEKDRETQRNVLEHQLL 1529
S+L +L AV + + ++Q E + E + V E + L
Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555
Query: 1530 ------ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR 1583
LEK ++ +ESQ G +++ K++ LE L L +++C L K+ +
Sbjct: 1556 CEVYRQSLEKLEEKMESQ-GIMKN--KEIQELEQL---LSSERQELDC---LRKQYLSEN 1606
Query: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ-------- 1635
E + LT +TL++E + L A+ Q L V +LQ D +S
Sbjct: 1607 EQWQQKLTSVTLEMESK---LAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDA 1663
Query: 1636 -REQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRE 1694
+ + E KEH ++ ER K + + D+ +Q L D+E+I E
Sbjct: 1664 IQGRNESCDISKEHTSETTER------TPKHDVHQICDKDAQQD--LNLDIEKI----TE 1711
Query: 1695 RGRELTTQRQLMQERAE---EGKGPSKAQRGSLEHMKLILRDKEKEVEC----QQEHIHE 1747
G T ++ + E G K Q S +L V QE IH
Sbjct: 1712 TGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN 1771
Query: 1748 LQ-ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
LQ +K+ + L+ LH ++ R++++ L +++E + L+E L ++++
Sbjct: 1772 LQLRVKETSNENLRLLH--------VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE 1823
Query: 1807 ---EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863
E ++ + + +E L ++ + + + ++ + +G M H +
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM-----HADKSS 1878
Query: 1864 HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA 1923
++ + + R +E L +R+E E L L+ + + E
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLE----ADLEVVQTEKLC 1934
Query: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
L+ Q V+ ++EL + +E R + + + AL + K Q E H
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Query: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
Q+E ++ + A ++ + Q S + E L+ + +Q++ ++D Q L
Sbjct: 1995 ---QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLK-DKTHLQEKLQSLEKDSQALSLT 2050
Query: 2044 LAQRDEELRHQQEREQLLEK---SLAQRVQENMIQEKQNLGQERE--------------- 2085
+ + ++ + ++LL K SL R+ E+ EK N+ + E
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSES-DYEKLNVSKALEAALVEKGEFALRLSS 2109
Query: 2086 -EEEIRGLHQSVRELQLTLAQKEQEIL----ELRETQQRNN-----LEALPHSHKTSPME 2135
+EE+ L + + +L++ + E++ L +L+E ++ N+ +E L + S
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN 2169
Query: 2136 EQSLKLDSLEPR-----LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
++ + LD+ + L+ ++E + +L+ E + R + ++L + + + +S L
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 2191 QEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE 2250
++ ++ + E++ + ++++E + L+ + + A G+Q +
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE----LNEAVAALCGDQEI---- 2281
Query: 2251 VSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR----------LQRHNVQLRSTL 2300
+ E P E+ R +E L+ ARLE D + + H L+ +
Sbjct: 2282 MKATEQSLDPPIEEEHQLRNSIEKLR---ARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
Query: 2301 EQVERE----RRKLKREAMRAAQA-GSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
E +ERE R + A+ A + G +E KA TQ + L+ +
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS------------LRGLELD 2386
Query: 2356 VVLLQAQ---LTLERKQKQDYIT 2375
VV ++++ LT E +++Q+ I+
Sbjct: 2387 VVTIRSEKENLTNELQKEQERIS 2409
Score = 179 bits (453), Expect = 4e-44
Identities = 335/1747 (19%), Positives = 717/1747 (41%), Gaps = 250/1747 (14%)
Query: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681
LEE + + +R A Q L+ L + +K ++ + LEA LQK ++ + +
Sbjct: 5 LEEWKEGLPTR---ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE 61
Query: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
+++ E + + + ++ + +L+ + QE L ++ E L +E
Sbjct: 62 GTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRC 121
Query: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ------------QQNSVIEVTKGQ 789
+ L+ ++ Q L ++ +++ + L +Q + N +E K +
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK-R 180
Query: 790 LEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ-----ERDAAARQLAQAEQEGKTAL 844
LE +++ + QAK+ Q + D R QA +++ L+ Q +T +
Sbjct: 181 LEAEVKAL-QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ--RTPI 237
Query: 845 EQQKAAH----EKEVNQLREK------------WEKERSWHQQELAKALESLEREKM-EL 887
+ +A E+EV R ++ S H + KA R K+ EL
Sbjct: 238 RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Query: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS-- 945
E+RL+ + EM+ + +E + Q E A ++ +E EK + L++T + AS
Sbjct: 298 ELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL-IEKEKVLNKCRDELVRTTAQYDQASTK 356
Query: 946 -----QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS 1000
Q+L++L +D+ Q+ + L+ +++E ++E +E + + L +E
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ 416
Query: 1001 LLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE-TQEYNRIQK-----ELEREK 1054
+ +Q +++ + L A+ D V+Q+++ L E Q+ R ++ +++ +
Sbjct: 417 MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
Query: 1055 ASLTLSLMEKEQRLLVLQEADSIR-----QQELSALRQDMQEAQGEQKELSAQ------- 1102
++ M+KE LL R + EL ++Q + ++Q +E+ A+
Sbjct: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 1103 MELLRQEVKEKEADFLAQEAQL-LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
+ L++++ ++E ++ +L + +LE Q L L +E QL +L TE
Sbjct: 537 LRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL---LKKREHHIEQLNDKLSKTEK 593
Query: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221
+ +A L SAL+ E + E + S W E ++
Sbjct: 594 ESKA-------------------LLSALELKKKEYEELKEE-----KTLFSCWKSENEK- 628
Query: 1222 GARSLFKRGPLLTALSAEA--VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279
LLT + +E + S ++ L L KTQQ + + ER+ E +
Sbjct: 629 ----------LLTQMESEKENLQSKINHLETCL-KTQQIKS------HEYNERVRTLEMD 671
Query: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEA 1339
+ + E+++L N L+S+ +E+ + ++AE +
Sbjct: 672 RENLSVEIRNL-----------------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
Query: 1340 QGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED---------LRTARSALKL 1390
Q E E + LT QVE L E + Q + I+++D + R LK
Sbjct: 715 QKEIENMCLKTSQLTGQVEDL-----EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
K+ + + + ++L L Q A+ + A + E R + + K
Sbjct: 770 KDASLVTNEDHQRSL-----LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824
Query: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ- 1509
+ + ++ L L+ + Q Q+Q +EL + + +E M ++ Q + Q
Sbjct: 825 SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 1510 IRELEKDRETQRNVLEHQLLELEKKDQ-------MIESQRGQVQDLKKQLVTLECLALEL 1562
I +L++D +NV+ L LE K++ +E+++ ++Q+LKK LE EL
Sbjct: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL 944
Query: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
+ + ++K + + + + LT L+E + L + +L S A
Sbjct: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKM---NLIQKSESFA 1001
Query: 1623 RELQERDQEVKSQREQIEE-----LQRQKE--HLTQDLERRDQELMLQKERIQVLEDQRT 1675
+ ER++ + +Q ++ LQR +E + +DL ++ + + +++ L ++ T
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
Query: 1676 RQTKILEEDLEQIKLSL--------------RERGR----ELTTQRQLMQERAEEGKGPS 1717
+ + +LEQ+K + ER + EL T +Q ++ + + S
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
Query: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH--RKVGETSLLLSQ 1775
K++ G L+ + L++++ ++ Q+ +++L + +QL + ++ H + + + S
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKM---QKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178
Query: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
+E+E + + + ++ + + LD L Q + L + + Q+++ ++E
Sbjct: 1179 KERE-----SERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC 1233
Query: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
++ + ++G LE +++ + E+ K+ EE+ + + L+
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQ-EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 1896 SREQEKALLALQQQC-AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
+ L L++ C QA+++E+ T L DS +++ + R E + ++
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTE-LNDS--RSECITATRKMAEEVGKLLNEVKIL 1349
Query: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
+++ E +++ G Q EQH + A L S TL S Q H +
Sbjct: 1350 NDDSGLLHGELVEDIPG-GEFGEQPNEQHPVSLAPLDESNSYEHLTL--SDKEVQMHFAE 1406
Query: 2015 LEE---ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE-------LRHQQ-----EREQ 2059
L+E +L+ + + DQ + + +LQ + E LR+ Q E +
Sbjct: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
Query: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLT----------------- 2102
LE+ L + + + + +L + R L + ++ L
Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
Query: 2103 -LAQKEQEILELRETQQR-----NNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQ 2156
+ ++E L +ET LE+L ++ S +E+ K++S +E++ L+
Sbjct: 1527 FCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS-LEKLEEKMESQGIMKNKEIQELE 1585
Query: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216
L +E +E++ K L++ + L V + +++ + + ++L ELE
Sbjct: 1586 QLL-SSERQELDCLRKQY-----LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELE 1639
Query: 2217 LTRRALE 2223
+ R L+
Sbjct: 1640 VARLQLQ 1646
Score = 124 bits (312), Expect = 9e-28
Identities = 207/1003 (20%), Positives = 412/1003 (41%), Gaps = 110/1003 (10%)
Query: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
E LP ++ Q+L Q +++++ ++ R+ Q + LE L+K+ Q +E+++ + +LK
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNLK 66
Query: 1550 KQLVTLECLALELEEN----HHKMECQQKLIKELEGQRETQRVALTHLTLDLE------E 1599
++ L + LE+ H+++ ++ + EGQ + + + L +L+ E
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE 126
Query: 1600 RSQE-LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
RSQ+ Q+ ++ + + L S+ E ++E ++ + LE +
Sbjct: 127 RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK 186
Query: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER--------GRELTTQRQLMQERA 1710
L +K Q L I S ++ + T R+
Sbjct: 187 ALQAKKAS-QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
Query: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
G+ R +L+ K RD H L DQL+ Q Q L K+ E
Sbjct: 246 FSGEQEVTPSRSTLQIGK---RDANSSFFDNSSSPH----LLDQLKAQNQELRNKINELE 298
Query: 1771 LLLSQREQEI-------VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELE 1820
L L E+E+ LQ QL++A+ + KE+ L DE R AQ DQ +
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR----LEEE-L 1875
AL+Q+ ++ ++ A++ + +LEQ +KE+ E Q+ + +R L++E +
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQ---KIKEKEKEFQEELSRQQRSFQTLDQECI 415
Query: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
++ R Q L++ E +K L +++QQ +E + + + ++ +Q
Sbjct: 416 QMKARLTQELQQAKNMHNVLQAELDK-LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE 474
Query: 1936 KERDQELEALRAESQSSR-HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
E + +E ++ E+ + H E+ AR + A L+ +Q L + + +
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQKAR--------EVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
+A + + L Q Q E +L +++ ++ DL Q D Q L +R+ +
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS--QDLLKKREHHIEQL 584
Query: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
++ EK ++ + + +K+ + +EE+ + +S E LT + E+E L+ +
Sbjct: 585 NDKLSKTEKE-SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Query: 2115 --------ETQQRNNLEALPHSHKTSPMEEQSLK---------LDSLEPRLQRELERLQA 2157
+TQQ + E +T M+ ++L LDS ++ +
Sbjct: 644 INHLETCLKTQQIKSHE-YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702
Query: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
++ E + + +++ +++ L +Q V L+ L ++++D Q L E E
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYES 762
Query: 2218 TRRALE-KERLHSPGATSTAELGSRGEQGVQ-------LGEVSGVEAEPSPDGMEKQSWR 2269
R L+ K+ L + +Q +GE + +E S +E
Sbjct: 763 LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822
Query: 2270 QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKAT 2329
+ LQ V LE ++ N L+ E++ + + +++ M+A Q +++ +
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
Query: 2330 AS-SPTQQDGRGQKNSDAKCVAEL---QKEVVLLQAQLTLERKQKQDYITRSAQTSRELA 2385
S Q+D +N A+ ++ L +KE+ LL ++ E+ + Q EL
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ-----------ELK 931
Query: 2386 GLHHSLSHSLLAVAQAPEATVLEAE--------TRRLDESLTQ 2420
+H L SL + E LE + +R E LTQ
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQ 974
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 262 bits (669), Expect = 3e-69
Identities = 419/2083 (20%), Positives = 887/2083 (42%), Gaps = 369/2083 (17%)
Query: 458 VDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517
V+ +S + LL++ R+E+ + LE+ + R AQ +++Q +L
Sbjct: 335 VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETR------------AQAMEKDQLAQL--- 379
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSI 577
+ E++ LQ++ Q+E + L + S L+ EL + + VT L + +
Sbjct: 380 LEEKDLLQKV-------QNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432
Query: 578 AELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAE 637
+ + + T + K+ +N L E ++SVCS +
Sbjct: 433 NSNYADQFNIPTNITT---------------KTHKLSINL----LREIDESVCSESDVFS 473
Query: 638 QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLS 697
+ L +E E ++E++L L D ++ EKEE++ KL
Sbjct: 474 NTLDTL----SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLK 529
Query: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
E E E L ++ K+ +E+ L+ E + L+ ++ E QDL
Sbjct: 530 EKNDLDE-----FEALERKTKKDQEM---------QLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
+L SS ELL + ++ I+ K LE ++ + E I+ + + D
Sbjct: 576 EL---SSKVELLREKEDQIKKLQEYIDSQK--LENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
E + +R++A + E + K KE+ ++ E + +Q +L
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKM----------KELATTYKQMENDIQLYQSQL---- 676
Query: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
E+ ++ +++LE L+ E+ + + + + + LC ++LE + +
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDLLCNLELEGK---------ITDL 725
Query: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
QKEL ++ E LR+++ + L E ++ L ++++ ++E+++ + ++L + E
Sbjct: 726 QKELNKEVEENEALREEVIL--LSELKS---LPSEVERLRKEIQDKS----EELHIITSE 776
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
L + + + +V+ L ++ D + + +E Q + +
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH---------- 826
Query: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
M+ EQ+ ++ E + QE+ L ++ Q+ L ++ QE++EK +
Sbjct: 827 ----MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882
Query: 1118 ---LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
L + QL E+LE T Q + E + + +L+ T +++ L E+
Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTV-------EREKTLITEKLQQTLEEVKTLTQEKDDLK 935
Query: 1175 QAQAQAQLA--SLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232
Q Q Q+ L S + + +++ +L +N SL +
Sbjct: 936 QLQESLQIERDQLKSDIHDTVNMNIDTQEQL----------------RNALESLKQHQET 979
Query: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT------E 1286
+ L ++ LH + T +T+D + ++ ++++ D EA+ +Q T E
Sbjct: 980 INTLKSKISEEVSRNLHMEE-NTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVKDNE 1037
Query: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346
+ + QR++ +EK++ Q LES + E + L
Sbjct: 1038 IIEQQRKIFSLIQEKNEL---QQMLESVIAEKEQLKTDL--------------------- 1073
Query: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQ 1406
KEN+ +E+ +E+LR LK + E V E+ A ++
Sbjct: 1074 ---KENIEMTIEN------------------QEELRLLGDELKKQQEIVAQEKNHA--IK 1110
Query: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQEL-EKQREMQKAALELLSLDL 1465
++GEL + LA + + L E+ ++++ + Q+ + E+ EMQK E+ +L
Sbjct: 1111 KEGELS-----RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
Query: 1466 KKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE 1525
+ +N+E+ L+ + + LE + + E+ E + +T +R+ ++EL+K ET+R+ L
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENY-----EEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 1526 HQLLELE------------------KKDQMIESQRGQVQDLKKQLVTLECLALELEENHH 1567
+ E+E + + I+ R V + Q++ + +LE++H
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ----DLEKSHT 1276
Query: 1568 KMECQ-------QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
K++ + Q+L+ ++ ETQ + L L E+ + + S+ + +E
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQET-MNELELLTEQSTTK---DSTTLARIEMERLR 1332
Query: 1621 LARELQERDQEVKSQREQIEELQ-----------RQKEHLTQDLERRDQELMLQKERIQV 1669
L + QE +E+KS ++ + L+ + KEH+ + L + QE ++E+
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI-QESQSKQEQSLN 1391
Query: 1670 LEDQRTRQTKILEEDLEQIK---LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
++++ TKI+ E +EQ K +L E+ + +QE +E K +K ++ L+
Sbjct: 1392 MKEKDNETTKIVSE-MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK-EKDDLQR 1449
Query: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH-------RKVGETSLLLSQREQE 1779
++ +L+ + +++ E+I E+ + E++L+ H + E + LS++E E
Sbjct: 1450 LQEVLQSESDQLK---ENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 1780 IVVLQQQLQ--------EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
I +Q+QL+ + +E E +EQ Q+ E Q + + Q E + + Q
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS 1566
Query: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD 1891
E ++ E + LQ + E+ + +KE KE+ +R++E L +E +++ + +
Sbjct: 1567 IESKMLELTNRLQESQEEIQIMIKE--------KEEMKRVQEALQIERDQLKENTKEIVA 1618
Query: 1892 LRAESREQEKALLAL-------QQQCAEQAQEHEVETRALQDSWLQAQ-----AVLKERD 1939
ES+E+E L + ++ C + + + ET+ L ++ + +L E
Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678
Query: 1940 QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ-------HLLEQAELSR 1992
+E+ ++ E R EE + + L+E L + K++ HL E E
Sbjct: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738
Query: 1993 SLEASTAT-----------LQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQ 2041
L + L+ S DA +A +++E LRI +++Q QE + +L+
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ----QETIDKLR 1794
Query: 2042 QALAQRDEELRHQQEREQLLEKSLAQRVQE------NMIQEKQNLGQ-EREEEEIRGLHQ 2094
++++ ++L + Q+ + L +++QE +I K+++ + +++ E+ L +
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 2095 SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELER 2154
+++ LTL++ E E L L + + NLE + S M+E+ L +E L+ E ++
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQ-KLHENLEEMK-----SVMKERD-NLRRVEETLKLERDQ 1907
Query: 2155 LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDE 2214
L+ +L++T+AR++E +++ + + + K +V L+E + + + + +DE
Sbjct: 1908 LKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
Query: 2215 LELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR----Q 2270
L+ + L+K+ L + + ++ E+ ++ + + QS R Q
Sbjct: 1968 LQKKIQELQKKELQLLRVKEDVNMSHK-----KINEMEQLKKQFEAQNLSMQSVRMDNFQ 2022
Query: 2271 RLEHLQQAVARLEI---DRSRLQRHNVQLR-------STL----------EQVERERRKL 2310
+ L +++ + I +R L+R L+ +TL QV+ E+R L
Sbjct: 2023 LTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLL 2082
Query: 2311 K------REAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL-LQAQL 2363
E++R + E+ K + + + + D + E QKE+ + ++A L
Sbjct: 2083 SDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL 2142
Query: 2364 T---LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPE 2403
+ L+ K + T + + S E + L + L V + E
Sbjct: 2143 SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Score = 261 bits (668), Expect = 5e-69
Identities = 458/2252 (20%), Positives = 970/2252 (43%), Gaps = 358/2252 (15%)
Query: 249 LLAKTQELEKEAHERSQ----ELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
L + +E+E + E++ E ++ K++ D E +L ++ L L+ ++ N+D E
Sbjct: 517 LRTEKEEMELKLKEKNDLDEFEALERKTKKDQEM-QLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 305 MIKA-----------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
+ + +++ E +++ E ++ + S S + E+ ++Q + D V +
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 354 EEGDNIAQGSGHENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
+ A +LEL + Y+ + + L +S L +++ DL ++L
Sbjct: 636 DAKRESA--FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693
Query: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
+ L D GK + L L +L+G++ L KE +
Sbjct: 694 FNEITKLTSLID-----GKVPKDLLCNL------------ELEGKITDLQKELNKEVEEN 736
Query: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
E LR+++ +L + L+ + E+ + + + +++ EELH+ E+++L ++ E
Sbjct: 737 EALREEVILLSE----LKSLPSEV----ERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
Query: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
++ L E+ ++ L ++ + QE EQ + + E+
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ---VDLAE 649
+L A K + AL K L+ + +L+E+ + V R+ EQ + L+ L
Sbjct: 849 NLSKEAQKFDSSLGAL---KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE--------KEEIQKKLSESRH 701
E+ + + EK L+ L++ + E + DL+ +QE K +I ++ +
Sbjct: 906 VEREKTLITEK---LQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 702 QQEAATTQLEQL--HQE------AKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
QE LE L HQE +K EEV +R + +E K + ++ +++ +
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEV-SRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI--------- 804
A+ Q L++ ++ ++ + E Q++ + K +L+ +++V KE +
Sbjct: 1021 LEAKNTQTLTA--DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078
Query: 805 -----QGEVRCLKLELDTERSQAEQERDAAAR----------QLAQAEQEGKTALEQQKA 849
Q E+R L EL ++ QE++ A + +LA+ E++ K +Q +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 850 AHEKEVNQLREKWEKERSWHQQELAK--------ALESLEREKMELEMRLKEQQTEMEAI 901
++ +N E E ++ ++ E K LE +E E++EL +L E E+++I
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198
Query: 902 QAQREEERTQAESALCQMQLETEKERV-----SLLETLLQTQKELADA-------SQQLE 949
+R+ + Q ETE++ + + T LQT++EL A + ++
Sbjct: 1199 TKERKVLKE------LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 950 RLR-------------QDMKVQKLKEQETTGILQTQLQEAQRELKEAA--RQHRDDLAAL 994
LR QD++ K QE +L + QE +KE + ++ ++L L
Sbjct: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE-QELLPNVKEVSETQETMNELELL 1311
Query: 995 QE-----ESSSLLQDKMD-------LQKQVEDLKSQLVAQDDSQRLVE------QEVQEK 1036
E +S++L + +M+ Q+ E++KS +D+ + + E +++E
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371
Query: 1037 LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR---------Q 1087
+RET +IQ+ +++ SL + + E +V E + + ++ + LR +
Sbjct: 1372 IRET--LAKIQESQSKQEQSLNMKEKDNETTKIV-SEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 1088 DMQEAQGEQKELSAQMELLR--QEVKEKEADFLAQEAQLLEELEASHI-TEQQLRAS--- 1141
+QE+ E K ++ + + L+ QEV + E+D L + ++E+ A H+ TE++L+ +
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKEN---IKEIVAKHLETEEELKVAHCC 1485
Query: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
L QE +L++ L E+++ + Q QL ++ LQ + + E
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTI------------QKQLEAINDKLQNKIQEIYEKEE 1533
Query: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
+ + + ++ N + FK + +++ S + +L L ++Q+ +
Sbjct: 1534 QF-----NIKQISEVQEKVNELKQ-FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW--EGKQNSLESELMELH 1319
+ + ++++ + E+ Q+ +++ ++ ++QE++ ++ N + ++ E+
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
Query: 1320 ETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379
++ ++ L+ +E + R L Q ENL E +++ E +
Sbjct: 1648 HLKEQFET--QKLNLENIETENIR-LTQILHENL----EEMRSVTKE-----------RD 1689
Query: 1380 DLRTARSALKLKNEEV-ESERER-AQALQEQGELKVAQG--KALQENLALLTQTLAEREE 1435
DLR+ LK++ +++ E+ RE + L++Q ELK+ K QE + L ++E+
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749
Query: 1436 EVETLRGQIQE----LEKQREMQKAALELLSLDLKKRNQEVD----LQQEQIQELEKCRS 1487
E+ ++ ++ L+ Q + L + + LK++ + +D + E+ +L +
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
Query: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLLELEKKDQMIESQRGQVQ 1546
LE+ +QE+ Q+L Q+ L+KD ETQ+ V E + L+ + KDQ + + +++
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869
Query: 1547 DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
+L LA +L EN +E + ++KE + R + TL LE +
Sbjct: 1870 NLN--------LAQKLHEN---LEEMKSVMKERDNLRRVEE------TLKLERDQLKESL 1912
Query: 1607 QSSQIHDLESHSTVLAREL--QERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM--- 1661
Q ++ DLE + + +E + V RE+I E Q + +DL++ EL
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI 1972
Query: 1662 --LQKERIQVL---EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
LQK+ +Q+L ED KI ++EQ+K ++ Q MQ +
Sbjct: 1973 QELQKKELQLLRVKEDVNMSHKKI--NEMEQLK-------KQFEAQNLSMQSVRMDNFQL 2023
Query: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
+K SLE ++++ ++++ EL+ +K+ L+ + + E ++ R
Sbjct: 2024 TKKLHESLEEIRIVAKERD-----------ELRRIKESLKMERDQFIATLRE--MIARDR 2070
Query: 1777 EQEIVVLQQQLQEAREQ---GELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833
+ V +++L +Q L+E+ S++ E + ++ D E L + + +
Sbjct: 2071 QNHQVKPEKRLLSDGQQHLTESLREKC--SRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Query: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV-QALEEVLGDL 1892
E KE + ++ L ++ K H E+ + ++E R+ + L+ VL +
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTK--------HIEKLFTANQRCSMEFHRIMKKLKYVLSYV 2180
Query: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952
EQ +++ + ++ ++ + +Q LQ + R EL L+
Sbjct: 2181 TKIKEEQHESINKFEMDFIDEVEKQKELLIKIQH--LQQDCDVPSR--ELRDLKLNQNMD 2236
Query: 1953 RHQEEAARARAEA--------LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004
H EE + +E+ Q+ L Q E+ L + ++ + +Q
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNG----IQKE 2292
Query: 2005 LD-ACQAHSRQLEEALRI--QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
D CQ ++ + I + E +++ ++ +Q ++L +++E+L + Q L
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL---FKNYQTL 2349
Query: 2062 EKSLAQRVQEN-MIQEKQN-----LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRE 2115
+ SLA Q N Q+ +N + E+IR L S+ E + + KE +I+++++
Sbjct: 2350 KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQK 2409
Query: 2116 TQQRNN-----LEALPH-SHKTSPMEEQSLKL--DSLEPRLQRELERLQAALRQTEAREI 2167
+ N L+A H S+K ++++++ D + + E ++ + ++
Sbjct: 2410 ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDL 2469
Query: 2168 EWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227
E + A++ ++ TKA+V +EV L+ E Q+ QD ++
Sbjct: 2470 EKMKNAKEFEKEISATKATVEYQKEVIRLLR----ENLRRSQQAQDTSVISE-------- 2517
Query: 2228 HSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287
H+ S L G G+ V +A + +S RLE + +++L+
Sbjct: 2518 HTDPQPSNKPLTCGGGSGI----VQNTKA------LILKSEHIRLE---KEISKLKQQNE 2564
Query: 2288 RLQRHNVQLRSTLEQVERE-----RRKLKREA 2314
+L + +L S + + E R LKREA
Sbjct: 2565 QLIKQKNELLSNNQHLSNEVKTWKERTLKREA 2596
Score = 229 bits (584), Expect = 3e-59
Identities = 415/2038 (20%), Positives = 867/2038 (42%), Gaps = 273/2038 (13%)
Query: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKV-LQYRSWCQELEKRLE 78
L + L L+++M E A ++++++N + Q Q +K+Q + + +S E+ K
Sbjct: 644 LRSENLELKEKMKE-LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702
Query: 79 ATGGPIPQRWE-NVE-EPNLDELLVRLEEEQQRCESLAE---VNTQLRLHMEKADVVNKA 133
G +P+ N+E E + +L L +E + E+L E + ++L+ + + + K
Sbjct: 703 LIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE 762
Query: 134 LREDVEKL---TVDWSRARDELMRKESQWQMEQEFF---KGYLKGEHGRLLSLWREVVTF 187
+++ E+L T + + E++ KES+ Q E K L S +E F
Sbjct: 763 IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822
Query: 188 R----------RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--- 234
+ + LE +++++ L E + SL L+ Q +
Sbjct: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV 882
Query: 235 ----------SGRMDGREPA------QLLLLLAKTQELEKEAHERSQE---LIQLKSQGD 275
+++ R+ + L+ K Q+ +E +QE L QL+
Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335
+E+ +L+ + + + +Q+Q + + +K +ET+ L++ +E + + N
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002
Query: 336 EEKLSLQQVIKDITQVMVEEGDN---IAQGSGHENSLELDSSIFSQFDYQDADKALTLVR 392
E K QQ + I + E N + +E IFS Q+ ++ ++
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI--QEKNELQQMLE 1060
Query: 393 SVLTRRRQAVQDLRQQLAGC---QEAVNLL-----QQQHDQWEEEGKALRQRLQKLTGER 444
SV+ + Q DL++ + QE + LL +QQ +E+ A+++ +L+
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE-GELSRTC 1119
Query: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-QLEVLEQEAWRLRRVNVELQLQGDSA 503
D LA L+ + L ++++ L +EE+ + Q ++ E E + N EL L+
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 504 Q----GQK-EEQQEELHLAVRERERLQEMLMGLEAKQS-------ESLSELITLREALES 551
+ QK E EE+ +ER+ L+E+ E ++ E + + +E L+
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239
Query: 552 SHLE-------GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604
+H+ + LR+ +E TA + + +L S L+ E+ L L +
Sbjct: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQ----DLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664
E + +N+ L E+ + + E R L E+++ ++L ++ +L
Sbjct: 1296 KEVSETQET-MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA--ATTQLEQLHQEAKRQEE 722
+ + E +L+ +R+ + +E Q K +S + +E TT++ ++ K ++
Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414
Query: 723 VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSV 782
L R E L + +++V +++ DL + L S + L+ ++ E ++
Sbjct: 1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHL- 1473
Query: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
T+ +L+V + + +E I E+R E +TE S +++ +A +L QE
Sbjct: 1474 --ETEEELKVAHCCLKEQEETI-NELRVNLSEKETEISTIQKQLEAINDKLQNKIQE--- 1527
Query: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAK--ALESLEREKMELEMRLKEQQTEM-- 898
E+++ + K++++++EK + + + + AK AL+S+E + +EL RL+E Q E+
Sbjct: 1528 IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 899 ------------EAIQAQREEERTQAESALCQMQLETEKERVSLLETLL-QTQKELADAS 945
EA+Q +R++ + + + +M+ EKE L T + +TQ+++
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC--- 1644
Query: 946 QQLERLRQDMKVQKLKEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
++E L++ + QKL + ET I TQ+ E + + RDDL +++E +L
Sbjct: 1645 -EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE---TLKV 1700
Query: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLV------EQEVQEKLR-----ETQEYNRIQKELER 1052
++ L++ + + ++ + + + ++V QE +KLR +T E + +QK+LE
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 1053 EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE 1112
+L ++ ++ L + +Q+ + LR + E + + +E +++E
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 1113 KEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
K + A E QL+ + + T++++ ++ QL+ +++ L L E
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKV--------SEMEQLKKQIKDQSLTLSKLEIENL- 1871
Query: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232
N AQ L+ L++ + SV + R L LE DQ
Sbjct: 1872 -NLAQ------KLHENLEE-MKSVMKERDNLR----RVEETLKLERDQ------------ 1907
Query: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
L E A L ++ Q+L + ++ V KL E++ S+ ++ D+Q+
Sbjct: 1908 LKESLQETKARDL-EIQQELKTARMLSKEHKETVDKLREKI-------SEKTIQISDIQK 1959
Query: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352
L ++++E K + E +L+ + E + ++ E + + + + +Q+ + +
Sbjct: 1960 DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMD 2019
Query: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
+ L ++ E R A ++LR + +LK++ ++ + A Q
Sbjct: 2020 NFQLTKKLHESLEEIRIVAKE----RDELRRIKESLKMERDQFIATLREMIARDRQNHQV 2075
Query: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
+ + L + LT++L E+ ++ L + E++ E L LSLDL+K E+
Sbjct: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYE----CLNRLSLDLEK---EI 2128
Query: 1473 DLQQE--------------QIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE 1518
+ Q+E Q + +EK + + M +KL + ++++++
Sbjct: 2129 EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH 2188
Query: 1519 TQRNVLEHQLL-ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHH---------- 1567
N E + E+EK+ +++ + QD L L L + H
Sbjct: 2189 ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248
Query: 1568 ------KMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES--HST 1619
K E QQ L E + + T D+E+ +Q ++ +I + + ++
Sbjct: 2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR--FDIEKLKNGIQKENDRICQVNNFFNNR 2306
Query: 1620 VLA-----RELQER--------DQEVKSQREQIEELQRQKEHL-------------TQDL 1653
++A E +ER +Q++KS +E+ E+L + + L TQD
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366
Query: 1654 ER---RDQELMLQKERIQVLEDQ--------RTRQTKI--LEEDLE---------QIKLS 1691
+ + L E+I+ LE+ +++KI ++++LE Q K+
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426
Query: 1692 LRERGRELTTQR-QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
+ E T + Q++Q++ G P K + L+ MKL+ D EK ++ +E E+
Sbjct: 2427 ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLK-MKLVKIDLEK-MKNAKEFEKEISA 2484
Query: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810
K +E Q + + ++ +L SQ+ Q+ V+ + L S + + +
Sbjct: 2485 TKATVEYQKEVI--RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGG-GSGIVQNTK 2541
Query: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQG--ALEQAHMTLKERHGELQDHKE 1866
AL + + + ++ + Q E+ +K+K + L L T KER + + HK+
Sbjct: 2542 ALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 252 bits (644), Expect = 3e-66
Identities = 305/1392 (21%), Positives = 627/1392 (45%), Gaps = 212/1392 (15%)
Query: 845 EQQKAAHEKEVNQLREKWE------KERSWHQQELAKALES---LEREKMELEMRLKEQQ 895
E A +V LR++ + KE W+ +EL K LE L++++ + + + +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
E+++++ Q EE +T+ + L +K Q E+AD + +
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAA--------QLATEIADIKSKYDE----- 181
Query: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD-KMDLQKQ--V 1012
+R L+EAA Q L + ++++QD K +L ++ +
Sbjct: 182 ---------------------ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
Query: 1013 ED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
ED LK +LV Q L++ E+ RE+++ K+L+ + AS ++ + L
Sbjct: 221 EDVAVLKKELV---QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL- 276
Query: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129
+ QE++ Q++Q+ + EL+ + + L + + +KE D+ E + EE
Sbjct: 277 ------AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEE-- 328
Query: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ-----AQLAS 1184
++++ ++A+L ++ QLQ RL ++E+ L + E +A + +++ +
Sbjct: 329 --SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET 386
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Y L+ + + R E +Q+G + + S
Sbjct: 387 KYQHLKAEFKQLQQQREE---------------KEQHGLQ----------------LQSE 415
Query: 1245 LHKLHQDLWKTQ----QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS----- 1295
+++LH L +T+ + L++Q Q E+L D E + + + +L L+ QL
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 1296 ----QNQEEKSKWEGKQNSL--ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA 1349
Q+Q +K+K + ++ +S +L E L+ LR+ + + Q LLQ +
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 1350 KENLTA---QVEHLQAAVVEARAQASAAGILEEDLRTARSAL-----KLKNEEVESERER 1401
KEN++ + E L A + + + L+E T + + KLKN+ ES ++
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS-ESHKQA 594
Query: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
+ L +Q + + A +A Q+ + L ++ E ++ + ++ +L+ Q KA ELL
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI---KAKTELL 651
Query: 1462 -SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ---KLTVQREQIRELEKDR 1517
S + K Q DLQ L+ A+Q+++Q K+T Q +Q+ +D+
Sbjct: 652 LSAEAAKTAQRADLQNH-----------LDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
Query: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577
+ + LE L E ++K +E + ++L+ Q+ LE +LE++ + +++ ++
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQK---TEELEGQIKKLEADSLEVKAS------KEQALQ 751
Query: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
+L+ QR+ L DLE R+ EL Q ++ S + + +LQ++ + ++S ++
Sbjct: 752 DLQQQRQ--------LNTDLELRATELSKQLEMEKEIVSSTRL---DLQKKSEALESIKQ 800
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKE----RIQ--VLEDQRTRQTK-ILEEDLEQIKL 1690
++ + + +K+ L QD E QE +Q E RIQ V E Q+ + K L +L +K
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 1691 SLRERGRELTTQRQLMQERAEEGKGP----SKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
L + L + ++ ++GK K + +++ + + KE + ++ +
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
+ +E QL+ +L + ++ + L Q E+E LQ + E ++ E K++ +++
Sbjct: 921 KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 980
Query: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE-------RHG 1859
E + A+ Q+ + LQQ+ QA + KEK LQ E++ T K+ R
Sbjct: 981 ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
Query: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
EL ++ + +EE+L++ + + +G+ +E + A L+Q A++ Q+ +
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 1920 ETRALQDSWLQAQAVLKERD--------QELEAL--RAESQSSRHQEEAARARAEALQEA 1969
+ALQD +Q + LKE++ E+E + R E + ++ EE + E+++E
Sbjct: 1101 RCKALQD--IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI 1158
Query: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
L+ +Q L++Q L+ +L+A+++ + + + L++ ++ +E E++ +
Sbjct: 1159 TN-----LKDAKQLLIQQ---KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
Query: 2030 DLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEI 2089
+ E +L + +++ ++ +E E L + +NLG ++E +
Sbjct: 1211 ---FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL--------NENLGTVKKEWQ- 1258
Query: 2090 RGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ 2149
+ V EL+ EI L T Q N E + E + KL + LQ
Sbjct: 1259 -SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317
Query: 2150 RELERLQAALRQ 2161
R+L+ AA+++
Sbjct: 1318 RKLDNTTAAVQE 1329
Score = 229 bits (584), Expect = 3e-59
Identities = 321/1396 (22%), Positives = 604/1396 (43%), Gaps = 157/1396 (11%)
Query: 1016 KSQLVAQDDSQRLVEQEVQE---KLRETQEYNR-IQKELEREKASLTLSLMEKEQRLLVL 1071
+S L + D L+ QEVQ+ L+E + Y+ ++KELE+ + L E + LV
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKPDGLVT 131
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
+ EL +L Q ++EAQ E + +L Q+ AQ A + ++++
Sbjct: 132 DSS-----AELQSLEQQLEEAQTENFNIKQMKDLFEQKA--------AQLATEIADIKSK 178
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQ--AQAQAQLASLYS 1187
+ E+ LR A E K +L L + ++ L E Q+PG + A + +L + +
Sbjct: 179 YDEERSLRE---AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT 235
Query: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGL-EPDQNGARSLFKRGPLLTALSAEAVASALH 1246
+ +L S + E + RS +GP A+ + +
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 1247 KLHQDLWKTQQTRDVLRDQVQ---KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK 1303
+++ K Q + L + Q KLEE+ + K + L Q Q S
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 1304 WEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN-------LTAQ 1356
E + + EL E E L+ L E + + E + LQ +E L ++
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 1357 VEHLQAAVVEARAQASAA-GILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
+ L + ++E Q A G L+E + + L K ++V + + L+EQ + KV
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
LQ L Q E++ ++ +++E Q ++++ ++ D K +N E LQ
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREA--QNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 1476 Q--EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL-ELE 1532
+ E I LEK R E L +Q E + V Q++E + Q L +L + E
Sbjct: 534 KSKENISLLEKER---EDLYAKIQAGEGETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSE 589
Query: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
Q E+ QVQ+ K L + L LE + +++ Q KE Q + Q A T
Sbjct: 590 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649
Query: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE----LQRQKEH 1648
L L E A+++Q DL++H LQ++ QE+ Q+++ LQ ++EH
Sbjct: 650 LLLSAEA------AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703
Query: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
+Q LE +E + ++ ++ Q K LE D ++K S + ++L QRQL +
Sbjct: 704 CSQ-LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE 1768
++L + K++E ++E + + + + L+ + +K
Sbjct: 763 ------------------LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK--- 801
Query: 1769 TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQ 1828
L+++E+E +L+Q + ++ +++ + L +++ L + E EAL E
Sbjct: 802 ----LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
Query: 1829 AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
+ +++ + +D+L+ + + ++ + D ++ + L+ +L V+ +E
Sbjct: 858 VK---DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ------MENT 908
Query: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
L +EQ++ +L+++ E + + ++E ++Q+ +QAQ LK+ ++E + L+
Sbjct: 909 L-------KEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008
+ E + + EALQ L A +L++ EL L+ Q A
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIA----------VLQKTELENKLQ------QQLTQAA 1004
Query: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Q + + E+ +Q+ + QE +QLQ R+ EL ++ + +E+ L+
Sbjct: 1005 QELAAEKEKI-----SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL- 1058
Query: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE----LRETQQRNNLEA 2124
QE++I + +G + + I+ L + L+ A+KEQ++ E L++ Q+ +L+
Sbjct: 1059 AQEDLISNRNQIGNQNKL--IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 2125 LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184
++ S + E ++ ++ R ++E+ +L L+ + I+ +D L Q K
Sbjct: 1117 KELVNEKSKLAE----IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 2185 ASVSSLQEVAMFLQASVLERDSEQQRLQDEL-----ELTRRALEKE-RLHSPGATSTAEL 2238
LQ A L+A+V + QQ L+D++ EL + +EKE +LHS E+
Sbjct: 1173 LE---LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS--EIKEKEV 1227
Query: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRS 2298
G + + + + A G K+ W+ Q+ V+ LE L+ L +
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSS----QRRVSELEKQTDDLRGEIAVLEA 1283
Query: 2299 TLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL 2358
T++ + ERR L ++ G EI K Q R N+ A V EL +E
Sbjct: 1284 TVQNNQDERRALLERCLK----GEGEIEKLQTKVLELQ--RKLDNTTA-AVQELGRENQS 1336
Query: 2359 LQAQLT--LERKQKQD 2372
LQ + T L RK +D
Sbjct: 1337 LQIKHTQALNRKWAED 1352
Score = 218 bits (556), Expect = 4e-56
Identities = 293/1433 (20%), Positives = 627/1433 (43%), Gaps = 158/1433 (11%)
Query: 279 AELQDRVTELSALLTQSQKQNEDY--EKMIKALRETVEILETNHTELMEHEASLSRNAQE 336
++L T ++ + ++ +E + + +K+L E+ + H E + + S + E
Sbjct: 18 SDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFK--HYEAVHDAGNDSGHGGE 75
Query: 337 EKLSLQQVIKDITQVMVEEGD---NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRS 393
L+L++ D+T + E D ++ + + L+ + + Q+A
Sbjct: 76 SNLALKR--DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPD-----G 128
Query: 394 VLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL----QKLTGERDTLAG 449
++T +Q L QQL Q ++Q D +E++ L + K ER
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEE 509
+ + L+KE ++Q + EL Q+ + ++ L++ V++Q D+ ++E
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGI--EDVAVLKKELVQVQTLMDNMTLERE- 245
Query: 510 QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569
RE E+L++ L+++ + S + + LR L E + QE
Sbjct: 246 ---------RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE------- 289
Query: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
L + + S+ EL+ TL + KL + ++ K + L Q + + Q +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689
SR+ A+E + + + V+L+E + + L E+ + +E + Q + +LQ + ++
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
++Q ++++ + QL + H K Q ++ + + +KE ++ A L+++L +E
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE---QQVADLQLKLSRLE 466
Query: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL-EVQIQTVTQAKEVIQGEV 808
+ L E++ + + L+ + + Q+Q ++ + T +L E Q +++ +
Sbjct: 467 ---EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 809 RCLKLELDTERSQ-----AEQERDAAARQLAQAEQEGKTALEQQKAAH--EKEVNQLREK 861
+ LE ++S+ E+ER+ ++ E E + Q+ H +++V QL EK
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 862 WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL 921
+ + H+Q A E+L + E + L+ Q + +++ E QL
Sbjct: 584 LKNQSESHKQ----AQENLHDQVQEQKAHLRAAQDRVLSLETSVNE---------LNSQL 630
Query: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
KE+VS L+ ++ + EL +++ + Q+ Q Q LQ+ Q+EL
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAK------TAQRADLQNHLDTAQNALQDKQQELN 684
Query: 982 EAARQHRDDLAALQEESSSLLQ----------DKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
+ Q A LQ++ Q + L+++ E+L+ Q+ + V+
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE-LSALRQDMQ 1090
++ L++ Q+ ++ +LE L+ L E E+ ++ D ++ E L +++Q +
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQL-EMEKEIVSSTRLDLQKKSEALESIKQKLT 803
Query: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
+ + E++ L E L QE K + + + + EL+ + ++ L L + K +
Sbjct: 804 KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
Query: 1151 QLQLRLRSTESQLEALAAEQQPGNQA--QAQAQLASLYSALQQALGSVCESRPELSGGGD 1208
++ L++++S+ E E Q G A + L LQ + + + + EL
Sbjct: 864 KVSDSLKNSKSEFE---KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK--- 917
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQK 1268
LE ++ + L L E + A + L Q+ + QQ + + + Q
Sbjct: 918 ------SLEKEKEASHQL----KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 1269 LEERLTDTEAEKSQV------HTELQD-LQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
E++ EA + ++ TEL++ LQ+QL+Q +E + + K + L++ + ET
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
LQS E E R+ L++ +E L+ E L + R Q L ++L
Sbjct: 1028 FKQLQSDFYGRE---SELLATRQDLKSVEEKLSLAQEDL----ISNRNQIGNQNKLIQEL 1080
Query: 1382 RTARSALKLKNEEVESE-RERAQALQEQGELKVAQGKAL---QENLALLTQTLAEREEEV 1437
+TA++ L+ + + E + +ER +ALQ+ + K + K L + LA + + +E+E+
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
L E++ LE +K+ D +Q IQ+ + + + L AV+
Sbjct: 1141 TKL---------NEELKSHKLE----SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557
+ ++ + ++Q+++ E+ E K + IE + ++K++ V ++
Sbjct: 1188 QEKRNQQILKDQVKKEEE----------------ELKKEFIEKEAKLHSEIKEKEVGMK- 1230
Query: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
+ EEN K+ Q + E G + + + +LE+++ +L+ + + + +
Sbjct: 1231 ---KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 1618 STVLARELQER----DQEVKSQREQIEELQRQKEHLT---QDLERRDQELMLQ 1663
+ R L ER + E++ + ++ ELQR+ ++ T Q+L R +Q L ++
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 179 bits (455), Expect = 2e-44
Identities = 299/1380 (21%), Positives = 578/1380 (41%), Gaps = 200/1380 (14%)
Query: 56 VRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWE--------NVEEPNLDELLVRLEEEQ 107
V+ LQA + + + + +EL+K LE G Q + + E +L++ L + E
Sbjct: 92 VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151
Query: 108 QRCESLAEVNTQ--LRLHMEKADVVNK-----ALREDVEKLTVDWSRARDELMRKESQWQ 160
+ + ++ Q +L E AD+ +K +LRE E+ +R +EL ++ + Q
Sbjct: 152 FNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV---TRLTEELNKEATVIQ 208
Query: 161 -MEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRL-----SG 214
++ E + + + L +E+V + M +R+ +LK E +L S
Sbjct: 209 DLKTELLQ---RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265
Query: 215 SLLTCCLR---------LTVGAQSREPNGSGRMDGREPAQLLL--LLAKTQELEKEAHER 263
LR + V Q + S + + Q L LL K Q+ K +
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 264 SQELIQLKS------QGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
++E + K+ Q DL+ +LQ R++ L + + + + + L+E + +E
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 318 TNHTELMEHEASLSRNAQEEK---LSLQQVIKDITQVMVEEGDNIAQGSGH-ENSLELDS 373
T + L L + +E++ L LQ I + ++E + + G + +L S
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ Q AD L L+R + +++ Q ++ +QQH + + ++
Sbjct: 446 EKLMDKEQQVADLQLK-----LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSL------SKER-ELLQKAREELRQQLEVLEQEA 486
+L++ + + + Q D ++ +L SKE LL+K RE+L +++ E E
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 487 W---RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--RERLQEMLMGLEAKQSESLSE 541
+L+ N LQ Q +K + Q E H +E +++QE L A Q LS
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLT-EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS- 618
Query: 542 LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT-EVADLRAAAVK 600
LE+S E E E + L ++ EL S KT + ADL+
Sbjct: 619 -------LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN---H 668
Query: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
L AL + LN+ QL++ V ++++ ++ + L+ L E +++ +L +K
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQ----VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
LE Q++K L+AD +++ KE+ + L QQ T LE E +Q
Sbjct: 725 TEELEGQIKK-------LEADSLEVKASKEQALQDL----QQQRQLNTDLELRATELSKQ 773
Query: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
E+ EKE + + L+ + +A+E +Q L +Q K++L+ FE Q
Sbjct: 774 LEM------EKEIVSSTRLDLQKKSEALESIKQKLTKQ----EEEKQILKQD-FETLSQE 822
Query: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE--- 837
+ I+ +L +IQT + ++ E L EL T + + + D+ ++ E
Sbjct: 823 TKIQ--HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Q+GK A+ + ++ +QL+ + E Q+EL K+LE + +L++ L Q
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLK-EQKELKKSLEKEKEASHQLKLELNSMQ-- 937
Query: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
E+ QA++ L Q EKE L + + ++ +Q+E L+ ++K+
Sbjct: 938 ---------EQLIQAQNTLKQ----NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 958 QKLKEQETTGILQTQLQEAQREL---KEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
L++ E LQ QL +A +EL KE +++ QE L D + ++
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074
+ L + ++ L ++++ + N++ +EL+ KA+L +KEQ+L
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL------ 1098
Query: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134
Q+ AL+ +E ++KEL + L E++E + + +L EEL++ +
Sbjct: 1099 ----QERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKLE 1153
Query: 1135 EQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194
+ +L + Q +L L+ L+A A EQ+ NQ + Q+
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGKADSLKA-AVEQEKRNQQILKDQVKK---------- 1202
Query: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH-----KLH 1249
E ++ + K L + + + V H KL
Sbjct: 1203 ----------------------EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS------- 1302
+ + ++ + Q + R+++ E + + E+ L+ + NQ+E+
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQA 1362
K EG+ L+++++EL + + + ++ + +EN + Q++H QA
Sbjct: 1301 KGEGEIEKLQTKVLELQRKLDNTTAAVQ----------------ELGRENQSLQIKHTQA 1344
Score = 167 bits (422), Expect = 2e-40
Identities = 230/1134 (20%), Positives = 481/1134 (42%), Gaps = 158/1134 (13%)
Query: 29 QQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRW 88
Q + EN + +E ++ + +QA + Q CQ+L+ RL A+
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS-------- 356
Query: 89 ENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRA 148
E +L + V L E+ + + L E +++ + K L++ E+
Sbjct: 357 ----ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-------- 404
Query: 149 RDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAE 208
+++ Q++ E + H +LL R++ E + + LM+ + +
Sbjct: 405 -----KEQHGLQLQSE-----INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 209 HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268
L L RL + + N + Q L K Q E++A ++S
Sbjct: 455 VADLQLKL----SRLEEQLKEKVTNST-------ELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 269 QLKSQGDLEK-----AELQDRVTELSALLTQS-------QKQNED-YEKMIKALRETV-- 313
++Q DLE+ + ++ L ALL +S +K+ ED Y K+ ET
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 314 -EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL--- 369
++ E NHT L E L+ + + S +Q +++ + E+ ++ SL
Sbjct: 564 NQLQEKNHT-LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 370 --ELDSSI------FSQFDYQ---------DADKALTLVRSVLTRR----RQAVQDLRQQ 408
EL+S + SQ D Q A+ A T R+ L + A+QD +Q+
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 409 LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL 468
L ++ + + +E L L++ + +L +T +L+G++ L + +
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 469 QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEML 528
+ ++E+ Q L+ + R++N +L+L+ Q E ++E + + ++ E L
Sbjct: 743 KASKEQALQDLQ-------QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 529 MGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
++ K ++ E L++ E+ E ++ +E R + ++ EL + +
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN------RIQTTVTELQKVKMEKE 849
Query: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ----SVCSRMEAAEQARNALQ 644
+ +L KLS ++++L K + E+ENQ ++ + ++ ++ LQ
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSK-------SEFEKENQKGKAAILDLEKTCKELKHQLQ 902
Query: 645 VDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
V + K ++ L+ L+K +EA +L+ +L +QE+ + Q L ++ +++
Sbjct: 903 VQMENTLKEQK-------ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSS 764
+ +L Q ++++++ + E + V +K LE +LQ Q L + Q L++
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ------QQLTQAAQELAA 1009
Query: 765 AKE---LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
KE +L+++ ++Q+ ++ E ++ Q + ++ ++ + +L + R+Q
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
+ +L Q + K LEQ A E+++ QE KAL+ ++
Sbjct: 1070 IGNQ-----NKLIQELKTAKATLEQDSAKKEQQL---------------QERCKALQDIQ 1109
Query: 882 REKMELEMRL---KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ 938
+EK E L K + E+E I+ ++E+E T+ L +LE+ KE + L +
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE----ITNLKDAK 1165
Query: 939 KELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
+ L +L+ +K +E+ IL+ Q+++ + ELK+ + L
Sbjct: 1166 QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL------H 1219
Query: 999 SSLLQDKMDLQKQVED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKA 1055
S + + ++ ++K E+ L Q+ A +++ V++E Q R E + +L E A
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
Query: 1056 SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
L ++ + L E + E+ L+ + E Q + +A ++ L +E
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
Score = 164 bits (414), Expect = 1e-39
Identities = 225/1045 (21%), Positives = 455/1045 (43%), Gaps = 113/1045 (10%)
Query: 1379 EDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVE 1438
+DL+ + K +EE++ E E+ Q LQ+Q A+ L + + Q+L ++ EE +
Sbjct: 93 QDLQASLKEEKWYSEELKKELEKYQGLQQQE----AKPDGLVTDSSAELQSLEQQLEEAQ 148
Query: 1439 TLRGQIQELEKQREMQKAALELLSLDLK-KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
T I++++ E + A L D+K K ++E L++ Q++ + L +Q
Sbjct: 149 TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208
Query: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557
+ + +L +QR I ++ VL+ +L+ QVQ L +
Sbjct: 209 DLKTEL-LQRPGIEDVA--------VLKKELV--------------QVQTLMDNMT---- 241
Query: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
L E E K EC K+L+ Q + ++ L +L + QE+ ++ L+S
Sbjct: 242 LERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677
EL +++Q + E L ++++ T+ LE + E + K+ IQ Q+
Sbjct: 297 ----VNELTQKNQTLT------ENLLKKEQDYTK-LEEKHNEESVSKKNIQATLHQKDLD 345
Query: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737
+ L+ L + SL EL+ + + Q+ EE +H+K + +++
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE----LSEVETKYQHLKAEFKQLQQQ 401
Query: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG--- 1794
E +++H +LQ +QL +L R++GE L ++ Q + ++L + +Q
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ---LSSEKLMDKEQQVADL 458
Query: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854
+LK L+ QL E + +L+ +Q+ Q+ Q ++ K Q LEQ +
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Query: 1855 KERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQA 1914
++ ++Q+ LE L + LE+ DL A+ + E L Q Q
Sbjct: 519 GDKDQKIQN-------LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL---QE 568
Query: 1915 QEHEVETRALQ-DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
+ H ++ + Q L+ Q+ + Q E L + Q + AA+ R +L+ ++ +
Sbjct: 569 KNHTLQEQVTQLTEKLKNQS--ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRY 2033
++ L ++ + ++L ++A T L ++ A A L+ L + +QD+
Sbjct: 627 NSQLNESKEKV---SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
+ QL Q A+ ++ H + E L++ +++ L E++ EE+ G
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQLESHLKE-----------YKEKYLSLEQKTEELEGQI 732
Query: 2094 QSVRELQLTL-AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152
+ + L + A KEQ + +L++ +Q N L + + +E + + S LQ++
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTK-----------ASVSSLQEVAMFLQASV 2201
E L++ ++ +E E + QD +TK +V+ LQ+V M +A +
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 2202 LERDSEQQRL---QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258
E + + +L D L+ ++ EKE A E + +L V+ E
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK-----ELKHQLQVQMEN 907
Query: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAA 2318
+ E++ ++ LE ++A +L+++ + +Q +Q ++TL+Q E+E ++L+
Sbjct: 908 TL--KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 2319 QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQ---KQDYIT 2375
Q+ + + A + QK + +LQ+++ +L E+++ Q+
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQK---TELENKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 2376 RSAQTSRELAGLHHSLSHSLLAVAQ 2400
+S +T ++L + LLA Q
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQ 1047
Score = 87.0 bits (214), Expect = 2e-16
Identities = 153/798 (19%), Positives = 332/798 (41%), Gaps = 104/798 (13%)
Query: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
L+EQV L +++ + + +N + Q Q +R Q +VL + EL +L
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVE 139
+ + Q +++ ELL+ E + L+ H++ A + ++++
Sbjct: 633 SKEKVSQL--DIQIKAKTELLLSAEAAK------TAQRADLQNHLDTAQNALQDKQQELN 684
Query: 140 KLTVDWSRARDELMRKESQW-QME---QEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMK 195
K+T + +L K+ Q+E +E+ + YL E + L ++ LE+K
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ-KTEELEGQIKKLEADSLEVK 743
Query: 196 SATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGREPAQLL-LLLAKT 253
++ ++ L +L+ + +L+ L L+ + +E S R+D ++ ++ L + K
Sbjct: 744 ASKEQALQDLQQQR-QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDR----VTELS-------ALLTQS------- 295
+ E+E Q+ L + ++ EL +R VTEL AL+T+
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 296 --------------QKQNE-------DYEKMIKALRETVEILETNHTELMEHEASLSRNA 334
+K+N+ D EK K L+ +++ N ++ + L ++
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN---TLKEQKELKKSL 919
Query: 335 QEEKLSLQQV---IKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDAD------ 385
++EK + Q+ + + + +++ + + Q E L+ + + Q Q
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 386 ---KALTLVRSVLTRR-RQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
K L ++ L + +Q + Q+LA +E +++LQ +++ +E K L+
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY--- 1036
Query: 442 GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD 501
G L DL+ + LS +E L R ++ Q +++++ L+ L+
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE----LKTAKATLEQDSA 1092
Query: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-------SLSELITLREALESSHL 554
+ Q +E+ + L +E+ ++ L+ ++K +E E+ L E L+S L
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 555 EG-----------ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
E +LL Q++ E+ + ++ + ++ LK +V K
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAA--------EQARNALQVDLAEAEKRRE 655
EA ++ + ++ EEN++ + A ++ + Q ++E EK+ +
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 656 ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
L + LEA +Q ++ L + E E++Q K+ E + + + T +++L +
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGR 1332
Query: 716 EAKRQEEVLARAVQEKEA 733
E + + +A+ K A
Sbjct: 1333 ENQSLQIKHTQALNRKWA 1350
Score = 36.6 bits (83), Expect = 0.31
Identities = 60/312 (19%), Positives = 124/312 (39%), Gaps = 29/312 (9%)
Query: 2114 RETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKA 2173
R Q ++L++ T + +S + P+ + L + EA +
Sbjct: 12 RVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSG 71
Query: 2174 QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGAT 2233
+LA + V+ L++ LQAS+ E + L+ ELE + L+++ G
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLV 130
Query: 2234 STAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHN 2293
+ + E+ +E + E + +Q + +Q A+L + + ++
Sbjct: 131 TDSS-----------AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKY 179
Query: 2294 VQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQ 2353
+ RS E E++ +L E + A ++ P +D VA L+
Sbjct: 180 DEERSLREAAEQKVTRLTEELNKEATV-IQDLKTELLQRPGIED-----------VAVLK 227
Query: 2354 KEVVLLQA---QLTLERKQKQDYI-TRSAQTSRELAGLHHSLSHSLLAVAQAP-EATVLE 2408
KE+V +Q +TLER+++ + + + + A ++S +A+ P E V
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
Query: 2409 AETRRLDESLTQ 2420
E ++L S+ +
Sbjct: 288 QELQKLKSSVNE 299
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 239 bits (611), Expect = 2e-62
Identities = 361/1726 (20%), Positives = 742/1726 (42%), Gaps = 244/1726 (14%)
Query: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
S +N L+ +AD ++ L +E KV QQ ++E+ R+ +
Sbjct: 20 SVQNKLEKFLADQQSEIDGLKGRHEKF---KVESEQQYFEIEKRLSHSQERLVNETRECQ 76
Query: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
+L+++L + + +AL EKN LE A++ +Q+ +EE E ++ L +
Sbjct: 77 SLRLELEKLNNQLKALTEKNKELEI----AQDRNIAIQSQFTRTKEELEAEKRDLIRTN- 131
Query: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761
E + +LE L ++ KR E L + K L + L+ +V+ + L ++ +
Sbjct: 132 --ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
Query: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQ--LEVQIQTVTQAKEVIQGEVRCLKLELDTER 819
L S L + L + + KG LE++ + +EV + E + L+ E
Sbjct: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
Query: 820 SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE---RSWHQQELAKA 876
Q E D + K A EQQ + EK N+L + +S AK+
Sbjct: 250 LQKHVE-DLLTKL--------KEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS 300
Query: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
E L R EL LKE +AIQ + + E + QM+ E +LE + +
Sbjct: 301 NE-LTRAVEELHKLLKEAGEANKAIQ----DHLLEVEQSKDQMEKE-------MLEKIGR 348
Query: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
+KEL +A+ L ++ + L E+E + T A+ + + + + A E
Sbjct: 349 LEKELENANDLLSATKRKGAI--LSEEELAAMSPTAAAVAK--IVKPGMKLTELYNAYVE 404
Query: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKAS 1056
LL +K++ K++ ++V + VE + R+ +EY R QK + AS
Sbjct: 405 TQDQLLLEKLE-NKRINKYLDEIVKE------VEAKAPILKRQREEYERAQKAV----AS 453
Query: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
L++ L + + + LQE ++ S L +D + + + K+LS Q+ +L E++E +
Sbjct: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
Query: 1117 FLAQEAQL---------------------LEELEASH---------ITEQQLRASLWAQE 1146
+ ++ ++ +EEL+ + + E + R
Sbjct: 514 HVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTS 573
Query: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
+K +LQL+L S ++LE L +Q +Q Q + + L L
Sbjct: 574 SKITELQLKLESALTELEQLRKSRQ--HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHAS 631
Query: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV-ASALHKLHQDLWKTQ-----QTRD 1260
S+ + ++++ P+ S EA+ A A K Q++++ +
Sbjct: 632 SLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEK 691
Query: 1261 VLRDQVQKLEERLTDTEAEKSQVHTEL--------------QDLQRQLSQNQEEKSKWEG 1306
+ +Q++KL+E++TD ++ +++ T+L + +R+++ E K
Sbjct: 692 IQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366
E + + + + +L AE++ + E+E+L+ ++ L+ Q E L A E
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA---E 808
Query: 1367 ARAQ-------ASAAGILEEDLRTARSAL-----KLKNE------EVESERERAQALQEQ 1408
R Q + GILE + L KL++E ++E+E E+ L
Sbjct: 809 QRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRN 868
Query: 1409 GELKVAQGKA---LQENLALLTQTLAER-EEEVETLRGQIQELEKQREMQ---------- 1454
++++ K + NL L T+ L + ++E+ TL+ + +E Q Q
Sbjct: 869 LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
Query: 1455 --KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512
K ++ L L++ ++V+ +E+ L+ S +E V E+ L +++ E
Sbjct: 929 SNKEDVDDLVSQLRQTEEQVNDLKER---LKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
Query: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ 1572
+ K+ E + +LEKK +E ++ ++QD K++ + E + +L E +
Sbjct: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI--ESMEQQLSELKKTLSSV 1043
Query: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQ-ELQAQSSQIHDLESHSTVLARELQERDQE 1631
Q ++E + T D +E+++ ++AQ+ +L H+ + +
Sbjct: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADV--------EA 1095
Query: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQK----ERIQVLEDQRTR----------Q 1677
+++ +EQ+ ++ ++HL + ++ + +L+ K ER ++L+D+ ++ Q
Sbjct: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
Query: 1678 TKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE-- 1735
++L + +E++ + +E Q L +EEGK +Q LE ++ I R+KE
Sbjct: 1156 NRLLHDQIEKLSDKVVASVKE-GVQGPLNVSLSEEGK----SQEQILEILRFIRREKEIA 1210
Query: 1736 ---------------KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
+ VE + + ELQ+ + +++Q + + + L+ + E
Sbjct: 1211 ETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMN 1270
Query: 1781 VVLQ--QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
VV++ + L+E +E+ E Q +Q+++ + + + + L ++ Q +++ ++E
Sbjct: 1271 VVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
D + H+ +++ + +++ R+L E V +R+Q L E +G L+AE
Sbjct: 1331 --DVKRWKARNQHLVSQQKDPDTEEY----RKLLSEKEVHTKRIQQLTEEIGRLKAEIAR 1384
Query: 1899 QEKALLALQ---QQCAEQAQEHEVETRALQDSWLQAQAV-LKERDQELEALRAESQSSRH 1954
+L Q Q E + E +Q L A+ + ++E+ + + ++ + +
Sbjct: 1385 SNASLTNNQNLIQSLKEDLNKVRTEKETIQKD-LDAKIIDIQEKVKTITQVKKIGRRYKT 1443
Query: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Q E +A+ + + E A ++ +EQH+ Q L+ +L+ + S+
Sbjct: 1444 QYEELKAQQDKVMET--SAQSSGDHQEQHVSVQ---------EMQELKETLNQAETKSKS 1492
Query: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA---QRVQE 2071
LE V+ LQ+ L++++ E R+ QE+ L+ L+ Q +Q+
Sbjct: 1493 LES------------------QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
Query: 2072 NMIQEKQNLGQ--EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
QE+Q Q E+EE+ + + + ++ K+Q E E +QRN AL
Sbjct: 1535 RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNG--ALDQQK 1592
Query: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQD 2175
+E +++ +L+ + + + RL+ LR+ + R +E R++ Q+
Sbjct: 1593 -----DELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
Score = 228 bits (580), Expect = 7e-59
Identities = 365/1736 (21%), Positives = 727/1736 (41%), Gaps = 249/1736 (14%)
Query: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
+LEK ++ E+ LK + + K E + + E+ L+ SQ++ + + ++LR +E
Sbjct: 24 KLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELE 83
Query: 315 ILETNHTELMEHEASLSRNAQEEKLSLQ-QVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
L L E L AQ+ +++Q Q + ++ E+ D I +
Sbjct: 84 KLNNQLKALTEKNKELEI-AQDRNIAIQSQFTRTKEELEAEKRDLI----------RTNE 132
Query: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ + +Y D V+ L ++L LQ + D+ + ++
Sbjct: 133 RLSQELEYLTED----------------VKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
+ R ++L E++ L Q L E+ + K ELL RE+ + LE+ + N
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKT--KTDELLALGREKGNEILEL---------KCN 225
Query: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS---ESLSELIT-LREAL 549
+E +KEE RL+E + GL+ + + +L+T L+EA
Sbjct: 226 LE---------NKKEEVS-----------RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAK 265
Query: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEAL 608
E E E L+ +S A+ S ++ N L V +L + N+A+
Sbjct: 266 EQQASMEEKFHNE-LNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAI 324
Query: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
+ + Q Q+E+E R+E + N DL A KR+ A+ + L A
Sbjct: 325 QDHLLEVEQSKDQMEKEMLEKIGRLEKELENAN----DLLSATKRKGAILSEE-ELAAMS 379
Query: 669 QKAEEAGAELQADLR--DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR 726
A ++ ++ ++ E Q +L + + + L+++ +E + + +L R
Sbjct: 380 PTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKR 439
Query: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786
+E E + A+L V+L+ ++ Q L E +A +Q+SV+E
Sbjct: 440 QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTD--------------KANKQSSVLERD 485
Query: 787 KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER-SQAEQERDAAARQLAQAEQEGKTALE 845
++E+Q++ ++Q ++R L +EL+ R + ++ + ++ ++ + + L
Sbjct: 486 NRRMEIQVKDLSQ-------QIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLV 538
Query: 846 QQKAAHE------------KEVNQLREKWEKERSWHQ-QELAKALESLEREKMELEMRLK 892
+ E +E+ + RE+ E+E + + EL LES E +L +
Sbjct: 539 SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQ 598
Query: 893 EQQTEMEAIQAQREEERTQAE-----------SALCQMQLETEKERVSLLETL------- 934
Q +++I QR+ R S+L + L + +R S +T+
Sbjct: 599 HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVP 658
Query: 935 LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
+ E +A L++L++ + K ++ E I QL++ Q ++ + Q+ L
Sbjct: 659 VIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQL 718
Query: 995 QEESS--SLLQDKMDLQKQ----VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048
S +LQD ++ ++ + + +L A Q + + + LR E + +
Sbjct: 719 DFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778
Query: 1049 ----ELEREKASLTLS---LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE-LS 1100
L++EK L LS L ++ + LL Q ++ L ++ ++ ++ E K+ LS
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLS 838
Query: 1101 AQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
+Q+E L E+ + +L E+E H + L L + R TE
Sbjct: 839 SQIEKLEHEISHLKK-------KLENEVEQRHTLTRNLDVQLLDTK--------RQLDTE 883
Query: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG------DSAPSVW 1214
+ L E AQ ++A+L L V + +G G D V
Sbjct: 884 TNLHLNTKELLKN----AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 1215 GLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLT 1274
L + L +R T+ + E + + L + L K +Q + +R + +E RL
Sbjct: 940 QLRQTEEQVNDLKERLKTSTS-NVEQYQAMVTSLEESLNKEKQVTEEVR---KNIEVRLK 995
Query: 1275 DTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAEL 1334
++ ++Q+ +L +++++ + Q++K + S+E +L EL +T++S+Q+ ++ A L
Sbjct: 996 ESAEFQTQLEKKLMEVEKEKQELQDDKRR---AIESMEQQLSELKKTLSSVQNEVQEA-L 1051
Query: 1335 QRM------EAQGERELLQAAKENLTAQ-------------VEHLQAAVVEARAQASAAG 1375
QR E Q R+ + AK + AQ VE LQAA + AS
Sbjct: 1052 QRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQ 1111
Query: 1376 ILEEDLRTARSAL-----------KLKNEEVESERERAQALQEQGELKVAQGKALQENLA 1424
LEE + A S L ++ +EV R + L++Q L Q + L + +
Sbjct: 1112 HLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV 1171
Query: 1425 L---------LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
L +L+E + E + ++ + +++E+ + E+ ++ + Q V+L
Sbjct: 1172 ASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL 1231
Query: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL---ELE 1532
+ ++QEL+ + A +E+ Q Q EL K ET V+E + E E
Sbjct: 1232 ERELQELQDSLN-------AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE------------LE 1580
+ +Q ++ + +V+ L+ ++ L+ EL E ++ ++KL++E +
Sbjct: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
Query: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Q++ L + E ++ +Q + +I L++ L ++S +E +
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Query: 1641 ELQRQKEHLTQDLERRDQELMLQKERI-QVLEDQRTRQTKILEEDLEQIKL---SLRERG 1696
+++ +KE + +DL+ + ++ + + I QV + R +T+ E +Q K+ S + G
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 1697 --RELTTQRQLMQERAE---EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQEL 1751
+E Q MQE E + + SK+ +E+++ L +KE E QE +LQ
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSE 1524
Query: 1752 KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA 1811
+L Q LQ + + Q Q+I +++ ++A + K L D+ +
Sbjct: 1525 LSRLRQDLQ-------DRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKE 1577
Query: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ 1867
+ Q AL Q++ + + +K + + LE+ +ERH E +D ++
Sbjct: 1578 NEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
Score = 202 bits (513), Expect = 4e-51
Identities = 367/1708 (21%), Positives = 708/1708 (41%), Gaps = 206/1708 (12%)
Query: 488 RLRRVNVELQLQGDSAQGQKEE---QQEELHLAVRER-ERLQEMLMGLEAKQSESLSELI 543
+L + + Q + D +G+ E+ + E+ + + +R QE L+ E ++ +SL
Sbjct: 24 KLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVN-ETRECQSL---- 78
Query: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
R LE + + + L ++ E+ A R ++ + ++ L+ E DL +LS
Sbjct: 79 --RLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
Query: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
E L D LN++L + + +++ + + +++ E+ +E L +NT
Sbjct: 137 ELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTW 196
Query: 664 LEAQLQ-KAEEA---GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
L +L+ K +E G E ++ +++ E ++++S Q T E L K
Sbjct: 197 LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ---KH 253
Query: 720 QEEVLARAVQEKE--ALVREKAALE----VRLQAVERDRQDLAEQLQG-LSSAKELLESS 772
E++L + + KE A + EK E ++L + + D +E L+ A E L
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL 313
Query: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
L EA + N I+ + V Q+K+ ++ E+ L+ E A A R+
Sbjct: 314 LKEAGEANKAIQD-------HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
Query: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME--LEMR 890
A +E A+ AA K V + E ++ + + LE LE +++ L+
Sbjct: 367 GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 891 LKEQQTEMEAIQAQREE-ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
+KE + + ++ QREE ER Q A ++LE + + L Q++ A++Q
Sbjct: 427 VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL------QEDTDKANKQSS 480
Query: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009
L +D + +++ ++ L Q++ EL+EA H EE SS D+
Sbjct: 481 VLERDNRRMEIQVKD----LSQQIRVLLMELEEARGNH----VIRDEEVSSA-----DIS 527
Query: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
E + LV S R +E+ Q+ R + + ERE+ T S + + Q L
Sbjct: 528 SSSEVISQHLV----SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ--L 581
Query: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129
L+ A + EL LR+ Q + Q ++ R + + + A L+++
Sbjct: 582 KLESALT----ELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVS 637
Query: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA--------EQQPGNQAQAQAQ 1181
+ ++ + + A ++ STE+ +EA AA E +A+ +
Sbjct: 638 LASTPKRPSTSQTVSTPAPVPVIE----STEA-IEAKAALKQLQEIFENYKKEKAENEKI 692
Query: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQ-NGAR----SLFKRGPLLTAL 1236
LQ+ + + ++S D A + + D G R SL +R LTA
Sbjct: 693 QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA- 751
Query: 1237 SAEAVASALHKLHQDLWKTQQ---TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR- 1292
+ + ++ + QDL + +V + ++K +E L +E SQ L QR
Sbjct: 752 TTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 1293 --------QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL-----------RRAE 1333
Q Q E+S+ E KQ L S++ +L ++ L+ +L R +
Sbjct: 812 QNLLLTNLQTIQGILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD 870
Query: 1334 LQRMEAQGE-----------RELLQAAKENLTAQVEHLQAAVVEARAQAS-----AAGIL 1377
+Q ++ + + +ELL+ A++ + +HL V+ +Q+S
Sbjct: 871 VQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSN 930
Query: 1378 EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
+ED+ S L+ E+V +ER + E A +L+E+L Q E + +
Sbjct: 931 KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNI 990
Query: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKK-RNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
E + E + Q E + +E +L+ + + ++ ++Q+ EL+K S +++ V
Sbjct: 991 EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN---EV 1047
Query: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
QE Q+ + ++ +D + Q + + E++ + + +Q K+Q+ +
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
Query: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD-LE 1615
+ LEE K E Q + E + E + L R ++L+ Q+ +HD +E
Sbjct: 1108 SVRQHLEETTQKAESQ---LLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIE 1164
Query: 1616 SHSTVLARELQERDQ---------EVKSQREQIEELQ---RQKEHLTQDLERRDQELMLQ 1663
S + ++E Q E KSQ + +E L+ R+KE E E +
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
Query: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR--ELTTQRQLMQERAEEGK---GPSK 1718
++R+++LE + L + E+++++ + + EL + + M E K +
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV----GETSLLLS 1774
L+ M+ +R E ++ QE EL E L+ + + L V L+S
Sbjct: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
Query: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL-------EALQQEQQ 1827
Q++ ++L +E + Q L ++ + +A+ + L ++L+++
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Query: 1828 QAQGQEERVKEKADALQGALEQAHMT-----------------LKERHGELQDHKEQARR 1870
+ + ++E +++ DA +++ T LK + ++ + Q+
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
+E V + +Q L+E L +S+ E + LQ+ +E+ E E R LQ+ +Q
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEK----ETEARNLQEQTVQ 1520
Query: 1931 AQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
Q+ EL LR + Q QEE R + +E KA A + K HL
Sbjct: 1521 LQS-------ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHL------ 1567
Query: 1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050
A ++ L +Q AL Q+ E+ D+R Q + +++ + E
Sbjct: 1568 --------AGVKDQLTKENEELKQRNGALDQQKDEL---DVRITALKSQYEGRISRLERE 1616
Query: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQ 2078
LR QER LE+ + N + E+Q
Sbjct: 1617 LREHQERH--LEQRDEPQEPSNKVPEQQ 1642
Score = 174 bits (442), Expect = 7e-43
Identities = 334/1629 (20%), Positives = 657/1629 (40%), Gaps = 222/1629 (13%)
Query: 14 QSLQLVLEE---QVLALQQQMAENQAASWRKL---------KNSQEAQQRQATLVRKLQA 61
QSL+L LE+ Q+ AL ++ E + A R + K EA++R + +
Sbjct: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
Query: 62 KVLQYRSW-CQELEKRLEATGGPIPQRWENVEEPNLDELLV-----RLEEEQQRCESLAE 115
+ L+Y + + L ++L+ + + ++E ++ V RLE+E++ S
Sbjct: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNT 195
Query: 116 -VNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEH 174
+NT+L+ ++ + + ++ +L + ++E+ R E Q LK +
Sbjct: 196 WLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG--------LKTSN 247
Query: 175 GRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNG 234
L +++T + E +++ + H++LS L A
Sbjct: 248 EHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN--------LYKSAADDSEAK 299
Query: 235 SGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQ 294
S + R +L LL + E K + E+ Q K Q + E E R+
Sbjct: 300 SNELT-RAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL--------- 349
Query: 295 SQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV----IKDITQ 350
+K+ E+ ++ A + IL M A+ + + L ++ ++ Q
Sbjct: 350 -EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
Query: 351 VMVEEGDNIAQGSGHEN---SLELDSSIFSQF--DYQDADKALTLVRSVLTRRRQAVQDL 405
+++E+ +N + +E + I + +Y+ A KA+ + L + + +Q L
Sbjct: 409 LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL 468
Query: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS--LSK 463
++ + ++L++ + + E + K L Q+++ L E + G V EV S +S
Sbjct: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
Query: 464 ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE----ELHLAVR 519
E++ + R +E L+Q+ RL V L+ G++ + +++E EL L +
Sbjct: 529 SSEVISQHLVSYRN-IEELQQQNQRLL---VALRELGETREREEQETTSSKITELQLKLE 584
Query: 520 ERERLQEMLMGLEAKQSESLSELITLREAL-----ESSHLEGELLRQEQTEVTAALARAE 574
E L Q + + ++ R+ +++ + L +V+ A
Sbjct: 585 SALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKR 644
Query: 575 QSIAELSSSENTL----KTEVADLRAAAVKLSALNEALALDKVG-----------LNQQL 619
S ++ S+ + TE + +AA +L + E +K L +Q+
Sbjct: 645 PSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQV 704
Query: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQ 679
L +N + ++++ A + LQ ++ + +L E+N L A QK E+ +
Sbjct: 705 TDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMT 764
Query: 680 ADLRDIQEE------------KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA 727
DLR E+ KE+ KLSE R Q+ + EQ Q +
Sbjct: 765 QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG 824
Query: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
+ E+ K L +++ +E + L ++L+ + L +L + + TK
Sbjct: 825 ILERSE-TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL------DVQLLDTK 877
Query: 788 GQLEVQIQTVTQAKEVI---QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
QL+ + KE++ Q E+ LK L Q + + + +E L
Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
Query: 845 EQQKAAHEKEVNQLREKWEKERS---WHQQELAKALESLEREKM-------ELEMRLKEQ 894
Q E++VN L+E+ + S +Q + ESL +EK +E+RLKE
Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
Query: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954
Q Q E++ + E ++Q + + S+ + L + +K L+ +++ Q
Sbjct: 998 AE----FQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 955 MKVQKLKEQETTGILQTQLQ---EAQRELKEAARQHRDDLAALQ---EESSSLLQDKMDL 1008
EQ+ Q Q + EAQ + + H D+ ALQ E+ S + + L
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 1009 QKQVEDLKSQLV----AQDDSQRLVEQEVQE---KLRETQEYNRI-QKELEREKASLTLS 1060
++ + +SQL+ + ++ +R+++ EV + + + ++ NR+ ++E+ + S
Sbjct: 1114 EETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVAS 1173
Query: 1061 LMEKEQRLL--VLQEADSIRQQELSALRQDMQE----------AQGEQKELSAQMELLRQ 1108
+ E Q L L E ++Q L LR +E AQ E ++ELL +
Sbjct: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLER 1233
Query: 1109 EVKEKE-------------ADFLAQEAQLLEELEASHI---TEQQLRASLWAQEAKAAQL 1152
E++E + A +AQ +L+++ E ++ T + LR E Q+
Sbjct: 1234 ELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQM 1293
Query: 1153 QLRLRSTESQL----EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGD 1208
Q ++R E + EA A + QA+ +L +A S+ + +
Sbjct: 1294 QAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEE 1353
Query: 1209 SAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA------LHKLHQDLWKTQQTRDVL 1262
+ E + L + L A A + AS + L +DL K + ++ +
Sbjct: 1354 YRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETI 1413
Query: 1263 RD-----------------QVQKL--------------EERLTDTEAEKSQVHTELQDLQ 1291
+ QV+K+ ++++ +T A+ S H E
Sbjct: 1414 QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSV 1473
Query: 1292 RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE 1351
+++ + +E ++ E K SLES++ L +T++ ++ R + Q ++ Q E L+ +
Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ 1533
Query: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411
+ T Q E L+ + E EE R A A K K + ++ Q +E EL
Sbjct: 1534 DRTTQEEQLRQQITEK----------EEKTRKAIVAAKSKIAHLAGVKD--QLTKENEEL 1581
Query: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-REMQKAALELLSLDLKKRNQ 1470
K G Q+ L + A + + G+I LE++ RE Q+ LE + ++ +
Sbjct: 1582 KQRNGALDQQKDELDVRITALKSQ----YEGRISRLERELREHQERHLEQRD-EPQEPSN 1636
Query: 1471 EVDLQQEQI 1479
+V QQ QI
Sbjct: 1637 KVPEQQRQI 1645
Score = 174 bits (440), Expect = 1e-42
Identities = 332/1659 (20%), Positives = 667/1659 (40%), Gaps = 255/1659 (15%)
Query: 873 LAKALESLEREKM------ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926
L + LE E K+ +LE L +QQ+E++ ++ + E+ + ++E Q E EK
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE----QQYFEIEKR 60
Query: 927 RVSLLETLLQTQKELADASQQLERLRQDMKV--QKLKE----QETTGILQTQLQEAQREL 980
E L+ +E +LE+L +K +K KE Q+ +Q+Q + EL
Sbjct: 61 LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120
Query: 981 KEAARQHRDDLAALQEESSSLLQD--------------KMDLQKQVEDLKSQLVAQDDSQ 1026
+ R L +E L +D K +LQ ++++L++ V+ +
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086
+ +EQE +E L + + EL+ + L EK +L L+ +++E+S L
Sbjct: 181 KRLEQE-KELLHSQNTW--LNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLE 237
Query: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
+ M + + L +E L ++KE + + E + EL A +++ E
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE 297
Query: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206
AK+ +L R+ E +L L E N+A +Q L V +S+ ++
Sbjct: 298 AKSNELT---RAVE-ELHKLLKEAGEANKA------------IQDHLLEVEQSKDQMEK- 340
Query: 1207 GDSAPSVWGLEPDQNGARSLF----KRGPLLTALSAEAV---ASALHKLHQDLWK-TQQT 1258
+ + LE + A L ++G +L+ A+ A+A+ K+ + K T+
Sbjct: 341 -EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
Query: 1259 RDVLRDQVQKLEERLTDTEAEK--SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM 1316
+ Q Q L E+L + K ++ E++ L + +EE + + SL +L
Sbjct: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA------- 1369
+ + + LQ +A Q + + ++ ++L+ Q+ L + EAR
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
Query: 1370 QASAAGILEEDLRTARSALKLKN-EEVESERERAQ-ALQEQGELKVAQ-----GKALQEN 1422
+ S+A I ++ + +N EE++ + +R AL+E GE + + + E
Sbjct: 520 EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITEL 579
Query: 1423 LALLTQTLAEREEEVETLRGQIQELE---KQREMQKAALE-------------LLSLDLK 1466
L L E E+ ++ + Q+Q ++ +QR+M + L L + L
Sbjct: 580 QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639
Query: 1467 KRNQEVDLQQ-----------------EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
+ Q E L++ + + E+ E E+ Q E+
Sbjct: 640 STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699
Query: 1510 IRELEKDRETQRNVLEHQLLELEKKDQM----IESQRGQVQDL-----------KKQLVT 1554
++E D +Q + QL K+ +M +E R ++ L +KQ
Sbjct: 700 LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759
Query: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614
+ + +L + K+ + + L+ ++E +++ L+ E E + Q+ + +L
Sbjct: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
Query: 1615 ESHSTVLARELQERDQEVKSQREQIE-ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ 1673
++ +L R E Q + SQ E++E E+ K+ L ++E+R + + +Q+L+ +
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR--HTLTRNLDVQLLDTK 877
Query: 1674 RTRQTKILEEDLE-QIKLSLRERGRELTTQRQLM---------QERAEEGKGPSKAQRGS 1723
R T E +L K L+ +E+ T +Q + Q GKG + +
Sbjct: 878 RQLDT---ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG-QPSNKED 933
Query: 1724 LEHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQL-----------QGLHRK 1765
++ + LR E++V +E ++ + Q + LE+ L + + +
Sbjct: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
Query: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE----- 1820
+ E++ +Q E++++ ++++ QE ++ +S++ QL E ++ L+ E++
Sbjct: 994 LKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQR 1053
Query: 1821 ---ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
AL EQQ + +E+ K +A Q E+ M LQ KEQ ++
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEA-QNKYERELMLHAADVEALQAAKEQVSKMASVRQH 1112
Query: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW--LQAQAVL 1935
Q E L + +A E+E+ L +C + ++ E + R L D L + V
Sbjct: 1113 LEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVA 1172
Query: 1936 ------------------KERDQELEALR-----------------AESQSSRHQEEAAR 1960
K ++Q LE LR ES R + E
Sbjct: 1173 SVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLE 1232
Query: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
+ LQ++L +Q + + + EL + E ++ + + +LE+ L+
Sbjct: 1233 RELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETN-KMLREEKERLEQDLQ 1291
Query: 2021 IQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNL 2080
+ +++ +L D+ LQ+A A+ E+ Q ++LLE+ + + N Q
Sbjct: 1292 QMQAKVRKLEL----DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ- 1346
Query: 2081 GQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK 2140
++ + EE R L + Q +EI L+ R+N + + ++E K
Sbjct: 1347 -KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNK 1405
Query: 2141 LDSLEPRLQRELERLQAALRQ-----TEAREIEWREKAQ--------------------- 2174
+ + + +Q++L+ +++ T+ ++I R K Q
Sbjct: 1406 VRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGD 1465
Query: 2175 ------------DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL 2222
+L +L Q + SL+ LQ ++ E+++E + LQ++ + L
Sbjct: 1466 HQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSEL 1525
Query: 2223 EKERLHSPGATSTAE----LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQA 2278
+ R T+ E + E+ + V+ G++ Q ++ E L+Q
Sbjct: 1526 SRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN-EELKQR 1584
Query: 2279 VARLEIDRSRLQRHNVQLRSTLE-QVERERRKLKREAMR 2316
L+ + L L+S E ++ R R+L+ R
Sbjct: 1585 NGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Score = 143 bits (360), Expect = 2e-33
Identities = 253/1251 (20%), Positives = 519/1251 (41%), Gaps = 198/1251 (15%)
Query: 1314 ELMELHETMASLQSRLRR------AELQRMEAQGERELLQAAKE--NLTAQVEHLQAAVV 1365
E EL++ S+Q++L + +E+ ++ + E+ +++ ++ + ++ H Q +V
Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLV 69
Query: 1366 EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ-----GELK------VA 1414
+ + + E L AL KN+E+E ++R A+Q Q EL+ +
Sbjct: 70 NETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIR 129
Query: 1415 QGKALQENLALLTQ---TLAEREEEVETLRGQIQ----EL----------EKQREMQKAA 1457
+ L + L LT+ L E+ +E T +G++Q EL EK+ E +K
Sbjct: 130 TNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
Query: 1458 L----------------ELLSLDLKKRNQEVDL------QQEQIQELEKCRSVL----EH 1491
L ELL+L +K N+ ++L ++E++ LE+ + L EH
Sbjct: 190 LHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEH 249
Query: 1492 LPMAVQEREQKLTVQREQIRELEK---------------------DRETQRNVLEHQLLE 1530
L V++ KL +EQ +E+ D E + N L + E
Sbjct: 250 LQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEE 309
Query: 1531 LEK------------KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK---L 1575
L K +D ++E ++ + Q K+ L + L ELE + + ++ +
Sbjct: 310 LHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAI 369
Query: 1576 IKELEGQRETQRVA-----------LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE 1624
+ E E + A LT L E +L + + + + + +E
Sbjct: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429
Query: 1625 LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684
++ + +K QRE+ E Q+ L+ LE+ +E+ +R+Q D+ +Q+ +LE D
Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI----QRLQEDTDKANKQSSVLERD 485
Query: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
++++ + ++L+ Q +++ EE +G ++RD+E
Sbjct: 486 NRRMEIQV----KDLSQQIRVLLMELEEARG------------NHVIRDEEVSSA----- 524
Query: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804
++ + + Q L +R + E L Q+ Q ++V ++L E RE+ E +++ S+
Sbjct: 525 --DISSSSEVISQHLVS-YRNIEE----LQQQNQRLLVALRELGETREREE--QETTSSK 575
Query: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
+ E Q L ELE L++ +Q + + + D + L Q H D
Sbjct: 576 ITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDD 635
Query: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
A + + A V+ A + KA L Q+ E ++ + E +
Sbjct: 636 VSLASTPKRPSTSQTVSTPAPVPVIESTEA---IEAKAALKQLQEIFENYKKEKAENEKI 692
Query: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984
Q+ L+ + +++ LR+++ Q + A R E LQ+ ++G + +
Sbjct: 693 QNEQLE------KLQEQVTDLRSQNTKISTQLDFASKRYEMLQD-------NVEGYRREI 739
Query: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
E ++ L A+T + ++ R E L + E++ ++L+ ++++ +L
Sbjct: 740 TSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAV--AEVRAENLKKEKEMLKL---- 793
Query: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104
E+R Q+RE LL + Q + +Q Q + + E E + L + +L+ ++
Sbjct: 794 ----SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEIS 849
Query: 2105 QKEQEI---LELRETQQRN-NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR 2160
++++ +E R T RN +++ L + L L Q+E+ L+ L
Sbjct: 850 HLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS 909
Query: 2161 QTEAR------------EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQ 2208
E + + +E DL L QT+ V+ L+E ++V + +
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMV 969
Query: 2209 QRLQDELELTRRALEKERLH-SPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK-Q 2266
L++ L ++ E+ R + +AE ++ E+ +L EV + E D +
Sbjct: 970 TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK--KLMEVEKEKQELQDDKRRAIE 1027
Query: 2267 SWRQRLEHLQQAVARLEID-RSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI 2325
S Q+L L++ ++ ++ + + LQR + L S +Q R+ ++ + A+ A E+
Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRASTAL-SNEQQARRDCQEQAKIAVEAQNKYEREL 1086
Query: 2326 SKATASSPTQQDGRGQKNSDAKCVAELQK-----EVVLLQAQLTLERKQK--QDYITRSA 2378
A Q + Q + A L++ E LL+ + + E +++ +D +++
Sbjct: 1087 MLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
Query: 2379 QTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVL 2429
+L + L + ++ A+V E L+ SL++ S +L
Sbjct: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL 1197
Score = 116 bits (291), Expect = 2e-25
Identities = 206/1005 (20%), Positives = 426/1005 (42%), Gaps = 109/1005 (10%)
Query: 10 NMKPQSLQLV-LEEQVLALQQQ------MAENQAASWRKLKNSQEAQQRQATLV----RK 58
N K Q+ QL L+EQV L+ Q + + + L+++ E +R+ T + +K
Sbjct: 689 NEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQK 748
Query: 59 LQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEE---EQQRCESLAE 115
L A + + + L + E ++ +++L E QQR LAE
Sbjct: 749 LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAE 808
Query: 116 VNTQ--LRLHMEKAD-VVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
Q L +++ ++ ++ E ++L+ + E+ + + + E E +
Sbjct: 809 QRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRN 868
Query: 173 EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREP 232
+LL R++ T L K E+ LS + + V +QS +
Sbjct: 869 LDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSN------MEVQVASQSSQR 922
Query: 233 NGSGRMDGREPAQ-LLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSAL 291
G G+ +E L+ L +T+E + ER + S ++E + Q VT L
Sbjct: 923 TGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKT-----STSNVE--QYQAMVTSLEES 975
Query: 292 LTQSQKQNEDYEKMIKA-LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350
L + ++ E+ K I+ L+E+ E +LME E +++ +++ + + +++
Sbjct: 976 LNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSE 1035
Query: 351 VM--VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRR-------QA 401
+ + N Q + S L + ++ D Q+ K ++ R +A
Sbjct: 1036 LKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA 1095
Query: 402 VQDLRQQLAGC-----------QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQ 450
+Q ++Q++ Q+A + L + WEE + L+ + K + L Q
Sbjct: 1096 LQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQ 1155
Query: 451 TVDLQGEVDSLSKE-----RELLQ-----KAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
L +++ LS + +E +Q EE + Q ++LE + +RR + +
Sbjct: 1156 NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRF-IRREKEIAETRF 1214
Query: 501 DSAQGQKEEQQEELHLAVRERERLQEML------MGLEAKQSESLSELITLREALESSHL 554
+ AQ + ++ + L RE + LQ+ L + + AK EL+ E +
Sbjct: 1215 EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVME 1274
Query: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
++LR+E+ R EQ + ++ + L+ ++ L+ A +LS + L +K
Sbjct: 1275 TNKMLREEKE-------RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL 1327
Query: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAE-KRREALWEKNTHLEAQLQKAEE 673
L + + + + NQ + S+ + + + E KR + L E+ L+A++ ++
Sbjct: 1328 LEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNA 1387
Query: 674 AGAE-------LQADLRDIQEEKEEIQKKLSESR---HQQEAATTQLEQLHQEAKRQEEV 723
+ L+ DL ++ EKE IQK L ++ TQ++++ + K Q E
Sbjct: 1388 SLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 724 LARAVQEKEALVREKAALEVRLQAVE-RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSV 782
L +A Q+K +++ + + Q V ++ Q+L E L + + LES + Q+
Sbjct: 1448 L-KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQK---- 1502
Query: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
T + E + + + + +Q E+ L+ +L +Q EQ R +Q+ + E++ +
Sbjct: 1503 ---TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLR----QQITEKEEKTRK 1555
Query: 843 AL--EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
A+ + K AH V +++ KE +EL + +L+++K EL++R+ +++ E
Sbjct: 1556 AIVAAKSKIAHLAGV---KDQLTKEN----EELKQRNGALDQQKDELDVRITALKSQYEG 1608
Query: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
++ E E + + + + E ++ + E Q + AS
Sbjct: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPAS 1653
Score = 112 bits (281), Expect = 3e-24
Identities = 191/914 (20%), Positives = 390/914 (42%), Gaps = 123/914 (13%)
Query: 2 ETRSPGLNNMKPQSLQLVLE------EQVLALQQQMAENQAASWRKLKNSQEAQQRQATL 55
E R L Q++Q +LE +Q L+ Q + E++ + +K K E +QR TL
Sbjct: 808 EQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKK-KLENEVEQRH-TL 865
Query: 56 VRKLQAKVLQYRSWC----------QELEKRLEATGGPIPQRWENVE------------- 92
R L ++L + +EL K + + Q N+E
Sbjct: 866 TRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGK 925
Query: 93 -----EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDV--EKLTVDW 145
+ ++D+L+ +L + +++ L E ++E+ + +L E + EK +
Sbjct: 926 GQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEE 985
Query: 146 SRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMEL 205
R E+ KES + + + K ++ E + +E+ +R +E + ++ L EL
Sbjct: 986 VRKNIEVRLKESA-EFQTQLEKKLMEVEKEK-----QELQDDKRRAIE---SMEQQLSEL 1036
Query: 206 KAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQ 265
K + + R + + + R D +E A++ + E E H
Sbjct: 1037 KKTLSSVQNEVQEALQRASTALSNEQ---QARRDCQEQAKIAVEAQNKYERELMLHAADV 1093
Query: 266 ELIQLKSQGDLEKAELQDRVTELS----ALLTQSQKQNEDYEKMIK-ALRETV---EILE 317
E +Q + + A ++ + E + + L + + E+ E+M+K + + V E LE
Sbjct: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE 1153
Query: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFS 377
+ L + LS + S+++ ++ V + E +G E LE+ I
Sbjct: 1154 KQNRLLHDQIEKLS---DKVVASVKEGVQGPLNVSLSE-----EGKSQEQILEILRFIRR 1205
Query: 378 QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL 437
+ + + + V S+ R RQ V+ L ++L Q+++N +++ Q + A + L
Sbjct: 1206 EKEIAETRFEVAQVESL--RYRQRVELLERELQELQDSLNA-EREKVQVTAKTMAQHEEL 1262
Query: 438 QKLTGERDTLAGQTVDLQGEVDS-LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
K T +T+++ E + L +E+E L++ ++++ ++ LE + L+ N EL
Sbjct: 1263 MKKT--------ETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
Query: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA----LESS 552
+ Q +K+ +E++ R + R Q ++ + +E +L++ +E ++
Sbjct: 1315 SEKSGMLQAEKKLLEEDVK---RWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQL 1371
Query: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA----DLRAAAVKLSALNEAL 608
E L+ E A+L + I L N ++TE DL A + + + +
Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI 1431
Query: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQ---VDLAEAEKRREALWE---KNT 662
K + Q EE ME + Q+ Q V + E ++ +E L + K+
Sbjct: 1432 TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK 1491
Query: 663 HLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722
LE+Q++ ++ +E + + R++QE+ ++Q +LS R + TTQ EQL Q+ +EE
Sbjct: 1492 SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
Query: 723 VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSV 782
+ ++A+V K+ ++ L+ K+ L E +Q+N
Sbjct: 1552 ------KTRKAIVAAKS------------------KIAHLAGVKDQLTKENEELKQRNGA 1587
Query: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA-EQEGK 841
++ K +L+V+I T K +G + L+ EL + + ++RD + EQ+ +
Sbjct: 1588 LDQQKDELDVRI---TALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
Query: 842 TALEQQKAAHEKEV 855
L+ A+ E+ +
Sbjct: 1645 ITLKTTPASGERGI 1658
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 228 bits (581), Expect = 6e-59
Identities = 490/2513 (19%), Positives = 1002/2513 (39%), Gaps = 430/2513 (17%)
Query: 25 LALQQQMAENQAASWRK-----------------------------------LKNSQEAQ 49
L Q+++A+N S K L+ ++A
Sbjct: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAG 77
Query: 50 QRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWEN---VEEPNLDELLVRLEEE 106
+ QA +L+ KV++ + ELE ++ GG + N E L++ LE+
Sbjct: 78 EEQAKFENQLKTKVMKLEN---ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDM 134
Query: 107 QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKL----------TVDWSRARDELMRKE 156
++ E +VN QL L E+A+ N LR + ++L +D+ + D
Sbjct: 135 EKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETL 194
Query: 157 SQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR-------HFLEMKSATDRDLMELKAEH 209
+ E ++ L ++ L+ E+ T EM+ + + E++
Sbjct: 195 LSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMT 254
Query: 210 VRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL------------LLLAKTQELE 257
+ V Q ++ N ++ +E LL + AK +E +
Sbjct: 255 DEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK 314
Query: 258 KEAHERSQELIQLKS-----QGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRET 312
+ E+I+ + + L+ A+L + + AL Q+++ + + + + +
Sbjct: 315 LILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQY 374
Query: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIK-----DITQVMVEEGD---NIAQGSG 364
+ +E N + + + L RN LS Q +K DI + +E + +A+
Sbjct: 375 TKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADA 434
Query: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424
E EL ++ DY+ L + + ++ +++ + +N L+ +
Sbjct: 435 REKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS 494
Query: 425 QWEEEGKALRQR-------LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477
+ +E +ALR+R + LT R++ + + E L KE E L++ R +L++
Sbjct: 495 DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKK 554
Query: 478 QLEVLEQEAWRLRRVN----VELQLQGDSAQGQK-----------------EEQQEELHL 516
++ + QE + + +L L + +QG + + + E L
Sbjct: 555 KIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSR 614
Query: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE-GELLRQEQTEVTAALARAEQ 575
+ E+ER E + AK L EL+ + LE E + +++ Q +
Sbjct: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
Query: 576 SIAELSSSENTLKTEVAD--------LRAAAVKLSALNEAL-------ALDKVGLNQQLL 620
I L N ++++ A+ L+A +L+ NE L + + +QQL
Sbjct: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLA 734
Query: 621 QLE------EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
+ E+ S+ + E + + + A + +N +L LQ+ E
Sbjct: 735 KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENK 794
Query: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
+ L+++++ E+ +K + RHQQ L++E ++E E + +
Sbjct: 795 ----EKKLKNLEDSLEDYNRKFAVIRHQQSL-------LYKEYLSEKETWK---TESKTI 840
Query: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
EK LE ++Q ++ L L + ++ L E ++ +V++V +
Sbjct: 841 KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE------- 893
Query: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE 854
K +I+ ++LE + +Q+ + + + E+ G L++ K +
Sbjct: 894 ------KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG--CLQRFKEMAIFK 945
Query: 855 VNQLREKWEKERSWHQQELA----KALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
+ L++ + S + ELA L + R+ ++ + L ++ + +E ++ + +
Sbjct: 946 IAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKE 1005
Query: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK--EQETTGI 968
Q ES +LE KE++ +E + + +L + S +++ ++ + + ++ T +
Sbjct: 1006 QVES--INKELEITKEKLHTIEQAWEQETKLGNES-SMDKAKKSITNSDIVSISKKITML 1062
Query: 969 LQTQLQEAQR---------ELKEAARQHRDDLAALQEESSSLLQDKMDLQK-------QV 1012
+L E QR L+ + +Q + L+ + + L + +D QK ++
Sbjct: 1063 EMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDEL 1122
Query: 1013 EDLKSQLVAQDDSQRLVEQEVQE--------KLRETQEYNRIQKELEREKASLTLSLMEK 1064
D S+ V+ D QR++E E E KLRE + R Q E+ + +E
Sbjct: 1123 ADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVES 1182
Query: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
+ L+ +A S + ++ L Q Q + ++E + ++++ EA L E +L
Sbjct: 1183 LRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL 1242
Query: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL--AAEQQPGNQAQAQAQL 1182
E+ EQ L + +A L+ ++S Q A+Q+ ++ Q Q
Sbjct: 1243 DEK-------EQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN 1295
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE------PDQNGARSLFKRGPLLTAL 1236
L +Q+ S E R + + + GLE D GA+ + + L
Sbjct: 1296 DKL-KIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEEL 1354
Query: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE---KSQVHTELQ----- 1288
+ + KL+++L K ++ L + + + E ++ E E +++ H E Q
Sbjct: 1355 RLQEL-----KLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ 1409
Query: 1289 ---DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
DL+RQL ++++ E + + L ++L A
Sbjct: 1410 REVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA------------- 1456
Query: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE------- 1398
L+ KEN+ ++E RA + LEE L+ SAL+L + + S
Sbjct: 1457 LRKIKENI--------RIILETRATCKS---LEEKLKEKESALRLAEQNILSRDKVINEL 1505
Query: 1399 RERAQALQEQGELKVAQGKALQE-----NLALLTQTLAERE----EEVETLRGQIQELEK 1449
R R A E+ +L G+ E L + QT+A + ++ E L+ + LEK
Sbjct: 1506 RLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEK 1565
Query: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV--------------------L 1489
RE Q+ ++ DL + ++LQ + L K + L
Sbjct: 1566 AREEQREIVKKHEEDLHILHHRLELQAD--SSLNKFKQTAWDLMKQSPTPVPTNKHFIRL 1623
Query: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK-KDQMIESQRGQVQDL 1548
+ V E++ L+ +++++ +D E QR + E ++ E E K Q+ E+ +V+ +
Sbjct: 1624 AEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKV 1683
Query: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
K ++ L+ L L+++ + +C L EL+ Q+E A T +L ER +
Sbjct: 1684 KAEVEDLKYL---LDQSQKESQC---LKSELQAQKEANSRAPTTTMRNLVERLK------ 1731
Query: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQ--IEELQRQKEHLTQDLERRDQELMLQKER 1666
SQ+ E L+R L E E+ + E+ I +++ HL
Sbjct: 1732 SQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL----------------N 1775
Query: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
+Q + D+ TR+ K EDL + L L+E + + + + + ++ Q+ +
Sbjct: 1776 VQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLN--NELQKKQKAY 1833
Query: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK--VGETSLLLSQREQEIVVLQ 1784
K ILR+KE E QE+ ELK Q+++ GL K L+ + ++++ L+
Sbjct: 1834 NK-ILREKE---EIDQEN----DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
Query: 1785 QQLQEAREQGELKE----------------QSLQSQLDEAQRALAQRDQELEALQQEQQQ 1828
QL+ E+ +LK + Q++++ + L +++ E+ L ++
Sbjct: 1886 NQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT 1945
Query: 1829 AQGQEERVKEKADALQGALEQAHMTLK--------ERHGELQDHKEQARRLEEE-LAVEG 1879
+ + ++ LQ L+ MT+ E EL++ K++ LE + L +
Sbjct: 1946 LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
Query: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
+ + V+ DL ++R ++ L AL++Q ++ + D Q + L++ +
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKEN 2065
Query: 1940 QEL--EALRAESQSSRHQEEAARARAEA-----LQEALGKAHAALQGKEQHLLEQAELSR 1992
+L E + + Q + ++ R + + + E L K A +Q K H+ +
Sbjct: 2066 LKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGK 2125
Query: 1993 S---LEASTATLQASLDACQAHSRQLEEALRIQEGE----IQDQDLRYQEDVQQLQQALA 2045
+ LE + ++ ++ Q + QL++A I E I+ ++ + + ++++L+ L
Sbjct: 2126 TIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG 2185
Query: 2046 QR------------------DEELRHQQEREQ------LLEKSLAQRVQENMIQEKQNLG 2081
+ +E LR + ++E + K+ + + E M + + G
Sbjct: 2186 HQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG 2245
Query: 2082 QEREEEEIRG-------------------LHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
+ + E RG ++EL+ +A+K Q I +L++ +
Sbjct: 2246 KRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVK---- 2301
Query: 2123 EALPHSHKTSPME---EQSLKL-------DSLEPRLQRELERLQAALRQ--TEAREIEWR 2170
EA K + EQ +K+ E L+REL+ L+ A Q E E+ +
Sbjct: 2302 EATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
Query: 2171 EKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
+A T L+E L+ + D E+Q L++E++ ++ LE
Sbjct: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE 2414
Score = 224 bits (571), Expect = 8e-58
Identities = 483/2509 (19%), Positives = 1018/2509 (40%), Gaps = 405/2509 (16%)
Query: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELM 324
+E++++ + EL D + + + ++ ++E E +I R T +++
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMK----- 62
Query: 325 EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384
AQE +L+L++V K + E + EN LE+ D +
Sbjct: 63 ---------AQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
Query: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444
+ + L ++ + ++D+ ++L ++ L ++++ E E LR+ ++L +
Sbjct: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
Query: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL---QGD 501
+ L +D Q ++DS ++E L R E L ++ + L + E+Q +
Sbjct: 174 EQLCQDIIDYQKQIDS---QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE 230
Query: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE----GE 557
+ Q +E ++ L +V+E E++ + ++A ++ + + L++ + L+ +
Sbjct: 231 KIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTD 290
Query: 558 LLRQEQTE----VTAALARAEQSIAELSSSENTL------------KTEVADLRAAAVKL 601
LL+ + E + A A+ E+ LSS ++ + K + A L A +
Sbjct: 291 LLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNV 350
Query: 602 SALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN 661
AL + + + Q+E+ + + E +N LQ + + ++ +
Sbjct: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
Query: 662 THLEAQLQKAEEAG--AEL-QADLRDIQEEKEEIQKKLSE-----------------SRH 701
+ L+ +K +EA AEL +AD R+ +E E K+L + ++
Sbjct: 411 STLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKN 470
Query: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE---------------VRLQ 746
Q + ++E L +E + E ++ + E EAL RE+ LE ++ Q
Sbjct: 471 QIKIRDREIEILTKEINKLELKISDFLDENEAL-RERVGLEPKTMIDLTEFRNSKHLKQQ 529
Query: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI---QTVTQAKEV 803
+ Q L ++++ L + L+ + + Q+ T G + + ++Q +
Sbjct: 530 QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRI 589
Query: 804 IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWE 863
+ ++ L L+ S+A+ + + +R+L + E++ LE+ + K N+L+E E
Sbjct: 590 SERKLDLLSLK---NMSEAQSKNEFLSRELIEKERD----LERSRTVIAKFQNKLKELVE 642
Query: 864 KERSWHQ--QELAKALESLEREKM----ELEMRLKEQQTEMEAIQAQREEERTQAESALC 917
+ + + +E+ +A++ ++++ E + + + + AI+++ E A L
Sbjct: 643 ENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK 702
Query: 918 QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ----- 972
+ L + L +++KE + SQQL + ++K+ L E+ET+ + Q++
Sbjct: 703 AQVDQLTGRNEELRQELRESRKEAINYSQQLAKA--NLKIDHL-EKETSLLRQSEGSNVV 759
Query: 973 ----------------------------LQEAQ------RELKEAARQHRDDLAALQEES 998
LQE + + L+++ + A ++ +
Sbjct: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
Query: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
S L ++ + + E K++ + +R +E +VQ+ + +EYN + L+ + +
Sbjct: 820 SLLYKEYLS---EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMK 876
Query: 1059 LSLMEKEQRLLVLQ--EADSIRQ-QELSALRQDMQEAQGEQKE--LSAQMELLR-----Q 1108
L E +++ VLQ E IRQ L L + +++ +QK LS + E+ Q
Sbjct: 877 KILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQ 936
Query: 1109 EVKEKEADFLA------QEAQLLEELEASHITEQQLRA-----------------SLWAQ 1145
KE +A + L ELE ++ +L A +L
Sbjct: 937 RFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHL 996
Query: 1146 EAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSG 1205
E + L+ ++ S +LE + QA Q S++ +A S+ S
Sbjct: 997 ECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS 1056
Query: 1206 GGDSAPSVWGLEPDQNGARSLFKRGPLLTAL--------SAEAVASALHKLHQDLWKTQQ 1257
+ + L Q L T+L E + L K++ D K +Q
Sbjct: 1057 KKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQ 1116
Query: 1258 -TRDVLRDQVQKL-----EERLTDTEAEKSQVHTELQDL-------QRQLSQNQEEKSKW 1304
RD L D V K +R+ + E + ++ E+ L +RQ+ ++
Sbjct: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSR 1176
Query: 1305 EGKQNSLESELME-------------LHETMASLQSRLRRA---------ELQRMEAQGE 1342
+ + SL +L++ LH+ SLQ A +LQ+MEA
Sbjct: 1177 DKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNL 1236
Query: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
R + L A+ + +HL+ + R Q S A L + + +++ ++L+N+
Sbjct: 1237 RLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQND 1296
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
+++ +E + QE + + K L+ L L + L E ++ +G + + ++
Sbjct: 1297 KLKIMQEMKNSQQEHRNM---ENKTLEMELKL--KGLEELISTLKDTKGAQKVINWHMKI 1351
Query: 1454 QKAALELLSL--DLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI- 1510
++ L+ L L +L K +E+ I E E+ S LE + ++ K +R+
Sbjct: 1352 EELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV----QQNKFHEERQMAW 1407
Query: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELEENHHKM 1569
+ E D E Q ++ + Q E+ Q E G + D L LE +++EN +
Sbjct: 1408 DQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
Query: 1570 ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD 1629
+ K LE + + + AL ++ R + + ++ ++A EL ++
Sbjct: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIA-ELGRKE 1526
Query: 1630 QEVKS-------------------QREQIEE-----LQRQKEHLTQDLERRDQELMLQKE 1665
E KS Q+E++ + L++ +E + +++ +++L +
Sbjct: 1527 MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHH 1586
Query: 1666 RIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725
R+++ D + K DL + + + ++ Q AE+ S L
Sbjct: 1587 RLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSL----LV 1642
Query: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQL----EQQLQGLHRKVGETSLLLSQREQEIV 1781
+K + +D E++ E + + E + +K QL E +++ + +V + LL Q ++E
Sbjct: 1643 KLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQ 1702
Query: 1782 VLQQQLQEARE-QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
L+ +LQ +E ++++ ++ + LA ++++ +AL + + + + E+
Sbjct: 1703 CLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEER 1762
Query: 1841 DALQGALEQAHMTLK---ERH-----GELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
+ ++AH+ ++ +RH +++D E +L+E L R +L + L DL
Sbjct: 1763 IISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDL 1822
Query: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQ--DSWLQAQAVLKERDQELEALRAESQ 1950
E ++++KA + ++ E QE++ R ++ S LQ + + + +E L+ + +
Sbjct: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
Query: 1951 SSRHQEEA------------ARARAEALQEALGKAHAA--------LQGKEQHLL----- 1985
+Q E A+ E ++ GK A L+ KE +
Sbjct: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
Query: 1986 -------------EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
E+ L R L+ + T+ L S + E L+ + ++++ D+
Sbjct: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEN-DIL 2001
Query: 2033 YQEDVQQLQQALAQRDEEL--RHQQEREQLLEKSLAQ---------------RVQENMIQ 2075
Y Q L + D L R+ QE+ LEK ++ Q
Sbjct: 2002 YMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQEL 2061
Query: 2076 EKQNLGQEREEEEIR-GLHQSVRELQLTLAQKEQEILELRETQQRNNLEA---LPH---- 2127
+K+NL E E++ L Q+ ++L L + +++ E+ E ++ E L H
Sbjct: 2062 QKENLKLSSENIELKFQLEQANKDLP-RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGS 2120
Query: 2128 --SHKTSPMEEQSLKL-DSLEPRLQRELERLQAA---LRQTEAREIEWREKAQDLALSLA 2181
S KT P E+++ L + ++QRE E+L+ A L + IE ++ + L L
Sbjct: 2121 GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIE--QENEKLKAELE 2178
Query: 2182 QTKASVSSLQEVAMFLQASVLERD---SEQQRLQDELELTRRALEKER-----LHSPGAT 2233
+ KA + +++M ++ + +E +RL+ EL+ A EK R L
Sbjct: 2179 KLKAHLG--HQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEK 2236
Query: 2234 STAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWR-----------------------Q 2270
T +L G++ +Q E G P +G + +SW+ Q
Sbjct: 2237 MTVQLEETGKR-LQFAESRG----PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQ 2291
Query: 2271 RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE------RERRKLKREAMRAAQAGSLE 2324
+ L+Q V ++ ++N L ++ ++ + LKRE ++ + + +
Sbjct: 2292 SITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE-LQVLRLANHQ 2350
Query: 2325 ISKATASSPTQQDGRGQKNSDAKCVA---ELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381
+ K A Q + ++ + +L++++ L+ QL + +KQ +
Sbjct: 2351 LDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410
Query: 2382 RELAGLHHSLSHSLLAV-----AQAPEATVLEAETRRLDESLTQSLTSP 2425
+EL S + + + + +LE + ++L E L LTSP
Sbjct: 2411 KELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSP 2459
Score = 120 bits (302), Expect = 1e-26
Identities = 286/1411 (20%), Positives = 596/1411 (42%), Gaps = 224/1411 (15%)
Query: 23 QVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGG 82
++L QQQ + + S R +AQ + +L+ KL Q+ Q E
Sbjct: 1167 EILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLH----QHNVSLQLSEATALGKLE 1222
Query: 83 PIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA--LREDVEK 140
I + + +E NL L +L+E++Q L+ + + N+A LR+ ++
Sbjct: 1223 SITSKLQKMEAYNL-RLEQKLDEKEQA------------LYYARLEGRNRAKHLRQTIQS 1269
Query: 141 LTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDR 200
L +S A +++F K ++ ++ +L + +E+ ++ M++ T
Sbjct: 1270 LRRQFSGALP--------LAQQEKFSKTMIQLQNDKL-KIMQEMKNSQQEHRNMENKTLE 1320
Query: 201 DLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEA 260
MELK + + L L+ T GAQ +++ K +EL +
Sbjct: 1321 --MELKLKGLEE----LISTLKDTKGAQ----------------KVINWHMKIEELRLQE 1358
Query: 261 HERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNH 320
+ ++EL++ K + + + +S+L + +QN+ +E+ A + LE
Sbjct: 1359 LKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLE-RQ 1417
Query: 321 TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENS---LELDSSIFS 377
++ + + + NA ++ I D + + + + IA EN LE ++ S
Sbjct: 1418 LDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLE-IALRKIKENIRIILETRATCKS 1476
Query: 378 -QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQR 436
+ ++ + AL L + R + + +LR +L E L+ + + E E K+
Sbjct: 1477 LEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRK-EMEPKSHHT- 1534
Query: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
L T+A L + + L K + LL+KAREE Q E++++ L ++ L
Sbjct: 1535 ---LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREE---QREIVKKHEEDLHILHHRL 1588
Query: 497 QLQGDSAQGQKEEQQEELHL-------AVRERERLQEMLMGLEAKQSESLSEL------- 542
+LQ DS+ + ++ +L + RL EM + A+Q +SLS L
Sbjct: 1589 ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTV-AEQDDSLSSLLVKLKKV 1647
Query: 543 ---------ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
IT + E +++ +L + EV A E L S+ + ++
Sbjct: 1648 SQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSE 1707
Query: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR 653
L+A S + V + L L+E+ Q SR +A ++ A E+
Sbjct: 1708 LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA----EMTAAAEERI 1763
Query: 654 REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
A +K HL Q Q + EL+ + D+ E ++++ L S++++ + T L L
Sbjct: 1764 ISATSQKEAHLNVQ-QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDL 1822
Query: 714 HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER---------DRQDLAEQLQ-GLS 763
+ E +++++ + ++EKE + +E L+ +++ + ++Q L E+LQ +
Sbjct: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
Query: 764 SAKELLESSLFEA-----QQQNSVIEVTKGQ----LEVQIQTVTQAKEVIQGEVRCLKLE 814
+ LE + E +++N+ E+ + + + +I+ + + +GEV L +
Sbjct: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
Query: 815 LDTER---SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ 871
L+T + ++A++E+ R+L L + EKE+ +L K+R+ +
Sbjct: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEEL-----KKRNLDLE 1997
Query: 872 E---LAKALESLEREKMELEMRLKEQ--QTEMEAIQAQREEERTQAESAL-------CQM 919
+A ++L R+ + ++ L+ + Q ++ A++ Q ++ S CQ
Sbjct: 1998 NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQR 2057
Query: 920 QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE----------------- 962
+ E +KE + L ++ + +L A++ L RL+ +V+ LKE
Sbjct: 2058 EQELQKENLKLSSENIELKFQLEQANKDLPRLKN--QVRDLKEMCEFLKKEKAEVQRKLG 2115
Query: 963 ---------------QETTGILQTQLQEAQRE---LKEAARQHRDDLAALQEESSSLLQD 1004
++T G+++ +++ QRE LK+A+ E+ +++ Q+
Sbjct: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASG------ILTSEKMANIEQE 2169
Query: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
L+ ++E LK+ L Q + + EK+ E R++KEL++E L
Sbjct: 2170 NEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI--IAENERLRKELKKE-TDAAEKLRIA 2226
Query: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS--------AQMELLRQEVKEKEAD 1116
+ L +L E +++ +E + R E++G Q E + + ++KE E D
Sbjct: 2227 KNNLEILNEKMTVQLEE-TGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETD 2285
Query: 1117 FLAQEAQLLEELE--ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
+A++ Q + +L+ TE++ + + + ++ + Q+++ E AE + G
Sbjct: 2286 -IAKKNQSITDLKQLVKEATEREQKVNKYNEDLE-QQIKILKHVPE------GAETEQGL 2337
Query: 1175 QAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLT 1234
+ + Q L+ A + + + EL ++ DQ+GA S T
Sbjct: 2338 KRELQ--------VLRLANHQLDKEKAELIHQIEA-------NKDQSGAES--------T 2374
Query: 1235 ALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
A+ + + L L + + L+++++KL++ L + + E++DL+
Sbjct: 2375 IPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFD---PSFFEEIEDLKYNY 2431
Query: 1295 SQNQEEKSKWEGKQNSLESEL-MELHETMAS 1324
+ ++ E K L +L +EL +A+
Sbjct: 2432 KEEVKKNILLEEKVKKLSEQLGVELTSPVAA 2462
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 219 bits (559), Expect = 2e-56
Identities = 359/1691 (21%), Positives = 745/1691 (44%), Gaps = 257/1691 (15%)
Query: 277 EKAELQDRVTELSALLTQSQKQ---NEDYEKMIKALRETVEILETNHTELME---HEASL 330
E + L+ V + S+ Q N D ++ K L+ ++ L+ N ++ ++ HE S+
Sbjct: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICK-LQNIIKELKQNRSQEIDDHQHEMSV 238
Query: 331 SRNAQEEKLS-----LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDAD 385
+NA ++KL+ ++ + D + +EE +N+ Q G S +++ + ++ Q
Sbjct: 239 LQNAHQQKLTEISRRHREELSDYEE-RIEELENLLQQGG---SGVIETDLSKIYEMQKTI 294
Query: 386 KALTLVRSVLTRRRQ----AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
+ L + + T++ + ++D+ ++L+ + ++L+++ +Q E + + + + L
Sbjct: 295 QVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLK 354
Query: 442 GERDTLAGQTVDLQGEVDSLS-KERELLQKAREE----LRQQLEVLEQEAWRLRRVNVEL 496
E L V + D+++ KER L Q A E L+Q L E E RL +N +
Sbjct: 355 LECSKLQPSAVK---QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDN 411
Query: 497 QLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL 554
L D+ + + E ++E L +E+E LQ L+ L + E + T +L+S
Sbjct: 412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN-NEYEVIKSTATRDISLDSELH 470
Query: 555 EGEL-LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS-------ALNE 606
+ L L ++ E+ +++ E IAE+ + + + +LS ++
Sbjct: 471 DLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIIS 530
Query: 607 ALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEA 666
L D +++ QLE++ + ++ ++ +V L + ++ L +K +L
Sbjct: 531 KLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVD 590
Query: 667 QLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR 726
QL K++E+ +Q + +++E + +++LS R++ ++ L+Q++
Sbjct: 591 QLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNE------LMQSLNQDSNS------- 637
Query: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786
K+ L++E+ A EVR +L + L L E L+ F+ + +N + +
Sbjct: 638 --NFKDTLLKEREA-EVR---------NLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
Query: 787 KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
+ Q++ + E + L E+ + E E A ++L + + + +E+
Sbjct: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE 745
Query: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT---EMEAIQA 903
A + L+ + E L K + + E EL+ +++ T E + + +
Sbjct: 746 LSNARNLNTSALQLEHE--------HLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLS 797
Query: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL---ERLRQ-----DM 955
EE+ Q + + ++ EK L E + Q+EL SQ L E LRQ D
Sbjct: 798 SSLEEQKQLTQLINKKEIFIEK----LKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 956 KVQKLKEQETTGILQTQLQEAQRELKEAA----RQHRDDLAALQEESSSLLQDKMDLQKQ 1011
+ +KE+ LQ +L+ + E A + D + L E S L K L+++
Sbjct: 854 SLGSMKEENNH--LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 911
Query: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
++ + + Q+ S+ + Q +QE+ +E E+ + + E+ A+ T +EK++ + L
Sbjct: 912 IKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEF---RYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 1072 QEADSIRQQELSALRQDMQ-----------------EAQGEQKELS-AQMELLRQEVKEK 1113
Q+ + +L RQD+Q E E+ +LS A+ E L + +KE+
Sbjct: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKER 1028
Query: 1114 EADFLAQEAQLLEELEASHITEQ----------QLRASLWAQEAKAAQLQLRLRST---- 1159
E E +LL E S +T+Q +L + ++ + L R+ ST
Sbjct: 1029 EL-----EIKLLNEKNIS-LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQ 1082
Query: 1160 -----ESQLEALAAEQQP-----GNQAQAQAQLASLY-------SALQQALGSVCESRPE 1202
+ QL+A A E++ + + + L + Y +A + AL + + +
Sbjct: 1083 DVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
Query: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRG-----------PLLTALSAEAVASALHKLHQD 1251
LS +S+ E QN +R + ++ LL L + + ++ +
Sbjct: 1143 LSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN 1202
Query: 1252 LW-KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK--- 1307
+ + Q RD L+ QV+K+EE K QV T +Q++Q + +Q QEE + + +
Sbjct: 1203 QFEELLQERDKLKQQVKKMEE-------WKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
Query: 1308 ----QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
+ L+ + L ++ +++L+ + + Q L K+ L +++ +
Sbjct: 1256 DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS-- 1313
Query: 1364 VVEARAQASAAGIL----EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419
Q S+A +L E LR ++S ++ +E E ++ + L++ + K A + L
Sbjct: 1314 -----PQLSSASLLTPQSAECLRASKS--EVLSESSELLQQELEELRKSLQEKDATIRTL 1366
Query: 1420 QENLALLTQTLAEREE----EVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
QEN L+ ++A E E E +I++L++++++ + L+ L +K ++ ++
Sbjct: 1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSS 1426
Query: 1476 QE----QIQELEKCRSVLEHLPMAVQEREQ---KLTVQREQIRELEKDRETQRNVLEHQL 1528
E ++ E E R + +L + E KL + E+I E + +ET+ L+
Sbjct: 1427 NENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETN 1486
Query: 1529 LELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV 1588
+ K M+ + + +K++ + E +L+KE E + +
Sbjct: 1487 M---KFSMMLREKEFECHSMKEKALAFE-----------------QLLKEKEQGKTGELN 1526
Query: 1589 ALTHLTLDLEERSQELQAQSSQI----HDLESHSTVLARELQE-RDQEVKSQREQIEELQ 1643
L + ++E++ Q + Q+ + +T L E+Q RD+E +S +EL+
Sbjct: 1527 QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN----QELE 1582
Query: 1644 RQKEHLTQD--------LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL---SL 1692
R + HL + L D+E L+K ++ VLE++ + +E Q + SL
Sbjct: 1583 RLRNHLLESEDSYTREALAAEDREAKLRK-KVTVLEEKLVSSSNAMENASHQASVQVESL 1641
Query: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL---RDKEK-----EVECQQEH 1744
+E+ ++ QR + + K SL +++++L + +EK E+E Q++
Sbjct: 1642 QEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQL 1701
Query: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLL---SQREQEIVVLQQQLQEAREQGELKEQSL 1801
I E ++ + LE ++ L + E + L S+ +++ V ++Q++E + Q EL+
Sbjct: 1702 IAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELR---- 1757
Query: 1802 QSQLDEAQRAL 1812
Q LD+ Q+ L
Sbjct: 1758 QEMLDDVQKKL 1768
Score = 216 bits (550), Expect = 2e-55
Identities = 388/1900 (20%), Positives = 803/1900 (42%), Gaps = 287/1900 (15%)
Query: 437 LQKLTGE-----RDTLAGQTVDLQGEV-DSLSKERE----LLQKAREELRQQLEVLEQEA 486
L LTG+ +D L T +++ E+ DS +KE E +L+ E L++ LE++
Sbjct: 23 LASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKH 82
Query: 487 WRLRRVNVELQLQGDSAQGQKEEQQEEL-HLAVRERERLQEMLMGLEAKQSESLSELITL 545
++++ Q S + Q ++++ E+ HL R+ LQ+ L+ L++ S
Sbjct: 83 ---EASEIQIKQQSTSYRNQLQQKEVEISHLKARQIA-LQDQLLKLQSAAQSVPSGAGVP 138
Query: 546 REALESSHLEG-----ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLR--AAA 598
SS G + + ++ ++Q I LS+ + L++EV R A
Sbjct: 139 ATTASSSFAYGISHHPSAFHDDDMDFGDIIS-SQQEINRLSNEVSRLESEVGHWRHIAQT 197
Query: 599 VKLSALNEALALDKVGLNQQLLQLEEE-NQSVCSRMEAAEQARNALQVDLAEAEKR-REA 656
K + + + L + +L++ +Q + +NA Q L E +R RE
Sbjct: 198 SKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREE 257
Query: 657 LWEKNTHLEAQLQKAEEAGAE-LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
L + +E ++ G+ ++ DL I E +QK + + ++ +T ++EQL
Sbjct: 258 LSDYEERIEELENLLQQGGSGVIETDLSKIYE----MQKTIQVLQIEKVESTKKMEQLED 313
Query: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
+ K + L+ A +++ L RE+ L V +++ + E+ + L L+ S +
Sbjct: 314 KIKDINKKLSSAENDRDILRREQEQLNV-------EKRQIMEECENLKLECSKLQPSAVK 366
Query: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ 835
Q T+T+ + ++ + +E QA + + +L+
Sbjct: 367 -----------------QSDTMTEKERIL---AQSASVEEVFRLQQALSDAENEIMRLSS 406
Query: 836 AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895
Q+ A + K EV EKE+S L +EK EL+M L +
Sbjct: 407 LNQDNSLAEDNLKLKMRIEV------LEKEKSL-----------LSQEKEELQMSLLKLN 449
Query: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
E E I++ + +S L ++L E + L +++ + + +A+ ++L+R Q+
Sbjct: 450 NEYEVIKSTATRD-ISLDSELHDLRLNLEAKEQELNQSISEKETLIAEI-EELDRQNQEA 507
Query: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
+ +++ QL + Q E + + DL ++ L DKMD+ K+++
Sbjct: 508 TKHMI-------LIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
Query: 1016 KSQLVAQD---DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
K +L+ + + L +Q++++K+ N + + + +++++++ +KE L L+
Sbjct: 561 KEKLIQSEVALNDLHLTKQKLEDKVE-----NLVDQLNKSQESNVSI---QKEN--LELK 610
Query: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASH 1132
E ++ELS +R ++ ++ + + + LL++ +E E L Q LE+L
Sbjct: 611 EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE--REAEVRNLKQNLSELEQLN--- 665
Query: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
+ L+ + + + +L L QLE A GN Q + ++ L+
Sbjct: 666 ---ENLKKVAFDVKMENEKLVLACEDVRHQLEECLA----GNN-QLSLEKNTIVETLKME 717
Query: 1193 LGSV----CESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL 1248
G + C ++ L + A + + AR+L SAL
Sbjct: 718 KGEIEAELCWAKKRLL---EEANKYEKTIEELSNARNLN--------------TSALQLE 760
Query: 1249 HQDLWKTQQTRDVLRDQVQK-LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
H+ L K Q +D+ +++K +E+ TD + K + + L++ Q+QL+Q +K + K
Sbjct: 761 HEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE-QKQLTQLINKKEIFIEK 819
Query: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE---NLTAQVEHLQA-- 1362
L+ +L E + LR+ E+ R + + L + KE +L ++E L+
Sbjct: 820 ---LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
Query: 1363 -------------AVVEARAQASAAGILEEDLRTA-RSALKLKNEEVESERERAQALQEQ 1408
+V E ++ S ++E L + K+ ++ +S+ + Q+LQEQ
Sbjct: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ 936
Query: 1409 GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKR 1468
+ ++ A TQ E++EE+++L+ I++++ Q ++ ++ + D+ +
Sbjct: 937 KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE 996
Query: 1469 NQEVDLQQEQIQEL-EKCRSVLEHLPMAVQEREQKLTVQRE-------QIRELEKDRETQ 1520
+ L E E + ++ E L ++ERE ++ + E QI +L KD
Sbjct: 997 TKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD---- 1052
Query: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV----TLECLALELEENHHKMECQQKLI 1576
E+ K Q+I+ + ++Q L ++ T + + L+ + + ME ++
Sbjct: 1053 ---------EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFA 1103
Query: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
E RE +HL + + + A+ + + L+ + L+ + Q++ R
Sbjct: 1104 VLNEKTREN-----SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMF--R 1156
Query: 1637 EQIEELQR---QKEHLTQDLERRDQELML-----------------QKERIQVLEDQRTR 1676
E I+ L R +K+ L ++ Q L+ Q E + D+ +
Sbjct: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216
Query: 1677 QTKILEEDLEQIKLSLRERGRELTT-QRQLMQERAE---EGKGPSKAQRG------SLEH 1726
Q K +EE +Q+ +++ E Q +L Q +A+ + SK Q S E
Sbjct: 1217 QVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQ 1276
Query: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ-------E 1779
+ L++ +E+ Q I +L KD L +L + ++ SLL Q + E
Sbjct: 1277 NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE 1336
Query: 1780 IV-----VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
++ +LQQ+L+E R+ + K+ ++++ + R E ++E +Q + +
Sbjct: 1337 VLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK 1396
Query: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKE-------QARRLEEELAVEGRRVQALEE 1887
++KEK D LQ L++ + +K + +L E + L + + R+ LE
Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456
Query: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947
+G L+ E+ ++ E + E E +ALQ++ ++ +L+E++ E +++
Sbjct: 1457 DIGKLKGEN-----------EKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMK- 1504
Query: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007
E A A + L+E QGK L + +S++ T Q D
Sbjct: 1505 ---------EKALAFEQLLKE-------KEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ 1548
Query: 2008 CQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ----QEREQL 2060
+Q + AL+ + ++D++ R +++++L+ L + ++ + ++RE
Sbjct: 1549 VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAK 1608
Query: 2061 LEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN 2120
L K + V E + N + + + +L + Q+++ L+L +Q++
Sbjct: 1609 LRKKVT--VLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQV 1666
Query: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDL---A 2177
AL ++ +E Q E A L + + EW++ A++L
Sbjct: 1667 KQYALSLANLQMVLEHFQ----------QEEKAMYSAELEKQKQLIAEWKKNAENLEGKV 1716
Query: 2178 LSLAQTKASVSSLQEVAMFL--QASVLERDSEQQRLQDEL 2215
+SL + ++ + A L Q V E E+ + Q+EL
Sbjct: 1717 ISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNEL 1756
Score = 200 bits (509), Expect = 1e-50
Identities = 361/1732 (20%), Positives = 726/1732 (41%), Gaps = 298/1732 (17%)
Query: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE 860
K+++ ++ EL R++ + A R + ++ T LE++ A E ++ Q
Sbjct: 35 KDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQST 94
Query: 861 KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALC--- 917
+ + + E++ L+ ++ L+ +L + Q+ +++ + T A S+
Sbjct: 95 SYRNQLQQKEVEISH----LKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGI 150
Query: 918 --------------------QMQLETEKERVSLLET-------LLQTQK-ELADASQQLE 949
Q ++ VS LE+ + QT K + D S Q E
Sbjct: 151 SHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSE 210
Query: 950 RLRQDMKVQKLKEQETTGILQTQ-----LQEA-QRELKEAARQHRDDLAALQE---ESSS 1000
+ +++LK+ + I Q LQ A Q++L E +R+HR++L+ +E E +
Sbjct: 211 ICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELEN 270
Query: 1001 LLQD------KMDLQKQVEDLKSQLVAQ---DDSQRLVEQ------EVQEKL-------- 1037
LLQ + DL K E K+ V Q +S + +EQ ++ +KL
Sbjct: 271 LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
Query: 1038 ---RETQEYNRIQKELEREKASLTL-------------SLMEKEQRLLVLQEADSIRQQE 1081
RE ++ N ++++ E +L L M +++R+L A S +E
Sbjct: 331 ILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERIL----AQSASVEE 386
Query: 1082 LSALRQDMQEAQGEQKELSAQME-----------LLRQEVKEKEADFLAQEAQLLEELEA 1130
+ L+Q + +A+ E LS+ + +R EV EKE L+QE EEL+
Sbjct: 387 VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEK---EELQM 443
Query: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQAQAQLASLYSA 1188
S + + + + L L LEA E Q + A++ L
Sbjct: 444 SLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQ 503
Query: 1189 LQQALGSVCESRPELSGGGDSAPSVWG-LEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Q+A + + +LS + S+ L+ D N + +H+
Sbjct: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK------------------KRVHQ 545
Query: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
L D + DV ++++ + E L D K ++ ++++L QL+++QE
Sbjct: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV----- 600
Query: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL-TAQVEHLQAAVVE 1366
S++ E +EL E + R EL R+ + + L Q + N ++ +A V
Sbjct: 601 --SIQKENLELKEHI-----RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
Query: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
+ S L E+L+ +K++NE++ E + L+E LA
Sbjct: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR-------------HQLEECLAGN 700
Query: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Q E+ VETL+ + E+E + L K+ +E + ++ I+EL R
Sbjct: 701 NQLSLEKNTIVETLKMEKGEIEAE----------LCWAKKRLLEEANKYEKTIEELSNAR 750
Query: 1487 SV--------LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
++ EHL Q+++ ++ ++ I +++ D + ++VL L E ++ Q+I
Sbjct: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
Query: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598
+ ++ LK++ L+ + + K E ++ I+E + + + HL +L
Sbjct: 811 NKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL- 869
Query: 1599 ERSQELQAQSSQIHDLESHSTV--LAREL-------QERDQEVKSQREQIEELQRQKEHL 1649
ER +E Q++++ + D ++ +V LA E+ + ++E+K ++ IE+ + K L
Sbjct: 870 ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL 929
Query: 1650 TQDLERRDQEL---MLQKERIQVLEDQ----RTRQTKILEEDLEQIKLSLRERGRELTTQ 1702
Q L+ + +E+ Q E++ Q + + K L++ +EQIK L E +++ T
Sbjct: 930 LQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTD 989
Query: 1703 R-QLMQERAEEG----KGPSKAQRGSLEHMKLILRDKEKEVECQ---------------- 1741
+ QE + G K E +L+ KE+E+E +
Sbjct: 990 NSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL 1049
Query: 1742 -QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE----- 1795
++ + +L ++ Q + ++Q LH ++ TS Q++V LQQQLQ + E
Sbjct: 1050 SKDEVGKLTQIIQQKDLEIQALHARISSTS-----HTQDVVYLQQQLQAYAMEREKVFAV 1104
Query: 1796 LKEQS-----LQSQLDEAQRALAQRDQELEALQQEQQ------QAQGQE---------ER 1835
L E++ L+++ + +A ++ L LQ E + ++ GQ+ R
Sbjct: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
Query: 1836 VKEKADALQGALEQAHMTL----------KERHGELQDHKEQARRLEEELAVEGRRV--- 1882
+ + D AL Q TL E G + E+ + ++L + +++
Sbjct: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224
Query: 1883 -QALEEVLGDLRAESREQEKALLALQQQC---AEQAQEHEVETRALQDSWLQAQAVLKER 1938
Q + + +++ ES + ++ L LQ Q ++ + +V+ L S+ Q + LK
Sbjct: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF 1284
Query: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALG--------KAHAALQGKEQHLLEQAE- 1989
QEL ++ + ++ + + + L A K + L E +E
Sbjct: 1285 GQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344
Query: 1990 LSRSLEASTATLQ---ASLDACQAHSRQLEEA------LRIQEGEIQDQDLRYQEDVQQL 2040
L + LE +LQ A++ Q ++ +L ++ L +E E D +++ ++ Q +
Sbjct: 1345 LQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDV 1404
Query: 2041 QQALAQRDEELRHQQEREQLL--EKSLAQRVQENMI--QEKQNLGQ-----EREEEEIRG 2091
Q L ++++L + + +QLL ++ +V EN + Q NL + E + +++G
Sbjct: 1405 LQKLL-KEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG 1463
Query: 2092 LHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL----EPR 2147
++ + E T KE E L+ET + ++ + M+E++L + L E
Sbjct: 1464 ENEKIVE---TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
Query: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
EL +L A++ + + + ++++ + L+L Q + ++LQ L+ + E
Sbjct: 1521 KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580
Query: 2208 QQRLQDEL-----ELTRRALEKE----RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258
+RL++ L TR AL E +L +L S + V+ E
Sbjct: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVES 1640
Query: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
+ + S ++ LQ +V++ ++ + L N+Q+ LE ++E + +
Sbjct: 1641 LQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM--VLEHFQQEEKAM 1690
Score = 194 bits (492), Expect = 1e-48
Identities = 352/1706 (20%), Positives = 702/1706 (41%), Gaps = 291/1706 (17%)
Query: 227 AQSREPNGSGRMDGREPAQLLLLLA-----KTQELEKEAHERS-------QELIQLKSQG 274
AQ+ + G+ D E +L ++ ++QE++ HE S Q+L ++ +
Sbjct: 195 AQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRH 254
Query: 275 DLEKAELQDRVTELSALLTQ--SQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSR 332
E ++ ++R+ EL LL Q S D K+ + +++T+++L+ E + L
Sbjct: 255 REELSDYEERIEELENLLQQGGSGVIETDLSKIYE-MQKTIQVLQIEKVESTKKMEQLED 313
Query: 333 NAQE--EKLSLQQVIKDITQVMVEEGDNIAQGSGHEN--SLELDSSIFSQFDYQDADKAL 388
++ +KLS + +DI + +E N+ + E +L+L+ S + +D
Sbjct: 314 KIKDINKKLSSAENDRDILR-REQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSD--- 369
Query: 389 TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLA 448
+T + + + Q A +E L Q D E RL L + ++LA
Sbjct: 370 -----TMTEKERILA----QSASVEEVFRLQQALSDAENEI-----MRLSSLNQD-NSLA 414
Query: 449 GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV---NVELQLQGDSAQG 505
+ L+ ++ L KE+ LL + +EEL+ L L E ++ ++ L + +
Sbjct: 415 EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRL 474
Query: 506 QKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGEL------- 558
E +++EL+ ++ E+E L + L+ + E+ +I +++ L EG+
Sbjct: 475 NLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ 534
Query: 559 -----------LRQEQTEVTAAL-------ARAEQSIAELSSSENTLKTEVADLRAAAVK 600
L ++ ++T L ++E ++ +L ++ L+ +V +L K
Sbjct: 535 DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNK 594
Query: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSR-MEAAEQARNALQVDLAEAEKRREALWE 659
N ++ + + L + + Q EEE + + M++ Q N+ D E+ E
Sbjct: 595 SQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEV--- 651
Query: 660 KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK- 718
+L+ L + E+ L+ D++ E E++ + RHQ E QL E
Sbjct: 652 --RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT 709
Query: 719 -------RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ------------------ 753
+ E+ A K+ L+ E E ++ + R
Sbjct: 710 IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQ 769
Query: 754 ----DLAEQLQGLSS-------AKELLESSLFEAQQQNSVIEVTK----------GQLEV 792
++AE + + K++L SSL E +Q +I + +L+
Sbjct: 770 KKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQE 829
Query: 793 QIQTVTQA-------KEVIQGEVRCL---KLELDTERSQAEQERDAAARQLAQAEQEGKT 842
++ +QA ++ I+ + R L K E + + + E+ R+ +R A+ +
Sbjct: 830 ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
Query: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
++ + A+ ++N ++E E+E HQ K +E + KM+L L+EQ+ EM+ +
Sbjct: 890 SVTEL-ASEVSQLNTIKEHLEEEIKHHQ----KIIEDQNQSKMQLLQSLQEQKKEMDEFR 944
Query: 903 AQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER----LRQDMKVQ 958
Q E Q + Q+ LE ++E SL +T+ Q + +L + Q ++ + Q+ KVQ
Sbjct: 945 YQHE----QMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQ 1000
Query: 959 KLKEQETTGILQTQLQEAQRE-LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
L + G + L +A+ E L + ++ ++ L E++ SL + L K +
Sbjct: 1001 SLNIE--NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT 1058
Query: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL-----EREKASLTLSLMEKEQRLLVLQ 1072
Q++ Q D + TQ+ +Q++L EREK L+ +E L
Sbjct: 1059 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL--- 1115
Query: 1073 EADSIRQQELSALRQ-DMQEAQGEQKELSAQMELLRQEV--------------KEKEADF 1117
+ + + ++ A ++ + + Q E K+LS + E Q++ K+ E D
Sbjct: 1116 KTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDA 1175
Query: 1118 LAQEAQLL---------------------EEL--EASHITEQQLRASLWAQEAKAAQLQL 1154
L+Q+ Q L EEL E + +Q + W Q+ +
Sbjct: 1176 LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNM 1235
Query: 1155 RLRSTESQLEALAAEQQ----PGNQAQAQAQLASLYSA-----------------LQQAL 1193
+ S + Q E + Q N ++ Q L + +Q ++
Sbjct: 1236 QHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSI 1295
Query: 1194 GSVCESRPELSGGGDSAPSVWGLEPDQNGARSLF-KRGPLLTALSAEAVASALHKLHQ-- 1250
G +C ++ L G D + P + A L + L A +E ++ + L Q
Sbjct: 1296 GQLCNTKDLLLGKLDI------ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL 1349
Query: 1251 -DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
+L K+ Q +D +Q+ RL+D+ A S++ +++ Q E + + KQ+
Sbjct: 1350 EELRKSLQEKDATIRTLQENNHRLSDSIAATSELE------RKEHEQTDSEIKQLKEKQD 1403
Query: 1310 SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ-------- 1361
L+ L E + + +L + E ELL+ A NL ++ L+
Sbjct: 1404 VLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG 1463
Query: 1362 --AAVVEA-RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418
+VE R + + L+E L+ K E S +E+A A ++ + K QGK
Sbjct: 1464 ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK-EQGKT 1522
Query: 1419 LQENLAL-LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK----KRNQEVD 1473
+ N L +++ E+ + R Q+ KQ++M+ AL+ L+ + NQE++
Sbjct: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Query: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH------- 1526
+ + E E + +A ++RE KL R+++ LE+ + N +E+
Sbjct: 1583 RLRNHLLESEDSYT---REALAAEDREAKL---RKKVTVLEEKLVSSSNAMENASHQASV 1636
Query: 1527 QLLELEKKDQMIESQRGQV--------QDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578
Q+ L+++ ++ QR + + +K+ ++L L + LE H + E + E
Sbjct: 1637 QVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLE--HFQQEEKAMYSAE 1694
Query: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638
LE Q++ L + ++ ++ L+ + + + + +++ + EQ
Sbjct: 1695 LEKQKQ--------LIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
Query: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDL---------EQIK 1689
IEEL+RQ E + L+ +QK+ + + + K+L +L Q
Sbjct: 1747 IEELKRQNELRQEMLDD------VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH 1800
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKG 1715
LR G L +R+ M++ + +G
Sbjct: 1801 EVLRLMGSILGVRREEMEQLFHDDQG 1826
Score = 127 bits (320), Expect = 1e-28
Identities = 245/1232 (19%), Positives = 503/1232 (40%), Gaps = 183/1232 (14%)
Query: 1258 TRDVLRDQVQKLEERLTDTEAEKSQ-VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELM 1316
T+D+L + +++E L D+ ++ + +H L+ S+N+ K + E+ +
Sbjct: 34 TKDMLMEGTEEVEAELPDSRTKEIEAIHAILR------SENERLKKLCTDLEEKHEASEI 87
Query: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGI 1376
++ + S +++L++ E+ E L+A + L Q+ LQ+A A++ S AG+
Sbjct: 88 QIKQQSTSYRNQLQQKEV-------EISHLKARQIALQDQLLKLQSA---AQSVPSGAGV 137
Query: 1377 LEEDLRTARSALKLKNEEVES-----ERERAQALQEQGELKVAQGKALQENLALLTQTLA 1431
TA S+ S + + + Q E+ L ++ L +
Sbjct: 138 ---PATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN-----RLSNEVSRLESEVG 189
Query: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKK-RNQEVDLQQEQIQELEKCRSVLE 1490
+T + Q + Q E+ K L+ + +LK+ R+QE+D Q ++ L+
Sbjct: 190 HWRHIAQTSKAQGTDNSDQSEICK--LQNIIKELKQNRSQEIDDHQHEMSVLQNAH---- 243
Query: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
+QKLT + RE D E + LE+ L + +IE+ ++ +++K
Sbjct: 244 ---------QQKLTEISRRHREELSDYEERIEELENLLQQ--GGSGVIETDLSKIYEMQK 292
Query: 1551 QLVTLECLALELEENHHKMECQQKLIKEL-------EGQRETQRVALTHLTLDLEERSQE 1603
T++ L +E E+ KME + IK++ E R+ R L ++ + +E
Sbjct: 293 ---TIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEE 349
Query: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
+ + L+ + + + E+++ + +Q +EE+ R L Q L + E+M
Sbjct: 350 CENLKLECSKLQPSAVKQSDTMTEKER-ILAQSASVEEVFR----LQQALSDAENEIM-- 402
Query: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
R+ L Q L ED L L+ R L ++ L+ + EE +
Sbjct: 403 --RLSSLN-----QDNSLAED----NLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
Query: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
E +K +++ E L +L+ LE + Q L++ + E L+++ E+ L
Sbjct: 452 YEVIK---STATRDISLDSE----LHDLRLNLEAKEQELNQSISEKETLIAEIEE----L 500
Query: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843
+Q QEA + L + L Q +E +++ Q+L ++ Q + + + ++ D
Sbjct: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
Query: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
+ L Q+ + L + H Q +++ L ++L ++++ +L+ R+ E+ L
Sbjct: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEEL 620
Query: 1904 LALQQQCAEQ-------------AQEHEVETRALQDSWLQAQ-------AVLKERDQELE 1943
++ + + +E E E R L+ + + + V + E E
Sbjct: 621 SRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENE 680
Query: 1944 ALRAESQSSRHQEEAARAR-----------AEALQEALGKAHAALQGKEQHLLEQA---- 1988
L + RHQ E A E L+ G+ A L ++ LLE+A
Sbjct: 681 KLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE 740
Query: 1989 ----ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
ELS + +T+ LQ + +++ + + + I+ D ++E L +L
Sbjct: 741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 800
Query: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLA 2104
++ + + ++E +EK L +R + +E Q + EI L Q++ E +L
Sbjct: 801 EEQKQLTQLINKKEIFIEK-LKER-SSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLG 856
Query: 2105 QK-------EQEILELRETQQRNNLEALPHS-HKTSPMEEQSLKLDSLEPRLQRELERLQ 2156
++E+ LRE Q R A P + + + + +L++++ L+ E++ Q
Sbjct: 857 SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQ 916
Query: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216
+ +++ + Q+ + + + + L LE+D E + LQ +E
Sbjct: 917 KIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL---FLEKDEEIKSLQKTIE 973
Query: 2217 LTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSW-RQRLEHL 2275
+ L +ER ++ + Q +V + E +G EK + E L
Sbjct: 974 QIKTQLHEER---------QDIQTDNSDIFQETKVQSLNIE---NGSEKHDLSKAETERL 1021
Query: 2276 QQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI----SKATAS 2331
+ + E++ L N+ L ++Q+ ++ + + Q LEI ++ +++
Sbjct: 1022 VKGIKERELEIKLLNEKNISLTKQIDQLSKDE---VGKLTQIIQQKDLEIQALHARISST 1078
Query: 2332 SPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSL 2391
S TQ +VV LQ QL +++ + +RE + L
Sbjct: 1079 SHTQ-------------------DVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119
Query: 2392 SHSLLAVAQAPEATV--LEAETRRLDESLTQS 2421
H ++ + A EA + L+ E ++L S
Sbjct: 1120 -HKMMDIVAAKEAALIKLQDENKKLSTRFESS 1150
Score = 127 bits (318), Expect = 2e-28
Identities = 240/1249 (19%), Positives = 523/1249 (41%), Gaps = 151/1249 (12%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQA-TLVRKL 59
+E + LN + L+ E + L Q Q A +K+ QQ + +++ KL
Sbjct: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMIL---IKDQLSKQQNEGDSIISKL 532
Query: 60 QAKVLQYRSWCQELEK-RLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRCESLAEVN 117
+ + + +LE +++ T Q+ + ++ E L++L + ++ + + E+L +
Sbjct: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
Query: 118 TQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL 177
+ + N L+E + + + SR R+ELM+ +Q F LK +
Sbjct: 593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ-DSNSNFKDTLLKEREAEV 651
Query: 178 LSLWREVVTFRRHFLEMKSAT-----DRDLMELKAEHVR------LSGSLLTCCLRLTVG 226
+L + + + +K + + + L E VR L+G+ + T+
Sbjct: 652 RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV 711
Query: 227 AQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVT 286
+ G + L AK + LE EA++ + + +L + +L + LQ
Sbjct: 712 ETLKMEKGE--------IEAELCWAKKRLLE-EANKYEKTIEELSNARNLNTSALQ---L 759
Query: 287 ELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIK 346
E L+ +QK++ + I L++ +E ++T+H E + LS + +E+K Q + K
Sbjct: 760 EHEHLIKLNQKKDME----IAELKKNIEQMDTDHKETKD---VLSSSLEEQKQLTQLINK 812
Query: 347 DITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD-YQDADKALTLVRSVLTRRRQAVQDL 405
++ +E+ E S + + D Y A + ++R + + +++ +
Sbjct: 813 --KEIFIEK------------LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSM 858
Query: 406 RQQLAGCQEAVNLLQQQHDQWE--EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK 463
+++ QE + L+++ + + K L + +L E L L+ E+ K
Sbjct: 859 KEENNHLQEELERLREEQSRTAPVADPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQK 917
Query: 464 ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE-RE 522
E +++ +L Q L+ ++E R + ++ +K+E+ + L + + +
Sbjct: 918 IIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT 977
Query: 523 RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582
+L E ++ S+ E +E+ + +L + E + + E I L+
Sbjct: 978 QLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE 1037
Query: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE-ENQSVCSRMEAAEQARN 641
+L ++ + L+ D+VG Q++Q ++ E Q++ +R+ + ++
Sbjct: 1038 KNISLTKQI--------------DQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD 1083
Query: 642 A------LQVDLAEAEKRREALWEK---NTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
LQ E EK L EK N+HL+ + K + A +A L +Q+E +++
Sbjct: 1084 VVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKL 1143
Query: 693 QKKLSESRHQQEAATTQ-LEQLHQEAKRQEEVLARAVQ---------------------E 730
+ S T Q L ++ +E + + L++ Q +
Sbjct: 1144 STRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQ 1203
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
E L++E+ L+ +++ +E +Q + +Q + L+ L + Q Q V +L
Sbjct: 1204 FEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL 1263
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ----------ERDAAARQLAQAEQEG 840
+V + Q+ E + +++ EL + Q + D + QL+ A
Sbjct: 1264 QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLT 1323
Query: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
+ E +A+ + +++ E QQEL + +SL+ + + + ++
Sbjct: 1324 PQSAECLRASKSEVLSESSELL-------QQELEELRKSLQEKDATIRTLQENNHRLSDS 1376
Query: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA-SQQL----ERLRQDM 955
I A E ER + E +++ KE+ +L+ LL+ + L A S QL E +
Sbjct: 1377 IAATSELERKEHEQT--DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
Query: 956 KVQKLKEQETTGILQT---------QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
+L Q T + + +L+ ++ E R + ALQE +
Sbjct: 1435 NENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR 1494
Query: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
+ + + +K + +A ++L++++ Q K T E N++ ++ + + E++Q
Sbjct: 1495 EKEFECHSMKEKALA---FEQLLKEKEQGK---TGELNQLLNAVKSMQEKTVVFQQERDQ 1548
Query: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE 1126
+L L++ +Q E +AL+ ++Q + ++ + ++E LR + E E D +EA E
Sbjct: 1549 VMLALKQ----KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESE-DSYTREALAAE 1603
Query: 1127 ELEAS-----HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
+ EA + E++L +S A E + Q +++ S + QL ++ ++
Sbjct: 1604 DREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQR 1652
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 214 bits (544), Expect = 1e-54
Identities = 501/2509 (19%), Positives = 1034/2509 (41%), Gaps = 379/2509 (15%)
Query: 22 EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR----------KLQAKVLQYRSWCQ 71
EQ+ +Q +AE ++ K+ + +A +V K +A+V Y+ +
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
LEK A + + E E +LL EEE + + E+ + R+++EK
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKLK--- 656
Query: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
+ L + + + D L + SQ +F K L + +L+
Sbjct: 657 -------DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI------------- 696
Query: 192 LEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249
LE+ D + L+ K+E + L + L + + Q + G+ + +E L
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEKGTLEQEVQE------L 748
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL----TQSQKQNEDYEKM 305
KT+ LEK+ E+ +L + +Q + E + L+D L +L SQ++ +
Sbjct: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
Query: 306 IKA------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359
IK+ + +EIL + +L + L+ ++++ + K+ E +
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 360 AQGSGHENSLELDSSIFSQFDYQDADKALT--------------LVRSVLTRRRQAVQDL 405
A ++ LE DS + +Y+ KAL + SV + V +
Sbjct: 869 ACLLKVKDDLE-DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
Query: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465
+ ++ L ++ + + E L QRL L+ + G+ L EV SL +E+
Sbjct: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK 987
Query: 466 ELLQKAREELR--------QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ--EELH 515
E + EL + ++ + + L V + +G K + EE
Sbjct: 988 EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
Query: 516 LAVRERERLQEMLMGLEAKQSE-------SLSELITLR--EALESSHLEGEL--LRQEQT 564
+ V ++ + M +G E+KQ + S+++ +LR + E+ L+ EL L+ EQ
Sbjct: 1048 IMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE 624
++ + A++ L S + + L +L E L + +++ +L++
Sbjct: 1108 DLRLQM-EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQK 1163
Query: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL------------------EA 666
+Q M+ E + L K ++A+ E+ ++ E
Sbjct: 1164 IHQLELQTMKTQETGDEGKPLHLL-IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEV 1222
Query: 667 QLQKAEEAG--------AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
+ E +G ELQ ++Q+ +E + L++ + +L +
Sbjct: 1223 NAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWG 1282
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE-AQ 777
+Q + + E+ E L + Q + D+ + + LSS ++L ++ L E Q
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK-LSSLQDLEKTKLEEQVQ 1341
Query: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
+ S+I + QL+ + ++ + E+ CL+ L S++ + E
Sbjct: 1342 ELESLISSLQQQLK-------ETEQNYEAEIHCLQKRLQAV-SESTVPPSLPVDSVVITE 1393
Query: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMR------- 890
+ + + +K ++ E + + + K LE +E++E E+
Sbjct: 1394 SDAQRTMYPGSCV-KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
Query: 891 -LKEQQTEMEAIQAQREEERTQAES-ALCQ--------MQLETEKERVSLLETL-LQTQK 939
QQTE+ I +E + ++ A+CQ M+L ++ ET+ ++ ++
Sbjct: 1453 IAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
Query: 940 ELADASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
E S++L E L + + E + + ++ ++ + + D+++
Sbjct: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS 1572
Query: 995 QEESSSLLQDKMDLQKQVEDLKSQLVA-----QDDSQRLVEQEVQEKLRETQEYNRIQKE 1049
++S L M ++Q+ED++ +LV Q ++ L + +++ R+ ++ ++Q+E
Sbjct: 1573 SMDASRQL---MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEE 1629
Query: 1050 LER------EKASLTLSLMEKEQRLLVLQEADSIRQQEL-------------SALRQDMQ 1090
++R +++S+ + E+ ++L+E ++++Q L S Q+
Sbjct: 1630 IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
Query: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
E QGE +E + + + L ++ ++ + L+ E L++ + L+ L + AA
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK-----ANNRLLKILLEVVKTTAA 1744
Query: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ESRPELSGGG-- 1207
+ R L+ + Q + AS+ S + + V ES P SG
Sbjct: 1745 VEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
Query: 1208 DSAPSVW------GLEPDQNGARSLF-------KRGPLLTALSA----------EAVASA 1244
+ ++W G E Q RS F + L+ +S+ EA++
Sbjct: 1805 RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET 1864
Query: 1245 LHKL-HQDLWKTQQTRDVLRDQ---------VQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
+L H + +T+ R+ R + ++L ERL + + Q+ EL + +
Sbjct: 1865 SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
Query: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
+EK+ +E + + L + + +RL+ E ++ + Q ERELL KE +
Sbjct: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK 1984
Query: 1355 A-----------QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE-----VESE 1398
A + E L +E + QA + +DL+ AL++ EE +E E
Sbjct: 1985 AEAGPVEQQLLQETEKLMKEKLEVQCQAEK---VRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-------- 1450
+E+ L + + A K L++ L + +RE E + + +IQ+LE+Q
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQ 2101
Query: 1451 --REMQKAALELLSLDLKKRN---QEVDLQQEQIQ-ELEKCRSVLEHLPMAVQEREQKLT 1504
E Q +E L+ LK++ E+ L +EQ+Q ++++ +E L V+E EQ L
Sbjct: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
V + +++E DR+ V L LE + ++++R + +K++ LE +LE+
Sbjct: 2162 VSADTFQKVE-DRKHFGAVEAKPELSLEVQ---LQAERDAIDRKEKEITNLE---EQLEQ 2214
Query: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ----ELQAQSSQIHDLESHST- 1619
++E + + +++L Q E Q+ T +LE+ ++ +++ I + ++ ST
Sbjct: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274
Query: 1620 -------VLARELQERDQEVKSQREQIEELQRQ------------KEHLTQDLERRDQEL 1660
A+ +QE++ E+ EQ+ +LQ+Q K L +DLE + + L
Sbjct: 2275 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2334
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720
M +E ++ ++ Q L E +E+++ L G++ + + E A+
Sbjct: 2335 MSDQECVKRNREEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEAD--------- 2382
Query: 1721 RGSLEH-MKLILRDK---EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
SL+H + +++ +K E++VE E E+ +K+ L+ ET+ ++Q
Sbjct: 2383 --SLKHQLDVVIAEKLALEQQVETANE---EMTFMKNVLK-----------ETNFKMNQL 2426
Query: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--EALQQEQQQA--QGQ 1832
QE+ L+++ + + + E S+ +D + + + L +AL+ + Q +
Sbjct: 2427 TQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF 2486
Query: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
EE K L+ L Q T+ + EL +Q + ++E+ E + L++ + +L
Sbjct: 2487 EENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---TEMLQKKIVNL 2543
Query: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS 1952
+ E+ A L Q Q E QE+ + QD+ + + Q L LR + S
Sbjct: 2544 QKIVEEKVAAALVSQIQ-LEAVQEY---AKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
Query: 1953 RHQEEAARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEASTATLQASLDACQA 2010
A R L+ + + H + L+ ++ + E+ L + E LQ L+ +
Sbjct: 2600 --DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK--EKKLLELQKLLEGNEK 2655
Query: 2011 HSRQLEEALRIQEGEI---------QDQDLRYQEDVQQLQ-QALAQRDEELRHQQEREQL 2060
R+ E+ Q+ E+ +++ + +++ L+ +++A + E ++++ E+L
Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715
Query: 2061 LEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN 2120
E+ L + + NM +++L Q R+ H + + +L++ +KE E E++E+++
Sbjct: 2716 QEELLVK--ETNMTSLQKDLSQVRD-------HLAEAKEKLSILEKEDE-TEVQESKKAC 2765
Query: 2121 NLEALP--HSHKTSPMEEQSLKLDSLEPRLQRELE------RLQAALRQTEAREI----- 2167
E LP S + + +LK+ S Q ++ LQ+ E EI
Sbjct: 2766 MFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFT 2825
Query: 2168 EWREKAQDL----ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
E EK Q+L L + S + + ++ +L+ + + + ++
Sbjct: 2826 EKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2885
Query: 2224 KERLHSPGATSTAEL-----GSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
L A T E+ GS QG+ L G + G E +S
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2934
Score = 197 bits (500), Expect = 1e-49
Identities = 464/2377 (19%), Positives = 966/2377 (40%), Gaps = 372/2377 (15%)
Query: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV-------TELSALLTQSQKQNED 301
L K E+E+ E + + ++G + E + + T+L+A L Q++++ ++
Sbjct: 164 LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE 223
Query: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT--QVMVEEGDNI 359
+ L E + L+ +L E + L Q + I Q +EE D++
Sbjct: 224 TMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHL 283
Query: 360 AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV---QDLRQQLAG---CQ 413
+ DYQ + T+ S L + + QD + + + Q
Sbjct: 284 LE------------------DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
E ++++ + + EE K + KLT D L G+ + +++QK +E
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLT-TADKLLGEL------------QEQIVQKNQE 372
Query: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK---EEQQEELHLAVRERERLQEMLMG 530
+LE+ + + QL G + QK ++ Q E + R + Q L
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432
Query: 531 LEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
L A+ E + ++ +++ L H+ + + +T + A +S + ++ +E+ +K
Sbjct: 433 LRAELDEMYGQQIVQMKQELIRQHMAQ--MEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
Query: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
+ +KL N K L ++L + EE C+ E L +
Sbjct: 491 MNVAINELNIKLQDTNS----QKEKLKEELGLILEEK---CALQRQLEDLVEELSFSREQ 543
Query: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
++ R+ + E+ + L + K+ +L+A++ E ++E++ K H+ E +
Sbjct: 544 IQRARQTIAEQESKLN-EAHKSLSTVEDLKAEIVSASESRKELELK-----HEAEVTNYK 597
Query: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS-----S 764
++ L K + VL R + +EA + +R Q + ++L++ + L +
Sbjct: 598 IK-LEMLEKEKNAVLDRMAESQEAELER-----LRTQLLFSHEEELSKLKEDLEIEHRIN 651
Query: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL----DTERS 820
++L ++ +QQ I+ + ++ +I+T+ K+ + + L LE+ D ++S
Sbjct: 652 IEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708
Query: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
+ + Q+ + ++E + ++ EKE L ++ QEL E L
Sbjct: 709 LVNSKSEEMTLQINELQKEIEILRQE-----EKEKGTLEQE--------VQELQLKTELL 755
Query: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
E++ E E L+E+ ++EA + ++E+ E L +++ER+ L+++ K+
Sbjct: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815
Query: 941 LADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ +++E L +D+K Q ++ L ++++ + A + + LQEE
Sbjct: 816 -SVWEKEIEILIEENEDLKQQCIQ-------LNEEIEKQRNTFSFAEKNFEVNYQELQEE 867
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ LL+ K DL +DS+ E E + KL+ E +Q+ + +
Sbjct: 868 YACLLKVKDDL--------------EDSKNKQELEYKSKLKALNEELHLQR-INPTTVKM 912
Query: 1058 TLSLMEKEQRLLV-LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK--E 1114
S+ ++++ + E + +++ + L + ++ + E+ ELS ++ L +++K+K E
Sbjct: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
Query: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
FL +E + L++ + Q+ LR R +LE + + N
Sbjct: 973 ISFLNEEVKSLKQ--------------------EKEQVSLRCR----ELEIIINHNRAEN 1008
Query: 1175 QAQAQAQLASLYSAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQN---GARSL 1226
Q++SL + + A GSV S+ S G +S V +N G S
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSV--SKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 1227 FKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
++ L L +++ E+ A D K Q+ +VL+ + L ++ S V+
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSEND--KLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
Query: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ--GE 1342
+ D R+ +N+++K+ SL+ EL+ E ++ + ELQ M+ Q G+
Sbjct: 1125 STHVDQVREYMENEKDKALC-----SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
Query: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+L +A E + ++ L + + E A + ED + + +NE
Sbjct: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYIS-ENE 1238
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE-KQRE 1452
+ E + R + Q + K +E LL L R ++ + +LE +
Sbjct: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL--VLQTRLSKIWGQQTDGMKLEFGEEN 1296
Query: 1453 MQKAALELLSLDLKKRN-QEVDLQQE----QIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507
+ K E LS+ + N +++D+ + +Q+LEK + L VQE E ++ +
Sbjct: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK-----LEEQVQELESLISSLQ 1351
Query: 1508 EQIRELEKDRETQRNVLEHQLLELEKK----DQMIESQRGQVQDLKKQLVTLECLALELE 1563
+Q++E E++ E + + L+ +L + + ++S D ++ + C+ ++
Sbjct: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
Query: 1564 -----ENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLEERSQ----------ELQ 1605
++ + ++K LE Q + Q VA +++ + Q E
Sbjct: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
Query: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH--LTQDLERRDQELML- 1662
A S Q H + E++ ++ Q + +++ ++E L+++L +E++L
Sbjct: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLS 1531
Query: 1663 ---------QKERIQVLEDQRTRQTK--ILEEDL-EQIKLSLRERGRELTTQRQLMQERA 1710
K+ + + ++ + K I+ + + ++I +S + R+L + +++
Sbjct: 1532 NSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
Query: 1711 EEGKGPSKAQRGSLEHM---KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
+E R EH +L+ + +++E Q+E +LQE +L +QL R
Sbjct: 1592 QE------LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL--AQRSSI 1643
Query: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
+ L+S+RE+ VL ++L+ ++ + L +L R+ + +
Sbjct: 1644 DNENLVSERER---VLLEELEALKQLSLAGREKLCCEL---------RNSSTQTQNGNEN 1691
Query: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Q + +E+ KEK + + ER+ LQ + ++ E+ + A+EE
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYA-LQKANNRLLKILLEVV---KTTAAVEE 1747
Query: 1888 -----VLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDS------------- 1927
VLG L S+ Q A L + + + HE TR +S
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
Query: 1928 ---WLQAQAVLKERDQEL------------------------------EALRAESQSSRH 1954
W + E Q L + L A S++S
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867
Query: 1955 QEEAARARAEALQEALGKAHAALQGKE------QHLLEQA----ELSRSLEASTATLQAS 2004
E A + E ++E+ + A + + + L E++ +L+ L + +
Sbjct: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
Query: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
D RQ++E I + +Q+L + Q +A Q+ +E R R++ K+
Sbjct: 1928 ADEKTLFERQIQEKTDIIDR--LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Query: 2065 LAQRVQENMIQEKQNLGQEREE-----EEIR-GLHQSVRELQLTLAQKEQEILELRETQQ 2118
A V++ ++QE + L +E+ E E++R L + V+ L++ + E+++ E +Q
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSRFIELEQ 2042
Query: 2119 RNNLEALPHSHKTSPMEEQSLKL---------------DSLEPRLQRELERLQAALRQTE 2163
N E + + +E+Q K+ D + +Q+ ++L+ R
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
Query: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL- 2222
E + RE + LA L + S L LQ + ER+ E ++L+ + +AL
Sbjct: 2103 ISEHQTRE-VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 2223 --------EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEH 2274
++R H + EL + + + E E + + + +R+ LE+
Sbjct: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
Query: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPT 2334
+ V +L + +L+ + + L+++E+E + K + + L I ++ A S
Sbjct: 2222 KNEEVQQLHM---QLEIQKKESTTRLQELEQENKLFKDDMEKL----GLAIKESDAMS-- 2272
Query: 2335 QQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHS 2394
QD A+ + E + E+ L Q+T + Q+Q IT + E L L
Sbjct: 2273 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVT--KLQQQLKITTDNKVIEEKNELIRDLETQ 2330
Query: 2395 LLAVAQAPEATV--LEAETRRLD---ESLTQSLTSPG 2426
+ + E E E +L+ E L Q L + G
Sbjct: 2331 IECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
Score = 191 bits (485), Expect = 8e-48
Identities = 494/2349 (21%), Positives = 931/2349 (39%), Gaps = 391/2349 (16%)
Query: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALR-------------- 310
+L S DLEK +L+++V EL +L++ Q+Q ++YE I L+
Sbjct: 1324 KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPS 1383
Query: 311 ---ETVEILETNHTELMEHEASLSRNAQE--------------------EKLSLQQVIKD 347
++V I E++ M + + +N EK +Q+ ++
Sbjct: 1384 LPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE 1443
Query: 348 ITQVMVEEGDNIAQ-------GSGHENSL---------ELDSSIFSQFDYQDADKALTLV 391
+ +V+V AQ G EN+ + + F++
Sbjct: 1444 VAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF 1503
Query: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTLAGQ 450
+V + ++ + L ++L + + L HD E + L + + ++ + Q
Sbjct: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563
Query: 451 TVDLQGEVDSLSKERELL--QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508
++ + V S+ R+L+ ++ E++RQ+L QE + EL Q Q +++
Sbjct: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQ 1619
Query: 509 -EQQEELHLAVRE--RERLQEMLMGLEAKQSESLSELITLREALESSHLEG-ELLRQEQT 564
E QE+L ++ R+ Q + E SE L+ EAL+ L G E L E
Sbjct: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
Query: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-NEALALDKVGLNQQLLQLE 623
+ ++ E+ E T K + D + V L NE AL K N +LL++
Sbjct: 1680 NSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKIL 1735
Query: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
E V A E+ + + + + ++ A L EA A +++ +
Sbjct: 1736 LE---VVKTTAAVEETIGRHVLGILDRSSKSQS--------SASLIWRSEAEASVKSCVH 1784
Query: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
EE + ES + ++ +K EE + + LVR A
Sbjct: 1785 ------EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE----GTELSQRLVRSGFAGT- 1833
Query: 744 RLQAVERDRQDLAEQLQG-LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
++ + ++L + L +A E L ++ E Q +VT Q E+ ++ Q +E
Sbjct: 1834 ---EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT--QTELMRESFRQKQE 1888
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862
+ ++C + EL + + R+ A +L++AE +K E+++
Sbjct: 1889 ATES-LKCQE-ELRERLHEESRAREQLAVELSKAEGV-IDGYADEKTLFERQI------- 1938
Query: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALC 917
QE ++ LE+E + RL+E + E + IQ +RE +E +AE+
Sbjct: 1939 --------QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 918 QMQL--ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975
+ QL ETEK LE Q +K D +Q++ L D++ Q + E T+L +
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 976 AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-------QDDSQRL 1028
+++ + +Q L E++ ++ Q++++ L+ QL + R
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 1029 VEQ----------EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
VEQ + E L ++ R +E E L + E EQ LLV AD+ +
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV--SADTFQ 2168
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL---LEELEASHITE 1135
+ E EA+ E L Q++ R + KE + E QL EELE +
Sbjct: 2169 KVE-DRKHFGAVEAKPE-LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEV 2226
Query: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
QQL QL+++ + + ++L+ L E + L+ + LG
Sbjct: 2227 QQLH----------MQLEIQKKESTTRLQELEQENK-------------LFKDDMEKLGL 2263
Query: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT 1255
+ +S DQ+ F + + + + + KL Q L T
Sbjct: 2264 AIKESDAMS------------TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2311
Query: 1256 ------QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
++ +++RD ++E ++D E K E++ L + + Q+E + G++
Sbjct: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN-IGQKT 2370
Query: 1310 SLESELMELHETMASLQSRL------RRAELQRMEAQGE-----RELLQAAKENLTAQVE 1358
S+ + L E SL+ +L + A Q++E E + +L+ + +
Sbjct: 2371 SMNAH--SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2428
Query: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVE--SERERAQALQEQGELKVAQ- 1415
L + E + I E + A L E+E + ++L+ Q K +
Sbjct: 2429 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2488
Query: 1416 -GKA----LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470
GK L+ L L T++ ++ E+ QI+++++Q + + L+ ++L+K +
Sbjct: 2489 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2548
Query: 1471 E-------VDLQQEQIQELEK-CRSVLEHLPMAVQEREQKLTVQR-EQIRELEKDRETQR 1521
E +Q E +QE K C+ + ++ +Q Q+RE E +
Sbjct: 2549 EKVAAALVSQIQLEAVQEYAKFCQD-----NQTISSEPERTNIQNLNQLREDELGSDISA 2603
Query: 1522 -----NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLI 1576
+ LE Q++E+ + ++ QV+ +K ++ E LEL++ +E +K
Sbjct: 2604 LTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQK---LLEGNEKKQ 2657
Query: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
+E E +R Q V + T +L ++E +++ L + S EL ++ + +
Sbjct: 2658 REKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
Query: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED----LEQIKLSL 1692
E++ + L +DL + L KE++ +LE + +T++ E E + + L
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILE--KEDETEVQESKKACMFEPLPIKL 2774
Query: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
+ + +Q + + + P + + + L + EC E + E+
Sbjct: 2775 ---SKSIASQTDGTLKISSSNQTPQILVKNAGIQINL-------QSECSSEEVTEIISQF 2824
Query: 1753 DQLEQQLQGLH---------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--QSL 1801
+ +++Q LH R + ET L +RE + V Q L+E E G LK Q L
Sbjct: 2825 TEKIEKMQELHAAEILDMESRHISETETL--KREHYVAV--QLLKE--ECGTLKAVIQCL 2878
Query: 1802 QSQLDEAQRALAQRD--QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
+S+ + LA D Q E + GQ ++T H
Sbjct: 2879 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ----------------GIYLT----HS 2918
Query: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
+ D + R E E A + +++ G LRA E + +L+L + ++H +
Sbjct: 2919 QGFDIASEGRGEESESATD----SFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDHSI 2973
Query: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA-EALQEALGKAHAALQ 1978
+ + + WL+ + L+ L + Q R E +++ E+ + G+ ALQ
Sbjct: 2974 Q--QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031
Query: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ 2038
Q LE+ + + + T + DA L E IQ+Q + YQ ++
Sbjct: 3032 ---QVFLEERSVLLAAFRTELTALGTTDAV--------GLLNCLEQRIQEQGVEYQAAME 3080
Query: 2039 QLQQA----LAQRDEELRHQQ-------EREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
LQ+A L + L Q +REQ EK +Q + E IQ+KQ+ E +
Sbjct: 3081 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKP-SQELLEYNIQQKQSQMLEM-QV 3138
Query: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE---ALPHSHKTSPMEEQSLKLDSL 2144
E+ + ELQ L+ ++ + EL+ + LE L HK E ++ +L+
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVK 3197
Query: 2145 EPRLQRELERLQAALRQTEAREIEW----------------REKAQDLALSLAQTKASVS 2188
+ + L A Q ++RE++W +E+ +DL SL K
Sbjct: 3198 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ--R 3255
Query: 2189 SLQEVAMFLQASVLERDSEQ----QRLQDELELTRR---------ALEKERLHSPGATST 2235
+LQ + Q L +S+Q QR+ + +L+ LE E++ +ST
Sbjct: 3256 NLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSST 3315
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
+ +Q + +G P P + +++LE + L + + + ++Q
Sbjct: 3316 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3375
Query: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
R +Q+E++R ++ + T + + + GQK + ELQ +
Sbjct: 3376 TR---QQMEKDR----------------QVHRKTLQTEQEANTEGQKK-----MHELQSK 3411
Query: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415
V LQ Q LE K++Q Y + + L G+ L + E+ + + L+
Sbjct: 3412 VEDLQRQ--LEEKRQQVY--KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ--NLN 3465
Query: 2416 ESLTQSLTS 2424
E T SLTS
Sbjct: 3466 EPTTWSLTS 3474
Score = 173 bits (438), Expect = 2e-42
Identities = 396/1958 (20%), Positives = 803/1958 (41%), Gaps = 307/1958 (15%)
Query: 69 WCQELEKRLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRC-----ESLAEVNTQLR- 121
W + E+ E + + + E +P +EL++ + Q E+++E ++QL
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
Query: 122 LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181
+ + +++ ++ R+ E + + ++EL + + +E L G +
Sbjct: 1871 AKVTQTELMRESFRQKQE--ATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
Query: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
E F R E DR EL RL Q E + R
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRL---------------QELEAEQQQIQEER 1973
Query: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
E LL + + ++ EA Q+L+Q + EK E+Q Q++K +D
Sbjct: 1974 E-----LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ----------CQAEKVRDD 2018
Query: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
+K +KAL VE + EL + + + + +++ +L++ ++ + + + E+ +
Sbjct: 2019 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--- 2075
Query: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
E + +F +Q +Q L QQL + V Q
Sbjct: 2076 -------REHERDVF----------------------QQEIQKLEQQL----KVVPRFQP 2102
Query: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
+ E + L L++ T + L LQ ++ ++E E L+ EL Q L V
Sbjct: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 482 LEQEAWRLR------------RVNVELQLQGD------------SAQGQKEEQQEELHLA 517
++ +++E+QLQ + + + Q E+ +EEL
Sbjct: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE-- 2220
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSI 577
+ E +Q++ M LE ++ ES + L L + E +L + + ++ A+ ++S
Sbjct: 2221 -NKNEEVQQLHMQLEIQKKESTTRLQELEQ-------ENKLFKDDMEKLGLAI---KESD 2269
Query: 578 AELSSSENTLKTEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636
A + ++ L + A + + V++ LNE +V QQ L++ +N+ + + E
Sbjct: 2270 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNE-----QVTKLQQQLKITTDNKVIEEKNELI 2324
Query: 637 EQARNALQVDLAEAE----KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
++ +++ E R E + + N +E Q+ G + + + EE + +
Sbjct: 2325 RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384
Query: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA-------VQEKEALVREKAALEVRL 745
+ +L ++ A Q+E ++E + VL QE +L RE+ ++E ++
Sbjct: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KI 2443
Query: 746 QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Q++ + ++A + LS K LE L E ++ + Q + +I
Sbjct: 2444 QSIPENSVNVA--IDHLSKDKPELEVVLTE-----DALKSLENQTYFKSFEENGKGSIIN 2496
Query: 806 GEVRCLKLEL-----DTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR 859
E R L+LE D E +Q +Q +D + + E K + QK EK L
Sbjct: 2497 LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALV 2556
Query: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
+ + E QE AK + + E E +T ++ + RE+E SAL
Sbjct: 2557 SQIQLEAV---QEYAKFCQDNQTISSEPE------RTNIQNLNQLREDELGSDISALTLR 2607
Query: 920 QLETEKERVSLLETLLQTQKELADASQQ-LERLRQDMKVQKL------KEQETTGILQTQ 972
E E + V + +L+ ++++ A + LE+ ++ +++QKL K++E Q
Sbjct: 2608 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2667
Query: 973 LQEAQRELKEAARQHRD-----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
E + E + + +L AL+ ES + + +++ E L+ +L+ ++ +
Sbjct: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
Query: 1028 LVEQE---VQEKLRETQE-YNRIQKELERE-----KASLTLSLMEKEQRLLVLQEADSIR 1078
++++ V++ L E +E + ++KE E E KA + L K + + Q +++
Sbjct: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2787
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE-------ELEAS 1131
+ Q + + G Q ++ Q E +EV E + F + ++ E ++E+
Sbjct: 2788 ISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
Query: 1132 HITEQQ-------LRASLWAQEAKAAQLQLR-LRSTE-SQLEALAAEQQPGNQAQAQAQL 1182
HI+E + + L +E + ++ LRS E S + LA + +
Sbjct: 2846 HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS 2905
Query: 1183 AS-----LYSALQQALGSVCESRPELSGGG-DSAPS-VWGLEPDQNGARSLFKRGPLLTA 1235
S +Y Q E R E S DS P + GL R++ G + +
Sbjct: 2906 GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGL------LRAVHNEGMQVLS 2959
Query: 1236 LSAEAVASAL-HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
L+ + H + Q + R + + L++ +T + ++ E+ D
Sbjct: 2960 LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE---AEVYDS---- 3012
Query: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE---LLQAAKE 1351
SQ+ E S W G+ L+ L + +S L A + A G + LL ++
Sbjct: 3013 SQSHESFSDWRGEL------LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ 3066
Query: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411
+ Q QAA+ E +A +L E ++ + + + ++ E+E + QE E
Sbjct: 3067 RIQEQGVEYQAAM-ECLQKADRRSLLSE-IQALHAQMNGRKITLKREQESEKPSQELLEY 3124
Query: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
+ Q ++ + E + E+ +++ + EL++Q +K + L +L + E
Sbjct: 3125 NIQQKQS----------QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3174
Query: 1472 VDL----QQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
++ Q + ++ELE R ++ V L ++++ REL+ LE +
Sbjct: 3175 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW-------ALEKE 3227
Query: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
+L + + E + +++DLK L + + L+L + +E Q++L+ E + + E+QR
Sbjct: 3228 KAKLGRSE---ERDKEELEDLKFSLESQKQRNLQL---NLLLEQQKQLLNESQQKIESQR 3281
Query: 1588 VALTHLTLDLEERSQELQA--QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ 1645
+ + + R+ ELQ +S ++ E ST+ +R++E+ +Q + + +
Sbjct: 3282 MLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL------DRERELHAQLQSSDGTGQS 3335
Query: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
+ L + L KE + LE++ +R ++L E E+ KL + +++ RQ+
Sbjct: 3336 RPPLPSE--------DLLKELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQV 3386
Query: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
H K + ++E E Q++ +HELQ + L++QL+ ++
Sbjct: 3387 --------------------HRKTLQTEQEANTEGQKK-MHELQSKVEDLQRQLEEKRQQ 3425
Query: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
V + L QR Q I+ Q+ + RE+ + L L+E D+ + Q+
Sbjct: 3426 VYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3484
Query: 1826 QQQAQGQEERVKEKADALQGA------LEQAHMTLKERHGELQDHKEQA-RRLEEELAVE 1878
+ + + +E + + G LE L+ +LQ ++A RL+ E A +
Sbjct: 3485 KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADD 3544
Query: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
+ E + ++ +L LQ+ +Q +E
Sbjct: 3545 EDFIWVQENI-----------DEIILQLQKLTGQQGEE 3571
Score = 145 bits (366), Expect = 5e-34
Identities = 280/1392 (20%), Positives = 590/1392 (42%), Gaps = 194/1392 (13%)
Query: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
E E E + Q E+ + LE ++ +Q E EA QR+ TQ + L Q
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 920 QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979
+ E ++ L EL + SQ+L+ Q ++ + T L +A+++
Sbjct: 218 RREKDETMREFL--------ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
Query: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
+ H+ L EE LL+ D QK+ ED Q+ + ++ E E +K+
Sbjct: 270 I----LTHQQQL----EEQDHLLE---DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
Query: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
+ + +KE E+ L ++E+E++ L L++ + + L L++ + + E K +
Sbjct: 319 SNKEEIQEKETIIEE--LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
Query: 1100 SAQMELLRQEVKEKE-ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
++EL + KE++ ++ + Q +EEL+ + + Q + +Q +
Sbjct: 377 --KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI---------VQRMEQE 425
Query: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG--- 1215
T+ +LE L AE ++ Q + ++Q + + E + G ++A +
Sbjct: 426 TQRKLEQLRAEL---DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
+ DQ + + A+++L+ L T Q +KL+E L
Sbjct: 483 VNEDQ-----------------IKLMNVAINELNIKLQDT-------NSQKEKLKEELGL 518
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
EK + +L+DL +LS ++E+ + ES+L E H+++++++ L+ +
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED-LKAEIVS 577
Query: 1336 RMEAQGERELLQAAK-ENLTAQVEHLQA---AVVEARAQASAAGILEEDLRTARSALKLK 1391
E++ E EL A+ N ++E L+ AV++ A++ E +L R+ L
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-----EAELERLRTQLLFS 632
Query: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
+EE S+ + ++ + + + L++NL + +++++ L+ ++ + +
Sbjct: 633 HEEELSKLKEDLEIEHRINI-----EKLKDNLGI------HYKQQIDGLQNEMSQKIETM 681
Query: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
+ +K L + Q + I E+ K + + + L V + +++T+Q +++
Sbjct: 682 QFEKDNL-------------ITKQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQ 725
Query: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
E+ + E ++ LE ++ EL+ K +++E Q + ++ +L+E +
Sbjct: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-------------DLQEKFAQ 772
Query: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD--LESHSTVLARELQ 1626
+E + ++K + ++ + + H + EER L + S+ D E +L E +
Sbjct: 773 LEAENSILK--DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
Query: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
+ Q+ E+IE+ + ++ E QE LQ+E +L+ + + +++LE
Sbjct: 831 DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE--LQEEYACLLKVKDDLEDSKNKQELE 888
Query: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
K L+ EL QR K + + K + + + E ++
Sbjct: 889 -YKSKLKALNEELHLQR--------INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQEAREQGELKEQSLQ- 1802
EL E + +++ L +++ + S L Q+ EI L ++ L++ +EQ L+ + L+
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999
Query: 1803 ----SQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERV-----KEKADALQGALEQAHM 1852
++ + Q Q L+ + + A+G +V +E ++ + +M
Sbjct: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059
Query: 1853 TLKERHGELQ---DH-----KEQARRLEE--ELAVEGRRVQALEEVLGDLRAESREQEKA 1902
T+ E + Q DH KE + R + E + + L+ DLR + Q
Sbjct: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
Query: 1903 LLALQQQCAEQAQEHEVETR-----ALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQE 1956
L + +Q +E+ + +L++ + AQ +E+ +EL+ + + E Q+ + QE
Sbjct: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQE 1176
Query: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
+ L +GK A+ + + L Q S E T L+ ++A + +
Sbjct: 1177 TGDEGK--PLHLLIGKLQKAVSEECSYFL-QTLCSVLGEYYTPALKCEVNA-EDKENSGD 1232
Query: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
++ E+QD Y+ +VQ Q+ + ++ + + +L+ L++ +
Sbjct: 1233 YISENEDPELQD----YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
Query: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
K G+E L ++E E L + Q NLE + +HK+
Sbjct: 1289 KLEFGEE------------------NLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSL 1328
Query: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Q L+ LE ++Q ELE L ++L+Q + +E E +A+ L S S++
Sbjct: 1329 QDLEKTKLEEQVQ-ELESLISSLQQ-QLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV 1386
Query: 2197 LQASVLERDSEQ 2208
+ E D+++
Sbjct: 1387 DSVVITESDAQR 1398
Score = 139 bits (349), Expect = 4e-32
Identities = 182/914 (19%), Positives = 400/914 (43%), Gaps = 91/914 (9%)
Query: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--------RQLSQNQEEKSKWE 1305
+T + ++LR++ +++ ++ A+ S H E+ + + +L++ EE
Sbjct: 126 RTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTY 185
Query: 1306 GKQ-----NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360
G + E+ + + + L + L++A ++ E E L + L Q + L
Sbjct: 186 GTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
QA+ + S+ DL A+ + +++E + + Q++ E Q LQ
Sbjct: 246 QASETLRNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 1421 ENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQ 1476
E + + E++++VE + + +IQE E E + E +L+LK + D
Sbjct: 303 EKIKVYEM---EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
Query: 1477 EQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQIREL-----------EKDRETQRNVL 1524
++QE + + ++++ + + +QK E+I++L KD + + +++
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
Query: 1525 EHQLLELEKKDQMIESQRG-----QVQDLKKQLVTLECLALELEENHHKMECQQKL---- 1575
+ E ++K + + ++ Q+ +K++L+ +E + HK E + L
Sbjct: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 479
Query: 1576 -IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
I E Q + VA+ L + L++ + + + ++ + L R+L++ +E+
Sbjct: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLE----QIK 1689
REQI+ ++ L + L ++ + +++ +R+ L+ + E +IK
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
L + E+ + R + AE + ++ E + + D E EH ++
Sbjct: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE------IEHRINIE 653
Query: 1750 ELKDQL----EQQLQGLHRKVGETSLLLSQREQEIVVLQQQL-QEAREQGELKEQSLQSQ 1804
+LKD L +QQ+ GL ++ + + + ++ Q QL E + +L++ + S+
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
+E + + +E+E L+QE+++ E+ V+E LQ E +KE+ +LQ
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE----LQLKTELLEKQMKEKENDLQ-- 767
Query: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRA 1923
E+ +LE E ++ + LE++L S+E+ L +++ + + E E+E
Sbjct: 768 -EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
Query: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
++ L+ Q + L E + R+ A E + L + +A L K +
Sbjct: 827 EENEDLKQQCI---------QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL-KVKD 876
Query: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
LE ++ + LE + L+A + + H +++ + + D+D + + ++ +
Sbjct: 877 DLEDSKNKQELEYK-SKLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
Query: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
+ + EL + E + + L+QR+ + Q KQ G EI L++ V+ L+
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG------EISFLNEEVKSLK--- 984
Query: 2104 AQKEQEILELRETQ 2117
+KEQ L RE +
Sbjct: 985 QEKEQVSLRCRELE 998
Score = 61.2 bits (147), Expect = 1e-08
Identities = 129/644 (20%), Positives = 261/644 (40%), Gaps = 70/644 (10%)
Query: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE---QAHMTLKERHGELQ 1862
+E Q+ L +L +Q + Q+ GQ K+K + + AH L +
Sbjct: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
Query: 1863 D-HKEQARRLEEELAVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
+ + ++R+E + E ++ L E+ + S E E + C+ +
Sbjct: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
Query: 1920 ETR-------------ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966
R + DS+ + A ++ LE + +E +H+ E E +
Sbjct: 124 VMRTGKPTNLLREEEFGVDDSYSEQGA--QDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1967 QEALG-KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQ 2022
+ G + LQ E + ++ + L A+ + D +L E L+IQ
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 2023 EGEIQ-DQDLRYQEDVQQLQQALAQRDEELRHQQ---EREQLLEKSLAQR----VQENMI 2074
++Q + LR L + + L HQQ E++ LLE ++ +Q + +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
Query: 2075 QEK---QNLGQERE-----EEEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEA 2124
QEK + Q+++ +EEI+ + EL + ++E++ LEL++ T L
Sbjct: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
Query: 2125 LPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
L E +++KL+ E + E+++L + + + R + + D+
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 2180 LAQ-TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR---ALEKERLHSPGATST 2235
+ Q T+ + L+ + L+ QQ +Q + EL R+ +E+ + G
Sbjct: 422 MEQETQRKLEQLR--------AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
A L S V ++ + + ++ Q + E L++ + + ++ LQR Q
Sbjct: 474 A-LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR---Q 529
Query: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL--- 2352
L +E++ R +++R A+ S ++++A S T +D + + S ++ EL
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQES-KLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 2353 -QKEVVLLQAQLTLERKQKQDYITRSAQTSR-ELAGLHHSLSHS 2394
+ EV + +L + K+K + R A++ EL L L S
Sbjct: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
Score = 59.7 bits (143), Expect = 3e-08
Identities = 137/677 (20%), Positives = 273/677 (40%), Gaps = 93/677 (13%)
Query: 124 MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183
++KAD ++L +++ L + + L R++ + QE + ++ + ++L + E
Sbjct: 3082 LQKAD--RRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3139
Query: 184 VVTFRRHFLEMKSATDRDLM---ELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--SGRM 238
+ + + E++ + M ELK+E + L T T+ AQ + + R+
Sbjct: 3140 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRL 3194
Query: 239 DGREPAQLLLLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRVTELSALLT 293
+ ++ + LL T E++ Q E +L + +K EL+D L +
Sbjct: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
Query: 294 QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
++ + N E+ + L E+ + +E+ M ++A LS Q L LQ V+ + +V +
Sbjct: 3255 RNLQLNLLLEQQKQLLNESQQKIESQR---MLYDAQLSEE-QGRNLELQ-VLLESEKVRI 3309
Query: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
E ++L+ + + +Q D T +++L++QL
Sbjct: 3310 RE---------MSSTLDRERELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKH 3356
Query: 414 EAVNLLQQQHDQWEEEGKALRQRLQK-LTGERDTLAGQ---TVDLQGEVDSLSKERELLQ 469
+ L + ++++ + RQ+++K R TL + + Q ++ L + E LQ
Sbjct: 3357 SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3416
Query: 470 KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--------- 520
+ EE RQQ+ L+ E RL+ + E Q Q + + +K E + L+ + E
Sbjct: 3417 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3475
Query: 521 RERLQEMLMGLEAKQSES-LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
R R + +E + ES ++LI + + E E++RQ+ V + L Q +E
Sbjct: 3476 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
Query: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
L+ E AD +E + +++ +LQL++
Sbjct: 3536 ------RLQFETAD-----------DEDFIWVQENIDEIILQLQK--------------- 3563
Query: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KL 696
L + +L +T + ++ AEL + + EEK +++ KL
Sbjct: 3564 -------LTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3616
Query: 697 SES-RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
E R ++ + + A EKE REK L+ L+ E + L
Sbjct: 3617 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3676
Query: 756 AEQLQGLSSAKELLESS 772
+L+ S + L S
Sbjct: 3677 KAELRNDSLLQTLSPDS 3693
Score = 51.6 bits (122), Expect = 9e-06
Identities = 128/681 (18%), Positives = 271/681 (39%), Gaps = 130/681 (19%)
Query: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT---LVRKLQAKVLQYRSWCQEL 73
Q +LE + Q QM E Q + E Q++ ++ +V +L++++ Q + EL
Sbjct: 3119 QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKL---EL 3175
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E L+A + +L EL E + + + + +N L +K+ + A
Sbjct: 3176 ETTLKA------------QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223
Query: 134 LREDVEKLTVDWSRARDEL--MRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
L ++ KL R ++EL ++ + Q ++ L + +LL+ ++ + +R
Sbjct: 3224 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
Query: 192 LEMKSATD--RDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL 246
+ + + + R+L + L++E VR+ T + AQ + +G+G+ P++
Sbjct: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
Query: 247 LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI 306
LL +EL+K+ E+ +++L ++ + K L +L T+ Q + +
Sbjct: 3344 LL-----KELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKD------ 3383
Query: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
H + ++ E + Q++ LQ ++D+ + + E+ + +
Sbjct: 3384 ----------RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
Query: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
L+ I +F Q+ ++ +R++ + L Q L + W
Sbjct: 3434 QRLQ---GIMQEFQKQELERE---------EKRESRRILYQNL-----------NEPTTW 3470
Query: 427 EEEGKALRQRL--QKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
R + QK+ GE +++ + +++ G + E E++++ + + +L+VL
Sbjct: 3471 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3530
Query: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543
Q+A S + Q E +E + V+E + E+++ L+ + E
Sbjct: 3531 QKA---------------SERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPS 3573
Query: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
+ + L LLRQ AEL+ + L E DLR +KL
Sbjct: 3574 LVSPSTSCGSLTERLLRQN---------------AELTGHISQLTEEKNDLRNMVMKLEE 3618
Query: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Q+ Q+ R ++ + N A +E +
Sbjct: 3619 -----------------QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT 3661
Query: 664 LEAQLQKAEEAGAELQADLRD 684
L+ L++AE +L+A+LR+
Sbjct: 3662 LQKSLKRAEAEVYKLKAELRN 3682
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 213 bits (541), Expect = 2e-54
Identities = 407/1958 (20%), Positives = 814/1958 (41%), Gaps = 288/1958 (14%)
Query: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329
L ++ + +A L E+ LL + + + EK+ L + ++ +E+ +H A+
Sbjct: 351 LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 410
Query: 330 LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382
+ R + L + K+ + + +E + I Q +G + LEL+ I ++ +Y
Sbjct: 411 IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 469
Query: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434
AL+L + +R + + ++LA + N LQ ++ +
Sbjct: 470 RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 527
Query: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
+ ++LT R+ Q LQ +VD L E EE R Q VL V
Sbjct: 528 LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 580
Query: 495 ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552
E G + G E+ L++++ E + +E + + ++ LR LE
Sbjct: 581 EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 633
Query: 553 -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610
H E +L E + +A++++ + +E +TL+ +++DL+ +L
Sbjct: 634 RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 680
Query: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Q + E +++ C E+ + LQV L E+ THL+ +L+
Sbjct: 681 -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 721
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727
E EL+A L Q E ++ L S +E T +LEQ HQE +
Sbjct: 722 QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 772
Query: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
+ EK L +E E+R + +E+ +++L E + + + +S EAQ Q+ +VT+
Sbjct: 773 LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 827
Query: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
+ E +Q++ + + E++ L+ + E+SQ E E+D ++ A+A++ K L+++
Sbjct: 828 -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 848 KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889
K + Q RE EK H +Q+L + LE L + +EL+
Sbjct: 884 KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 942
Query: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
K + E E + Q A L ++++E ++ER ++ LL + + +
Sbjct: 943 SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1002
Query: 950 RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
R R +M + K+KE + + LQ + + E D +L ++ LL+
Sbjct: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1061
Query: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
+ D+ + QR EQ V+E ++ E +R+Q+ L++ + L +S
Sbjct: 1062 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1105
Query: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
S L + E G E Q E Q+ + K+ + + +
Sbjct: 1106 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1142
Query: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
+L +LE + + L + + Q Q +++ +E+ +E + + +L
Sbjct: 1143 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1196
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
+ S LQ+ L +C S E Q+ + L L A
Sbjct: 1197 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1244
Query: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301
S +K L++D+ + D L+++++ +E R + ++ E+ LQ +L
Sbjct: 1245 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1294
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
++ E+ ET SL+ ++ E E L L ++E LQ
Sbjct: 1295 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1336
Query: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+VV+ LE ++ + L+L N+ +E R +++ E + + L+
Sbjct: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1395
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
N LL + A E+ L G IQ +++ +Q + + L + Q I
Sbjct: 1396 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
Query: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538
ELE ++ L+ L ++ER L Q++ + EK+ E + + + Q+ E+++K +++
Sbjct: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
Query: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592
+ ++Q + ++ E L E++ ++ Q+++ ++ E ++ + A+
Sbjct: 1513 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1570
Query: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650
+ +L+++ EL+ ++ Q+ DLE +T L+++ + ++++ +++ E+ Q++KE
Sbjct: 1571 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1627
Query: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
LE R+QE KE ++ + Q + LE +L ++K+ Q ++Q+
Sbjct: 1628 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1675
Query: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
+ + LE MK + L D ++++ + +L + K+ L ++L K
Sbjct: 1676 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1729
Query: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812
+ ++SLL + Q E + L+ QL ++E+ + E ++Q+ Q+ + L
Sbjct: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
Query: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870
QE EAL+QE Q + K+ A + A + H K + DH
Sbjct: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1844
Query: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
+ EE + + + L+ ++ + +AE + + L+ + Q+H L
Sbjct: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1893
Query: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985
+ +QE +L+ E Q + Q A R ++ +L++ L H +G K+Q L
Sbjct: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
Query: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042
++ + STAT S A Q + R Q ++Q Q L+ + Q LQ+
Sbjct: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2013
Query: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLT 2102
L R E Q ++ L + +R+ E +++K L + +E++ L + + + T
Sbjct: 2014 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQL--CKNT 2069
Query: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK 2140
A + L + Q LE KT+ + L+
Sbjct: 2070 KADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLE 2107
Score = 202 bits (515), Expect = 3e-51
Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
E E LV + + + L + + + + L E++ + KE L S L +A++ S++
Sbjct: 347 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
Query: 790 LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
I+ + + E + + LK EL ER Q Q+ A +Q + EQE + A
Sbjct: 407 HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 463
Query: 845 EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
++ ++ L+E + E E + ++LA+ + + LE L E+ +++
Sbjct: 464 TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 523
Query: 903 AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
A+ +EER L QM+ E E++ L + + + Q EL + Q LR +K
Sbjct: 524 AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 577
Query: 961 KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
+E E G+ + EA+ +++ QH D+ L ++
Sbjct: 578 EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 627
Query: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
+L+ +V + QL D + ++ QE +++ E LE++ + L + E +
Sbjct: 628 ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 681
Query: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124
+ VL+EA E + ++ E+K+L ++E + ++EK L E +L
Sbjct: 682 QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 729
Query: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
L + +AS E++ L++S W +E ++R +LE EQ
Sbjct: 730 RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 769
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
L S +++ E R EL LE Q + E +
Sbjct: 770 --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 804
Query: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301
+ ++ +T Q + QK+ ER ++ + + EL+DLQ Q +EEK
Sbjct: 805 TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 855
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
S+WE +++ L E E E L+ L+R + + ERE+L+ + EHL
Sbjct: 856 SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 906
Query: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
+ VVE + L T +S L + E++S +R L+E+ E+ G + Q
Sbjct: 907 SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 964
Query: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
L + E ++E + + ++ +E + KA E + + + E+ Q +I+E
Sbjct: 965 ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1021
Query: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531
+++ S L L Q E + L++ ++ + LE++ + + + E + E
Sbjct: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
K I + ++Q L+ LV CL E Q + + ++ + V
Sbjct: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1141
Query: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
H+ DLE+ ++ DL S T + + + +E ++ E EL+ +E T+
Sbjct: 1142 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1192
Query: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
E ++Q LQ++ + + D +Q + + + + KL + ER E + + +L+
Sbjct: 1193 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
Query: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
E S+ E ++++ ++ +E +E E+ L+D+L++ +V
Sbjct: 1253 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1301
Query: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810
ET L L + E+ + ++L R QG+++ E SL++ E
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
Query: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865
+ Q +Q LE + E K++ L+G + +AH + HG +Q H+
Sbjct: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1420
Query: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
E+ R + + E + ++ + +L E + ++ L+++ ++ +
Sbjct: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1480
Query: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
V + ++ L+A Q E Q++E LR ES+ + + R L E +
Sbjct: 1481 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1540
Query: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
+ L G ++ + ++ E + A+ + +L + + + L ++ E+ ++
Sbjct: 1541 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1600
Query: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
+ QE +Q+L Q L E+ Q+E+E E QEK NL +E E +++
Sbjct: 1601 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1650
Query: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146
S E +L+ + + I++ ++ LE + H+ + + K+ S+
Sbjct: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1710
Query: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
+L +E E L L E R +++ + A K+ + + QE
Sbjct: 1711 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1770
Query: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
L+ +V + + R++ +L +T++ EKE L + +L + G G+ E
Sbjct: 1771 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1822
Query: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286
P G+ Q R +L+HL +L +++
Sbjct: 1823 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1882
Query: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+ L +H L T+ E+E+ LKRE + + S K + + +Q+
Sbjct: 1883 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Score = 194 bits (493), Expect = 9e-49
Identities = 369/1836 (20%), Positives = 761/1836 (41%), Gaps = 230/1836 (12%)
Query: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
E QE+L L+ SL I L E + LE ELL + + AALA + I L
Sbjct: 320 ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 373
Query: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
+ + E LR+ K L +A + ++ +E N+ +++ E+ +
Sbjct: 374 ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 428
Query: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
+ E K RE + LQ+A + EL+ ++ + E+ I+ +L+ S
Sbjct: 429 RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 478
Query: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753
+ +L + ++ E + + + E ++ EK A ++ + + + R
Sbjct: 479 ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 538
Query: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810
+ Q + L + L+S L E + Q V+ + EV+ + E G C
Sbjct: 539 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
Query: 811 LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L + E EQ ++ R + E LE + +EK++++ +K +
Sbjct: 599 NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 654
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
+Q +LE++ +L+ + E Q + ++ E + E Q+Q++ E+E+
Sbjct: 655 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 714
Query: 930 LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
L E L ++ + L A ER R+ ++ E++ G+ Q Q Q +L
Sbjct: 715 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
Query: 985 RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031
+H +++L L++ L + + ++ + SQ+ A Q D Q++ E+
Sbjct: 775 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
Query: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078
+++L++ QE R +K + E EK LT E ++ L L ++ S+ R
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
+ ++ + E+++L +E LR V E + L+ + + EL++SH E +
Sbjct: 895 EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 950
Query: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184
R + Q + QL +L + + + E ++ N +A +A++++
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
S LQ + + ++ LS + E + +GA SL ++G L + + + S
Sbjct: 1011 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1069
Query: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290
L + H+ K T+ +R L+ ++QKLE L D A + +T Q L
Sbjct: 1070 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
Query: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349
Q+ ++ E ++ + + E+ +L T +S+Q + + E +G EL +
Sbjct: 1128 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
Query: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
+ L Q+ LQ ++ A A ++DL S LK K + +E E +
Sbjct: 1188 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1247
Query: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
+ E + LQE L ++ E E + L ++ L+ + + + E L
Sbjct: 1248 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1306
Query: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510
L+K EV ++ E++ L + + +E L +V +R + L ++ + Q+
Sbjct: 1307 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366
Query: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561
+ ++ + + H + E ++++Q +E ++ +K + ++
Sbjct: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1426
Query: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
LEEN + Q K + + E ++ L LT L+ER L Q D+
Sbjct: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1482
Query: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
SH E+++E+K+ ++ E+Q++ E L + E+ QE + + I L
Sbjct: 1483 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1534
Query: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728
+ E+ + +KL L ++ M ++ E K + A + +E++K
Sbjct: 1535 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
Query: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
L +++++ ++E + ++ +LQEL +L + L ++ G ++ L +REQE
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1637
Query: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
L+++L+ + Q SL+++L E + QE L+ E ++ + Q R + +
Sbjct: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1696
Query: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
D + L LKE+ ++ +L + +E R+ +++ +S
Sbjct: 1697 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1755
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
+ L+A Q++ Q E V+ LQ S +++ L+ QE EAL+ E S Q
Sbjct: 1756 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1809
Query: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017
LQ A GK+ A L + S + + + +L+
Sbjct: 1810 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1861
Query: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071
++ + E+ +E V+QL+ L + ++ + E+E+L K + Q+
Sbjct: 1862 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1917
Query: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
+ + Q E+E+ +H L+ + +++++E++ + PH+
Sbjct: 1918 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1977
Query: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
+++Q+ + E LQ + + LQA + Q E+E R ++T +
Sbjct: 1978 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2028
Query: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
+++ ++ ++E ++ +L+L +R L+++
Sbjct: 2029 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEK 2057
Score = 189 bits (479), Expect = 4e-47
Identities = 398/1916 (20%), Positives = 779/1916 (40%), Gaps = 285/1916 (14%)
Query: 95 NLDELLVRLEEEQQRCES------LAEVNTQLRLHMEKADVV---NKALREDVEKLTVDW 145
NL EL + LE E ++ LA ++R +E+ D V + LR D++K
Sbjct: 338 NLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLK 397
Query: 146 SRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMEL 205
S E+ + + E+ L E+ ++ + + R + ++ R +E
Sbjct: 398 SLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQ 457
Query: 206 KAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAH--ER 263
+ E + + + L L++ SR N +LL K E E + +R
Sbjct: 458 EIEKAKTEENYIRDRLALSLKENSRLEN-----------ELLENAEKLAEYENLTNKLQR 506
Query: 264 SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
+ E + + GDL+ + + + E LTQ + + YE+ + L++ V+ L++ EL
Sbjct: 507 NLENVLAEKFGDLDPSSAEFFLQE--ERLTQMRNE---YERQCRVLQDQVDELQS---EL 558
Query: 324 MEHEASLSRNAQEEKLSLQQVIKDITQVMVEE---GDNIAQGSGHENSLELDSSI----- 375
E+ A + L+ +K+ VE G G G E L+ SI
Sbjct: 559 EEYRA--------QGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELV 610
Query: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435
Q Q L + + R + L + + C++A ++Q+H E E L +
Sbjct: 611 IEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH---ENETHTLEK 667
Query: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV-LEQEAWRLR---R 491
++ L E +LQG+ L + EE ++QL+V LE+E L+ R
Sbjct: 668 QISDLKNE-------IAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
Query: 492 VNVELQLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
+ E++L+ Q Q E ++E L + E+++ + LE E L+ L+ + L
Sbjct: 721 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVE-KHTL 779
Query: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609
E L ELL + Q E+ + E +S A ++ K++ E+
Sbjct: 780 EKEELRKELLEKHQRELQEGREKMETECNRRTSQIE------AQFQSDCQKVTERCESAL 833
Query: 610 LDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR-REALWEKNTHLEAQ 667
G Q+L L+E+ + S+ E ++ L + AEA++ +E L + T
Sbjct: 834 QSLEGRYRQELKDLQEQQREEKSQWEFE---KDELTQECAEAQELLKETLKREKTTSLVL 890
Query: 668 LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH----QQEAATTQLEQLHQEAKRQ--- 720
Q+ E + L + E++++ + L + R+ QQ + Q+ +L KR+
Sbjct: 891 TQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELRE 950
Query: 721 -EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA-KELLESSLFEAQQ 778
EEVL +A ++ + LE+ +++RQ++ +L + + K E++ E +
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEH---DQERQEMMSKLLAMENIHKATCETADRERAE 1007
Query: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
++ I + +++ ++Q T ++Q + + + E E D A L Q EQ
Sbjct: 1008 MSTEISRLQSKIK-EMQQATSPLSMLQSGCQVI--------GEEEVEGDGALSLLQQGEQ 1058
Query: 839 ---EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895
E L + AHE+ V + K E S QQ L K L L E
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKE-NVKMATEISRLQQRLQKLEPGLVMSSC-----LDEPA 1112
Query: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
TE A++ E Q ++ Q++ T + +S D+
Sbjct: 1113 TEFFGNTAEQTEPFLQ-QNRTKQVEGVTRRHVLS------------------------DL 1147
Query: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
+ ++++ +TG Q QE + E EA+ + +L E S + +L+ Q+ L
Sbjct: 1148 EDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSEL----ENSEETRTESWELKNQISQL 1203
Query: 1016 KSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-EKASLTLSLMEKEQRLLVLQEA 1074
+ QL+ ++ Q+ L + + K LER +AS L+ ++ V +E
Sbjct: 1204 QEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYED----VSREN 1259
Query: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEA---DFLAQEAQLLEELEAS 1131
D + Q+EL + EA KEL+A++ L+ E+K+ E FL+ E + +
Sbjct: 1260 DCL-QEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLE----KSYDEV 1314
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRST------ESQLEALAAEQQPGNQAQAQAQLASL 1185
I ++L + + K +LQ + E+ LE L E GN Q L
Sbjct: 1315 KIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPD-GNILQLNQTLEEC 1373
Query: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245
++ + E + E + + G T L + A +
Sbjct: 1374 VPRVRSVHHVIEECKQE----------------------NQYLEGN--TQLLEKVKAHEI 1409
Query: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLT------------DTEAEKSQVHTELQDLQRQ 1293
LH + +T Q R +++QV LEE T T AE T+LQ+L R+
Sbjct: 1410 AWLHGTI-QTHQERPRVQNQVI-LEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRK 1467
Query: 1294 LSQN------QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
L + Q++ K+ L++ + +L T + +Q ++ + + Q E +L+
Sbjct: 1468 LKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILR 1527
Query: 1348 AAKENLTAQ--------------VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
L + E + + + +A + E+L+ S LK+KN+
Sbjct: 1528 NEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQ 1587
Query: 1394 EVESERERAQALQEQGELKVAQ-GKALQENLALLTQ-----TLAEREEEVETLRGQIQEL 1447
+++ E Q + K+ + + L E L + L ERE+E L+ +++
Sbjct: 1588 QLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERC 1647
Query: 1448 EKQREMQKAALELLSLDLK-------KRNQEVDLQQEQIQELEKCRSV--LEHLPMAVQE 1498
+ Q ++LE ++K + N + + E++++L +C + + +V
Sbjct: 1648 KVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLS 1707
Query: 1499 REQKLTVQREQIRELEK---DRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555
+KL ++E + E D+ + ++LEH++ ++++ + E Q LK QLV
Sbjct: 1708 YNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSAS---LKSQLVAS 1764
Query: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ---------ELQA 1606
+ LE+ + Q +K + ++ AL + L ++ Q E+
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIAT 1824
Query: 1607 QSSQIHD--------------------LESHSTVLARELQERDQEVKSQREQIEELQ--- 1643
S +H+ L + L +Q E+ RE++ +L+
Sbjct: 1825 HPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884
Query: 1644 --RQKEHLTQD--LERRDQE-LMLQKERIQVLEDQRTRQTKI-----LEEDLEQIKLS-- 1691
+ ++HL + +QE L L++E Q ++Q K+ LE++LE I L
Sbjct: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENE 1944
Query: 1692 -LRERGRELTTQRQLMQE---RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE 1747
L+++ +L Q MQ A P L+ + +E+ ++ Q++ + +
Sbjct: 1945 GLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLL-Q 2003
Query: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807
+ + L+++L+ + ET+ +EQ + V+++++ E ++ +L ++ LQ ++++
Sbjct: 2004 AERINQHLQEELEN---RTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ 2060
Query: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQD 1863
+ L ++ + +A+ ++ Q + E + Q E+ + L+E+ L +
Sbjct: 2061 LKEQLC-KNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSN 2115
Score = 179 bits (455), Expect = 2e-44
Identities = 344/1666 (20%), Positives = 682/1666 (40%), Gaps = 251/1666 (15%)
Query: 855 VNQLREKWEKERSWHQQELAKALE-SLERE--------KMELEMRLKEQQTEMEAIQAQR 905
V ++ + W++E + QE+ KAL+ SL+ +E E+ + + A+ + +
Sbjct: 307 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
Query: 906 EEERTQAESALCQMQLETEKERVSL-----LETLLQTQKELADASQQLERLRQDMKVQKL 960
E R E + Q+ E EK R L L++L+ + E+ D +ER R + ++KL
Sbjct: 367 AEIRHLLE-RVDQVVREKEKLRSDLDKAEKLKSLMAS--EVDDHHAAIER-RNEYNLRKL 422
Query: 961 KEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEES---SSLLQDKMDLQ-KQVED 1014
E+ E L+ +L++ + ++ + A + R +L E++ + ++D++ L K+
Sbjct: 423 DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
Query: 1015 LKSQLVAQDDSQRLVEQE-VQEKLRETQEYNRIQK---------ELEREKASLTLSLMEK 1064
L+++L+ +++++L E E + KL+ E +K E ++ LT E
Sbjct: 483 LENELL--ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
Query: 1065 EQRLLVLQEADSIRQQELS-------ALRQDMQEAQGEQKE------------------- 1098
E++ VLQ+ Q EL LR ++ + E+ E
Sbjct: 541 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
Query: 1099 --LSAQMELLRQEVKEKE-----------ADFLAQEAQLLEELEAS-------------- 1131
+S + EL+ +++KE+ D + + L+E S
Sbjct: 601 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 1132 --HITEQQLR------ASLWAQEA--KAAQLQLRLRSTE--SQLEALAAEQQPGNQAQAQ 1179
H E+Q+ A L Q A K A + R E QL+ E++ Q + +
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
Query: 1180 AQ-LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD-----QNGARSLFKRGPLL 1233
Q L + L QA S R L + V GL + Q SL ++
Sbjct: 721 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK---- 776
Query: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL-----TDTEAEKSQVHTELQ 1288
L E + L + HQ + Q+ R+ + + + ++ +D + + + LQ
Sbjct: 777 HTLEKEELRKELLEKHQR--ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
Query: 1289 DLQRQL--------SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
L+ + Q +EEKS+WE +++ L E E E L+ L+R + +
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLT 891
Query: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
ERE+L+ + EHL + VVE + L T +S L + E++S +
Sbjct: 892 QEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 945
Query: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460
R L+E+ E+ G + Q L + E ++E + + ++ +E + KA E
Sbjct: 946 R--ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATCET 1000
Query: 1461 LSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ---EREQK------LTVQREQIR 1511
+ + + E+ Q +I+E+++ S L L Q E E + L Q EQ+
Sbjct: 1001 ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLL 1060
Query: 1512 ELEKD-RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
E D + + E + E K I + ++Q L+ LV CL E
Sbjct: 1061 EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
Query: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Q + + ++ + V H+ DLE+ ++ DL S T + + + +
Sbjct: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLED---------DEVRDLGSTGTSSVQRQEVKIE 1171
Query: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED----QRTRQTKILEEDLE 1686
E ++ E EL+ +E T+ E ++Q LQ++ + + D +Q + + +
Sbjct: 1172 ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVL 1231
Query: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
+ KL + ER E + + +L+ E S+ E ++++ ++ +E +E
Sbjct: 1232 KKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETRYDEALENNKELTA 1285
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ--EAREQGELK------- 1797
E+ L+D+L++ +V ET L L + E+ + ++L R QG+++
Sbjct: 1286 EVFRLQDELKKM-----EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVV 1340
Query: 1798 --------EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE- 1848
E SL++ E + Q +Q LE + E K++ L+G +
Sbjct: 1341 QRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL 1400
Query: 1849 ----QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE-------VLGDLRAESR 1897
+AH + HG +Q H+E+ R + + E + ++ + +L E
Sbjct: 1401 LEKVKAH-EIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT 1459
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQA-----QAVLKERDQELEALRAESQSS 1952
+ ++ L+++ ++ +V + ++ L+A Q E Q++E LR ES+
Sbjct: 1460 KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1519
Query: 1953 RHQEEAARARAEALQEALGKAH---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
+ + R L E ++ L G ++ + ++ E + A+ + +L
Sbjct: 1520 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
Query: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
+ + + L ++ E+ ++ + QE +Q+L Q L E+ Q+E+E
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT----EMLCQKEKEP------GNSA 1629
Query: 2070 QENMIQEKQNLGQEREEEEIR-GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
E QEK NL +E E +++ S E +L+ + + I++ ++ LE +
Sbjct: 1630 LEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1689
Query: 2129 HKTSPMEEQSLKLDSL---EPRLQRELERLQAALRQ----------TEAREIEWREKAQD 2175
H+ + + K+ S+ +L +E E L L E R +++ +
Sbjct: 1690 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1749
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
A K+ + + QE L+ +V + + R++ +L +T++ EKE L +
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1807
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ----SWRQRLEHLQQAVARLEIDRSRLQR 2291
+L + G G+ E P G+ Q SW +L+HL +L + +R
Sbjct: 1808 KQLQNAG------GKSWAPEIATHPSGLHNQQKRLSW-DKLDHLMNEEQQLLWQEN--ER 1858
Query: 2292 HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+++T ++ R K+++ ++ + +PT+Q+
Sbjct: 1859 LQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
Score = 134 bits (338), Expect = 8e-31
Identities = 287/1449 (19%), Positives = 569/1449 (39%), Gaps = 191/1449 (13%)
Query: 8 LNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67
L + L ++E+ L ++ E R+L+ +E + + R+ Q++
Sbjct: 762 LEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECN--RRTSQIEAQFQ 819
Query: 68 SWCQELEKR----LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLH 123
S CQ++ +R L++ G Q ++++E +E E+ + + AE L+
Sbjct: 820 SDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKET 879
Query: 124 MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183
+++ + L ++ E L + + ++ + Q + E + + + L
Sbjct: 880 LKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSD---- 935
Query: 184 VVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREP 243
LE+KS+ R+L E + + S RL + M +
Sbjct: 936 ------QILELKSSHKRELREREEVLCQAGASEQLASQRLE-RLEMEHDQERQEMMSKLL 988
Query: 244 AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY- 302
A + A + ++E E S E+ +L+S+ E+Q + LS L + Q E+
Sbjct: 989 AMENIHKATCETADRERAEMSTEISRLQSK----IKEMQQATSPLSMLQSGCQVIGEEEV 1044
Query: 303 --EKMIKALRETVEILETNHTELME----HEASLSRNAQ--EEKLSLQQVIKDITQVMV- 353
+ + L++ ++LE N L+ HE ++ N + E LQQ ++ + +V
Sbjct: 1045 EGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVM 1104
Query: 354 -----EEGDNIAQGSGHENSLELDSS------------IFSQFDYQDADKALTLVRSVLT 396
E + + L + + S + + + S +
Sbjct: 1105 SSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQ 1164
Query: 397 RRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA--LRQRLQKLTGERDTLAGQTVDL 454
R+ +++ + G E N + + + WE + + L+++L L + D + + DL
Sbjct: 1165 RQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDL 1224
Query: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
+V L K+ ++L++ E + + E +
Sbjct: 1225 LFDVSVLKKKLKMLERIPEASPKYKLLYEDVS---------------------------- 1256
Query: 515 HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAE 574
RE + LQE L +E + E+L L E L+ EL + E EVT E
Sbjct: 1257 ----RENDCLQEELRMMETRYDEALENNKEL--TAEVFRLQDELKKME--EVTETFLSLE 1308
Query: 575 QSIAELSSSENTLKTEVADLRAAAVKLS-------------ALNEALALDKVG----LNQ 617
+S E+ L V L+ KL A E L ++ G LNQ
Sbjct: 1309 KSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQ 1368
Query: 618 QLLQLEEENQSVCSRMEAAEQARNALQ--VDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675
L + +SV +E +Q L+ L E K E W T Q + +
Sbjct: 1369 TLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQ 1428
Query: 676 AELQAD--LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733
L+ + L Q++ + Q ++E E T+L++L ++ K + +L V++K+
Sbjct: 1429 VILEENTTLLGFQDKHFQHQATIAEL----ELEKTKLQELTRKLKERVTIL---VKQKDV 1481
Query: 734 LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
L + E L+A+ D Q ++Q ELL + QQ+NS+ L +
Sbjct: 1482 LSHGEK--EEELKAMMHDLQITCSEMQ---QKVELLRYESEKLQQENSI-------LRNE 1529
Query: 794 IQTVTQAKEVIQGEVRCLKLELDT--ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851
I T+ + + ++ L + ++++ ++ +AA +++ + ++ + L+ +
Sbjct: 1530 ITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQL 1589
Query: 852 EKEVNQLREKWEKERSWHQQELAKALESL-EREKMELEMRLKEQQTEMEAIQAQREEERT 910
+ E +L +K + + Q+ + E L ++EK L+E+ E E + E ER
Sbjct: 1590 DLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER--EQEKFNLKEELERC 1647
Query: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE--QETTGI 968
+ +S+ LE E V + ++Q + L +LE+++Q + L + Q+ + +
Sbjct: 1648 KVQSSTLVSSLEAELSEVKIQTHIVQQENHLL--KDELEKMKQLHRCPDLSDFQQKISSV 1705
Query: 969 LQ--TQLQEAQRELKEAARQHRDDLAA---LQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
L +L + + L E D LA L+ +++ Q++ + Q LKSQLVA
Sbjct: 1706 LSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQ 1765
Query: 1024 DSQRLVEQEVQE------KLRETQEYNRIQKE-LEREKASLTLSL--------------- 1061
+ + +E VQ +++ + +KE L++E SL L
Sbjct: 1766 EKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATH 1825
Query: 1062 ---MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFL 1118
+ +Q+ L + D + +E L Q+ + Q + A++ R++V++ E++ L
Sbjct: 1826 PSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLL 1885
Query: 1119 AQEAQLLEELEASHITEQQLRA------SLWAQEAKAAQLQLRLRSTESQLEALAAEQQ- 1171
+ + L + TEQ+ + +++ A + ++ S E +LE + E +
Sbjct: 1886 PKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEG 1945
Query: 1172 -PGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRG 1230
Q + QL + Q L S P +P W L+ Q A + R
Sbjct: 1946 LKKKQVKLDEQLMEM-----QHLRSTATPSP--------SPHAWDLQLLQQQACPMVPRE 1992
Query: 1231 PLLTA----LSAEAVASALHKLHQDLWKTQQTRDVLRDQ-VQKLEERLTDTEAEKSQVHT 1285
L L AE + L + ++ T ++Q V +EER+ + E + V
Sbjct: 1993 QFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKR 2052
Query: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
LQ+ QL + + +K + L E +L + + + R + AE + + +
Sbjct: 2053 LLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIAS 2112
Query: 1346 LQAAKENLT 1354
L NLT
Sbjct: 2113 LSNIVRNLT 2121
Score = 92.0 bits (227), Expect = 6e-18
Identities = 170/744 (22%), Positives = 304/744 (40%), Gaps = 127/744 (17%)
Query: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
L+ ++ +L+L L T+ + Q K R LE + ++R+KEK
Sbjct: 333 LDGNINLTELTLALENELLVTKNSIHQAALASFKAEI---RHLLERVDQVVREKEK---- 385
Query: 1741 QQEHIHELQELKDQLEQQLQGLHRKV---GETSL--LLSQREQEIVVLQQQLQEAREQGE 1795
+ + + ++LK + ++ H + E +L L + ++ I L+ +L++ REQ
Sbjct: 386 LRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ-- 443
Query: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
L Q ++ L+QE ++A+ +E ++++ + L
Sbjct: 444 ---------------ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
Query: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
E +L +++ +L+ L L E GDL S E +++ +
Sbjct: 489 ENAEKLAEYENLTNKLQRNLE------NVLAEKFGDLDPSSAE----FFLQEERLTQMRN 538
Query: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH- 1974
E+E + R LQD + Q+ L+E + LR ++S +E A + + LG
Sbjct: 539 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
Query: 1975 -----------AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Q KEQH + L LE + LD ++ +E ++ +
Sbjct: 599 NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH 658
Query: 2024 G------EIQDQDLRYQEDVQQLQQAL---AQRDEELRHQQEREQLL-----EKSLAQ-- 2067
E Q DL+ + Q Q A+ A + RH++E++QL EK+ Q
Sbjct: 659 ENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEK 718
Query: 2068 -RVQENM------IQEKQNLGQERE--------EEEIRGLHQSVREL---QLT------L 2103
R+Q M Q + + +ERE EE++RGL Q + + QLT
Sbjct: 719 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 778
Query: 2104 AQKEQEILELRETQQRNNLEALPH-----SHKTSPMEEQ------------SLKLDSLEP 2146
+KE+ EL E QR E + +TS +E Q L SLE
Sbjct: 779 LEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
Query: 2147 RLQRELERLQAALRQTEAR-EIEWREKAQDLALSLAQTKASVSSLQEVAMFL--QASVLE 2203
R ++EL+ LQ R+ +++ E E E Q+ A + K ++ + ++ L + +LE
Sbjct: 839 RYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE 898
Query: 2204 RD---------SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254
+ E+Q+L +LE R E ++ S + EL S ++ ++ E
Sbjct: 899 KTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ--SLLSDQILELKSSHKRELREREEVLC 956
Query: 2255 EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
+A S ++ R +EH Q+ R E+ L N+ ++T E +RER ++ E
Sbjct: 957 QAGASEQLASQRLERLEMEHDQE---RQEMMSKLLAMENIH-KATCETADRERAEMSTEI 1012
Query: 2315 MRAAQAGSLEISKATASSPTQQDG 2338
R Q+ E+ +AT+ Q G
Sbjct: 1013 SR-LQSKIKEMQQATSPLSMLQSG 1035
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 212 bits (540), Expect = 3e-54
Identities = 399/1914 (20%), Positives = 799/1914 (41%), Gaps = 286/1914 (14%)
Query: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329
L ++ + +A L E+ LL + + + EK+ L + ++ +E+ +H A+
Sbjct: 357 LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 416
Query: 330 LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382
+ R + L + K+ + + +E + I Q +G + LEL+ I ++ +Y
Sbjct: 417 IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 475
Query: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434
AL+L + +R + + ++LA + N LQ ++ +
Sbjct: 476 RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 533
Query: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
+ ++LT R+ Q LQ +VD L E EE R Q VL V
Sbjct: 534 LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 586
Query: 495 ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552
E G + G E+ L++++ E + +E + + ++ LR LE
Sbjct: 587 EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 639
Query: 553 -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610
H E +L E + +A++++ + +E +TL+ +++DL+ +L
Sbjct: 640 RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 686
Query: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Q + E +++ C E+ + LQV L E+ THL+ +L+
Sbjct: 687 -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 727
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727
E EL+A L Q E ++ L S +E T +LEQ HQE +
Sbjct: 728 QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 778
Query: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
+ EK L +E E+R + +E+ +++L E + + + +S EAQ Q+ +VT+
Sbjct: 779 LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 833
Query: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
+ E +Q++ + + E++ L+ + E+SQ E E+D ++ A+A++ K L+++
Sbjct: 834 -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 889
Query: 848 KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889
K + Q RE EK H +Q+L + LE L + +EL+
Sbjct: 890 KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 948
Query: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
K + E E + Q A L ++++E ++ER ++ LL + + +
Sbjct: 949 SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1008
Query: 950 RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
R R +M + K+KE + + LQ + + E D +L ++ LL+
Sbjct: 1009 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1067
Query: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
+ D+ + QR EQ V+E ++ E +R+Q+ L++ + L +S
Sbjct: 1068 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1111
Query: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
S L + E G E Q E Q+ + K+ + + +
Sbjct: 1112 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1148
Query: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
+L +LE + + L + + Q Q +++ +E+ +E + + +L
Sbjct: 1149 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1202
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
+ S LQ+ L +C S E Q+ + L L A
Sbjct: 1203 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1250
Query: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301
S +K L++D+ + D L+++++ +E R + ++ E+ LQ +L
Sbjct: 1251 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1300
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
++ E+ ET SL+ ++ E E L L ++E LQ
Sbjct: 1301 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1342
Query: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+VV+ LE ++ + L+L N+ +E R +++ E + + L+
Sbjct: 1343 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1401
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
N LL + A E+ L G IQ +++ +Q + + L + Q I
Sbjct: 1402 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1458
Query: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538
ELE ++ L+ L ++ER L Q++ + EK+ E + + + Q+ E+++K +++
Sbjct: 1459 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1518
Query: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592
+ ++Q + ++ E L E++ ++ Q+++ ++ E ++ + A+
Sbjct: 1519 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1576
Query: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650
+ +L+++ EL+ ++ Q+ DLE +T L+++ + ++++ +++ E+ Q++KE
Sbjct: 1577 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1633
Query: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
LE R+QE KE ++ + Q + LE +L ++K+ Q ++Q+
Sbjct: 1634 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1681
Query: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
+ + LE MK + L D ++++ + +L + K+ L ++L K
Sbjct: 1682 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1735
Query: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812
+ ++SLL + Q E + L+ QL ++E+ + E ++Q+ Q+ + L
Sbjct: 1736 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1795
Query: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870
QE EAL+QE Q + K+ A + A + H K + DH
Sbjct: 1796 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1850
Query: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
+ EE + + + L+ ++ + +AE + + L+ + Q+H L
Sbjct: 1851 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1899
Query: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985
+ +QE +L+ E Q + Q A R ++ +L++ L H +G K+Q L
Sbjct: 1900 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1959
Query: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042
++ + STAT S A Q + R Q ++Q Q L+ + Q LQ+
Sbjct: 1960 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2019
Query: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096
L R E Q ++ L + +R+ E +++K L + +E++ L + V
Sbjct: 2020 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQV 2071
Score = 202 bits (515), Expect = 3e-51
Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
E E LV + + + L + + + + L E++ + KE L S L +A++ S++
Sbjct: 353 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 412
Query: 790 LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
I+ + + E + + LK EL ER Q Q+ A +Q + EQE + A
Sbjct: 413 HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 469
Query: 845 EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
++ ++ L+E + E E + ++LA+ + + LE L E+ +++
Sbjct: 470 TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 529
Query: 903 AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
A+ +EER L QM+ E E++ L + + + Q EL + Q LR +K
Sbjct: 530 AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 583
Query: 961 KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
+E E G+ + EA+ +++ QH D+ L ++
Sbjct: 584 EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 633
Query: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
+L+ +V + QL D + ++ QE +++ E LE++ + L + E +
Sbjct: 634 ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 687
Query: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124
+ VL+EA E + ++ E+K+L ++E + ++EK L E +L
Sbjct: 688 QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 735
Query: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
L + +AS E++ L++S W +E ++R +LE EQ
Sbjct: 736 RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 775
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
L S +++ E R EL LE Q + E +
Sbjct: 776 --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 810
Query: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301
+ ++ +T Q + QK+ ER ++ + + EL+DLQ Q +EEK
Sbjct: 811 TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 861
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
S+WE +++ L E E E L+ L+R + + ERE+L+ + EHL
Sbjct: 862 SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 912
Query: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
+ VVE + L T +S L + E++S +R L+E+ E+ G + Q
Sbjct: 913 SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 970
Query: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
L + E ++E + + ++ +E + KA E + + + E+ Q +I+E
Sbjct: 971 ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1027
Query: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531
+++ S L L Q E + L++ ++ + LE++ + + + E + E
Sbjct: 1028 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1087
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
K I + ++Q L+ LV CL E Q + + ++ + V
Sbjct: 1088 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1147
Query: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
H+ DLE+ ++ DL S T + + + +E ++ E EL+ +E T+
Sbjct: 1148 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1198
Query: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
E ++Q LQ++ + + D +Q + + + + KL + ER E + + +L+
Sbjct: 1199 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1258
Query: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
E S+ E ++++ ++ +E +E E+ L+D+L++ +V
Sbjct: 1259 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1307
Query: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810
ET L L + E+ + ++L R QG+++ E SL++ E
Sbjct: 1308 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1367
Query: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865
+ Q +Q LE + E K++ L+G + +AH + HG +Q H+
Sbjct: 1368 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1426
Query: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
E+ R + + E + ++ + +L E + ++ L+++ ++ +
Sbjct: 1427 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1486
Query: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
V + ++ L+A Q E Q++E LR ES+ + + R L E +
Sbjct: 1487 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1546
Query: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
+ L G ++ + ++ E + A+ + +L + + + L ++ E+ ++
Sbjct: 1547 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1606
Query: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
+ QE +Q+L Q L E+ Q+E+E E QEK NL +E E +++
Sbjct: 1607 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1656
Query: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146
S E +L+ + + I++ ++ LE + H+ + + K+ S+
Sbjct: 1657 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1716
Query: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
+L +E E L L E R +++ + A K+ + + QE
Sbjct: 1717 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1776
Query: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
L+ +V + + R++ +L +T++ EKE L + +L + G G+ E
Sbjct: 1777 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1828
Query: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286
P G+ Q R +L+HL +L +++
Sbjct: 1829 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1888
Query: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+ L +H L T+ E+E+ LKRE + + S K + + +Q+
Sbjct: 1889 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1941
Score = 195 bits (496), Expect = 4e-49
Identities = 373/1848 (20%), Positives = 765/1848 (41%), Gaps = 236/1848 (12%)
Query: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
E QE+L L+ SL I L E + LE ELL + + AALA + I L
Sbjct: 326 ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 379
Query: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
+ + E LR+ K L +A + ++ +E N+ +++ E+ +
Sbjct: 380 ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 434
Query: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
+ E K RE + LQ+A + EL+ ++ + E+ I+ +L+ S
Sbjct: 435 RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 484
Query: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753
+ +L + ++ E + + + E ++ EK A ++ + + + R
Sbjct: 485 ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 544
Query: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810
+ Q + L + L+S L E + Q V+ + EV+ + E G C
Sbjct: 545 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
Query: 811 LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L + E EQ ++ R + E LE + +EK++++ +K +
Sbjct: 605 NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 660
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
+Q +LE++ +L+ + E Q + ++ E + E Q+Q++ E+E+
Sbjct: 661 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 720
Query: 930 LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
L E L ++ + L A ER R+ ++ E++ G+ Q Q Q +L
Sbjct: 721 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 780
Query: 985 RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031
+H +++L L++ L + + ++ + SQ+ A Q D Q++ E+
Sbjct: 781 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
Query: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078
+++L++ QE R +K + E EK LT E ++ L L ++ S+ R
Sbjct: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 900
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
+ ++ + E+++L +E LR V E + L+ + + EL++SH E +
Sbjct: 901 EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 956
Query: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184
R + Q + QL +L + + + E ++ N +A +A++++
Sbjct: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1016
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
S LQ + + ++ LS + E + +GA SL ++G L + + + S
Sbjct: 1017 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1075
Query: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290
L + H+ K T+ +R L+ ++QKLE L D A + +T Q L
Sbjct: 1076 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1133
Query: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349
Q+ ++ E ++ + + E+ +L T +S+Q + + E +G EL +
Sbjct: 1134 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1193
Query: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
+ L Q+ LQ ++ A A ++DL S LK K + +E E +
Sbjct: 1194 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1253
Query: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
+ E + LQE L ++ E E + L ++ L+ + + + E L
Sbjct: 1254 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1312
Query: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510
L+K EV ++ E++ L + + +E L +V +R + L ++ + Q+
Sbjct: 1313 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1372
Query: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561
+ ++ + + H + E ++++Q +E ++ +K + ++
Sbjct: 1373 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1432
Query: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
LEEN + Q K + + E ++ L LT L+ER L Q D+
Sbjct: 1433 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1488
Query: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
SH E+++E+K+ ++ E+Q++ E L + E+ QE + + I L
Sbjct: 1489 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1540
Query: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728
+ E+ + +KL L ++ M ++ E K + A + +E++K
Sbjct: 1541 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
Query: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
L +++++ ++E + ++ +LQEL +L + L ++ G ++ L +REQE
Sbjct: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1643
Query: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
L+++L+ + Q SL+++L E + QE L+ E ++ + Q R + +
Sbjct: 1644 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1702
Query: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
D + L LKE+ ++ +L + +E R+ +++ +S
Sbjct: 1703 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1761
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
+ L+A Q++ Q E V+ LQ S +++ L+ QE EAL+ E S Q
Sbjct: 1762 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1815
Query: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017
LQ A GK+ A L + S + + + +L+
Sbjct: 1816 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1867
Query: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071
++ + E+ +E V+QL+ L + ++ + E+E+L K + Q+
Sbjct: 1868 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1923
Query: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
+ + Q E+E+ +H L+ + +++++E++ + PH+
Sbjct: 1924 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1983
Query: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
+++Q+ + E LQ + + LQA + Q E+E R ++T +
Sbjct: 1984 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2034
Query: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALE------KERLHSPG 2231
+++ ++ ++E ++ +L+L +R L+ KE++ PG
Sbjct: 2035 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEKVNQLKEQVSLPG 2075
Score = 179 bits (455), Expect = 2e-44
Identities = 344/1666 (20%), Positives = 682/1666 (40%), Gaps = 251/1666 (15%)
Query: 855 VNQLREKWEKERSWHQQELAKALE-SLERE--------KMELEMRLKEQQTEMEAIQAQR 905
V ++ + W++E + QE+ KAL+ SL+ +E E+ + + A+ + +
Sbjct: 313 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 372
Query: 906 EEERTQAESALCQMQLETEKERVSL-----LETLLQTQKELADASQQLERLRQDMKVQKL 960
E R E + Q+ E EK R L L++L+ + E+ D +ER R + ++KL
Sbjct: 373 AEIRHLLE-RVDQVVREKEKLRSDLDKAEKLKSLMAS--EVDDHHAAIER-RNEYNLRKL 428
Query: 961 KEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEES---SSLLQDKMDLQ-KQVED 1014
E+ E L+ +L++ + ++ + A + R +L E++ + ++D++ L K+
Sbjct: 429 DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 488
Query: 1015 LKSQLVAQDDSQRLVEQE-VQEKLRETQEYNRIQK---------ELEREKASLTLSLMEK 1064
L+++L+ +++++L E E + KL+ E +K E ++ LT E
Sbjct: 489 LENELL--ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 546
Query: 1065 EQRLLVLQEADSIRQQELS-------ALRQDMQEAQGEQKE------------------- 1098
E++ VLQ+ Q EL LR ++ + E+ E
Sbjct: 547 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 606
Query: 1099 --LSAQMELLRQEVKEKE-----------ADFLAQEAQLLEELEAS-------------- 1131
+S + EL+ +++KE+ D + + L+E S
Sbjct: 607 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 666
Query: 1132 --HITEQQLR------ASLWAQEA--KAAQLQLRLRSTE--SQLEALAAEQQPGNQAQAQ 1179
H E+Q+ A L Q A K A + R E QL+ E++ Q + +
Sbjct: 667 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 726
Query: 1180 AQ-LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD-----QNGARSLFKRGPLL 1233
Q L + L QA S R L + V GL + Q SL ++
Sbjct: 727 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK---- 782
Query: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL-----TDTEAEKSQVHTELQ 1288
L E + L + HQ + Q+ R+ + + + ++ +D + + + LQ
Sbjct: 783 HTLEKEELRKELLEKHQR--ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 840
Query: 1289 DLQRQL--------SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
L+ + Q +EEKS+WE +++ L E E E L+ L+R + +
Sbjct: 841 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLT 897
Query: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
ERE+L+ + EHL + VVE + L T +S L + E++S +
Sbjct: 898 QEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 951
Query: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460
R L+E+ E+ G + Q L + E ++E + + ++ +E + KA E
Sbjct: 952 R--ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATCET 1006
Query: 1461 LSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ---EREQK------LTVQREQIR 1511
+ + + E+ Q +I+E+++ S L L Q E E + L Q EQ+
Sbjct: 1007 ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLL 1066
Query: 1512 ELEKD-RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
E D + + E + E K I + ++Q L+ LV CL E
Sbjct: 1067 EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1126
Query: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Q + + ++ + V H+ DLE+ ++ DL S T + + + +
Sbjct: 1127 EQTEPFLQQNRTKQVEGVTRRHVLSDLED---------DEVRDLGSTGTSSVQRQEVKIE 1177
Query: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED----QRTRQTKILEEDLE 1686
E ++ E EL+ +E T+ E ++Q LQ++ + + D +Q + + +
Sbjct: 1178 ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVL 1237
Query: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
+ KL + ER E + + +L+ E S+ E ++++ ++ +E +E
Sbjct: 1238 KKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETRYDEALENNKELTA 1291
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ--EAREQGELK------- 1797
E+ L+D+L++ +V ET L L + E+ + ++L R QG+++
Sbjct: 1292 EVFRLQDELKKM-----EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVV 1346
Query: 1798 --------EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE- 1848
E SL++ E + Q +Q LE + E K++ L+G +
Sbjct: 1347 QRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL 1406
Query: 1849 ----QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE-------VLGDLRAESR 1897
+AH + HG +Q H+E+ R + + E + ++ + +L E
Sbjct: 1407 LEKVKAH-EIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT 1465
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQA-----QAVLKERDQELEALRAESQSS 1952
+ ++ L+++ ++ +V + ++ L+A Q E Q++E LR ES+
Sbjct: 1466 KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1525
Query: 1953 RHQEEAARARAEALQEALGKAH---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
+ + R L E ++ L G ++ + ++ E + A+ + +L
Sbjct: 1526 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1585
Query: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
+ + + L ++ E+ ++ + QE +Q+L Q L E+ Q+E+E
Sbjct: 1586 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT----EMLCQKEKEP------GNSA 1635
Query: 2070 QENMIQEKQNLGQEREEEEIR-GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
E QEK NL +E E +++ S E +L+ + + I++ ++ LE +
Sbjct: 1636 LEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1695
Query: 2129 HKTSPMEEQSLKLDSL---EPRLQRELERLQAALRQ----------TEAREIEWREKAQD 2175
H+ + + K+ S+ +L +E E L L E R +++ +
Sbjct: 1696 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1755
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
A K+ + + QE L+ +V + + R++ +L +T++ EKE L +
Sbjct: 1756 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1813
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ----SWRQRLEHLQQAVARLEIDRSRLQR 2291
+L + G G+ E P G+ Q SW +L+HL +L + +R
Sbjct: 1814 KQLQNAG------GKSWAPEIATHPSGLHNQQKRLSW-DKLDHLMNEEQQLLWQEN--ER 1864
Query: 2292 HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+++T ++ R K+++ ++ + +PT+Q+
Sbjct: 1865 LQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1910
Score = 144 bits (362), Expect = 1e-33
Identities = 326/1556 (20%), Positives = 623/1556 (40%), Gaps = 237/1556 (15%)
Query: 16 LQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEK 75
L+L LE++V ++Q+ E + + +N + QR L+ ++ ++ EL+
Sbjct: 631 LRLELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAELQG 687
Query: 76 RLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALR 135
+ + EE +L V+LEEE+ + +LRL E L+
Sbjct: 688 QAAVLKEAHHEATCRHEEEK-KQLQVKLEEEKTHLQE------KLRLQHEME------LK 734
Query: 136 EDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVT--FRRHFLE 193
+ + + R R+ L + S W E+ ++G L +E +T +H LE
Sbjct: 735 ARLTQAQASFEREREGL--QSSAWTEEK------VRGLTQELEQFHQEQLTSLVEKHTLE 786
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
+ L + + E + T C R T +++ + ++ R + L L +
Sbjct: 787 KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 846
Query: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
++ K+ E+ +E KSQ + EK EL E LL ++ K+ + ++ RE +
Sbjct: 847 RQELKDLQEQQREE---KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREML 903
Query: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
E H M E E+ ++ + TQ + + S H+ L
Sbjct: 904 EKTYKEHLNSMVVERQQLLQDLEDLRNVSE-----TQQSLLSDQILELKSSHKRELRERE 958
Query: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ Q + + L R + ++ Q++ +L + + D+ E
Sbjct: 959 EVLCQAGASEQLASQRLERLEMEHDQER-QEMMSKLLAMENIHKATCETADRERAEMSTE 1017
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
RLQ E LQ + +E A L+Q ++LE+ +
Sbjct: 1018 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG------D 1071
Query: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
V L LQ Q KE + ++ R ++RLQ++ GL S L E T +
Sbjct: 1072 VLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLV--MSSCLDEPATEFFGNTAEQ 1128
Query: 554 LEGELLRQEQTEVTAALARA-------EQSIAEL----SSSENTLKTEVADLRAAAVKLS 602
E L+Q +T+ + R + + +L +SS + ++ + A+ S
Sbjct: 1129 TE-PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1187
Query: 603 AL--NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
L +E + L Q+ QL+E+ +C+ + A + + L D++ +K+ +
Sbjct: 1188 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLK----- 1242
Query: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL-------SESRHQQEAATTQLEQL 713
L++ EA + + D+ E + +Q++L E+ + T ++ +L
Sbjct: 1243 ------MLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1296
Query: 714 HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERD-----RQDLAEQLQGLSSAKEL 768
E K+ EEV + L EK+ EV+++ E + Q E+LQ S +
Sbjct: 1297 QDELKKMEEV------TETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ--ESVVQR 1348
Query: 769 LESSLFEAQQQNSVIEVTKGQLEVQ----------------IQTVTQAKEVIQGEVRCLK 812
+ L+EA +N IE L++ I+ Q + ++G + L+
Sbjct: 1349 CDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE 1408
Query: 813 LELDTERS------QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
E + Q QER Q+ E + + H+ + +L E E+
Sbjct: 1409 KVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAEL----ELEK 1464
Query: 867 SWHQQELAKAL--------------------ESLEREKMELEMRLKEQQTEMEAIQAQRE 906
+ QEL + L E L+ +L++ E Q ++E + + E
Sbjct: 1465 T-KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL--RYE 1521
Query: 907 EERTQAESALCQMQLETEKERVSL----LETLLQTQKELADASQQLERLRQDMKVQKLKE 962
E+ Q E+++ + ++ T E S+ L TL +Q+E+ ++ ++ +++ VQK+ E
Sbjct: 1522 SEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVK--QENAAVQKMVE 1579
Query: 963 QETTGILQTQLQEAQRELK--EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
I + +++ Q +L+ E ++++ + LQE + L + M QK+ E S L
Sbjct: 1580 NLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE--MLCQKEKEPGNSAL- 1636
Query: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080
E+ QEK +E R + + +SL L E + + ++Q+ + + +
Sbjct: 1637 ---------EEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1687
Query: 1081 ELSALRQ--DMQEAQGEQKELSAQMELLRQEVKEKEA---------DFLAQEAQLLEELE 1129
EL ++Q + Q+++S+ + + +KEKEA D LA ++ LLE
Sbjct: 1688 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLA-KSSLLEHRI 1746
Query: 1130 ASHITEQQ--------LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ--AQ 1179
A+ EQ+ L++ L A + K L+ +++ Q+ + ++ + Q + +
Sbjct: 1747 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1806
Query: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAE 1239
++ SL+ LQ A GG AP + +G + KR LS +
Sbjct: 1807 QEVMSLHKQLQNA------------GGKSWAPEI---ATHPSGLHNQQKR------LSWD 1845
Query: 1240 AVASALHKLHQDLWK--------TQQTRDVL---RDQVQKLEERL-------TDTEAEKS 1281
+ +++ Q LW+ Q T+ L R++V++LE L + +
Sbjct: 1846 KLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMN 1905
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGK---QNSLESELMELHETMASLQSRLRRAELQRME 1338
E L+R+ Q Q+E+S K NSLE EL +H L+ + + + Q ME
Sbjct: 1906 PTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLME 1965
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
Q R + ++ LQ Q + + E L+L+ + +++E
Sbjct: 1966 MQHLRSTATPSPSPHAWDLQLLQ--------QQACPMVPREQF------LQLQRQLLQAE 2011
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
R Q LQE+ E + ++ Q N L + ER EVE ++ L +++ Q
Sbjct: 2012 RIN-QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ 2066
Score = 104 bits (259), Expect = 1e-21
Identities = 174/837 (20%), Positives = 364/837 (43%), Gaps = 101/837 (12%)
Query: 259 EAHERSQELIQ--LKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALRET 312
EA E ++EL + Q +L+K E VTE L +S + NE+ ++ L+
Sbjct: 1281 EALENNKELTAEVFRLQDELKKME---EVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1337
Query: 313 VEILETNHTELME---HEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHEN 367
+E L+ + + + EASL E ++ Q+ + + + + V ++ + EN
Sbjct: 1338 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1397
Query: 368 S-LELDSSIFSQFDYQDADKALTLVRSVLTRRR---QAVQDLRQQLAGCQE-------AV 416
LE ++ + + + +++ R R Q + + L G Q+ +
Sbjct: 1398 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1457
Query: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLA---------GQTVDLQGEVDSLSKEREL 467
L+ + + +E + L++R+ L ++D L+ DLQ + ++ EL
Sbjct: 1458 AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVEL 1517
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
L+ E+L+Q+ +L E L + L+ + G +EE ++ +E +Q+M
Sbjct: 1518 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKM 1577
Query: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
+ L+ + +SEL ++ + L E TE++ ++ ++ + EL N
Sbjct: 1578 VENLK----KQISEL----------KIKNQQLDLENTELSQKNSQNQEKLQEL----NQR 1619
Query: 588 KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
TE+ + SAL E +K L ++L + + ++ ++ S +EA +L
Sbjct: 1620 LTEMLCQKEKEPGNSALEER-EQEKFNLKEELERCKVQSSTLVSSLEA----------EL 1668
Query: 648 AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQ 703
+E + + + ++N L+ +L+K ++ DL D Q++ + +K L E
Sbjct: 1669 SEVKIQTHIVQQENHLLKDELEKMKQ--LHRCPDLSDFQQKISSVLSYNEKLLKEKEALS 1726
Query: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
E + +++L ++ E +A QE+++ + A+L+ +L A + Q+L + +Q ++
Sbjct: 1727 EELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1785
Query: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
++S L QQ+ ++ L Q+Q + E+ T S
Sbjct: 1786 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG---------KSWAPEIATHPSGLH 1836
Query: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES--LE 881
++ ++L+ + + EQQ E E Q + K H +E + LES L
Sbjct: 1837 NQQ----KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1892
Query: 882 REKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALCQM-QLETEKERVSL-LETL 934
+ + L TE E + +RE +E++ A + QM LE E E + L E L
Sbjct: 1893 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1952
Query: 935 LQTQKELADASQQLERLRQD---------MKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
+ Q +L + +++ LR +Q L++Q + + Q + QR+L +A R
Sbjct: 1953 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2012
Query: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
++ L+ +S + + ++ V ++ +++ + +LV++ +QEK+ + +E
Sbjct: 2013 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2069
Score = 92.0 bits (227), Expect = 6e-18
Identities = 170/744 (22%), Positives = 304/744 (40%), Gaps = 127/744 (17%)
Query: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
L+ ++ +L+L L T+ + Q K R LE + ++R+KEK
Sbjct: 339 LDGNINLTELTLALENELLVTKNSIHQAALASFKAEI---RHLLERVDQVVREKEK---- 391
Query: 1741 QQEHIHELQELKDQLEQQLQGLHRKV---GETSL--LLSQREQEIVVLQQQLQEAREQGE 1795
+ + + ++LK + ++ H + E +L L + ++ I L+ +L++ REQ
Sbjct: 392 LRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ-- 449
Query: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
L Q ++ L+QE ++A+ +E ++++ + L
Sbjct: 450 ---------------ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 494
Query: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
E +L +++ +L+ L L E GDL S E +++ +
Sbjct: 495 ENAEKLAEYENLTNKLQRNLE------NVLAEKFGDLDPSSAE----FFLQEERLTQMRN 544
Query: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH- 1974
E+E + R LQD + Q+ L+E + LR ++S +E A + + LG
Sbjct: 545 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 604
Query: 1975 -----------AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Q KEQH + L LE + LD ++ +E ++ +
Sbjct: 605 NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH 664
Query: 2024 G------EIQDQDLRYQEDVQQLQQAL---AQRDEELRHQQEREQLL-----EKSLAQ-- 2067
E Q DL+ + Q Q A+ A + RH++E++QL EK+ Q
Sbjct: 665 ENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEK 724
Query: 2068 -RVQENM------IQEKQNLGQERE--------EEEIRGLHQSVREL---QLT------L 2103
R+Q M Q + + +ERE EE++RGL Q + + QLT
Sbjct: 725 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 784
Query: 2104 AQKEQEILELRETQQRNNLEALPH-----SHKTSPMEEQ------------SLKLDSLEP 2146
+KE+ EL E QR E + +TS +E Q L SLE
Sbjct: 785 LEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 844
Query: 2147 RLQRELERLQAALRQTEAR-EIEWREKAQDLALSLAQTKASVSSLQEVAMFL--QASVLE 2203
R ++EL+ LQ R+ +++ E E E Q+ A + K ++ + ++ L + +LE
Sbjct: 845 RYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE 904
Query: 2204 RD---------SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254
+ E+Q+L +LE R E ++ S + EL S ++ ++ E
Sbjct: 905 KTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ--SLLSDQILELKSSHKRELREREEVLC 962
Query: 2255 EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
+A S ++ R +EH Q+ R E+ L N+ ++T E +RER ++ E
Sbjct: 963 QAGASEQLASQRLERLEMEHDQE---RQEMMSKLLAMENIH-KATCETADRERAEMSTEI 1018
Query: 2315 MRAAQAGSLEISKATASSPTQQDG 2338
R Q+ E+ +AT+ Q G
Sbjct: 1019 SR-LQSKIKEMQQATSPLSMLQSG 1041
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 212 bits (540), Expect = 3e-54
Identities = 399/1914 (20%), Positives = 799/1914 (41%), Gaps = 286/1914 (14%)
Query: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329
L ++ + +A L E+ LL + + + EK+ L + ++ +E+ +H A+
Sbjct: 351 LVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAA 410
Query: 330 LSRNAQEEKLSLQQVIKD----ITQVMVEEGDNIAQGSGHENSLELDSSI---FSQFDYQ 382
+ R + L + K+ + + +E + I Q +G + LEL+ I ++ +Y
Sbjct: 411 IERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQR-LELEQEIEKAKTEENYI 469
Query: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ--------QQHDQWEEEGKALR 434
AL+L + +R + + ++LA + N LQ ++ +
Sbjct: 470 RDRLALSLKEN--SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFF 527
Query: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
+ ++LT R+ Q LQ +VD L E EE R Q VL V
Sbjct: 528 LQEERLTQMRNEYERQCRVLQDQVDELQSE-------LEEYRAQGRVLRLPLKNSPSEEV 580
Query: 495 ELQLQG-DSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESS- 552
E G + G E+ L++++ E + +E + + ++ LR LE
Sbjct: 581 EANSGGIEPEHGLGSEECNPLNMSI-------EAELVIEQMKEQHHRDICCLRLELEDKV 633
Query: 553 -HLEGELLRQEQTEVTAALARAEQSIAELSSSE-NTLKTEVADLRAAAVKLSALNEALAL 610
H E +L E + +A++++ + +E +TL+ +++DL+ +L
Sbjct: 634 RHYEKQL-----DETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQ-------- 680
Query: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Q + E +++ C E+ + LQV L E+ THL+ +L+
Sbjct: 681 -----GQAAVLKEAHHEATCRH----EEEKKQLQVKLE----------EEKTHLQEKLRL 721
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE---AATTQLEQLHQEAKRQEEVLARA 727
E EL+A L Q E ++ L S +E T +LEQ HQE +
Sbjct: 722 QHE--MELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ-------LTS 772
Query: 728 VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
+ EK L +E E+R + +E+ +++L E + + + +S EAQ Q+ +VT+
Sbjct: 773 LVEKHTLEKE----ELRKELLEKHQRELQEGREKMETECN-RRTSQIEAQFQSDCQKVTE 827
Query: 788 GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847
+ E +Q++ + + E++ L+ + E+SQ E E+D ++ A+A++ K L+++
Sbjct: 828 -RCESALQSL---EGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 848 KAAHEKEVNQLREKWEKERSWH-------QQELAKALESLER-----------EKMELEM 889
K + Q RE EK H +Q+L + LE L + +EL+
Sbjct: 884 KTT-SLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKS 942
Query: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
K + E E + Q A L ++++E ++ER ++ LL + + +
Sbjct: 943 SHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD 1002
Query: 950 RLRQDMKVQ------KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
R R +M + K+KE + + LQ + + E D +L ++ LL+
Sbjct: 1003 RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGE-EEVEGDGALSLLQQGEQLLE 1061
Query: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
+ D+ + QR EQ V+E ++ E +R+Q+ L++ + L +S
Sbjct: 1062 ENGDVLLSL-------------QRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMS--- 1105
Query: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
S L + E G E Q E Q+ + K+ + + +
Sbjct: 1106 -------------------SCLDEPATEFFGNTAE---QTEPFLQQNRTKQVEGVTRR-H 1142
Query: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
+L +LE + + L + + Q Q +++ +E+ +E + + +L
Sbjct: 1143 VLSDLEDDEVRD------LGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWEL 1196
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
+ S LQ+ L +C S E Q+ + L L A
Sbjct: 1197 KNQISQLQEQLMMLCADCDRAS------------EKKQDLLFDVSVLKKKLKMLERIPEA 1244
Query: 1243 SALHK-LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301
S +K L++D+ + D L+++++ +E R + ++ E+ LQ +L
Sbjct: 1245 SPKYKLLYEDV---SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL------- 1294
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
++ E+ ET SL+ ++ E E L L ++E LQ
Sbjct: 1295 -----------KKMEEVTETFLSLEKSYDEVKI-------ENEELNVLVLRLQGKIEKLQ 1336
Query: 1362 AAVVEARAQASAAGILEE-DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
+VV+ LE ++ + L+L N+ +E R +++ E + + L+
Sbjct: 1337 ESVVQRCDCCLWEASLENLEIEPDGNILQL-NQTLEECVPRVRSVHHVIEECKQENQYLE 1395
Query: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
N LL + A E+ L G IQ +++ +Q + + L + Q I
Sbjct: 1396 GNTQLLEKVKA---HEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIA 1452
Query: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL--ELEKKDQMI 1538
ELE ++ L+ L ++ER L Q++ + EK+ E + + + Q+ E+++K +++
Sbjct: 1453 ELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL 1512
Query: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTH 1592
+ ++Q + ++ E L E++ ++ Q+++ ++ E ++ + A+
Sbjct: 1513 RYESEKLQQ-ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQ-ENAAVQK 1570
Query: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL--QRQKEHLT 1650
+ +L+++ EL+ ++ Q+ DLE +T L+++ + ++++ +++ E+ Q++KE
Sbjct: 1571 MVENLKKQISELKIKNQQL-DLE--NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGN 1627
Query: 1651 QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
LE R+QE KE ++ + Q + LE +L ++K+ Q ++Q+
Sbjct: 1628 SALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKI-----------QTHIVQQE- 1675
Query: 1711 EEGKGPSKAQRGSLEHMKLI-----LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
+ + LE MK + L D ++++ + +L + K+ L ++L K
Sbjct: 1676 ------NHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDK 1729
Query: 1766 VGETSLL------LSQR----EQEIVVLQQQLQEAREQGELKEQSLQS---QLDEAQRAL 1812
+ ++SLL + Q E + L+ QL ++E+ + E ++Q+ Q+ + L
Sbjct: 1730 LAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDL 1789
Query: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA--HMTLKERHGELQDHKEQARR 1870
QE EAL+QE Q + K+ A + A + H K + DH
Sbjct: 1790 RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDH-----L 1844
Query: 1871 LEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQ 1930
+ EE + + + L+ ++ + +AE + + L+ + Q+H L
Sbjct: 1845 MNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKH-----------LN 1893
Query: 1931 AQAVLKERDQELEALRAE-SQSSRHQEEAAR--ARAEALQEALGKAHAALQG--KEQHLL 1985
+ +QE +L+ E Q + Q A R ++ +L++ L H +G K+Q L
Sbjct: 1894 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKL 1953
Query: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQ 2042
++ + STAT S A Q + R Q ++Q Q L+ + Q LQ+
Sbjct: 1954 DEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQE 2013
Query: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096
L R E Q ++ L + +R+ E +++K L + +E++ L + V
Sbjct: 2014 ELENRTSETNTPQGNQEQLVTVMEERMIE--VEQKLKLVKRLLQEKVNQLKEQV 2065
Score = 202 bits (515), Expect = 3e-51
Identities = 356/1733 (20%), Positives = 707/1733 (40%), Gaps = 269/1733 (15%)
Query: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789
E E LV + + + L + + + + L E++ + KE L S L +A++ S++
Sbjct: 347 ENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDD 406
Query: 790 LEVQIQ-----TVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
I+ + + E + + LK EL ER Q Q+ A +Q + EQE + A
Sbjct: 407 HHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQ---AGKQRLELEQEIEKAK 463
Query: 845 EQQKAAHEKEVNQLRE--KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
++ ++ L+E + E E + ++LA+ + + LE L E+ +++
Sbjct: 464 TEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSS 523
Query: 903 AQ--REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960
A+ +EER L QM+ E E++ L + + + Q EL + Q LR +K
Sbjct: 524 AEFFLQEER------LTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPS 577
Query: 961 KEQETT--------GILQTQLQ------EAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
+E E G+ + EA+ +++ QH D+ L ++
Sbjct: 578 EEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCL----------RL 627
Query: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
+L+ +V + QL D + ++ QE +++ E LE++ + L + E +
Sbjct: 628 ELEDKVRHYEKQL----DETVVSCKKAQENMKQRHENET--HTLEKQISDLKNEIAELQG 681
Query: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL-- 1124
+ VL+EA E + ++ E+K+L ++E + ++EK L E +L
Sbjct: 682 QAAVLKEA----HHEATCRHEE------EKKQLQVKLEEEKTHLQEKLR--LQHEMELKA 729
Query: 1125 -LEELEASHITEQQ-LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
L + +AS E++ L++S W +E ++R +LE EQ
Sbjct: 730 RLTQAQASFEREREGLQSSAWTEE--------KVRGLTQELEQFHQEQ------------ 769
Query: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
L S +++ E R EL LE Q + E +
Sbjct: 770 --LTSLVEKHTLEKEELRKEL------------LEKHQRELQE-----------GREKME 804
Query: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT-EAEKSQVHTELQDLQRQLSQNQEEK 1301
+ ++ +T Q + QK+ ER ++ + + EL+DLQ Q +EEK
Sbjct: 805 TECNR------RTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQ---QREEK 855
Query: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
S+WE +++ L E E E L+ L+R + + ERE+L+ + EHL
Sbjct: 856 SQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLTQEREMLEKTYK------EHLN 906
Query: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
+ VVE + L T +S L + E++S +R L+E+ E+ G + Q
Sbjct: 907 SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRE--LREREEVLCQAGASEQL 964
Query: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQE 1481
L + E ++E + + ++ +E + KA E + + + E+ Q +I+E
Sbjct: 965 ASQRLERLEMEHDQERQEMMSKLLAMEN---IHKATCETADRERAEMSTEISRLQSKIKE 1021
Query: 1482 LEKCRSVLEHLPMAVQ-------EREQKLTVQREQIRELEKDRE---TQRNVLEHQLLEL 1531
+++ S L L Q E + L++ ++ + LE++ + + + E + E
Sbjct: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081
Query: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
K I + ++Q L+ LV CL E Q + + ++ + V
Sbjct: 1082 VKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRR 1141
Query: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQ 1651
H+ DLE+ ++ DL S T + + + +E ++ E EL+ +E T+
Sbjct: 1142 HVLSDLED---------DEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTE 1192
Query: 1652 DLERRDQELMLQKERIQVLED----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
E ++Q LQ++ + + D +Q + + + + KL + ER E + + +L+
Sbjct: 1193 SWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLY 1252
Query: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
E S+ E ++++ ++ +E +E E+ L+D+L++ +V
Sbjct: 1253 EDV------SRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKM-----EEVT 1301
Query: 1768 ETSLLLSQREQEIVVLQQQLQEA--REQGELK---------------EQSLQSQLDEAQR 1810
ET L L + E+ + ++L R QG+++ E SL++ E
Sbjct: 1302 ETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDG 1361
Query: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHK 1865
+ Q +Q LE + E K++ L+G + +AH + HG +Q H+
Sbjct: 1362 NILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAH-EIAWLHGTIQTHQ 1420
Query: 1866 EQARRLEEELAVEGRRVQALEE-------VLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
E+ R + + E + ++ + +L E + ++ L+++ ++ +
Sbjct: 1421 ERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKD 1480
Query: 1919 VETRALQDSWLQA-----QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
V + ++ L+A Q E Q++E LR ES+ + + R L E +
Sbjct: 1481 VLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSIS 1540
Query: 1974 H---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
+ L G ++ + ++ E + A+ + +L + + + L ++ E+ ++
Sbjct: 1541 NLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKN 1600
Query: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
+ QE +Q+L Q L E+ Q+E+E E QEK NL +E E +++
Sbjct: 1601 SQNQEKLQELNQRLT----EMLCQKEKEP------GNSALEEREQEKFNLKEELERCKVQ 1650
Query: 2091 GLHQ-SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL---EP 2146
S E +L+ + + I++ ++ LE + H+ + + K+ S+
Sbjct: 1651 SSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNE 1710
Query: 2147 RLQRELERLQAALRQT----------EAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
+L +E E L L E R +++ + A K+ + + QE
Sbjct: 1711 KLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQN 1770
Query: 2197 LQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA 2256
L+ +V + + R++ +L +T++ EKE L + +L + G G+ E
Sbjct: 1771 LEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLHKQLQNAG------GKSWAPEI 1822
Query: 2257 EPSPDGMEKQSWR---QRLEHLQQAVARL---------------------------EIDR 2286
P G+ Q R +L+HL +L +++
Sbjct: 1823 ATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLES 1882
Query: 2287 SRLQRHNVQLR--STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+ L +H L T+ E+E+ LKRE + + S K + + +Q+
Sbjct: 1883 NLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQE 1935
Score = 195 bits (496), Expect = 4e-49
Identities = 373/1848 (20%), Positives = 765/1848 (41%), Gaps = 236/1848 (12%)
Query: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
E QE+L L+ SL I L E + LE ELL + + AALA + I L
Sbjct: 320 ENSQEILKALDF----SLDGNINLTELTLA--LENELLVTKNSIHQAALASFKAEIRHLL 373
Query: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
+ + E LR+ K L +A + ++ +E N+ +++ E+ +
Sbjct: 374 ERVDQVVREKEKLRSDLDKAEKLKSLMASE---VDDHHAAIERRNEYNLRKLD--EEYKE 428
Query: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701
+ E K RE + LQ+A + EL+ ++ + E+ I+ +L+ S
Sbjct: 429 RIAALKNELRKEREQI----------LQQAGKQRLELEQEIEKAKTEENYIRDRLALSLK 478
Query: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK--------AALEVRLQAVERDRQ 753
+ +L + ++ E + + + E ++ EK A ++ + + + R
Sbjct: 479 ENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRN 538
Query: 754 DLAEQLQGLSSAKELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRC 810
+ Q + L + L+S L E + Q V+ + EV+ + E G C
Sbjct: 539 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
Query: 811 LKLELDTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L + E EQ ++ R + E LE + +EK++++ +K +
Sbjct: 599 NPLNMSIEAELVIEQMKEQHHRDICCLRLE----LEDKVRHYEKQLDETVVSCKKAQENM 654
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
+Q +LE++ +L+ + E Q + ++ E + E Q+Q++ E+E+
Sbjct: 655 KQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH 714
Query: 930 LLETL-----LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
L E L ++ + L A ER R+ ++ E++ G+ Q Q Q +L
Sbjct: 715 LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLV 774
Query: 985 RQH---RDDL--AALQEESSSLLQDKMDLQKQVEDLKSQLVA--QDDSQRLVEQ------ 1031
+H +++L L++ L + + ++ + SQ+ A Q D Q++ E+
Sbjct: 775 EKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
Query: 1032 ----EVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRL---LVLQEADSI-----R 1078
+++L++ QE R +K + E EK LT E ++ L L ++ S+ R
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQER 894
Query: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138
+ ++ + E+++L +E LR V E + L+ + + EL++SH E +
Sbjct: 895 EMLEKTYKEHLNSMVVERQQLLQDLEDLR-NVSETQQSLLSDQ---ILELKSSHKRELRE 950
Query: 1139 RASLWAQEAKAAQL------QLRLRSTESQLEALAAEQQPGNQAQA--------QAQLAS 1184
R + Q + QL +L + + + E ++ N +A +A++++
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMST 1010
Query: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
S LQ + + ++ LS + E + +GA SL ++G L + + + S
Sbjct: 1011 EISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLS- 1069
Query: 1245 LHKLHQDLWK------TQQTRDVLRDQVQKLEERLT-----DTEAEKSQVHTELQD---L 1290
L + H+ K T+ +R L+ ++QKLE L D A + +T Q L
Sbjct: 1070 LQRAHEQAVKENVKMATEISR--LQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFL 1127
Query: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHET-MASLQSRLRRAELQRMEAQGERELLQAA 1349
Q+ ++ E ++ + + E+ +L T +S+Q + + E +G EL +
Sbjct: 1128 QQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSE 1187
Query: 1350 KE-----NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
+ L Q+ LQ ++ A A ++DL S LK K + +E E +
Sbjct: 1188 ETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK 1247
Query: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
+ E + LQE L ++ E E + L ++ L+ + + + E L
Sbjct: 1248 YKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETF-LS 1306
Query: 1465 LKKRNQEVDLQQEQIQELE-KCRSVLEHLPMAVQER---------EQKLTVQRE----QI 1510
L+K EV ++ E++ L + + +E L +V +R + L ++ + Q+
Sbjct: 1307 LEKSYDEVKIENEELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366
Query: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE--------- 1561
+ ++ + + H + E ++++Q +E ++ +K + ++
Sbjct: 1367 NQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ 1426
Query: 1562 ----LEENHHKMECQQKLIKELE--GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
LEEN + Q K + + E ++ L LT L+ER L Q D+
Sbjct: 1427 NQVILEENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQK----DVL 1482
Query: 1616 SHSTVLARELQERDQEVKSQREQIE----ELQRQKEHLTQDLERRDQELMLQKERIQVLE 1671
SH E+++E+K+ ++ E+Q++ E L + E+ QE + + I L
Sbjct: 1483 SHG--------EKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLN 1534
Query: 1672 DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK--- 1728
+ E+ + +KL L ++ M ++ E K + A + +E++K
Sbjct: 1535 E---------EDSISNLKLG------TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
Query: 1729 --LILRDKEKEVECQQ------EHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
L +++++ ++E + ++ +LQEL +L + L ++ G ++ L +REQE
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSA--LEEREQEK 1637
Query: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA 1840
L+++L+ + Q SL+++L E + QE L+ E ++ + Q R + +
Sbjct: 1638 FNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLS 1696
Query: 1841 D---ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
D + L LKE+ ++ +L + +E R+ +++ +S
Sbjct: 1697 DFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLE-HRIATMKQEQKSWEHQSA 1755
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957
+ L+A Q++ Q E V+ LQ S +++ L+ QE EAL+ E S Q
Sbjct: 1756 SLKSQLVASQEKV--QNLEDTVQNVNLQMSRMKSD--LRVTQQEKEALKQEVMSLHKQ-- 1809
Query: 1958 AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE 2017
LQ A GK+ A L + S + + + +L+
Sbjct: 1810 --------LQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQT 1861
Query: 2018 ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQE 2071
++ + E+ +E V+QL+ L + ++ + E+E+L K + Q+
Sbjct: 1862 MVQNTKAELTHS----REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQK 1917
Query: 2072 NMIQEKQNLGQERE-EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHK 2130
+ + Q E+E+ +H L+ + +++++E++ + PH+
Sbjct: 1918 EQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWD 1977
Query: 2131 TSPMEEQSLKLDSLEPRLQRELERLQA-ALRQTEAREIEWREKAQDLALSLAQTKASVSS 2189
+++Q+ + E LQ + + LQA + Q E+E R ++T +
Sbjct: 1978 LQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENR---------TSETNTPQGN 2028
Query: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALE------KERLHSPG 2231
+++ ++ ++E ++ +L+L +R L+ KE++ PG
Sbjct: 2029 QEQLVTVMEERMIE-------VEQKLKLVKRLLQEKVNQLKEQVSLPG 2069
Score = 179 bits (455), Expect = 2e-44
Identities = 344/1666 (20%), Positives = 682/1666 (40%), Gaps = 251/1666 (15%)
Query: 855 VNQLREKWEKERSWHQQELAKALE-SLERE--------KMELEMRLKEQQTEMEAIQAQR 905
V ++ + W++E + QE+ KAL+ SL+ +E E+ + + A+ + +
Sbjct: 307 VERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFK 366
Query: 906 EEERTQAESALCQMQLETEKERVSL-----LETLLQTQKELADASQQLERLRQDMKVQKL 960
E R E + Q+ E EK R L L++L+ + E+ D +ER R + ++KL
Sbjct: 367 AEIRHLLE-RVDQVVREKEKLRSDLDKAEKLKSLMAS--EVDDHHAAIER-RNEYNLRKL 422
Query: 961 KEQ--ETTGILQTQLQEAQRELKEAARQHRDDLAALQEES---SSLLQDKMDLQ-KQVED 1014
E+ E L+ +L++ + ++ + A + R +L E++ + ++D++ L K+
Sbjct: 423 DEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSR 482
Query: 1015 LKSQLVAQDDSQRLVEQE-VQEKLRETQEYNRIQK---------ELEREKASLTLSLMEK 1064
L+++L+ +++++L E E + KL+ E +K E ++ LT E
Sbjct: 483 LENELL--ENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY 540
Query: 1065 EQRLLVLQEADSIRQQELS-------ALRQDMQEAQGEQKE------------------- 1098
E++ VLQ+ Q EL LR ++ + E+ E
Sbjct: 541 ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
Query: 1099 --LSAQMELLRQEVKEKE-----------ADFLAQEAQLLEELEAS-------------- 1131
+S + EL+ +++KE+ D + + L+E S
Sbjct: 601 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 1132 --HITEQQLR------ASLWAQEA--KAAQLQLRLRSTE--SQLEALAAEQQPGNQAQAQ 1179
H E+Q+ A L Q A K A + R E QL+ E++ Q + +
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR 720
Query: 1180 AQ-LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD-----QNGARSLFKRGPLL 1233
Q L + L QA S R L + V GL + Q SL ++
Sbjct: 721 LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEK---- 776
Query: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL-----TDTEAEKSQVHTELQ 1288
L E + L + HQ + Q+ R+ + + + ++ +D + + + LQ
Sbjct: 777 HTLEKEELRKELLEKHQR--ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQ 834
Query: 1289 DLQRQL--------SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
L+ + Q +EEKS+WE +++ L E E E L+ L+R + +
Sbjct: 835 SLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL---LKETLKREKTTSLVLT 891
Query: 1341 GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
ERE+L+ + EHL + VVE + L T +S L + E++S +
Sbjct: 892 QEREMLEKTYK------EHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHK 945
Query: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460
R L+E+ E+ G + Q L + E ++E + + ++ +E + KA E
Sbjct: 946 R--ELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAME---NIHKATCET 1000
Query: 1461 LSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ---EREQK------LTVQREQIR 1511
+ + + E+ Q +I+E+++ S L L Q E E + L Q EQ+
Sbjct: 1001 ADRERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLL 1060
Query: 1512 ELEKD-RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
E D + + E + E K I + ++Q L+ LV CL E
Sbjct: 1061 EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTA 1120
Query: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Q + + ++ + V H+ DLE+ ++ DL S T + + + +
Sbjct: 1121 EQTEPFLQQNRTKQVEGVTRRHVLSDLED---------DEVRDLGSTGTSSVQRQEVKIE 1171
Query: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED----QRTRQTKILEEDLE 1686
E ++ E EL+ +E T+ E ++Q LQ++ + + D +Q + + +
Sbjct: 1172 ESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVL 1231
Query: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
+ KL + ER E + + +L+ E S+ E ++++ ++ +E +E
Sbjct: 1232 KKKLKMLERIPEASPKYKLLYEDV------SRENDCLQEELRMMETRYDEALENNKELTA 1285
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ--EAREQGELK------- 1797
E+ L+D+L++ +V ET L L + E+ + ++L R QG+++
Sbjct: 1286 EVFRLQDELKKM-----EEVTETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQESVV 1340
Query: 1798 --------EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE- 1848
E SL++ E + Q +Q LE + E K++ L+G +
Sbjct: 1341 QRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQL 1400
Query: 1849 ----QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE-------VLGDLRAESR 1897
+AH + HG +Q H+E+ R + + E + ++ + +L E
Sbjct: 1401 LEKVKAH-EIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEKT 1459
Query: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQA-----QAVLKERDQELEALRAESQSS 1952
+ ++ L+++ ++ +V + ++ L+A Q E Q++E LR ES+
Sbjct: 1460 KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKL 1519
Query: 1953 RHQEEAARARAEALQEALGKAH---AALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
+ + R L E ++ L G ++ + ++ E + A+ + +L
Sbjct: 1520 QQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQI 1579
Query: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
+ + + L ++ E+ ++ + QE +Q+L Q L E+ Q+E+E
Sbjct: 1580 SELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLT----EMLCQKEKEP------GNSA 1629
Query: 2070 QENMIQEKQNLGQEREEEEIR-GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
E QEK NL +E E +++ S E +L+ + + I++ ++ LE +
Sbjct: 1630 LEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMKQL 1689
Query: 2129 HKTSPMEEQSLKLDSL---EPRLQRELERLQAALRQ----------TEAREIEWREKAQD 2175
H+ + + K+ S+ +L +E E L L E R +++ +
Sbjct: 1690 HRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKS 1749
Query: 2176 LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATST 2235
A K+ + + QE L+ +V + + R++ +L +T++ EKE L +
Sbjct: 1750 WEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQ--EKEALKQEVMSLH 1807
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ----SWRQRLEHLQQAVARLEIDRSRLQR 2291
+L + G G+ E P G+ Q SW +L+HL +L + +R
Sbjct: 1808 KQLQNAG------GKSWAPEIATHPSGLHNQQKRLSW-DKLDHLMNEEQQLLWQEN--ER 1858
Query: 2292 HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
+++T ++ R K+++ ++ + +PT+Q+
Sbjct: 1859 LQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQE 1904
Score = 144 bits (362), Expect = 1e-33
Identities = 326/1556 (20%), Positives = 623/1556 (40%), Gaps = 237/1556 (15%)
Query: 16 LQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEK 75
L+L LE++V ++Q+ E + + +N + QR L+ ++ ++ EL+
Sbjct: 625 LRLELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAELQG 681
Query: 76 RLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALR 135
+ + EE +L V+LEEE+ + +LRL E L+
Sbjct: 682 QAAVLKEAHHEATCRHEEEK-KQLQVKLEEEKTHLQE------KLRLQHEME------LK 728
Query: 136 EDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVT--FRRHFLE 193
+ + + R R+ L + S W E+ ++G L +E +T +H LE
Sbjct: 729 ARLTQAQASFEREREGL--QSSAWTEEK------VRGLTQELEQFHQEQLTSLVEKHTLE 780
Query: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
+ L + + E + T C R T +++ + ++ R + L L +
Sbjct: 781 KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY 840
Query: 254 QELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
++ K+ E+ +E KSQ + EK EL E LL ++ K+ + ++ RE +
Sbjct: 841 RQELKDLQEQQREE---KSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREML 897
Query: 314 EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS 373
E H M E E+ ++ + TQ + + S H+ L
Sbjct: 898 EKTYKEHLNSMVVERQQLLQDLEDLRNVSE-----TQQSLLSDQILELKSSHKRELRERE 952
Query: 374 SIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL 433
+ Q + + L R + ++ Q++ +L + + D+ E
Sbjct: 953 EVLCQAGASEQLASQRLERLEMEHDQER-QEMMSKLLAMENIHKATCETADRERAEMSTE 1011
Query: 434 RQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN 493
RLQ E LQ + +E A L+Q ++LE+ +
Sbjct: 1012 ISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENG------D 1065
Query: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
V L LQ Q KE + ++ R ++RLQ++ GL S L E T +
Sbjct: 1066 VLLSLQRAHEQAVKENVKMATEIS-RLQQRLQKLEPGLV--MSSCLDEPATEFFGNTAEQ 1122
Query: 554 LEGELLRQEQTEVTAALARA-------EQSIAEL----SSSENTLKTEVADLRAAAVKLS 602
E L+Q +T+ + R + + +L +SS + ++ + A+ S
Sbjct: 1123 TE-PFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFS 1181
Query: 603 AL--NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660
L +E + L Q+ QL+E+ +C+ + A + + L D++ +K+ +
Sbjct: 1182 ELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLK----- 1236
Query: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL-------SESRHQQEAATTQLEQL 713
L++ EA + + D+ E + +Q++L E+ + T ++ +L
Sbjct: 1237 ------MLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRL 1290
Query: 714 HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERD-----RQDLAEQLQGLSSAKEL 768
E K+ EEV + L EK+ EV+++ E + Q E+LQ S +
Sbjct: 1291 QDELKKMEEV------TETFLSLEKSYDEVKIENEELNVLVLRLQGKIEKLQ--ESVVQR 1342
Query: 769 LESSLFEAQQQNSVIEVTKGQLEVQ----------------IQTVTQAKEVIQGEVRCLK 812
+ L+EA +N IE L++ I+ Q + ++G + L+
Sbjct: 1343 CDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLE 1402
Query: 813 LELDTERS------QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER 866
E + Q QER Q+ E + + H+ + +L E E+
Sbjct: 1403 KVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATIAEL----ELEK 1458
Query: 867 SWHQQELAKAL--------------------ESLEREKMELEMRLKEQQTEMEAIQAQRE 906
+ QEL + L E L+ +L++ E Q ++E + + E
Sbjct: 1459 T-KLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELL--RYE 1515
Query: 907 EERTQAESALCQMQLETEKERVSL----LETLLQTQKELADASQQLERLRQDMKVQKLKE 962
E+ Q E+++ + ++ T E S+ L TL +Q+E+ ++ ++ +++ VQK+ E
Sbjct: 1516 SEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVK--QENAAVQKMVE 1573
Query: 963 QETTGILQTQLQEAQRELK--EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
I + +++ Q +L+ E ++++ + LQE + L + M QK+ E S L
Sbjct: 1574 NLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTE--MLCQKEKEPGNSAL- 1630
Query: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080
E+ QEK +E R + + +SL L E + + ++Q+ + + +
Sbjct: 1631 ---------EEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKD 1681
Query: 1081 ELSALRQ--DMQEAQGEQKELSAQMELLRQEVKEKEA---------DFLAQEAQLLEELE 1129
EL ++Q + Q+++S+ + + +KEKEA D LA ++ LLE
Sbjct: 1682 ELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLA-KSSLLEHRI 1740
Query: 1130 ASHITEQQ--------LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ--AQ 1179
A+ EQ+ L++ L A + K L+ +++ Q+ + ++ + Q + +
Sbjct: 1741 ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK 1800
Query: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAE 1239
++ SL+ LQ A GG AP + +G + KR LS +
Sbjct: 1801 QEVMSLHKQLQNA------------GGKSWAPEI---ATHPSGLHNQQKR------LSWD 1839
Query: 1240 AVASALHKLHQDLWK--------TQQTRDVL---RDQVQKLEERL-------TDTEAEKS 1281
+ +++ Q LW+ Q T+ L R++V++LE L + +
Sbjct: 1840 KLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMN 1899
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGK---QNSLESELMELHETMASLQSRLRRAELQRME 1338
E L+R+ Q Q+E+S K NSLE EL +H L+ + + + Q ME
Sbjct: 1900 PTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLME 1959
Query: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
Q R + ++ LQ Q + + E L+L+ + +++E
Sbjct: 1960 MQHLRSTATPSPSPHAWDLQLLQ--------QQACPMVPREQF------LQLQRQLLQAE 2005
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
R Q LQE+ E + ++ Q N L + ER EVE ++ L +++ Q
Sbjct: 2006 RIN-QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQ 2060
Score = 104 bits (259), Expect = 1e-21
Identities = 174/837 (20%), Positives = 364/837 (43%), Gaps = 101/837 (12%)
Query: 259 EAHERSQELIQ--LKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALRET 312
EA E ++EL + Q +L+K E VTE L +S + NE+ ++ L+
Sbjct: 1275 EALENNKELTAEVFRLQDELKKME---EVTETFLSLEKSYDEVKIENEELNVLVLRLQGK 1331
Query: 313 VEILETNHTELME---HEASLSRNAQEEKLSLQQVIKDITQVM--VEEGDNIAQGSGHEN 367
+E L+ + + + EASL E ++ Q+ + + + + V ++ + EN
Sbjct: 1332 IEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEECKQEN 1391
Query: 368 S-LELDSSIFSQFDYQDADKALTLVRSVLTRRR---QAVQDLRQQLAGCQE-------AV 416
LE ++ + + + +++ R R Q + + L G Q+ +
Sbjct: 1392 QYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQHQATI 1451
Query: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLA---------GQTVDLQGEVDSLSKEREL 467
L+ + + +E + L++R+ L ++D L+ DLQ + ++ EL
Sbjct: 1452 AELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVEL 1511
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
L+ E+L+Q+ +L E L + L+ + G +EE ++ +E +Q+M
Sbjct: 1512 LRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKM 1571
Query: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
+ L+ + +SEL ++ + L E TE++ ++ ++ + EL N
Sbjct: 1572 VENLK----KQISEL----------KIKNQQLDLENTELSQKNSQNQEKLQEL----NQR 1613
Query: 588 KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
TE+ + SAL E +K L ++L + + ++ ++ S +EA +L
Sbjct: 1614 LTEMLCQKEKEPGNSALEER-EQEKFNLKEELERCKVQSSTLVSSLEA----------EL 1662
Query: 648 AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQ 703
+E + + + ++N L+ +L+K ++ DL D Q++ + +K L E
Sbjct: 1663 SEVKIQTHIVQQENHLLKDELEKMKQ--LHRCPDLSDFQQKISSVLSYNEKLLKEKEALS 1720
Query: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
E + +++L ++ E +A QE+++ + A+L+ +L A + Q+L + +Q ++
Sbjct: 1721 EELNSCVDKL-AKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1779
Query: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
++S L QQ+ ++ L Q+Q + E+ T S
Sbjct: 1780 LQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGG---------KSWAPEIATHPSGLH 1830
Query: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES--LE 881
++ ++L+ + + EQQ E E Q + K H +E + LES L
Sbjct: 1831 NQQ----KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLP 1886
Query: 882 REKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALCQM-QLETEKERVSL-LETL 934
+ + L TE E + +RE +E++ A + QM LE E E + L E L
Sbjct: 1887 KHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGL 1946
Query: 935 LQTQKELADASQQLERLRQD---------MKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
+ Q +L + +++ LR +Q L++Q + + Q + QR+L +A R
Sbjct: 1947 KKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAER 2006
Query: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
++ L+ +S + + ++ V ++ +++ + +LV++ +QEK+ + +E
Sbjct: 2007 INQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2063
Score = 92.0 bits (227), Expect = 6e-18
Identities = 170/744 (22%), Positives = 304/744 (40%), Gaps = 127/744 (17%)
Query: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
L+ ++ +L+L L T+ + Q K R LE + ++R+KEK
Sbjct: 333 LDGNINLTELTLALENELLVTKNSIHQAALASFKAEI---RHLLERVDQVVREKEK---- 385
Query: 1741 QQEHIHELQELKDQLEQQLQGLHRKV---GETSL--LLSQREQEIVVLQQQLQEAREQGE 1795
+ + + ++LK + ++ H + E +L L + ++ I L+ +L++ REQ
Sbjct: 386 LRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQ-- 443
Query: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
L Q ++ L+QE ++A+ +E ++++ + L
Sbjct: 444 ---------------ILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELL 488
Query: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
E +L +++ +L+ L L E GDL S E +++ +
Sbjct: 489 ENAEKLAEYENLTNKLQRNLE------NVLAEKFGDLDPSSAE----FFLQEERLTQMRN 538
Query: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH- 1974
E+E + R LQD + Q+ L+E + LR ++S +E A + + LG
Sbjct: 539 EYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEEC 598
Query: 1975 -----------AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Q KEQH + L LE + LD ++ +E ++ +
Sbjct: 599 NPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH 658
Query: 2024 G------EIQDQDLRYQEDVQQLQQAL---AQRDEELRHQQEREQLL-----EKSLAQ-- 2067
E Q DL+ + Q Q A+ A + RH++E++QL EK+ Q
Sbjct: 659 ENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEK 718
Query: 2068 -RVQENM------IQEKQNLGQERE--------EEEIRGLHQSVREL---QLT------L 2103
R+Q M Q + + +ERE EE++RGL Q + + QLT
Sbjct: 719 LRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHT 778
Query: 2104 AQKEQEILELRETQQRNNLEALPH-----SHKTSPMEEQ------------SLKLDSLEP 2146
+KE+ EL E QR E + +TS +E Q L SLE
Sbjct: 779 LEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEG 838
Query: 2147 RLQRELERLQAALRQTEAR-EIEWREKAQDLALSLAQTKASVSSLQEVAMFL--QASVLE 2203
R ++EL+ LQ R+ +++ E E E Q+ A + K ++ + ++ L + +LE
Sbjct: 839 RYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLE 898
Query: 2204 RD---------SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254
+ E+Q+L +LE R E ++ S + EL S ++ ++ E
Sbjct: 899 KTYKEHLNSMVVERQQLLQDLEDLRNVSETQQ--SLLSDQILELKSSHKRELREREEVLC 956
Query: 2255 EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
+A S ++ R +EH Q+ R E+ L N+ ++T E +RER ++ E
Sbjct: 957 QAGASEQLASQRLERLEMEHDQE---RQEMMSKLLAMENIH-KATCETADRERAEMSTEI 1012
Query: 2315 MRAAQAGSLEISKATASSPTQQDG 2338
R Q+ E+ +AT+ Q G
Sbjct: 1013 SR-LQSKIKEMQQATSPLSMLQSG 1035
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 210 bits (534), Expect = 2e-53
Identities = 502/2503 (20%), Positives = 1032/2503 (41%), Gaps = 375/2503 (14%)
Query: 22 EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR----------KLQAKVLQYRSWCQ 71
EQ+ +Q +AE ++ K+ + +A +V K +A+V Y+ +
Sbjct: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131
LEK A + + E E +LL EEE + + E+ + R+++EK
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKLK--- 656
Query: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
+ L + + + D L + SQ +F K L + +L+
Sbjct: 657 -------DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI------------- 696
Query: 192 LEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249
LE+ D + L+ K+E + L + L + + Q + G+ + +E L
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEKGTLEQEVQE------L 748
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL----TQSQKQNEDYEKM 305
KT+ LEK+ E+ +L + +Q + E + L+D L +L SQ++ +
Sbjct: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
Query: 306 IKA------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359
IK+ + +EIL + +L + L+ ++++ + K+ E +
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 360 AQGSGHENSLELDSSIFSQFDYQDADKALT--------------LVRSVLTRRRQAVQDL 405
A ++ LE DS + +Y+ KAL + SV + V +
Sbjct: 869 ACLLKVKDDLE-DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927
Query: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465
+ ++ L ++ + + E L QRL L+ + G+ L EV SL +E+
Sbjct: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK 987
Query: 466 ELLQKAREELR--------QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ--EELH 515
E + EL + ++ + + L V + +G K + EE
Sbjct: 988 EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047
Query: 516 LAVRERERLQEMLMGLEAKQSE-------SLSELITLR--EALESSHLEGEL--LRQEQT 564
+ V ++ + M +G E+KQ + S+++ +LR + E+ L+ EL L+ EQ
Sbjct: 1048 IMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQN 1107
Query: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE 624
++ + A++ L S + + L +L E L + +++ +L++
Sbjct: 1108 DLRLQM-EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQK 1163
Query: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL------------------EA 666
+Q M+ E + L K ++A+ E+ ++ E
Sbjct: 1164 IHQLELQTMKTQETGDEGKPLHLL-IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEV 1222
Query: 667 QLQKAEEAG--------AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
+ E +G ELQ ++Q+ +E + L++ + +L +
Sbjct: 1223 NAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWG 1282
Query: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE-AQ 777
+Q + + E+ E L + Q + D+ + + LSS ++L ++ L E Q
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK-LSSLQDLEKTKLEEQVQ 1341
Query: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
+ S+I + QL+ + ++ + E+ CL+ L S++ + E
Sbjct: 1342 ELESLISSLQQQLK-------ETEQNYEAEIHCLQKRLQAV-SESTVPPSLPVDSVVITE 1393
Query: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMR------- 890
+ + + +K ++ E + + + K LE +E++E E+
Sbjct: 1394 SDAQRTMYPGSCV-KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452
Query: 891 -LKEQQTEMEAIQAQREEERTQAES-ALCQ--------MQLETEKERVSLLETL-LQTQK 939
QQTE+ I +E + ++ A+CQ M+L ++ ET+ ++ ++
Sbjct: 1453 IAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
Query: 940 ELADASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
E S++L E L + + E + + ++ ++ + + D+++
Sbjct: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS 1572
Query: 995 QEESSSLLQDKMDLQKQVEDLKSQLVA-----QDDSQRLVEQEVQEKLRETQEYNRIQKE 1049
++S L M ++Q+ED++ +LV Q ++ L + +++ R+ ++ ++Q+E
Sbjct: 1573 SMDASRQL---MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEE 1629
Query: 1050 LER------EKASLTLSLMEKEQRLLVLQEADSIRQQEL-------------SALRQDMQ 1090
++R +++S+ + E+ ++L+E ++++Q L S Q+
Sbjct: 1630 IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN 1689
Query: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA 1150
E QGE +E + + + L ++ ++ + L+ E L++ + L+ L + AA
Sbjct: 1690 ENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK-----ANNRLLKILLEVVKTTAA 1744
Query: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ESRPELSGGG-- 1207
+ R L+ + Q + AS+ S + + V ES P SG
Sbjct: 1745 VEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804
Query: 1208 DSAPSVW------GLEPDQNGARSLF-------KRGPLLTALSA----------EAVASA 1244
+ ++W G E Q RS F + L+ +S+ EA++
Sbjct: 1805 RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET 1864
Query: 1245 LHKL-HQDLWKTQQTRDVLRDQ---------VQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
+L H + +T+ R+ R + ++L ERL + + Q+ EL + +
Sbjct: 1865 SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924
Query: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
+EK+ +E + + L + + +RL+ E ++ + Q ERELL KE +
Sbjct: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK 1984
Query: 1355 A-----------QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE-----VESE 1398
A + E L +E + QA + +DL+ AL++ EE +E E
Sbjct: 1985 AEAGPVEQQLLQETEKLMKEKLEVQCQAEK---VRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-------- 1450
+E+ L + + A K L++ L + +RE E + + +IQ+LE+Q
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQ 2101
Query: 1451 --REMQKAALELLSLDLKKRN---QEVDLQQEQIQ-ELEKCRSVLEHLPMAVQEREQKLT 1504
E Q +E L+ LK++ E+ L +EQ+Q ++++ +E L V+E EQ L
Sbjct: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 1505 VQ-REQIRELEKDRETQRNV-LEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
V+ R+ +E E V L+ + +++K++ I + Q++ +++ LE E+
Sbjct: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE---LENKNEEV 2218
Query: 1563 EENHHKMECQQK----LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS 1618
++ H ++E Q+K ++ELE + + + + L L ++E A S+Q D
Sbjct: 2219 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES----DAMSTQ--DQHVLF 2272
Query: 1619 TVLARELQERDQEVKSQREQIEELQRQ------------KEHLTQDLERRDQELMLQKER 1666
A+ +QE++ E+ EQ+ +LQ+Q K L +DLE + + LM +E
Sbjct: 2273 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2332
Query: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
++ ++ Q L E +E+++ L G++ + + E A+ SL+H
Sbjct: 2333 VKRNREEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEAD-----------SLKH 2378
Query: 1727 -MKLILRDK---EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
+ +++ +K E++VE E E+ +K+ L+ ET+ ++Q QE+
Sbjct: 2379 QLDVVIAEKLALEQQVETANE---EMTFMKNVLK-----------ETNFKMNQLTQELFS 2424
Query: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--EALQQEQQQA--QGQEERVKE 1838
L+++ + + + E S+ +D + + + L +AL+ + Q + EE K
Sbjct: 2425 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG 2484
Query: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
L+ L Q T+ + EL +Q + ++E+ E + L++ + +L+ E
Sbjct: 2485 SIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---TEMLQKKIVNLQKIVEE 2541
Query: 1899 QEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958
+ A L Q Q E QE+ + QD+ + + Q L LR + S A
Sbjct: 2542 KVAAALVSQIQ-LEAVQEY---AKFCQDNQTISSEPERTNIQNLNQLREDELGS--DISA 2595
Query: 1959 ARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
R L+ + + H + L+ ++ + E+ L + E LQ L+ + R+ E
Sbjct: 2596 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK--EKKLLELQKLLEGNEKKQREKE 2653
Query: 2017 EALRIQEGEI---------QDQDLRYQEDVQQLQ-QALAQRDEELRHQQEREQLLEKSLA 2066
+ Q+ E+ +++ + +++ L+ +++A + E ++++ E+L E+ L
Sbjct: 2654 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713
Query: 2067 QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP 2126
+ + NM +++L Q R+ H + + +L++ +KE E E++E+++ E LP
Sbjct: 2714 K--ETNMTSLQKDLSQVRD-------HLAEAKEKLSILEKEDE-TEVQESKKACMFEPLP 2763
Query: 2127 --HSHKTSPMEEQSLKLDSLEPRLQRELE------RLQAALRQTEAREI-----EWREKA 2173
S + + +LK+ S Q ++ LQ+ E EI E EK
Sbjct: 2764 IKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM 2823
Query: 2174 QDL----ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHS 2229
Q+L L + S + + ++ +L+ + + + ++ L
Sbjct: 2824 QELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAH 2883
Query: 2230 PGATSTAEL-----GSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
A T E+ GS QG+ L G + G E +S
Sbjct: 2884 SDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2926
Score = 202 bits (514), Expect = 3e-51
Identities = 465/2369 (19%), Positives = 967/2369 (40%), Gaps = 364/2369 (15%)
Query: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV-------TELSALLTQSQKQNED 301
L K E+E+ E + + ++G + E + + T+L+A L Q++++ ++
Sbjct: 164 LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE 223
Query: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT--QVMVEEGDNI 359
+ L E + L+ +L E + L Q + I Q +EE D++
Sbjct: 224 TMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHL 283
Query: 360 AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV---QDLRQQLAG---CQ 413
+ DYQ + T+ S L + + QD + + + Q
Sbjct: 284 LE------------------DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
E ++++ + + EE K + KLT D L G+ + +++QK +E
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLT-TADKLLGEL------------QEQIVQKNQE 372
Query: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK---EEQQEELHLAVRERERLQEMLMG 530
+LE+ + + QL G + QK ++ Q E + R + Q L
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432
Query: 531 LEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
L A+ E + ++ +++ L H+ + + +T + A +S + ++ +E+ +K
Sbjct: 433 LRAELDEMYGQQIVQMKQELIRQHMAQ--MEEMKTRHKGEMENALRSYSNITVNEDQIKL 490
Query: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
+ +KL N K L ++L + EE C+ E L +
Sbjct: 491 MNVAINELNIKLQDTNS----QKEKLKEELGLILEEK---CALQRQLEDLVEELSFSREQ 543
Query: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
++ R+ + E+ + L + K+ +L+A++ E ++E++ K H+ E +
Sbjct: 544 IQRARQTIAEQESKLN-EAHKSLSTVEDLKAEIVSASESRKELELK-----HEAEVTNYK 597
Query: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS-----S 764
++ L K + VL R + +EA + +R Q + ++L++ + L +
Sbjct: 598 IK-LEMLEKEKNAVLDRMAESQEAELER-----LRTQLLFSHEEELSKLKEDLEIEHRIN 651
Query: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL----DTERS 820
++L ++ +QQ I+ + ++ +I+T+ K+ + + L LE+ D ++S
Sbjct: 652 IEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708
Query: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
+ + Q+ + ++E + ++ EKE L ++ QEL E L
Sbjct: 709 LVNSKSEEMTLQINELQKEIEILRQE-----EKEKGTLEQE--------VQELQLKTELL 755
Query: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
E++ E E L+E+ ++EA + ++E+ E L +++ER+ L+++ K+
Sbjct: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815
Query: 941 LADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
+ +++E L +D+K Q ++ L ++++ + A + + LQEE
Sbjct: 816 -SVWEKEIEILIEENEDLKQQCIQ-------LNEEIEKQRNTFSFAEKNFEVNYQELQEE 867
Query: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
+ LL+ K DL +DS+ E E + KL+ E +Q+ + +
Sbjct: 868 YACLLKVKDDL--------------EDSKNKQELEYKSKLKALNEELHLQR-INPTTVKM 912
Query: 1058 TLSLMEKEQRLLV-LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK--E 1114
S+ ++++ + E + +++ + L + ++ + E+ ELS ++ L +++K+K E
Sbjct: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
Query: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
FL +E + L++ + Q+ LR R +LE + + N
Sbjct: 973 ISFLNEEVKSLKQ--------------------EKEQVSLRCR----ELEIIINHNRAEN 1008
Query: 1175 QAQAQAQLASLYSAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQN---GARSL 1226
Q++SL + + A GSV S+ S G +S V +N G S
Sbjct: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSV--SKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 1227 FKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
++ L L +++ E+ A D K Q+ +VL+ + L ++ S V+
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSEND--KLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124
Query: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ--GE 1342
+ D R+ +N+++K+ SL+ EL+ E ++ + ELQ M+ Q G+
Sbjct: 1125 STHVDQVREYMENEKDKALC-----SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
Query: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+L +A E + ++ L + + E A + ED + + +NE
Sbjct: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYIS-ENE 1238
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE-KQRE 1452
+ E + R + Q + K +E LL L R ++ + +LE +
Sbjct: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL--VLQTRLSKIWGQQTDGMKLEFGEEN 1296
Query: 1453 MQKAALELLSLDLKKRN-QEVDLQQE----QIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507
+ K E LS+ + N +++D+ + +Q+LEK + L VQE E ++ +
Sbjct: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK-----LEEQVQELESLISSLQ 1351
Query: 1508 EQIRELEKDRETQRNVLEHQLLELEKK----DQMIESQRGQVQDLKKQLVTLECLALELE 1563
+Q++E E++ E + + L+ +L + + ++S D ++ + C+ ++
Sbjct: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
Query: 1564 -----ENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLEERSQ----------ELQ 1605
++ + ++K LE Q + Q VA +++ + Q E
Sbjct: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471
Query: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH--LTQDLERRDQELML- 1662
A S Q H + E++ ++ Q + +++ ++E L+++L +E++L
Sbjct: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLS 1531
Query: 1663 ---------QKERIQVLEDQRTRQTK--ILEEDL-EQIKLSLRERGRELTTQRQLMQERA 1710
K+ + + ++ + K I+ + + ++I +S + R+L + +++
Sbjct: 1532 NSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
Query: 1711 EEGKGPSKAQRGSLEHM---KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
+E R EH +L+ + +++E Q+E +LQE +L +QL R
Sbjct: 1592 QE------LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL--AQRSSI 1643
Query: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
+ L+S+RE+ VL ++L+ ++ + L +L R+ + +
Sbjct: 1644 DNENLVSERER---VLLEELEALKQLSLAGREKLCCEL---------RNSSTQTQNGNEN 1691
Query: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Q + +E+ KEK + + ER+ LQ + ++ E+ + A+EE
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYA-LQKANNRLLKILLEVV---KTTAAVEE 1747
Query: 1888 -----VLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDS------------- 1927
VLG L S+ Q A L + + + HE TR +S
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807
Query: 1928 ---WLQAQAVLKERDQEL------------------------------EALRAESQSSRH 1954
W + E Q L + L A S++S
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867
Query: 1955 QEEAARARAEALQEALGKAHAALQGKE------QHLLEQA----ELSRSLEASTATLQAS 2004
E A + E ++E+ + A + + + L E++ +L+ L + +
Sbjct: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
Query: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
D RQ++E I + +Q+L + Q +A Q+ +E R R++ K+
Sbjct: 1928 ADEKTLFERQIQEKTDIIDR--LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Query: 2065 LAQRVQENMIQEKQNLGQEREE-----EEIR-GLHQSVRELQLTLAQKEQEILELRETQQ 2118
A V++ ++QE + L +E+ E E++R L + V+ L++ + E+++ E +Q
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSRFIELEQ 2042
Query: 2119 RNNLEALPHSHKTSPMEEQSLKL---------------DSLEPRLQRELERLQAALRQTE 2163
N E + + +E+Q K+ D + +Q+ ++L+ R
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
Query: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL-ELTRRAL 2222
E + RE + LA L + S L LQ + ER+ E ++L+ + EL + L
Sbjct: 2103 ISEHQTRE-VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 2223 EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
++R H + EL + + + E E + + + +R+ LE+ + V +L
Sbjct: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221
Query: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342
+ +L+ + + L+++E+E + K + + L I ++ A S QD
Sbjct: 2222 HM---QLEIQKKESTTRLQELEQENKLFKDDMEKL----GLAIKESDAMS--TQDQHVLF 2272
Query: 2343 NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP 2402
A+ + E + E+ L Q+T + Q+Q IT + E L L + +
Sbjct: 2273 GKFAQIIQEKEVEIDQLNEQVT--KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2330
Query: 2403 EATV--LEAETRRLD---ESLTQSLTSPG 2426
E E E +L+ E L Q L + G
Sbjct: 2331 ECVKRNREEEIEQLNEVIEKLQQELANIG 2359
Score = 195 bits (495), Expect = 5e-49
Identities = 490/2344 (20%), Positives = 937/2344 (39%), Gaps = 389/2344 (16%)
Query: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALR-------------- 310
+L S DLEK +L+++V EL +L++ Q+Q ++YE I L+
Sbjct: 1324 KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPS 1383
Query: 311 ---ETVEILETNHTELMEHEASLSRNAQE--------------------EKLSLQQVIKD 347
++V I E++ M + + +N EK +Q+ ++
Sbjct: 1384 LPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE 1443
Query: 348 ITQVMVEEGDNIAQ-------GSGHENSL---------ELDSSIFSQFDYQDADKALTLV 391
+ +V+V AQ G EN+ + + F++
Sbjct: 1444 VAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF 1503
Query: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTLAGQ 450
+V + ++ + L ++L + + L HD E + L + + ++ + Q
Sbjct: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563
Query: 451 TVDLQGEVDSLSKERELL--QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508
++ + V S+ R+L+ ++ E++RQ+L QE + EL Q Q +++
Sbjct: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQ 1619
Query: 509 -EQQEELHLAVRE--RERLQEMLMGLEAKQSESLSELITLREALESSHLEG-ELLRQEQT 564
E QE+L ++ R+ Q + E SE L+ EAL+ L G E L E
Sbjct: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679
Query: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-NEALALDKVGLNQQLLQLE 623
+ ++ E+ E T K + D + V L NE AL K N +LL++
Sbjct: 1680 NSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKIL 1735
Query: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
E V A E+ + + + + ++ A L EA A +++ +
Sbjct: 1736 LE---VVKTTAAVEETIGRHVLGILDRSSKSQS--------SASLIWRSEAEASVKSCVH 1784
Query: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
EE + ES + ++ +K EE + + LVR A
Sbjct: 1785 ------EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE----GTELSQRLVRSGFAGT- 1833
Query: 744 RLQAVERDRQDLAEQLQG-LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
++ + ++L + L +A E L ++ E Q +VT Q E+ ++ Q +E
Sbjct: 1834 ---EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT--QTELMRESFRQKQE 1888
Query: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862
+ ++C + EL + + R+ A +L++AE +K E+++
Sbjct: 1889 ATES-LKCQE-ELRERLHEESRAREQLAVELSKAEGV-IDGYADEKTLFERQI------- 1938
Query: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALC 917
QE ++ LE+E + RL+E + E + IQ +RE +E +AE+
Sbjct: 1939 --------QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 918 QMQL--ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975
+ QL ETEK LE Q +K D +Q++ L D++ Q + E T+L +
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050
Query: 976 AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE 1035
+++ + +Q L E++ ++ Q++++ L+ QL Q + E
Sbjct: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISE----- 2105
Query: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS--------IRQQELSALRQ 1087
+T+E ++ L+ + + L+ KEQ +QE + +R+ E + L +
Sbjct: 2106 --HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163
Query: 1088 DMQE--AQGEQKELSAQMELLRQ----EVKEKEADFLAQE-AQLLEELEASHITEQQLRA 1140
D + A + ELS +++L + + KEKE L ++ Q EELE + QQL
Sbjct: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH- 2222
Query: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200
QL+++ + + ++L+ L E + L+ + LG +
Sbjct: 2223 ---------MQLEIQKKESTTRLQELEQENK-------------LFKDDMEKLGLAIKES 2260
Query: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT----- 1255
+S DQ+ F + + + + + KL Q L T
Sbjct: 2261 DAMS------------TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308
Query: 1256 -QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314
++ +++RD ++E ++D E K E++ L + + Q+E + G++ S+ +
Sbjct: 2309 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN-IGQKTSMNAH 2367
Query: 1315 LMELHETMASLQSRL------RRAELQRMEAQGE-----RELLQAAKENLTAQVEHLQAA 1363
L E SL+ +L + A Q++E E + +L+ + + L +
Sbjct: 2368 --SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425
Query: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVE--SERERAQALQEQGELKVAQ--GKA- 1418
E + I E + A L E+E + ++L+ Q K + GK
Sbjct: 2426 KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGS 2485
Query: 1419 ---LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE---- 1471
L+ L L T++ ++ E+ QI+++++Q + + L+ ++L+K +E
Sbjct: 2486 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2545
Query: 1472 ---VDLQQEQIQELEK-CRSVLEHLPMAVQEREQKLTVQR-EQIRELEKDRETQR----- 1521
+Q E +QE K C+ + ++ +Q Q+RE E +
Sbjct: 2546 ALVSQIQLEAVQEYAKFCQD-----NQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2600
Query: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG 1581
+ LE Q++E+ + ++ QV+ +K ++ E LEL++ +E +K +E E
Sbjct: 2601 SELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQK---LLEGNEKKQREKEK 2654
Query: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE 1641
+R Q V + T +L ++E +++ L + S EL ++ + +E++
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713
Query: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED----LEQIKLSLRERGR 1697
+ L +DL + L KE++ +LE + +T++ E E + + L +
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAKEKLSILE--KEDETEVQESKKACMFEPLPIKL---SK 2768
Query: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
+ +Q + + + P + + + L + EC E + E+ + +
Sbjct: 2769 SIASQTDGTLKISSSNQTPQILVKNAGIQINL-------QSECSSEEVTEIISQFTEKIE 2821
Query: 1758 QLQGLH---------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--QSLQSQLD 1806
++Q LH R + ET L +RE + V Q L+E E G LK Q L+S+
Sbjct: 2822 KMQELHAAEILDMESRHISETETL--KREHYVAV--QLLKE--ECGTLKAVIQCLRSKEG 2875
Query: 1807 EAQRALAQRD--QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
+ LA D Q E + GQ ++T H + D
Sbjct: 2876 SSIPELAHSDAYQTREICSSDSGSDWGQ----------------GIYLT----HSQGFDI 2915
Query: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
+ R E E A + +++ G LRA E + +L+L + ++H ++ +
Sbjct: 2916 ASEGRGEESESATD----SFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDHSIQ--QV 2968
Query: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA-EALQEALGKAHAALQGKEQH 1983
+ WL+ + L+ L + Q R E +++ E+ + G+ ALQ Q
Sbjct: 2969 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ---QV 3025
Query: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
LE+ + + + T + DA L E IQ+Q + YQ ++ LQ+A
Sbjct: 3026 FLEERSVLLAAFRTELTALGTTDAV--------GLLNCLEQRIQEQGVEYQAAMECLQKA 3077
Query: 2044 ----LAQRDEELRHQQ-------EREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092
L + L Q +REQ EK +Q + E IQ+KQ+ E + E+ +
Sbjct: 3078 DRRSLLSEIQALHAQMNGRKITLKREQESEKP-SQELLEYNIQQKQSQMLEM-QVELSSM 3135
Query: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLE---ALPHSHKTSPMEEQSLKLDSLEPRLQ 2149
ELQ L+ ++ + EL+ + LE L HK E ++ +L+ + +
Sbjct: 3136 KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVKDKTDE 3194
Query: 2150 RELERLQAALRQTEAREIEW----------------REKAQDLALSLAQTKASVSSLQEV 2193
L A Q ++RE++W +E+ +DL SL K +LQ
Sbjct: 3195 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ--RNLQLN 3252
Query: 2194 AMFLQASVLERDSEQ----QRLQDELELTRR---------ALEKERLHSPGATSTAELGS 2240
+ Q L +S+Q QR+ + +L+ LE E++ +ST +
Sbjct: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER 3312
Query: 2241 RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTL 2300
+Q + +G P P + +++LE + L + + + ++Q R
Sbjct: 3313 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR--- 3369
Query: 2301 EQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQ 2360
+Q+E++R ++ + T + + + GQK + ELQ +V LQ
Sbjct: 3370 QQMEKDR----------------QVHRKTLQTEQEANTEGQKK-----MHELQSKVEDLQ 3408
Query: 2361 AQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
Q LE K++Q Y + + L G+ L + E+ + + L+E T
Sbjct: 3409 RQ--LEEKRQQVY--KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ--NLNEPTTW 3462
Query: 2421 SLTS 2424
SLTS
Sbjct: 3463 SLTS 3466
Score = 176 bits (447), Expect = 2e-43
Identities = 397/1947 (20%), Positives = 803/1947 (41%), Gaps = 293/1947 (15%)
Query: 69 WCQELEKRLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRC-----ESLAEVNTQLR- 121
W + E+ E + + + E +P +EL++ + Q E+++E ++QL
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870
Query: 122 LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181
+ + +++ ++ R+ E + + ++EL + + +E L G +
Sbjct: 1871 AKVTQTELMRESFRQKQE--ATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
Query: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241
E F R E DR EL RL Q E + R
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRL---------------QELEAEQQQIQEER 1973
Query: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
E LL + + ++ EA Q+L+Q + EK E+Q Q++K +D
Sbjct: 1974 E-----LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ----------CQAEKVRDD 2018
Query: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
+K +KAL VE + EL + + + + +++ +L++ ++ + + + E+ +
Sbjct: 2019 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--- 2075
Query: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
E + +F +Q +Q L QQL + V Q
Sbjct: 2076 -------REHERDVF----------------------QQEIQKLEQQL----KVVPRFQP 2102
Query: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
+ E + L L++ T + L LQ ++ ++E E L+ EL Q L V
Sbjct: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 482 LEQ------EAWRLRRVNVELQLQGDSAQGQK------EEQQEELHLAVRER-ERLQEML 528
++ EA + V+LQ + D+ ++ EEQ E+ + + E +Q++
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222
Query: 529 MGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
M LE ++ ES + L L + E +L + + ++ A+ ++S A + ++ L
Sbjct: 2223 MQLEIQKKESTTRLQELEQ-------ENKLFKDDMEKLGLAI---KESDAMSTQDQHVLF 2272
Query: 589 TEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
+ A + + V++ LNE +V QQ L++ +N+ + + E ++ +
Sbjct: 2273 GKFAQIIQEKEVEIDQLNE-----QVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2327
Query: 648 AEAE----KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ 703
++ E R E + + N +E Q+ G + + + EE + ++ +L ++
Sbjct: 2328 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2387
Query: 704 EAATTQLEQLHQEAKRQEEVLARA-------VQEKEALVREKAALEVRLQAVERDRQDLA 756
A Q+E ++E + VL QE +L RE+ ++E ++Q++ + ++A
Sbjct: 2388 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KIQSIPENSVNVA 2446
Query: 757 EQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL- 815
+ LS K LE L E ++ + Q + +I E R L+LE
Sbjct: 2447 --IDHLSKDKPELEVVLTE-----DALKSLENQTYFKSFEENGKGSIINLETRLLQLEST 2499
Query: 816 ----DTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870
D E +Q +Q +D + + E K + QK EK L + + E
Sbjct: 2500 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV--- 2556
Query: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
QE AK + + E E +T ++ + RE+E SAL E E + V +
Sbjct: 2557 QEYAKFCQDNQTISSEPE------RTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2610
Query: 931 LETLLQTQKELADASQQ-LERLRQDMKVQKL------KEQETTGILQTQLQEAQRELKEA 983
+L+ ++++ A + LE+ ++ +++QKL K++E Q E + E
Sbjct: 2611 HTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 2670
Query: 984 ARQHRD-----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQE---VQE 1035
+ + +L AL+ ES + + +++ E L+ +L+ ++ + ++++ V++
Sbjct: 2671 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2730
Query: 1036 KLRETQE-YNRIQKELERE-----KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089
L E +E + ++KE E E KA + L K + + Q +++ + Q +
Sbjct: 2731 HLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2790
Query: 1090 QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE-------ELEASHITEQQ----- 1137
+ G Q ++ Q E +EV E + F + ++ E ++E+ HI+E +
Sbjct: 2791 VKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2848
Query: 1138 --LRASLWAQEAKAAQLQLR-LRSTE-SQLEALAAEQQPGNQAQAQAQLAS-----LYSA 1188
+ L +E + ++ LRS E S + LA + + S +Y
Sbjct: 2849 HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLT 2908
Query: 1189 LQQALGSVCESRPELSGGG-DSAPS-VWGLEPDQNGARSLFKRGPLLTALSAEAVASAL- 1245
Q E R E S DS P + GL R++ G + +L+ +
Sbjct: 2909 HSQGFDIASEGRGEESESATDSFPKKIKGL------LRAVHNEGMQVLSLTESPYSDGED 2962
Query: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE 1305
H + Q + R + + L++ +T + ++ E+ D SQ+ E S W
Sbjct: 2963 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE---AEVYDS----SQSHESFSDWR 3015
Query: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE---LLQAAKENLTAQVEHLQA 1362
G+ L+ L + +S L A + A G + LL ++ + Q QA
Sbjct: 3016 GEL------LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA 3069
Query: 1363 AVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN 1422
A+ E +A +L E ++ + + + ++ E+E + QE E + Q ++
Sbjct: 3070 AM-ECLQKADRRSLLSE-IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS---- 3123
Query: 1423 LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL----QQEQ 1478
+ E + E+ +++ + EL++Q +K + L +L + E++ Q +
Sbjct: 3124 ------QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH 3177
Query: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
++ELE R ++ V L ++++ REL+ LE + +L + +
Sbjct: 3178 LKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW-------ALEKEKAKLGRSE--- 3227
Query: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598
E + +++DLK L + + L+L + +E Q++L+ E + + E+QR+ + +
Sbjct: 3228 ERDKEELEDLKFSLESQKQRNLQL---NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3284
Query: 1599 ERSQELQA--QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
R+ ELQ +S ++ E ST+ +R++E+ +Q + + + + L +
Sbjct: 3285 GRNLELQVLLESEKVRIREMSSTL------DRERELHAQLQSSDGTGQSRPPLPSE---- 3334
Query: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
L KE + LE++ +R ++L E E+ KL + +++ RQ+
Sbjct: 3335 ----DLLKELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQV----------- 3378
Query: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
H K + ++E E Q++ +HELQ + L++QL+ ++V + L QR
Sbjct: 3379 ---------HRKTLQTEQEANTEGQKK-MHELQSKVEDLQRQLEEKRQQVYKLD-LEGQR 3427
Query: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836
Q I+ Q+ + RE+ + L L+E D+ + Q++ + + +E
Sbjct: 3428 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNY 3487
Query: 1837 KEKADALQGA------LEQAHMTLKERHGELQDHKEQA-RRLEEELAVEGRRVQALEEVL 1889
+ + G LE L+ +LQ ++A RL+ E A + + E +
Sbjct: 3488 AKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENI- 3546
Query: 1890 GDLRAESREQEKALLALQQQCAEQAQE 1916
++ +L LQ+ +Q +E
Sbjct: 3547 ----------DEIILQLQKLTGQQGEE 3563
Score = 145 bits (366), Expect = 5e-34
Identities = 280/1392 (20%), Positives = 590/1392 (42%), Gaps = 194/1392 (13%)
Query: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919
E E E + Q E+ + LE ++ +Q E EA QR+ TQ + L Q
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 920 QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979
+ E ++ L EL + SQ+L+ Q ++ + T L +A+++
Sbjct: 218 RREKDETMREFL--------ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
Query: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
+ H+ L EE LL+ D QK+ ED Q+ + ++ E E +K+
Sbjct: 270 I----LTHQQQL----EEQDHLLE---DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318
Query: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
+ + +KE E+ L ++E+E++ L L++ + + L L++ + + E K +
Sbjct: 319 SNKEEIQEKETIIEE--LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376
Query: 1100 SAQMELLRQEVKEKE-ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
++EL + KE++ ++ + Q +EEL+ + + Q + +Q +
Sbjct: 377 --KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI---------VQRMEQE 425
Query: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG--- 1215
T+ +LE L AE ++ Q + ++Q + + E + G ++A +
Sbjct: 426 TQRKLEQLRAEL---DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
+ DQ + + A+++L+ L T Q +KL+E L
Sbjct: 483 VNEDQ-----------------IKLMNVAINELNIKLQDT-------NSQKEKLKEELGL 518
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
EK + +L+DL +LS ++E+ + ES+L E H+++++++ L+ +
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED-LKAEIVS 577
Query: 1336 RMEAQGERELLQAAK-ENLTAQVEHLQA---AVVEARAQASAAGILEEDLRTARSALKLK 1391
E++ E EL A+ N ++E L+ AV++ A++ E +L R+ L
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-----EAELERLRTQLLFS 632
Query: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
+EE S+ + ++ + + + L++NL + +++++ L+ ++ + +
Sbjct: 633 HEEELSKLKEDLEIEHRINI-----EKLKDNLGI------HYKQQIDGLQNEMSQKIETM 681
Query: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
+ +K L + Q + I E+ K + + + L V + +++T+Q +++
Sbjct: 682 QFEKDNL-------------ITKQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQ 725
Query: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
E+ + E ++ LE ++ EL+ K +++E Q + ++ +L+E +
Sbjct: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-------------DLQEKFAQ 772
Query: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD--LESHSTVLARELQ 1626
+E + ++K + ++ + + H + EER L + S+ D E +L E +
Sbjct: 773 LEAENSILK--DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830
Query: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
+ Q+ E+IE+ + ++ E QE LQ+E +L+ + + +++LE
Sbjct: 831 DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE--LQEEYACLLKVKDDLEDSKNKQELE 888
Query: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
K L+ EL QR K + + K + + + E ++
Sbjct: 889 -YKSKLKALNEELHLQR--------INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQEAREQGELKEQSLQ- 1802
EL E + +++ L +++ + S L Q+ EI L ++ L++ +EQ L+ + L+
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999
Query: 1803 ----SQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERV-----KEKADALQGALEQAHM 1852
++ + Q Q L+ + + A+G +V +E ++ + +M
Sbjct: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059
Query: 1853 TLKERHGELQ---DH-----KEQARRLEE--ELAVEGRRVQALEEVLGDLRAESREQEKA 1902
T+ E + Q DH KE + R + E + + L+ DLR + Q
Sbjct: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
Query: 1903 LLALQQQCAEQAQEHEVETR-----ALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQE 1956
L + +Q +E+ + +L++ + AQ +E+ +EL+ + + E Q+ + QE
Sbjct: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQE 1176
Query: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016
+ L +GK A+ + + L Q S E T L+ ++A + +
Sbjct: 1177 TGDEGK--PLHLLIGKLQKAVSEECSYFL-QTLCSVLGEYYTPALKCEVNA-EDKENSGD 1232
Query: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076
++ E+QD Y+ +VQ Q+ + ++ + + +L+ L++ +
Sbjct: 1233 YISENEDPELQD----YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
Query: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
K G+E L ++E E L + Q NLE + +HK+
Sbjct: 1289 KLEFGEE------------------NLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSL 1328
Query: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Q L+ LE ++Q ELE L ++L+Q + +E E +A+ L S S++
Sbjct: 1329 QDLEKTKLEEQVQ-ELESLISSLQQ-QLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV 1386
Query: 2197 LQASVLERDSEQ 2208
+ E D+++
Sbjct: 1387 DSVVITESDAQR 1398
Score = 139 bits (349), Expect = 4e-32
Identities = 182/914 (19%), Positives = 400/914 (43%), Gaps = 91/914 (9%)
Query: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--------RQLSQNQEEKSKWE 1305
+T + ++LR++ +++ ++ A+ S H E+ + + +L++ EE
Sbjct: 126 RTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTY 185
Query: 1306 GKQ-----NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360
G + E+ + + + L + L++A ++ E E L + L Q + L
Sbjct: 186 GTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245
Query: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
QA+ + S+ DL A+ + +++E + + Q++ E Q LQ
Sbjct: 246 QASETLRNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 1421 ENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQ 1476
E + + E++++VE + + +IQE E E + E +L+LK + D
Sbjct: 303 EKIKVYEM---EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359
Query: 1477 EQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQIREL-----------EKDRETQRNVL 1524
++QE + + ++++ + + +QK E+I++L KD + + +++
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419
Query: 1525 EHQLLELEKKDQMIESQRG-----QVQDLKKQLVTLECLALELEENHHKMECQQKL---- 1575
+ E ++K + + ++ Q+ +K++L+ +E + HK E + L
Sbjct: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 479
Query: 1576 -IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634
I E Q + VA+ L + L++ + + + ++ + L R+L++ +E+
Sbjct: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLE----QIK 1689
REQI+ ++ L + L ++ + +++ +R+ L+ + E +IK
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
L + E+ + R + AE + ++ E + + D E EH ++
Sbjct: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE------IEHRINIE 653
Query: 1750 ELKDQL----EQQLQGLHRKVGETSLLLSQREQEIVVLQQQL-QEAREQGELKEQSLQSQ 1804
+LKD L +QQ+ GL ++ + + + ++ Q QL E + +L++ + S+
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
+E + + +E+E L+QE+++ E+ V+E LQ E +KE+ +LQ
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE----LQLKTELLEKQMKEKENDLQ-- 767
Query: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRA 1923
E+ +LE E ++ + LE++L S+E+ L +++ + + E E+E
Sbjct: 768 -EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826
Query: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983
++ L+ Q + L E + R+ A E + L + +A L K +
Sbjct: 827 EENEDLKQQCI---------QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL-KVKD 876
Query: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043
LE ++ + LE + L+A + + H +++ + + D+D + + ++ +
Sbjct: 877 DLEDSKNKQELEYK-SKLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
Query: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
+ + EL + E + + L+QR+ + Q KQ G EI L++ V+ L+
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG------EISFLNEEVKSLK--- 984
Query: 2104 AQKEQEILELRETQ 2117
+KEQ L RE +
Sbjct: 985 QEKEQVSLRCRELE 998
Score = 61.2 bits (147), Expect = 1e-08
Identities = 129/644 (20%), Positives = 261/644 (40%), Gaps = 70/644 (10%)
Query: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE---QAHMTLKERHGELQ 1862
+E Q+ L +L +Q + Q+ GQ K+K + + AH L +
Sbjct: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63
Query: 1863 D-HKEQARRLEEELAVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
+ + ++R+E + E ++ L E+ + S E E + C+ +
Sbjct: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123
Query: 1920 ETR-------------ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966
R + DS+ + A ++ LE + +E +H+ E E +
Sbjct: 124 VMRTGKPTNLLREEEFGVDDSYSEQGA--QDSPTHLEMMESELAGKQHEIEELNRELEEM 181
Query: 1967 QEALG-KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQ 2022
+ G + LQ E + ++ + L A+ + D +L E L+IQ
Sbjct: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241
Query: 2023 EGEIQ-DQDLRYQEDVQQLQQALAQRDEELRHQQ---EREQLLEKSLAQR----VQENMI 2074
++Q + LR L + + L HQQ E++ LLE ++ +Q + +
Sbjct: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301
Query: 2075 QEK---QNLGQERE-----EEEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEA 2124
QEK + Q+++ +EEI+ + EL + ++E++ LEL++ T L
Sbjct: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
Query: 2125 LPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
L E +++KL+ E + E+++L + + + R + + D+
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 2180 LAQ-TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR---ALEKERLHSPGATST 2235
+ Q T+ + L+ + L+ QQ +Q + EL R+ +E+ + G
Sbjct: 422 MEQETQRKLEQLR--------AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
Query: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
A L S V ++ + + ++ Q + E L++ + + ++ LQR Q
Sbjct: 474 A-LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR---Q 529
Query: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL--- 2352
L +E++ R +++R A+ S ++++A S T +D + + S ++ EL
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQES-KLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 2353 -QKEVVLLQAQLTLERKQKQDYITRSAQTSR-ELAGLHHSLSHS 2394
+ EV + +L + K+K + R A++ EL L L S
Sbjct: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
Score = 59.7 bits (143), Expect = 3e-08
Identities = 137/677 (20%), Positives = 273/677 (40%), Gaps = 93/677 (13%)
Query: 124 MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183
++KAD ++L +++ L + + L R++ + QE + ++ + ++L + E
Sbjct: 3074 LQKAD--RRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3131
Query: 184 VVTFRRHFLEMKSATDRDLM---ELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--SGRM 238
+ + + E++ + M ELK+E + L T T+ AQ + + R+
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRL 3186
Query: 239 DGREPAQLLLLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRVTELSALLT 293
+ ++ + LL T E++ Q E +L + +K EL+D L +
Sbjct: 3187 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246
Query: 294 QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
++ + N E+ + L E+ + +E+ M ++A LS Q L LQ V+ + +V +
Sbjct: 3247 RNLQLNLLLEQQKQLLNESQQKIESQR---MLYDAQLSEE-QGRNLELQ-VLLESEKVRI 3301
Query: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
E ++L+ + + +Q D T +++L++QL
Sbjct: 3302 RE---------MSSTLDRERELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKH 3348
Query: 414 EAVNLLQQQHDQWEEEGKALRQRLQK-LTGERDTLAGQ---TVDLQGEVDSLSKERELLQ 469
+ L + ++++ + RQ+++K R TL + + Q ++ L + E LQ
Sbjct: 3349 SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3408
Query: 470 KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--------- 520
+ EE RQQ+ L+ E RL+ + E Q Q + + +K E + L+ + E
Sbjct: 3409 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3467
Query: 521 RERLQEMLMGLEAKQSES-LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
R R + +E + ES ++LI + + E E++RQ+ V + L Q +E
Sbjct: 3468 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527
Query: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
L+ E AD +E + +++ +LQL++
Sbjct: 3528 ------RLQFETAD-----------DEDFIWVQENIDEIILQLQK--------------- 3555
Query: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KL 696
L + +L +T + ++ AEL + + EEK +++ KL
Sbjct: 3556 -------LTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608
Query: 697 SES-RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
E R ++ + + A EKE REK L+ L+ E + L
Sbjct: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3668
Query: 756 AEQLQGLSSAKELLESS 772
+L+ S + L S
Sbjct: 3669 KAELRNDSLLQTLSPDS 3685
Score = 51.6 bits (122), Expect = 9e-06
Identities = 128/681 (18%), Positives = 271/681 (39%), Gaps = 130/681 (19%)
Query: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT---LVRKLQAKVLQYRSWCQEL 73
Q +LE + Q QM E Q + E Q++ ++ +V +L++++ Q + EL
Sbjct: 3111 QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKL---EL 3167
Query: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
E L+A + +L EL E + + + + +N L +K+ + A
Sbjct: 3168 ETTLKA------------QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3215
Query: 134 LREDVEKLTVDWSRARDEL--MRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191
L ++ KL R ++EL ++ + Q ++ L + +LL+ ++ + +R
Sbjct: 3216 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275
Query: 192 LEMKSATD--RDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL 246
+ + + + R+L + L++E VR+ T + AQ + +G+G+ P++
Sbjct: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335
Query: 247 LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI 306
LL +EL+K+ E+ +++L ++ + K L +L T+ Q + +
Sbjct: 3336 LL-----KELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKD------ 3375
Query: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
H + ++ E + Q++ LQ ++D+ + + E+ + +
Sbjct: 3376 ----------RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG 3425
Query: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
L+ I +F Q+ ++ +R++ + L Q L + W
Sbjct: 3426 QRLQ---GIMQEFQKQELERE---------EKRESRRILYQNL-----------NEPTTW 3462
Query: 427 EEEGKALRQRL--QKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
R + QK+ GE +++ + +++ G + E E++++ + + +L+VL
Sbjct: 3463 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3522
Query: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543
Q+A S + Q E +E + V+E + E+++ L+ + E
Sbjct: 3523 QKA---------------SERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPS 3565
Query: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
+ + L LLRQ AEL+ + L E DLR +KL
Sbjct: 3566 LVSPSTSCGSLTERLLRQN---------------AELTGHISQLTEEKNDLRNMVMKLEE 3610
Query: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Q+ Q+ R ++ + N A +E +
Sbjct: 3611 -----------------QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT 3653
Query: 664 LEAQLQKAEEAGAELQADLRD 684
L+ L++AE +L+A+LR+
Sbjct: 3654 LQKSLKRAEAEVYKLKAELRN 3674
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 210 bits (534), Expect = 2e-53
Identities = 425/1930 (22%), Positives = 791/1930 (40%), Gaps = 266/1930 (13%)
Query: 244 AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYE 303
AQL L A Q+ ++ A +E+ L S+ E A LQ R LL + Q E E
Sbjct: 260 AQLELTQANLQKEKETALTELREM--LNSRRAQELALLQSRQQHELELLRE-QHAREKEE 316
Query: 304 KMIKALRETVEILETNHTELMEHEASLSRNAQEE-----KLSLQQVIKDIT---QVMVEE 355
+++ +E E+ E +E ME A + + +E+ L L+ + K+++ Q +E+
Sbjct: 317 VVLRCGQEAAELKEKLQSE-MEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMED 375
Query: 356 GDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEA 415
N Q E EL+ +QD ++A +R++ + + A++ LR+ L E
Sbjct: 376 LQNQFQKELAEQRAELEKI------FQDKNQAERALRNLESHHQAAIEKLREDLQS--EH 427
Query: 416 VNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
L+ +++E K + L+ L + L Q+ Q E+ L + + + +R+EL
Sbjct: 428 GRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQS---QEEIRRLWSQLDSARTSRQEL 484
Query: 476 RQQLEVLEQEAWRLRRV-NVELQLQGDSAQGQKEEQQEELHLAVRERER----------L 524
E+ EQ R RV ++E Q + Q + E +Q ++ + R+ L
Sbjct: 485 S---ELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLL 541
Query: 525 QEMLMGLEAKQSESLSEL------ITLREALESSH------LEGELLRQEQTEVTAALAR 572
Q+ L G A++ L + + L E E LE E ++ A L
Sbjct: 542 QQRLQG--AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEE 599
Query: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD-KVGLNQQL----LQLEEENQ 627
+ + E S ++ E V+ SAL L+ G +Q+L LQ ++
Sbjct: 600 SHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGD 659
Query: 628 SVCSRMEAAE----QARNALQVDLAEAEKRREA--LWEKNTHLEAQLQKAEEAGAELQAD 681
AA + + +Q+ L + E + E L +N +L +LQ L+ D
Sbjct: 660 LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHE----TRLKDD 715
Query: 682 LRDIQEEK-EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV----R 736
L ++ E+ QK+L+ ++ + E + ++ + K +E L R +EK L+ R
Sbjct: 716 LEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELR 775
Query: 737 EKAALEVRLQAVERD-RQDLAEQLQGLSSAKEL-LESSLFEAQQQNSVIE--VTKGQLEV 792
EKA E + + + R+ QLQ +A+ L LE SL E Q + +E +T
Sbjct: 776 EKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALH 835
Query: 793 QIQTVTQAKEVIQGEVRCLK------LELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Q + GE+ L L+L RS+ +ER + + AEQ+ L++
Sbjct: 836 CSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS-AEQDA--FLQE 892
Query: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM----ELEMRLKEQQTEMEAIQ 902
+ H +E+ L+E+ HQQ+L LE EL L+ +Q + A +
Sbjct: 893 AQEQHARELQLLQER-------HQQQLLSVTAELEARHQAALGELTASLESKQGALLAAR 945
Query: 903 AQREEERTQAE-SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
+ + A+ AL L + S + QT +E + Q LE LR D + Q K
Sbjct: 946 VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIRE--EHRQALELLRADFEEQLWK 1003
Query: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM--DLQKQVEDLKSQL 1019
+ + TQ EL++ R+H +L ++++ + + ++ + +++ +
Sbjct: 1004 KDSLHQTILTQ------ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGE 1057
Query: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
+ L E+E +L+ Q Q + EK SL+L L +K ++ L++
Sbjct: 1058 FGSEKKTALHEKEETLRLQSAQA----QPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLS 1113
Query: 1080 QELSALRQDM----QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
E+ R ++ Q + E +E + + +L+ +V ++ A + L L +
Sbjct: 1114 HEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLG---LFG 1170
Query: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG-NQAQAQAQLASLYSALQQA-- 1192
+ LRA++ + ++ L L + LA P + + L L L +
Sbjct: 1171 ETLRAAVTLRSRIGERVGLCLDDAGA---GLALSTAPALEETWSDVALPELDRTLSECAE 1227
Query: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR------GPLLTALSAEAVASALH 1246
+ SV E + +P + + R +F+ G + AL +
Sbjct: 1228 MSSVAEISSHMRESFLMSPE--SVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEAR 1285
Query: 1247 KLHQDL-----WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS----QN 1297
++H +K ++T V+R Q+L E L + A K+++ EL Q L +
Sbjct: 1286 QIHSRFEKEFSFKNEETAQVVRKH-QELLECLKEESAAKAELALELHKTQGTLEGFKVET 1344
Query: 1298 QEEKSKWEGKQNSLESELMELHETMASLQSRLR-----RAELQRMEAQGERELL--QAAK 1350
+ K GK++S ++EL LQ + R E R+ ++GE +A +
Sbjct: 1345 ADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEARE 1404
Query: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410
L +VE L E R QA E+D S +K+ E+E + + + +Q E
Sbjct: 1405 AALRKEVEDLTKEQSETRKQA------EKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
Query: 1411 LKVAQ-------GKALQENLALLTQTLAEREEEVETLRGQIQELEKQ------------R 1451
A K L+ + + AERE E E + +IQ LE Q R
Sbjct: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
Query: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER--EQKLTVQREQ 1509
+ Q+A L+ EV+L Q++++E + E +A+Q+ ++++ +Q E+
Sbjct: 1519 DSQQAPLD----------GEVELLQQKLRE-----KLDEFNELAIQKESADRQVLMQEEE 1563
Query: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN---- 1565
I+ LE+ R + E+EK+ +++ + LKKQ ++ LA L+
Sbjct: 1564 IKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAG 1623
Query: 1566 --------------HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611
++E Q+ + E + + L + DLE +++E+ + ++
Sbjct: 1624 RCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKL 1683
Query: 1612 HDLESHSTVLARELQERDQEVK---SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
S + V REL+E + +K ++ +IEEL+ E+L ++ +R +E + E++
Sbjct: 1684 DMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLH 1743
Query: 1669 VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728
+ ++ + ++ + ++ S + Q R + +G +A + E +
Sbjct: 1744 EVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALS 1803
Query: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
+L D+E+ H L+ L+ +L+ + ++ E ++ RE E+ + ++Q
Sbjct: 1804 RLLADQERR------HSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQ 1857
Query: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
E ++ L + +A+R+ E++AL Q + + E V ++ ALE
Sbjct: 1858 E-----------FEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALE 1906
Query: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Q + ELQ + Q RL +L V +R LR + + L +
Sbjct: 1907 QQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRF---------LRCQ--------VELDR 1949
Query: 1909 QCAEQAQEHE----VETRALQDSWLQAQA---VLKERDQELEALRAESQSSRHQ-----E 1956
+ A +A H + D +AQ V D LE + + Q +
Sbjct: 1950 RQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLK 2009
Query: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQ------- 2009
+A + E + L LQ + LL + E+ SLE + L+ CQ
Sbjct: 2010 DAPLCKQEGVMSVLTVCQRQLQ--SELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLV 2067
Query: 2010 AHSRQLEEAL 2019
A +QL+E L
Sbjct: 2068 AQVKQLQEKL 2077
Score = 182 bits (461), Expect = 5e-45
Identities = 394/1834 (21%), Positives = 740/1834 (40%), Gaps = 277/1834 (15%)
Query: 742 EVRLQAVERDRQDLA--EQLQGLSSAK-ELLESSLFEAQQQNSVIEVTKGQLEVQIQT-V 797
E+ + +E R+D A Q Q + + E L SL + + +E+T+ L+ + +T +
Sbjct: 220 ELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMHTAQLELTQANLQKEKETAL 277
Query: 798 TQAKEVIQG----EVRCLKL----ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849
T+ +E++ E+ L+ EL+ R Q +E++ + Q E K L+ +
Sbjct: 278 TELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEME 337
Query: 850 AHEKEVNQLREKWEKERSWHQQELAKALESLEREKME-----LEMRLKEQQTEMEAIQAQ 904
+ + V L+E WE E+ + L K L + + +ME + L EQ+ E+E I
Sbjct: 338 KNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIF-- 395
Query: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
+++ QAE AL + E + +E L + D + R +D++ K KE E
Sbjct: 396 --QDKNQAERALRNL----ESHHQAAIEKLRE------DLQSEHGRCLEDLEF-KFKESE 442
Query: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Q +L+ Q ++ Q ++++ L + S + +L + E L ++ +D
Sbjct: 443 KEK--QLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
Query: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
++L ++E + Q E E E+ + EK+ L++A+ Q++L+
Sbjct: 501 LEQLKQRE------------KTQHESELEQLRI---YFEKK-----LRDAEKTYQEDLTL 540
Query: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144
L+Q +Q A+ + S ++ L ++EK ++ELE E R
Sbjct: 541 LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDH---VDELEPERHKESLPRFQAEL 597
Query: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCE------ 1198
+E+ QL+ + ES L + E ++ + L+ + G E
Sbjct: 598 EESHRHQLE----ALESPL-CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHL 652
Query: 1199 ---SRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT 1255
+L + A V GLE + SL L T L E + +++L+
Sbjct: 653 QGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIE--NRNLYGK 705
Query: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE- 1314
Q L+D ++K++ L + ++ + +L +Q Q +E + W+ + L+ E
Sbjct: 706 LQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKE--TDWKVMKEELQREA 763
Query: 1315 -------LMELHETMASLQS------RLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
L+EL E S + LR AE+++++ Q ++L + +LT Q LQ
Sbjct: 764 EEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLER-SLTEQQGRLQ 822
Query: 1362 AAVVEARAQAS------------------AAGILEED----LRTARSALKLKNEEVESE- 1398
+ + + AA ++ED L ARS + +E+ +
Sbjct: 823 QLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKF 882
Query: 1399 -RERAQALQEQGELKVAQGKALQE-NLALLTQTLAEREEEVETLRGQIQELEKQREMQKA 1456
E+ LQE E + + LQE + L AE E + G++ + ++
Sbjct: 883 SAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALL 942
Query: 1457 ALELLSLDLKKRNQEVDLQQEQIQELEKCRSV-LEHLPMAVQEREQKLTVQREQIRE-LE 1514
A + L K L+ + L+ S L +E Q L + R E L
Sbjct: 943 AARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLW 1002
Query: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574
K + +L +L +L++K + G++Q ++ L T E
Sbjct: 1003 KKDSLHQTILTQELEKLKRKHE------GELQSVRDHLRT-----------EVSTELAGT 1045
Query: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQ-AQSSQIHDLESHSTVLARELQERDQEVK 1633
+ EL+G + + + L +E + LQ AQ+ H E S L+ +LQ+++ +V+
Sbjct: 1046 VAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKES--LSLQLQKKNHQVQ 1103
Query: 1634 SQREQ-------IEELQRQKEHLTQDLERRDQE----LMLQKERIQVLEDQRTRQTKILE 1682
++Q IEE + + E L Q ER ++E L + K + + +R L+
Sbjct: 1104 QLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGA----LQ 1159
Query: 1683 EDLEQIKLSLRERGRELTTQRQLMQERA-----EEGKGPSKAQRGSLEHM--KLILRDKE 1735
+ L ++ E R T R + ER + G G + + +LE + L + +
Sbjct: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELD 1219
Query: 1736 KEV-ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
+ + EC + + + E+ + + V E EQ I + Q L A +
Sbjct: 1220 RTLSECAE--MSSVAEISSHMRESFLMSPESVREC-------EQPIRRVFQSLSLAVDG- 1269
Query: 1795 ELKEQSLQS--QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHM 1852
L E +L S QL+EA++ ++ ++E +E Q + + + E A + +
Sbjct: 1270 -LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELAL 1328
Query: 1853 TLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912
L + G L+ K + L+E LA + L L LR + LQQ E
Sbjct: 1329 ELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQ----------LQQAAQE 1378
Query: 1913 QAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGK 1972
QA E TR W + +A + + ALR E + ++ R +AE + AL
Sbjct: 1379 QAALREECTRL----WSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434
Query: 1973 AHAALQGK-EQHLLEQAELSRSLEASTATLQ--ASLDACQAHSRQLEEALRIQEGEIQDQ 2029
L+ + E+ L + ++ EA TA Q ASLD H R + + Q E + +
Sbjct: 1435 QMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDK---HLRNQRQFMDEQAAEREHE 1491
Query: 2030 DLRYQEDVQQLQQALAQ---------RDEELRHQQEREQLLEKSLAQRVQE--NMIQEKQ 2078
+Q+++Q+L+ L Q RD + +LL++ L +++ E + +K+
Sbjct: 1492 REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKE 1551
Query: 2079 NLGQE--REEEEIRGLHQSVRELQLTLAQKEQEI-------------LELRETQQRNNL- 2122
+ ++ +EEEI+ L + ++ +AQ ++E+ E+ + QQ ++L
Sbjct: 1552 SADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLL 1611
Query: 2123 -----------EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171
P SP E ++L+ + L R + Q E + +
Sbjct: 1612 LASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLES 1671
Query: 2172 KAQD-------LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ---DELELTRRA 2221
K ++ L + +QT S+ L+E L+ + R SE + L+ + L+ ++
Sbjct: 1672 KNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKV-IYTRSSEIEELKATIENLQENQKR 1730
Query: 2222 LEKER------LHSPGATSTAELGSRGE--QGVQLGEVSGVEAE------PSPDGMEKQS 2267
L+KE+ LH EL G V + +++E P G Q
Sbjct: 1731 LQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQG 1790
Query: 2268 WRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISK 2327
+ ++A++RL D+ R RH+ L + ++++ A AA+ E+ +
Sbjct: 1791 ELEAALEAKEALSRLLADQER--RHSQALEALQQRLQ--------GAEEAAELQLAELER 1840
Query: 2328 ATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLE--RKQKQDYITRSAQTSRELA 2385
A + + + + + + KE + + L ++ ++K + LA
Sbjct: 1841 NVALREAEVEDMASRIQEFEAALK-AKEATIAERNLEIDALNQRKAAHSAELEAVLLALA 1899
Query: 2386 GLHHSLSHSLLAVAQA-PEATVLEAETRRLDESL 2418
+ +L LA A PE L A+ RL L
Sbjct: 1900 RIRRALEQQPLAAGAAPPELQWLRAQCARLSRQL 1933
Score = 174 bits (440), Expect = 1e-42
Identities = 385/1844 (20%), Positives = 745/1844 (40%), Gaps = 292/1844 (15%)
Query: 1 METRSPGLNNMKPQSLQLVL------EEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT 54
+E L+NM L+L +E L ++M ++ A ++L Q QQ +
Sbjct: 247 LEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRA--QELALLQSRQQHELE 304
Query: 55 LVRKLQAK-----VLQYRSWCQELEKRLEATGGP-------IPQRWENVEEPNLDELLVR 102
L+R+ A+ VL+ EL+++L++ + + WE+ ++ L+ L
Sbjct: 305 LLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKE 364
Query: 103 LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQME 162
L + Q + ++ Q + + + R ++EK+ D ++A L ES Q
Sbjct: 365 LSAKHQ--SEMEDLQNQFQKELAEQ-------RAELEKIFQDKNQAERALRNLESHHQAA 415
Query: 163 QEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLR 222
E + L+ EHGR L E + F+ F E + +L L+A + L R
Sbjct: 416 IEKLREDLQSEHGRCL----EDLEFK--FKESEKEKQLELENLQASYEDLKAQSQEEIRR 469
Query: 223 LTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL------EKEAHERSQELIQLKSQGDL 276
L S + + E QLL ++ ++L EK HE E +++ + L
Sbjct: 470 LWSQLDSARTSRQELSELHE--QLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKL 527
Query: 277 EKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE 336
AE + +L+ L + Q ED AL ++VE+ +E + R
Sbjct: 528 RDAE-KTYQEDLTLLQQRLQGARED------ALLDSVEV--GLSCVGLEEKPEKGRKDHV 578
Query: 337 EKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE-LDSSIFSQFDYQDADKALTLVRSVL 395
++L ++ + + + E ++ H + LE L+S + Q + +D+
Sbjct: 579 DELEPERHKESLPRFQAELEES------HRHQLEALESPLCIQHEGHVSDR--------- 623
Query: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
C + L + EG + L G +D +
Sbjct: 624 ----------------CCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
Query: 456 GEVDSLSKEREL-LQKAREELRQQLEVLEQEAWRL-RRVNVELQLQGDSAQGQK---EEQ 510
V L E ++ L + EL++++E+L+ E L ++ E +L+ D + + E+
Sbjct: 668 ARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDH 727
Query: 511 QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE-GELLRQEQTEVTAA 569
Q+EL+ A ++ E +++ E EL REA E L EL + ++E
Sbjct: 728 QKELNNAKQKTELMKQEFQRKETDWKVMKEEL--QREAEEKLTLMLLELREKAESEKQTI 785
Query: 570 LARAEQSIAELSSSENTLKTEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
+ + E AE+ ++ ++ DL R+ + L + L Q L + + S
Sbjct: 786 INKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ--------LEQDLTSDDALHCS 837
Query: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
C R Q + + E + + + ++ LE + + E+ AE A L++ QE+
Sbjct: 838 QCGREPPTAQDGELAALHVKE-DCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
Query: 689 KEEIQKKLSESRHQQE--AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746
+ +L + RHQQ+ + T +LE HQ A E+ A ++ AL+ + A +
Sbjct: 897 HAR-ELQLLQERHQQQLLSVTAELEARHQAA--LGELTASLESKQGALLAARVA-----E 948
Query: 747 AVERDRQDL-AEQLQGLSSAKELLESSLFEAQ----QQNSVIEVTKGQLEVQI------- 794
+ DL A + + LSS L L E Q + +E+ + E Q+
Sbjct: 949 LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLH 1008
Query: 795 -----QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849
Q + + K +GE++ ++ D R++ E Q +G+ E++ A
Sbjct: 1009 QTILTQELEKLKRKHEGELQSVR---DHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTA 1065
Query: 850 AHEKEVNQLREKWEKERSWHQQELAK----------ALESLEREKMELEMRLKEQQTEME 899
HEKE LR + + + +HQ+E ++ L+ + + L ++E ++E+E
Sbjct: 1066 LHEKE-ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELE 1124
Query: 900 AIQAQREEERTQAESALCQMQLE---TEKERVSL---LETLLQTQKELADASQQLERLRQ 953
+Q +RE E + + L ++ + + ER +L L LL E A+ L R R
Sbjct: 1125 VLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTL-RSRI 1183
Query: 954 DMKVQKLKEQETTGIL------------QTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001
+V + G+ L E R L E A +++++ E SS +
Sbjct: 1184 GERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECA-----EMSSVAEISSHM 1238
Query: 1002 LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE----KLRETQEYNRIQKELERE---K 1054
+ + + V + + + S L + E R+ +E +I E+E K
Sbjct: 1239 RESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFK 1298
Query: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
T ++ K Q LL + +S + EL+ ++ + QG + + L++ + KE
Sbjct: 1299 NEETAQVVRKHQELLECLKEESAAKAELAL---ELHKTQGTLEGFKVETADLKEVLAGKE 1355
Query: 1115 ADFLAQEAQLLEELEASHITEQQLR----------ASLWAQ-EAKAAQLQLRLRSTESQL 1163
E +L+ ELE+ QQ LW++ EA A + R + ++
Sbjct: 1356 ----DSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEV 1411
Query: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223
E L EQ + QA+ ++L S ++ + ES LE +
Sbjct: 1412 EDLTKEQSE-TRKQAEKDRSALLSQMK-----ILESE---------------LEEQLSQH 1450
Query: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283
R K+ +TAL + + H LR+Q Q ++E+ + E E+ +
Sbjct: 1451 RGCAKQAEAVTALEQQVASLDKH---------------LRNQRQFMDEQAAEREHEREEF 1495
Query: 1284 HTELQDLQRQLSQ---------NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAEL 1334
E+Q L+ QL Q +++ +G+ L+ +L E + L + A+
Sbjct: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADR 1555
Query: 1335 QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE 1394
Q + + E + L+ N+ +V LQ V + + +E L+ + + L
Sbjct: 1556 QVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLAST 1615
Query: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
++S + A E +G +Q L + + L RE EV L+ Q+++++ E +
Sbjct: 1616 LQSTLD-AGRCPEPPSGSPPEGPEIQ--LEVTQRALLRRESEVLDLKEQLEKMKGDLESK 1672
Query: 1455 KAALELLSLDLKKRNQEV-----DLQQE---------QIQELEKCRSVLEHLPMAVQERE 1500
+ L+L L +N + +L++E + E+E+ ++ +E+L QE +
Sbjct: 1673 NEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENL----QENQ 1728
Query: 1501 QKLTVQREQIRELEKDRETQRNVLEHQL-LELEKKDQMIESQRGQVQ------------- 1546
++L Q+E+ E+E+ E L+H+L L ++ +SQ G +Q
Sbjct: 1729 KRL--QKEKAEEIEQLHEVIEK-LQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRG 1785
Query: 1547 -----DLKKQLVTLECLA-LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
+L+ L E L+ L ++ + + L + L+G E + L L ++ R
Sbjct: 1786 QALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALR 1845
Query: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
E++ +S+I + E+ L+ ++ + + +I+ L ++K + +LE +
Sbjct: 1846 EAEVEDMASRIQEFEA-------ALKAKEATIAERNLEIDALNQRKAAHSAELE----AV 1894
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQ 1704
+L RI+ +Q+ +L+ ++ R+L Q
Sbjct: 1895 LLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQ 1938
Score = 100 bits (249), Expect = 2e-20
Identities = 162/743 (21%), Positives = 307/743 (41%), Gaps = 108/743 (14%)
Query: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324
+ Q++ D + QV E + ++++ Q E + + G S L+E E +
Sbjct: 2438 KTQEVPTACPDWRGDLLQVVQEAFEKEQEM-QGVELQPRLSGSDLGGHSSLLERLEKIIR 2496
Query: 1325 LQSRLRRAELQRMEAQGERELL---QAAKENLTA-------QVEHLQAAVVEARAQASAA 1374
Q L+ L+ + LL QA + L +++HL+ A+ A A+ S
Sbjct: 2497 EQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQ 2556
Query: 1375 GILEEDLRTARSALKLKNEE-----------VESERERAQALQEQGELKVAQGKALQENL 1423
E LR L K E+ + E+E+A ++Q+ + + L+ +L
Sbjct: 2557 ---EHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDL 2613
Query: 1424 A-------LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
L+++L E ++EV LR + K+ E++ A EL S K R + L++
Sbjct: 2614 CESRQKSEQLSRSLCEVQQEVLQLRSMLSS--KENELKAALQELESEQGKGRALQSQLEE 2671
Query: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL---EKDRETQRNVLEHQL-LELE 1532
EQ++ L++ + A++E L QR Q L K +T ++ L+ +L +E
Sbjct: 2672 EQLRHLQRESQSAK----ALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHS 2727
Query: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
+ + ++ +R Q+ +L+K L + LEL E ++L+ E QR TQ +
Sbjct: 2728 RCEALLAQERSQLSELQKDLAAEKSRTLELSEALR----HERLLTEQLSQR-TQEACVHQ 2782
Query: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
T Q+L+ + S++ DL++ + ++ Q+++++ ++ E R+++ ++
Sbjct: 2783 DTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSAT 2842
Query: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
L+ + L QK ++ ++ + L+ +LEQ L+E+ R+ + AE
Sbjct: 2843 LKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQ-----EGRKAARRSAEA 2897
Query: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
+ P+ A E + RDKEK E + + +L ++K
Sbjct: 2898 RQSPAAA-----EQWRKWQRDKEKLRELELQRQRDLHKIKQ------------------- 2933
Query: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
LQQ +++ + E+ L L A+RA + + L+++Q++ +
Sbjct: 2934 ----------LQQTVRDLESKDEVPGSRLH--LGSARRAAGS---DADHLREQQRELEAM 2978
Query: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
+R+ A L QA D E AV + LEE+ DL
Sbjct: 2979 RQRLLSAARLLTSFTSQA-----------VDRTVNDWTSSNEKAVMSL-LHTLEELKSDL 3026
Query: 1893 RAESREQEKALLALQQQCAEQAQEHEVE-TRAL----QDSWLQAQAVLKERDQELEALRA 1947
+ Q+K LQ Q + + V T+AL Q+ ++AV K L+
Sbjct: 3027 SRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQK 3086
Query: 1948 ESQSSRHQEEAARARAEALQEAL 1970
SR + A + A Q +L
Sbjct: 3087 GCSPSRSERSAWKPDETAPQSSL 3109
Score = 97.4 bits (241), Expect = 1e-19
Identities = 167/716 (23%), Positives = 304/716 (42%), Gaps = 82/716 (11%)
Query: 611 DKVGLNQQLLQLEEENQSV--CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
D + + Q+ + E+E Q V R+ ++ ++ ++ E R + ++ + +L
Sbjct: 2452 DLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRL 2511
Query: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
+E+QA ++ + Q+KL R +A + Q + +RQ E+LA V
Sbjct: 2512 PDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKV 2571
Query: 729 QEKEALV----------REKAALEVRLQAVERDR-QDLAEQLQGLSSAKELLESSLFEAQ 777
++++ + +EKA +L A E+ +DL L E L SL E Q
Sbjct: 2572 EQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQ 2631
Query: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837
Q+ + E +++ Q E QG+ R L+ +L+ E+ + Q +A+ L +
Sbjct: 2632 QEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELR 2691
Query: 838 QEGKT----------ALEQQKAAHEKEVNQLREKWEK-------ERSWHQQELAKALESL 880
+T AL+ ++ A + +LR + + ERS EL K L +
Sbjct: 2692 ASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERS-QLSELQKDLAAE 2750
Query: 881 EREKMELEMRLKEQQTEMEAIQAQREE----ERTQAESALCQMQLETEKERVSLLETLLQ 936
+ +EL L+ ++ E + + +E + TQA AL Q +L+ EK RV L+ +L+
Sbjct: 2751 KSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ-KLKEEKSRVVDLQAMLE 2809
Query: 937 -TQKELADASQQLERLRQDMKVQKLKEQETTGILQT---QLQEAQRELKEAARQHRDDLA 992
Q++ + QQLE Q +E+E + L++ L +REL+ + + R+ A
Sbjct: 2810 KVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPA 2869
Query: 993 ALQ---EESSSLLQD---KMDLQKQVEDLKSQLVA------QDDSQRLVEQEVQEK--LR 1038
LQ E+S L++ + ++ E +S A Q D ++L E E+Q + L
Sbjct: 2870 WLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH 2929
Query: 1039 ETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ--ELSALRQDMQEAQGEQ 1096
+ ++ + ++LE + L R +AD +R+Q EL A+RQ + A
Sbjct: 2930 KIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
Query: 1097 KELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR- 1155
++Q + + V + + LL LE + L +Q+ AA+LQ +
Sbjct: 2990 TSFTSQ--AVDRTVNDWTSSNEKAVMSLLHTLEE---LKSDLSRPTSSQKKMAAELQFQF 3044
Query: 1156 ----LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAP 1211
L+ S +AL+ Q + + ++ L L+ L C S
Sbjct: 3045 VDVLLKDNVSLTKALSTVTQ--EKLELSRAVSKLEKLLKHHLQKGCSP-------SRSER 3095
Query: 1212 SVWGLEPDQNGARSLFKR---GPLLTALSAEAVAS--ALHKLHQDLWKTQQTRDVL 1262
S W +PD+ +S +R G L A S EA S + KL+ + + R L
Sbjct: 3096 SAW--KPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKAL 3149
Score = 96.3 bits (238), Expect = 3e-19
Identities = 164/725 (22%), Positives = 295/725 (40%), Gaps = 113/725 (15%)
Query: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
++ +EA E+ QE+ ++ Q L ++L + L L ++Q + EK ++ LR
Sbjct: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
Query: 315 ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS 374
+ + + + ++ +EKL Q + +T A+GS E+ L
Sbjct: 2515 SSLLSEIQALRAQLRMTHLQNQEKL--QHLRTALTSAE-------ARGSQQEHQLR---- 2561
Query: 375 IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434
+ + L+ + + + DL++ L+ QE N +Q+ + + L+
Sbjct: 2562 -----------RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLK 2610
Query: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494
L + + + L+ ++Q EV L R +L EL+ L+ LE E + R +
Sbjct: 2611 SDLCESRQKSEQLSRSLCEVQQEVLQL---RSMLSSKENELKAALQELESEQGKGRALQS 2667
Query: 495 ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR-EALESSH 553
+L+ EEQ L + + L+E+ LE ++++S + L+ E +
Sbjct: 2668 QLE----------EEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
Query: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
L+ E LR E + A LA+ ++EL DL A + L+EAL +++
Sbjct: 2718 LQKE-LRIEHSRCEALLAQERSQLSELQK----------DLAAEKSRTLELSEALRHERL 2766
Query: 614 GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR---REALWEK--------NT 662
L +QL Q Q C + QA +AL L E + R +A+ EK
Sbjct: 2767 -LTEQLSQ---RTQEACVHQDT--QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
Query: 663 HLEAQLQK-------AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
LEA+ QK +E A L++ + + +K E++ L R + +LEQ H
Sbjct: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
Query: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
K QE R + A R+ A + + +RD++ L E E
Sbjct: 2881 RLKEQE---GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE----------------LE 2921
Query: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD---AAARQ 832
Q+Q + ++ + Q QTV + + EV +L L + R A + D R+
Sbjct: 2922 LQRQRDLHKIKQLQ-----QTVRDLES--KDEVPGSRLHLGSARRAAGSDADHLREQQRE 2974
Query: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
L Q +A + + V++ W S +++ + L +LE K +L
Sbjct: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDW---TSSNEKAVMSLLHTLEELKSDLSRPTS 3031
Query: 893 EQQTEMEAIQAQREE-------ERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Q+ +Q Q + T+A S + Q +LE + VS LE LL+ + +
Sbjct: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-AVSKLEKLLKHHLQKGCSP 3090
Query: 946 QQLER 950
+ ER
Sbjct: 3091 SRSER 3095
Score = 94.7 bits (234), Expect = 1e-18
Identities = 145/686 (21%), Positives = 295/686 (43%), Gaps = 93/686 (13%)
Query: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
L ++++K+ D + EKS H L D LS+ Q +++ + +L L
Sbjct: 2487 LLERLEKIIREQGDLQ-EKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTA 2545
Query: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
+ S ++R Q + + + ELL E LQ + E + +A++ +++ L
Sbjct: 2546 LTSAEAR---GSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANS---VQKLL 2599
Query: 1382 RTARSALK-LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440
++ ++ LK++ ES ++ Q + E+ Q+ + L L+ +E E L
Sbjct: 2600 AAEQTVVRDLKSDLCESRQKSEQLSRSLCEV--------QQEVLQLRSMLSSKENE---L 2648
Query: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500
+ +QELE ++ K R + L++EQ++ L++ A++E
Sbjct: 2649 KAALQELESEQG-------------KGRALQSQLEEEQLRHLQR----ESQSAKALEELR 2691
Query: 1501 QKLTVQREQIREL---EKDRETQRNVLEHQL-LELEKKDQMIESQRGQVQDLKKQLVTLE 1556
L QR Q L K +T ++ L+ +L +E + + ++ +R Q+ +L+K L +
Sbjct: 2692 ASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEK 2751
Query: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
LEL E ++L+ E QR TQ + T Q+L+ + S++ DL++
Sbjct: 2752 SRTLELSEALR----HERLLTEQLSQR-TQEACVHQDTQAHHALLQKLKEEKSRVVDLQA 2806
Query: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
+ ++ Q+++++ ++ E R+++ ++ L+ + L QK ++ ++
Sbjct: 2807 MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERERE 2866
Query: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736
+ L+ +LEQ L+E+ R+ + AE + P+ A E + RDKEK
Sbjct: 2867 KPAWLQAELEQSHPRLKEQ-----EGRKAARRSAEARQSPAAA-----EQWRKWQRDKEK 2916
Query: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
E + + +L ++K QL+Q ++ L K E+ + L AR
Sbjct: 2917 LRELELQRQRDLHKIK-QLQQTVRDLESK------------DEVPGSRLHLGSAR----- 2958
Query: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQA---------QGQEERVKEKADALQGAL 1847
++ S D L ++ +ELEA++Q A Q + V + + + A+
Sbjct: 2959 --RAAGSDADH----LREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAV 3012
Query: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV-----QALEEVLGDLRAESREQEKA 1902
TL+E +L +++ EL + V +L + L + E E +A
Sbjct: 3013 MSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
Query: 1903 LLALQQQCAEQAQEHEVETRALQDSW 1928
+ L++ Q+ +R+ + +W
Sbjct: 3073 VSKLEKLLKHHLQKGCSPSRSERSAW 3098
Score = 93.2 bits (230), Expect = 3e-18
Identities = 139/592 (23%), Positives = 252/592 (42%), Gaps = 80/592 (13%)
Query: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954
Q EA + ++E + + + L L + LE +++ Q +L + S LE LR
Sbjct: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKS--LEHLRLP 2512
Query: 955 MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
+ L E + L+ QL+ + +E + R L + + S Q + L++QVE
Sbjct: 2513 DRSSLLSEIQA---LRAQLRMTHLQNQEKLQHLRTALTSAEARGS---QQEHQLRRQVEL 2566
Query: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEY-NRIQKELEREKA-----------------S 1056
L ++ + ++ + ++Q+ L E QE N +QK L E+
Sbjct: 2567 LAYKV----EQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQ 2622
Query: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116
L+ SL E +Q +L L+ S ++ EL A Q+++ QG+ + L +Q+E + ++E+
Sbjct: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRES- 2681
Query: 1117 FLAQEAQLLEELEASHITEQ----QLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
Q A+ LEEL AS T++ +L +L ++ LQ LR S+ EAL A+++
Sbjct: 2682 ---QSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQER- 2737
Query: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232
S S LQ+ L + ELS + L
Sbjct: 2738 -----------SQLSELQKDLAAEKSRTLELS--------------------EALRHERL 2766
Query: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
LT ++ A +HQD Q L ++++ + R+ D +A +V + Q+
Sbjct: 2767 LTEQLSQRTQEAC--VHQD----TQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
Query: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR-RAELQRMEAQGERELLQAAKE 1351
QL ++ + ++ + + L E + + + LR E +R + + L+ +
Sbjct: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
Query: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411
L Q E +AA A A+ S A E+ + R KL+ E++ +R+ + Q Q +
Sbjct: 2881 RLKEQ-EGRKAARRSAEARQSPAA-AEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTV 2938
Query: 1412 KVAQGKALQENLAL-LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462
+ + K L L + + LR Q +ELE R+ +A LL+
Sbjct: 2939 RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLT 2990
Score = 89.4 bits (220), Expect = 4e-17
Identities = 186/864 (21%), Positives = 340/864 (39%), Gaps = 100/864 (11%)
Query: 14 QSLQLVLE---EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQA--KVLQYRS 68
QSL L ++ E L +Q+ E + R K + A +VRK Q + L+ S
Sbjct: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
Query: 69 WCQ-ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
+ EL L T G + VE +L E+L E+ + R E LR +++A
Sbjct: 1321 AAKAELALELHKTQGTL--EGFKVETADLKEVLAGKEDSEHRLVLELE---SLRRQLQQA 1375
Query: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
ALRE+ +L WSR E+ R +L +EV
Sbjct: 1376 AQEQAALREECTRL---WSRGEATATDAEA------------------REAALRKEVEDL 1414
Query: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
+ E + ++D L ++ L L E R ++ +
Sbjct: 1415 TKEQSETRKQAEKDRSALLSQMKILESEL-------------EEQLSQHRGCAKQAEAVT 1461
Query: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE------- 300
L + L+K + Q + + ++ + E+ E Q + L L Q+ K
Sbjct: 1462 ALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQ 1521
Query: 301 ------DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIKDITQVMV 353
+ E + + LRE ++ E N + + A QEE++ L+++ +I + +
Sbjct: 1522 QAPLDGEVELLQQKLREKLD--EFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVA 1579
Query: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
+ + + + LE D + + A TL +S L R G +
Sbjct: 1580 QLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTL-QSTLDAGRCPEPPSGSPPEGPE 1638
Query: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473
+ + Q+ + E E L+++L+K+ G+ ++ + + L ++D + + + + E
Sbjct: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
Query: 474 ELRQQLEVL---EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
E L+V+ E L+ LQ Q +K E+ E+LH + E+LQ L
Sbjct: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVI---EKLQHELSL 1755
Query: 531 LEAKQSE-SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
+ E S S+ +L+ L S G + Q E+ AAL A+++++ L + + +
Sbjct: 1756 MGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAAL-EAKEALSRLLADQERRHS 1814
Query: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
+ L A +L EA L L + + E E + + SR++ E A A + +AE
Sbjct: 1815 QA--LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE 1872
Query: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
+AL ++ A+L+ A A ++ L +L R Q + Q
Sbjct: 1873 RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQ 1932
Query: 710 LEQLHQEAKR-QEEVLARAVQEKEALVR---------------------EKAALEVRLQA 747
L+ LHQ R Q E+ R + A R +A+ + L+
Sbjct: 1933 LQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEP 1992
Query: 748 VERDRQ-DLAEQLQGLSSA----KELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVTQAK 801
V D Q DL L L A +E + S L Q+Q S + + K ++ + ++ + K
Sbjct: 1993 VVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGK 2052
Query: 802 EVIQGEVRCLKLELDTERSQAEQE 825
E + + + K++L + Q +++
Sbjct: 2053 EKVLEDCQLPKVDLVAQVKQLQEK 2076
Score = 77.0 bits (188), Expect = 2e-13
Identities = 128/589 (21%), Positives = 235/589 (39%), Gaps = 83/589 (14%)
Query: 1524 LEHQLLELEKKDQMIESQRGQVQDLKKQLVTL-ECLALELEENHHKMECQQKLIKELEGQ 1582
L + E E + + +++ V+D Q++ L E LA E H + + L G
Sbjct: 2378 LPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGG 2437
Query: 1583 RETQ--------RVALTHLTLDLEERSQELQAQSSQIH----DLESHSTVLARELQERDQ 1630
+ + R L + + E+ QE+Q Q DL HS++L R
Sbjct: 2438 KTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERL------ 2491
Query: 1631 EVKSQREQIEELQRQKEHLT-QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK 1689
K REQ + ++ EHL D E+ + ++++ Q + + L L +
Sbjct: 2492 -EKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE 2550
Query: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
++ +L Q +L+ + E+ K + + +L + +K + +Q + +L+
Sbjct: 2551 ARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLK 2610
Query: 1750 -------ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802
+ +QL + L + ++V + +LS +E E+ Q+L+ EQG K ++LQ
Sbjct: 2611 SDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES--EQG--KGRALQ 2666
Query: 1803 SQLDEAQRALAQRDQE----LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
SQL+E Q QR+ + LE L+ + + Q R+ Q A + L+ H
Sbjct: 2667 SQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEH 2726
Query: 1859 GE----LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA-------------------- 1894
L + Q L+++LA E R L E L R
Sbjct: 2727 SRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQA 2786
Query: 1895 -----ESREQEKA--------LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
+ ++EK+ L +QQQ Q+ E E + ++ + + V
Sbjct: 2787 HHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKST 2846
Query: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
+EAL + + R E R + LQ L ++H L+ +E R +A
Sbjct: 2847 VEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQE---------GRKAARRSAEA 2897
Query: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQ-DLRYQEDVQQLQQALAQRDE 2049
+ S A + + + +++E E+Q Q DL + +QQ + L +DE
Sbjct: 2898 RQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDE 2946
Score = 72.8 bits (177), Expect = 4e-12
Identities = 157/699 (22%), Positives = 274/699 (39%), Gaps = 116/699 (16%)
Query: 1785 QQLQEAREQGELKEQSLQSQL----DEAQRALAQRD-----------QELEALQQEQQQA 1829
Q L EA ++ E++ + +++ L DE+ + LA + E Q+
Sbjct: 2376 QPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH 2435
Query: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL 1889
G+ + V +G L Q E+ E+Q + Q R +L ++ LE+++
Sbjct: 2436 GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKII 2495
Query: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELEALRAE 1948
R + QEK+L L+ RA L+ + LQ Q L+ L + A
Sbjct: 2496 ---REQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEAR 2552
Query: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE---ASTATLQASL 2005
HQ R + E L + + ++ L E+ E + S++ A+ T+ L
Sbjct: 2553 GSQQEHQ---LRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDL 2609
Query: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR---HQQEREQLLE 2062
+ SRQ E L E+ Q++V QL+ L+ ++ EL+ + E EQ
Sbjct: 2610 KSDLCESRQKSEQLSRSLCEV-------QQEVLQLRSMLSSKENELKAALQELESEQGKG 2662
Query: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQ-QRNN 2121
++L +++E ++ Q RE + + L + L+ AQ + + L+ Q ++N
Sbjct: 2663 RALQSQLEEEQLRHLQ-----RESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
Query: 2122 LE---ALPHSHKTSPMEEQSLKLDSLEPRLQRELER---LQAALRQTEAREIEWREKAQD 2175
L+ + HS + + ++ +L L+ L E R L ALR + ++ Q+
Sbjct: 2718 LQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE 2777
Query: 2176 ------------LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
L L + K+ V LQ + +Q L QQ+L+ E + AL
Sbjct: 2778 ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALH---SQQQLEAEAQKHCEALR 2834
Query: 2224 KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283
+E+ S ST E ++ ++ +E E EK +W Q A LE
Sbjct: 2835 REKEVSATLKSTVEALHTQKRELR----CSLERE-----REKPAWLQ---------AELE 2876
Query: 2284 IDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKN 2343
RL+ E+E RK R + A Q SP + +
Sbjct: 2877 QSHPRLK-------------EQEGRKAARRSAEARQ------------SPAAAEQWRKWQ 2911
Query: 2344 SDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPE 2403
D + + EL+ LQ Q L + ++ R ++ E+ G L + A +
Sbjct: 2912 RDKEKLRELE-----LQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGS--D 2964
Query: 2404 ATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR 2442
A L + R L E++ Q L S +L + T+QA R
Sbjct: 2965 ADHLREQQREL-EAMRQRLLSAARLL---TSFTSQAVDR 2999
Score = 55.5 bits (132), Expect = 6e-07
Identities = 114/502 (22%), Positives = 204/502 (40%), Gaps = 71/502 (14%)
Query: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA-----LLTQSQKQNEDYEKM- 305
K+++L + E QE++QL+S ++ EL+ + EL + QSQ + E +
Sbjct: 2619 KSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQ 2678
Query: 306 -----IKALRETVEILETNHTE------LMEHEASLSRNAQ---------------EEKL 339
KAL E LET + ++HE + N Q +E+
Sbjct: 2679 RESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERS 2738
Query: 340 SLQQVIKDITQVMVEEGDNIAQGSGHENSL--ELDSSIFSQFDYQDADKALTLVRSVLTR 397
L ++ KD+ + +++ HE L +L +QD L++ L
Sbjct: 2739 QLSELQKDLAAEKSRTLE-LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQK-LKE 2796
Query: 398 RRQAVQDLRQQLAGC-QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
+ V DL+ L Q+A++ QQ + ++ +ALR+ + + T+ +
Sbjct: 2797 EKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRE 2856
Query: 457 EVDSLSKERELLQKAREELRQQLEVL-EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
SL +ERE + EL Q L EQE + R + E + +A+ ++ Q+++
Sbjct: 2857 LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK 2916
Query: 516 LAVRERER---------LQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEV 566
L E +R LQ+ + LE+K S L L A ++ + + LR++Q E+
Sbjct: 2917 LRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL-HLGSARRAAGSDADHLREQQREL 2975
Query: 567 TAALARAEQSIAELSS-SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625
A R + L+S + + V D ++ NE + LL EE
Sbjct: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSS-------NEKAVM-------SLLHTLEE 3021
Query: 626 NQSVCSRMEAAEQARNA-LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
+S SR ++++ A LQ + L + N L L + EL +
Sbjct: 3022 LKSDLSRPTSSQKKMAAELQFQFV------DVLLKDNVSLTKALSTVTQEKLELSRAVSK 3075
Query: 685 IQE-EKEEIQKKLSESRHQQEA 705
+++ K +QK S SR ++ A
Sbjct: 3076 LEKLLKHHLQKGCSPSRSERSA 3097
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 207 bits (527), Expect = 1e-52
Identities = 288/1252 (23%), Positives = 556/1252 (44%), Gaps = 151/1252 (12%)
Query: 390 LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG 449
L R +R+Q + ++ C + L ++ QW ++ LQ +
Sbjct: 801 LARKAFAKRQQQLTAMKVIQRNCAAYLKL---RNWQWWRLFTKVKPLLQ--------VTR 849
Query: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN--VELQLQGDSAQGQK 507
Q ++Q + D L K +E QKA EL++ LEQ+ +L ++ QLQ ++ +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET-ELYA 904
Query: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
E ++ + LA +++E L+E+L +EA+ LE G+ L+ E+ ++
Sbjct: 905 EAEEMRVRLAAKKQE-LEEILHEMEAR--------------LEEEEDRGQQLQAERKKMA 949
Query: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
+ E+ + E ++ L+ E A K L ++L ++++N
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--------------LEDEILVMDDQNN 995
Query: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTH------LEAQLQKAEEAGAELQA 680
+ + E+ + L +LAE E++ + L + KN H LE +L+K E++ EL+
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
R ++ + + +++++ + Q QL AK++EE+ A + + + ++ A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109
Query: 741 LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
L+ +++ +E DL E L +A+ E + + +E K +LE + +
Sbjct: 1110 LK-KIRELEGHISDLQEDLDSERAARNKAEK---QKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 801 KEV---IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
+E+ + EV LK LD E E + ++ AQA +E LEQ K A + +++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDK 1224
Query: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ-REEERTQAESAL 916
++ EKE + +LA L L + K E+E + K+ + +++ +Q++ + ER +AE
Sbjct: 1225 NKQTLEKENA----DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 917 CQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA 976
+L+ E E V+ + L +A + +L +D+ + Q+T +LQ + ++
Sbjct: 1281 KVHKLQNEVESVTGM---------LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ- 1330
Query: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQE 1035
+ + RQ ++ +LQ++ ++ K +L++ + L QL D ++L + E
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL--SDSKKKLQDFASTVE 1388
Query: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
L E ++ R QKE+E +LT EK L++ + QQEL L D+
Sbjct: 1389 ALEEGKK--RFQKEIE----NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD----N 1438
Query: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Q++L + + E K+++ D L E E+ +S +++ RA A+E + L L
Sbjct: 1439 QRQLVSNL-----EKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL- 1488
Query: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215
R+ E LE A E+ +A++ L S+ +V E S
Sbjct: 1489 ARALEEALE--AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE----------KSKRA 1536
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
LE ++ + L L A A +++ K Q RD L+ + ++ EE+
Sbjct: 1537 LETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQ 1593
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
+ + + TEL+D ++Q + K K EG LE + + +LR+ + Q
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 1336 RMEAQGERELLQAAKENL--TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+ Q E E +A+++ + TA+ +A +EA L+EDL A A K +
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-----LQEDLAAAERARKQADL 1708
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
E E L E+ ++ ALQ+ L +A+ EEE+E +G ++ + +
Sbjct: 1709 EKEE-------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEK----CRSVLEHLPMAVQER-EQKLTVQRE 1508
E LS +L + Q+LE+ RS L + AV+ + + +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
+I +LE+ E + + L++KD+ ++ QV+D +K +A + +E K
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-------MAEQYKEQAEK 1874
Query: 1569 MECQQKLIKEL--EGQRETQRVALTH--LTLDLEERSQELQAQSSQIHDLES 1616
+ K +K E + E+QR+ L +L+E ++ +A +++ L+S
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 197 bits (501), Expect = 1e-49
Identities = 271/1155 (23%), Positives = 495/1155 (42%), Gaps = 158/1155 (13%)
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
L KT+E +++A +EL Q SQ EK LQ+++ + L ++++ + L
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
E + +E +E E + Q E+ + Q + D+ + + EE A+ +
Sbjct: 921 EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAARQKLQLEKV 974
Query: 370 ELDSSIFSQFD----YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE-AVNL--LQQQ 422
++ I D D + L+ R +L R + DL LA +E A NL L+ +
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEER---ISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 423 HDQW-----------EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD----SLSKEREL 467
H+ E+ + L + +KL G+ Q DLQ ++ L+K+ E
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGD---------SAQGQKEEQQEELHLA 517
LQ A L ++ ++R + + LQ D A+ QK + EEL
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ--------TEVTAA 569
E E + + +++ E+ L++AL+ E QE E+T
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
L + +++ A L ++ TL+ E ADL A +L L +A K + + +LE + Q +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQA----KQEVEHKKKKLEAQVQEL 1264
Query: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689
S+ E+AR AE + L + + L +AE +L D+ + +
Sbjct: 1265 QSKCSDGERAR-------AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
++ Q+ L E Q+ +T+L QL +E ++ L ++ K+ L R + L ++L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
+ QD A ++ L K+ + + QQ +LE + K +Q E+
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-------KTKNRLQQELD 1430
Query: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L ++LD +R Q + R+ Q E K + ++ + REK K S
Sbjct: 1431 DLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS-- 1487
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE------ERTQAESALCQMQLET 923
LA+ALE K ELE K + EME + + +++ E +++ AL + Q+E
Sbjct: 1488 ---LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-ETQMEE 1543
Query: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI--LQTQLQEAQRELK 981
K ++ LE LQ ++ +LR ++ +Q LK Q + Q +E +R+L+
Sbjct: 1544 MKTQLEELEDELQATED--------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
++ +L +++ + K L+ ++DL+ Q DS +E ++LR+ Q
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----LQADSAIKGREEAIKQLRKLQ 1651
Query: 1042 -EYNRIQKELEREKAS---LTLSLMEKEQRLLVLQEADSIR-QQELSALRQDMQEAQGEQ 1096
+ Q+ELE +AS + + E E++ L EAD ++ Q++L+A + ++A E+
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEK 1710
Query: 1097 KELSAQMELL---RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
+EL+ ++ R +++++ A+ AQL EELE E+Q + + A Q
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELE-----EEQGNMEAMSDRVRKATQQ 1765
Query: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
S E E A++ + Q + Q L S L + G+V
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV----------------- 1808
Query: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
+S FK + AL A+ +A ++ Q+ + Q L+ + +KL+E L
Sbjct: 1809 ----------KSKFK--STIAALEAK-IAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 1274 TDTEAEKSQV----------HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-- 1321
E E+ + ++ L+RQL + +EE + + L+ EL E E+
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 1322 -----MASLQSRLRR 1331
+ +L+S+LRR
Sbjct: 1916 AMGREVNALKSKLRR 1930
Score = 189 bits (480), Expect = 3e-47
Identities = 251/1184 (21%), Positives = 510/1184 (43%), Gaps = 175/1184 (14%)
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
+E ++ EL ++ Q+A+ E KEL + L +E K + L E +L E E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAE-- 907
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ-LASLYSALQ 1190
E ++R + AK +L+ L E++LE E+ G Q QA+ + +A L+
Sbjct: 908 ---EMRVRLA-----AKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 956
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+ L +R +L L ++AEA + KL
Sbjct: 957 EQLEEEEAARQKLQ----------------------------LEKVTAEA---KIKKLED 985
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDT------EAEKSQVHTELQ--------DLQRQLSQ 1296
++ + L + + LEER++D E EK++ T+L+ +L+ +L +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
++ + + E + LE + + HE +A LQ+++ AEL+ A+ E EL QAA L +
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLAKKEEEL-QAALARLDDE 1102
Query: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
+ A+ + R L+EDL + R+A ++ E +AL+ + E
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDS 1161
Query: 1417 KALQENLALLTQTLAEREEEVETLRGQIQE--------LEKQREMQKAALELLSLDLKKR 1468
A Q+ L A+RE+EV L+ + E +++ R+ A+E L+ L++
Sbjct: 1162 TATQQELR------AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 1469 NQEVDLQQEQIQELEKCRS-------VLEHLPMAVQEREQKLTVQREQIRELEKDRETQR 1521
+ + Q LEK + VL V+ +++KL Q ++++ D E R
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275
Query: 1522 ---------------------NVLEHQLLELEKKDQMIESQRGQVQDL----KKQLVTLE 1556
N E + ++L K + SQ Q+L +Q + +
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
+LEE + + Q +L +E+E ++ +R T L + L + ++LQ +S + LE
Sbjct: 1336 TKLRQLEEERNSL--QDQLDEEMEAKQNLERHIST-LNIQLSDSKKKLQDFASTVEALEE 1392
Query: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
+E++ Q+ + + ++L++ K L Q+L+ +L Q++ + LE ++ +
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 1677 QTKILEEDLEQIKLSLRER------GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
++L E+ ER RE T+ + EE + + + +K
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1512
Query: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ------ 1784
+ D + +++HEL++ K LE Q++ + ++ E L E + L+
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 1785 -----QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
+ LQ EQ E K + LQ QL E + L ++ +++ +G + ++ +
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1840 ADALQGALEQAHMTLKERHGELQDHK---EQARRLEEELAVEGR----RVQALE----EV 1888
AD+ E+A L++ +++D + E AR +E+ + + ++LE ++
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
DL A R +++A L +++ AE+ ALQD + +A + + ++ELE +
Sbjct: 1693 QEDLAAAERARKQADLE-KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008
++ + A +AE L L + Q E ++
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNE---------------------SARQQL 1790
Query: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ- 2067
+ +++L L EG ++ +++ + L+ +AQ +E++ + +Q KSL Q
Sbjct: 1791 ERQNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 2068 --RVQENMIQ--EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE 2123
+++E ++Q +++ + ++ +E+ +G + V++L+ L + E+E + +++ E
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 2124 ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI 2167
T E ++++L+ +L+R E R++ R +
Sbjct: 1907 L---DEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1947
Score = 183 bits (464), Expect = 2e-45
Identities = 267/1151 (23%), Positives = 509/1151 (44%), Gaps = 155/1151 (13%)
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
++ T+++ L + Q +E ++K E EL + E ++ L+ E + +
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAK--------EDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
E+ LLQ E LQA E A+A E++R +A K + EE+ E E
Sbjct: 888 EKNLLQ----------EQLQAET-ELYAEA-------EEMRVRLAAKKQELEEILHEMEA 929
Query: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
L+E+ + +G+ LQ + Q + + EE++E E++ QK LE +
Sbjct: 930 R--LEEEED----RGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLEKV 974
Query: 1462 SLD--LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET 1519
+ + +KK E+ + +Q +L K R +LE ER LT + E K+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLE-------ERISDLTTNLAEEEEKAKNLTK 1027
Query: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK-E 1578
+N E + ELE + + E R +++ LK++L E A + E ++ Q +K +
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKL---EGDASDFHEQIADLQAQIAELKMQ 1084
Query: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE----RDQEVKS 1634
L + E + AL L ++ +++ L+ +I +LE H + L +L R++ K
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1635 QREQIEELQRQKEHL--TQDLERRDQELMLQKER-IQVLEDQRTRQTKILEEDLEQIKLS 1691
+R+ EEL+ K L T D QEL ++E+ + VL+ +T+ E +++++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 1692 LRERGRELTTQ-RQLMQERA--EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH-E 1747
+ ELT Q Q + +A ++ K + + L +L ++EVE +++ + +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1748 LQELKD----------QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
+QEL+ +L ++ L +V + +L++ E + + L + + Q
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ---- 1316
Query: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Q Q L E R +L L++E+ Q Q + E L+ + ++ L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEH 1917
+LQD LEE + ++ L + + A + EK LQQ+ + +
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD- 1435
Query: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQ--SSRHQEEAARARAEALQEALGKAHA 1975
D+ Q + L+++ ++ + L AE + SS++ +E RA AEA +E KA +
Sbjct: 1436 -------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALS 1487
Query: 1976 ALQGKEQHLLEQAELSRS---LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
+ E+ L + EL R+ L+A L +S D + +LE++ R E ++++ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 2033 YQEDVQQLQQALAQRDEELRHQQEREQL---LEKSLAQRVQENMIQEKQ----------N 2079
+E +LQ A D +LR + + L E+ L R ++N + +Q
Sbjct: 1548 LEELEDELQ---ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 2080 LGQEREEEEI-----RGLHQSVRELQL----TLAQKEQEILELRETQQR-----NNLEAL 2125
L ER++ + + L +++L+L + +E+ I +LR+ Q + LE
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 2126 PHSHKT--SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
S + +E K SLE L + E L AA R + ++E E A++LA SL+
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELEL----TRRALEK-ERLHSPGAT--STA 2236
A LQ+ L+A + + + E + Q +E R+A ++ E+L + AT STA
Sbjct: 1725 NA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 2237 ELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR-------- 2288
+ Q ++ +G K ++ + L+ +A+LE +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 2289 ---LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSD 2345
L++ + +L+ L QVE E RK+ + A+ G+ + + ++ + N++
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 2346 AKCVAELQKEV 2356
+ +LQ+E+
Sbjct: 1900 RR---KLQREL 1907
Score = 159 bits (401), Expect = 4e-38
Identities = 210/1033 (20%), Positives = 455/1033 (44%), Gaps = 106/1033 (10%)
Query: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK--KRNQEVDLQQEQIQELEKCRS 1487
+ +EEE++ ++Q+ ++++ QKA EL L+ K + +E +L QEQ+Q + +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQ--QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1488 VLEHLPMAVQEREQKLTV---QREQIRELEKDR----ETQRNVLEHQLLELEKKDQMIES 1540
E + + + ++Q+L + E E E+DR + +R + Q+L+LE++ +E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ---LEE 961
Query: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
+ Q L+ + VT E +LE+ M+ Q +L +R+ ++ LT +L E
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEE 1018
Query: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
++ + + L++ + EL+ R ++ + R+++E+L+R+ E D + +L
Sbjct: 1019 EEK----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE--EGKGPSK 1718
Q I L+ Q ++ + L+ L ++ + ++ L R+L ++ E +
Sbjct: 1075 QAQ---IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
A R E K RD +E+E + EL++ D Q + ++ E ++L ++
Sbjct: 1132 AARNKAEKQK---RDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ--------------ELEALQQ 1824
E + Q+QE R++ + L QL++ +RA A D+ EL L Q
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 1825 EQQQAQGQEERVKEKADALQGAL---EQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
+Q+ + ++++++ + LQ E+A L ++ +LQ+ E + E EG+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKA 1303
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQ---CAEQAQEHEVETRALQDSWLQAQAVLKER 1938
++ ++V L ++ ++ ++ L +Q + + ++ E E +LQD + +
Sbjct: 1304 IKLAKDV-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
++ + L + S+ + + + EAL+E + ++ Q E+A LE +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1999 ATLQASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-ELRHQ 2054
LQ LD + RQL L ++ + DQ L ++++ R E E R +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
+ + L ++L + ++ E+ N + E E++ V + + +K + LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQ 1540
Query: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLD----SLEPRLQREL--------ERLQAALRQT 2162
+ + LE L + E+ L+L+ +L+ + +R+L E+ + RQ
Sbjct: 1541 MEEMKTQLEEL--EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD---SEQQRLQDELELTR 2219
E E ++ + AL+ A K L+++ + +++ R+ + ++LQ +++ +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLG------EVSGVEAEPSPDGMEKQSWRQRLE 2273
R LE R +TA+ + + ++ +++ E +EK+ + L
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK---REAMRAAQAGSLEISKATA 2330
L+ ++ RL+ QL LE+ + + R+A + A+ S E++ +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 2331 SSPTQQDGRGQ-------------------KNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
++ + R Q K+ +A L+ ++ L+ Q+ E ++KQ
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 2372 DYITRSAQTSREL 2384
Q ++L
Sbjct: 1839 AATKSLKQKDKKL 1851
Score = 155 bits (392), Expect = 5e-37
Identities = 242/1170 (20%), Positives = 488/1170 (41%), Gaps = 125/1170 (10%)
Query: 28 QQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQR 87
+QQ AEN+ + K+SQ +++ L +LQA+ Y +E+ RL A Q
Sbjct: 867 RQQKAENELKELEQ-KHSQLTEEKNL-LQEQLQAETELYAE-AEEMRVRLAAK----KQE 919
Query: 88 WENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSR 147
E + L E+ RLEEE+ R + L ++ M D+ + E+ + + +
Sbjct: 920 LEEI----LHEMEARLEEEEDRGQQLQAERKKMAQQM--LDLEEQLEEEEAARQKLQLEK 973
Query: 148 ARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD----RDLM 203
E K+ +E E + + LS R+++ R L A + ++L
Sbjct: 974 VTAEAKIKK----LEDEIL---VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 204 ELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHER 263
+LK +H + L +RL +SR+ L ++LE +A +
Sbjct: 1027 KLKNKHESMISELE---VRLKKEEKSRQE----------------LEKLKRKLEGDASDF 1067
Query: 264 SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
+++ L++Q K +L + EL A L + + +K +RE LE + ++L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE----LEGHISDL 1123
Query: 324 MEH---EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
E E + A+++K L + ++ + + + D+ A E + ++ +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
++ V+ + + QAV++L +QL + A L + E+E L L+ L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE----- 495
+ + + L+ +V L + ++AR EL ++ L+ E + + E
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 496 LQLQGD--SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
++L D S Q ++ QE L R++ + L LE +++ +L EA ++
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
L + ++ L ++ L + + E+ +L + +A + L K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 614 GLNQQL--LQLEEENQ-SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
L Q+L L ++ +NQ + S +E ++ + L LAE + ++ EA+ ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYADERDRAEAEARE 1480
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
E L L + E KEE+ E L+ ++ ++ + + V E
Sbjct: 1481 KETKALSLARALEEALEAKEEL-----------ERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
E + K ALE +++ ++ ++L ++LQ AK LE ++ + KGQ
Sbjct: 1530 LE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM----------QALKGQF 1576
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
E +Q + E + +++ E +TE ++R AA AA
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA------------------AA 1618
Query: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
+K L K+ K E ++ +L+ ++K+ Q E+E +A R+E
Sbjct: 1619 KKKLEGDL-----KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGIL- 969
A+ E EK+ SL L+Q Q++LA A + R + D++ ++L E+ + +
Sbjct: 1674 TAK--------ENEKKAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAEELASSLSG 1723
Query: 970 QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029
+ LQ+ +R L+ Q ++L Q ++ +Q E L ++L + + +
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 1030 EQEVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
E Q+ R+ +E E+E K+ ++ E ++ L+E +E A +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 1089 MQEAQGEQKELSAQME---LLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQ 1145
+++ + KE+ Q+E + ++ KE+ A+ QL +LE + Q++ A+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 1146 EAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175
+ + + + ++ AL ++ + GN+
Sbjct: 1904 QRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 103 bits (257), Expect = 2e-21
Identities = 189/935 (20%), Positives = 354/935 (37%), Gaps = 207/935 (22%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
+++ N + Q L E + L + + + A+ ++L+ +E Q L + L
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALD 1184
Query: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVE--EPNLDELLVRLEEEQQRCESLAEVNT 118
+ + + QE+ ++ + ++ E + + NLD+ LE+E V
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Q + +E +A ++++ D RAR EL K + Q E E G L G+ +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
L ++V + S+ +D EL E R
Sbjct: 1305 KLAKDVASL--------SSQLQDTQELLQEETR--------------------------- 1329
Query: 239 DGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE-KAELQDRVTELSALLTQSQK 297
Q L + K ++LE+E + +L + ++E K L+ ++ L+ L+ S+K
Sbjct: 1330 ------QKLNVSTKLRQLEEERNSLQDQLDE-----EMEAKQNLERHISTLNIQLSDSKK 1378
Query: 298 QNEDYEKMIKALRETVEILET---NHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354
+ +D+ ++AL E + + N T+ E +A+ ++ K LQQ + D+ +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 355 EGD---NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
+ N+ + + L + S + D+A R T+ + L + L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKA 471
+E E K L+ ++ L +D D+ V L K + L+
Sbjct: 1499 KEEL-----------ERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSKRALETQ 1540
Query: 472 REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ-------KEEQQEE--------LH- 515
EE++ QLE LE E + L++ + +GQ ++EQ EE LH
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 516 -------------LAVRERERLQEMLMGLEAK-------QSESLSELITLREALESSHLE 555
LA +++L+ L LE + + E++ +L L+ ++ E
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA---------------AVK 600
E R + E+ A E+ L + L+ ++A A A
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA-----------AEQARNALQVDLAE 649
LS N AL +K L ++ QLEEE + MEA AEQ N L + +
Sbjct: 1721 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 650 AEKR---REALWEKNTHL----------------------EAQLQKAEEAGAELQADLRD 684
A+K R+ L +N L EA++ + EE
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE----------- 1828
Query: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR 744
++ + +++AAT + L Q+ K+ +E+L + E++ + K
Sbjct: 1829 ----------QVEQEAREKQAAT---KSLKQKDKKLKEILLQVEDERKMAEQYK------ 1869
Query: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
EQ + ++ + L+ L EA++++ I + +L+ ++ T++ E +
Sbjct: 1870 ------------EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 805 QGEVRCLKLEL--DTERSQAEQERDAAARQLAQAE 837
EV LK +L E S R R + A+
Sbjct: 1918 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1952
Score = 78.2 bits (191), Expect = 9e-14
Identities = 120/560 (21%), Positives = 246/560 (43%), Gaps = 60/560 (10%)
Query: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
A+ ++Q A+ +Q+ CA + + L V ++ ++E++A E Q ++
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-EEEMQAKEDELQKTK 865
Query: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
+++ A + L++ H+ L ++ L EQ + L A ++ L A +
Sbjct: 866 ERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAEEMRVRL---AAKKQ 918
Query: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL------LEKSLAQ 2067
+LEE L E +++++ R Q+ +Q ++ +AQ+ +L Q E E+ LEK A+
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQ-LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 2068 RV-------------QENMIQEKQNLGQER---------EEEE-------IRGLHQS-VR 2097
Q N + +++ L +ER EEEE ++ H+S +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
EL++ L ++E+ EL + +++ +A + + ++ Q + L+ +L ++ E LQA
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---IAELKMQLAKKEEELQA 1094
Query: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
AL + + EI + A + + + +S LQE +A+ + + +++ L +ELE
Sbjct: 1095 ALARLDD-EIAQKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
+ LE + L S + EL ++ EQ V + + ++ E + Q RQ+ Q
Sbjct: 1151 LKTELE-DTLDS--TATQQELRAKREQEVTVLK-KALDEETRSHEAQVQEMRQKHA---Q 1203
Query: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
AV L + +R L + +E+E L E QA K Q+
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 2338 GRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL-L 2396
+ + + + AEL +V LQ ++ + ++ + ++++A L L + L
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 2397 AVAQAPEATVLEAETRRLDE 2416
+ + + + R+L+E
Sbjct: 1324 LQEETRQKLNVSTKLRQLEE 1343
Score = 48.5 bits (114), Expect = 8e-05
Identities = 83/368 (22%), Positives = 147/368 (39%), Gaps = 49/368 (13%)
Query: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPMEEQSLKLDSLE 2145
+++ L Q R+ + + KE E+ + +E QQ+ N L+ L H + EE++L L+
Sbjct: 840 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNL----LQ 893
Query: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
+LQ E E A E + K Q+L L + +A + ++ LQA +
Sbjct: 894 EQLQAETELYAEA----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949
Query: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
+ L+++LE A +K +L T+ A++ + E+ ++ + + E+
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEK--VTAEAKIKKLED------EILVMDDQNNKLSKER 1001
Query: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE----------RERRKLKRE-- 2313
+ +R+ L +A E L + + S + ++E +E KLKR+
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 2314 ----------AMRAAQAGSLEISKATASSPTQ------QDGRGQKNSDAKCVAELQKEVV 2357
A AQ L++ A Q D QKN+ K + EL+ +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 2358 LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV-LEAETRRLDE 2416
LQ L ER + + EL L L +L + A E E E L +
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 2417 SLTQSLTS 2424
+L + S
Sbjct: 1182 ALDEETRS 1189
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 207 bits (527), Expect = 1e-52
Identities = 288/1252 (23%), Positives = 556/1252 (44%), Gaps = 151/1252 (12%)
Query: 390 LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG 449
L R +R+Q + ++ C + L ++ QW ++ LQ +
Sbjct: 808 LARKAFAKRQQQLTAMKVIQRNCAAYLKL---RNWQWWRLFTKVKPLLQ--------VTR 856
Query: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN--VELQLQGDSAQGQK 507
Q ++Q + D L K +E QKA EL++ LEQ+ +L ++ QLQ ++ +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET-ELYA 911
Query: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
E ++ + LA +++E L+E+L +EA+ LE G+ L+ E+ ++
Sbjct: 912 EAEEMRVRLAAKKQE-LEEILHEMEAR--------------LEEEEDRGQQLQAERKKMA 956
Query: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
+ E+ + E ++ L+ E A K L ++L ++++N
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--------------LEDEILVMDDQNN 1002
Query: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTH------LEAQLQKAEEAGAELQA 680
+ + E+ + L +LAE E++ + L + KN H LE +L+K E++ EL+
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
R ++ + + +++++ + Q QL AK++EE+ A + + + ++ A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116
Query: 741 LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
L+ +++ +E DL E L +A+ E + + +E K +LE + +
Sbjct: 1117 LK-KIRELEGHISDLQEDLDSERAARNKAEK---QKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 801 KEV---IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
+E+ + EV LK LD E E + ++ AQA +E LEQ K A + +++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDK 1231
Query: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ-REEERTQAESAL 916
++ EKE + +LA L L + K E+E + K+ + +++ +Q++ + ER +AE
Sbjct: 1232 NKQTLEKENA----DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 917 CQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA 976
+L+ E E V+ + L +A + +L +D+ + Q+T +LQ + ++
Sbjct: 1288 KVHKLQNEVESVTGM---------LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ- 1337
Query: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQE 1035
+ + RQ ++ +LQ++ ++ K +L++ + L QL D ++L + E
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL--SDSKKKLQDFASTVE 1395
Query: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
L E ++ R QKE+E +LT EK L++ + QQEL L D+
Sbjct: 1396 ALEEGKK--RFQKEIE----NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD----N 1445
Query: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Q++L + + E K+++ D L E E+ +S +++ RA A+E + L L
Sbjct: 1446 QRQLVSNL-----EKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL- 1495
Query: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215
R+ E LE A E+ +A++ L S+ +V E S
Sbjct: 1496 ARALEEALE--AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE----------KSKRA 1543
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
LE ++ + L L A A +++ K Q RD L+ + ++ EE+
Sbjct: 1544 LETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQ 1600
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
+ + + TEL+D ++Q + K K EG LE + + +LR+ + Q
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 1336 RMEAQGERELLQAAKENL--TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+ Q E E +A+++ + TA+ +A +EA L+EDL A A K +
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-----LQEDLAAAERARKQADL 1715
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
E E L E+ ++ ALQ+ L +A+ EEE+E +G ++ + +
Sbjct: 1716 EKEE-------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEK----CRSVLEHLPMAVQER-EQKLTVQRE 1508
E LS +L + Q+LE+ RS L + AV+ + + +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
+I +LE+ E + + L++KD+ ++ QV+D +K +A + +E K
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-------MAEQYKEQAEK 1881
Query: 1569 MECQQKLIKEL--EGQRETQRVALTH--LTLDLEERSQELQAQSSQIHDLES 1616
+ K +K E + E+QR+ L +L+E ++ +A +++ L+S
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 197 bits (501), Expect = 1e-49
Identities = 271/1155 (23%), Positives = 495/1155 (42%), Gaps = 158/1155 (13%)
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
L KT+E +++A +EL Q SQ EK LQ+++ + L ++++ + L
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
E + +E +E E + Q E+ + Q + D+ + + EE A+ +
Sbjct: 928 EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAARQKLQLEKV 981
Query: 370 ELDSSIFSQFD----YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE-AVNL--LQQQ 422
++ I D D + L+ R +L R + DL LA +E A NL L+ +
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEER---ISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 423 HDQW-----------EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD----SLSKEREL 467
H+ E+ + L + +KL G+ Q DLQ ++ L+K+ E
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGD---------SAQGQKEEQQEELHLA 517
LQ A L ++ ++R + + LQ D A+ QK + EEL
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ--------TEVTAA 569
E E + + +++ E+ L++AL+ E QE E+T
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
L + +++ A L ++ TL+ E ADL A +L L +A K + + +LE + Q +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQA----KQEVEHKKKKLEAQVQEL 1271
Query: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689
S+ E+AR AE + L + + L +AE +L D+ + +
Sbjct: 1272 QSKCSDGERAR-------AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
++ Q+ L E Q+ +T+L QL +E ++ L ++ K+ L R + L ++L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
+ QD A ++ L K+ + + QQ +LE + K +Q E+
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-------KTKNRLQQELD 1437
Query: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L ++LD +R Q + R+ Q E K + ++ + REK K S
Sbjct: 1438 DLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS-- 1494
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE------ERTQAESALCQMQLET 923
LA+ALE K ELE K + EME + + +++ E +++ AL + Q+E
Sbjct: 1495 ---LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-ETQMEE 1550
Query: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI--LQTQLQEAQRELK 981
K ++ LE LQ ++ +LR ++ +Q LK Q + Q +E +R+L+
Sbjct: 1551 MKTQLEELEDELQATED--------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
++ +L +++ + K L+ ++DL+ Q DS +E ++LR+ Q
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----LQADSAIKGREEAIKQLRKLQ 1658
Query: 1042 -EYNRIQKELEREKAS---LTLSLMEKEQRLLVLQEADSIR-QQELSALRQDMQEAQGEQ 1096
+ Q+ELE +AS + + E E++ L EAD ++ Q++L+A + ++A E+
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEK 1717
Query: 1097 KELSAQMELL---RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
+EL+ ++ R +++++ A+ AQL EELE E+Q + + A Q
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELE-----EEQGNMEAMSDRVRKATQQ 1772
Query: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
S E E A++ + Q + Q L S L + G+V
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV----------------- 1815
Query: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
+S FK + AL A+ +A ++ Q+ + Q L+ + +KL+E L
Sbjct: 1816 ----------KSKFK--STIAALEAK-IAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 1274 TDTEAEKSQV----------HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-- 1321
E E+ + ++ L+RQL + +EE + + L+ EL E E+
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 1322 -----MASLQSRLRR 1331
+ +L+S+LRR
Sbjct: 1923 AMGREVNALKSKLRR 1937
Score = 189 bits (480), Expect = 3e-47
Identities = 251/1184 (21%), Positives = 510/1184 (43%), Gaps = 175/1184 (14%)
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
+E ++ EL ++ Q+A+ E KEL + L +E K + L E +L E E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAE-- 914
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ-LASLYSALQ 1190
E ++R + AK +L+ L E++LE E+ G Q QA+ + +A L+
Sbjct: 915 ---EMRVRLA-----AKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 963
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+ L +R +L L ++AEA + KL
Sbjct: 964 EQLEEEEAARQKLQ----------------------------LEKVTAEA---KIKKLED 992
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDT------EAEKSQVHTELQ--------DLQRQLSQ 1296
++ + L + + LEER++D E EK++ T+L+ +L+ +L +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
++ + + E + LE + + HE +A LQ+++ AEL+ A+ E EL QAA L +
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLAKKEEEL-QAALARLDDE 1109
Query: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
+ A+ + R L+EDL + R+A ++ E +AL+ + E
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDS 1168
Query: 1417 KALQENLALLTQTLAEREEEVETLRGQIQE--------LEKQREMQKAALELLSLDLKKR 1468
A Q+ L A+RE+EV L+ + E +++ R+ A+E L+ L++
Sbjct: 1169 TATQQELR------AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 1469 NQEVDLQQEQIQELEKCRS-------VLEHLPMAVQEREQKLTVQREQIRELEKDRETQR 1521
+ + Q LEK + VL V+ +++KL Q ++++ D E R
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282
Query: 1522 ---------------------NVLEHQLLELEKKDQMIESQRGQVQDL----KKQLVTLE 1556
N E + ++L K + SQ Q+L +Q + +
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
+LEE + + Q +L +E+E ++ +R T L + L + ++LQ +S + LE
Sbjct: 1343 TKLRQLEEERNSL--QDQLDEEMEAKQNLERHIST-LNIQLSDSKKKLQDFASTVEALEE 1399
Query: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
+E++ Q+ + + ++L++ K L Q+L+ +L Q++ + LE ++ +
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 1677 QTKILEEDLEQIKLSLRER------GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
++L E+ ER RE T+ + EE + + + +K
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519
Query: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ------ 1784
+ D + +++HEL++ K LE Q++ + ++ E L E + L+
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 1785 -----QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
+ LQ EQ E K + LQ QL E + L ++ +++ +G + ++ +
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1840 ADALQGALEQAHMTLKERHGELQDHK---EQARRLEEELAVEGR----RVQALE----EV 1888
AD+ E+A L++ +++D + E AR +E+ + + ++LE ++
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
DL A R +++A L +++ AE+ ALQD + +A + + ++ELE +
Sbjct: 1700 QEDLAAAERARKQADLE-KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008
++ + A +AE L L + Q E ++
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNE---------------------SARQQL 1797
Query: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ- 2067
+ +++L L EG ++ +++ + L+ +AQ +E++ + +Q KSL Q
Sbjct: 1798 ERQNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 2068 --RVQENMIQ--EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLE 2123
+++E ++Q +++ + ++ +E+ +G + V++L+ L + E+E + +++ E
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 2124 ALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI 2167
T E ++++L+ +L+R E R++ R +
Sbjct: 1914 L---DEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRV 1954
Score = 183 bits (464), Expect = 2e-45
Identities = 267/1151 (23%), Positives = 509/1151 (44%), Gaps = 155/1151 (13%)
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
++ T+++ L + Q +E ++K E EL + E ++ L+ E + +
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAK--------EDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
E+ LLQ E LQA E A+A E++R +A K + EE+ E E
Sbjct: 895 EKNLLQ----------EQLQAET-ELYAEA-------EEMRVRLAAKKQELEEILHEMEA 936
Query: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
L+E+ + +G+ LQ + Q + + EE++E E++ QK LE +
Sbjct: 937 R--LEEEED----RGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLEKV 981
Query: 1462 SLD--LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET 1519
+ + +KK E+ + +Q +L K R +LE ER LT + E K+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLE-------ERISDLTTNLAEEEEKAKNLTK 1034
Query: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK-E 1578
+N E + ELE + + E R +++ LK++L E A + E ++ Q +K +
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKL---EGDASDFHEQIADLQAQIAELKMQ 1091
Query: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE----RDQEVKS 1634
L + E + AL L ++ +++ L+ +I +LE H + L +L R++ K
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1635 QREQIEELQRQKEHL--TQDLERRDQELMLQKER-IQVLEDQRTRQTKILEEDLEQIKLS 1691
+R+ EEL+ K L T D QEL ++E+ + VL+ +T+ E +++++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 1692 LRERGRELTTQ-RQLMQERA--EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH-E 1747
+ ELT Q Q + +A ++ K + + L +L ++EVE +++ + +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1748 LQELKD----------QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
+QEL+ +L ++ L +V + +L++ E + + L + + Q
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ---- 1323
Query: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Q Q L E R +L L++E+ Q Q + E L+ + ++ L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEH 1917
+LQD LEE + ++ L + + A + EK LQQ+ + +
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD- 1442
Query: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQ--SSRHQEEAARARAEALQEALGKAHA 1975
D+ Q + L+++ ++ + L AE + SS++ +E RA AEA +E KA +
Sbjct: 1443 -------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALS 1494
Query: 1976 ALQGKEQHLLEQAELSRS---LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
+ E+ L + EL R+ L+A L +S D + +LE++ R E ++++ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 2033 YQEDVQQLQQALAQRDEELRHQQEREQL---LEKSLAQRVQENMIQEKQ----------N 2079
+E +LQ A D +LR + + L E+ L R ++N + +Q
Sbjct: 1555 LEELEDELQ---ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 2080 LGQEREEEEI-----RGLHQSVRELQL----TLAQKEQEILELRETQQR-----NNLEAL 2125
L ER++ + + L +++L+L + +E+ I +LR+ Q + LE
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 2126 PHSHKT--SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
S + +E K SLE L + E L AA R + ++E E A++LA SL+
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELEL----TRRALEK-ERLHSPGAT--STA 2236
A LQ+ L+A + + + E + Q +E R+A ++ E+L + AT STA
Sbjct: 1732 NA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 2237 ELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR-------- 2288
+ Q ++ +G K ++ + L+ +A+LE +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 2289 ---LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSD 2345
L++ + +L+ L QVE E RK+ + A+ G+ + + ++ + N++
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 2346 AKCVAELQKEV 2356
+ +LQ+E+
Sbjct: 1907 RR---KLQREL 1914
Score = 159 bits (401), Expect = 4e-38
Identities = 210/1033 (20%), Positives = 455/1033 (44%), Gaps = 106/1033 (10%)
Query: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK--KRNQEVDLQQEQIQELEKCRS 1487
+ +EEE++ ++Q+ ++++ QKA EL L+ K + +E +L QEQ+Q + +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQ--QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1488 VLEHLPMAVQEREQKLTV---QREQIRELEKDR----ETQRNVLEHQLLELEKKDQMIES 1540
E + + + ++Q+L + E E E+DR + +R + Q+L+LE++ +E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ---LEE 968
Query: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
+ Q L+ + VT E +LE+ M+ Q +L +R+ ++ LT +L E
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEE 1025
Query: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
++ + + L++ + EL+ R ++ + R+++E+L+R+ E D + +L
Sbjct: 1026 EEK----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE--EGKGPSK 1718
Q I L+ Q ++ + L+ L ++ + ++ L R+L ++ E +
Sbjct: 1082 QAQ---IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
A R E K RD +E+E + EL++ D Q + ++ E ++L ++
Sbjct: 1139 AARNKAEKQK---RDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ--------------ELEALQQ 1824
E + Q+QE R++ + L QL++ +RA A D+ EL L Q
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 1825 EQQQAQGQEERVKEKADALQGAL---EQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
+Q+ + ++++++ + LQ E+A L ++ +LQ+ E + E EG+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKA 1310
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQ---CAEQAQEHEVETRALQDSWLQAQAVLKER 1938
++ ++V L ++ ++ ++ L +Q + + ++ E E +LQD + +
Sbjct: 1311 IKLAKDV-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
++ + L + S+ + + + EAL+E + ++ Q E+A LE +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1999 ATLQASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-ELRHQ 2054
LQ LD + RQL L ++ + DQ L ++++ R E E R +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
+ + L ++L + ++ E+ N + E E++ V + + +K + LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQ 1547
Query: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLD----SLEPRLQREL--------ERLQAALRQT 2162
+ + LE L + E+ L+L+ +L+ + +R+L E+ + RQ
Sbjct: 1548 MEEMKTQLEEL--EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD---SEQQRLQDELELTR 2219
E E ++ + AL+ A K L+++ + +++ R+ + ++LQ +++ +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLG------EVSGVEAEPSPDGMEKQSWRQRLE 2273
R LE R +TA+ + + ++ +++ E +EK+ + L
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK---REAMRAAQAGSLEISKATA 2330
L+ ++ RL+ QL LE+ + + R+A + A+ S E++ +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 2331 SSPTQQDGRGQ-------------------KNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
++ + R Q K+ +A L+ ++ L+ Q+ E ++KQ
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 2372 DYITRSAQTSREL 2384
Q ++L
Sbjct: 1846 AATKSLKQKDKKL 1858
Score = 155 bits (392), Expect = 5e-37
Identities = 242/1170 (20%), Positives = 488/1170 (41%), Gaps = 125/1170 (10%)
Query: 28 QQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQR 87
+QQ AEN+ + K+SQ +++ L +LQA+ Y +E+ RL A Q
Sbjct: 874 RQQKAENELKELEQ-KHSQLTEEKNL-LQEQLQAETELYAE-AEEMRVRLAAK----KQE 926
Query: 88 WENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSR 147
E + L E+ RLEEE+ R + L ++ M D+ + E+ + + +
Sbjct: 927 LEEI----LHEMEARLEEEEDRGQQLQAERKKMAQQM--LDLEEQLEEEEAARQKLQLEK 980
Query: 148 ARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD----RDLM 203
E K+ +E E + + LS R+++ R L A + ++L
Sbjct: 981 VTAEAKIKK----LEDEIL---VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 204 ELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHER 263
+LK +H + L +RL +SR+ L ++LE +A +
Sbjct: 1034 KLKNKHESMISELE---VRLKKEEKSRQE----------------LEKLKRKLEGDASDF 1074
Query: 264 SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
+++ L++Q K +L + EL A L + + +K +RE LE + ++L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE----LEGHISDL 1130
Query: 324 MEH---EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
E E + A+++K L + ++ + + + D+ A E + ++ +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
++ V+ + + QAV++L +QL + A L + E+E L L+ L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE----- 495
+ + + L+ +V L + ++AR EL ++ L+ E + + E
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 496 LQLQGD--SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
++L D S Q ++ QE L R++ + L LE +++ +L EA ++
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
L + ++ L ++ L + + E+ +L + +A + L K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 614 GLNQQL--LQLEEENQ-SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
L Q+L L ++ +NQ + S +E ++ + L LAE + ++ EA+ ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYADERDRAEAEARE 1487
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
E L L + E KEE+ E L+ ++ ++ + + V E
Sbjct: 1488 KETKALSLARALEEALEAKEEL-----------ERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
E + K ALE +++ ++ ++L ++LQ AK LE ++ + KGQ
Sbjct: 1537 LE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM----------QALKGQF 1583
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
E +Q + E + +++ E +TE ++R AA AA
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA------------------AA 1625
Query: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
+K L K+ K E ++ +L+ ++K+ Q E+E +A R+E
Sbjct: 1626 KKKLEGDL-----KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGIL- 969
A+ E EK+ SL L+Q Q++LA A + R + D++ ++L E+ + +
Sbjct: 1681 TAK--------ENEKKAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAEELASSLSG 1730
Query: 970 QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029
+ LQ+ +R L+ Q ++L Q ++ +Q E L ++L + + +
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 1030 EQEVQEKLRETQEYNRIQKELE-REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
E Q+ R+ +E E+E K+ ++ E ++ L+E +E A +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 1089 MQEAQGEQKELSAQME---LLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQ 1145
+++ + KE+ Q+E + ++ KE+ A+ QL +LE + Q++ A+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 1146 EAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175
+ + + + ++ AL ++ + GN+
Sbjct: 1911 QRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 103 bits (257), Expect = 2e-21
Identities = 189/935 (20%), Positives = 354/935 (37%), Gaps = 207/935 (22%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
+++ N + Q L E + L + + + A+ ++L+ +E Q L + L
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALD 1191
Query: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVE--EPNLDELLVRLEEEQQRCESLAEVNT 118
+ + + QE+ ++ + ++ E + + NLD+ LE+E V
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Q + +E +A ++++ D RAR EL K + Q E E G L G+ +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
L ++V + S+ +D EL E R
Sbjct: 1312 KLAKDVASL--------SSQLQDTQELLQEETR--------------------------- 1336
Query: 239 DGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE-KAELQDRVTELSALLTQSQK 297
Q L + K ++LE+E + +L + ++E K L+ ++ L+ L+ S+K
Sbjct: 1337 ------QKLNVSTKLRQLEEERNSLQDQLDE-----EMEAKQNLERHISTLNIQLSDSKK 1385
Query: 298 QNEDYEKMIKALRETVEILET---NHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354
+ +D+ ++AL E + + N T+ E +A+ ++ K LQQ + D+ +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 355 EGD---NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
+ N+ + + L + S + D+A R T+ + L + L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKA 471
+E E K L+ ++ L +D D+ V L K + L+
Sbjct: 1506 KEEL-----------ERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSKRALETQ 1547
Query: 472 REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ-------KEEQQEE--------LH- 515
EE++ QLE LE E + L++ + +GQ ++EQ EE LH
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 516 -------------LAVRERERLQEMLMGLEAK-------QSESLSELITLREALESSHLE 555
LA +++L+ L LE + + E++ +L L+ ++ E
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA---------------AVK 600
E R + E+ A E+ L + L+ ++A A A
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA-----------AEQARNALQVDLAE 649
LS N AL +K L ++ QLEEE + MEA AEQ N L + +
Sbjct: 1728 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 650 AEKR---REALWEKNTHL----------------------EAQLQKAEEAGAELQADLRD 684
A+K R+ L +N L EA++ + EE
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE----------- 1835
Query: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR 744
++ + +++AAT + L Q+ K+ +E+L + E++ + K
Sbjct: 1836 ----------QVEQEAREKQAAT---KSLKQKDKKLKEILLQVEDERKMAEQYK------ 1876
Query: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
EQ + ++ + L+ L EA++++ I + +L+ ++ T++ E +
Sbjct: 1877 ------------EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 805 QGEVRCLKLEL--DTERSQAEQERDAAARQLAQAE 837
EV LK +L E S R R + A+
Sbjct: 1925 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1959
Score = 78.2 bits (191), Expect = 9e-14
Identities = 120/560 (21%), Positives = 246/560 (43%), Gaps = 60/560 (10%)
Query: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
A+ ++Q A+ +Q+ CA + + L V ++ ++E++A E Q ++
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-EEEMQAKEDELQKTK 872
Query: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
+++ A + L++ H+ L ++ L EQ + L A ++ L A +
Sbjct: 873 ERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAEEMRVRL---AAKKQ 925
Query: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL------LEKSLAQ 2067
+LEE L E +++++ R Q+ +Q ++ +AQ+ +L Q E E+ LEK A+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQ-LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 2068 RV-------------QENMIQEKQNLGQER---------EEEE-------IRGLHQS-VR 2097
Q N + +++ L +ER EEEE ++ H+S +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
EL++ L ++E+ EL + +++ +A + + ++ Q + L+ +L ++ E LQA
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---IAELKMQLAKKEEELQA 1101
Query: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
AL + + EI + A + + + +S LQE +A+ + + +++ L +ELE
Sbjct: 1102 ALARLDD-EIAQKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
+ LE + L S + EL ++ EQ V + + ++ E + Q RQ+ Q
Sbjct: 1158 LKTELE-DTLDS--TATQQELRAKREQEVTVLK-KALDEETRSHEAQVQEMRQKHA---Q 1210
Query: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
AV L + +R L + +E+E L E QA K Q+
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 2338 GRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL-L 2396
+ + + + AEL +V LQ ++ + ++ + ++++A L L + L
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 2397 AVAQAPEATVLEAETRRLDE 2416
+ + + + R+L+E
Sbjct: 1331 LQEETRQKLNVSTKLRQLEE 1350
Score = 48.5 bits (114), Expect = 8e-05
Identities = 83/368 (22%), Positives = 147/368 (39%), Gaps = 49/368 (13%)
Query: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPMEEQSLKLDSLE 2145
+++ L Q R+ + + KE E+ + +E QQ+ N L+ L H + EE++L L+
Sbjct: 847 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNL----LQ 900
Query: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
+LQ E E A E + K Q+L L + +A + ++ LQA +
Sbjct: 901 EQLQAETELYAEA----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956
Query: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
+ L+++LE A +K +L T+ A++ + E+ ++ + + E+
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEK--VTAEAKIKKLED------EILVMDDQNNKLSKER 1008
Query: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE----------RERRKLKRE-- 2313
+ +R+ L +A E L + + S + ++E +E KLKR+
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 2314 ----------AMRAAQAGSLEISKATASSPTQ------QDGRGQKNSDAKCVAELQKEVV 2357
A AQ L++ A Q D QKN+ K + EL+ +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 2358 LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV-LEAETRRLDE 2416
LQ L ER + + EL L L +L + A E E E L +
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 2417 SLTQSLTS 2424
+L + S
Sbjct: 1189 ALDEETRS 1196
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 207 bits (527), Expect = 1e-52
Identities = 288/1252 (23%), Positives = 556/1252 (44%), Gaps = 151/1252 (12%)
Query: 390 LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG 449
L R +R+Q + ++ C + L ++ QW ++ LQ +
Sbjct: 808 LARKAFAKRQQQLTAMKVIQRNCAAYLKL---RNWQWWRLFTKVKPLLQ--------VTR 856
Query: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN--VELQLQGDSAQGQK 507
Q ++Q + D L K +E QKA EL++ LEQ+ +L ++ QLQ ++ +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET-ELYA 911
Query: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
E ++ + LA +++E L+E+L +EA+ LE G+ L+ E+ ++
Sbjct: 912 EAEEMRVRLAAKKQE-LEEILHEMEAR--------------LEEEEDRGQQLQAERKKMA 956
Query: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
+ E+ + E ++ L+ E A K L ++L ++++N
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--------------LEDEILVMDDQNN 1002
Query: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTH------LEAQLQKAEEAGAELQA 680
+ + E+ + L +LAE E++ + L + KN H LE +L+K E++ EL+
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
R ++ + + +++++ + Q QL AK++EE+ A + + + ++ A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116
Query: 741 LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
L+ +++ +E DL E L +A+ E + + +E K +LE + +
Sbjct: 1117 LK-KIRELEGHISDLQEDLDSERAARNKAEK---QKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 801 KEV---IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
+E+ + EV LK LD E E + ++ AQA +E LEQ K A + +++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDK 1231
Query: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ-REEERTQAESAL 916
++ EKE + +LA L L + K E+E + K+ + +++ +Q++ + ER +AE
Sbjct: 1232 NKQTLEKENA----DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 917 CQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA 976
+L+ E E V+ + L +A + +L +D+ + Q+T +LQ + ++
Sbjct: 1288 KVHKLQNEVESVTGM---------LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ- 1337
Query: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQE 1035
+ + RQ ++ +LQ++ ++ K +L++ + L QL D ++L + E
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL--SDSKKKLQDFASTVE 1395
Query: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
L E ++ R QKE+E +LT EK L++ + QQEL L D+
Sbjct: 1396 ALEEGKK--RFQKEIE----NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD----N 1445
Query: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Q++L + + E K+++ D L E E+ +S +++ RA A+E + L L
Sbjct: 1446 QRQLVSNL-----EKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL- 1495
Query: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215
R+ E LE A E+ +A++ L S+ +V E S
Sbjct: 1496 ARALEEALE--AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE----------KSKRA 1543
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
LE ++ + L L A A +++ K Q RD L+ + ++ EE+
Sbjct: 1544 LETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQ 1600
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
+ + + TEL+D ++Q + K K EG LE + + +LR+ + Q
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 1336 RMEAQGERELLQAAKENL--TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+ Q E E +A+++ + TA+ +A +EA L+EDL A A K +
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-----LQEDLAAAERARKQADL 1715
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
E E L E+ ++ ALQ+ L +A+ EEE+E +G ++ + +
Sbjct: 1716 EKEE-------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEK----CRSVLEHLPMAVQER-EQKLTVQRE 1508
E LS +L + Q+LE+ RS L + AV+ + + +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
+I +LE+ E + + L++KD+ ++ QV+D +K +A + +E K
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-------MAEQYKEQAEK 1881
Query: 1569 MECQQKLIKEL--EGQRETQRVALTH--LTLDLEERSQELQAQSSQIHDLES 1616
+ K +K E + E+QR+ L +L+E ++ +A +++ L+S
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 203 bits (516), Expect = 2e-51
Identities = 280/1240 (22%), Positives = 553/1240 (44%), Gaps = 169/1240 (13%)
Query: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538
L++ + WRL V+ LQ + + + +++EL +++ + L LE K S+
Sbjct: 834 LKLRNWQWWRLF-TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL 892
Query: 539 LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598
E L+E L++ T A AE+ L++ + L+ + ++ A
Sbjct: 893 TEEKNLLQEQLQAE--------------TELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 599 VKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALW 658
+ + L ++ + QQ+L LEE+ +E E AR LQ++ AE + + L
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQ-------LEEEEAARQKLQLEKVTAEAKIKKLE 991
Query: 659 EKNTHLEAQ---LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE-QLH 714
++ ++ Q L K + E +DL E+EE K L++ +++ E+ ++LE +L
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 715 QEAKRQEEV--LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
+E K ++E+ L R ++ + E+ A +++ Q E Q LA++ + L +A L+
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQ-LAKKEEELQAALARLDDE 1109
Query: 773 LFEAQQQNSVIEVTK-----GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827
+ AQ+ N++ ++ + L+ + + A+ + + R L EL+ +++ E D
Sbjct: 1110 I--AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 828 AAARQL---AQAEQEG---KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
+ A Q A+ EQE K AL+++ +HE +V ++R+K + +EL + LE +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA----VEELTEQLEQFK 1223
Query: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
R K L+ K +QT EKE L L + L
Sbjct: 1224 RAKANLD---KNKQT--------------------------LEKENADLAGEL----RVL 1250
Query: 942 ADASQQLERLRQDMK--VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999
A Q++E ++ ++ VQ+L+ + + G + A+ EL + + ++++ ++ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDG------ERARAELNDKVHKLQNEVESVTGMLN 1304
Query: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
+ L K V L SQL D+Q L+++E ++KL + + ++LE E+ SL
Sbjct: 1305 EAEGKAIKLAKDVASLSSQL---QDTQELLQEETRQKLNVSTKL----RQLEEERNSLQD 1357
Query: 1060 SL---MEKEQRL------LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
L ME +Q L L +Q +DS +++L ++ + +K ++E L Q+
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 1111 KEKEADFLAQEA------QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
+EK A + E Q L++L ++QL ++L ++ K QL + E +
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL----AEEKNIS 1471
Query: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
+ A+++ +A+A+ + S L +AL E++ EL
Sbjct: 1472 SKYADERDRAEAEAREKETKALS-LARALEEALEAKEELER-----------------TN 1513
Query: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
+ K S + V +H+L + + + ++ Q+++LE+ L TE K ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
+Q L+ Q ++ + + + QN E LQ +L E + + + +R
Sbjct: 1574 VNMQALKGQFERDLQARDE----QNE---------EKRRQLQRQLHEYETELEDERKQRA 1620
Query: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILE--EDLRTARSALKLKNEEVESERERA 1402
L AAK+ L ++ L E +A ++ G E + LR ++ +K E+E R
Sbjct: 1621 LAAAAKKKLEGDLKDL-----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675
Query: 1403 QALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462
+ + + K+L+ +L L + LA E + + +++ E E+ + +
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNA 1733
Query: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRET-Q 1520
L +KR E + Q + +ELE+ + +E A+ +R +K T Q EQ+ EL +R T Q
Sbjct: 1734 LQDEKRRLEARIAQLE-EELEEEQGNME----AMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 1521 RNVLEHQLLELEKKD--QMIESQRGQVQD-LKKQLVTLECLALELEENHHKMECQQKLIK 1577
+N Q LE + K+ + G V+ K + LE +LEE + +++
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
+ Q++ + L + L +E+ + + Q + L R+L+E ++E +
Sbjct: 1849 KSLKQKDKK---LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677
+LQR+ + T+ E +E+ K +++ Q T Q
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945
Score = 199 bits (505), Expect = 4e-50
Identities = 263/1172 (22%), Positives = 515/1172 (43%), Gaps = 174/1172 (14%)
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
+E ++ EL ++ Q+A+ E KEL + L +E K + L E +L E E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAE-- 914
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ-LASLYSALQ 1190
E ++R + AK +L+ L E++LE E+ G Q QA+ + +A L+
Sbjct: 915 ---EMRVRLA-----AKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 963
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+ L +R +L L ++AEA + KL
Sbjct: 964 EQLEEEEAARQKLQ----------------------------LEKVTAEA---KIKKLED 992
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDT------EAEKSQVHTELQ--------DLQRQLSQ 1296
++ + L + + LEER++D E EK++ T+L+ +L+ +L +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
++ + + E + LE + + HE +A LQ+++ AEL+ A+ E EL QAA L +
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLAKKEEEL-QAALARLDDE 1109
Query: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
+ A+ + R L+EDL + R+A ++ E +AL+ + E
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDS 1168
Query: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
A Q+ L A+RE+EV L+ + E + E Q + +K Q V+
Sbjct: 1169 TATQQELR------AKREQEVTVLKKALDEETRSHEAQVQEMR------QKHAQAVEELT 1216
Query: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK-- 1534
EQ+++ ++ ++ L+ +++ L + + + +++ E ++ LE Q+ EL+ K
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 1535 ---------DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRET 1585
+ + + +V+ + L E A++L ++ + Q + +EL +
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 1586 QRVALTHLTLDLEERSQELQAQSSQI----HDLESHSTVLARELQERDQEVKSQREQIEE 1641
Q++ ++ LEE LQ Q + +LE H + L +L + ++++ +E
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
L+ K+ +++E Q+ + LE + R L+++L+ + + L + R+L +
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----LQQELDDLVVDL-DNQRQLVS 1451
Query: 1702 -----QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE 1756
QR+ Q AEE K S + + R+KE + + E E K++LE
Sbjct: 1452 NLEKKQRKFDQLLAEE-KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510
Query: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
+ T+ +L +++V + + + + E +++L++Q++E + L + +
Sbjct: 1511 R-----------TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 1817 QELEALQQEQQQAQGQEERVKEKADA-LQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875
EL+A + + + + + +K + + LQ EQ ++ +L +++ + LE+E
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE---LEDER 1616
Query: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
A +++ GDL+ L LQ A + +E ++ Q LQAQ +
Sbjct: 1617 KQRALAAAAKKKLEGDLKD---------LELQADSAIKGREEAIK----QLRKLQAQ--M 1661
Query: 1936 KERDQELEALRAESQ----SSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
K+ +ELE RA +++ E+ A++ L + AA + ++Q LE+ EL+
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 1992 RSLEASTA---TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ------ 2042
L +S + LQ +A QLEE L ++G ++ R ++ QQ +Q
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 2043 ---ALAQRDEELRHQQERE------QLLE---------KSLAQRVQENMIQEKQNLGQER 2084
+ AQ++E R Q ER+ +L E KS ++ + Q ++ + QE
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 2085 EEEEI--RGLHQSVRELQLTLAQKEQE---ILELRETQQRNNLEALPHSHKTSPMEEQSL 2139
E++ + L Q ++L+ L Q E E + +E ++ N + EE+S
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 2140 KLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171
++++ +LQREL+ TE+ E RE
Sbjct: 1902 RINANRRKLQRELD------EATESNEAMGRE 1927
Score = 195 bits (496), Expect = 4e-49
Identities = 270/1154 (23%), Positives = 494/1154 (42%), Gaps = 158/1154 (13%)
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
L KT+E +++A +EL Q SQ EK LQ+++ + L ++++ + L
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
E + +E +E E + Q E+ + Q + D+ + + EE A+ +
Sbjct: 928 EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAARQKLQLEKV 981
Query: 370 ELDSSIFSQFD----YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE-AVNL--LQQQ 422
++ I D D + L+ R +L R + DL LA +E A NL L+ +
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEER---ISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 423 HDQW-----------EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD----SLSKEREL 467
H+ E+ + L + +KL G+ Q DLQ ++ L+K+ E
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGD---------SAQGQKEEQQEELHLA 517
LQ A L ++ ++R + + LQ D A+ QK + EEL
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ--------TEVTAA 569
E E + + +++ E+ L++AL+ E QE E+T
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
L + +++ A L ++ TL+ E ADL A +L L +A K + + +LE + Q +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQA----KQEVEHKKKKLEAQVQEL 1271
Query: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689
S+ E+AR AE + L + + L +AE +L D+ + +
Sbjct: 1272 QSKCSDGERAR-------AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
++ Q+ L E Q+ +T+L QL +E ++ L ++ K+ L R + L ++L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
+ QD A ++ L K+ + + QQ +LE + K +Q E+
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-------KTKNRLQQELD 1437
Query: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L ++LD +R Q + R+ Q E K + ++ + REK K S
Sbjct: 1438 DLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS-- 1494
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE------ERTQAESALCQMQLET 923
LA+ALE K ELE K + EME + + +++ E +++ AL + Q+E
Sbjct: 1495 ---LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-ETQMEE 1550
Query: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI--LQTQLQEAQRELK 981
K ++ LE LQ ++ +LR ++ +Q LK Q + Q +E +R+L+
Sbjct: 1551 MKTQLEELEDELQATED--------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
++ +L +++ + K L+ ++DL+ Q DS +E ++LR+ Q
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----LQADSAIKGREEAIKQLRKLQ 1658
Query: 1042 -EYNRIQKELEREKAS---LTLSLMEKEQRLLVLQEADSIR-QQELSALRQDMQEAQGEQ 1096
+ Q+ELE +AS + + E E++ L EAD ++ Q++L+A + ++A E+
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEK 1717
Query: 1097 KELSAQMELL---RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
+EL+ ++ R +++++ A+ AQL EELE E+Q + + A Q
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELE-----EEQGNMEAMSDRVRKATQQ 1772
Query: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
S E E A++ + Q + Q L S L + G+V
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV----------------- 1815
Query: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
+S FK + AL A+ +A ++ Q+ + Q L+ + +KL+E L
Sbjct: 1816 ----------KSKFK--STIAALEAK-IAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862
Query: 1274 TDTEAEKSQV----------HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-- 1321
E E+ + ++ L+RQL + +EE + + L+ EL E E+
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 1322 -----MASLQSRLR 1330
+ +L+S+LR
Sbjct: 1923 AMGREVNALKSKLR 1936
Score = 183 bits (464), Expect = 2e-45
Identities = 267/1151 (23%), Positives = 509/1151 (44%), Gaps = 155/1151 (13%)
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
++ T+++ L + Q +E ++K E EL + E ++ L+ E + +
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAK--------EDELQKTKERQQKAENELKELEQKHSQLTE 894
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
E+ LLQ E LQA E A+A E++R +A K + EE+ E E
Sbjct: 895 EKNLLQ----------EQLQAET-ELYAEA-------EEMRVRLAAKKQELEEILHEMEA 936
Query: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
L+E+ + +G+ LQ + Q + + EE++E E++ QK LE +
Sbjct: 937 R--LEEEED----RGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLEKV 981
Query: 1462 SLD--LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET 1519
+ + +KK E+ + +Q +L K R +LE ER LT + E K+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLE-------ERISDLTTNLAEEEEKAKNLTK 1034
Query: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK-E 1578
+N E + ELE + + E R +++ LK++L E A + E ++ Q +K +
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKL---EGDASDFHEQIADLQAQIAELKMQ 1091
Query: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE----RDQEVKS 1634
L + E + AL L ++ +++ L+ +I +LE H + L +L R++ K
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1635 QREQIEELQRQKEHL--TQDLERRDQELMLQKER-IQVLEDQRTRQTKILEEDLEQIKLS 1691
+R+ EEL+ K L T D QEL ++E+ + VL+ +T+ E +++++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 1692 LRERGRELTTQ-RQLMQERA--EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH-E 1747
+ ELT Q Q + +A ++ K + + L +L ++EVE +++ + +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 1748 LQELKD----------QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
+QEL+ +L ++ L +V + +L++ E + + L + + Q
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ---- 1323
Query: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Q Q L E R +L L++E+ Q Q + E L+ + ++ L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEH 1917
+LQD LEE + ++ L + + A + EK LQQ+ + +
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD- 1442
Query: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQ--SSRHQEEAARARAEALQEALGKAHA 1975
D+ Q + L+++ ++ + L AE + SS++ +E RA AEA +E KA +
Sbjct: 1443 -------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALS 1494
Query: 1976 ALQGKEQHLLEQAELSRS---LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
+ E+ L + EL R+ L+A L +S D + +LE++ R E ++++ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 2033 YQEDVQQLQQALAQRDEELRHQQEREQL---LEKSLAQRVQENMIQEKQ----------N 2079
+E +LQ A D +LR + + L E+ L R ++N + +Q
Sbjct: 1555 LEELEDELQ---ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 2080 LGQEREEEEI-----RGLHQSVRELQL----TLAQKEQEILELRETQQR-----NNLEAL 2125
L ER++ + + L +++L+L + +E+ I +LR+ Q + LE
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 2126 PHSHKT--SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
S + +E K SLE L + E L AA R + ++E E A++LA SL+
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELEL----TRRALEK-ERLHSPGAT--STA 2236
A LQ+ L+A + + + E + Q +E R+A ++ E+L + AT STA
Sbjct: 1732 NA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 2237 ELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR-------- 2288
+ Q ++ +G K ++ + L+ +A+LE +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 2289 ---LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSD 2345
L++ + +L+ L QVE E RK+ + A+ G+ + + ++ + N++
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 2346 AKCVAELQKEV 2356
+ +LQ+E+
Sbjct: 1907 RR---KLQREL 1914
Score = 159 bits (401), Expect = 4e-38
Identities = 210/1033 (20%), Positives = 455/1033 (44%), Gaps = 106/1033 (10%)
Query: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK--KRNQEVDLQQEQIQELEKCRS 1487
+ +EEE++ ++Q+ ++++ QKA EL L+ K + +E +L QEQ+Q + +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQ--QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 1488 VLEHLPMAVQEREQKLTV---QREQIRELEKDR----ETQRNVLEHQLLELEKKDQMIES 1540
E + + + ++Q+L + E E E+DR + +R + Q+L+LE++ +E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ---LEE 968
Query: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
+ Q L+ + VT E +LE+ M+ Q +L +R+ ++ LT +L E
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEE 1025
Query: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
++ + + L++ + EL+ R ++ + R+++E+L+R+ E D + +L
Sbjct: 1026 EEK----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE--EGKGPSK 1718
Q I L+ Q ++ + L+ L ++ + ++ L R+L ++ E +
Sbjct: 1082 QAQ---IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
A R E K RD +E+E + EL++ D Q + ++ E ++L ++
Sbjct: 1139 AARNKAEKQK---RDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ--------------ELEALQQ 1824
E + Q+QE R++ + L QL++ +RA A D+ EL L Q
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 1825 EQQQAQGQEERVKEKADALQGAL---EQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
+Q+ + ++++++ + LQ E+A L ++ +LQ+ E + E EG+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKA 1310
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQ---CAEQAQEHEVETRALQDSWLQAQAVLKER 1938
++ ++V L ++ ++ ++ L +Q + + ++ E E +LQD + +
Sbjct: 1311 IKLAKDV-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
++ + L + S+ + + + EAL+E + ++ Q E+A LE +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 1999 ATLQASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-ELRHQ 2054
LQ LD + RQL L ++ + DQ L ++++ R E E R +
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
+ + L ++L + ++ E+ N + E E++ V + + +K + LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQ 1547
Query: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLD----SLEPRLQREL--------ERLQAALRQT 2162
+ + LE L + E+ L+L+ +L+ + +R+L E+ + RQ
Sbjct: 1548 MEEMKTQLEEL--EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD---SEQQRLQDELELTR 2219
E E ++ + AL+ A K L+++ + +++ R+ + ++LQ +++ +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLG------EVSGVEAEPSPDGMEKQSWRQRLE 2273
R LE R +TA+ + + ++ +++ E +EK+ + L
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK---REAMRAAQAGSLEISKATA 2330
L+ ++ RL+ QL LE+ + + R+A + A+ S E++ +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 2331 SSPTQQDGRGQ-------------------KNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
++ + R Q K+ +A L+ ++ L+ Q+ E ++KQ
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 2372 DYITRSAQTSREL 2384
Q ++L
Sbjct: 1846 AATKSLKQKDKKL 1858
Score = 154 bits (390), Expect = 8e-37
Identities = 227/1119 (20%), Positives = 477/1119 (42%), Gaps = 110/1119 (9%)
Query: 28 QQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQR 87
+QQ AEN+ + K+SQ +++ L +LQA+ Y +E+ RL A Q
Sbjct: 874 RQQKAENELKELEQ-KHSQLTEEKNL-LQEQLQAETELYAE-AEEMRVRLAAK----KQE 926
Query: 88 WENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSR 147
E + L E+ RLEEE+ R + L ++ M D+ + E+ + + +
Sbjct: 927 LEEI----LHEMEARLEEEEDRGQQLQAERKKMAQQM--LDLEEQLEEEEAARQKLQLEK 980
Query: 148 ARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD----RDLM 203
E K+ +E E + + LS R+++ R L A + ++L
Sbjct: 981 VTAEAKIKK----LEDEIL---VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 204 ELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHER 263
+LK +H + L +RL +SR+ L ++LE +A +
Sbjct: 1034 KLKNKHESMISELE---VRLKKEEKSRQE----------------LEKLKRKLEGDASDF 1074
Query: 264 SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
+++ L++Q K +L + EL A L + + +K +RE LE + ++L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE----LEGHISDL 1130
Query: 324 MEH---EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
E E + A+++K L + ++ + + + D+ A E + ++ +
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
++ V+ + + QAV++L +QL + A L + E+E L L+ L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE----- 495
+ + + L+ +V L + ++AR EL ++ L+ E + + E
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 496 LQLQGD--SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
++L D S Q ++ QE L R++ + L LE +++ +L EA ++
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
L + ++ L ++ L + + E+ +L + +A + L K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 614 GLNQQL--LQLEEENQ-SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
L Q+L L ++ +NQ + S +E ++ + L LAE + ++ EA+ ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYADERDRAEAEARE 1487
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
E L L + E KEE+ E L+ ++ ++ + + V E
Sbjct: 1488 KETKALSLARALEEALEAKEEL-----------ERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
E + K ALE +++ ++ ++L ++LQ AK LE ++ + KGQ
Sbjct: 1537 LE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM----------QALKGQF 1583
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
E +Q + E + +++ E +TE ++R AA + E + K Q +A
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 851 ---HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA---Q 904
E+ + QLR+ + + + ++ LE + E+ KE + + ++++A Q
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
+E+ AE A Q LE E E L + L + L D ++LE ++ + +EQ
Sbjct: 1699 LQEDLAAAERARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS---LLQDKMDLQKQVEDL------ 1015
+ ++++A ++ ++ + + + + Q+ S+ L + +L+ ++ ++
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 1016 --KSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073
KS + A + +E++V+++ RE Q + K+ +++ + L + ++ + +E
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 1074 ADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE 1112
+ L++ ++EA+ E + ++A L++E+ E
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 84.7 bits (208), Expect = 1e-15
Identities = 162/816 (19%), Positives = 314/816 (38%), Gaps = 158/816 (19%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
+++ N + Q L E + L + + + A+ ++L+ +E Q L + L
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALD 1191
Query: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVE--EPNLDELLVRLEEEQQRCESLAEVNT 118
+ + + QE+ ++ + ++ E + + NLD+ LE+E V
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Q + +E +A ++++ D RAR EL K + Q E E G L G+ +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
L ++V + S+ +D EL E R ++ T +L S + M
Sbjct: 1312 KLAKDVASL--------SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 239 DGREPAQL---------------LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQD 283
+ ++ + L A T E +E +R Q+ I+ +Q EKA D
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 284 RVT--------ELSALLTQSQKQNEDYEKMIKALRETVEIL------ETNHTELMEHEAS 329
++ EL L+ Q + + K R+ ++L + + + + +
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 330 LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY----QDAD 385
+R + + LSL + +++ + E + + E++ + S+ D + +
Sbjct: 1484 EAREKETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538
Query: 386 KALTLVRSVLTRRRQAVQDLRQQLAGCQEA-----VNL----------LQQQHDQWEEEG 430
K+ + + + + +++L +L ++A VN+ LQ + +Q EE+
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 431 KALRQRLQKLTGE--------------RDTLAGQTVDLQGEVDSLSKERELLQKAREELR 476
+ L+++L + E + L G DL+ + DS K RE K +L+
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 477 QQLEVLEQEAWRLRRVNVEL-------------------QLQGDSAQGQ---------KE 508
Q++ ++E R E+ QLQ D A + KE
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 509 EQQEELHLAVRERERLQEMLMGLEAK---------------------------QSESLS- 540
E EEL ++ R LQ+ LEA+ Q+E LS
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSI-AELSSSENTLKTEVADLRAA-- 597
EL T R + + + L ++ E+ + L E ++ ++ S+ L+ ++A L
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 598 --AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE 655
A + A ++L L + LLQ+E+E + E AE+ ++
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----------- 1887
Query: 656 ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
L+ QL++AEE + A+ R +Q E +E
Sbjct: 1888 -------QLKRQLEEAEEESQRINANRRKLQRELDE 1916
Score = 78.2 bits (191), Expect = 9e-14
Identities = 120/560 (21%), Positives = 246/560 (43%), Gaps = 60/560 (10%)
Query: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
A+ ++Q A+ +Q+ CA + + L V ++ ++E++A E Q ++
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-EEEMQAKEDELQKTK 872
Query: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
+++ A + L++ H+ L ++ L EQ + L A ++ L A +
Sbjct: 873 ERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAEEMRVRL---AAKKQ 925
Query: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL------LEKSLAQ 2067
+LEE L E +++++ R Q+ +Q ++ +AQ+ +L Q E E+ LEK A+
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQ-LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 2068 RV-------------QENMIQEKQNLGQER---------EEEE-------IRGLHQS-VR 2097
Q N + +++ L +ER EEEE ++ H+S +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
EL++ L ++E+ EL + +++ +A + + ++ Q + L+ +L ++ E LQA
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---IAELKMQLAKKEEELQA 1101
Query: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
AL + + EI + A + + + +S LQE +A+ + + +++ L +ELE
Sbjct: 1102 ALARLDD-EIAQKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
+ LE + L S + EL ++ EQ V + + ++ E + Q RQ+ Q
Sbjct: 1158 LKTELE-DTLDS--TATQQELRAKREQEVTVLK-KALDEETRSHEAQVQEMRQKHA---Q 1210
Query: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
AV L + +R L + +E+E L E QA K Q+
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 2338 GRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL-L 2396
+ + + + AEL +V LQ ++ + ++ + ++++A L L + L
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 2397 AVAQAPEATVLEAETRRLDE 2416
+ + + + R+L+E
Sbjct: 1331 LQEETRQKLNVSTKLRQLEE 1350
Score = 63.9 bits (154), Expect = 2e-09
Identities = 125/588 (21%), Positives = 235/588 (39%), Gaps = 98/588 (16%)
Query: 20 LEEQVLALQQQMAENQAASWR----------KLKNSQEAQQRQATLVRKLQAKVLQYRSW 69
LEE+ +LQ Q+ E A +L +S++ Q A+ V L+ +++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 70 CQELEKRLEATGGPIP--QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL------- 120
+ L ++ E ++ +N + LD+L+V L+ ++Q +L + +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 121 -RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLS 179
+ + AD ++A E EK T S AR E++ ++E+ LK E L+S
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT--NKMLKAEMEDLVS 1525
Query: 180 LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLT---CCLRLTVGAQSREPNGSG 236
+V + K A + + E+K + L L LRL V Q+ +
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 237 RMDGREPAQLLLLLAKTQELEKEAHERSQEL------------IQLKSQGDLEKAELQ-- 282
+ R+ K ++L+++ HE EL + K +GDL+ ELQ
Sbjct: 1586 DLQARDEQNE----EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 283 ----------DRVTELSALLTQSQKQNEDY--------------EKMIKALRETVEILET 318
++ +L A + Q++ ED EK K+L + L+
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 319 N--------------HTELMEHEASL--SRNA-QEEKLSLQQVIKDITQVMVEEGDNI-- 359
+ EL E AS RNA Q+EK L+ I + + + EE N+
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 360 -----------AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD-LRQ 407
A+ +E + E ++ ++ Q ++ +RS L AV+ +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL 467
+A + + L++Q +Q E +A + L++ + + Q D + + ++ E
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
++L++QLE E+E+ R+ +LQ + D A E E++
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 48.5 bits (114), Expect = 8e-05
Identities = 83/368 (22%), Positives = 147/368 (39%), Gaps = 49/368 (13%)
Query: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPMEEQSLKLDSLE 2145
+++ L Q R+ + + KE E+ + +E QQ+ N L+ L H + EE++L L+
Sbjct: 847 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNL----LQ 900
Query: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
+LQ E E A E + K Q+L L + +A + ++ LQA +
Sbjct: 901 EQLQAETELYAEA----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956
Query: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
+ L+++LE A +K +L T+ A++ + E+ ++ + + E+
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEK--VTAEAKIKKLED------EILVMDDQNNKLSKER 1008
Query: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE----------RERRKLKRE-- 2313
+ +R+ L +A E L + + S + ++E +E KLKR+
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 2314 ----------AMRAAQAGSLEISKATASSPTQ------QDGRGQKNSDAKCVAELQKEVV 2357
A AQ L++ A Q D QKN+ K + EL+ +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 2358 LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV-LEAETRRLDE 2416
LQ L ER + + EL L L +L + A E E E L +
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 2417 SLTQSLTS 2424
+L + S
Sbjct: 1189 ALDEETRS 1196
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 207 bits (527), Expect = 1e-52
Identities = 288/1252 (23%), Positives = 556/1252 (44%), Gaps = 151/1252 (12%)
Query: 390 LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG 449
L R +R+Q + ++ C + L ++ QW ++ LQ +
Sbjct: 801 LARKAFAKRQQQLTAMKVIQRNCAAYLKL---RNWQWWRLFTKVKPLLQ--------VTR 849
Query: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVN--VELQLQGDSAQGQK 507
Q ++Q + D L K +E QKA EL++ LEQ+ +L ++ QLQ ++ +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET-ELYA 904
Query: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
E ++ + LA +++E L+E+L +EA+ LE G+ L+ E+ ++
Sbjct: 905 EAEEMRVRLAAKKQE-LEEILHEMEAR--------------LEEEEDRGQQLQAERKKMA 949
Query: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
+ E+ + E ++ L+ E A K L ++L ++++N
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--------------LEDEILVMDDQNN 995
Query: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWE-KNTH------LEAQLQKAEEAGAELQA 680
+ + E+ + L +LAE E++ + L + KN H LE +L+K E++ EL+
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
R ++ + + +++++ + Q QL AK++EE+ A + + + ++ A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109
Query: 741 LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
L+ +++ +E DL E L +A+ E + + +E K +LE + +
Sbjct: 1110 LK-KIRELEGHISDLQEDLDSERAARNKAEK---QKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 801 KEV---IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
+E+ + EV LK LD E E + ++ AQA +E LEQ K A + +++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDK 1224
Query: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ-REEERTQAESAL 916
++ EKE + +LA L L + K E+E + K+ + +++ +Q++ + ER +AE
Sbjct: 1225 NKQTLEKENA----DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 917 CQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA 976
+L+ E E V+ + L +A + +L +D+ + Q+T +LQ + ++
Sbjct: 1281 KVHKLQNEVESVTGM---------LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ- 1330
Query: 977 QRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE-QEVQE 1035
+ + RQ ++ +LQ++ ++ K +L++ + L QL D ++L + E
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL--SDSKKKLQDFASTVE 1388
Query: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
L E ++ R QKE+E +LT EK L++ + QQEL L D+
Sbjct: 1389 ALEEGKK--RFQKEIE----NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD----N 1438
Query: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR 1155
Q++L + + E K+++ D L E E+ +S +++ RA A+E + L L
Sbjct: 1439 QRQLVSNL-----EKKQRKFDQLLAE----EKNISSKYADERDRAEAEAREKETKALSL- 1488
Query: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215
R+ E LE A E+ +A++ L S+ +V E S
Sbjct: 1489 ARALEEALE--AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE----------KSKRA 1536
Query: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
LE ++ + L L A A +++ K Q RD L+ + ++ EE+
Sbjct: 1537 LETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERD-LQARDEQNEEKRRQ 1593
Query: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335
+ + + TEL+D ++Q + K K EG LE + + +LR+ + Q
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 1336 RMEAQGERELLQAAKENL--TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
+ Q E E +A+++ + TA+ +A +EA L+EDL A A K +
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ-----LQEDLAAAERARKQADL 1708
Query: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
E E L E+ ++ ALQ+ L +A+ EEE+E +G ++ + +
Sbjct: 1709 EKEE-------LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEK----CRSVLEHLPMAVQER-EQKLTVQRE 1508
E LS +L + Q+LE+ RS L + AV+ + + +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
+I +LE+ E + + L++KD+ ++ QV+D +K +A + +E K
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-------MAEQYKEQAEK 1874
Query: 1569 MECQQKLIKEL--EGQRETQRVALTH--LTLDLEERSQELQAQSSQIHDLES 1616
+ K +K E + E+QR+ L +L+E ++ +A +++ L+S
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 203 bits (516), Expect = 2e-51
Identities = 280/1240 (22%), Positives = 553/1240 (44%), Gaps = 169/1240 (13%)
Query: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538
L++ + WRL V+ LQ + + + +++EL +++ + L LE K S+
Sbjct: 827 LKLRNWQWWRLF-TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL 885
Query: 539 LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598
E L+E L++ T A AE+ L++ + L+ + ++ A
Sbjct: 886 TEEKNLLQEQLQAE--------------TELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 599 VKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALW 658
+ + L ++ + QQ+L LEE+ +E E AR LQ++ AE + + L
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQ-------LEEEEAARQKLQLEKVTAEAKIKKLE 984
Query: 659 EKNTHLEAQ---LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE-QLH 714
++ ++ Q L K + E +DL E+EE K L++ +++ E+ ++LE +L
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 715 QEAKRQEEV--LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
+E K ++E+ L R ++ + E+ A +++ Q E Q LA++ + L +A L+
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQ-LAKKEEELQAALARLDDE 1102
Query: 773 LFEAQQQNSVIEVTK-----GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827
+ AQ+ N++ ++ + L+ + + A+ + + R L EL+ +++ E D
Sbjct: 1103 I--AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 828 AAARQL---AQAEQEG---KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE 881
+ A Q A+ EQE K AL+++ +HE +V ++R+K + +EL + LE +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA----VEELTEQLEQFK 1216
Query: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKEL 941
R K L+ K +QT EKE L L + L
Sbjct: 1217 RAKANLD---KNKQT--------------------------LEKENADLAGEL----RVL 1243
Query: 942 ADASQQLERLRQDMK--VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999
A Q++E ++ ++ VQ+L+ + + G + A+ EL + + ++++ ++ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDG------ERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
+ L K V L SQL D+Q L+++E ++KL + + ++LE E+ SL
Sbjct: 1298 EAEGKAIKLAKDVASLSSQL---QDTQELLQEETRQKLNVSTKL----RQLEEERNSLQD 1350
Query: 1060 SL---MEKEQRL------LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
L ME +Q L L +Q +DS +++L ++ + +K ++E L Q+
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDS--KKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 1111 KEKEADFLAQEA------QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
+EK A + E Q L++L ++QL ++L ++ K QL + E +
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL----AEEKNIS 1464
Query: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
+ A+++ +A+A+ + S L +AL E++ EL
Sbjct: 1465 SKYADERDRAEAEAREKETKALS-LARALEEALEAKEELER-----------------TN 1506
Query: 1225 SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284
+ K S + V +H+L + + + ++ Q+++LE+ L TE K ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
+Q L+ Q ++ + + + QN E LQ +L E + + + +R
Sbjct: 1567 VNMQALKGQFERDLQARDE----QNE---------EKRRQLQRQLHEYETELEDERKQRA 1613
Query: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILE--EDLRTARSALKLKNEEVESERERA 1402
L AAK+ L ++ L E +A ++ G E + LR ++ +K E+E R
Sbjct: 1614 LAAAAKKKLEGDLKDL-----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668
Query: 1403 QALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462
+ + + K+L+ +L L + LA E + + +++ E E+ + +
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNA 1726
Query: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRET-Q 1520
L +KR E + Q + +ELE+ + +E A+ +R +K T Q EQ+ EL +R T Q
Sbjct: 1727 LQDEKRRLEARIAQLE-EELEEEQGNME----AMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 1521 RNVLEHQLLELEKKD--QMIESQRGQVQD-LKKQLVTLECLALELEENHHKMECQQKLIK 1577
+N Q LE + K+ + G V+ K + LE +LEE + +++
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
+ Q++ + L + L +E+ + + Q + L R+L+E ++E +
Sbjct: 1842 KSLKQKDKK---LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677
+LQR+ + T+ E +E+ K +++ Q T Q
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938
Score = 199 bits (505), Expect = 4e-50
Identities = 263/1172 (22%), Positives = 515/1172 (43%), Gaps = 174/1172 (14%)
Query: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
+E ++ EL ++ Q+A+ E KEL + L +E K + L E +L E E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAE-- 907
Query: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ-LASLYSALQ 1190
E ++R + AK +L+ L E++LE E+ G Q QA+ + +A L+
Sbjct: 908 ---EMRVRLA-----AKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 956
Query: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
+ L +R +L L ++AEA + KL
Sbjct: 957 EQLEEEEAARQKLQ----------------------------LEKVTAEA---KIKKLED 985
Query: 1251 DLWKTQQTRDVLRDQVQKLEERLTDT------EAEKSQVHTELQ--------DLQRQLSQ 1296
++ + L + + LEER++D E EK++ T+L+ +L+ +L +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
++ + + E + LE + + HE +A LQ+++ AEL+ A+ E EL QAA L +
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQI--AELKMQLAKKEEEL-QAALARLDDE 1102
Query: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
+ A+ + R L+EDL + R+A ++ E +AL+ + E
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-DTLDS 1161
Query: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
A Q+ L A+RE+EV L+ + E + E Q + +K Q V+
Sbjct: 1162 TATQQELR------AKREQEVTVLKKALDEETRSHEAQVQEMR------QKHAQAVEELT 1209
Query: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK-- 1534
EQ+++ ++ ++ L+ +++ L + + + +++ E ++ LE Q+ EL+ K
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 1535 ---------DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRET 1585
+ + + +V+ + L E A++L ++ + Q + +EL +
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 1586 QRVALTHLTLDLEERSQELQAQSSQI----HDLESHSTVLARELQERDQEVKSQREQIEE 1641
Q++ ++ LEE LQ Q + +LE H + L +L + ++++ +E
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
L+ K+ +++E Q+ + LE + R L+++L+ + + L + R+L +
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----LQQELDDLVVDL-DNQRQLVS 1444
Query: 1702 -----QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE 1756
QR+ Q AEE K S + + R+KE + + E E K++LE
Sbjct: 1445 NLEKKQRKFDQLLAEE-KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503
Query: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
+ T+ +L +++V + + + + E +++L++Q++E + L + +
Sbjct: 1504 R-----------TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 1817 QELEALQQEQQQAQGQEERVKEKADA-LQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875
EL+A + + + + + +K + + LQ EQ ++ +L +++ + LE+E
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE---LEDER 1609
Query: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
A +++ GDL+ L LQ A + +E ++ Q LQAQ +
Sbjct: 1610 KQRALAAAAKKKLEGDLKD---------LELQADSAIKGREEAIK----QLRKLQAQ--M 1654
Query: 1936 KERDQELEALRAESQ----SSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
K+ +ELE RA +++ E+ A++ L + AA + ++Q LE+ EL+
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 1992 RSLEASTA---TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ------ 2042
L +S + LQ +A QLEE L ++G ++ R ++ QQ +Q
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 2043 ---ALAQRDEELRHQQERE------QLLE---------KSLAQRVQENMIQEKQNLGQER 2084
+ AQ++E R Q ER+ +L E KS ++ + Q ++ + QE
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 2085 EEEEI--RGLHQSVRELQLTLAQKEQE---ILELRETQQRNNLEALPHSHKTSPMEEQSL 2139
E++ + L Q ++L+ L Q E E + +E ++ N + EE+S
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 2140 KLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171
++++ +LQREL+ TE+ E RE
Sbjct: 1895 RINANRRKLQRELD------EATESNEAMGRE 1920
Score = 195 bits (496), Expect = 4e-49
Identities = 270/1154 (23%), Positives = 494/1154 (42%), Gaps = 158/1154 (13%)
Query: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
L KT+E +++A +EL Q SQ EK LQ+++ + L ++++ + L
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
E + +E +E E + Q E+ + Q + D+ + + EE A+ +
Sbjct: 921 EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE--EAARQKLQLEKV 974
Query: 370 ELDSSIFSQFD----YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE-AVNL--LQQQ 422
++ I D D + L+ R +L R + DL LA +E A NL L+ +
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEER---ISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 423 HDQW-----------EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD----SLSKEREL 467
H+ E+ + L + +KL G+ Q DLQ ++ L+K+ E
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGD---------SAQGQKEEQQEELHLA 517
LQ A L ++ ++R + + LQ D A+ QK + EEL
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 518 VRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ--------TEVTAA 569
E E + + +++ E+ L++AL+ E QE E+T
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629
L + +++ A L ++ TL+ E ADL A +L L +A K + + +LE + Q +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQA----KQEVEHKKKKLEAQVQEL 1264
Query: 630 CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK 689
S+ E+AR AE + L + + L +AE +L D+ + +
Sbjct: 1265 QSKCSDGERAR-------AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
++ Q+ L E Q+ +T+L QL +E ++ L ++ K+ L R + L ++L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
+ QD A ++ L K+ + + QQ +LE + K +Q E+
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-------KTKNRLQQELD 1430
Query: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
L ++LD +R Q + R+ Q E K + ++ + REK K S
Sbjct: 1431 DLVVDLDNQR-QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS-- 1487
Query: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE------ERTQAESALCQMQLET 923
LA+ALE K ELE K + EME + + +++ E +++ AL + Q+E
Sbjct: 1488 ---LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-ETQMEE 1543
Query: 924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGI--LQTQLQEAQRELK 981
K ++ LE LQ ++ +LR ++ +Q LK Q + Q +E +R+L+
Sbjct: 1544 MKTQLEELEDELQATED--------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
++ +L +++ + K L+ ++DL+ Q DS +E ++LR+ Q
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----LQADSAIKGREEAIKQLRKLQ 1651
Query: 1042 -EYNRIQKELEREKAS---LTLSLMEKEQRLLVLQEADSIR-QQELSALRQDMQEAQGEQ 1096
+ Q+ELE +AS + + E E++ L EAD ++ Q++L+A + ++A E+
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEK 1710
Query: 1097 KELSAQMELL---RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
+EL+ ++ R +++++ A+ AQL EELE E+Q + + A Q
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELE-----EEQGNMEAMSDRVRKATQQ 1765
Query: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
S E E A++ + Q + Q L S L + G+V
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV----------------- 1808
Query: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
+S FK + AL A+ +A ++ Q+ + Q L+ + +KL+E L
Sbjct: 1809 ----------KSKFK--STIAALEAK-IAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855
Query: 1274 TDTEAEKSQV----------HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET-- 1321
E E+ + ++ L+RQL + +EE + + L+ EL E E+
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 1322 -----MASLQSRLR 1330
+ +L+S+LR
Sbjct: 1916 AMGREVNALKSKLR 1929
Score = 183 bits (464), Expect = 2e-45
Identities = 267/1151 (23%), Positives = 509/1151 (44%), Gaps = 155/1151 (13%)
Query: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
++ T+++ L + Q +E ++K E EL + E ++ L+ E + +
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAK--------EDELQKTKERQQKAENELKELEQKHSQLTE 887
Query: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
E+ LLQ E LQA E A+A E++R +A K + EE+ E E
Sbjct: 888 EKNLLQ----------EQLQAET-ELYAEA-------EEMRVRLAAKKQELEEILHEMEA 929
Query: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
L+E+ + +G+ LQ + Q + + EE++E E++ QK LE +
Sbjct: 930 R--LEEEED----RGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLEKV 974
Query: 1462 SLD--LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET 1519
+ + +KK E+ + +Q +L K R +LE ER LT + E K+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLE-------ERISDLTTNLAEEEEKAKNLTK 1027
Query: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK-E 1578
+N E + ELE + + E R +++ LK++L E A + E ++ Q +K +
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKL---EGDASDFHEQIADLQAQIAELKMQ 1084
Query: 1579 LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE----RDQEVKS 1634
L + E + AL L ++ +++ L+ +I +LE H + L +L R++ K
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1635 QREQIEELQRQKEHL--TQDLERRDQELMLQKER-IQVLEDQRTRQTKILEEDLEQIKLS 1691
+R+ EEL+ K L T D QEL ++E+ + VL+ +T+ E +++++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 1692 LRERGRELTTQ-RQLMQERA--EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH-E 1747
+ ELT Q Q + +A ++ K + + L +L ++EVE +++ + +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 1748 LQELKD----------QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELK 1797
+QEL+ +L ++ L +V + +L++ E + + L + + Q
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ---- 1316
Query: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Q Q L E R +L L++E+ Q Q + E L+ + ++ L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEH 1917
+LQD LEE + ++ L + + A + EK LQQ+ + +
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD- 1435
Query: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQ--SSRHQEEAARARAEALQEALGKAHA 1975
D+ Q + L+++ ++ + L AE + SS++ +E RA AEA +E KA +
Sbjct: 1436 -------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-REKETKALS 1487
Query: 1976 ALQGKEQHLLEQAELSRS---LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR 2032
+ E+ L + EL R+ L+A L +S D + +LE++ R E ++++ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 2033 YQEDVQQLQQALAQRDEELRHQQEREQL---LEKSLAQRVQENMIQEKQ----------N 2079
+E +LQ A D +LR + + L E+ L R ++N + +Q
Sbjct: 1548 LEELEDELQ---ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 2080 LGQEREEEEI-----RGLHQSVRELQL----TLAQKEQEILELRETQQR-----NNLEAL 2125
L ER++ + + L +++L+L + +E+ I +LR+ Q + LE
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 2126 PHSHKT--SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQT 2183
S + +E K SLE L + E L AA R + ++E E A++LA SL+
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELEL----TRRALEK-ERLHSPGAT--STA 2236
A LQ+ L+A + + + E + Q +E R+A ++ E+L + AT STA
Sbjct: 1725 NA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 2237 ELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR-------- 2288
+ Q ++ +G K ++ + L+ +A+LE +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 2289 ---LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSD 2345
L++ + +L+ L QVE E RK+ + A+ G+ + + ++ + N++
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 2346 AKCVAELQKEV 2356
+ +LQ+E+
Sbjct: 1900 RR---KLQREL 1907
Score = 159 bits (401), Expect = 4e-38
Identities = 210/1033 (20%), Positives = 455/1033 (44%), Gaps = 106/1033 (10%)
Query: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK--KRNQEVDLQQEQIQELEKCRS 1487
+ +EEE++ ++Q+ ++++ QKA EL L+ K + +E +L QEQ+Q + +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQ--QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 1488 VLEHLPMAVQEREQKLTV---QREQIRELEKDR----ETQRNVLEHQLLELEKKDQMIES 1540
E + + + ++Q+L + E E E+DR + +R + Q+L+LE++ +E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ---LEE 961
Query: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
+ Q L+ + VT E +LE+ M+ Q +L +R+ ++ LT +L E
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEE 1018
Query: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
++ + + L++ + EL+ R ++ + R+++E+L+R+ E D + +L
Sbjct: 1019 EEK----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAE--EGKGPSK 1718
Q I L+ Q ++ + L+ L ++ + ++ L R+L ++ E +
Sbjct: 1075 QAQ---IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
A R E K RD +E+E + EL++ D Q + ++ E ++L ++
Sbjct: 1132 AARNKAEKQK---RDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ--------------ELEALQQ 1824
E + Q+QE R++ + L QL++ +RA A D+ EL L Q
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 1825 EQQQAQGQEERVKEKADALQGAL---EQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
+Q+ + ++++++ + LQ E+A L ++ +LQ+ E + E EG+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKA 1303
Query: 1882 VQALEEVLGDLRAESREQEKALLALQQQ---CAEQAQEHEVETRALQDSWLQAQAVLKER 1938
++ ++V L ++ ++ ++ L +Q + + ++ E E +LQD + +
Sbjct: 1304 IKLAKDV-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
++ + L + S+ + + + EAL+E + ++ Q E+A LE +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 1999 ATLQASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE-ELRHQ 2054
LQ LD + RQL L ++ + DQ L ++++ R E E R +
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKF-DQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 2055 QEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR 2114
+ + L ++L + ++ E+ N + E E++ V + + +K + LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQ 1540
Query: 2115 ETQQRNNLEALPHSHKTSPMEEQSLKLD----SLEPRLQREL--------ERLQAALRQT 2162
+ + LE L + E+ L+L+ +L+ + +R+L E+ + RQ
Sbjct: 1541 MEEMKTQLEEL--EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD---SEQQRLQDELELTR 2219
E E ++ + AL+ A K L+++ + +++ R+ + ++LQ +++ +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLG------EVSGVEAEPSPDGMEKQSWRQRLE 2273
R LE R +TA+ + + ++ +++ E +EK+ + L
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK---REAMRAAQAGSLEISKATA 2330
L+ ++ RL+ QL LE+ + + R+A + A+ S E++ +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 2331 SSPTQQDGRGQ-------------------KNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
++ + R Q K+ +A L+ ++ L+ Q+ E ++KQ
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 2372 DYITRSAQTSREL 2384
Q ++L
Sbjct: 1839 AATKSLKQKDKKL 1851
Score = 154 bits (390), Expect = 8e-37
Identities = 227/1119 (20%), Positives = 477/1119 (42%), Gaps = 110/1119 (9%)
Query: 28 QQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQR 87
+QQ AEN+ + K+SQ +++ L +LQA+ Y +E+ RL A Q
Sbjct: 867 RQQKAENELKELEQ-KHSQLTEEKNL-LQEQLQAETELYAE-AEEMRVRLAAK----KQE 919
Query: 88 WENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSR 147
E + L E+ RLEEE+ R + L ++ M D+ + E+ + + +
Sbjct: 920 LEEI----LHEMEARLEEEEDRGQQLQAERKKMAQQM--LDLEEQLEEEEAARQKLQLEK 973
Query: 148 ARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD----RDLM 203
E K+ +E E + + LS R+++ R L A + ++L
Sbjct: 974 VTAEAKIKK----LEDEIL---VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 204 ELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHER 263
+LK +H + L +RL +SR+ L ++LE +A +
Sbjct: 1027 KLKNKHESMISELE---VRLKKEEKSRQE----------------LEKLKRKLEGDASDF 1067
Query: 264 SQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
+++ L++Q K +L + EL A L + + +K +RE LE + ++L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE----LEGHISDL 1123
Query: 324 MEH---EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
E E + A+++K L + ++ + + + D+ A E + ++ +
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
++ V+ + + QAV++L +QL + A L + E+E L L+ L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE----- 495
+ + + L+ +V L + ++AR EL ++ L+ E + + E
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 496 LQLQGD--SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSH 553
++L D S Q ++ QE L R++ + L LE +++ +L EA ++
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613
L + ++ L ++ L + + E+ +L + +A + L K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 614 GLNQQL--LQLEEENQ-SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
L Q+L L ++ +NQ + S +E ++ + L LAE + ++ EA+ ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL---LAEEKNISSKYADERDRAEAEARE 1480
Query: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
E L L + E KEE+ E L+ ++ ++ + + V E
Sbjct: 1481 KETKALSLARALEEALEAKEEL-----------ERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
E + K ALE +++ ++ ++L ++LQ AK LE ++ + KGQ
Sbjct: 1530 LE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM----------QALKGQF 1576
Query: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
E +Q + E + +++ E +TE ++R AA + E + K Q +A
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 851 ---HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA---Q 904
E+ + QLR+ + + + ++ LE + E+ KE + + ++++A Q
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRE-----LEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
+E+ AE A Q LE E E L + L + L D ++LE ++ + +EQ
Sbjct: 1692 LQEDLAAAERARKQADLEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS---LLQDKMDLQKQVEDL------ 1015
+ ++++A ++ ++ + + + + Q+ S+ L + +L+ ++ ++
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 1016 --KSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073
KS + A + +E++V+++ RE Q + K+ +++ + L + ++ + +E
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 1074 ADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE 1112
+ L++ ++EA+ E + ++A L++E+ E
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 84.7 bits (208), Expect = 1e-15
Identities = 162/816 (19%), Positives = 314/816 (38%), Gaps = 158/816 (19%)
Query: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ 60
+++ N + Q L E + L + + + A+ ++L+ +E Q L + L
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE--QEVTVLKKALD 1184
Query: 61 AKVLQYRSWCQELEKRLEATGGPIPQRWENVE--EPNLDELLVRLEEEQQRCESLAEVNT 118
+ + + QE+ ++ + ++ E + + NLD+ LE+E V
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 119 QLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLL 178
Q + +E +A ++++ D RAR EL K + Q E E G L G+ +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 179 SLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRM 238
L ++V + S+ +D EL E R ++ T +L S + M
Sbjct: 1305 KLAKDVASL--------SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 239 DGREPAQL---------------LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQD 283
+ ++ + L A T E +E +R Q+ I+ +Q EKA D
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 284 RVT--------ELSALLTQSQKQNEDYEKMIKALRETVEIL------ETNHTELMEHEAS 329
++ EL L+ Q + + K R+ ++L + + + + +
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 330 LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDY----QDAD 385
+R + + LSL + +++ + E + + E++ + S+ D + +
Sbjct: 1477 EAREKETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELE 1531
Query: 386 KALTLVRSVLTRRRQAVQDLRQQLAGCQEA-----VNL----------LQQQHDQWEEEG 430
K+ + + + + +++L +L ++A VN+ LQ + +Q EE+
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 431 KALRQRLQKLTGE--------------RDTLAGQTVDLQGEVDSLSKERELLQKAREELR 476
+ L+++L + E + L G DL+ + DS K RE K +L+
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651
Query: 477 QQLEVLEQEAWRLRRVNVEL-------------------QLQGDSAQGQ---------KE 508
Q++ ++E R E+ QLQ D A + KE
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 509 EQQEELHLAVRERERLQEMLMGLEAK---------------------------QSESLS- 540
E EEL ++ R LQ+ LEA+ Q+E LS
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 541 ELITLREALESSHLEGELLRQEQTEVTAALARAEQSI-AELSSSENTLKTEVADLRAA-- 597
EL T R + + + L ++ E+ + L E ++ ++ S+ L+ ++A L
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 598 --AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE 655
A + A ++L L + LLQ+E+E + E AE+ ++
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----------- 1880
Query: 656 ALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
L+ QL++AEE + A+ R +Q E +E
Sbjct: 1881 -------QLKRQLEEAEEESQRINANRRKLQRELDE 1909
Score = 78.2 bits (191), Expect = 9e-14
Identities = 120/560 (21%), Positives = 246/560 (43%), Gaps = 60/560 (10%)
Query: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
A+ ++Q A+ +Q+ CA + + L V ++ ++E++A E Q ++
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-EEEMQAKEDELQKTK 865
Query: 1954 HQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
+++ A + L++ H+ L ++ L EQ + L A ++ L A +
Sbjct: 866 ERQQKAENELKELEQK----HSQLTEEKNLLQEQLQAETELYAEAEEMRVRL---AAKKQ 918
Query: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL------LEKSLAQ 2067
+LEE L E +++++ R Q+ +Q ++ +AQ+ +L Q E E+ LEK A+
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQ-LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 2068 RV-------------QENMIQEKQNLGQER---------EEEE-------IRGLHQS-VR 2097
Q N + +++ L +ER EEEE ++ H+S +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
EL++ L ++E+ EL + +++ +A + + ++ Q + L+ +L ++ E LQA
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ---IAELKMQLAKKEEELQA 1094
Query: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELEL 2217
AL + + EI + A + + + +S LQE +A+ + + +++ L +ELE
Sbjct: 1095 ALARLDD-EIAQKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 2218 TRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
+ LE + L S + EL ++ EQ V + + ++ E + Q RQ+ Q
Sbjct: 1151 LKTELE-DTLDS--TATQQELRAKREQEVTVLK-KALDEETRSHEAQVQEMRQKHA---Q 1203
Query: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
AV L + +R L + +E+E L E QA K Q+
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 2338 GRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL-L 2396
+ + + + AEL +V LQ ++ + ++ + ++++A L L + L
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 2397 AVAQAPEATVLEAETRRLDE 2416
+ + + + R+L+E
Sbjct: 1324 LQEETRQKLNVSTKLRQLEE 1343
Score = 63.9 bits (154), Expect = 2e-09
Identities = 125/588 (21%), Positives = 235/588 (39%), Gaps = 98/588 (16%)
Query: 20 LEEQVLALQQQMAENQAASWR----------KLKNSQEAQQRQATLVRKLQAKVLQYRSW 69
LEE+ +LQ Q+ E A +L +S++ Q A+ V L+ +++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 70 CQELEKRLEATGGPIP--QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL------- 120
+ L ++ E ++ +N + LD+L+V L+ ++Q +L + +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 121 -RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLS 179
+ + AD ++A E EK T S AR E++ ++E+ LK E L+S
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT--NKMLKAEMEDLVS 1518
Query: 180 LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLT---CCLRLTVGAQSREPNGSG 236
+V + K A + + E+K + L L LRL V Q+ +
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 237 RMDGREPAQLLLLLAKTQELEKEAHERSQEL------------IQLKSQGDLEKAELQ-- 282
+ R+ K ++L+++ HE EL + K +GDL+ ELQ
Sbjct: 1579 DLQARDEQNE----EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 283 ----------DRVTELSALLTQSQKQNEDY--------------EKMIKALRETVEILET 318
++ +L A + Q++ ED EK K+L + L+
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 319 N--------------HTELMEHEASL--SRNA-QEEKLSLQQVIKDITQVMVEEGDNI-- 359
+ EL E AS RNA Q+EK L+ I + + + EE N+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 360 -----------AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD-LRQ 407
A+ +E + E ++ ++ Q ++ +RS L AV+ +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 408 QLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL 467
+A + + L++Q +Q E +A + L++ + + Q D + + ++ E
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
++L++QLE E+E+ R+ +LQ + D A E E++
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 48.5 bits (114), Expect = 8e-05
Identities = 83/368 (22%), Positives = 147/368 (39%), Gaps = 49/368 (13%)
Query: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPMEEQSLKLDSLE 2145
+++ L Q R+ + + KE E+ + +E QQ+ N L+ L H + EE++L L+
Sbjct: 840 KVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNL----LQ 893
Query: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
+LQ E E A E + K Q+L L + +A + ++ LQA +
Sbjct: 894 EQLQAETELYAEA----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949
Query: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
+ L+++LE A +K +L T+ A++ + E+ ++ + + E+
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEK--VTAEAKIKKLED------EILVMDDQNNKLSKER 1001
Query: 2266 QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE----------RERRKLKRE-- 2313
+ +R+ L +A E L + + S + ++E +E KLKR+
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 2314 ----------AMRAAQAGSLEISKATASSPTQ------QDGRGQKNSDAKCVAELQKEVV 2357
A AQ L++ A Q D QKN+ K + EL+ +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 2358 LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATV-LEAETRRLDE 2416
LQ L ER + + EL L L +L + A E E E L +
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 2417 SLTQSLTS 2424
+L + S
Sbjct: 1182 ALDEETRS 1189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.123 0.312
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,253,291
Number of Sequences: 37866
Number of extensions: 3721537
Number of successful extensions: 125173
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 973
Number of HSP's successfully gapped in prelim test: 1726
Number of HSP's that attempted gapping in prelim test: 21107
Number of HSP's gapped (non-prelim): 31888
length of query: 2442
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2323
effective length of database: 13,741,464
effective search space: 31921420872
effective search space used: 31921420872
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.