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Search of human proteins with 217330644
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217330644 WD repeat domain 12 protein [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 870 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 105 8e-23
gi|16554627 WD repeat domain 5 [Homo sapiens] 105 8e-23
gi|23199987 WD repeat domain 5B [Homo sapiens] 103 3e-22
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 9e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 9e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 9e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 94 2e-19
gi|41281564 WD repeat domain 37 [Homo sapiens] 94 3e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 93 4e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 93 4e-19
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 93 4e-19
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 93 4e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 93 4e-19
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 93 4e-19
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 88 1e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 84 2e-16
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 84 2e-16
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 84 2e-16
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 84 2e-16
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 84 2e-16
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa... 82 9e-16
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa... 82 9e-16
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi... 82 9e-16
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 81 2e-15
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens] 81 2e-15
gi|4757988 WD repeat domain 39 [Homo sapiens] 80 3e-15
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 80 5e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 8e-15
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 79 1e-14
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 870 bits (2249), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ 60
MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ
Sbjct: 1 MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ 60
Query: 61 FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD 120
FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD
Sbjct: 61 FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD 120
Query: 121 KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK 180
KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK
Sbjct: 121 KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK 180
Query: 181 ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT 240
ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT
Sbjct: 181 ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT 240
Query: 241 EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF 300
EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF
Sbjct: 241 EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF 300
Query: 301 NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS 360
NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS
Sbjct: 301 NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS 360
Query: 361 GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH 420
GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH
Sbjct: 361 GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH 420
Query: 421 VGA 423
VGA
Sbjct: 421 VGA 423
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 105 bits (262), Expect = 8e-23
Identities = 88/312 (28%), Positives = 145/312 (46%), Gaps = 41/312 (13%)
Query: 100 HDDWISSIKGAE--EWILTGSYDKTSRIW-SLEGKSIMTIVGHTDVVKDVAWVKKDSLSC 156
H +SS+K + EW+ + S DK +IW + +GK TI GH + DVAW S S
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW---SSDSN 100
Query: 157 LLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
LL+SAS D+T+ +W+ + K L +GH+ V + SGS+D+ ++IW
Sbjct: 101 LLVSASDDKTLKIWDVS----SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 217 STVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSAS 275
T + TL H + VS+V ++ D I S+S
Sbjct: 157 DVK--------------------------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190
Query: 276 WDHTIRVWDVESGSLKSTLTG--NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
+D R+WD SG TL N + + +SP K + + + D ++LWD +K L
Sbjct: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCL 249
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVD 393
+ + + + +S T + ++SGS DN+V +W+ ++ K + L H D V+S
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGHTDVVISTA 308
Query: 394 WTDTGLLLSGGA 405
T +++ A
Sbjct: 309 CHPTENIIASAA 320
Score = 89.4 bits (220), Expect = 6e-18
Identities = 72/235 (30%), Positives = 109/235 (46%), Gaps = 39/235 (16%)
Query: 187 GHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLT 246
GH +V S+ +G S S DK++KIW E
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK--------------------- 81
Query: 247 RTPIVTLSGHMEAVSSVLW-SDAEEICSASWDHTIRVWDVESGSLKSTLTG--NKVFNCI 303
T+SGH +S V W SD+ + SAS D T+++WDV SG TL G N VF C
Sbjct: 82 -----TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CC 135
Query: 304 SYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSL 363
+++P + SGS D +R+WD +T G + +L +H+ V++V ++ ++S S
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKT--GKCLK-TLPAHSDPVSAVHFN-RDGSLIVSSSY 191
Query: 364 DNIVKLWDTRS--CKAPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKLYSYRYS 415
D + ++WDT S C L D V V ++ G +L+ DN L + YS
Sbjct: 192 DGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 77.8 bits (190), Expect = 2e-14
Identities = 49/152 (32%), Positives = 85/152 (55%), Gaps = 7/152 (4%)
Query: 252 TLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNKV-FNCISYSPLC 309
TL+GH +AVSSV +S + E + S+S D I++W G + T++G+K+ + +++S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 310 KRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKL 369
L S S D+ +++WD G + +L H+ +V ++P ++SGS D V++
Sbjct: 100 NLLVSASDDKTLKIWD--VSSGKCLK-TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRI 155
Query: 370 WDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLL 401
WD ++ K L L AH D V +V + G L+
Sbjct: 156 WDVKTGKC-LKTLPAHSDPVSAVHFNRDGSLI 186
Score = 39.3 bits (90), Expect = 0.007
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 329 KDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDK 388
K + +L HT V+SVK+SP E L S S D ++K+W K ++ H+
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFE-KTISGHKLG 89
Query: 389 VLSVDWTDTGLLLSGGADNK 408
+ V W+ LL +D+K
Sbjct: 90 ISDVAWSSDSNLLVSASDDK 109
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 105 bits (262), Expect = 8e-23
Identities = 88/312 (28%), Positives = 145/312 (46%), Gaps = 41/312 (13%)
Query: 100 HDDWISSIKGAE--EWILTGSYDKTSRIW-SLEGKSIMTIVGHTDVVKDVAWVKKDSLSC 156
H +SS+K + EW+ + S DK +IW + +GK TI GH + DVAW S S
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW---SSDSN 100
Query: 157 LLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
LL+SAS D+T+ +W+ + K L +GH+ V + SGS+D+ ++IW
Sbjct: 101 LLVSASDDKTLKIWDVS----SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 217 STVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSAS 275
T + TL H + VS+V ++ D I S+S
Sbjct: 157 DVK--------------------------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190
Query: 276 WDHTIRVWDVESGSLKSTLTG--NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
+D R+WD SG TL N + + +SP K + + + D ++LWD +K L
Sbjct: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCL 249
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVD 393
+ + + + +S T + ++SGS DN+V +W+ ++ K + L H D V+S
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGHTDVVISTA 308
Query: 394 WTDTGLLLSGGA 405
T +++ A
Sbjct: 309 CHPTENIIASAA 320
Score = 89.4 bits (220), Expect = 6e-18
Identities = 72/235 (30%), Positives = 109/235 (46%), Gaps = 39/235 (16%)
Query: 187 GHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLT 246
GH +V S+ +G S S DK++KIW E
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK--------------------- 81
Query: 247 RTPIVTLSGHMEAVSSVLW-SDAEEICSASWDHTIRVWDVESGSLKSTLTG--NKVFNCI 303
T+SGH +S V W SD+ + SAS D T+++WDV SG TL G N VF C
Sbjct: 82 -----TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CC 135
Query: 304 SYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSL 363
+++P + SGS D +R+WD +T G + +L +H+ V++V ++ ++S S
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKT--GKCLK-TLPAHSDPVSAVHFN-RDGSLIVSSSY 191
Query: 364 DNIVKLWDTRS--CKAPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKLYSYRYS 415
D + ++WDT S C L D V V ++ G +L+ DN L + YS
Sbjct: 192 DGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 77.8 bits (190), Expect = 2e-14
Identities = 49/152 (32%), Positives = 85/152 (55%), Gaps = 7/152 (4%)
Query: 252 TLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNKV-FNCISYSPLC 309
TL+GH +AVSSV +S + E + S+S D I++W G + T++G+K+ + +++S
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 310 KRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKL 369
L S S D+ +++WD G + +L H+ +V ++P ++SGS D V++
Sbjct: 100 NLLVSASDDKTLKIWD--VSSGKCLK-TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRI 155
Query: 370 WDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLL 401
WD ++ K L L AH D V +V + G L+
Sbjct: 156 WDVKTGKC-LKTLPAHSDPVSAVHFNRDGSLI 186
Score = 39.3 bits (90), Expect = 0.007
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 329 KDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDK 388
K + +L HT V+SVK+SP E L S S D ++K+W K ++ H+
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFE-KTISGHKLG 89
Query: 389 VLSVDWTDTGLLLSGGADNK 408
+ V W+ LL +D+K
Sbjct: 90 ISDVAWSSDSNLLVSASDDK 109
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 103 bits (257), Expect = 3e-22
Identities = 89/312 (28%), Positives = 144/312 (46%), Gaps = 41/312 (13%)
Query: 100 HDDWISSIKGAE--EWILTGSYDKTSRIW-SLEGKSIMTIVGHTDVVKDVAWVKKDSLSC 156
H + +SS+K + EW+ + S D+ IW + +GK T+ GH + DVAW S S
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW---SSDSS 96
Query: 157 LLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
L+SAS D+T+ LW + K L +GH+ V + SGS+D+ +KIW
Sbjct: 97 RLVSASDDKTLKLW----DVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 217 STVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSAS 275
E T + K TLS H + VS+V ++ I S S
Sbjct: 153 -----------EVKTGKCLK---------------TLSAHSDPVSAVHFNCSGSLIVSGS 186
Query: 276 WDHTIRVWDVESGSLKSTLT--GNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
+D R+WD SG TL N + + +SP K + + + D ++LWD ++ L
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD-YSRGRCL 245
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVD 393
+ + + + +S T + ++SGS DN+V +W+ ++ K + L H D V+S
Sbjct: 246 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQGHTDVVISAA 304
Query: 394 WTDTGLLLSGGA 405
T L++ A
Sbjct: 305 CHPTENLIASAA 316
Score = 85.5 bits (210), Expect = 8e-17
Identities = 79/272 (29%), Positives = 125/272 (45%), Gaps = 45/272 (16%)
Query: 151 KDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCR-GHAGSVDSIAVDGSGTKFCSGSW 209
+D+ + L LS+S +Q+ V N AL C GH +V S+ +G S S
Sbjct: 7 RDAKAQLALSSSANQSK-----EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSA 61
Query: 210 DKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DA 268
D+++ IW E TL GH +S V WS D+
Sbjct: 62 DRLIIIWGAYDGKYEK--------------------------TLYGHNLEISDVAWSSDS 95
Query: 269 EEICSASWDHTIRVWDVESGSLKSTLTG--NKVFNCISYSPLCKRLASGSTDRHIRLWDP 326
+ SAS D T+++WDV SG TL G N VF C +++P + SGS D +++W+
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF-CCNFNPPSNLIISGSFDETVKIWEV 154
Query: 327 RTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS--CKAPLYDLAA 384
+T G + +L++H+ V++V ++ ++SGS D + ++WD S C L D
Sbjct: 155 KT--GKCLK-TLSAHSDPVSAVHFN-CSGSLIVSGSYDGLCRIWDAASGQCLKTLVD--D 208
Query: 385 HEDKVLSVDWTDTG-LLLSGGADNKLYSYRYS 415
V V ++ G +L+ DN L + YS
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/92 (35%), Positives = 53/92 (57%), Gaps = 11/92 (11%)
Query: 86 VEKYTAPQPEQ-CMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKSIM-TIVGHTDVV 143
++ YT + E+ C+F + S+ G + WI++GS D IW+L+ K I+ + GHTDVV
Sbjct: 245 LKTYTGHKNEKYCIFAN---FSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 144 KDVAWVKKDSLSCLLLSASM--DQTILLWEWN 173
A ++ L+ SA++ D+TI LW N
Sbjct: 301 ISAACHPTEN---LIASAALENDKTIKLWMSN 329
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 98.6 bits (244), Expect = 9e-21
Identities = 80/273 (29%), Positives = 131/273 (47%), Gaps = 45/273 (16%)
Query: 103 WISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSA 161
W S ++ + I++GS D+T ++W+ E G+ I T+ GHT V+ + +K ++S
Sbjct: 307 WSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-----VVSG 359
Query: 162 SMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPT 221
S D T+ +W+ +E + LH GH +V + DG + SG++D M+K+W
Sbjct: 360 SRDATLRVWD--IETGQ--CLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVW----- 408
Query: 222 DEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIR 281
D E T T + TL GH V S+ + D + S S D +IR
Sbjct: 409 DPE---------------------TETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIR 446
Query: 282 VWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSH 341
VWDVE+G+ TLTG++ L SG+ D +++WD +T H
Sbjct: 447 VWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505
Query: 342 TGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
VT +++ ++ +I+ S D VKLWD ++
Sbjct: 506 QSAVTCLQF---NKNFVITSSDDGTVKLWDLKT 535
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/256 (28%), Positives = 119/256 (46%), Gaps = 39/256 (15%)
Query: 173 NVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTV------------- 219
N R ++K+ +GH V + + G + SGS D LK+WS V
Sbjct: 246 NWRRGELKSPKVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 304
Query: 220 ---PTDEEDE--MEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSA 274
+ D + ST+R K E T I TL GH V + + + + S
Sbjct: 305 GVWSSQMRDNIIISGSTDRTLKVWNAE----TGECIHTLYGHTSTVRCMHLHE-KRVVSG 359
Query: 275 SWDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
S D T+RVWD+E+G L G+ C+ Y +R+ SG+ D +++WDP T+
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETE---T 414
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD--TRSCKAPLYDLAAHEDKVLS 391
+L HT V S+++ H ++SGSLD +++WD T +C ++ L H+
Sbjct: 415 CLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVWDVETGNC---IHTLTGHQSLTSG 468
Query: 392 VDWTDTGLLLSGGADN 407
++ D +L+SG AD+
Sbjct: 469 MELKD-NILVSGNADS 483
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/93 (25%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 84 EYVEKYTAPQPEQCMF----HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG 138
+++ K P+ E C+ H + + S++ +++GS D + R+W +E G I T+ G
Sbjct: 402 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTG 461
Query: 139 HTDVVKDVAWVKKDSLSCLLLSASMDQTILLWE 171
H + + KD+ +L+S + D T+ +W+
Sbjct: 462 HQSLTSGME--LKDN---ILVSGNADSTVKIWD 489
Score = 28.9 bits (63), Expect = 9.2
Identities = 18/76 (23%), Positives = 39/76 (51%), Gaps = 9/76 (11%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG---HTDVVKDVAWVKKDSLS 155
H S ++ + +++G+ D T +IW ++ G+ + T+ G H V + + K
Sbjct: 462 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN---- 517
Query: 156 CLLLSASMDQTILLWE 171
++++S D T+ LW+
Sbjct: 518 -FVITSSDDGTVKLWD 532
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 98.6 bits (244), Expect = 9e-21
Identities = 80/273 (29%), Positives = 131/273 (47%), Gaps = 45/273 (16%)
Query: 103 WISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSA 161
W S ++ + I++GS D+T ++W+ E G+ I T+ GHT V+ + +K ++S
Sbjct: 425 WSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-----VVSG 477
Query: 162 SMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPT 221
S D T+ +W+ +E + LH GH +V + DG + SG++D M+K+W
Sbjct: 478 SRDATLRVWD--IETGQ--CLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVW----- 526
Query: 222 DEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIR 281
D E T T + TL GH V S+ + D + S S D +IR
Sbjct: 527 DPE---------------------TETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIR 564
Query: 282 VWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSH 341
VWDVE+G+ TLTG++ L SG+ D +++WD +T H
Sbjct: 565 VWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623
Query: 342 TGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
VT +++ ++ +I+ S D VKLWD ++
Sbjct: 624 QSAVTCLQF---NKNFVITSSDDGTVKLWDLKT 653
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/256 (28%), Positives = 119/256 (46%), Gaps = 39/256 (15%)
Query: 173 NVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTV------------- 219
N R ++K+ +GH V + + G + SGS D LK+WS V
Sbjct: 364 NWRRGELKSPKVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422
Query: 220 ---PTDEEDE--MEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSA 274
+ D + ST+R K E T I TL GH V + + + + S
Sbjct: 423 GVWSSQMRDNIIISGSTDRTLKVWNAE----TGECIHTLYGHTSTVRCMHLHE-KRVVSG 477
Query: 275 SWDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
S D T+RVWD+E+G L G+ C+ Y +R+ SG+ D +++WDP T+
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETE---T 532
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD--TRSCKAPLYDLAAHEDKVLS 391
+L HT V S+++ H ++SGSLD +++WD T +C ++ L H+
Sbjct: 533 CLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVWDVETGNC---IHTLTGHQSLTSG 586
Query: 392 VDWTDTGLLLSGGADN 407
++ D +L+SG AD+
Sbjct: 587 MELKD-NILVSGNADS 601
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/93 (25%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 84 EYVEKYTAPQPEQCMF----HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG 138
+++ K P+ E C+ H + + S++ +++GS D + R+W +E G I T+ G
Sbjct: 520 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTG 579
Query: 139 HTDVVKDVAWVKKDSLSCLLLSASMDQTILLWE 171
H + + KD+ +L+S + D T+ +W+
Sbjct: 580 HQSLTSGME--LKDN---ILVSGNADSTVKIWD 607
Score = 28.9 bits (63), Expect = 9.2
Identities = 18/76 (23%), Positives = 39/76 (51%), Gaps = 9/76 (11%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG---HTDVVKDVAWVKKDSLS 155
H S ++ + +++G+ D T +IW ++ G+ + T+ G H V + + K
Sbjct: 580 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN---- 635
Query: 156 CLLLSASMDQTILLWE 171
++++S D T+ LW+
Sbjct: 636 -FVITSSDDGTVKLWD 650
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 98.6 bits (244), Expect = 9e-21
Identities = 80/273 (29%), Positives = 131/273 (47%), Gaps = 45/273 (16%)
Query: 103 WISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSA 161
W S ++ + I++GS D+T ++W+ E G+ I T+ GHT V+ + +K ++S
Sbjct: 345 WSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-----VVSG 397
Query: 162 SMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPT 221
S D T+ +W+ +E + LH GH +V + DG + SG++D M+K+W
Sbjct: 398 SRDATLRVWD--IETGQ--CLHVLMGHVAAVRCVQYDGR--RVVSGAYDFMVKVW----- 446
Query: 222 DEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIR 281
D E T T + TL GH V S+ + D + S S D +IR
Sbjct: 447 DPE---------------------TETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIR 484
Query: 282 VWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSH 341
VWDVE+G+ TLTG++ L SG+ D +++WD +T H
Sbjct: 485 VWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543
Query: 342 TGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
VT +++ ++ +I+ S D VKLWD ++
Sbjct: 544 QSAVTCLQF---NKNFVITSSDDGTVKLWDLKT 573
Score = 84.7 bits (208), Expect = 1e-16
Identities = 74/256 (28%), Positives = 119/256 (46%), Gaps = 39/256 (15%)
Query: 173 NVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTV------------- 219
N R ++K+ +GH V + + G + SGS D LK+WS V
Sbjct: 284 NWRRGELKSPKVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 342
Query: 220 ---PTDEEDE--MEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSA 274
+ D + ST+R K E T I TL GH V + + + + S
Sbjct: 343 GVWSSQMRDNIIISGSTDRTLKVWNAE----TGECIHTLYGHTSTVRCMHLHE-KRVVSG 397
Query: 275 SWDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSL 333
S D T+RVWD+E+G L G+ C+ Y +R+ SG+ D +++WDP T+
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETE---T 452
Query: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD--TRSCKAPLYDLAAHEDKVLS 391
+L HT V S+++ H ++SGSLD +++WD T +C ++ L H+
Sbjct: 453 CLHTLQGHTNRVYSLQFDGIH---VVSGSLDTSIRVWDVETGNC---IHTLTGHQSLTSG 506
Query: 392 VDWTDTGLLLSGGADN 407
++ D +L+SG AD+
Sbjct: 507 MELKD-NILVSGNADS 521
Score = 39.7 bits (91), Expect = 0.005
Identities = 24/93 (25%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 84 EYVEKYTAPQPEQCMF----HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG 138
+++ K P+ E C+ H + + S++ +++GS D + R+W +E G I T+ G
Sbjct: 440 DFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTG 499
Query: 139 HTDVVKDVAWVKKDSLSCLLLSASMDQTILLWE 171
H + + KD+ +L+S + D T+ +W+
Sbjct: 500 HQSLTSGME--LKDN---ILVSGNADSTVKIWD 527
Score = 28.9 bits (63), Expect = 9.2
Identities = 18/76 (23%), Positives = 39/76 (51%), Gaps = 9/76 (11%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVG---HTDVVKDVAWVKKDSLS 155
H S ++ + +++G+ D T +IW ++ G+ + T+ G H V + + K
Sbjct: 500 HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN---- 555
Query: 156 CLLLSASMDQTILLWE 171
++++S D T+ LW+
Sbjct: 556 -FVITSSDDGTVKLWD 570
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 94.4 bits (233), Expect = 2e-19
Identities = 79/342 (23%), Positives = 146/342 (42%), Gaps = 77/342 (22%)
Query: 115 LTGSYDKTSRIW-SLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWN 173
+TGSYD+T ++W + G+ + T+ GH +VV +A+ + + + S D+T LW +
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF--NNPYGDKIATGSFDKTCKLW--S 163
Query: 174 VERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR 233
VE K H RGH + ++ + T +GS D K+W +E
Sbjct: 164 VETGK--CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE---------- 211
Query: 234 PRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDA-EEICSASWDHTIRVWDVESGSLKS 292
+ TL GH + S+ ++ + + I + S+DHT+ VWD ++G +
Sbjct: 212 ----------------VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
Query: 293 TLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRT--------------------KDG 331
L G+ + S++ C + +GS D+ +LWD G
Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG 315
Query: 332 SLVSLS-------------------LTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDT 372
L++ + L H G ++ + ++P L++GS D ++WD
Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP-QGNHLLTGSSDKTARIWDA 374
Query: 373 RSCKAPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKLYSYR 413
++ + L L H D++ S + G ++++G DN +R
Sbjct: 375 QTGQC-LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 85.9 bits (211), Expect = 6e-17
Identities = 76/302 (25%), Positives = 130/302 (43%), Gaps = 82/302 (27%)
Query: 114 ILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEW 172
I TGS+DKT ++WS+E GK T GHT ++ + + S L+ + SMD T LW+
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHT---AEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 173 NVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTN 232
+ ++ RGH+ + S++ + SG + +GS+D + +W + T
Sbjct: 207 Q----NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW-----------DADTG 251
Query: 233 RPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLK 291
R + L GH +SS ++ D I + S D T ++WD +G
Sbjct: 252 RK---------------VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 292 STLTGN-------------------------KVFNC------------------ISYSPL 308
+TLTG+ ++F+ IS++P
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
Query: 309 CKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVK 368
L +GS+D+ R+WD +T G + + L HT + S ++ +I+GS DN +
Sbjct: 357 GNHLLTGSSDKTARIWDAQT--GQCLQV-LEGHTDEIFSCAFN-YKGNIVITGSKDNTCR 412
Query: 369 LW 370
+W
Sbjct: 413 IW 414
Score = 80.1 bits (196), Expect = 3e-15
Identities = 60/226 (26%), Positives = 111/226 (49%), Gaps = 37/226 (16%)
Query: 186 RGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGL 245
+ H + ++A++ SG+ F +GS+D+ K+W T +E
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEE---------------------- 126
Query: 246 TRTPIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESGSLKSTLTGNKV-FNC 302
+ TL GH V ++ +++ ++I + S+D T ++W VE+G T G+ C
Sbjct: 127 ----LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVC 182
Query: 303 ISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGS 362
+S++P +A+GS D +LWD ++G V +L H+ + S+ ++ T ++I+GS
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWD--IQNGEEV-YTLRGHSAEIISLSFN-TSGDRIITGS 238
Query: 363 LDNIVKLWDTRSCKAPLYDLAAH--EDKVLSVDWTDTGLLLSGGAD 406
D+ V +WD + + + L H E S +W D L+L+G D
Sbjct: 239 FDHTVVVWDADTGR-KVNILIGHCAEISSASFNW-DCSLILTGSMD 282
>gi|41281564 WD repeat domain 37 [Homo sapiens]
Length = 494
Score = 93.6 bits (231), Expect = 3e-19
Identities = 79/261 (30%), Positives = 128/261 (49%), Gaps = 29/261 (11%)
Query: 137 VGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIA 196
+GH D + DV+ K + +L +AS D T LLW ++E K + GH GSV+SI
Sbjct: 153 IGHRDGIWDVSVAKTQPV--VLGTASADHTALLW--SIETGKCLVKYA--GHVGSVNSIK 206
Query: 197 VDGSGTKFCSGSWDKMLKIWS---TVPTDE---------EDEME--ESTNRPRKKQKTEQ 242
S + S D+ IW +PT + EDE+E + +
Sbjct: 207 FHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSD 266
Query: 243 LGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGN--KV 299
R P+ +L H V + W ++ +ASWD T ++DVE+ L +LTG+ ++
Sbjct: 267 CPTIRVPLTSLKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQEL 326
Query: 300 FNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSL-TSHTGWVTSVKWSPTHEQQL 358
+C ++ P + + + S D RLWD R D S+ S+++ HT VTS + T +
Sbjct: 327 THCCTH-PTQRLVVTSSRDTTFRLWDFR--DPSIHSVNVFQGHTDTVTSAVF--TVGDNV 381
Query: 359 ISGSLDNIVKLWDTRSCKAPL 379
+SGS D VK+WD ++ ++P+
Sbjct: 382 VSGSDDRTVKVWDLKNMRSPI 402
Score = 57.0 bits (136), Expect = 3e-08
Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 61/310 (19%)
Query: 103 WISSIKGAEEWIL-TGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLS 160
W S+ + +L T S D T+ +WS+E GK ++ GH V + + + L+ L+
Sbjct: 160 WDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLA---LT 216
Query: 161 ASMDQTILLWEWNVE--------------RNKVKA----------------------LHC 184
AS DQT +W + V+ ++V+ L
Sbjct: 217 ASGDQTAHIWRYAVQLPTPQPVADTSISGEDEVECSDKDEPDLDGDVSSDCPTIRVPLTS 276
Query: 185 CRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVP-------TDEEDEMEESTNRPRKK 237
+ H G V + G + + SWD+ ++ T + E+ P ++
Sbjct: 277 LKSHQGVVIASDWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQR 336
Query: 238 -------QKTEQLGLTRTPIV----TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVE 286
T +L R P + GH + V+S +++ + + S S D T++VWD++
Sbjct: 337 LVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLK 396
Query: 287 S-GSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWD-PRTKDGSLVSLSLTSHTGW 344
+ S +T+ + N I+ K +A +R +RL+D + L S H
Sbjct: 397 NMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRM 456
Query: 345 VTSVKWSPTH 354
V WS H
Sbjct: 457 VCCSAWSEDH 466
Score = 46.6 bits (109), Expect = 4e-05
Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 34/213 (15%)
Query: 102 DWISSIKGAEEWILTGSYDKTSRIWSLEGKSIM-TIVGHTDVVKDVAWVKKDSLSCLLLS 160
DW+ K A +T S+D+T+ ++ +E ++ ++ GH +++ L+++
Sbjct: 288 DWLVGGKQA----VTASWDRTANLYDVETSELVHSLTGHD---QELTHCCTHPTQRLVVT 340
Query: 161 ASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW---- 216
+S D T LW++ + +++ +GH +V S AV G SGS D+ +K+W
Sbjct: 341 SSRDTTFRLWDFRDP--SIHSVNVFQGHTDTVTS-AVFTVGDNVVSGSDDRTVKVWDLKN 397
Query: 217 -----STVPTDEEDEMEE-----------STNRPRKKQKTEQLGLTRTPIVTLSGHMEAV 260
+T+ TD NR + + L R P + GH V
Sbjct: 398 MRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRSSRQGHRRMV 457
Query: 261 SSVLWSDAEEIC---SASWDHTIRVWDVESGSL 290
WS+ +C + +D W++ +L
Sbjct: 458 CCSAWSEDHPVCNLFTCGFDRQAIGWNINIPAL 490
Score = 37.0 bits (84), Expect = 0.034
Identities = 34/143 (23%), Positives = 63/143 (44%), Gaps = 10/143 (6%)
Query: 255 GHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKR 311
GH + + V + + + +AS DHT +W +E+G G+ N I + P +
Sbjct: 154 GHRDGIWDVSVAKTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQL 213
Query: 312 LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+ S D+ +W + + ++ TS +G V+ S E L G + + D
Sbjct: 214 ALTASGDQTAHIWRYAVQLPTPQPVADTSISG-EDEVECSDKDEPDL-DGDVSS-----D 266
Query: 372 TRSCKAPLYDLAAHEDKVLSVDW 394
+ + PL L +H+ V++ DW
Sbjct: 267 CPTIRVPLTSLKSHQGVVIASDW 289
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 93.2 bits (230), Expect = 4e-19
Identities = 72/280 (25%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLL 158
H + ++ E I+TGS D T R+W + G+ + T++ H + V + + ++C
Sbjct: 306 HTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTC-- 363
Query: 159 LSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST 218
S D++I +W+ + GH +V+ VD S S D+ +K+W+T
Sbjct: 364 ---SKDRSIAVWDM-ASPTDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNT 417
Query: 219 VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDH 278
+ + TL+GH ++ + + D + S S D+
Sbjct: 418 STCEF--------------------------VRTLNGHKRGIACLQYRD-RLVVSGSSDN 450
Query: 279 TIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLW------DPRTKDG 331
TIR+WD+E G+ L G+ ++ CI + KR+ SG+ D I++W DPR G
Sbjct: 451 TIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLVAALDPRAPAG 508
Query: 332 SLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+L +L H+G V +++ E Q++S S D+ + +WD
Sbjct: 509 TLCLRTLVEHSGRVFRLQFD---EFQIVSSSHDDTILIWD 545
Score = 63.2 bits (152), Expect = 4e-10
Identities = 60/243 (24%), Positives = 107/243 (44%), Gaps = 45/243 (18%)
Query: 172 WNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEEST 231
W R+ ++ +HC + V + D K SG D +KIW +++T
Sbjct: 250 WRCGRHSLQRIHCRSETSKGVYCLQYDDQ--KIVSGLRDNTIKIW-----------DKNT 296
Query: 232 NRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLK 291
++ L+GH +V + + D I + S D T+RVWDV +G +
Sbjct: 297 LECKR---------------ILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGEML 340
Query: 292 STLTGNKVFNCISYSPLCKRLASG-----STDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
+TL + +C + L R +G S DR I +WD + + L H V
Sbjct: 341 NTL----IHHCEAVLHL--RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVN 394
Query: 347 SVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGAD 406
V + ++ ++S S D +K+W+T +C+ + L H+ + + + D L++SG +D
Sbjct: 395 VVDFD---DKYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSD 449
Query: 407 NKL 409
N +
Sbjct: 450 NTI 452
Score = 29.6 bits (65), Expect = 5.4
Identities = 19/83 (22%), Positives = 41/83 (49%), Gaps = 15/83 (18%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLEGK----------SIMTIVGHTDVVKDVAWV 149
H++ + I+ + I++G+YD ++W L + T+V H+ V + +
Sbjct: 469 HEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 528
Query: 150 KKDSLSCLLLSASMDQTILLWEW 172
+ ++S+S D TIL+W++
Sbjct: 529 EFQ-----IVSSSHDDTILIWDF 546
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 93.2 bits (230), Expect = 4e-19
Identities = 72/280 (25%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLL 158
H + ++ E I+TGS D T R+W + G+ + T++ H + V + + ++C
Sbjct: 342 HTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTC-- 399
Query: 159 LSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST 218
S D++I +W+ + GH +V+ VD S S D+ +K+W+T
Sbjct: 400 ---SKDRSIAVWDM-ASPTDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWNT 453
Query: 219 VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDH 278
+ + TL+GH ++ + + D + S S D+
Sbjct: 454 STCEF--------------------------VRTLNGHKRGIACLQYRD-RLVVSGSSDN 486
Query: 279 TIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLW------DPRTKDG 331
TIR+WD+E G+ L G+ ++ CI + KR+ SG+ D I++W DPR G
Sbjct: 487 TIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLVAALDPRAPAG 544
Query: 332 SLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+L +L H+G V +++ E Q++S S D+ + +WD
Sbjct: 545 TLCLRTLVEHSGRVFRLQFD---EFQIVSSSHDDTILIWD 581
Score = 63.2 bits (152), Expect = 4e-10
Identities = 60/243 (24%), Positives = 107/243 (44%), Gaps = 45/243 (18%)
Query: 172 WNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEEST 231
W R+ ++ +HC + V + D K SG D +KIW +++T
Sbjct: 286 WRCGRHSLQRIHCRSETSKGVYCLQYDDQ--KIVSGLRDNTIKIW-----------DKNT 332
Query: 232 NRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLK 291
++ L+GH +V + + D I + S D T+RVWDV +G +
Sbjct: 333 LECKR---------------ILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGEML 376
Query: 292 STLTGNKVFNCISYSPLCKRLASG-----STDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
+TL + +C + L R +G S DR I +WD + + L H V
Sbjct: 377 NTL----IHHCEAVLHL--RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVN 430
Query: 347 SVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGAD 406
V + ++ ++S S D +K+W+T +C+ + L H+ + + + D L++SG +D
Sbjct: 431 VVDFD---DKYIVSASGDRTIKVWNTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSD 485
Query: 407 NKL 409
N +
Sbjct: 486 NTI 488
Score = 29.6 bits (65), Expect = 5.4
Identities = 19/83 (22%), Positives = 41/83 (49%), Gaps = 15/83 (18%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLEGK----------SIMTIVGHTDVVKDVAWV 149
H++ + I+ + I++G+YD ++W L + T+V H+ V + +
Sbjct: 505 HEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFD 564
Query: 150 KKDSLSCLLLSASMDQTILLWEW 172
+ ++S+S D TIL+W++
Sbjct: 565 EFQ-----IVSSSHDDTILIWDF 582
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLL 158
H + ++ E I+TGS D T R+W + G+ + T++ H + V + + L+
Sbjct: 279 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-----LM 333
Query: 159 LSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST 218
++ S D++I +W+ + GH +V+ VD S S D+ +K+WST
Sbjct: 334 VTCSKDRSIAVWDM-ASATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWST 390
Query: 219 VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDH 278
+ + TL+GH ++ + + D + S S D+
Sbjct: 391 STCEF--------------------------VRTLNGHKRGIACLQYRD-RLVVSGSSDN 423
Query: 279 TIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLW------DPRTKDG 331
TIR+WD+E G+ L G+ ++ CI + KR+ SG+ D I++W DPR
Sbjct: 424 TIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLQAALDPRAPAS 481
Query: 332 SLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+L +L H+G V +++ E Q+IS S D+ + +WD
Sbjct: 482 TLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIWD 518
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/311 (24%), Positives = 138/311 (44%), Gaps = 57/311 (18%)
Query: 111 EEWILTGSYDKTSRIW---SLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTI 167
+E I++G D + +IW SLE ++T GHT V + + ++ ++++ S D T+
Sbjct: 250 DEKIISGLRDNSIKIWDKTSLECLKVLT--GHTGSVLCLQYDER-----VIVTGSSDSTV 302
Query: 168 LLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEM 227
+W+ N +H H +V + CS D+ + +W +M
Sbjct: 303 RVWDVNTGEVLNTLIH----HNEAVLHLRFSNGLMVTCSK--DRSIAVW---------DM 347
Query: 228 EESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
+T+ ++ L GH AV+ V + D + I SAS D TI+VW +
Sbjct: 348 ASATDITLRR--------------VLVGHRAAVNVVDFDD-KYIVSASGDRTIKVWSTST 392
Query: 288 GSLKSTLTGNKV-FNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
TL G+K C+ Y + + SGS+D IRLWD + G+ + + L H V
Sbjct: 393 CEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWD--IECGACLRV-LEGHEELVR 447
Query: 347 SVKWSPTHEQQLISGSLDNIVKLWDTRSCKAP--------LYDLAAHEDKVLSVDWTDTG 398
+++ ++++SG+ D +K+WD ++ P L L H +V + + +
Sbjct: 448 CIRFD---NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ 504
Query: 399 LLLSGGADNKL 409
++ S D L
Sbjct: 505 IISSSHDDTIL 515
Score = 47.8 bits (112), Expect = 2e-05
Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 42/181 (23%)
Query: 267 DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
D E+I S D++I++WD S LTG+ C+ Y + + +GS+D +R+WD
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWD 306
Query: 326 PRT----------------------------KDGSLVSLSLTSHT---------GWVTSV 348
T KD S+ + S T G +V
Sbjct: 307 VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 366
Query: 349 KWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNK 408
++ ++S S D +K+W T +C+ + L H+ + + + D L++SG +DN
Sbjct: 367 NVVDFDDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNT 424
Query: 409 L 409
+
Sbjct: 425 I 425
Score = 31.6 bits (70), Expect = 1.4
Identities = 19/83 (22%), Positives = 42/83 (50%), Gaps = 15/83 (18%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLEGK----------SIMTIVGHTDVVKDVAWV 149
H++ + I+ + I++G+YD ++W L+ + T+V H+ V + +
Sbjct: 442 HEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD 501
Query: 150 KKDSLSCLLLSASMDQTILLWEW 172
+ ++S+S D TIL+W++
Sbjct: 502 EFQ-----IISSSHDDTILIWDF 519
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLL 158
H + ++ E I+TGS D T R+W + G+ + T++ H + V + + L+
Sbjct: 245 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-----LM 299
Query: 159 LSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST 218
++ S D++I +W+ + GH +V+ VD S S D+ +K+WST
Sbjct: 300 VTCSKDRSIAVWDM-ASATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWST 356
Query: 219 VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDH 278
+ + TL+GH ++ + + D + S S D+
Sbjct: 357 STCEF--------------------------VRTLNGHKRGIACLQYRD-RLVVSGSSDN 389
Query: 279 TIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLW------DPRTKDG 331
TIR+WD+E G+ L G+ ++ CI + KR+ SG+ D I++W DPR
Sbjct: 390 TIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLQAALDPRAPAS 447
Query: 332 SLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+L +L H+G V +++ E Q+IS S D+ + +WD
Sbjct: 448 TLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIWD 484
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/311 (24%), Positives = 138/311 (44%), Gaps = 57/311 (18%)
Query: 111 EEWILTGSYDKTSRIW---SLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTI 167
+E I++G D + +IW SLE ++T GHT V + + ++ ++++ S D T+
Sbjct: 216 DEKIISGLRDNSIKIWDKTSLECLKVLT--GHTGSVLCLQYDER-----VIVTGSSDSTV 268
Query: 168 LLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEM 227
+W+ N +H H +V + CS D+ + +W +M
Sbjct: 269 RVWDVNTGEVLNTLIH----HNEAVLHLRFSNGLMVTCSK--DRSIAVW---------DM 313
Query: 228 EESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
+T+ ++ L GH AV+ V + D + I SAS D TI+VW +
Sbjct: 314 ASATDITLRR--------------VLVGHRAAVNVVDFDD-KYIVSASGDRTIKVWSTST 358
Query: 288 GSLKSTLTGNKV-FNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
TL G+K C+ Y + + SGS+D IRLWD + G+ + + L H V
Sbjct: 359 CEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWD--IECGACLRV-LEGHEELVR 413
Query: 347 SVKWSPTHEQQLISGSLDNIVKLWDTRSCKAP--------LYDLAAHEDKVLSVDWTDTG 398
+++ ++++SG+ D +K+WD ++ P L L H +V + + +
Sbjct: 414 CIRFD---NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ 470
Query: 399 LLLSGGADNKL 409
++ S D L
Sbjct: 471 IISSSHDDTIL 481
Score = 47.8 bits (112), Expect = 2e-05
Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 42/181 (23%)
Query: 267 DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
D E+I S D++I++WD S LTG+ C+ Y + + +GS+D +R+WD
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWD 272
Query: 326 PRT----------------------------KDGSLVSLSLTSHT---------GWVTSV 348
T KD S+ + S T G +V
Sbjct: 273 VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
Query: 349 KWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNK 408
++ ++S S D +K+W T +C+ + L H+ + + + D L++SG +DN
Sbjct: 333 NVVDFDDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNT 390
Query: 409 L 409
+
Sbjct: 391 I 391
Score = 31.6 bits (70), Expect = 1.4
Identities = 19/83 (22%), Positives = 42/83 (50%), Gaps = 15/83 (18%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLEGK----------SIMTIVGHTDVVKDVAWV 149
H++ + I+ + I++G+YD ++W L+ + T+V H+ V + +
Sbjct: 408 HEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD 467
Query: 150 KKDSLSCLLLSASMDQTILLWEW 172
+ ++S+S D TIL+W++
Sbjct: 468 EFQ-----IISSSHDDTILIWDF 485
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 93.2 bits (230), Expect = 4e-19
Identities = 89/325 (27%), Positives = 147/325 (45%), Gaps = 49/325 (15%)
Query: 100 HDDWISSIKGAE-------EWILTGSYDKTSRIW-SLEGKSIMTIVGHTDVVKDVAWVKK 151
H WI+ + ++ + S D + RIW + G+ + GHT V + W
Sbjct: 198 HSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGD 257
Query: 152 DSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDK 211
LL SAS D+TI +W + +GH V+++A+ S D
Sbjct: 258 G----LLYSASQDRTIKVWR----AHDGVLCRTLQGHGHWVNTMAL----------STDY 299
Query: 212 MLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEI 271
L+ + P + ++ Q+ ++ L+R +V G E +
Sbjct: 300 ALRTGAFEPAEASVNPQDLQG---SLQELKERALSRYNLVRGQG------------PERL 344
Query: 272 CSASWDHTIRVWD-VESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPRTK 329
S S D T+ +W E + +TG++ + N + +SP + +AS S D+ I+LWD RT
Sbjct: 345 VSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT- 403
Query: 330 DGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKV 389
G ++ SL H V + WS + L+SGS D+ +K+WD ++ K + DL H D+V
Sbjct: 404 -GKYLA-SLRGHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDVKAQKLAM-DLPGHADEV 459
Query: 390 LSVDWTDTG-LLLSGGADNKLYSYR 413
+VDW+ G + SGG D L +R
Sbjct: 460 YAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 91.7 bits (226), Expect = 1e-18
Identities = 58/168 (34%), Positives = 86/168 (51%), Gaps = 9/168 (5%)
Query: 252 TLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVFNC-ISYSPLC 309
+L GH EAV SV +S + + S S D T+R WD+ + + T G++ + IS+SP
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 310 KRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHE----QQLISGSLDN 365
++LASG + I LWDP T G V +L H+ W+T + W P H + + S S D
Sbjct: 169 RKLASGCKNGQILLWDPST--GKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 366 IVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYR 413
V++WDT + + L H V + W GLL S D + +R
Sbjct: 227 SVRIWDTTAGRCERI-LTGHTQSVTCLRWGGDGLLYSASQDRTIKVWR 273
Score = 68.9 bits (167), Expect = 8e-12
Identities = 60/205 (29%), Positives = 89/205 (43%), Gaps = 43/205 (20%)
Query: 178 KVKALHCC----RGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR 233
+V+A+ C GH+ +V S+A +G SGS D ++ W
Sbjct: 99 RVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL--------------- 143
Query: 234 PRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESG-SLK 291
T TP T GH V S+ WS D ++ S + I +WD +G +
Sbjct: 144 -----------STETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVG 192
Query: 292 STLTG-NKVFNCISYSPL-----CKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWV 345
TL G +K +S+ PL C+ +AS S D +R+WD T G + LT HT V
Sbjct: 193 RTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD--TTAGRCERI-LTGHTQSV 249
Query: 346 TSVKWSPTHEQQLISGSLDNIVKLW 370
T ++W + L S S D +K+W
Sbjct: 250 TCLRWG--GDGLLYSASQDRTIKVW 272
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 93.2 bits (230), Expect = 4e-19
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLL 158
H + ++ E I+TGS D T R+W + G+ + T++ H + V + + L+
Sbjct: 266 HTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG-----LM 320
Query: 159 LSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST 218
++ S D++I +W+ + GH +V+ VD S S D+ +K+WST
Sbjct: 321 VTCSKDRSIAVWDM-ASATDITLRRVLVGHRAAVN--VVDFDDKYIVSASGDRTIKVWST 377
Query: 219 VPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDH 278
+ + TL+GH ++ + + D + S S D+
Sbjct: 378 STCEF--------------------------VRTLNGHKRGIACLQYRD-RLVVSGSSDN 410
Query: 279 TIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLW------DPRTKDG 331
TIR+WD+E G+ L G+ ++ CI + KR+ SG+ D I++W DPR
Sbjct: 411 TIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLQAALDPRAPAS 468
Query: 332 SLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWD 371
+L +L H+G V +++ E Q+IS S D+ + +WD
Sbjct: 469 TLCLRTLVEHSGRVFRLQFD---EFQIISSSHDDTILIWD 505
Score = 71.6 bits (174), Expect = 1e-12
Identities = 77/311 (24%), Positives = 138/311 (44%), Gaps = 57/311 (18%)
Query: 111 EEWILTGSYDKTSRIW---SLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTI 167
+E I++G D + +IW SLE ++T GHT V + + ++ ++++ S D T+
Sbjct: 237 DEKIISGLRDNSIKIWDKTSLECLKVLT--GHTGSVLCLQYDER-----VIVTGSSDSTV 289
Query: 168 LLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEM 227
+W+ N +H H +V + CS D+ + +W +M
Sbjct: 290 RVWDVNTGEVLNTLIH----HNEAVLHLRFSNGLMVTCSK--DRSIAVW---------DM 334
Query: 228 EESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
+T+ ++ L GH AV+ V + D + I SAS D TI+VW +
Sbjct: 335 ASATDITLRR--------------VLVGHRAAVNVVDFDD-KYIVSASGDRTIKVWSTST 379
Query: 288 GSLKSTLTGNKV-FNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
TL G+K C+ Y + + SGS+D IRLWD + G+ + + L H V
Sbjct: 380 CEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWD--IECGACLRV-LEGHEELVR 434
Query: 347 SVKWSPTHEQQLISGSLDNIVKLWDTRSCKAP--------LYDLAAHEDKVLSVDWTDTG 398
+++ ++++SG+ D +K+WD ++ P L L H +V + + +
Sbjct: 435 CIRFD---NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ 491
Query: 399 LLLSGGADNKL 409
++ S D L
Sbjct: 492 IISSSHDDTIL 502
Score = 47.8 bits (112), Expect = 2e-05
Identities = 43/181 (23%), Positives = 76/181 (41%), Gaps = 42/181 (23%)
Query: 267 DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
D E+I S D++I++WD S LTG+ C+ Y + + +GS+D +R+WD
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWD 293
Query: 326 PRT----------------------------KDGSLVSLSLTSHT---------GWVTSV 348
T KD S+ + S T G +V
Sbjct: 294 VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353
Query: 349 KWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNK 408
++ ++S S D +K+W T +C+ + L H+ + + + D L++SG +DN
Sbjct: 354 NVVDFDDKYIVSASGDRTIKVWSTSTCEF-VRTLNGHKRGIACLQYRDR-LVVSGSSDNT 411
Query: 409 L 409
+
Sbjct: 412 I 412
Score = 31.6 bits (70), Expect = 1.4
Identities = 19/83 (22%), Positives = 42/83 (50%), Gaps = 15/83 (18%)
Query: 100 HDDWISSIKGAEEWILTGSYDKTSRIWSLEGK----------SIMTIVGHTDVVKDVAWV 149
H++ + I+ + I++G+YD ++W L+ + T+V H+ V + +
Sbjct: 429 HEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD 488
Query: 150 KKDSLSCLLLSASMDQTILLWEW 172
+ ++S+S D TIL+W++
Sbjct: 489 EFQ-----IISSSHDDTILIWDF 506
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/280 (27%), Positives = 129/280 (46%), Gaps = 44/280 (15%)
Query: 100 HDDWIS--SIKGAEEWILTGSYDKTSRIWSL-EGKSIMTIVGHTDVVKDVAWVKKDSLSC 156
H W+ +++ +W +TGS D+T +IW L GK +++ GH V+ V + S
Sbjct: 203 HLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI---VSTRSP 259
Query: 157 LLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
L S D+ + W+ +E NKV + GH +V + + + + S D +IW
Sbjct: 260 YLFSCGEDKQVKCWD--LEYNKV--IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
Query: 217 STVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAE-EICSAS 275
T+ + TLSGH AV++V AE +I + S
Sbjct: 316 DV--------------------------RTKASVHTLSGHTNAVATVRCQAAEPQIITGS 349
Query: 276 WDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV 334
D TIR+WD+ +G + TLT + K + P ASGS D +I+ W + DGS +
Sbjct: 350 HDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQW--KFPDGSFI 406
Query: 335 SLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
+L+ H + ++ + + L+SG+ + + LWD R+
Sbjct: 407 Q-NLSGHNAIINTL--TVNSDGVLVSGADNGTMHLWDWRT 443
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 33/230 (14%)
Query: 187 GHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLT 246
GH G V IAV+ F +GS D+ +KIW +
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLK---------------------- 239
Query: 247 RTPIVTLSGHMEAVSSVLWSD-AEEICSASWDHTIRVWDVESGSLKSTLTGN-KVFNCIS 304
++L+GH+ V V+ S + + S D ++ WD+E + G+ +
Sbjct: 240 ----LSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLD 295
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
P L + S D R+WD RTK S+ +LS HT V +V+ E Q+I+GS D
Sbjct: 296 LHPTIDVLVTCSRDSTARIWDVRTK-ASVHTLS--GHTNAVATVRCQAA-EPQIITGSHD 351
Query: 365 NIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRY 414
++LWD + K + L H+ V +V + G+ + + +++
Sbjct: 352 TTIRLWDLVAGKTRV-TLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKF 400
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/142 (28%), Positives = 69/142 (48%), Gaps = 7/142 (4%)
Query: 253 LSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCK 310
+SGH+ V + + + S D TI++WD+ SG LK +LTG+ + S
Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259
Query: 311 RLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW 370
L S D+ ++ WD + + V H V + PT + L++ S D+ ++W
Sbjct: 260 YLFSCGEDKQVKCWD---LEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTARIW 315
Query: 371 DTRSCKAPLYDLAAHEDKVLSV 392
D R+ KA ++ L+ H + V +V
Sbjct: 316 DVRT-KASVHTLSGHTNAVATV 336
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 84.3 bits (207), Expect = 2e-16
Identities = 80/300 (26%), Positives = 130/300 (43%), Gaps = 52/300 (17%)
Query: 114 ILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEW 172
+++ S D T ++W E G T+ GHTD V+D+++ D LL S S D TI LW++
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF---DHSGKLLASCSADMTIKLWDF 179
Query: 173 NVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWST-----VPTDEEDEM 227
+ + GH +V S+A+ +G S S DK +K+W V T
Sbjct: 180 Q----GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 228 EESTNRPRK---------KQKTEQLGLTRTPI--VTLSGHMEAVSSVLWSDAEE------ 270
RP + +T ++ + T L H V + W+
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 271 ---------------ICSASWDHTIRVWDVESGSLKSTLTG--NKVFNCISYSPLCKRLA 313
+ S S D TI++WDV +G TL G N V + +S K +
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSG-GKFIL 354
Query: 314 SGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTR 373
S + D+ +R+WD + K +L +H +VTS+ + T +++GS+D VK+W+ R
Sbjct: 355 SCADDKTLRVWDYKNKR---CMKTLNAHEHFVTSLDFHKT-APYVVTGSVDQTVKVWECR 410
Score = 78.2 bits (191), Expect = 1e-14
Identities = 72/273 (26%), Positives = 113/273 (41%), Gaps = 55/273 (20%)
Query: 157 LLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
+++SAS D TI +W++ + +GH SV I+ D SG S S D +K+W
Sbjct: 122 VMVSASEDATIKVWDYETGDFE----RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177
Query: 217 STVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSV-LWSDAEEICSAS 275
+ I T+ GH VSSV + + + I SAS
Sbjct: 178 DFQGFE--------------------------CIRTMHGHDHNVSSVAIMPNGDHIVSAS 211
Query: 276 WDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV 334
D TI++W+V++G T TG++ + + + +AS S D+ +R+W TK+
Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE---C 268
Query: 335 SLSLTSHTGWVTSVKWSPTHEQQ-------------------LISGSLDNIVKLWDTRSC 375
L H V + W+P L+SGS D +K+WD S
Sbjct: 269 KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV-ST 327
Query: 376 KAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNK 408
L L H++ V V + G + AD+K
Sbjct: 328 GMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Score = 60.5 bits (145), Expect = 3e-09
Identities = 56/175 (32%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 214 KIWSTVPTDEEDEME-ESTNRPRKKQKTE--QLGLTRTPI---------VTLSGHMEAVS 261
K W++V ++ ME ES K++ T LG R P LSGH V+
Sbjct: 53 KKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVT 112
Query: 262 SVLWSDAEEIC-SASWDHTIRVWDVESGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDR 319
V++ + SAS D TI+VWD E+G + TL G+ IS+ K LAS S D
Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADM 172
Query: 320 HIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS 374
I+LWD G ++ H V+SV P + ++S S D +K+W+ ++
Sbjct: 173 TIKLWD---FQGFECIRTMHGHDHNVSSVAIMPNGD-HIVSASRDKTIKMWEVQT 223
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 84.3 bits (207), Expect = 2e-16
Identities = 83/309 (26%), Positives = 131/309 (42%), Gaps = 84/309 (27%)
Query: 114 ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWN 173
+ TGSYD +RIW+ +G T+ H + + W +K + +LSA +D+T ++W+ +
Sbjct: 252 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGN---YILSAGVDKTTIIWDAH 308
Query: 174 VERNKVK--------------------------ALHCCR-----------GHAGSVDSIA 196
K + +H CR GH V++I
Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368
Query: 197 VDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGH 256
D SG S S D LKIWS KQ+ I L H
Sbjct: 369 WDPSGMLLASCSDDMTLKIWS------------------MKQE--------VCIHDLQAH 402
Query: 257 MEAVSSVLWSDAEE----------ICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCIS 304
+ + ++ WS + SAS+D T+R+WD+E G TLT ++ V++ ++
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS-VA 461
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
+SP K LASGS D+ + +W+ T+ G+LV TG + V W+ ++ S S D
Sbjct: 462 FSPDGKYLASGSFDKCVHIWN--TQSGNLV--HSYRGTGGIFEVCWNARGDKVGASAS-D 516
Query: 365 NIVKLWDTR 373
V + D R
Sbjct: 517 GSVCVLDLR 525
Score = 69.3 bits (168), Expect = 6e-12
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 51/310 (16%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERN----KVKALHCCR--GH--- 188
GH V AW + +S LL S S D T +W N N ++ HC R GH
Sbjct: 179 GHESEVFICAW---NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 189 -AGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR----------PRKK 237
V S+ + +GT +GS+D +IW+ E+ + + + RK
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-----EDGNLASTLGQHKGPIFALKWNRKG 290
Query: 238 QKTEQLGLTRTPIV----------TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
G+ +T I+ H V W + S S D I V +
Sbjct: 291 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGC 350
Query: 288 GSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
T G+ N I + P LAS S D +++W + + + L +H +
Sbjct: 351 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIY 407
Query: 347 SVKWSPT--------HEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTG 398
++KWSPT L S S D+ V+LWD + L H++ V SV ++ G
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDG 466
Query: 399 LLLSGGADNK 408
L+ G+ +K
Sbjct: 467 KYLASGSFDK 476
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/288 (18%), Positives = 100/288 (34%), Gaps = 61/288 (21%)
Query: 176 RNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPR 235
R K+ A + + A + T S K EE+ N +
Sbjct: 100 REKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAK 159
Query: 236 KKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKST- 293
+ ++ + + L GH V W+ ++ S S D T R+W++ S +
Sbjct: 160 PMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 219
Query: 294 --------------LTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLT 339
+ NK + ++ LA+GS D R+W T+DG+L S +L
Sbjct: 220 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLAS-TLG 275
Query: 340 SHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS------------------------- 374
H G + ++KW+ ++S +D +WD +
Sbjct: 276 QHKGPIFALKWN-RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF 334
Query: 375 ---------------CKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADN 407
C P+ H ++V ++ W +G+LL+ +D+
Sbjct: 335 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 382
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 84.3 bits (207), Expect = 2e-16
Identities = 83/309 (26%), Positives = 131/309 (42%), Gaps = 84/309 (27%)
Query: 114 ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWN 173
+ TGSYD +RIW+ +G T+ H + + W +K + +LSA +D+T ++W+ +
Sbjct: 252 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGN---YILSAGVDKTTIIWDAH 308
Query: 174 VERNKVK--------------------------ALHCCR-----------GHAGSVDSIA 196
K + +H CR GH V++I
Sbjct: 309 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368
Query: 197 VDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGH 256
D SG S S D LKIWS KQ+ I L H
Sbjct: 369 WDPSGMLLASCSDDMTLKIWS------------------MKQE--------VCIHDLQAH 402
Query: 257 MEAVSSVLWSDAEE----------ICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCIS 304
+ + ++ WS + SAS+D T+R+WD+E G TLT ++ V++ ++
Sbjct: 403 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS-VA 461
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
+SP K LASGS D+ + +W+ T+ G+LV TG + V W+ ++ S S D
Sbjct: 462 FSPDGKYLASGSFDKCVHIWN--TQSGNLV--HSYRGTGGIFEVCWNARGDKVGASAS-D 516
Query: 365 NIVKLWDTR 373
V + D R
Sbjct: 517 GSVCVLDLR 525
Score = 69.3 bits (168), Expect = 6e-12
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 51/310 (16%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERN----KVKALHCCR--GH--- 188
GH V AW + +S LL S S D T +W N N ++ HC R GH
Sbjct: 179 GHESEVFICAW---NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235
Query: 189 -AGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR----------PRKK 237
V S+ + +GT +GS+D +IW+ E+ + + + RK
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-----EDGNLASTLGQHKGPIFALKWNRKG 290
Query: 238 QKTEQLGLTRTPIV----------TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
G+ +T I+ H V W + S S D I V +
Sbjct: 291 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGC 350
Query: 288 GSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
T G+ N I + P LAS S D +++W + + + L +H +
Sbjct: 351 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIY 407
Query: 347 SVKWSPT--------HEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTG 398
++KWSPT L S S D+ V+LWD + L H++ V SV ++ G
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDG 466
Query: 399 LLLSGGADNK 408
L+ G+ +K
Sbjct: 467 KYLASGSFDK 476
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/288 (18%), Positives = 100/288 (34%), Gaps = 61/288 (21%)
Query: 176 RNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPR 235
R K+ A + + A + T S K EE+ N +
Sbjct: 100 REKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAK 159
Query: 236 KKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKST- 293
+ ++ + + L GH V W+ ++ S S D T R+W++ S +
Sbjct: 160 PMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 219
Query: 294 --------------LTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLT 339
+ NK + ++ LA+GS D R+W T+DG+L S +L
Sbjct: 220 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLAS-TLG 275
Query: 340 SHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS------------------------- 374
H G + ++KW+ ++S +D +WD +
Sbjct: 276 QHKGPIFALKWN-RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF 334
Query: 375 ---------------CKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADN 407
C P+ H ++V ++ W +G+LL+ +D+
Sbjct: 335 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 382
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 84.3 bits (207), Expect = 2e-16
Identities = 83/309 (26%), Positives = 131/309 (42%), Gaps = 84/309 (27%)
Query: 114 ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWN 173
+ TGSYD +RIW+ +G T+ H + + W +K + +LSA +D+T ++W+ +
Sbjct: 303 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGN---YILSAGVDKTTIIWDAH 359
Query: 174 VERNKVK--------------------------ALHCCR-----------GHAGSVDSIA 196
K + +H CR GH V++I
Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419
Query: 197 VDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGH 256
D SG S S D LKIWS KQ+ I L H
Sbjct: 420 WDPSGMLLASCSDDMTLKIWS------------------MKQE--------VCIHDLQAH 453
Query: 257 MEAVSSVLWSDAEE----------ICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCIS 304
+ + ++ WS + SAS+D T+R+WD+E G TLT ++ V++ ++
Sbjct: 454 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS-VA 512
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
+SP K LASGS D+ + +W+ T+ G+LV TG + V W+ ++ S S D
Sbjct: 513 FSPDGKYLASGSFDKCVHIWN--TQSGNLV--HSYRGTGGIFEVCWNARGDKVGASAS-D 567
Query: 365 NIVKLWDTR 373
V + D R
Sbjct: 568 GSVCVLDLR 576
Score = 69.3 bits (168), Expect = 6e-12
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 51/310 (16%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERN----KVKALHCCR--GH--- 188
GH V AW + +S LL S S D T +W N N ++ HC R GH
Sbjct: 230 GHESEVFICAW---NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 189 -AGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR----------PRKK 237
V S+ + +GT +GS+D +IW+ E+ + + + RK
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-----EDGNLASTLGQHKGPIFALKWNRKG 341
Query: 238 QKTEQLGLTRTPIV----------TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
G+ +T I+ H V W + S S D I V +
Sbjct: 342 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGC 401
Query: 288 GSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
T G+ N I + P LAS S D +++W + + + L +H +
Sbjct: 402 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIY 458
Query: 347 SVKWSPT--------HEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTG 398
++KWSPT L S S D+ V+LWD + L H++ V SV ++ G
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDG 517
Query: 399 LLLSGGADNK 408
L+ G+ +K
Sbjct: 518 KYLASGSFDK 527
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/288 (18%), Positives = 100/288 (34%), Gaps = 61/288 (21%)
Query: 176 RNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPR 235
R K+ A + + A + T S K EE+ N +
Sbjct: 151 REKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAK 210
Query: 236 KKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKST- 293
+ ++ + + L GH V W+ ++ S S D T R+W++ S +
Sbjct: 211 PMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 270
Query: 294 --------------LTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLT 339
+ NK + ++ LA+GS D R+W T+DG+L S +L
Sbjct: 271 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLAS-TLG 326
Query: 340 SHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS------------------------- 374
H G + ++KW+ ++S +D +WD +
Sbjct: 327 QHKGPIFALKWN-RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF 385
Query: 375 ---------------CKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADN 407
C P+ H ++V ++ W +G+LL+ +D+
Sbjct: 386 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 433
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 84.3 bits (207), Expect = 2e-16
Identities = 83/309 (26%), Positives = 131/309 (42%), Gaps = 84/309 (27%)
Query: 114 ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWN 173
+ TGSYD +RIW+ +G T+ H + + W +K + +LSA +D+T ++W+ +
Sbjct: 303 LATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGN---YILSAGVDKTTIIWDAH 359
Query: 174 VERNKVK--------------------------ALHCCR-----------GHAGSVDSIA 196
K + +H CR GH V++I
Sbjct: 360 TGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419
Query: 197 VDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGH 256
D SG S S D LKIWS KQ+ I L H
Sbjct: 420 WDPSGMLLASCSDDMTLKIWS------------------MKQE--------VCIHDLQAH 453
Query: 257 MEAVSSVLWSDAEE----------ICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCIS 304
+ + ++ WS + SAS+D T+R+WD+E G TLT ++ V++ ++
Sbjct: 454 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS-VA 512
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
+SP K LASGS D+ + +W+ T+ G+LV TG + V W+ ++ S S D
Sbjct: 513 FSPDGKYLASGSFDKCVHIWN--TQSGNLV--HSYRGTGGIFEVCWNARGDKVGASAS-D 567
Query: 365 NIVKLWDTR 373
V + D R
Sbjct: 568 GSVCVLDLR 576
Score = 69.3 bits (168), Expect = 6e-12
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 51/310 (16%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERN----KVKALHCCR--GH--- 188
GH V AW + +S LL S S D T +W N N ++ HC R GH
Sbjct: 230 GHESEVFICAW---NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
Query: 189 -AGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNR----------PRKK 237
V S+ + +GT +GS+D +IW+ E+ + + + RK
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-----EDGNLASTLGQHKGPIFALKWNRKG 341
Query: 238 QKTEQLGLTRTPIV----------TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVES 287
G+ +T I+ H V W + S S D I V +
Sbjct: 342 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGC 401
Query: 288 GSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVT 346
T G+ N I + P LAS S D +++W + + + L +H +
Sbjct: 402 DRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIY 458
Query: 347 SVKWSPT--------HEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTG 398
++KWSPT L S S D+ V+LWD + L H++ V SV ++ G
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDG 517
Query: 399 LLLSGGADNK 408
L+ G+ +K
Sbjct: 518 KYLASGSFDK 527
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/288 (18%), Positives = 100/288 (34%), Gaps = 61/288 (21%)
Query: 176 RNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPR 235
R K+ A + + A + T S K EE+ N +
Sbjct: 151 REKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAK 210
Query: 236 KKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKST- 293
+ ++ + + L GH V W+ ++ S S D T R+W++ S +
Sbjct: 211 PMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGST 270
Query: 294 --------------LTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLT 339
+ NK + ++ LA+GS D R+W T+DG+L S +L
Sbjct: 271 QLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW---TEDGNLAS-TLG 326
Query: 340 SHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRS------------------------- 374
H G + ++KW+ ++S +D +WD +
Sbjct: 327 QHKGPIFALKWN-RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF 385
Query: 375 ---------------CKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADN 407
C P+ H ++V ++ W +G+LL+ +D+
Sbjct: 386 ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDD 433
>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
sapiens]
Length = 390
Score = 82.0 bits (201), Expect = 9e-16
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 13/174 (7%)
Query: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
P + L GH + + W+ + + SAS DHTI +WD+ + K+ TG+
Sbjct: 134 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 193
Query: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
V +S+ L + L S + D+ + +WD R+ + S S S+ +HT V + ++P E
Sbjct: 194 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 253
Query: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 254 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307
Score = 58.9 bits (141), Expect = 8e-09
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 16/170 (9%)
Query: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLK----STLTGNKVFNCISYSP 307
+GH V V W E S + D + +WD S + S NC+S++P
Sbjct: 189 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 248
Query: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
+ LA+GS D+ + LWD R L S SH + V+WSP +E L S D
Sbjct: 249 YSEFILATGSADKTVALWDLRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSGTDRR 306
Query: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 307 LNVWD-------LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 349
Score = 55.5 bits (132), Expect = 9e-08
Identities = 67/254 (26%), Positives = 107/254 (42%), Gaps = 47/254 (18%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
GH ++W +LS LLSAS D TI LW+ + E V A GH V+
Sbjct: 140 GHQKEGYGLSW--NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197
Query: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
++ + F S + D+ L IW T S N T P ++
Sbjct: 198 VSWHLLHESLFGSVADDQKLMIWDT----------RSNN-------------TSKPSHSV 234
Query: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
H V+ + ++ E + + S D T+ +WD+ + LK + +K +F + +SP
Sbjct: 235 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ-VQWSPH 293
Query: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 294 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 353
Query: 357 QLISGSLDNIVKLW 370
+ S S DNI+++W
Sbjct: 354 VICSVSEDNIMQVW 367
Score = 47.0 bits (110), Expect = 3e-05
Identities = 60/278 (21%), Positives = 103/278 (37%), Gaps = 62/278 (22%)
Query: 64 MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110
MP + + S +V+ +Y + + P P +C + W ++ G
Sbjct: 98 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 157
Query: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAWVKKDSLSCLLLSAS 162
+L+ S D T +W + EGK + GHT VV+DV+W L S +
Sbjct: 158 ---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE--SLFGSVA 212
Query: 163 MDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDG-SGTKFCSGSWDKMLKIWST--- 218
DQ +++W+ N K H H V+ ++ + S +GS DK + +W
Sbjct: 213 DDQKLMIWDTR-SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 271
Query: 219 -------------------VPTDEEDEMEESTNRPRKKQKTEQLGLTRTP---------- 249
P +E T+R ++G ++P
Sbjct: 272 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 331
Query: 250 IVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285
+ GH +S W+ E ICS S D+ ++VW +
Sbjct: 332 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 369
Score = 36.2 bits (82), Expect = 0.058
Identities = 32/137 (23%), Positives = 54/137 (39%), Gaps = 16/137 (11%)
Query: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
E+IL TGS DKT +W L + + H D + V W + +L S+ D+ +
Sbjct: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 308
Query: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217
+W+ + E + L GH + + + CS S D ++++W
Sbjct: 309 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 368
Query: 218 TVPTDEEDEMEESTNRP 234
DE E + P
Sbjct: 369 MAENIYNDEDPEGSVDP 385
>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
sapiens]
Length = 424
Score = 82.0 bits (201), Expect = 9e-16
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 13/174 (7%)
Query: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
P + L GH + + W+ + + SAS DHTI +WD+ + K+ TG+
Sbjct: 168 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 227
Query: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
V +S+ L + L S + D+ + +WD R+ + S S S+ +HT V + ++P E
Sbjct: 228 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 287
Query: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 288 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 341
Score = 58.9 bits (141), Expect = 8e-09
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 16/170 (9%)
Query: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLK----STLTGNKVFNCISYSP 307
+GH V V W E S + D + +WD S + S NC+S++P
Sbjct: 223 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 282
Query: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
+ LA+GS D+ + LWD R L S SH + V+WSP +E L S D
Sbjct: 283 YSEFILATGSADKTVALWDLRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSGTDRR 340
Query: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 341 LNVWD-------LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 383
Score = 55.5 bits (132), Expect = 9e-08
Identities = 67/254 (26%), Positives = 107/254 (42%), Gaps = 47/254 (18%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
GH ++W +LS LLSAS D TI LW+ + E V A GH V+
Sbjct: 174 GHQKEGYGLSW--NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 231
Query: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
++ + F S + D+ L IW T S N T P ++
Sbjct: 232 VSWHLLHESLFGSVADDQKLMIWDT----------RSNN-------------TSKPSHSV 268
Query: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
H V+ + ++ E + + S D T+ +WD+ + LK + +K +F + +SP
Sbjct: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ-VQWSPH 327
Query: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 328 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387
Query: 357 QLISGSLDNIVKLW 370
+ S S DNI+++W
Sbjct: 388 VICSVSEDNIMQVW 401
Score = 47.0 bits (110), Expect = 3e-05
Identities = 60/278 (21%), Positives = 103/278 (37%), Gaps = 62/278 (22%)
Query: 64 MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110
MP + + S +V+ +Y + + P P +C + W ++ G
Sbjct: 132 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 191
Query: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAWVKKDSLSCLLLSAS 162
+L+ S D T +W + EGK + GHT VV+DV+W L S +
Sbjct: 192 ---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE--SLFGSVA 246
Query: 163 MDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDG-SGTKFCSGSWDKMLKIWST--- 218
DQ +++W+ N K H H V+ ++ + S +GS DK + +W
Sbjct: 247 DDQKLMIWDTR-SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 305
Query: 219 -------------------VPTDEEDEMEESTNRPRKKQKTEQLGLTRTP---------- 249
P +E T+R ++G ++P
Sbjct: 306 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 365
Query: 250 IVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285
+ GH +S W+ E ICS S D+ ++VW +
Sbjct: 366 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 403
Score = 36.2 bits (82), Expect = 0.058
Identities = 32/137 (23%), Positives = 54/137 (39%), Gaps = 16/137 (11%)
Query: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
E+IL TGS DKT +W L + + H D + V W + +L S+ D+ +
Sbjct: 285 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 342
Query: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217
+W+ + E + L GH + + + CS S D ++++W
Sbjct: 343 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 402
Query: 218 TVPTDEEDEMEESTNRP 234
DE E + P
Sbjct: 403 MAENIYNDEDPEGSVDP 419
>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
Length = 425
Score = 82.0 bits (201), Expect = 9e-16
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 13/174 (7%)
Query: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
P + L GH + + W+ + + SAS DHTI +WD+ + K+ TG+
Sbjct: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228
Query: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
V +S+ L + L S + D+ + +WD R+ + S S S+ +HT V + ++P E
Sbjct: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288
Query: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342
Score = 58.9 bits (141), Expect = 8e-09
Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 16/170 (9%)
Query: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLK----STLTGNKVFNCISYSP 307
+GH V V W E S + D + +WD S + S NC+S++P
Sbjct: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283
Query: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
+ LA+GS D+ + LWD R L S SH + V+WSP +E L S D
Sbjct: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSGTDRR 341
Query: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 342 LNVWD-------LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384
Score = 55.5 bits (132), Expect = 9e-08
Identities = 67/254 (26%), Positives = 107/254 (42%), Gaps = 47/254 (18%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
GH ++W +LS LLSAS D TI LW+ + E V A GH V+
Sbjct: 175 GHQKEGYGLSW--NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
Query: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
++ + F S + D+ L IW T S N T P ++
Sbjct: 233 VSWHLLHESLFGSVADDQKLMIWDT----------RSNN-------------TSKPSHSV 269
Query: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
H V+ + ++ E + + S D T+ +WD+ + LK + +K +F + +SP
Sbjct: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ-VQWSPH 328
Query: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388
Query: 357 QLISGSLDNIVKLW 370
+ S S DNI+++W
Sbjct: 389 VICSVSEDNIMQVW 402
Score = 47.0 bits (110), Expect = 3e-05
Identities = 60/278 (21%), Positives = 103/278 (37%), Gaps = 62/278 (22%)
Query: 64 MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110
MP + + S +V+ +Y + + P P +C + W ++ G
Sbjct: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192
Query: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAWVKKDSLSCLLLSAS 162
+L+ S D T +W + EGK + GHT VV+DV+W L S +
Sbjct: 193 ---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE--SLFGSVA 247
Query: 163 MDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDG-SGTKFCSGSWDKMLKIWST--- 218
DQ +++W+ N K H H V+ ++ + S +GS DK + +W
Sbjct: 248 DDQKLMIWDTR-SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306
Query: 219 -------------------VPTDEEDEMEESTNRPRKKQKTEQLGLTRTP---------- 249
P +E T+R ++G ++P
Sbjct: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366
Query: 250 IVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285
+ GH +S W+ E ICS S D+ ++VW +
Sbjct: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
Score = 36.2 bits (82), Expect = 0.058
Identities = 32/137 (23%), Positives = 54/137 (39%), Gaps = 16/137 (11%)
Query: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
E+IL TGS DKT +W L + + H D + V W + +L S+ D+ +
Sbjct: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 343
Query: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217
+W+ + E + L GH + + + CS S D ++++W
Sbjct: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403
Query: 218 TVPTDEEDEMEESTNRP 234
DE E + P
Sbjct: 404 MAENIYNDEDPEGSVDP 420
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 80.9 bits (198), Expect = 2e-15
Identities = 83/324 (25%), Positives = 144/324 (44%), Gaps = 51/324 (15%)
Query: 90 TAPQPEQCMFHDDWISSI---KGAEEWILTGSYDKTSRIWSLEGKS-IMTIVGHTDVVKD 145
TA + ++ + H +SS+ K + + TG D +WS+ + IM++ GHT V+
Sbjct: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68
Query: 146 VAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFC 205
V + ++ L+++ S +I +W+ K L GH ++ S+ G
Sbjct: 69 V---RLNTPEELIVAGSQSGSIRVWDLEA----AKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 206 SGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLW 265
SGS D +K+W R+K + GH +AV + +
Sbjct: 122 SGSQDTNIKLWDI----------------RRKGC----------VFRYRGHSQAVRCLRF 155
Query: 266 S-DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRL 323
S D + + SA+ DHT+++WD+ +G + S G+ N + + P LASGS+DR IR
Sbjct: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 324 WDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI-VKLWDTRSC------- 375
WD + V + G V SV ++P L SG D++ V W+ C
Sbjct: 216 WD---LEKFQVVSCIEGEPGPVRSVLFNP-DGCCLYSGCQDSLRVYGWEPERCFDVVLVN 271
Query: 376 KAPLYDLAAHEDKVLSVDWTDTGL 399
+ DLA D+++ V ++ + +
Sbjct: 272 WGKVADLAICNDQLIGVAFSQSNV 295
Score = 75.1 bits (183), Expect = 1e-13
Identities = 65/224 (29%), Positives = 104/224 (46%), Gaps = 34/224 (15%)
Query: 188 HAGSVDSIAVD-GSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLT 246
HA +V S+ + SG +G D + +WS N+P
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSI-------------NKPNC---------- 55
Query: 247 RTPIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVFNC-IS 304
I++L+GH V SV + EE I + S +IRVWD+E+ + TL G+K C +
Sbjct: 56 ---IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112
Query: 305 YSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD 364
+ P + +ASGS D +I+LWD R K H+ V +++SP + L S + D
Sbjct: 113 FHPYGEFVASGSQDTNIKLWDIRRKG---CVFRYRGHSQAVRCLRFSP-DGKWLASAADD 168
Query: 365 NIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNK 408
+ VKLWD + K + + H V V++ LL+ G+ ++
Sbjct: 169 HTVKLWDLTAGKM-MSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
Length = 425
Score = 80.9 bits (198), Expect = 2e-15
Identities = 52/174 (29%), Positives = 89/174 (51%), Gaps = 13/174 (7%)
Query: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298
P + L GH + + W+ + + SAS DHT+ +WD+ +G K+ TG+
Sbjct: 168 PDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSA 227
Query: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357
V +++ L + L S + D+ + +WD R+ S S + +HT V + ++P E
Sbjct: 228 VVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFI 287
Query: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409
L +GS D V LWD R+ K L+ +H+D++ V W+ + +L S G D +L
Sbjct: 288 LATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341
Score = 58.9 bits (141), Expect = 8e-09
Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 47/254 (18%)
Query: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194
GH ++W +LS LLSAS D T+ LW+ N E V A GH+ V+
Sbjct: 174 GHQKEGYGLSW--NSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 231
Query: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253
+A + F S + D+ L IW T + T P +
Sbjct: 232 VAWHLLHESLFGSVADDQKLMIWDT-----------------------RSNTTSKPSHLV 268
Query: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308
H V+ + ++ E + + S D T+ +WD+ + LK T +K +F + +SP
Sbjct: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQ-VHWSPH 327
Query: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356
+ LAS TDR + +WD +DG L + HT ++ W+P
Sbjct: 328 NETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 387
Query: 357 QLISGSLDNIVKLW 370
+ S S DNI+++W
Sbjct: 388 VICSVSEDNIMQIW 401
Score = 56.2 bits (134), Expect = 5e-08
Identities = 44/170 (25%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLKSTL----TGNKVFNCISYSP 307
+GH V V W E S + D + +WD S + NC+S++P
Sbjct: 223 TGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP 282
Query: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366
+ LA+GS D+ + LWD R L + SH + V WSP +E L S D
Sbjct: 283 YSEFILATGSADKTVALWDLRNLKLKLHTFE--SHKDEIFQVHWSPHNETILASSGTDRR 340
Query: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416
+ +WD L + + + D L + GG K+ + ++P
Sbjct: 341 LNVWD-------LSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP 383
Score = 50.1 bits (118), Expect = 4e-06
Identities = 63/290 (21%), Positives = 102/290 (35%), Gaps = 86/290 (29%)
Query: 64 MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110
MP + H+ S +V+ +Y + P P +C + W S++ G
Sbjct: 132 MPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGH 191
Query: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAW-------------- 148
+L+ S D T +W + EGK + GH+ VV+DVAW
Sbjct: 192 ---LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADD 248
Query: 149 ------------VKKDS---------LSCL---------LLSASMDQTILLWEWNVERNK 178
K S ++CL L + S D+T+ LW+ RN
Sbjct: 249 QKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNL 305
Query: 179 VKALHCCRGHAGSVDSIAVDGSG-TKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKK 237
LH H + + T S D+ L +W EE E++ + P +
Sbjct: 306 KLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPEL 365
Query: 238 QKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285
+ GH +S W+ E ICS S D+ +++W +
Sbjct: 366 ------------LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403
Score = 37.4 bits (85), Expect = 0.026
Identities = 34/136 (25%), Positives = 57/136 (41%), Gaps = 19/136 (13%)
Query: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168
E+IL TGS DKT +W L + T H D + V W + +L S+ D+ +
Sbjct: 285 EFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNET--ILASSGTDRRLN 342
Query: 169 LWEWN----------VERNKVKALHCCRGHAGSVDSIAVDGSGT-KFCSGSWDKMLKIW- 216
+W+ + E + L GH + + + + CS S D +++IW
Sbjct: 343 VWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 402
Query: 217 --STVPTDEEDEMEES 230
+ DEE ++ S
Sbjct: 403 MAENIYNDEESDVTTS 418
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 80.1 bits (196), Expect = 3e-15
Identities = 87/329 (26%), Positives = 142/329 (43%), Gaps = 66/329 (20%)
Query: 120 DKTSRIWSLEG-----KSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV 174
D+ RIW EG KS+++ GH V+ VAW L SAS D T +W+ N
Sbjct: 37 DRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAW---SPCGNYLASASFDATTCIWKKN- 91
Query: 175 ERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRP 234
++ + + GH V S+A SG + S DK + +W DEEDE E
Sbjct: 92 -QDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE---VDEEDEYE------ 141
Query: 235 RKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGS--LK 291
+ L+ H + V V+W ++E + SAS+D T++++ E
Sbjct: 142 --------------CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCC 187
Query: 292 STLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD---PRTKDGSLVSLSLTSHTGWVTS 347
+TL G++ +++ P +RLAS S DR +R+W P + G S S W
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACS---GSDPSWKCI 244
Query: 348 VKWSPTHEQQL-------ISGSL-----DNIVKLWD---TRSCKAPLYDLAAHEDKVLSV 392
S H + + ++G+L D+ ++++ + P + L AH + S
Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQ 304
Query: 393 D-----WT--DTGLLLSGGADNKLYSYRY 414
D W + GLL S D ++ ++Y
Sbjct: 305 DVNCVAWNPKEPGLLASCSDDGEVAFWKY 333
Score = 60.1 bits (144), Expect = 4e-09
Identities = 68/254 (26%), Positives = 104/254 (40%), Gaps = 41/254 (16%)
Query: 100 HDDWISSIKGAEEWIL--TGSYDKTSRIWSL----EGKSIMTIVGHTDVVKDVAWVKKDS 153
H++ + S+ A L T S DK+ +W + E + + + HT VK V W
Sbjct: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163
Query: 154 LSCLLLSASMDQTILLWEWNVERNKVKALHCC---RGHAGSVDSIAVDGSGTKFCSGSWD 210
L L SAS D T+ L+ R + CC GH +V S+A D SG + S S D
Sbjct: 164 L---LASASYDDTVKLY-----REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215
Query: 211 KMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSG-HMEAVSSVLWSD-A 268
+ ++IW E + S + P K I TLSG H + + W
Sbjct: 216 RTVRIWRQYLPGNEQGVACSGSDPSWK-----------CICTLSGFHSRTIYDIAWCQLT 264
Query: 269 EEICSASWDHTIRVWDVESGSLKSTLT----------GNKVFNCISYSPL-CKRLASGST 317
+ +A D IRV+ + S T ++ NC++++P LAS S
Sbjct: 265 GALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSD 324
Query: 318 DRHIRLWDPRTKDG 331
D + W + +G
Sbjct: 325 DGEVAFWKYQRPEG 338
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 8/104 (7%)
Query: 303 ISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGS 362
++++P LAS DR IR+W S+ H V V WSP L S S
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC-GNYLASAS 80
Query: 363 LDNIVKLW----DTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLS 402
D +W D C + L HE++V SV W +G LL+
Sbjct: 81 FDATTCIWKKNQDDFEC---VTTLEGHENEVKSVAWAPSGNLLA 121
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 79.7 bits (195), Expect = 5e-15
Identities = 80/291 (27%), Positives = 123/291 (42%), Gaps = 62/291 (21%)
Query: 100 HDDWISS--IKGAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSC 156
H ++S I ++ L+GS+D T R+W L G + VGHT KDV V S +
Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHT---KDVLSVAFSSDNR 118
Query: 157 LLLSASMDQTILLW------EWNVE-RNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSW 209
++S S D+TI LW ++ V+ + + + C R S + I V S W
Sbjct: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV--------SCGW 170
Query: 210 DKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAE 269
DK++K+W N K KT +G T G++ V+ + D
Sbjct: 171 DKLVKVW---------------NLANCKLKTNHIGHT--------GYLNTVT--VSPDGS 205
Query: 270 EICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSP----LCKRLASGSTDRHIRLWD 325
S D +WD+ G TL G + N + +SP LC +T I++WD
Sbjct: 206 LCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC-----AATGPSIKIWD 260
Query: 326 PRTK------DGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW 370
K ++S S + TS+ WS Q L +G DN+V++W
Sbjct: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWS-ADGQTLFAGYTDNLVRVW 310
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/164 (31%), Positives = 85/164 (51%), Gaps = 7/164 (4%)
Query: 249 PIVTLSGHMEAVSSV-LWSDAEEICSASWDHTIRVWDVESGSLKSTLTGN-KVFNCISYS 306
P L GH VS V + SD + S SWD T+R+WD+ +G+ G+ K +++S
Sbjct: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114
Query: 307 PLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLI-SGSLDN 365
+++ SGS D+ I+LW+ T ++ SH+ WV+ V++SP +I S D
Sbjct: 115 SDNRQIVSGSRDKTIKLWN--TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 366 IVKLWDTRSCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNK 408
+VK+W+ +CK + H + +V + D L SGG D +
Sbjct: 173 LVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGSLCASGGKDGQ 215
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/214 (27%), Positives = 92/214 (42%), Gaps = 26/214 (12%)
Query: 135 TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV-ERNKVKALHCCRGHAGSVD 193
T+ GH V +A + ++LSAS D+TI++W+ E N RGH+ V
Sbjct: 10 TLKGHNGWVTQIATTPQ--FPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67
Query: 194 SIAVDGSGTKFCSGSWDKMLKIWS------------------TVPTDEEDEMEESTNRPR 235
+ + G SGSWD L++W +V ++ S +R +
Sbjct: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127
Query: 236 KKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEE---ICSASWDHTIRVWDVESGSLKS 292
+ LG+ + + S H E VS V +S I S WD ++VW++ + LK+
Sbjct: 128 TIKLWNTLGVCKYTVQDES-HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186
Query: 293 TLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWD 325
G+ + N ++ SP ASG D LWD
Sbjct: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Score = 34.3 bits (77), Expect = 0.22
Identities = 23/78 (29%), Positives = 32/78 (41%), Gaps = 5/78 (6%)
Query: 337 SLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW----DTRSCKAPLYDLAAHEDKVLSV 392
+L H GWVT + +P ++S S D + +W D + P L H V V
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
Query: 393 DWTDTG-LLLSGGADNKL 409
+ G LSG D L
Sbjct: 70 VISSDGQFALSGSWDGTL 87
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 79.0 bits (193), Expect = 8e-15
Identities = 74/307 (24%), Positives = 134/307 (43%), Gaps = 45/307 (14%)
Query: 114 ILTGSYDKTSRIWSLEGK--SIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWE 171
+ + +D+ +W++ G + T+ GH+ V ++ + S+ L SAS D+T+ +W+
Sbjct: 81 LASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM---LFSASTDKTVAVWD 137
Query: 172 WNVERNKVKALHCCRGHAGSVDSIAVDGSGTKF-CSGSWDKMLKIWSTVPTDEEDEMEES 230
+ +VK L +GH V+S G + C+GS D +K+W
Sbjct: 138 -SETGERVKRL---KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI------------ 181
Query: 231 TNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSL 290
RKK I T + ++ +++I S D+ I+VWD+ L
Sbjct: 182 ----RKK----------AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL 227
Query: 291 KSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD-----PRTKDGSLVSLSLTSHTGW 344
T+ G+ +S S L S + D +R+WD P+ + + ++ +
Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN 287
Query: 345 VTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDW-TDTGLLLSG 403
+ WSP + + +GS D V +WDT S + LY L H + V + D +++S
Sbjct: 288 LLRCSWSPDGSK-IAAGSADRFVYVWDTTS-RRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 404 GADNKLY 410
+D +LY
Sbjct: 346 SSDKRLY 352
Score = 73.6 bits (179), Expect = 3e-13
Identities = 68/288 (23%), Positives = 119/288 (41%), Gaps = 46/288 (15%)
Query: 133 IMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSV 192
IM + GH +V K L SA D+ ILLW + + L +GH+G+V
Sbjct: 59 IMLLSGHEG---EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL---KGHSGAV 112
Query: 193 DSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVT 252
+ + G+ S S DK + +W + E E R
Sbjct: 113 MELHYNTDGSMLFSASTDKTVAVW-------DSETGERVKR------------------- 146
Query: 253 LSGHMEAVSSVLWS--DAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCK 310
L GH V+S + + +C+ S D T+++WD+ + T ++++
Sbjct: 147 LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSD 206
Query: 311 RLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW 370
++ SG D I++WD R + ++ ++ H VT + S + L+S ++DN V++W
Sbjct: 207 QIISGGIDNDIKVWDLRQ---NKLTYTMRGHADSVTGLSLS-SEGSYLLSNAMDNTVRVW 262
Query: 371 DTRSCK-----APLYDLAAH--EDKVLSVDWT-DTGLLLSGGADNKLY 410
D R ++ H E +L W+ D + +G AD +Y
Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 78.6 bits (192), Expect = 1e-14
Identities = 71/297 (23%), Positives = 126/297 (42%), Gaps = 42/297 (14%)
Query: 114 ILTGSYDKTSRIWSLEGKSIM-TIVGHTDVVKDVAWVKKDSLSC-----LLLSASMDQTI 167
+ T + ++WS+ +++ T+ GH V + + K ++S L S + D ++
Sbjct: 246 LATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305
Query: 168 LLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEM 227
LW + + + + GH V + SG + +D+ ++W +E
Sbjct: 306 KLWSLDSD----EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEE---- 357
Query: 228 EESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLW-SDAEEICSASWDHTIRVWDVE 286
I+ GH V + + D + D RVWD+
Sbjct: 358 ----------------------ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR 395
Query: 287 SGSLKSTLTGN-KVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWV 345
+G L G+ K I++SP +A+GS D ++WD R + ++ +H V
Sbjct: 396 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR---CVYTIPAHQNLV 452
Query: 346 TSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLS 402
T VK+ P H L++G+ DN K+W T +PL LA HE KV+ +D + G L++
Sbjct: 453 TGVKFEPIHGNFLLTGAYDNTAKIW-THPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
Score = 45.1 bits (105), Expect = 1e-04
Identities = 44/190 (23%), Positives = 80/190 (42%), Gaps = 26/190 (13%)
Query: 116 TGSYDKTSRIWSLEGKS-IMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV 174
T YD++ R+W LE + I+ GH+ V D+A+ + SL+ + +D +W+
Sbjct: 340 TTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAG---TGGLDAFGRVWDLRT 396
Query: 175 ERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS--------TVPTDEE-- 224
R + GH + I +G +GS D K+W T+P +
Sbjct: 397 GR----CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 452
Query: 225 -----DEMEESTNRPRKKQKTEQLGLTR--TPIVTLSGHMEAVSSV-LWSDAEEICSASW 276
+ + + T ++ +P+ TL+GH V + + SD + I + S+
Sbjct: 453 TGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY 512
Query: 277 DHTIRVWDVE 286
D T ++W E
Sbjct: 513 DRTFKLWMAE 522
Score = 43.1 bits (100), Expect = 5e-04
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 13/107 (12%)
Query: 114 ILTGSYDKTSRIWSL-EGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWE- 171
I TGS D T ++W L + + + TI H ++V V + + LL+ + D T +W
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKF--EPIHGNFLLTGAYDNTAKIWTH 479
Query: 172 --WNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIW 216
W+ L GH G V + + G + S+D+ K+W
Sbjct: 480 PGWS-------PLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 42.4 bits (98), Expect = 8e-04
Identities = 44/185 (23%), Positives = 75/185 (40%), Gaps = 34/185 (18%)
Query: 267 DAEEICSASWDHTIRVWDVESGSLKSTLTGNK------VF---NCISYSPLCKRLASGST 317
+++ + +A W ++W V +L TL G+ VF + +S P LAS +
Sbjct: 242 NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAA 301
Query: 318 DRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKA 377
D ++LW + D + HT V V W P+ + L + D +LWD + +
Sbjct: 302 DGSVKLW---SLDSDEPVADIEGHTVRVARVMWHPS-GRFLGTTCYDRSWRLWDLEAQEE 357
Query: 378 PL---------YDLAAHEDKVLSVD---------W---TDTGLLLSGGADNKLYSYRYSP 416
L YD+A H+D L+ W T ++ G ++Y +SP
Sbjct: 358 ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417
Query: 417 TTSHV 421
H+
Sbjct: 418 NGYHI 422
Score = 36.2 bits (82), Expect = 0.058
Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 113 WILTGSYDKTSRIWSLEGKS-IMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLW 170
++LTG+YD T++IW+ G S + T+ GH V + + D L+ + S D+T LW
Sbjct: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLD-ISSDGQ--LIATCSYDRTFKLW 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,701,779
Number of Sequences: 37866
Number of extensions: 732963
Number of successful extensions: 4473
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 2050
Number of HSP's gapped (non-prelim): 1352
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.