Search of human proteins with 217035093

Search of human proteins with 217035093

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
         (759 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...  1513   0.0  
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...  1378   0.0  
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   848   0.0  
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   847   0.0  
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    791   0.0  
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    596   e-170
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   313   5e-85
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    303   3e-82
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   178   2e-44
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   175   1e-43
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   166   1e-40
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   163   6e-40
gi|27886653 potassium voltage-gated channel, subfamily H, member...   162   1e-39
gi|13540549 potassium voltage-gated channel, subfamily H, member...   157   5e-38
gi|27886667 potassium voltage-gated channel, subfamily H, member...   154   2e-37
gi|26051273 voltage-gated potassium channel, subfamily H, member...   148   2e-35
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   148   2e-35
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   146   6e-35
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   145   2e-34
gi|22024390 potassium voltage-gated channel, subfamily H, member...   144   3e-34
gi|27886648 potassium voltage-gated channel, subfamily H, member...   142   9e-34
gi|27886651 potassium voltage-gated channel, subfamily H, member...   139   1e-32
gi|27437001 potassium voltage-gated channel, subfamily H, member...   137   4e-32
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   137   5e-32
gi|26051271 voltage-gated potassium channel, subfamily H, member...   130   3e-30
gi|27886646 potassium voltage-gated channel, subfamily H, member...   127   3e-29
gi|27886665 potassium voltage-gated channel, subfamily H, member...   103   8e-22
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]            60   6e-09
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    59   1e-08
gi|148664240 hypothetical protein LOC146556 isoform 1 [Homo sapi...    57   6e-08

>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score = 1513 bits (3917), Expect = 0.0
 Identities = 759/759 (100%), Positives = 759/759 (100%)

Query: 1   MESRSSPRLECSGAISAHCSLHLPDSSDFQLIFVFLVEMGFHHVGQAGLELLISSDLPTS 60
           MESRSSPRLECSGAISAHCSLHLPDSSDFQLIFVFLVEMGFHHVGQAGLELLISSDLPTS
Sbjct: 1   MESRSSPRLECSGAISAHCSLHLPDSSDFQLIFVFLVEMGFHHVGQAGLELLISSDLPTS 60

Query: 61  ASQSAGITDMKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSAST 120
           ASQSAGITDMKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSAST
Sbjct: 61  ASQSAGITDMKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSAST 120

Query: 121 SEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKE 180
           SEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKE
Sbjct: 121 SEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKE 180

Query: 181 KKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFC 240
           KKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFC
Sbjct: 181 KKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFC 240

Query: 241 ITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVK 300
           ITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVK
Sbjct: 241 ITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVK 300

Query: 301 EELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETR 360
           EELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETR
Sbjct: 301 EELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETR 360

Query: 361 TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVY 420
           TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVY
Sbjct: 361 TNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVY 420

Query: 421 SLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 480
           SLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ
Sbjct: 421 SLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 480

Query: 481 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL 540
           ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL
Sbjct: 481 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL 540

Query: 541 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 600
           DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG
Sbjct: 541 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 600

Query: 601 VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA 660
           VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA
Sbjct: 601 VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA 660

Query: 661 KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM 720
           KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM
Sbjct: 661 KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM 720

Query: 721 QQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST 759
           QQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST
Sbjct: 721 QQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST 759


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score = 1378 bits (3567), Expect = 0.0
 Identities = 690/690 (100%), Positives = 690/690 (100%)

Query: 70  MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP 129
           MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP
Sbjct: 1   MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP 60

Query: 130 HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN 189
           HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN
Sbjct: 61  HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN 120

Query: 190 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW 249
           ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW
Sbjct: 121 ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW 180

Query: 250 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY 309
           TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY
Sbjct: 181 TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY 240

Query: 310 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI 369
           KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI
Sbjct: 241 KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI 300

Query: 370 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL 429
           SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL
Sbjct: 301 SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL 360

Query: 430 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 489
           TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY
Sbjct: 361 TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 420

Query: 490 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF 549
           MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF
Sbjct: 421 MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF 480

Query: 550 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD 609
           ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD
Sbjct: 481 ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD 540

Query: 610 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK 669
           GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK
Sbjct: 541 GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK 600

Query: 670 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT 729
           QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT
Sbjct: 601 QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT 660

Query: 730 KVEKFLKPLIDTEFSSIEGPGAESGPIDST 759
           KVEKFLKPLIDTEFSSIEGPGAESGPIDST
Sbjct: 661 KVEKFLKPLIDTEFSSIEGPGAESGPIDST 690


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  848 bits (2191), Expect = 0.0
 Identities = 425/687 (61%), Positives = 528/687 (76%), Gaps = 21/687 (3%)

Query: 79  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 133
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63

Query: 134 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEE-----KKKKKKEKKSKSDDK 188
           SF+ + +       R   L   +  +   +  ++DQ P+      +  + KE  S+  + 
Sbjct: 64  SFTGQGIA------RLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNA 117

Query: 189 NENKNDPEKKKKKKD-----KEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITL 243
             N    E   + +      K        ++++K+ +KK+ +V+DPS N YY WL  I L
Sbjct: 118 QANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIAL 177

Query: 244 PVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEEL 303
           PV YNW ++I RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  
Sbjct: 178 PVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTN 237

Query: 304 KLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNY 363
           +L   YK+  QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNY
Sbjct: 238 RLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNY 297

Query: 364 PNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLY 423
           PN+FRI NLV+YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLY
Sbjct: 298 PNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLY 357

Query: 424 WSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 483
           WSTLTLTTIGETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+I
Sbjct: 358 WSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKI 417

Query: 484 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 543
           D+IKQYM FR V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTL
Sbjct: 418 DSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTL 477

Query: 544 KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQ 603
           KKVRIF DCEAGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQ
Sbjct: 478 KKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQ 537

Query: 604 FVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTM 663
           FVVLSDGSYFGEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  
Sbjct: 538 FVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKA 597

Query: 664 LEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQK 723
           LEEKG+QILMKD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K
Sbjct: 598 LEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMK 657

Query: 724 LKQRLTKVEKFLKPLIDTEFSSIEGPG 750
           +KQRL+++E  +K   D   +  E PG
Sbjct: 658 MKQRLSQLESQVKGGGDKPLADGEVPG 684


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  847 bits (2189), Expect = 0.0
 Identities = 424/677 (62%), Positives = 524/677 (77%), Gaps = 19/677 (2%)

Query: 79  INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSE-----ESENENPHARG 133
           INTQ S  +  ++ V   ++++ R ENG   + S  ++++S  +     E+       +G
Sbjct: 4   INTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQG 63

Query: 134 SFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKN 193
           SF+ + + +     R  +L    A  +V++         ++ +  + K+  S + N   N
Sbjct: 64  SFTGQGIAR---LSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQAN 120

Query: 194 DPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 253
              ++   + + KK K           KK+ +V+DPS N YY WL  I LPV YNW ++I
Sbjct: 121 VGSQEPADRGRRKKTK-----------KKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLI 169

Query: 254 ARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNL 313
            RACFDELQS+YL  WL+LDY +D++Y++D+ VR RTG+LEQGL+V +  +L   YK+  
Sbjct: 170 CRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTT 229

Query: 314 QFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLV 373
           QFKLDVLSL+PTDL Y K+G NYPE+R NRLL+FSR+FEFF RTETRTNYPN+FRI NLV
Sbjct: 230 QFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLV 289

Query: 374 MYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIG 433
           +YI+IIIHWNAC++++ISK IGFG D+WVYP+I+ PE GRL+RKY+YSLYWSTLTLTTIG
Sbjct: 290 LYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIG 349

Query: 434 ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFR 493
           ETPPPV+D EY+FVVVDFL+GVLIFATIVGN+GSMISNMNA+RAEFQA+ID+IKQYM FR
Sbjct: 350 ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFR 409

Query: 494 NVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCE 553
            V+KD+E RVI+WFDYLW NKKTVDEKEVLK LPDKL+AEIAINVHLDTLKKVRIF DCE
Sbjct: 410 KVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCE 469

Query: 554 AGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYF 613
           AGLLVELVLKL+P V+SPGDYICKKGDIG+EMYII EGKLAVVADDGVTQFVVLSDGSYF
Sbjct: 470 AGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYF 529

Query: 614 GEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILM 673
           GEISILNIKGSK+GNRRTANI+SIGYSDLFCLSKDDLMEALTEYP+AK  LEEKG+QILM
Sbjct: 530 GEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILM 589

Query: 674 KDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEK 733
           KD L+D  +A AG+DPKDLEEKV ++  S+D LQTRFAR+LAEY + Q K+KQRL+++E 
Sbjct: 590 KDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLES 649

Query: 734 FLKPLIDTEFSSIEGPG 750
            +K   D   +  E PG
Sbjct: 650 QVKGGGDKPLADGEVPG 666


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  791 bits (2043), Expect = 0.0
 Identities = 386/574 (67%), Positives = 471/574 (82%), Gaps = 1/574 (0%)

Query: 172 EEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSG 231
           E   K  +E++ + D   E    PE +     +   K ++  +DK  ++K E+ V+DP+G
Sbjct: 78  EWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAG 137

Query: 232 NTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTG 291
           + YY WLF I +PV+YNW +++ARACF +LQ  Y   WL+LDYVSD+VY+ D+F+R RTG
Sbjct: 138 DWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTG 197

Query: 292 YLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMF 351
           +LEQGLLVK+  KL + Y   LQFKLDV S+IPTDL+YF +  + PE+R NRLL F+RMF
Sbjct: 198 FLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMF 257

Query: 352 EFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEF 411
           EFF RTETRTNYPNIFRISNLV+YI++IIHWNAC++Y+ISK+IGFG DTWVYP+I DPE+
Sbjct: 258 EFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEY 317

Query: 412 GRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISN 471
           G LAR+Y+Y LYWSTLTLTTIGETPPPV+D EY+FV+ DFLIGVLIFATIVGN+GSMISN
Sbjct: 318 GYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISN 377

Query: 472 MNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLR 531
           MNA RAEFQA+IDA+K YM FR VSK ME +VI+WFDYLWTNKKTVDE+E+LK LP KLR
Sbjct: 378 MNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLR 437

Query: 532 AEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEG 591
           AEIAINVHL TLKKVRIF DCEAGLLVELVLKL+PQV+SPGDYIC+KGDIG+EMYIIKEG
Sbjct: 438 AEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEG 497

Query: 592 KLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 651
           KLAVVADDGVTQ+ +LS GS FGEISILNIKGSK GNRRTANI+S+GYSDLFCLSKDDLM
Sbjct: 498 KLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLM 557

Query: 652 EALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFA 711
           EA+TEYPDAK +LEE+G++ILMK+GLLD N   A S   D++EK+ ++E +++ L TRF 
Sbjct: 558 EAVTEYPDAKKVLEERGREILMKEGLLDENEV-ATSMEVDVQEKLGQLETNMETLYTRFG 616

Query: 712 RILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSS 745
           R+LAEY   QQKLKQR+T +E  +K   + ++ S
Sbjct: 617 RLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLS 650


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  596 bits (1537), Expect = e-170
 Identities = 285/528 (53%), Positives = 398/528 (75%), Gaps = 1/528 (0%)

Query: 206 KKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDY 265
           K K  E S     + +K + V+DPSG+ YY WL  +  PVMYN  +++ RACF +LQ  Y
Sbjct: 6   KVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGY 65

Query: 266 LEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPT 325
           L  WL+LDY SD++YL+DM VR  TG+LEQG+LV ++ ++ ++Y     F LD+ SL+PT
Sbjct: 66  LVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPT 125

Query: 326 DLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNAC 385
           D++Y +LG + P +RLNR LR  R+FE F RTETRT YPN FRI+ L++YI ++IHWN+C
Sbjct: 126 DVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSC 185

Query: 386 VFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYV 445
           +++++S+ +GFG D WVYPD   P F RL R+Y+YS Y+STL LTT+G+TPPP R+ EY+
Sbjct: 186 LYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYL 245

Query: 446 FVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIK 505
           F+V DFL+ V+ FATI+G++ S+I NMN A A F      +K+YM  ++V++ +E+RVI 
Sbjct: 246 FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVID 305

Query: 506 WFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQ 565
           W+ +L  NKK  +E  +L++LP++LRAE+A++VHL TL +V+IF +CEA LL ELVLKLQ
Sbjct: 306 WYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365

Query: 566 PQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSK 625
           PQ YSPG+Y+C+KGDIG+EMYII+EG+LAVVADDG+TQ+ VL  G YFGEISI+NIKG+ 
Sbjct: 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNM 425

Query: 626 AGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANA 685
           +GNRRTANIKS+GYSDLFCLSK+DL E L+EYP A+T++EEKG++IL+K   LD+N   A
Sbjct: 426 SGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAA 485

Query: 686 GSDPKD-LEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVE 732
               ++  E ++  ++  +D LQT+FAR+LAE ES   K+  R+ ++E
Sbjct: 486 EIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLE 533


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  313 bits (801), Expect = 5e-85
 Identities = 181/580 (31%), Positives = 311/580 (53%), Gaps = 31/580 (5%)

Query: 112  SEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFN--VNNSSNKDQ 169
            SEDD++      S  E+P    S         G  +         A+ N  +       +
Sbjct: 517  SEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFK 576

Query: 170  EPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEE--------------KSKD 215
            E  EK K+K      + D+   K  P KK  +   + K  E               K K 
Sbjct: 577  ERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKH 636

Query: 216  KKEEEKKEVVVIDPSGNTYYN-WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY 274
            +  ++ +    IDP  N  Y  WLF + +   +N  ++  R  F     D + +WL++DY
Sbjct: 637  RPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDY 696

Query: 275  VSDIVYLIDMFV-RTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLG 333
            + D++Y +D+ V +TR  ++  G ++ ++  + N Y  + +FK+D+LSL+P D LY K+G
Sbjct: 697  LCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVG 756

Query: 334  WNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA 393
             N P +RL R L++   FEF  R E+  +   ++R+     Y++  +H N+C++Y  S  
Sbjct: 757  VN-PLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAY 815

Query: 394  IGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLI 453
             G G+  WVY  + +         Y+   Y++  TL TIG  P P    E VF ++++  
Sbjct: 816  QGLGSTHWVYDGVGN--------SYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFT 867

Query: 454  GVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTN 513
            GV  F+ ++G +  ++    A +  +++ +D+  +YM+F  + K ++ RV  W++Y W +
Sbjct: 868  GVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHS 927

Query: 514  KKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGD 573
            +  +DE E++  LPDK+R ++AI+V+ + + KV +F  C+  ++ +++ +L+  VY P D
Sbjct: 928  QGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPND 987

Query: 574  YICKKGDIGREMYIIKEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTA 632
            Y+CKKG+IGREMYII+ G++ V+   DG +  V L  GS FGEIS+L + G   GNRRTA
Sbjct: 988  YVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTA 1044

Query: 633  NIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQIL 672
            N+ + G+++LF L K DL E L  YP+++ +L +K +++L
Sbjct: 1045 NVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRML 1084


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  303 bits (777), Expect = 3e-82
 Identities = 161/441 (36%), Positives = 260/441 (58%), Gaps = 14/441 (3%)

Query: 234 YYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDM-FVRTRTGY 292
           Y  WL  +TL   +N   +  R  F    +D + YWLI D + DI+YL DM F++ R  +
Sbjct: 218 YLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQF 277

Query: 293 LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFE 352
           +  G ++ +  +L   Y+++ +F+LDV S+IP D+ Y   G+N P  R NR+L+++  FE
Sbjct: 278 VRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYTSFFE 336

Query: 353 FFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFG 412
           F    E+  +   I+R+     Y++ I+H NACV+Y  S   G G   WVY    D E  
Sbjct: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY----DGE-- 390

Query: 413 RLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNM 472
               +Y+   YW+  TL TIG  P P    E VF +++F  GV +F++++G +  +I   
Sbjct: 391 --GNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448

Query: 473 NAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRA 532
            A +  F+A +D    YM+  ++ K ++KRV  W++Y W +++ +DE ++LK LP  ++ 
Sbjct: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508

Query: 533 EIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGK 592
            +AI+V+   + KV +F  C+  ++ +++L+L+  +Y PGD++CKKG+IG+EMYIIK G+
Sbjct: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568

Query: 593 LAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 651
           + V+   DG    V L  GS FGEIS+L   G   GNRRTAN+ + G+++L  L K  L 
Sbjct: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQ 625

Query: 652 EALTEYPDAKTMLEEKGKQIL 672
           E L  YPD++ +L +K + +L
Sbjct: 626 EILVHYPDSERILMKKARVLL 646



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 13/48 (27%), Positives = 31/48 (64%)

Query: 174 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 221
           K+++  +KK  S+   E   + E K+K+ + ++K+ E+K K+ ++++K
Sbjct: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDK 742



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 17/54 (31%), Positives = 33/54 (61%), Gaps = 1/54 (1%)

Query: 169 QEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEK-KKKEEKSKDKKEEEK 221
           +E   +KK+  E   +   +NE+K    + K+K++++K K+ E+K K ++ EEK
Sbjct: 696 REQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 14/48 (29%), Positives = 28/48 (58%)

Query: 174 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 221
           K K+++  + K + +   +   E + K+K+ E K+KE + K K+ E+K
Sbjct: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDK 740



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 18/53 (33%), Positives = 32/53 (60%), Gaps = 2/53 (3%)

Query: 172 EEKKKKKKEKKSKSDDKNENKN-DPEKKKKKKDKEKKKKEEKSKDK-KEEEKK 222
           E+  +KK+  +   ++  EN++   E + K+K+ E K KE + KDK +E E+K
Sbjct: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 15/66 (22%), Positives = 35/66 (53%)

Query: 160 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE 219
           N      + +E E+K+K+ ++K+ +++DK +   D +K ++ ++K   + E  +     E
Sbjct: 705 NSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVE 764

Query: 220 EKKEVV 225
           E+   V
Sbjct: 765 EEPHSV 770



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 12/44 (27%), Positives = 28/44 (63%)

Query: 179 KEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKK 222
           K K+ ++  K EN    E++ K+ + ++K+ E+K K+ +++ K+
Sbjct: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKE 736


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  178 bits (451), Expect = 2e-44
 Identities = 133/526 (25%), Positives = 258/526 (49%), Gaps = 53/526 (10%)

Query: 211 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 268
           +K+ +K++E  K     +I P  +  + W   + + ++ N  ++     F   Q+     
Sbjct: 117 QKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTT--TP 174

Query: 269 WLILDYVSDIVYLIDMFVRTRTGYLEQG---LLVKEELKLINKYKSNLQFKLDVLSLIPT 325
           W+I +  SD V+L+D+ +  RTG + +    +++  ++  +N  KS   F +D +S IP 
Sbjct: 175 WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKS--WFVVDFISSIPV 232

Query: 326 DLLY-----------FKLGWNYPEIR------LNRLLRFSRMFEFFQRTE-----TRTNY 363
           D ++           +K       +R      L RLLR SR+  +  + E     T    
Sbjct: 233 DYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 292

Query: 364 PNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLY 423
             + RI NL+  ++++ HW+ C+ + +     F  D WV   +N+       ++Y Y+L+
Sbjct: 293 SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV--SLNEMVNDSWGKQYSYALF 350

Query: 424 WSTLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQAR 482
            +   +  IG     PV  S+    ++  ++G   +A  VG+  ++I +++++R ++Q +
Sbjct: 351 KAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEK 410

Query: 483 IDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDT 542
              ++QYM F  +  DM +++  ++++ +   K  DE+ +L  L D LR EI        
Sbjct: 411 YKQVEQYMSFHKLPADMRQKIHDYYEHRYQG-KIFDEENILNELNDPLREEIVNFNCRKL 469

Query: 543 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602
           +  + +FA+ +   +  ++ KL+ +V+ PGDYI ++G +G++MY I+ G   V+     +
Sbjct: 470 VATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS--S 527

Query: 603 QFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKT 662
           + + L+DGSYFGEI +L  KG     RRTA++++  Y  L+ LS D+  E L EYP  + 
Sbjct: 528 KEMKLTDGSYFGEICLLT-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 581

Query: 663 MLEE----------KGKQILMKDGLLDLNIANAGSDPKDLEEKVTR 698
             E           K   IL++    DLN     +   ++ +++ +
Sbjct: 582 AFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVK 627


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  175 bits (444), Expect = 1e-43
 Identities = 124/483 (25%), Positives = 241/483 (49%), Gaps = 43/483 (8%)

Query: 211 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 268
           +K+ ++++E  K     +I P  +  + W   + L ++ N  ++     F   + +    
Sbjct: 237 QKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTP 294

Query: 269 WLILDYVSDIVYLIDMFVRTRTGYL--EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTD 326
           W++ + VSD  +LID+ +  RTG +  +   ++ +  ++  KY  +  F +D +S IP D
Sbjct: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVD 353

Query: 327 LLYFKLGWNYPE-----------------IRLNRLLRFSRMFEFFQRTE-----TRTNYP 364
            ++  +                       + L RLLR SR+  +  + E     T     
Sbjct: 354 YIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLAS 413

Query: 365 NIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW 424
            + RI NL+  ++++ HW+ C+ + +     F +D WV   IN+       ++Y Y+L+ 
Sbjct: 414 AVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWV--SINNMVNNSWGKQYSYALFK 471

Query: 425 STLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARI 483
           +   +  IG     PV  S+    ++  ++G   +A  +G+  ++I +++++R ++Q + 
Sbjct: 472 AMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY 531

Query: 484 DAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTL 543
             ++QYM F  +  D  +R+  ++++ +  K   DE+ +L  L + LR EI IN +   L
Sbjct: 532 KQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKM-FDEESILGELSEPLREEI-INFNCRKL 589

Query: 544 -KKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVT 602
              + +FA+ +   +  ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+      
Sbjct: 590 VASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--N 647

Query: 603 QFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKT 662
           +   L+DGSYFGEI +L         RRTA++++  Y  L+ LS D+  E L EYP  + 
Sbjct: 648 KETKLADGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701

Query: 663 MLE 665
             E
Sbjct: 702 AFE 704


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  166 bits (419), Expect = 1e-40
 Identities = 120/481 (24%), Positives = 233/481 (48%), Gaps = 39/481 (8%)

Query: 211 EKSKDKKEEEKKEVV--VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEY 268
           +K+ ++++E  K     +I P  +  + W F + L ++ N  ++     F   + +    
Sbjct: 186 QKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAP 243

Query: 269 WLILDYVSDIVYLIDMFVRTRTGY-LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDL 327
           W++ + VSD  +L+D+ +  RTG  +E    +  + + I K      F +D +S IP D 
Sbjct: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303

Query: 328 LY-----------FKLGWNYPEIR------LNRLLRFSRMFEFFQRTE-----TRTNYPN 365
           ++           +K       +R      L RLLR SR+  +  + E     T      
Sbjct: 304 IFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 363

Query: 366 IFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWS 425
           + RI NL+  ++++ HW+ C+ + +     F  + WV   IN       +  Y ++L+ +
Sbjct: 364 VMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWV--SINGMVNHSWSELYSFALFKA 421

Query: 426 TLTLTTIGE-TPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARID 484
              +  IG     P   ++    ++  ++G   +A  +G+  ++I +++++R ++Q +  
Sbjct: 422 MSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYK 481

Query: 485 AIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLK 544
            ++QYM F  +  D  +++  ++++ +  K   DE  +L  L   LR EI        + 
Sbjct: 482 QVEQYMSFHKLPADFRQKIHDYYEHRYQGKM-FDEDSILGELNGPLREEIVNFNCRKLVA 540

Query: 545 KVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQF 604
            + +FA+ +   +  ++ KL+ +V+ PGDYI ++G IG++MY I+ G ++V+      + 
Sbjct: 541 SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKE 598

Query: 605 VVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTML 664
           + LSDGSYFGEI +L         RRTA++++  Y  L+ LS D+  E L EYP  +   
Sbjct: 599 MKLSDGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 652

Query: 665 E 665
           E
Sbjct: 653 E 653


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  163 bits (412), Expect = 6e-40
 Identities = 120/490 (24%), Positives = 232/490 (47%), Gaps = 39/490 (7%)

Query: 226 VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMF 285
           +I P  +  + W   + L ++ N  ++     F   + +    W++ + +SD  +L+D+ 
Sbjct: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVLSDTFFLLDLV 142

Query: 286 VRTRTGYL-EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWN-------YP 337
           +  RTG + E+G  +    + I        F +D++S IP D ++  +          Y 
Sbjct: 143 LNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYK 202

Query: 338 EIR------------LNRLLRFSRMFEFFQRTE-----TRTNYPNIFRISNLVMYIVIII 380
             R            L RLLR SR+  +  + E     T      + RI NL+  ++++ 
Sbjct: 203 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLC 262

Query: 381 HWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGE-TPPPV 439
           HW+ C+ + +     F  D WV   IN        R+Y ++L+ +   +  IG     PV
Sbjct: 263 HWDGCLQFLVPMLQDFPPDCWV--SINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPV 320

Query: 440 RDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDM 499
              +    ++  ++G   +A  +G+  ++I +++++R ++Q +   ++QYM F  +  D 
Sbjct: 321 GMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADT 380

Query: 500 EKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVE 559
            +R+ +++++ +  K   DE+ +L  L + LR EI        +  + +FA  +   +  
Sbjct: 381 RQRIHEYYEHRYQGKM-FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTA 439

Query: 560 LVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISIL 619
           ++ KL+ +V+ PGD + ++G +GR+MY I+ G L+V+A     +   L+DGSYFGEI +L
Sbjct: 440 VLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEICLL 497

Query: 620 NIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLD 679
                    RRTA++++  Y  L+ LS D     L E+P  +   E      L++ G  +
Sbjct: 498 ------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKN 551

Query: 680 LNIANAGSDP 689
             +    S+P
Sbjct: 552 SILQRKRSEP 561


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  162 bits (409), Expect = 1e-39
 Identities = 139/556 (25%), Positives = 256/556 (46%), Gaps = 47/556 (8%)

Query: 142 KGGPSQREQYLPGAIALFNVNNSSNKDQEPE------EKKKKKKEKKSKSDDKNENKNDP 195
           KG  +  +  L G+ +  N+N  S  ++ P+      E K +KK     S DK      P
Sbjct: 304 KGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIA--P 361

Query: 196 EKKKKKKDKEKKKKEEKS--KDKKEEEKKEVVVIDPSGNTYYN-----WLFCITLPVMYN 248
           + K +  +  +K  +  S   D   E K +   I+     +Y+     W + I L V+Y 
Sbjct: 362 KVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYT 421

Query: 249 WTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVRTRTGYLEQGLLV 299
                  A F     +E +     Y      ++D + DI+++ID+ +  RT Y+ Q   V
Sbjct: 422 AIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEV 481

Query: 300 KEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLLRFSRMFEFFQRT 357
             +   I  +     F +D+++ IP DLL F  G +     I L +  R  R+    ++ 
Sbjct: 482 VSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKL 541

Query: 358 ETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFGNDTWV-----YP 404
           +  + Y     +  L+    +I HW AC++Y+I           IG+ +         Y 
Sbjct: 542 DRYSEYGAAV-LMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYN 600

Query: 405 DINDPEFGRLARKYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVG 463
           D +      +  KYV +LY++  +LT++G     P  +SE +F +   LIG L++A+I G
Sbjct: 601 DSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFG 660

Query: 464 NIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVL 523
           N+ ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + WT    +D   VL
Sbjct: 661 NVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVL 720

Query: 524 KYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGR 583
           K  P+ L+A+I ++++   L+  + F     G L  L +K +     PGD +   GD+  
Sbjct: 721 KGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLT 780

Query: 584 EMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLF 643
            +Y +  G + ++ DD V    +L     FGE+  L  K  K+     A+++++ Y DL 
Sbjct: 781 ALYFLSRGSIEILKDDIVV--AILGKNDIFGEMVHLYAKPGKS----NADVRALTYCDLH 834

Query: 644 CLSKDDLMEALTEYPD 659
            + ++DL+E L  YP+
Sbjct: 835 KIQREDLLEVLDMYPE 850


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  157 bits (396), Expect = 5e-38
 Identities = 117/447 (26%), Positives = 216/447 (48%), Gaps = 32/447 (7%)

Query: 237 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 287
           W + I L V+Y        A F     DE +     Y      ++D + DI++++D+ + 
Sbjct: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318

Query: 288 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 345
            RT Y+     V    + I  +     F +D+++ IP DLL F+ G +     I L +  
Sbjct: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378

Query: 346 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFG 397
           R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I           IG+ 
Sbjct: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWL 437

Query: 398 NDTWVYP----DINDPEFGRLAR-KYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDF 451
           +   V      + +DP  G   + KYV +LY++  +LT++G     P  +SE VF +   
Sbjct: 438 DSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVM 497

Query: 452 LIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLW 511
           LIG L++A+I GN+ ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + W
Sbjct: 498 LIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 557

Query: 512 TNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSP 571
           +    +D   VLK  P+ L+A+I +++H   L+    F+    G L  L +K +     P
Sbjct: 558 SYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPP 617

Query: 572 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 631
           GD +   GD+   +Y I  G + ++ DD V    +L     FGE   L+ +  K+    +
Sbjct: 618 GDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----S 671

Query: 632 ANIKSIGYSDLFCLSKDDLMEALTEYP 658
           A+++++ Y DL  + + DL+E L  YP
Sbjct: 672 ADVRALTYCDLHKIQRADLLEVLDMYP 698


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  154 bits (390), Expect = 2e-37
 Identities = 128/549 (23%), Positives = 250/549 (45%), Gaps = 56/549 (10%)

Query: 154 GAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKK------------KK 201
           G + LF  +     D + +   + KKE K K   +     D  +++            ++
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR 180

Query: 202 KDKEKKK--------KEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVI 253
           ++K K K        K    + K  + KK   ++         W + I L   Y    V 
Sbjct: 181 REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP 240

Query: 254 ARACF---DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYK 310
              CF   D+L +       + D   +I+++ID+ +  RT Y+ +   V  E + I  + 
Sbjct: 241 YNVCFIGNDDLSTT--RSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298

Query: 311 SNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLL---RFSRMFEFFQRTETRTNYPNIF 367
               F +D+++ +P DLLY    +N   + L  LL   R  R+    Q+ +  + +  I 
Sbjct: 299 VTTWFIIDLIAALPFDLLY---AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355

Query: 368 RISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVYP---DINDPEFGR----- 413
            ++ L+    ++ HW AC++Y I K     N        W++     +  P +G      
Sbjct: 356 -LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG 414

Query: 414 --LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNIGSMIS 470
             +   Y+ +LY++  +LT++G        D+E +F +   LIG L+ A + GN+ ++I 
Sbjct: 415 PSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQ 474

Query: 471 NMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKL 530
            M +  + +  R   +K ++   ++ + +++R++++F   W+    +D  E+LK  PD+L
Sbjct: 475 RMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDEL 534

Query: 531 RAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKE 590
           R++I ++++ + L ++ +F     G L  L L ++    +PG+Y+ ++GD  + +Y +  
Sbjct: 535 RSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCS 593

Query: 591 GKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDL 650
           G + V+ D  V    +L  G   G  + L+IK      +  A++K++ Y DL C+    L
Sbjct: 594 GSMEVLKDSMV--LAILGKGDLIG--ANLSIKDQVI--KTNADVKALTYCDLQCIILKGL 647

Query: 651 MEALTEYPD 659
            E L  YP+
Sbjct: 648 FEVLDLYPE 656


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  148 bits (373), Expect = 2e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 114 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 173

Query: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 174 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 231

Query: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 232 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 291

Query: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 292 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 351

Query: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 352 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 411

Query: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 412 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 469

Query: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 659
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 470 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 507


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  148 bits (373), Expect = 2e-35
 Identities = 101/402 (25%), Positives = 196/402 (48%), Gaps = 21/402 (5%)

Query: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513

Query: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571

Query: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631

Query: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691

Query: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751

Query: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617
             L +K +     PGD +   GD+   +Y I  G + ++  D V    +L     FGE  
Sbjct: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVV--AILGKNDIFGEPL 809

Query: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPD 659
            L  +  K+      +++++ Y DL  + +DDL+E L  YP+
Sbjct: 810 NLYARPGKS----NGDVRALTYCDLHKIHRDDLLEVLDMYPE 847


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  146 bits (369), Expect = 6e-35
 Identities = 111/449 (24%), Positives = 215/449 (47%), Gaps = 32/449 (7%)

Query: 237 WLFCITLPVMYNWTMVIARACF--DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLE 294
           W   I L   Y    V    CF  D+       + L+ D   ++++++D+ +  RT Y+ 
Sbjct: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288

Query: 295 QGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFF 354
           Q   V    + I  +     F +D+++ +P DLLY         + L + +R  R+    
Sbjct: 289 QSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLL 348

Query: 355 QRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVY----- 403
           Q+ E R +  +   ++ L+    ++ HW AC++Y I +     ND       W++     
Sbjct: 349 QKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKR 407

Query: 404 ---PDINDPEFGRLARK-YVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIF 458
              P +N    G   R  Y+ +LY++  +LT++G        D+E +F +   LIG L+ 
Sbjct: 408 LEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467

Query: 459 ATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD 518
           A + GN+ ++I  M + R+ + +R+  +K ++    + + +++R++++F   W     +D
Sbjct: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527

Query: 519 EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKK 578
             E+L+  PD+LRA+IA++++ + L ++ +F     G L  L L ++    +PG+Y+ ++
Sbjct: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586

Query: 579 GDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG--------NRR 630
           GD  +  Y +  G L V+ D+ V    +L  G   G  + +   G + G         + 
Sbjct: 587 GDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVLKT 642

Query: 631 TANIKSIGYSDLFCLSKDDLMEALTEYPD 659
           +A++K++ Y  L  LS   L E L  YP+
Sbjct: 643 SADVKALTYCGLQQLSSRGLAEVLRLYPE 671


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  145 bits (365), Expect = 2e-34
 Identities = 122/521 (23%), Positives = 231/521 (44%), Gaps = 44/521 (8%)

Query: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277

Query: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRV 337

Query: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT-------WVY 403
               ++ +    Y     +  LV    +  HW AC++YSI     F  DT       W+Y
Sbjct: 338 A---RKLDHYIEYGAAVLVL-LVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 393

Query: 404 P---DINDP-----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFV 447
               DI  P           E G      Y+ SLY++  +LT++G     P  D E +F 
Sbjct: 394 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 453

Query: 448 VVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWF 507
           V   +IG L++ATI GN+ ++   M A    +   +++++ ++    V K + +RV+ + 
Sbjct: 454 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 513

Query: 508 DYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQ 567
              W+  + +D ++VL+  P  +RA+I ++++    K+   F     G L  L ++ Q  
Sbjct: 514 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 573

Query: 568 VYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG 627
             +PGD I   G+    +  +  G L V+ DD V    +L  G  FG++       +++ 
Sbjct: 574 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS- 630

Query: 628 NRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGS 687
               AN++++ Y DL  + +D L + L  Y           + +++   L    +    S
Sbjct: 631 ---CANVRALTYCDLHVIKRDALQKVLEFY---TAFSHSFSRNLILTYNLRKRIVFRKIS 684

Query: 688 DPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRL 728
           D K  EE+  + +    L+      +   ++  +Q+ + RL
Sbjct: 685 DVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARL 725


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  144 bits (363), Expect = 3e-34
 Identities = 126/497 (25%), Positives = 218/497 (43%), Gaps = 43/497 (8%)

Query: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 274

Query: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334

Query: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 403
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 335 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 390

Query: 404 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 448
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 391 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 450

Query: 449 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 508
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 451 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 510

Query: 509 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 568
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 511 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 570

Query: 569 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 628
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 571 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 626

Query: 629 RRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSD 688
              AN++++ Y DL  + ++ L++ L  Y           + + +   L    I    SD
Sbjct: 627 --CANVRALTYCDLHIIKREALLKVLDFY---TAFANSFSRNLTLTCNLRKRIIFRKISD 681

Query: 689 PKDLEEKVTRMEGSVDL 705
            K  EE+  R +  V L
Sbjct: 682 VKKEEEERLRQKNEVTL 698


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  142 bits (359), Expect = 9e-34
 Identities = 116/449 (25%), Positives = 203/449 (45%), Gaps = 40/449 (8%)

Query: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 159 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 216

Query: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 217 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 276

Query: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 403
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 277 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 332

Query: 404 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 448
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 333 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 392

Query: 449 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 508
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 393 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 452

Query: 509 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 568
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 453 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 512

Query: 569 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 628
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 513 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 568

Query: 629 RRTANIKSIGYSDLFCLSKDDLMEALTEY 657
              AN++++ Y DL  + ++ L++ L  Y
Sbjct: 569 --CANVRALTYCDLHIIKREALLKVLDFY 595


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  139 bits (349), Expect = 1e-32
 Identities = 108/433 (24%), Positives = 195/433 (45%), Gaps = 57/433 (13%)

Query: 237 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 287
           W + I L V+Y        A F     DE +     Y      ++D + DI++++D+ + 
Sbjct: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318

Query: 288 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 345
            RT Y+     V    + I  +     F +D+++ IP DLL F+ G +     I L +  
Sbjct: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378

Query: 346 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPD 405
           R  R+    ++ +  + Y     +  L+    +I HW AC+    S  +GFGN   V P+
Sbjct: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACICSLTS--VGFGN---VSPN 432

Query: 406 INDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNI 465
            N                                  SE VF +   LIG L++A+I GN+
Sbjct: 433 TN----------------------------------SEKVFSICVMLIGSLMYASIFGNV 458

Query: 466 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 525
            ++I  + +  A +  ++  +K+++ F  +   + +R+ ++F + W+    +D   VLK 
Sbjct: 459 SAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKG 518

Query: 526 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 585
            P+ L+A+I +++H   L+    F+    G L  L +K +     PGD +   GD+   +
Sbjct: 519 FPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTL 578

Query: 586 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 645
           Y I  G + ++ DD V    +L     FGE   L+ +  K+    +A+++++ Y DL  +
Sbjct: 579 YFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----SADVRALTYCDLHKI 632

Query: 646 SKDDLMEALTEYP 658
            + DL+E L  YP
Sbjct: 633 QRADLLEVLDMYP 645


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  137 bits (345), Expect = 4e-32
 Identities = 124/548 (22%), Positives = 234/548 (42%), Gaps = 71/548 (12%)

Query: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277

Query: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF---------------KLGWN------ 335
             V  + KLI        F +D+LS +P D++                 K+G+       
Sbjct: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPP 337

Query: 336 ------------YPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWN 383
                       +  +++ RLLR  R+    ++ +    Y     +  LV    +  HW 
Sbjct: 338 LEGRESQGISSLFSSLKVVRLLRLGRVA---RKLDHYIEYGAAVLVL-LVCVFGLAAHWM 393

Query: 384 ACVFYSISKAIGFGNDT-------WVYP---DINDP-----------EFGRLARK-YVYS 421
           AC++YSI     F  DT       W+Y    DI  P           E G      Y+ S
Sbjct: 394 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 453

Query: 422 LYWSTLTLTTIG-ETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQ 480
           LY++  +LT++G     P  D E +F V   +IG L++ATI GN+ ++   M A    + 
Sbjct: 454 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 513

Query: 481 ARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHL 540
             +++++ ++    V K + +RV+ +    W+  + +D ++VL+  P  +RA+I ++++ 
Sbjct: 514 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 573

Query: 541 DTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 600
              K+   F     G L  L ++ Q    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 574 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 633

Query: 601 VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDA 660
           V    +L  G  FG++       +++     AN++++ Y DL  + +D L + L  Y   
Sbjct: 634 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFY--- 684

Query: 661 KTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESM 720
                   + +++   L    +    SD K  EE+  + +    L+      +   ++  
Sbjct: 685 TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRF 744

Query: 721 QQKLKQRL 728
           +Q+ + RL
Sbjct: 745 RQQKEARL 752


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  137 bits (344), Expect = 5e-32
 Identities = 105/434 (24%), Positives = 200/434 (46%), Gaps = 54/434 (12%)

Query: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLY- 329
           + D   ++++++D+ +  RT ++ +   V    K I  +     F LDV++ +P DLL+ 
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHA 322

Query: 330 FKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYS 389
           FK+   Y    L + +R  R+     R +  + Y  +  ++ L+    ++ HW ACV++ 
Sbjct: 323 FKVNV-YFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380

Query: 390 ISKA-----------IGF---------------------GNDTWVYPDINDPEFGR---- 413
           I +            IG+                     GN +    + +          
Sbjct: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440

Query: 414 -------LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNI 465
                  L   Y+ SLY++  +LT++G        D+E +F +   LIG L+ A + GN+
Sbjct: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500

Query: 466 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 525
            ++I  M A R  + +R   ++ Y+    + K +++R++++F   W     +D  E+L+ 
Sbjct: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560

Query: 526 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 585
           LPD+LRA+IA+++H + L ++ +F     G L  L L L+P   +PG+Y+  +GD  + +
Sbjct: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619

Query: 586 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 645
           Y +  G + V+   G T   +L  G   G      +   +   +  A++K + Y  L CL
Sbjct: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673

Query: 646 SKDDLMEALTEYPD 659
               L ++L  YP+
Sbjct: 674 QLAGLHDSLALYPE 687


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  130 bits (328), Expect = 3e-30
 Identities = 93/388 (23%), Positives = 185/388 (47%), Gaps = 19/388 (4%)

Query: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF 330
           ++D + DI++++D+ +  RT Y+     V      I  +     F +D+++ IP DLL F
Sbjct: 454 VVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIF 513

Query: 331 KLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSI 390
             G +   I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I
Sbjct: 514 GSG-SEELIGLLKTARLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAI 571

Query: 391 SKAIGFGNDT---WVY-------PDINDPEFG--RLARKYVYSLYWSTLTLTTIG-ETPP 437
                   D+   W++          N    G   +  KYV +LY++  +LT++G     
Sbjct: 572 GNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVS 631

Query: 438 PVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 497
           P  +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +++++ F  +  
Sbjct: 632 PNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPN 691

Query: 498 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLL 557
            + +R+ ++F + W+    +D   VLK  P+ L+A+I ++++   L+  + F     G L
Sbjct: 692 PLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCL 751

Query: 558 VELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEIS 617
             L +K +     PGD +   GD+   +Y I  G + ++  D V   + +  G+  G   
Sbjct: 752 RALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGAGTG--- 808

Query: 618 ILNIKGSKAGNRRTANIKSIGYSDLFCL 645
            L +  + +      N++S+G     CL
Sbjct: 809 -LEMPSAASRGASLLNMQSLGLWTWDCL 835


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  127 bits (320), Expect = 3e-29
 Identities = 102/393 (25%), Positives = 177/393 (45%), Gaps = 34/393 (8%)

Query: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 274

Query: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334

Query: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 403
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 335 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 390

Query: 404 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 448
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 391 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 450

Query: 449 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 508
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 451 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 510

Query: 509 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 568
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 511 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 570

Query: 569 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGV 601
            +PGD I   G+    +  +  G L V+ DD V
Sbjct: 571 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  103 bits (256), Expect = 8e-22
 Identities = 103/439 (23%), Positives = 194/439 (44%), Gaps = 41/439 (9%)

Query: 118 ASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPE----- 172
           AS+  + E    H +  F  +   +G  +  +  L G+ +  N+N  S  ++ P+     
Sbjct: 273 ASSVHDIEGFGVHPKNIFRDRHASEGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNF 332

Query: 173 -EKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKS--KDKKEEEKKEVVVIDP 229
            E K +KK     S DK      P+ K +  +  +K  +  S   D   E K +   I+ 
Sbjct: 333 SEVKTEKKNSSPPSSDKTIIA--PKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINK 390

Query: 230 SGNTYYN-----WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYV 275
               +Y+     W + I L V+Y        A F     +E +     Y      ++D +
Sbjct: 391 FTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLI 450

Query: 276 SDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWN 335
            DI+++ID+ +  RT Y+ Q   V  +   I  +     F +D+++ IP DLL F  G +
Sbjct: 451 VDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSD 510

Query: 336 YPE--IRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA 393
                I L +  R  R+    ++ +  + Y     +  L+    +I HW AC++Y+I   
Sbjct: 511 ETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAV-LMLLMCIFALIAHWLACIWYAIGNV 569

Query: 394 --------IGFGNDTWV-----YPDINDPEFGRLARKYVYSLYWSTLTLTTIG-ETPPPV 439
                   IG+ +         Y D +      +  KYV +LY++  +LT++G     P 
Sbjct: 570 ERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPN 629

Query: 440 RDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDM 499
            +SE +F +   LIG L++A+I GN+ ++I  + +  A +  ++  +K+++ F  +   +
Sbjct: 630 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPL 689

Query: 500 EKRVIKWFDYLWTNKKTVD 518
            +R+ ++F + WT    +D
Sbjct: 690 RQRLEEYFQHAWTYTNGID 708


>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 170

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 28/68 (41%), Positives = 44/68 (64%)

Query: 156 IALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKD 215
           + L  +     K ++ +EKKKKKK+KK K   K + K   +KKKKKK K K+K++ K K 
Sbjct: 94  LPLHGLPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKK 153

Query: 216 KKEEEKKE 223
           K++++KK+
Sbjct: 154 KRKKKKKK 161



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 27/64 (42%), Positives = 41/64 (64%)

Query: 169 QEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVID 228
           Q  E+K+K+K++KK K   K + K   +KKKKKK K+KKK++ K K K++ +KK      
Sbjct: 101 QREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKK 160

Query: 229 PSGN 232
            +GN
Sbjct: 161 KTGN 164



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/55 (41%), Positives = 38/55 (69%)

Query: 169 QEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKE 223
           ++ ++KKKKKK+KK K   K + K   +KK+K+K K K+K+++K K KK++   E
Sbjct: 111 EKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGNE 165



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 22/58 (37%), Positives = 37/58 (63%)

Query: 167 KDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEV 224
           K ++ ++KKKKKK+KK K   K + K    K+K+K+ +++KKK +K K K   E  ++
Sbjct: 112 KKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGNEGAKI 169


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 23/57 (40%), Positives = 47/57 (82%)

Query: 167 KDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKE 223
           K++  E++K+K+K+KK+K  +K + K + EKK+K+K K+KK++EE+ ++++EEE+++
Sbjct: 30  KEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEK 86



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 25/57 (43%), Positives = 43/57 (75%)

Query: 167 KDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKE 223
           K +E  ++K+K+KEKK K+ +  + K   E++KK+K K KKKKEE+ ++++EEE++E
Sbjct: 28  KRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEE 84



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 31/117 (26%), Positives = 61/117 (52%), Gaps = 16/117 (13%)

Query: 113 EDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPE 172
           E +++  T E  E E    +     K  RK    +++                 K++E E
Sbjct: 9   ETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKK----------TKETEKRKEKEEE 58

Query: 173 EKKKKKKEKKSKSDDKNENKNDPEKKKKKKD------KEKKKKEEKSKDKKEEEKKE 223
           EKK+K+K KK K +++ E + + E+++K+++      + KKKK+ + K+++EE+KK+
Sbjct: 59  EKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKK 115



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 27/61 (44%), Positives = 43/61 (70%), Gaps = 10/61 (16%)

Query: 172 EEKKKKKKE-------KKSKSDDKNENKNDPEKKKKKKDKEKKKKE---EKSKDKKEEEK 221
           ++KKKKKKE       ++++ +++ E K   ++K+K+K+KEKKKK    EK K+K+EEEK
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60

Query: 222 K 222
           K
Sbjct: 61  K 61



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 21/52 (40%), Positives = 39/52 (75%)

Query: 172 EEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKE 223
           ++KKKKK+ ++++  ++ E + + E K+K+K KEK+K++EK K  KE EK++
Sbjct: 2   KKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRK 53



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 20/51 (39%), Positives = 38/51 (74%)

Query: 173 EKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKE 223
           +KKKKKK++  ++++  E + + EK+ K+K+K K+K++EK K KK +E ++
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEK 51


>gi|148664240 hypothetical protein LOC146556 isoform 1 [Homo
           sapiens]
          Length = 440

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 30/54 (55%), Positives = 36/54 (66%), Gaps = 7/54 (12%)

Query: 21  LHLPDSSDFQLI-------FVFLVEMGFHHVGQAGLELLISSDLPTSASQSAGI 67
           L LP S D++ +       ++FLVE GFHHV  AGLELLIS D PTS SQS G+
Sbjct: 387 LILPSSWDYRSVPPYLANFYIFLVETGFHHVAHAGLELLISRDPPTSGSQSVGL 440


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,972,637
Number of Sequences: 37866
Number of extensions: 1316629
Number of successful extensions: 44212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 833
Number of HSP's successfully gapped in prelim test: 451
Number of HSP's that attempted gapping in prelim test: 15985
Number of HSP's gapped (non-prelim): 14261
length of query: 759
length of database: 18,247,518
effective HSP length: 110
effective length of query: 649
effective length of database: 14,082,258
effective search space: 9139385442
effective search space used: 9139385442
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.