Search of human proteins with 114145479

Search of human proteins with 114145479

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
         (596 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...  1187   0.0  
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...  1022   0.0  
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...   579   e-165
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...   558   e-159
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...   555   e-158
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               122   1e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   105   2e-22
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   105   2e-22
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]           94   3e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]           94   3e-19
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    92   2e-18
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...    89   1e-17
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    84   3e-16
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...    84   3e-16
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...    84   3e-16
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    82   1e-15
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]        78   3e-14
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]        78   3e-14
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]        78   3e-14
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              77   6e-14
gi|222080070 pleckstrin homology domain-containing family G memb...    75   1e-13
gi|222080068 pleckstrin homology domain-containing family G memb...    75   1e-13
gi|222080066 pleckstrin homology domain-containing family G memb...    75   1e-13
gi|39930351 dynamin binding protein [Homo sapiens]                     74   3e-13
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    74   3e-13
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    74   4e-13
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             73   6e-13
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    73   8e-13
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    73   8e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    73   8e-13

>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 1187 bits (3071), Expect = 0.0
 Identities = 596/596 (100%), Positives = 596/596 (100%)

Query: 1   MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN 60
           MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN
Sbjct: 1   MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN 60

Query: 61  WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI 120
           WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI
Sbjct: 61  WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI 120

Query: 121 QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY 180
           QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY
Sbjct: 121 QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY 180

Query: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT 240
           EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT
Sbjct: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT 240

Query: 241 KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR 300
           KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR
Sbjct: 241 KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR 300

Query: 301 KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES 360
           KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES
Sbjct: 301 KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES 360

Query: 361 ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE 420
           ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE
Sbjct: 361 ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE 420

Query: 421 RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT 480
           RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT
Sbjct: 421 RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT 480

Query: 481 LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST 540
           LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST
Sbjct: 481 LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST 540

Query: 541 VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 596
           VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
Sbjct: 541 VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 596


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
           [Homo sapiens]
          Length = 542

 Score = 1022 bits (2642), Expect = 0.0
 Identities = 516/529 (97%), Positives = 520/529 (98%)

Query: 68  KRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG 127
           KR  +  DV + S  + +EPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG
Sbjct: 14  KRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRG 73

Query: 128 DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ 187
           DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ
Sbjct: 74  DHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQ 133

Query: 188 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 247
           DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE
Sbjct: 134 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 193

Query: 248 QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF 307
           QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF
Sbjct: 194 QIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSF 253

Query: 308 LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID 367
           LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID
Sbjct: 254 LDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID 313

Query: 368 KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY 427
           KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY
Sbjct: 314 KLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVY 373

Query: 428 RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF 487
           RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF
Sbjct: 374 RQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVF 433

Query: 488 HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV 547
           HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV
Sbjct: 434 HKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQV 493

Query: 548 EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 596
           EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
Sbjct: 494 EVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV 542


>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  579 bits (1492), Expect = e-165
 Identities = 283/455 (62%), Positives = 365/455 (80%), Gaps = 2/455 (0%)

Query: 47  RRGSSFTFLTPGPNWDFT-LKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLI 105
           +R ++F        W+F   KRK+  +D+D VSL SLD+ EPSNKRV+PL+RVTSLANLI
Sbjct: 25  QRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLI 84

Query: 106 SPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITM 164
            PV+   ++RF QT+Q S + R + R    A +  SR+  P+  KRR S LWSE  D+ +
Sbjct: 85  PPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCV 144

Query: 165 KESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDS 224
            + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDPMLKLSIM+E+EL  IFG LDS
Sbjct: 145 NQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDS 204

Query: 225 YIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDP 284
            IPLHE+LL+++ +  KPDG+ E +G ILV WLP L++Y  YCSNQ+AAKALLD KKQD 
Sbjct: 205 LIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDH 264

Query: 285 RVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAIL 344
           RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+EIL+HTP ++PD Q LE+AI 
Sbjct: 265 RVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 324

Query: 345 IIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIF 404
           IIQG++++IN K GESEC+YY ++L YL+E Q+D  I++S+VL CHGEL++  G KL++F
Sbjct: 325 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVF 384

Query: 405 LFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKN 464
           LFQ++LV+TR VT NE+  YQ+YRQPIPV++L+LEDLQDG+VR+GGS RGAFSN+E+ KN
Sbjct: 385 LFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKN 444

Query: 465 IFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 499
            FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 445 FFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 479


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
           sapiens]
          Length = 526

 Score =  558 bits (1438), Expect = e-159
 Identities = 273/437 (62%), Positives = 351/437 (80%), Gaps = 1/437 (0%)

Query: 64  TLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-S 122
           T+KR     +    S  + D +EPSNKRV+PL+RVTSLANLI PV+   ++RF QT+Q S
Sbjct: 11  TVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRS 70

Query: 123 FTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEM 182
            + R + R    A +  SR+  P+  KRR S LWSE  D+ + + LT++EI+RQEAI+E+
Sbjct: 71  ISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFEL 130

Query: 183 SRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP 242
           S+GE+DLIEDLKLA+KAYHDPMLKLSIM+E+EL  IFG LDS IPLHE+LL+++ +  KP
Sbjct: 131 SQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP 190

Query: 243 DGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKL 302
           DG+ E +G ILV WLP L++Y  YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKL
Sbjct: 191 DGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKL 250

Query: 303 DLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESEC 362
           DLW+FLDIPRSRLVKYPLLL+EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC
Sbjct: 251 DLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESEC 310

Query: 363 QYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERH 422
           +YY ++L YL+E Q+D  I++S+VL CHGEL++  G KL++FLFQ++LV+TR VT NE+ 
Sbjct: 311 RYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQL 370

Query: 423 SYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQ 482
            YQ+YRQPIPV++L+LEDLQDG+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQ
Sbjct: 371 CYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQ 430

Query: 483 ANDVFHKQQWFNCIRAA 499
           AND F+KQQW NCIR A
Sbjct: 431 ANDTFNKQQWLNCIRQA 447


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
           [Homo sapiens]
          Length = 532

 Score =  555 bits (1431), Expect = e-158
 Identities = 268/416 (64%), Positives = 343/416 (82%), Gaps = 1/416 (0%)

Query: 85  KEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRST 143
           +EPSNKRV+PL+RVTSLANLI PV+   ++RF QT+Q S + R + R    A +  SR+ 
Sbjct: 38  REPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNA 97

Query: 144 VPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDP 203
            P+  KRR S LWSE  D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDP
Sbjct: 98  APSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDP 157

Query: 204 MLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAY 263
           MLKLSIM+E+EL  IFG LDS IPLHE+LL+++ +  KPDG+ E +G ILV WLP L++Y
Sbjct: 158 MLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSY 217

Query: 264 RGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLK 323
             YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+
Sbjct: 218 DSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLR 277

Query: 324 EILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEA 383
           EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D  I++
Sbjct: 278 EILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDS 337

Query: 384 SKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQD 443
           S+VL CHGEL++  G KL++FLFQ++LV+TR VT NE+  YQ+YRQPIPV++L+LEDLQD
Sbjct: 338 SRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQD 397

Query: 444 GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 499
           G+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 398 GEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 453


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  122 bits (305), Expect = 1e-27
 Identities = 100/370 (27%), Positives = 176/370 (47%), Gaps = 55/370 (14%)

Query: 161  DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 220
            D+ + + LT  E +RQ  I+E+   E++ + DL+L  + +  P+++  +++E+E+  IF 
Sbjct: 1224 DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFV 1283

Query: 221  DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 277
            +    I  +  LL  +    K  G    V+ IG IL + LP +  Y  +CS QL   AL+
Sbjct: 1284 NWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALI 1343

Query: 278  DQKKQD-PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 336
             QK  + P  ++F++R    P  + + L SF+  P  R+ +YPL++K IL++TP+ HPD 
Sbjct: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403

Query: 337  QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQR----DPRIEASKVLLCHGE 392
              L+ A+   + + S +N    E E     D+LE++    +      ++  + V  C G 
Sbjct: 1404 SHLKHALEKAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLSEQLVFNSVTNCLGP 1460

Query: 393  ---------LRSKSGHKLYIFLFQDILVLT------------RPVTRNERHSYQVYRQPI 431
                      ++KS  +LY FLF D L+LT            +  +      Y++Y+ PI
Sbjct: 1461 RKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520

Query: 432  PVQELVLEDLQD--GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHK 489
             + E++++   D  GD                 + IF I   D    + +TL+A  +  +
Sbjct: 1521 FLNEVLVKLPTDPSGD-----------------EPIFHISHID----RVYTLRAESINER 1559

Query: 490  QQWFNCIRAA 499
              W   I+AA
Sbjct: 1560 TAWVQKIKAA 1569


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  105 bits (261), Expect = 2e-22
 Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)

Query: 161  DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 220
            D+   +++   E +RQ  I+E+ + E+  + DL+L  + +   M +   ++E E+  IF 
Sbjct: 1169 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1228

Query: 221  DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 277
            +    I  +  LL  +    K  G    V+ IG IL + L  + AY  +CS QL   ALL
Sbjct: 1229 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1288

Query: 278  DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 336
             QK  +D   ++FL++    P  + + L SFL  P  R+ +YPLL++ IL++TP+ H D 
Sbjct: 1289 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1348

Query: 337  QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 386
              L+ A+   + + S +N    E E     D+LE++    +   +    +          
Sbjct: 1349 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1405

Query: 387  --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 430
              LL  G+L ++KS  +L+ FLF D L+LT  V             +      +++Y+ P
Sbjct: 1406 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1465

Query: 431  IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 490
            I + E++++   D             S+ E         FH     + +TL+ +++  + 
Sbjct: 1466 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1506

Query: 491  QWFNCIRAA 499
             W   I+AA
Sbjct: 1507 AWVQKIKAA 1515


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  105 bits (261), Expect = 2e-22
 Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)

Query: 161  DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 220
            D+   +++   E +RQ  I+E+ + E+  + DL+L  + +   M +   ++E E+  IF 
Sbjct: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255

Query: 221  DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 277
            +    I  +  LL  +    K  G    V+ IG IL + L  + AY  +CS QL   ALL
Sbjct: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1315

Query: 278  DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 336
             QK  +D   ++FL++    P  + + L SFL  P  R+ +YPLL++ IL++TP+ H D 
Sbjct: 1316 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1375

Query: 337  QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 386
              L+ A+   + + S +N    E E     D+LE++    +   +    +          
Sbjct: 1376 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1432

Query: 387  --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 430
              LL  G+L ++KS  +L+ FLF D L+LT  V             +      +++Y+ P
Sbjct: 1433 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1492

Query: 431  IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 490
            I + E++++   D             S+ E         FH     + +TL+ +++  + 
Sbjct: 1493 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1533

Query: 491  QWFNCIRAA 499
             W   I+AA
Sbjct: 1534 AWVQKIKAA 1542


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 84/344 (24%), Positives = 159/344 (46%), Gaps = 45/344 (13%)

Query: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSI------MSEEELTHIFGDLDSYIPLHEDLLT 234
           E+ + E+D +  L+    A+   M + +       ++EE +  +F +++  + +H++ L 
Sbjct: 30  ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89

Query: 235 RIGEATKPDGTVEQ-IGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRC 293
            + E   P+   +Q +G   + +  +   Y  YCSN   A+ LL +  +   ++ FL  C
Sbjct: 90  VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149

Query: 294 LESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLS 351
           +     +  D  L  +L  P  R+ KYPL+LKE+LK TP++H D   + +A+  ++ V S
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209

Query: 352 DINLKKGESECQYYIDKLEYLDEKQRDPRIE----------ASKVLLCHGELRSKSGH-- 399
           +IN      E +  ++KLE L+E Q    IE           +++L+C   L+  SG+  
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQ--SHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ 261

Query: 400 KLYIFLFQDILVLTRPVTRNERHS-------YQVYRQPIPVQELVLEDLQDGDVRMGGSF 452
           +   FLF ++LV  +   R  ++S         ++R  I  + + +E++ DG        
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADF---- 317

Query: 453 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCI 496
               S+     N ++I  H+ +  +     A     K +WF  I
Sbjct: 318 ---HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAI 356


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 84/344 (24%), Positives = 159/344 (46%), Gaps = 45/344 (13%)

Query: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSI------MSEEELTHIFGDLDSYIPLHEDLLT 234
           E+ + E+D +  L+    A+   M + +       ++EE +  +F +++  + +H++ L 
Sbjct: 30  ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89

Query: 235 RIGEATKPDGTVEQ-IGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRC 293
            + E   P+   +Q +G   + +  +   Y  YCSN   A+ LL +  +   ++ FL  C
Sbjct: 90  VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149

Query: 294 LESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLS 351
           +     +  D  L  +L  P  R+ KYPL+LKE+LK TP++H D   + +A+  ++ V S
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209

Query: 352 DINLKKGESECQYYIDKLEYLDEKQRDPRIE----------ASKVLLCHGELRSKSGH-- 399
           +IN      E +  ++KLE L+E Q    IE           +++L+C   L+  SG+  
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQ--SHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQ 261

Query: 400 KLYIFLFQDILVLTRPVTRNERHS-------YQVYRQPIPVQELVLEDLQDGDVRMGGSF 452
           +   FLF ++LV  +   R  ++S         ++R  I  + + +E++ DG        
Sbjct: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADF---- 317

Query: 453 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCI 496
               S+     N ++I  H+ +  +     A     K +WF  I
Sbjct: 318 ---HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAI 356


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 75/306 (24%), Positives = 141/306 (46%), Gaps = 28/306 (9%)

Query: 210 MSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE-QIGHILVSWLPRLNAYRGYCS 268
           ++EE +  +F +++  + +H+D L  +     P+   + ++G++ + +  +   Y  YCS
Sbjct: 91  LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150

Query: 269 NQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLD--LWSFLDIPRSRLVKYPLLLKEIL 326
           N   A  LL +  + P V+ FL  C+     +  D  L  +L  P  R+ KYPLLLKE+ 
Sbjct: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210

Query: 327 KHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLE-YLDEKQRDPRIEASK 385
           K TP +HPD   ++ A+  ++ V S+IN  K + E    +++L+ +++  +     +   
Sbjct: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270

Query: 386 VLLCHGELRSKSGHKLY---IFLFQDILVLTR------------PVTRNERHSYQVYRQP 430
            LL  G L   S   +     FLF ++LV  +              T++   S  ++R  
Sbjct: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330

Query: 431 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 490
           I  + + +E+++DG            SN     N ++I  H+ +  +     A     KQ
Sbjct: 331 INTEVMEVENVEDGTA-------DYHSNGYTVTNGWKI--HNTAKNKWFVCMAKTAEEKQ 381

Query: 491 QWFNCI 496
           +W + I
Sbjct: 382 KWLDAI 387


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 78/281 (27%), Positives = 129/281 (45%), Gaps = 24/281 (8%)

Query: 156  WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
            W +++   +   L   EI+RQE I E+   E+  +  LK+  + ++  + +  I+S  EL
Sbjct: 769  WQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSEL 828

Query: 216  THIFGDLDSYIPLHEDLLTRIGEATKPDGT--VEQIGHILVSWLPR------LNAYRGYC 267
              IF +L+  + LH  L  ++    K + T  ++QIG  L++W          +A   +C
Sbjct: 829  RKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFC 888

Query: 268  SNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 326
            SNQ  A + +  ++K+D R Q F+Q    +P  R+L L   +     RL KYPLLL  I 
Sbjct: 889  SNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIA 948

Query: 327  KHT--PKEHPDVQLLED-AILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIE 382
            K+T  P E   V+   D    I+  V   +   + +   + Y  +L+    K  + P +E
Sbjct: 949  KYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVE 1008

Query: 383  -------ASKVLLCHGELRSKSGH----KLYIFLFQDILVL 412
                     + ++  G L  K        LY  L +DILVL
Sbjct: 1009 ELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVL 1049


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
           W E++      SL   +++RQE I E+   E   +  L++    +  PM +      EEL
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472

Query: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 266
            +IF  LD  I +H   L R+ +  +  G  +E+IG +L+        SW  ++++   +
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 530

Query: 267 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 325
           CS Q  A + L  ++++DPR   F+Q     P  R+L L   +     RL KYPLLL+ I
Sbjct: 531 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 590

Query: 326 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 378
            ++T  P E   V+L  +     + +L  +N    + E     + Y  +L+    +Q  D
Sbjct: 591 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 647

Query: 379 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 426
           P       ++ +K  L H       +      ++++ L  D +L+L R   R    S+  
Sbjct: 648 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 707

Query: 427 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 486
              P P  + +L  +    +R+  +     +   KA   F + F     AQ + L A  V
Sbjct: 708 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 760

Query: 487 FHKQQW 492
             ++ W
Sbjct: 761 SERKNW 766


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
           W E++      SL   +++RQE I E+   E   +  L++    +  PM +      EEL
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424

Query: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 266
            +IF  LD  I +H   L R+ +  +  G  +E+IG +L+        SW  ++++   +
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482

Query: 267 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 325
           CS Q  A + L  ++++DPR   F+Q     P  R+L L   +     RL KYPLLL+ I
Sbjct: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542

Query: 326 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 378
            ++T  P E   V+L  +     + +L  +N    + E     + Y  +L+    +Q  D
Sbjct: 543 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 599

Query: 379 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 426
           P       ++ +K  L H       +      ++++ L  D +L+L R   R    S+  
Sbjct: 600 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 659

Query: 427 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 486
              P P  + +L  +    +R+  +     +   KA   F + F     AQ + L A  V
Sbjct: 660 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 712

Query: 487 FHKQQW 492
             ++ W
Sbjct: 713 SERKNW 718


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 91/366 (24%), Positives = 159/366 (43%), Gaps = 41/366 (11%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
           W E++      SL   +++RQE I E+   E   +  L++    +  PM +      EEL
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457

Query: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDG-TVEQIGHILV--------SWLPRLNAYRGY 266
            +IF  LD  I +H   L R+ +  +  G  +E+IG +L+        SW  ++++   +
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 515

Query: 267 CSNQ-LAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEI 325
           CS Q  A + L  ++++DPR   F+Q     P  R+L L   +     RL KYPLLL+ I
Sbjct: 516 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 575

Query: 326 LKHT--PKEHPDVQLLEDAILIIQGVLSDINLKKGESE----CQYYIDKLEYLDEKQ-RD 378
            ++T  P E   V+L  +     + +L  +N    + E     + Y  +L+    +Q  D
Sbjct: 576 GQNTEEPTEREKVELAAEC---CREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD 632

Query: 379 P------RIEASKVLLCH-----GELRSKSGHKLYIFLFQD-ILVLTRPVTRNERHSYQV 426
           P       ++ +K  L H       +      ++++ L  D +L+L R   R    S+  
Sbjct: 633 PMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSR 692

Query: 427 YRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDV 486
              P P  + +L  +    +R+  +     +   KA   F + F     AQ + L A  V
Sbjct: 693 TLTPTPDGKTMLRPV----LRLTSAMTREVATDHKA---FYVLFTWDQEAQIYELVAQTV 745

Query: 487 FHKQQW 492
             ++ W
Sbjct: 746 SERKNW 751


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 98/454 (21%), Positives = 190/454 (41%), Gaps = 39/454 (8%)

Query: 13  PRRRSRRASGLSTEGATGPSADTS-----GSELDGRCSLRRGSSFTF----LTPGPNWDF 63
           P +R  +   +  EG  GP           +++D   SLRRG   T     +  G ++D 
Sbjct: 271 PHKRLLKVRSM-VEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDS 329

Query: 64  TLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSF 123
               K++ +    V    ++ KE  +   R   ++           N AV       ++ 
Sbjct: 330 PTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEEN-AVLYQNYKEKAL 388

Query: 124 TLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMK---ESLTTREIRRQEAIY 180
            +  D  S    QK   +  +     R +   WS++  +  K   ++++  E +RQEAI+
Sbjct: 389 DIDSDEESEPKEQKSDEKIVIHHKPLRST---WSQLSAVKRKGLSQTVSQEERKRQEAIF 445

Query: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT 240
           E+   E   +  L++  + + +       M++ E  H+F ++       +     +    
Sbjct: 446 EVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARH 505

Query: 241 KPDGTVEQIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLESPF 298
           + +  ++ I  I+        + Y  YC+N++  +  L +    +P  ++ L R      
Sbjct: 506 QNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHED 565

Query: 299 SRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN---L 355
            R L + SFL +P  R+ + PLL+  I + TPK+ P  ++ + A+  +  ++   N    
Sbjct: 566 CRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGAR 625

Query: 356 KKGESECQYYID-KLEYLDEKQRDPRIEASKVLLCHGEL-----------RSKSGHKLYI 403
           K   +E  Y I+ +LE+  + +  P + +S+ L+  GEL           R  S  ++Y 
Sbjct: 626 KMERTEMMYTINSQLEF--KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYF 683

Query: 404 FLFQDILVLTRPVTRNERHSYQVYRQPIPVQELV 437
           FLF D+L++T+   +    SY V    +  Q LV
Sbjct: 684 FLFNDVLIITK---KKSEESYNVNDYSLRDQLLV 714


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)

Query: 148  AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207
            +K+  +  WS ++D    +      ++RQE IYE+ + E   +  LK+    Y   M+  
Sbjct: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031

Query: 208  SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259
             +  ++ +  +F  LD  I +H     RI E  K         +  +++IG +LV+    
Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091

Query: 260  LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312
             NA      Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151

Query: 313  SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372
             R+ KYP+L + IL+ T     + + L  ++ +++ V+  ++ K    E +  ++++   
Sbjct: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2211

Query: 373  DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418
             + +   R+++           K L+  G   L++ +G   ++   L  DILV  +   +
Sbjct: 2212 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2269

Query: 419  NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475
            ++++ +    Q    I +++L++ ++               ++ EK   +  +   DP  
Sbjct: 2270 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2314

Query: 476  AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534
             + H   A+    +  W   I+  I    +  +  E +G+P E  EE +     AR+L  
Sbjct: 2315 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2367

Query: 535  QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589
            Q        +  +E  E  +R      MAE S  L      TH  +   R   ++AL GG
Sbjct: 2368 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2422


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)

Query: 148 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207
           +K+  +  WS ++D    +      ++RQE IYE+ + E   +  LK+    Y   M+  
Sbjct: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272

Query: 208 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259
            +  ++ +  +F  LD  I +H     RI E  K         +  +++IG +LV+    
Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332

Query: 260 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312
            NA      Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392

Query: 313 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372
            R+ KYP+L + IL+ T     + + L  ++ +++ V+  ++ K    E +  ++++   
Sbjct: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 452

Query: 373 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418
            + +   R+++           K L+  G   L++ +G   ++   L  DILV  +   +
Sbjct: 453 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 510

Query: 419 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475
           ++++ +    Q    I +++L++ ++               ++ EK   +  +   DP  
Sbjct: 511 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 555

Query: 476 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534
            + H   A+    +  W   I+  I    +  +  E +G+P E  EE +     AR+L  
Sbjct: 556 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 608

Query: 535 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589
           Q        +  +E  E  +R      MAE S  L      TH  +   R   ++AL GG
Sbjct: 609 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 663


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)

Query: 148  AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207
            +K+  +  WS ++D    +      ++RQE IYE+ + E   +  LK+    Y   M+  
Sbjct: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027

Query: 208  SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259
             +  ++ +  +F  LD  I +H     RI E  K         +  +++IG +LV+    
Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087

Query: 260  LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312
             NA      Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147

Query: 313  SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372
             R+ KYP+L + IL+ T     + + L  ++ +++ V+  ++ K    E +  ++++   
Sbjct: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2207

Query: 373  DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418
             + +   R+++           K L+  G   L++ +G   ++   L  DILV  +   +
Sbjct: 2208 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2265

Query: 419  NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475
            ++++ +    Q    I +++L++ ++               ++ EK   +  +   DP  
Sbjct: 2266 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2310

Query: 476  AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534
             + H   A+    +  W   I+  I    +  +  E +G+P E  EE +     AR+L  
Sbjct: 2311 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2363

Query: 535  QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589
            Q        +  +E  E  +R      MAE S  L      TH  +   R   ++AL GG
Sbjct: 2364 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2418


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 84/344 (24%), Positives = 144/344 (41%), Gaps = 33/344 (9%)

Query: 168 LTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIM-SEEELTHIFGDLDSYI 226
           L  R+  R   I E+   E+  I+ LK   + Y     K   M S+E+L  IFG+++   
Sbjct: 97  LQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIY 156

Query: 227 PLHEDLLTRIGEA-TKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPR 285
                 +  + +     D  + +IG   +        Y  YC+N L A   L +  +D R
Sbjct: 157 RFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR 216

Query: 286 VQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILI 345
            Q F + C        + +  FL  P  ++ KYPL L E+LK+T ++H D + +  A+ +
Sbjct: 217 YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAV 276

Query: 346 IQGVLSDINLKKGESECQYYIDKL-----EYLDEKQRDPRIEASKVLLCHGELR------ 394
           ++ V   IN +K   E    IDK+       LD +  D  ++ S  L+  GE+       
Sbjct: 277 MRNVTQQINERKRRLE---NIDKIAQWQASVLDWEGED-ILDRSSELIYTGEMAWIYQPY 332

Query: 395 SKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG-DVRMGGSFR 453
            ++  +++ FLF   +VL +      R     Y+  I + +  + D++DG D     S +
Sbjct: 333 GRNQQRVF-FLFDHQMVLCKKDL--IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMK 389

Query: 454 GAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIR 497
            AF            + H+    + H   A  +  K +W    R
Sbjct: 390 NAF------------KLHNKETEEIHLFFAKKLEEKIRWLRAFR 421


>gi|222080070 pleckstrin homology domain-containing family G member
           6 isoform b [Homo sapiens]
          Length = 758

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212
           W E+  +   + ++     +QEA++E+   E   +  LK+        +L L    ++ E
Sbjct: 113 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 170

Query: 213 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 265
                +FG++ S I  H    +++L    E T+  G  ++ IG     +++  R + Y  
Sbjct: 171 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 230

Query: 266 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324
           YC       A   +Q++ +P    F+Q C +   S +  L   L  P  R+ KYPLLL  
Sbjct: 231 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 290

Query: 325 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 373
           +LK +P+     + L   I  ++  L  IN  +++GE +         I   E L    D
Sbjct: 291 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 349

Query: 374 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 414
           E +++ R                E ++ LL  G +R K G +    +Y+FLF D+L++T+
Sbjct: 350 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409

Query: 415 PVTRNERHSYQVYRQPIPVQELVLEDLQD 443
           P  + ++   +V R P+ +++LV + L+D
Sbjct: 410 PQRKADK--AKVIRPPLMLEKLVCQPLRD 436


>gi|222080068 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212
           W E+  +   + ++     +QEA++E+   E   +  LK+        +L L    ++ E
Sbjct: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202

Query: 213 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 265
                +FG++ S I  H    +++L    E T+  G  ++ IG     +++  R + Y  
Sbjct: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262

Query: 266 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324
           YC       A   +Q++ +P    F+Q C +   S +  L   L  P  R+ KYPLLL  
Sbjct: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322

Query: 325 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 373
           +LK +P+     + L   I  ++  L  IN  +++GE +         I   E L    D
Sbjct: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381

Query: 374 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 414
           E +++ R                E ++ LL  G +R K G +    +Y+FLF D+L++T+
Sbjct: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441

Query: 415 PVTRNERHSYQVYRQPIPVQELVLEDLQD 443
           P  + ++   +V R P+ +++LV + L+D
Sbjct: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468


>gi|222080066 pleckstrin homology domain-containing family G member
           6 isoform a [Homo sapiens]
          Length = 790

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 46/329 (13%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLS---IMSE 212
           W E+  +   + ++     +QEA++E+   E   +  LK+        +L L    ++ E
Sbjct: 145 WREL--VPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLME 202

Query: 213 EELTHIFGDLDSYIPLH----EDLLTRIGEATKPDGT-VEQIG--HILVSWLPRLNAYRG 265
                +FG++ S I  H    +++L    E T+  G  ++ IG     +++  R + Y  
Sbjct: 203 VSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQ 262

Query: 266 YCSNQLAAKALL-DQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 324
           YC       A   +Q++ +P    F+Q C +   S +  L   L  P  R+ KYPLLL  
Sbjct: 263 YCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHA 322

Query: 325 ILKHTPKEHPDVQLLEDAILIIQGVLSDIN--LKKGESE-----CQYYIDKLEYL----D 373
           +LK +P+     + L   I  ++  L  IN  +++GE +         I   E L    D
Sbjct: 323 VLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSD 381

Query: 374 EKQRDPR---------------IEASKVLLCHGELRSKSGHK----LYIFLFQDILVLTR 414
           E +++ R                E ++ LL  G +R K G +    +Y+FLF D+L++T+
Sbjct: 382 EVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441

Query: 415 PVTRNERHSYQVYRQPIPVQELVLEDLQD 443
           P  + ++   +V R P+ +++LV + L+D
Sbjct: 442 PQRKADK--AKVIRPPLMLEKLVCQPLRD 468


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 54/190 (28%), Positives = 97/190 (51%), Gaps = 17/190 (8%)

Query: 174 RRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLL 233
           +R + I E+ + E+D I DL++  +    PM +  + + +    +FG++   I + + LL
Sbjct: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-FEGLFGNMQMVIKVSKQLL 842

Query: 234 TRIGEATKPDGTVEQIGHILVSWLPRLNA-YRGYCSNQLAAKALLDQKKQDPRVQDFLQR 292
             +  +       + +G + +     L   Y+ YC N   A ALL+  ++D ++Q  LQ 
Sbjct: 843 AALEIS-------DAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895

Query: 293 CL--------ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAIL 344
            L        E   +  ++L SFL  P  R+++YPLLL E+L  TP+ HPD   L +A+L
Sbjct: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955

Query: 345 IIQGVLSDIN 354
            ++ +  +IN
Sbjct: 956 AVKEINVNIN 965


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 73/298 (24%), Positives = 140/298 (46%), Gaps = 37/298 (12%)

Query: 147 PAKRRSSALWSEMLDITMKESLT---TREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDP 203
           P +     ++ +++ + +++ +    T + +R   + E+   E      L+   K Y  P
Sbjct: 163 PCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP 222

Query: 204 MLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAY 263
            L+L ++S  ++  +F +L+  I +H   L  I  +    G+   +  + + +  RL  Y
Sbjct: 223 -LRL-VLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGST--LAKVFLDFKERLLIY 278

Query: 264 RGYCSNQLAAKALLDQ---KKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 320
             YCS+   A+  L+Q    ++D R +  ++ C       K  L   L +P  R++KY L
Sbjct: 279 GEYCSHMEHAQNTLNQLLASREDFRQK--VEECTLKVQDGKFKLQDLLVVPMQRVLKYHL 336

Query: 321 LLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGE-------SECQYYIDKLEYLD 373
           LLKE+L H+  E P+ Q L++A+  +Q +   IN  K +       SE Q  I+ L+   
Sbjct: 337 LLKELLSHS-AERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKL 395

Query: 374 EKQRDPRIEASKVLLCHGELRSKS-----GHKLYIFLFQDILVLTRPVTRNERHSYQV 426
           E+   P+I+        GEL+ +S         Y+FLF  +++    V + + +SY++
Sbjct: 396 EEFGRPKID--------GELKVRSIVNHTKQDRYLFLFDKVVI----VCKRKGYSYEL 441


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 73/278 (26%), Positives = 131/278 (47%), Gaps = 34/278 (12%)

Query: 164 MKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLD 223
           M++   T + +R   + E+   E      L+   K Y  P L+L ++S  ++  +F +L+
Sbjct: 188 MQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP-LRL-VLSPADMAAVFINLE 245

Query: 224 SYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQ---K 280
             I +H   L  I  +    G+   +  + + +  RL  Y  YCS+   A+  L+Q    
Sbjct: 246 DLIKVHHSFLRAIDVSVMVGGST--LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 303

Query: 281 KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLE 340
           ++D R +  ++ C       K  L   L +P  R++KY LLLKE+L H+  E P+ Q L+
Sbjct: 304 REDFRQK--VEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLK 360

Query: 341 DAILIIQGVLSDINLKKGE-------SECQYYIDKLEYLDEKQRDPRIEASKVLLCHGEL 393
           +A+  +Q +   IN  K +       SE Q  I+ L+   E+   P+I+        GEL
Sbjct: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID--------GEL 412

Query: 394 RSKS-----GHKLYIFLFQDILVLTRPVTRNERHSYQV 426
           + +S         Y+FLF  +++    V + + +SY++
Sbjct: 413 KVRSIVNHTKQDRYLFLFDKVVI----VCKRKGYSYEL 446


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 75/338 (22%), Positives = 144/338 (42%), Gaps = 24/338 (7%)

Query: 131 SPASAQKFSSRSTVPTPAKRRSSALWS---EMLDITMKESLTTREIRRQEAIYEMSRGEQ 187
           SP   QK  +  T+   + R +   WS   E++++ + + L+T E +RQEA++E+   E 
Sbjct: 240 SPEGTQKVDA--TIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEF 297

Query: 188 DLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVE 247
                L +  + +       + +++ E  H+F ++   +   +     + +  K    VE
Sbjct: 298 SYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVE 357

Query: 248 QIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLW 305
            I  IL     +  + Y  YCSN++  +  L +    +   ++ L+     P    L + 
Sbjct: 358 DISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPML 417

Query: 306 SFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINL---KKGESEC 362
           SFL +P  R+ + PLL+  +   T       +    A+  I  ++   N    +    E 
Sbjct: 418 SFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQ 477

Query: 363 QYYIDKLEYLDEKQRDPRIEASKVLLCHGEL----------RSKSGHKLYIFLFQDILVL 412
            Y +       + +  P I AS+ LL  GEL          +  S    Y+FLF D+LV+
Sbjct: 478 MYTLHTQLDFSKVKSLPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVV 537

Query: 413 TRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGG 450
           T+  +  E +  Q Y Q   +  + +E ++  ++ + G
Sbjct: 538 TKKKS-EESYMVQDYAQ---MNHIQVEKIEPSELPLPG 571


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
           2 [Homo sapiens]
          Length = 1562

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 11/183 (6%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
           W   +   +   LT REI RQE I E+   E   +  L++    ++  M K ++M  EEL
Sbjct: 756 WQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREEL 815

Query: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVS--------WLPRLNAYRGYC 267
             +F +L   I +H      + +  +    +++I  ++++         L ++ A   +C
Sbjct: 816 ARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ--FC 873

Query: 268 SNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 326
           S Q  A  L+  K +++ R Q F+Q     P  R+L L   +     RL KYPLLL+ I+
Sbjct: 874 SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESII 933

Query: 327 KHT 329
           KHT
Sbjct: 934 KHT 936


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
           1 [Homo sapiens]
          Length = 1522

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 11/183 (6%)

Query: 156 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEEL 215
           W   +   +   LT REI RQE I E+   E   +  L++    ++  M K ++M  EEL
Sbjct: 716 WQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREEL 775

Query: 216 THIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVS--------WLPRLNAYRGYC 267
             +F +L   I +H      + +  +    +++I  ++++         L ++ A   +C
Sbjct: 776 ARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ--FC 833

Query: 268 SNQLAAKALLDQK-KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEIL 326
           S Q  A  L+  K +++ R Q F+Q     P  R+L L   +     RL KYPLLL+ I+
Sbjct: 834 SYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESII 893

Query: 327 KHT 329
           KHT
Sbjct: 894 KHT 896


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 82/340 (24%), Positives = 147/340 (43%), Gaps = 31/340 (9%)

Query: 166 ESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIM-SEEELTHIFGDLDS 224
           E+ ++++  R   I E+   E+D I+ L+   + Y     K + M SEE+L  IFG+++ 
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIED 335

Query: 225 YIPLHEDLLTRIGEATKPDGT-VEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQD 283
                +  +  + +    +   + ++G   +        Y  YC+N   A   L +  + 
Sbjct: 336 IYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKL 395

Query: 284 PRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAI 343
            +   F + C        + L  FL  P  ++ KYPL L E+LK+T  +H D + +E A+
Sbjct: 396 SKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAAL 455

Query: 344 LIIQGVLSDINLKKGESECQYYIDKL----EYLDEKQRDPRIEASKVLLCHGEL------ 393
             ++ V   IN +K   E    IDK+      +++ + +  +  S  L+  GEL      
Sbjct: 456 HAMKNVAQLINERKRRLE---NIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512

Query: 394 RSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG-DVRMGGSF 452
           ++KS  +++ FLF   L+  +      R     Y+  + +  L + DL+DG D  +  S 
Sbjct: 513 QAKSQQRMF-FLFDHQLIYCKKDLL--RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSI 569

Query: 453 RGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQW 492
           + AF            R H  +   SH L       KQ+W
Sbjct: 570 KNAF------------RLHRGATGDSHLLCTRKPEQKQRW 597


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,473,840
Number of Sequences: 37866
Number of extensions: 1083695
Number of successful extensions: 4010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 3788
Number of HSP's gapped (non-prelim): 180
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.