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Search of human proteins with 213021186
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
(577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 1182 0.0
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 1182 0.0
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 1077 0.0
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 1077 0.0
gi|19913367 transducin beta-like 1Y [Homo sapiens] 985 0.0
gi|19913365 transducin beta-like 1Y [Homo sapiens] 985 0.0
gi|15150805 transducin beta-like 1Y [Homo sapiens] 985 0.0
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 943 0.0
gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo ... 187 2e-47
gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo ... 187 2e-47
gi|239754401 PREDICTED: similar to transducin (beta)-like 1 X-li... 151 2e-36
gi|32189425 WD repeat domain 69 [Homo sapiens] 138 1e-32
gi|26665869 WD repeat domain 51B [Homo sapiens] 129 7e-30
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 124 3e-28
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 124 3e-28
gi|16554629 WD repeat domain 5 [Homo sapiens] 123 4e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 123 4e-28
gi|4757988 WD repeat domain 39 [Homo sapiens] 123 5e-28
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 120 4e-27
gi|23199987 WD repeat domain 5B [Homo sapiens] 119 8e-27
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 115 8e-26
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 115 1e-25
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 115 1e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 113 4e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 113 4e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 113 4e-25
gi|21071067 TBP-associated factor 5 [Homo sapiens] 112 7e-25
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 105 1e-22
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 105 1e-22
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 103 6e-22
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 1182 bits (3057), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
Sbjct: 1 MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
Query: 61 FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
Sbjct: 61 FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
Query: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
Sbjct: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
Query: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
Sbjct: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
Query: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
Query: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 1182 bits (3057), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
Sbjct: 1 MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN 60
Query: 61 FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
Sbjct: 61 FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED 120
Query: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
Sbjct: 121 GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA 180
Query: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
Sbjct: 181 GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW 240
Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
Query: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
Sbjct: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
Query: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 541 HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 1077 bits (2785), Expect = 0.0
Identities = 526/526 (100%), Positives = 526/526 (100%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA
Sbjct: 61 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 1077 bits (2785), Expect = 0.0
Identities = 526/526 (100%), Positives = 526/526 (100%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA
Sbjct: 61 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 180
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 300
Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH
Sbjct: 301 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 360
Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN
Sbjct: 361 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 420
Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 480
Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Sbjct: 481 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 985 bits (2546), Expect = 0.0
Identities = 477/524 (91%), Positives = 499/524 (95%), Gaps = 2/524 (0%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPP+ALISILQKGLQYV
Sbjct: 1 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAEISIN+DGTVFD RPIESLSLI AV+PDVVQ RQQAF EKL QQQASAAA A+A A
Sbjct: 61 EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGH 231
A AT T A +S QNP KNREATVNGEEN AH +NNH+KPMEIDG+VEIP +KATVLRGH
Sbjct: 121 A--ATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGH 178
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 292 TSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDK 351
TSLDWN++GTLLA GSYDGFARIWTE+GNLASTLGQHKGPIFALKWN+KGNY+LSAGVDK
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDK 298
Query: 352 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 411
TTIIWDAHTGEAKQQFPFHSAPALDVDWQNN TFASCSTDMCIHVCRLGCD PVKTFQGH
Sbjct: 299 TTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 412 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSN 471
TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ+ C+HDLQAH+KEIYTIKWSPTGPATSN
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHI 531
PNS+IMLASASFDSTVRLWD+E+GVCTHTL KHQEPVYSVAFSPDGKYLASGSFDK VHI
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 532 WNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
WNTQSG+LVHSY+GTGGIFEVCWNARGDKVGASASDGSVCVLDL
Sbjct: 479 WNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 943 bits (2437), Expect = 0.0
Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)
Query: 52 MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111
MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 1 MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
Query: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171
EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA
Sbjct: 61 EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118
Query: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 230
S Q +KN E T NGEEN AH++ NNH ME+DG+VEIP +KA VLRG
Sbjct: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167
Query: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 290
HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS GSTQLVLRHCIREGG DVPSNKD
Sbjct: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
Query: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 350
VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287
Query: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410
KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347
Query: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470
HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407
Query: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530
NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
Query: 531 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577
IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
>gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo
sapiens]
Length = 155
Score = 187 bits (475), Expect = 2e-47
Identities = 102/154 (66%), Positives = 116/154 (75%), Gaps = 11/154 (7%)
Query: 73 SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 9 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67
Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNRE 192
SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A +A + KN E
Sbjct: 68 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK---------KKKKKKKNAE 118
Query: 193 ATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKA 225
T NGEEN AH + NNH ME+DG++EIP +KA
Sbjct: 119 NTANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 152
>gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo
sapiens]
Length = 177
Score = 187 bits (475), Expect = 2e-47
Identities = 102/154 (66%), Positives = 116/154 (75%), Gaps = 11/154 (7%)
Query: 73 SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 31 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 89
Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNRE 192
SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A +A + KN E
Sbjct: 90 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSAKKK---------KKKKKKKNAE 140
Query: 193 ATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKA 225
T NGEEN AH + NNH ME+DG++EIP +KA
Sbjct: 141 NTANGEENGAHIIANNHTDTMEVDGDIEIPPNKA 174
>gi|239754401 PREDICTED: similar to transducin (beta)-like 1
X-linked receptor 1 [Homo sapiens]
Length = 132
Score = 151 bits (381), Expect = 2e-36
Identities = 79/98 (80%), Positives = 87/98 (88%), Gaps = 1/98 (1%)
Query: 73 SHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESL 132
SHSAFTFGIES ISQSNING LVPPAALISI+QKGLQYVEAE+SINEDGT FDGRP+ SL
Sbjct: 9 SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67
Query: 133 SLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATA 170
SLIDA+MPDVVQTRQQA+ +KL QQQA+AA A +A
Sbjct: 68 SLIDALMPDVVQTRQQAYSDKLKQQQAAAATANQQGSA 105
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 138 bits (348), Expect = 1e-32
Identities = 94/309 (30%), Positives = 144/309 (46%), Gaps = 28/309 (9%)
Query: 228 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286
L GH + V+ A+N P D +A+GS D T ++W++ H R GH
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK--------CYHTFR--GHTA- 178
Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYIL 345
++ L +N TL+ATGS D A++W ++G TL H I +L +N G+ I+
Sbjct: 179 ---EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235
Query: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQNNTTFASCSTDMCIHVCRLGCDR 403
+ D T ++WDA TG H A + +W + S D + +
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294
Query: 404 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS 463
V T GH +E+ +D +G L+A+ S D T +I+S CI L+ H EI I ++
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
Query: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 523
P G N +L +S D T R+WD + G C L H + ++S AF+ G + +G
Sbjct: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Query: 524 SFDKCVHIW 532
S D IW
Sbjct: 406 SKDNTCRIW 414
Score = 100 bits (250), Expect = 3e-21
Identities = 62/252 (24%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
L L H P+ + N+ G+ ++ D+T +WD +GE H + +
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 381 N--NTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKI 438
N A+ S D + + + TF+GHT E+ + ++P L+A+ S D T K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 439 WSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT 498
W ++ ++ L+ H+ EI ++ ++ +G + + SFD TV +WD + G
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254
Query: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
+ L H + S +F+ D + +GS DK +W+ +G V + G I + C++
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314
Query: 558 GDKVGASASDGS 569
G + +++DG+
Sbjct: 315 GKLIATASADGT 326
Score = 88.6 bits (218), Expect = 1e-17
Identities = 49/170 (28%), Positives = 83/170 (48%), Gaps = 9/170 (5%)
Query: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
K + H + + + SG + S D T K+W ++ L+ H +Y I
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI----- 140
Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
A +NP + +A+ SFD T +LW +E G C HT H + ++F+P +A+GS
Sbjct: 141 --AFNNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
Query: 526 DKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
D +W+ Q+G V++ RG + I + +N GD++ + D +V V D
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/217 (25%), Positives = 95/217 (43%), Gaps = 56/217 (25%)
Query: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGH 283
K +L GH +E+ ++N L+ +GS D T ++W + +NG + GH
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW---DATNGKCVATLT-------GH 302
Query: 284 DVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGN 342
D ++ ++ G L+AT S DG ARI++ + L H+G I + +N +GN
Sbjct: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCD 402
++L+ DKT IWDA TG+ C+ V
Sbjct: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382
Query: 403 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
+GHT+E+ + ++ G ++ + S D T +IW
Sbjct: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 129 bits (324), Expect = 7e-30
Identities = 82/283 (28%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL-ASTLGQHKGPIFALKWNRKGNYILSAGV 349
+TSLD + NG LAT S+D F +W + A HK + +++++ GN + SA
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTF 408
D+T +W +F H+AP VD+ + F A+ S D I V + R + +
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
HT+ V K+ P G L+ SCS+D T+KIW + C+++ + ++P+G
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTC 200
Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
+ASA D TV++WD+ H V ++F P G YL + S D
Sbjct: 201 ---------IASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 529 VHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSV 570
+ I + G L+++ +G TG +F V ++ G+ + +D V
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Score = 99.0 bits (245), Expect = 1e-20
Identities = 74/268 (27%), Positives = 124/268 (46%), Gaps = 18/268 (6%)
Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
P ++A GH+ V ++P +LLAS S D T R+W ++ +
Sbjct: 49 PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--------- 99
Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNR 339
H P V S+D++ +G LAT S D ++W+ +L +H + K++
Sbjct: 100 -AHTAP----VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154
Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
G I+S DKT IWD + F A VD+ + T AS +D + V
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
+ ++ ++ +Q H+ VN I + PSG L + S D TLKI + + I+ LQ H ++
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
T+ +S G A+ ++ ++L +FD
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWRTNFD 302
Score = 89.0 bits (219), Expect = 1e-17
Identities = 58/215 (26%), Positives = 104/215 (48%), Gaps = 11/215 (5%)
Query: 364 KQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
++ F H A +D N A+ S D + + + GH + V ++++ P
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 423 SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASAS 482
G LLAS S D T+++W + + +AH + ++ +S G LA+AS
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121
Query: 483 FDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHS 542
D ++++W + R ++L +H V FSPDG+ + S S DK + IW+T + V++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 543 YRGTGGIFE-VCWNARGDKVGASASDGSVCVLDLR 576
+ + G V +N G + ++ SD +V V D+R
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 124 bits (310), Expect = 3e-28
Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)
Query: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229
S Q+P+KN + E +N+A S+ HA +DG V ++ + K LR
Sbjct: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365
Query: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
GH +F C + P +LLA+ S D T ++W++N + + P
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 410
Query: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343
N+ V SL W G +A G+ A IW + G + +H IF + W+ K +
Sbjct: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470
Query: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399
++ I G+ ++ H A DW QNN + T++ ++
Sbjct: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529
Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
D+P+K F GHT +V +KW P +L S SDD T++IW Q+ CI+ L H +
Sbjct: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589
Query: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518
+ W+ P +L S S+D T+++WD G C T+ H VY + P
Sbjct: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641
Query: 519 Y-LASGSFDKCVHIWN 533
+ +AS S D V +W+
Sbjct: 642 FTMASCSRDSTVRLWS 657
Score = 86.3 bits (212), Expect = 7e-17
Identities = 65/256 (25%), Positives = 116/256 (45%), Gaps = 35/256 (13%)
Query: 302 LLATGSYDGFARIWTEDGNLAS-TLGQHKGPIFALKWNRKGNYILSAGVDKT-TIIWDAH 359
LLAT S+DG ++W + A T ++G I++L W G ++ G + IW+
Sbjct: 384 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 443
Query: 360 TGEAKQQFPFHSAPALD-VDWQNNTT--FASCSTD-MCIHVCRLGCDRPVKTFQG----- 410
G+ Q+F H + + W + + A+CS+D CI ++T G
Sbjct: 444 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 493
Query: 411 --HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPT 465
H V W + ++A+ +D ++++ + + + H +++ +KWSP
Sbjct: 494 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553
Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA-SGS 524
+L S S D TVR+WD + C + L H PV + ++ + YL SGS
Sbjct: 554 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 605
Query: 525 FDKCVHIWNTQSGNLV 540
+D + +W+T+ G V
Sbjct: 606 WDYTIKVWDTREGTCV 621
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)
Query: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
DM K W +++ H + I+ K+ P P +LA+ASFD T+++WDI
Sbjct: 354 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399
Query: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549
+T ++ +YS++++P G +A G+ IWN Q G ++ + GT GI
Sbjct: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459
Query: 550 FEVCWNARGDKVGASASDGSVCVL 573
F + W+ + K A+ S C++
Sbjct: 460 FCIAWSHKDSKRIATCSSDGFCII 483
Score = 34.7 bits (78), Expect = 0.25
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556
+++H++ + ++++ P L ASGS D V IWN ++ T GI CWNA
Sbjct: 55 MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 114
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 124 bits (310), Expect = 3e-28
Identities = 104/376 (27%), Positives = 166/376 (44%), Gaps = 49/376 (13%)
Query: 183 SHQNPSKNREATVNGE--------ENRAHSVN-NHAKPMEIDGEV---EIPSSKATVLR- 229
S Q+P+KN + E +N+A S+ HA +DG V ++ + K LR
Sbjct: 330 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 389
Query: 230 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
GH +F C + P +LLA+ S D T ++W++N + + P
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLT---------------AVYTSPG 434
Query: 288 NKDVT-SLDWNTNG-TLLATGSYDGFARIWT-EDGNLASTLGQH-KGPIFALKWNRKGNY 343
N+ V SL W G +A G+ A IW + G + +H IF + W+ K +
Sbjct: 435 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 494
Query: 344 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCS---TDMCIHVCRL 399
++ I G+ ++ H A DW QNN + T++ ++
Sbjct: 495 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 553
Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
D+P+K F GHT +V +KW P +L S SDD T++IW Q+ CI+ L H +
Sbjct: 554 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 613
Query: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518
+ W+ P +L S S+D T+++WD G C T+ H VY + P
Sbjct: 614 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 665
Query: 519 Y-LASGSFDKCVHIWN 533
+ +AS S D V +W+
Sbjct: 666 FTMASCSRDSTVRLWS 681
Score = 86.3 bits (212), Expect = 7e-17
Identities = 65/256 (25%), Positives = 116/256 (45%), Gaps = 35/256 (13%)
Query: 302 LLATGSYDGFARIWTEDGNLAS-TLGQHKGPIFALKWNRKGNYILSAGVDKT-TIIWDAH 359
LLAT S+DG ++W + A T ++G I++L W G ++ G + IW+
Sbjct: 408 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 467
Query: 360 TGEAKQQFPFHSAPALD-VDWQNNTT--FASCSTD-MCIHVCRLGCDRPVKTFQG----- 410
G+ Q+F H + + W + + A+CS+D CI ++T G
Sbjct: 468 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 517
Query: 411 --HTNEVNAIKWDPSGM-LLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPT 465
H V W + ++A+ +D ++++ + + + H +++ +KWSP
Sbjct: 518 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 577
Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLA-SGS 524
+L S S D TVR+WD + C + L H PV + ++ + YL SGS
Sbjct: 578 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 629
Query: 525 FDKCVHIWNTQSGNLV 540
+D + +W+T+ G V
Sbjct: 630 WDYTIKVWDTREGTCV 645
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)
Query: 433 DMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492
DM K W +++ H + I+ K+ P P +LA+ASFD T+++WDI
Sbjct: 378 DMGAKKWDFLRDL------GHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 423
Query: 493 ERGVCTHTLTKHQEPVYSVAFSPDG-KYLASGSFDKCVHIWNTQSGNLVHSY--RGTGGI 549
+T ++ +YS++++P G +A G+ IWN Q G ++ + GT GI
Sbjct: 424 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 483
Query: 550 FEVCWNARGDKVGASASDGSVCVL 573
F + W+ + K A+ S C++
Sbjct: 484 FCIAWSHKDSKRIATCSSDGFCII 507
Score = 34.7 bits (78), Expect = 0.25
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 4/60 (6%)
Query: 501 LTKHQEPVYSVAFSPDGKYL-ASGSFDKCVHIWNTQSGNLVHSYRGTGGI---FEVCWNA 556
+++H++ + ++++ P L ASGS D V IWN ++ T GI CWNA
Sbjct: 79 MSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWCWNA 138
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 4e-28
Identities = 77/263 (29%), Positives = 127/263 (48%), Gaps = 15/263 (5%)
Query: 289 KDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
K V+S+ ++ NG LA+ S D +IW DG T+ HK I + W+ N ++SA
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
DKT IWD +G+ + HS ++ + S S D + + + + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPT 465
T H++ V+A+ ++ G L+ S S D +IW C+ L N + +K+SP
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLAS 522
G + +A+ D+T++LWD +G C T T H+ Y + + GK++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 523 GSFDKCVHIWNTQSGNLVHSYRG 545
GS D V+IWN Q+ +V +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299
Score = 117 bits (293), Expect = 3e-26
Identities = 63/227 (27%), Positives = 112/227 (49%), Gaps = 11/227 (4%)
Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
L TL H + ++K++ G ++ S+ DK IW A+ G+ ++ H DV W
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
+++ S S D + + + + +KT +GH+N V ++P L+ S S D +++IW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
+K C+ L AH+ + + ++ G ++ S+S+D R+WD G C
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207
Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
TL P S V FSP+GKY+ + + D + +W+ G + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Score = 108 bits (270), Expect = 1e-23
Identities = 81/314 (25%), Positives = 135/314 (42%), Gaps = 29/314 (9%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L GH V ++P + LAS S D +IW + G + + GH +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI------SGHKL-- 88
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 346
++ + W+++ LL + S D +IW G TL H +F +N + N I+S
Sbjct: 89 --GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPV 405
D++ IWD TG+ + P HS P V + ++ + S S D + + +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 406 KTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTI--KW 462
KT N V+ +K+ P+G + + + D TLK+W + C+ H E Y I +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 463 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
S TG + S S D+ V +W+++ L H + V S A P +AS
Sbjct: 267 SVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 523 GSF--DKCVHIWNT 534
+ DK + +W +
Sbjct: 319 AALENDKTIKLWKS 332
Score = 92.4 bits (228), Expect = 1e-18
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
T GHT V+++K+ P+G LAS S D +KIW + H I + WS
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS--- 96
Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
+ + +L SAS D T+++WD+ G C TL H V+ F+P + SGSFD
Sbjct: 97 ------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
+ V IW+ ++G + + + + V +N G + +S+ DG + D
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 10/128 (7%)
Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
L H K + ++K+SP G LAS+S D +++W G T++ H+ +
Sbjct: 41 LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
VA+S D L S S DK + IW+ SG + + +G C +N + + + + + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 569 SVCVLDLR 576
SV + D++
Sbjct: 152 SVRIWDVK 159
Score = 50.1 bits (118), Expect = 6e-06
Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 500 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG-GIFEVCWNARG 558
TL H + V SV FSP+G++LAS S DK + IW G + G GI +V W++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 559 DKVGASASDGSVCVLDL 575
+ + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 4e-28
Identities = 77/263 (29%), Positives = 127/263 (48%), Gaps = 15/263 (5%)
Query: 289 KDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSA 347
K V+S+ ++ NG LA+ S D +IW DG T+ HK I + W+ N ++SA
Sbjct: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
Query: 348 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVK 406
DKT IWD +G+ + HS ++ + S S D + + + + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPT 465
T H++ V+A+ ++ G L+ S S D +IW C+ L N + +K+SP
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
Query: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLAS 522
G + +A+ D+T++LWD +G C T T H+ Y + + GK++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 523 GSFDKCVHIWNTQSGNLVHSYRG 545
GS D V+IWN Q+ +V +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299
Score = 117 bits (293), Expect = 3e-26
Identities = 63/227 (27%), Positives = 112/227 (49%), Gaps = 11/227 (4%)
Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
L TL H + ++K++ G ++ S+ DK IW A+ G+ ++ H DV W
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
+++ S S D + + + + +KT +GH+N V ++P L+ S S D +++IW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
+K C+ L AH+ + + ++ G ++ S+S+D R+WD G C
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207
Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
TL P S V FSP+GKY+ + + D + +W+ G + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Score = 108 bits (270), Expect = 1e-23
Identities = 81/314 (25%), Positives = 135/314 (42%), Gaps = 29/314 (9%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L GH V ++P + LAS S D +IW + G + + GH +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTI------SGHKL-- 88
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILS 346
++ + W+++ LL + S D +IW G TL H +F +N + N I+S
Sbjct: 89 --GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPV 405
D++ IWD TG+ + P HS P V + ++ + S S D + + +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 406 KTFQGHTN-EVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTI--KW 462
KT N V+ +K+ P+G + + + D TLK+W + C+ H E Y I +
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 463 SPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLAS 522
S TG + S S D+ V +W+++ L H + V S A P +AS
Sbjct: 267 SVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 523 GSF--DKCVHIWNT 534
+ DK + +W +
Sbjct: 319 AALENDKTIKLWKS 332
Score = 92.4 bits (228), Expect = 1e-18
Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
T GHT V+++K+ P+G LAS S D +KIW + H I + WS
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS--- 96
Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
+ + +L SAS D T+++WD+ G C TL H V+ F+P + SGSFD
Sbjct: 97 ------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
+ V IW+ ++G + + + + V +N G + +S+ DG + D
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 61.2 bits (147), Expect = 2e-09
Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 10/128 (7%)
Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
L H K + ++K+SP G LAS+S D +++W G T++ H+ +
Sbjct: 41 LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
VA+S D L S S DK + IW+ SG + + +G C +N + + + + + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 569 SVCVLDLR 576
SV + D++
Sbjct: 152 SVRIWDVK 159
Score = 50.1 bits (118), Expect = 6e-06
Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 1/77 (1%)
Query: 500 TLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG-GIFEVCWNARG 558
TL H + V SV FSP+G++LAS S DK + IW G + G GI +V W++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 559 DKVGASASDGSVCVLDL 575
+ + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 123 bits (308), Expect = 5e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 285 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 338
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
Query: 339 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 398
GNY+ SA D TT IW K Q F
Sbjct: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 455
V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E C+ L +H +
Sbjct: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
Query: 456 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 513
++ + W P S +LASAS+D TV+L+ E VC TL H+ V+S+AF
Sbjct: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
Query: 514 SPDGKYLASGSFDKCVHIW 532
P G+ LAS S D+ V IW
Sbjct: 203 DPSGQRLASCSDDRTVRIW 221
Score = 103 bits (256), Expect = 6e-22
Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
Query: 292 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
+ W+ G LA+ S+D IW +D +TL H+ + ++ W GN + +
Sbjct: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
Query: 349 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 404
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
Query: 405 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 447
V T +GH + V ++ +DPSG LASCSDD T++IW +Q V CI
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
Query: 448 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 497
L H++ IY I W A LA+A D +R++ + +
Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
Query: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 535
H H + V VA++P + LAS S D V W Q
Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
Score = 86.7 bits (213), Expect = 5e-17
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)
Query: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
Query: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 342
+DV + W+ + LLA+ SYD +++ E D +TL H+ +++L ++ G
Sbjct: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
Query: 343 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 385
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
Query: 386 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 435
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
Query: 436 LKIWSMKQ 443
+ W ++
Sbjct: 328 VAFWKYQR 335
Score = 77.4 bits (189), Expect = 3e-14
Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)
Query: 383 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
T ASC D I + D + +GH V + W P G LAS S D T IW
Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Query: 440 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 495
Q+ C+ L+ H E+ ++ W+P+G +LA+ S D +V +W+++
Sbjct: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139
Query: 496 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 551
C L H + V V + P + LAS S+D V ++ + + V G ++
Sbjct: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 552 VCWNARGDKVGASASDGSV 570
+ ++ G ++ + + D +V
Sbjct: 200 LAFDPSGQRLASCSDDRTV 218
Score = 31.6 bits (70), Expect = 2.1
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 511 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 566
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 567 DGSVCV 572
D + C+
Sbjct: 82 DATTCI 87
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 120 bits (300), Expect = 4e-27
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 340
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
Query: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400
Y+ S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Query: 401 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 426
+T QGH + VN + D G L
Sbjct: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
Query: 427 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
L S SDD TL +WS + + + + H I + +SP + +
Sbjct: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
Query: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
Query: 538 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
L G ++ V W+ G +V + D
Sbjct: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
Score = 73.6 bits (179), Expect = 5e-13
Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)
Query: 228 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
Query: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 328
H + VT L W +G LL + S D ++W DG L TL H
Sbjct: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
Query: 329 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 358
+G + LK Y ++S D T +W A
Sbjct: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 417
+ + H A V + ++ AS S D I + + + + +GH V
Sbjct: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
I W LL S S D TLK+W +K + DL H E+Y + WSP G
Sbjct: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
Query: 478 LASASFDSTVRLW 490
+AS D +R+W
Sbjct: 471 VASGGKDKCLRIW 483
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)
Query: 323 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 382
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
Query: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
Query: 443 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 501
+ L H+K I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
Query: 502 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 547
T H + V + + DG L S S D+ + +W G L + +G G
Sbjct: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Score = 65.1 bits (157), Expect = 2e-10
Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 446 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 505
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
Query: 506 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 558
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
Query: 559 DKVGASASDGSVCVLD 574
V +S+ DGSV + D
Sbjct: 217 RYVASSSKDGSVRIWD 232
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 119 bits (298), Expect = 8e-27
Identities = 65/227 (28%), Positives = 115/227 (50%), Gaps = 11/227 (4%)
Query: 321 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380
L TL H + ++K++ G ++ S+ D+ IIW A+ G+ ++ H+ DV W
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 381 NNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
++++ S S D + + + + +KT +GH+N V ++P L+ S S D T+KIW
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTH 499
+K C+ L AH+ + + ++ +G ++ S S+D R+WD G C
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGS---------LIVSGSYDGLCRIWDAASGQCLK 203
Query: 500 TLTKHQEPVYS-VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545
TL P S V FSP+GKY+ + + D + +W+ G + +Y G
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Score = 116 bits (290), Expect = 6e-26
Identities = 76/261 (29%), Positives = 125/261 (47%), Gaps = 15/261 (5%)
Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
V+S+ ++ NG LA+ S D IW DG TL H I + W+ + ++SA
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCDRPVKTF 408
DKT +WD +G+ + HS ++ + S S D + + + + +KT
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL-QAHNKEIYTIKWSPTGP 467
H++ V+A+ ++ SG L+ S S D +IW C+ L N + +K+SP G
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223
Query: 468 ATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFS---PDGKYLASGS 524
+ +A+ D+T++LWD RG C T T H+ Y + + GK++ SGS
Sbjct: 224 ---------YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274
Query: 525 FDKCVHIWNTQSGNLVHSYRG 545
D V+IWN Q+ +V +G
Sbjct: 275 EDNLVYIWNLQTKEIVQKLQG 295
Score = 100 bits (249), Expect = 4e-21
Identities = 67/221 (30%), Positives = 107/221 (48%), Gaps = 24/221 (10%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 286
L+GH + VF C +NP S+L+ SGS D T +IW + C++ H P
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK-----------CLKTLSAHSDP 169
Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTL-GQHKGPIFALKWNRKGNYI 344
V+++ +N +G+L+ +GSYDG RIW G TL P+ +K++ G YI
Sbjct: 170 ----VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225
Query: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT----FASCSTDMCIHVCRLG 400
L+A +D T +WD G + + H + + T S S D +++ L
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 285
Query: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCS--DDMTLKIW 439
V+ QGHT+ V + P+ L+AS + +D T+K+W
Sbjct: 286 TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 92.4 bits (228), Expect = 1e-18
Identities = 54/169 (31%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTG 466
T GHT V+++K+ P+G LAS S D + IW L HN EI + WS
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS--- 92
Query: 467 PATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFD 526
+ + L SAS D T++LWD+ G C TL H V+ F+P + SGSFD
Sbjct: 93 ------SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 527 KCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLD 574
+ V IW ++G + + + + V +N G + + + DG + D
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 51.6 bits (122), Expect = 2e-06
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 10/128 (7%)
Query: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
L H + + ++K+SP G LAS+S D + +W G TL H +
Sbjct: 37 LVGHTEAVSSVKFSPNGE---------WLASSSADRLIIIWGAYDGKYEKTLYGHNLEIS 87
Query: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVC-WNARGDKVGASASDG 568
VA+S D L S S DK + +W+ +SG + + +G C +N + + + + D
Sbjct: 88 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDE 147
Query: 569 SVCVLDLR 576
+V + +++
Sbjct: 148 TVKIWEVK 155
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 115 bits (289), Expect = 8e-26
Identities = 83/318 (26%), Positives = 134/318 (42%), Gaps = 67/318 (21%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L GH S V ++PV ++ S S D+T ++W+ G + L+ GH
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK------GH---- 149
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDG-NLASTLGQHKGPIFALKWNRKGNYILS 346
V + ++ +G LLA+ S D ++W G T+ H + ++ G++I+S
Sbjct: 150 TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVS 209
Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVK 406
A DKT +W+ TG VK
Sbjct: 210 ASRDKTIKMWEVQTGYC-----------------------------------------VK 228
Query: 407 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP-- 464
TF GH V ++ + G L+ASCS+D T+++W + + C +L+ H + I W+P
Sbjct: 229 TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPES 288
Query: 465 --------TGPATSNPNS-NIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP 515
TG T L S S D T+++WD+ G+C TL H V V F
Sbjct: 289 SYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS 348
Query: 516 DGKYLASGSFDKCVHIWN 533
GK++ S + DK + +W+
Sbjct: 349 GGKFILSCADDKTLRVWD 366
Score = 97.4 bits (241), Expect = 3e-20
Identities = 64/274 (23%), Positives = 127/274 (46%), Gaps = 31/274 (11%)
Query: 325 LGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN-T 383
L H+ P+ + ++ + ++SA D T +WD TG+ ++ H+ D+ + ++
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 384 TFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443
ASCS DM I + ++T GH + V+++ P+G + S S D T+K+W ++
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTK 503
C+ H + + ++ + G ++AS S D TVR+W + C L +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGT---------LIASCSNDQTVRVWVVATKECKAELRE 274
Query: 504 HQEPVYSVAFSPD--------------------GKYLASGSFDKCVHIWNTQSGNLVHSY 543
H+ V ++++P+ G +L SGS DK + +W+ +G + +
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334
Query: 544 RG-TGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
G + V +++ G + + A D ++ V D +
Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
Score = 90.1 bits (222), Expect = 5e-18
Identities = 69/287 (24%), Positives = 117/287 (40%), Gaps = 47/287 (16%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 286
L+GH V +++ LLAS S D T ++W+ CIR GHD
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192
Query: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYIL 345
+V+S+ NG + + S D ++W + G T H+ + ++ N+ G I
Sbjct: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 346 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCST--------------- 390
S D+T +W T E K + H + W ++++S S
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
Query: 391 ------DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444
D I + + + T GH N V + + G + SC+DD TL++W K +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD 491
C+ L AH + ++ + T P + + S D TV++W+
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408
Score = 36.6 bits (83), Expect = 0.065
Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNAR 557
+ L+ H+ PV V F P + S S D + +W+ ++G+ + +G T + ++ ++
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 558 GDKVGASASDGSVCVLDLR 576
G + + ++D ++ + D +
Sbjct: 162 GKLLASCSADMTIKLWDFQ 180
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 115 bits (287), Expect = 1e-25
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)
Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
VT +D++ N LA+GS D +W + + A HK + + ++ G+ + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408
DKT IW + F H+A V + + +F + S D + V + + +
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
H N V K+ P G L+ S SDD T+K+W C+H H + + + P+G
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524
+A+A D+TV++WD+ TH L +H + V ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 113 bits (282), Expect = 5e-25
Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)
Query: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
+GH V ++ + LASGS DS +W++ S R GH
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
Query: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346
KD VT ++++ +G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
V ++ H V + + PSG +A+ D T+K+W ++ + Q H+ +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
+ + P+G L +AS DST+++ D+ G +TL HQ P +VAFS G+Y
Sbjct: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
Query: 520 LASGSFDKCVHIWNT 534
ASG D+ V +W +
Sbjct: 286 FASGGSDEQVMVWKS 300
Score = 100 bits (248), Expect = 5e-21
Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)
Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
P S+A GH+ V ++P LLASGS D T RIW N G ST V R
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100
Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
V S+ + ++G T S D ++W T +L QH + K++
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
G I+SA DKT +WD + E + H VD+ + T A+ D + V
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
+ R ++ +Q H+ VN + + PSG L + S D TLKI + + ++ L H
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
T+ +S TG A+ + +M+ ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 97.1 bits (240), Expect = 4e-20
Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)
Query: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
++ F H VD+ NT AS S D C+ V + F GH + V + + P
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
SG LLAS S D T++IW ++K E + +AH + ++ + G + +
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
AS D TV++W R +L++H V FSPDG+ + S S DK V +W+ S V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576
HSY GG + V ++ G + A+ D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Score = 92.4 bits (228), Expect = 1e-18
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)
Query: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376
ED +L H+ + + ++ + S +D ++W +F H
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
+K+W+ ++ + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554
C H+ +H V V F P G +A+ D V +W+ ++ L+ Y+ + + + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 555 NARGDKVGASASDGSVCVLDL 575
+ G+ + ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 115 bits (287), Expect = 1e-25
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 20/289 (6%)
Query: 291 VTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGNYILSAGV 349
VT +D++ N LA+GS D +W + + A HK + + ++ G+ + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 350 DKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTF 408
DKT IW + F H+A V + + +F + S D + V + + +
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 409 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 468
H N V K+ P G L+ S SDD T+K+W C+H H + + + P+G
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 469 TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE----PVYSVAFSPDGKYLASGS 524
+A+A D+TV++WD+ TH L +H + V ++F P G YL + S
Sbjct: 202 ---------IAAAGMDNTVKVWDVR----THRLLQHYQLHSAAVNGLSFHPSGNYLITAS 248
Query: 525 FDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCV 572
D + I + G L+++ G G V ++ G+ + SD V V
Sbjct: 249 SDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Score = 113 bits (282), Expect = 5e-25
Identities = 87/315 (27%), Positives = 145/315 (46%), Gaps = 39/315 (12%)
Query: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
+GH V ++ + LASGS DS +W++ S R GH
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----------YRFTGH----- 60
Query: 289 KD-VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILS 346
KD VT ++++ +G LLA+GS D RIW + ST+ + H + ++ + G ++
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 347 AGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFA-------SCSTDMCIHVCRL 399
A DKT +W H +Q+F F + ++W F+ S S D + +
Sbjct: 121 ASDDKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
Query: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
V ++ H V + + PSG +A+ D T+K+W ++ + Q H+ +
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKY 519
+ + P+G L +AS DST+++ D+ G +TL HQ P +VAFS G+Y
Sbjct: 235 LSFHPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285
Query: 520 LASGSFDKCVHIWNT 534
ASG D+ V +W +
Sbjct: 286 FASGGSDEQVMVWKS 300
Score = 100 bits (248), Expect = 5e-21
Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)
Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
P S+A GH+ V ++P LLASGS D T RIW N G ST V R
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 100
Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
V S+ + ++G T S D ++W T +L QH + K++
Sbjct: 101 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155
Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
G I+SA DKT +WD + E + H VD+ + T A+ D + V
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
+ R ++ +Q H+ VN + + PSG L + S D TLKI + + ++ L H
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
T+ +S TG A+ + +M+ ++FD
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 97.1 bits (240), Expect = 4e-20
Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 15/217 (6%)
Query: 364 KQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDP 422
++ F H VD+ NT AS S D C+ V + F GH + V + + P
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 423 SGMLLASCSDDMTLKIW--SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
SG LLAS S D T++IW ++K E + +AH + ++ + G + +
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120
Query: 481 ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV 540
AS D TV++W R +L++H V FSPDG+ + S S DK V +W+ S V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 541 HSYRGTGG-IFEVCWNARGDKVGASASDGSVCVLDLR 576
HSY GG + V ++ G + A+ D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Score = 92.4 bits (228), Expect = 1e-18
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 11/261 (4%)
Query: 317 EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 376
ED +L H+ + + ++ + S +D ++W +F H
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 377 VDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
V++ + AS S D + + F+ HT V ++ + G + SDD T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 436 LKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
+K+W+ ++ + L H + K+SP G ++ SAS D TV+LWD
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177
Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR-GTGGIFEVCW 554
C H+ +H V V F P G +A+ D V +W+ ++ L+ Y+ + + + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 555 NARGDKVGASASDGSVCVLDL 575
+ G+ + ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 113 bits (283), Expect = 4e-25
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)
Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 330
Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
TGE H++ + S S D + V + + + GH V +
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389
Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
++D G + S + D +K+W + E C+H LQ H +Y++++ I +
Sbjct: 390 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 436
Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
S S D+++R+WD+E G C HTLT HQ + + L SG+ D V IW+ ++G
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 494
Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
+ + +G C + V S+ DG+V + DL+
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 534
Score = 78.2 bits (191), Expect = 2e-14
Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)
Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
GE++ P VL+GH+ V C + + SGS D+T ++W+ V
Sbjct: 250 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 293
Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
C+R GH T W++ ++ +GS D ++W E G TL H
Sbjct: 294 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 345
Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
+ + + K ++S D T +WD TG+ H A V + S + D
Sbjct: 346 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 402
Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
+ V + + T QGHTN V ++++D G+ + S S D ++++W ++ CIH L
Sbjct: 403 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 460
Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
H +I+ IK PN + +
Sbjct: 461 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 520
Query: 480 SASFDSTVRLWDIERG 495
++S D TV+LWD++ G
Sbjct: 521 TSSDDGTVKLWDLKTG 536
Score = 59.7 bits (143), Expect = 7e-09
Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
+ SGS D+T R+W++ G +++ H C++ G V S
Sbjct: 356 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 398
Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
G+YD ++W E TL H +++L+++ G +++S +D + +WD T
Sbjct: 399 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 452
Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
G H + ++ ++N S + D + + + + ++T QG H + V
Sbjct: 453 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 511
Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
++++ + ++ +S DD T+K+W +K I +L
Sbjct: 512 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 542
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 419 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 461
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
++ +TS +L +G+ D +IW + G TL +H+ + L++N+ N+
Sbjct: 462 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 518
Query: 344 ILSAGVDKTTIIWDAHTGE 362
++++ D T +WD TGE
Sbjct: 519 VITSSDDGTVKLWDLKTGE 537
Score = 33.1 bits (74), Expect = 0.71
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
T+ G NR +S+ H +D + + + L GH+S ++
Sbjct: 418 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 475
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
L SG+ DST +IW++ C++ VT L +N N + T
Sbjct: 476 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 522
Query: 307 SYDGFARIW 315
S DG ++W
Sbjct: 523 SDDGTVKLW 531
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 113 bits (283), Expect = 4e-25
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)
Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
TGE H++ + S S D + V + + + GH V +
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
++D G + S + D +K+W + E C+H LQ H +Y++++ I +
Sbjct: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
S S D+++R+WD+E G C HTLT HQ + + L SG+ D V IW+ ++G
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
+ + +G C + V S+ DG+V + DL+
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
Score = 78.2 bits (191), Expect = 2e-14
Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)
Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
GE++ P VL+GH+ V C + + SGS D+T ++W+ V
Sbjct: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411
Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
C+R GH T W++ ++ +GS D ++W E G TL H
Sbjct: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463
Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
+ + + K ++S D T +WD TG+ H A V + S + D
Sbjct: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520
Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
+ V + + T QGHTN V ++++D G+ + S S D ++++W ++ CIH L
Sbjct: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 578
Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
H +I+ IK PN + +
Sbjct: 579 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 638
Query: 480 SASFDSTVRLWDIERG 495
++S D TV+LWD++ G
Sbjct: 639 TSSDDGTVKLWDLKTG 654
Score = 59.7 bits (143), Expect = 7e-09
Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
+ SGS D+T R+W++ G +++ H C++ G V S
Sbjct: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516
Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
G+YD ++W E TL H +++L+++ G +++S +D + +WD T
Sbjct: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570
Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
G H + ++ ++N S + D + + + + ++T QG H + V
Sbjct: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
++++ + ++ +S DD T+K+W +K I +L
Sbjct: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
++ +TS +L +G+ D +IW + G TL +H+ + L++N+ N+
Sbjct: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
Query: 344 ILSAGVDKTTIIWDAHTGE 362
++++ D T +WD TGE
Sbjct: 637 VITSSDDGTVKLWDLKTGE 655
Score = 33.1 bits (74), Expect = 0.71
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
T+ G NR +S+ H +D + + + L GH+S ++
Sbjct: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
L SG+ DST +IW++ C++ VT L +N N + T
Sbjct: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640
Query: 307 SYDGFARIW 315
S DG ++W
Sbjct: 641 SDDGTVKLW 649
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 113 bits (283), Expect = 4e-25
Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)
Query: 300 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 358
G + +GS D ++W+ G TL H G +++ + + N I+S D+T +W+A
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 368
Query: 359 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 418
TGE H++ + S S D + V + + + GH V +
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427
Query: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
++D G + S + D +K+W + E C+H LQ H +Y++++ I +
Sbjct: 428 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 474
Query: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
S S D+++R+WD+E G C HTLT HQ + + L SG+ D V IW+ ++G
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 532
Query: 539 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 576
+ + +G C + V S+ DG+V + DL+
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 572
Score = 78.2 bits (191), Expect = 2e-14
Identities = 76/316 (24%), Positives = 127/316 (40%), Gaps = 65/316 (20%)
Query: 216 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 275
GE++ P VL+GH+ V C + + SGS D+T ++W+ V
Sbjct: 288 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 331
Query: 276 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 331
C+R GH T W++ ++ +GS D ++W E G TL H
Sbjct: 332 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 383
Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 391
+ + + K ++S D T +WD TG+ H A V + S + D
Sbjct: 384 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 440
Query: 392 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 451
+ V + + T QGHTN V ++++D G+ + S S D ++++W ++ CIH L
Sbjct: 441 FMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT 498
Query: 452 AHNK---------------------EIYTIKWSPTGPATSNPNSNI-----------MLA 479
H +I+ IK PN + +
Sbjct: 499 GHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVI 558
Query: 480 SASFDSTVRLWDIERG 495
++S D TV+LWD++ G
Sbjct: 559 TSSDDGTVKLWDLKTG 574
Score = 59.7 bits (143), Expect = 7e-09
Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 301
+ SGS D+T R+W++ G +++ H C++ G V S
Sbjct: 394 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 436
Query: 302 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
G+YD ++W E TL H +++L+++ G +++S +D + +WD T
Sbjct: 437 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 490
Query: 361 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 417
G H + ++ ++N S + D + + + + ++T QG H + V
Sbjct: 491 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 549
Query: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
++++ + ++ +S DD T+K+W +K I +L
Sbjct: 550 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 580
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
L+GH + V+ ++ + + SGS D++ R+W++ + CI H +
Sbjct: 457 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 499
Query: 288 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 343
++ +TS +L +G+ D +IW + G TL +H+ + L++N+ N+
Sbjct: 500 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 556
Query: 344 ILSAGVDKTTIIWDAHTGE 362
++++ D T +WD TGE
Sbjct: 557 VITSSDDGTVKLWDLKTGE 575
Score = 33.1 bits (74), Expect = 0.71
Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)
Query: 194 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 246
T+ G NR +S+ H +D + + + L GH+S ++
Sbjct: 456 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 513
Query: 247 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 306
L SG+ DST +IW++ C++ VT L +N N + T
Sbjct: 514 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 560
Query: 307 SYDGFARIW 315
S DG ++W
Sbjct: 561 SDDGTVKLW 569
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 112 bits (281), Expect = 7e-25
Identities = 78/292 (26%), Positives = 127/292 (43%), Gaps = 36/292 (12%)
Query: 244 SDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLL 303
S L+A G DST R+W++ + K + S+ ++ +L+
Sbjct: 482 SSLIAGGFADSTVRVWSV-------------------------TPKKLRSVKQASDLSLI 516
Query: 304 ATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGE 362
S D RI E + L H GP++ ++ NY+LS+ D T +W T
Sbjct: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
Query: 363 AKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWD 421
+ H+ P D + F S D + +P++ F GH +VN ++
Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
Query: 422 PSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASA 481
P+ +A+ S D T+++W + C+ H I+++ +SP G LA+
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR---------FLATG 687
Query: 482 SFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533
+ D V LWDI G+ L H + V S+ FS DG+ LASGS D V +W+
Sbjct: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 90.9 bits (224), Expect = 3e-18
Identities = 58/208 (27%), Positives = 100/208 (48%), Gaps = 36/208 (17%)
Query: 405 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSP 464
+K GH+ V + P L S S+D T+++WS++ C+ + HN ++ ++SP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Query: 465 TGP--------------ATSN--------------------PNSNIMLASASFDSTVRLW 490
G AT + PNSN + A+ S D TVRLW
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV-ATGSADRTVRLW 654
Query: 491 DIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGI 549
D+ G C T H+ P++S+ FSP+G++LA+G+ D V +W+ G +V +G T +
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714
Query: 550 FEVCWNARGDKVGASASDGSVCVLDLRK 577
+ ++ G+ + + + D +V + D K
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 82.8 bits (203), Expect = 8e-16
Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 16/223 (7%)
Query: 219 EIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCI 278
E +S+ +L GH V+ +++P + L S S D T R+W+L +
Sbjct: 530 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLV 579
Query: 279 REGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKW 337
GH+ P V ++ G +G +D AR+W T+ H + ++
Sbjct: 580 GYKGHNYP----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
Query: 338 NRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHV 396
+ NY+ + D+T +WD G + F H P + + N F A+ +TD + +
Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
Query: 397 CRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
+G V +GHT+ V ++++ G +LAS S D T+++W
Sbjct: 696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 30.4 bits (67), Expect = 4.6
Identities = 13/33 (39%), Positives = 21/33 (63%)
Query: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWN 260
L+GH V ++ ++LASGS D+T R+W+
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 105 bits (262), Expect = 1e-22
Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)
Query: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446
SCS DM I LG +QGH V + P + AS S D T ++WS +
Sbjct: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
Query: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506
+ H ++ +K+ +PNSN LA+ S D TVRLW ++G T H+
Sbjct: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
Query: 507 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 565
PV S+AFSP+GKYLAS D+ + +W+ SG L RG T I + ++ + +++
Sbjct: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
Query: 566 SDGSVCVLDLR 576
D SV V D+R
Sbjct: 530 MDNSVRVWDIR 540
Score = 100 bits (248), Expect = 5e-21
Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)
Query: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300
+P S LLA+G +S ++W+L ++ H V ++ + D
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319
Query: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360
L D A G L H GP+++ ++ + +LS D + WD +
Sbjct: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
Query: 361 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419
+ H+ P D+D + FAS S D + P++ + GH +V+ +K
Sbjct: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
Query: 420 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 479
+ P+ LA+ S D T+++WS +Q + H + ++ +SP G LA
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
Query: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 536
SA D ++LWD+ G L H + + S+ FSPD +AS S D V +W+ ++
Sbjct: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 93.6 bits (231), Expect = 4e-19
Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)
Query: 213 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 272
E D E + ++ +LRGH V+ + S L S S D + R W+L G T
Sbjct: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
Query: 273 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 331
VL GH P V LD + A+GS+D AR+W+ D + H
Sbjct: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
Query: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 390
+ +K++ NY+ + DKT +W A G + + F H P L + + N + AS
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450
D + + L K +GHT+ + ++ + P L+AS S D ++++W ++ C
Sbjct: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548
Query: 451 QAHNKEI 457
+ E+
Sbjct: 549 DGSSSEL 555
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/229 (20%), Positives = 79/229 (34%), Gaps = 70/229 (30%)
Query: 415 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 463
+N + P LLA+ D+ +K+WS++ + + H ++ I +
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328
Query: 464 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509
GP S + L S S D ++R WD+ T H PV+
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
Query: 510 S------------------------------------------VAFSPDGKYLASGSFDK 527
V F P+ YLA+GS DK
Sbjct: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDK 448
Query: 528 CVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 575
V +W+ Q GN V + G G + + ++ G + ++ D + + DL
Sbjct: 449 TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497
Score = 32.0 bits (71), Expect = 1.6
Identities = 12/44 (27%), Positives = 24/44 (54%)
Query: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539
+C + ++ + + SPD K LA+G + C+ +W+ +S L
Sbjct: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 105 bits (261), Expect = 1e-22
Identities = 86/399 (21%), Positives = 165/399 (41%), Gaps = 35/399 (8%)
Query: 146 RQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSV 205
+Q+A R + Q + + A A S ++ +++ + + E + H V
Sbjct: 19 KQRALRPVFKKSQQLSYCSTCAEIMATEGLHENETLASLKSEAESLKGKLEEERAKLHDV 78
Query: 206 NNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENS 265
H ++ + L+GH ++V W + S S D +W ++
Sbjct: 79 ELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVW---DSF 135
Query: 266 NGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWT----EDGNL 321
V C V + + +G +A G D ++ ++ N+
Sbjct: 136 TTNKEHAVTMPCTW-----------VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENM 184
Query: 322 AS---TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVD 378
A+ ++ H + A + IL+A D T +WD +G+ Q F H A L +D
Sbjct: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLD 244
Query: 379 W---QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 435
+ TF S D V + + V+ F+ H +++N++++ PSG AS SDD T
Sbjct: 245 LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
Query: 436 LKIWSMK--QEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIE 493
+++ ++ +EV I+ ++ ++ +S +G +L + D T+ +WD+
Sbjct: 305 CRLYDLRADREVAIYSKESIIFGASSVDFSLSGR---------LLFAGYNDYTINVWDVL 355
Query: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
+G L H+ V ++ SPDG SGS+D + +W
Sbjct: 356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 69.3 bits (168), Expect = 9e-12
Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 17/264 (6%)
Query: 324 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 383
TL H + + W + I+S+ D I+WD+ T + + + +
Sbjct: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
Query: 384 TFASCS-TDMCIHVCRLGCDR------PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 436
+C D V L D+ K+ HTN ++A + S M + + S D T
Sbjct: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
Query: 437 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 496
+W ++ + H ++ + +P+ + S D +WD+ G
Sbjct: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT-------FVSGGCDKKAMVWDMRSGQ 272
Query: 497 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIF---EVC 553
C H+ + SV + P G ASGS D +++ ++ V Y IF V
Sbjct: 273 CVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVD 332
Query: 554 WNARGDKVGASASDGSVCVLDLRK 577
++ G + A +D ++ V D+ K
Sbjct: 333 FSLSGRLLFAGYNDYTINVWDVLK 356
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 103 bits (256), Expect = 6e-22
Identities = 79/291 (27%), Positives = 133/291 (45%), Gaps = 39/291 (13%)
Query: 253 DSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD-VTSLDWNTNGTLLATGSYDGF 311
DS +W++ S R GH KD VT ++++ +G LLA+GS D
Sbjct: 2 DSCLMVWHMKPQSRA----------YRFTGH-----KDAVTCVNFSPSGHLLASGSRDKT 46
Query: 312 ARIWTEDGNLASTLGQ-HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 370
RIW + ST+ + H + ++ + G ++A DKT +W H +Q+F F
Sbjct: 47 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH----RQKFLFS 102
Query: 371 SAPALDVDWQNNTTFA-------SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPS 423
+ ++W F+ S S D + + V ++ H V + + PS
Sbjct: 103 LSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS 160
Query: 424 GMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASF 483
G +A+ D T+K+W ++ + Q H+ + + + P+G L +AS
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN---------YLITASS 211
Query: 484 DSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNT 534
DST+++ D+ G +TL HQ P +VAFS G+Y ASG D+ V +W +
Sbjct: 212 DSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262
Score = 102 bits (255), Expect = 7e-22
Identities = 66/251 (26%), Positives = 111/251 (44%), Gaps = 19/251 (7%)
Query: 328 HKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QNNTTFA 386
HK + + ++ G+ + S DKT IW + F H+A V + + +F
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446
+ S D + V + + + H N V K+ P G L+ S SDD T+K+W C
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
Query: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506
+H H + + + P+G +A+A D+TV++WD+ TH L +H +
Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTC---------IAAAGMDNTVKVWDVR----THRLLQHYQ 188
Query: 507 ----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKV 561
V ++F P G YL + S D + I + G L+++ G G V ++ G+
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
Query: 562 GASASDGSVCV 572
+ SD V V
Sbjct: 249 ASGGSDEQVMV 259
Score = 100 bits (248), Expect = 5e-21
Identities = 78/268 (29%), Positives = 120/268 (44%), Gaps = 18/268 (6%)
Query: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280
P S+A GH+ V ++P LLASGS D T RIW N G ST V R
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW--VPNVKGEST--VFR----- 62
Query: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNR 339
V S+ + ++G T S D ++W T +L QH + K++
Sbjct: 63 -----AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
Query: 340 KGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCR 398
G I+SA DKT +WD + E + H VD+ + T A+ D + V
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIY 458
+ R ++ +Q H+ VN + + PSG L + S D TLKI + + ++ L H
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 459 TIKWSPTGP--ATSNPNSNIMLASASFD 484
T+ +S TG A+ + +M+ ++FD
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVWKSNFD 265
Score = 90.1 bits (222), Expect = 5e-18
Identities = 60/189 (31%), Positives = 93/189 (49%), Gaps = 14/189 (7%)
Query: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW--SMKQEVCIH 448
D C+ V + F GH + V + + PSG LLAS S D T++IW ++K E +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
Query: 449 DLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPV 508
+AH + ++ + G + +AS D TV++W R +L++H V
Sbjct: 61 -FRAHTATVRSVHFCSDGQS---------FVTASDDKTVKVWATHRQKFLFSLSQHINWV 110
Query: 509 YSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG-IFEVCWNARGDKVGASASD 567
FSPDG+ + S S DK V +W+ S VHSY GG + V ++ G + A+ D
Sbjct: 111 RCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 170
Query: 568 GSVCVLDLR 576
+V V D+R
Sbjct: 171 NTVKVWDVR 179
Score = 86.3 bits (212), Expect = 7e-17
Identities = 55/229 (24%), Positives = 102/229 (44%), Gaps = 11/229 (4%)
Query: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRPVKT 407
+D ++W +F H V++ + AS S D + +
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGP 467
F+ HT V ++ + G + SDD T+K+W+ ++ + L H + K+SP G
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 468 ATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDK 527
++ SAS D TV+LWD C H+ +H V V F P G +A+ D
Sbjct: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171
Query: 528 CVHIWNTQSGNLVHSYR-GTGGIFEVCWNARGDKVGASASDGSVCVLDL 575
V +W+ ++ L+ Y+ + + + ++ G+ + ++SD ++ +LDL
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,927,509
Number of Sequences: 37866
Number of extensions: 1044686
Number of successful extensions: 9744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 4764
Number of HSP's gapped (non-prelim): 2301
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.