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Search of human proteins with 213021148
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|213021148 SVOP-like isoform 1 [Homo sapiens]
(492 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|213021148 SVOP-like isoform 1 [Homo sapiens] 967 0.0
gi|33457322 SVOP-like isoform 2 [Homo sapiens] 654 0.0
gi|24308167 SV2 related protein [Homo sapiens] 364 e-100
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 138 1e-32
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 135 1e-31
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 131 1e-30
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 129 5e-30
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 128 1e-29
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 128 1e-29
gi|166064021 solute carrier family 22 (organic anion transporter... 120 4e-27
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 119 6e-27
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 118 1e-26
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 115 7e-26
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 112 8e-25
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 111 1e-24
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens] 108 8e-24
gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens] 105 1e-22
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 104 2e-22
gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens] 103 4e-22
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 102 8e-22
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 102 8e-22
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 98 2e-20
gi|157426885 organic cation transporter like 4 [Homo sapiens] 98 2e-20
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 89 1e-17
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 79 7e-15
gi|148664184 solute carrier family 22, member 10 [Homo sapiens] 71 3e-12
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens] 68 2e-11
gi|211059435 solute carrier family 22, member 24 [Homo sapiens] 68 2e-11
gi|134053883 intestinal facilitative glucose transporter 7 [Homo... 64 3e-10
gi|21553331 solute carrier family 2 (facilitated glucose transpo... 64 4e-10
>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
Length = 492
Score = 967 bits (2499), Expect = 0.0
Identities = 492/492 (100%), Positives = 492/492 (100%)
Query: 1 MATKPTEPVTILSLRKLSLGTAEPQVKEPKTFTVEDAVETIGFGRFHIALFLIMGSTGVV 60
MATKPTEPVTILSLRKLSLGTAEPQVKEPKTFTVEDAVETIGFGRFHIALFLIMGSTGVV
Sbjct: 1 MATKPTEPVTILSLRKLSLGTAEPQVKEPKTFTVEDAVETIGFGRFHIALFLIMGSTGVV 60
Query: 61 EAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLIS 120
EAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLIS
Sbjct: 61 EAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLIS 120
Query: 121 FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVF 180
FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVF
Sbjct: 121 FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVF 180
Query: 181 WLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALA 240
WLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALA
Sbjct: 181 WLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALA 240
Query: 241 TLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIL 300
TLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIL
Sbjct: 241 TLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIL 300
Query: 301 ASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPL 360
ASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPL
Sbjct: 301 ASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPL 360
Query: 361 NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTA 420
NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTA
Sbjct: 361 NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTA 420
Query: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 480
EVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP
Sbjct: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 480
Query: 481 IETKGRALQQIK 492
IETKGRALQQIK
Sbjct: 481 IETKGRALQQIK 492
>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
Length = 340
Score = 654 bits (1687), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 158 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 217
LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV
Sbjct: 6 LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 65
Query: 218 AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 277
AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY
Sbjct: 66 AFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLDAKY 125
Query: 278 LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH 337
LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH
Sbjct: 126 LRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCH 185
Query: 338 MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 397
MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL
Sbjct: 186 MFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL 245
Query: 398 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS 457
IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS
Sbjct: 246 IGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSAS 305
Query: 458 ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 492
ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK
Sbjct: 306 ILGALCLFSSVCVVCAISAFTLPIETKGRALQQIK 340
>gi|24308167 SV2 related protein [Homo sapiens]
Length = 548
Score = 364 bits (934), Expect = e-100
Identities = 182/460 (39%), Positives = 286/460 (62%), Gaps = 7/460 (1%)
Query: 31 TFTVEDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVT 90
TF VEDAVE IGFG+F L ++ G + +AME+M++++++P + CEW+L +WQVAL+T
Sbjct: 67 TFMVEDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLT 126
Query: 91 TMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCG 150
++VF G M S L+G ++D+YGR L IS LW Y+ +L++FAP Y W + LR +VG G
Sbjct: 127 SVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFG 186
Query: 151 VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI 210
+ G Q + + EFLP K R + L +VFW G++ + LA ++P++GWRWL+ ++++
Sbjct: 187 IGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLGWRWLLILSAV 246
Query: 211 PGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFA 270
P ++ V ++PESAR++V +GN A+ATL+R+A N + MP GKL+ E RG+
Sbjct: 247 PLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQEDRGKMR 306
Query: 271 DLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGDSGES 330
DL + TTL +W IW +F+YYG++L + EL + VCG S V E+
Sbjct: 307 DLFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV-------EA 359
Query: 331 QSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI 390
+ C + DY ++ +T+ E + + I+ LGR+ ++++ + LLL I
Sbjct: 360 KCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFI 419
Query: 391 CTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS 450
C L LF+ RA ++ F Y+YT EVYPT RALG+GT + R+GA++ PFI+
Sbjct: 420 CVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIA 479
Query: 451 QVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQ 490
QV++ +S+ L ++S C++ A+++ LPIETKGR LQ+
Sbjct: 480 QVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQE 519
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 138 bits (347), Expect = 1e-32
Identities = 115/436 (26%), Positives = 206/436 (47%), Gaps = 57/436 (13%)
Query: 72 SPVIRCEWQLENWQVAL---VTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFS 128
S I EW L Q L +T F G +V ++ FG L+DR+GR ++LL++++
Sbjct: 125 SSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLG 184
Query: 129 LLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLL 187
L ++ + SY+ F RT+ G ++G + ++ ++ E+L ++R LS FW G ++
Sbjct: 185 LASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVM 243
Query: 188 IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAK 247
++ L +I WRWL+ ++P I++ ++PESAR+ ++ G+ + A L A+
Sbjct: 244 LLALVGYLIR--DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCAR 301
Query: 248 MNRSVMPEGKLVEPVLEK---------RGRFADLLDAKYLR-TTLQIWVIWLGISFAYYG 297
+N + E + + K R + DL LR +L V+W G++F+YYG
Sbjct: 302 LNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYG 361
Query: 298 VILASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIAL 357
+ L + L + Y+T ++ E+
Sbjct: 362 LSLDVSGL----------------------------------GLNVYQTQLLFGAVELPS 387
Query: 358 NPLNILGINFLGRRLSLSITMGCTALFF---LLLNICTSSAGLIGFLFMLRALVAANFNT 414
L L + + GRRL+ + T+ TAL F LL++ S + M +A A F T
Sbjct: 388 KLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTT 446
Query: 415 VYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAI 474
Y++T+E+YPT +R GMG + + R+G +AP ++ +L + + + ++ A
Sbjct: 447 AYLFTSELYPTVLRQTGMGLTALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAG 505
Query: 475 SAFTLPIETKGRALQQ 490
+A LP ET+ L +
Sbjct: 506 TALLLP-ETRQAQLPE 520
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 135 bits (339), Expect = 1e-31
Identities = 112/430 (26%), Positives = 204/430 (47%), Gaps = 57/430 (13%)
Query: 78 EWQLENWQVAL---VTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
+W L Q L +T F G +V ++ FG L+DR+GR ++LL++++ L ++ +
Sbjct: 133 QWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 192
Query: 135 PSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
SY+ F RT+ G ++G + ++ ++ E+L ++R LS FW G ++++ L
Sbjct: 193 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLALVG 251
Query: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253
+I WRWL+ ++P I++ ++PESAR+ ++ G+ + A L A++N +
Sbjct: 252 YLIR--DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 309
Query: 254 PEGKLVEPVLEK---------RGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASA 303
E + + K R + DL LR +L V+W G++F+YYG+ L +
Sbjct: 310 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVS 369
Query: 304 ELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNIL 363
L + Y+T ++ E+ L L
Sbjct: 370 GL----------------------------------GLNVYQTQLLFGAVELPSKLLVYL 395
Query: 364 GINFLGRRLSLSITMGCTALFF---LLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTA 420
+ + GRRL+ + T+ TAL F LL++ S + M +A A F T Y++T+
Sbjct: 396 SVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTS 454
Query: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 480
E+YPT +R GMG + + R+G +AP ++ +L + + + ++ A +A LP
Sbjct: 455 ELYPTVLRQTGMGLTALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLP 513
Query: 481 IETKGRALQQ 490
ET+ L +
Sbjct: 514 -ETRQAQLPE 522
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 131 bits (330), Expect = 1e-30
Identities = 117/398 (29%), Positives = 174/398 (43%), Gaps = 65/398 (16%)
Query: 75 IRCEWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLT 131
I EW L +++V+ ++ F G V I FG L+DR+GR K+ L F F++
Sbjct: 97 IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIAN 156
Query: 132 SFAPSYIWFVFLRTMVGCGVSGHSQ-GLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIG 190
F+PSY +F R +VG G S ++ E + T Y + +F+ G
Sbjct: 157 GFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL 216
Query: 191 LASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR 250
L I WR L + ++ G ++ + FIPES R+ S G A L +AK NR
Sbjct: 217 LGYFIR---SWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNR 273
Query: 251 SVMPEGKLVEPV---LEKRGRFADLLDAKYLRT-TLQIWVIWLGISFAYYGVILASAELL 306
+ L P + G F DL + L TL + IW S YYG+ L++ +L
Sbjct: 274 KLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDL- 332
Query: 307 ERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGIN 366
GG S Y + +S + EI PL I IN
Sbjct: 333 -----------------GG----------------SIYANLALSGLIEIPSYPLCIYLIN 359
Query: 367 --FLGRRLSLSITM-----GCTALFFL--------LLNICTSSAGLIGFLFMLRALVAAN 411
+ GR+ +LS + C + FL + + S L+G L ++A
Sbjct: 360 QKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKL-----TISAA 414
Query: 412 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 449
FN VYIYT+E+YPT +R +G+GT R+G ++APFI
Sbjct: 415 FNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 452
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 129 bits (325), Expect = 5e-30
Identities = 107/426 (25%), Positives = 200/426 (46%), Gaps = 61/426 (14%)
Query: 78 EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
EW L ++W+ L ++ F G ++ S + G L+DR+GR +L ++ FS L F+
Sbjct: 131 EWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFS 190
Query: 135 PSYIWFVFLRTMVGCG-VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
++ FV L +VG G +S + ++ TE L R L + A +++ L +
Sbjct: 191 KNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFA 250
Query: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253
I WR L+ ++PG++ + + FIPES R+ +S G A + + AK N V+
Sbjct: 251 YFIR--DWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVV 308
Query: 254 P----EGKLVEPVLEKRGRFADLLDAKYLRT------TLQIWVIWLGISFAYYGVILASA 303
P + ++ + K+ + ++LD LRT T+ ++W+ IS Y+G+ L +
Sbjct: 309 PSTIFDPSELQDLSSKKQQSHNILD--LLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTP 366
Query: 304 ELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNIL 363
L G+ C+ +S + E+ L L
Sbjct: 367 NL---------------------HGDIFVNCF-------------LSAMVEVPAYVLAWL 392
Query: 364 GINFLGRRLSL--SITMGCTALFFLLLNICTSSAGLIGFLFMLRAL-VAANFNTVYIYTA 420
+ +L RR S+ ++ +G + L F+ L + L L M+ V A F+ VY+YTA
Sbjct: 393 LLQYLPRRYSMATALFLGGSVLLFMQL-VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTA 451
Query: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQV-----LMSASILGALCLFSSVCVVCAIS 475
E+YPT +R +G+G S + R+G++++P+ + + ++G+L + +++ +
Sbjct: 452 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPE 511
Query: 476 AFTLPI 481
+F P+
Sbjct: 512 SFGTPL 517
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 128 bits (321), Expect = 1e-29
Identities = 110/417 (26%), Positives = 188/417 (45%), Gaps = 56/417 (13%)
Query: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMV 147
L ++ G ++ +++FG LADR GR K+L++++L A +FAP++ + R +
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
Query: 148 GCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR 206
G ++G S + + E++P R + L + G L+ G+A + WR L
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---PHWRHLQL 252
Query: 207 VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--- 263
+ S P + F ESAR++ S+G L L+RVA++N KL VL
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
Query: 264 --------EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
+ + +LL LR L + ++W SFAYYG+++ DL
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL---- 360
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 374
F S Y +I ++ + L IN LGRR +
Sbjct: 361 ----------------------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQ 398
Query: 375 SITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGM 432
+ + LL + ++ + + +AA+FN +++YT E+YPT +R GM
Sbjct: 399 MAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGM 458
Query: 433 GTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPI-ETKGRAL 488
G ++ R+G++V+P +S M+A + ++ LF V A SA T+ + ET G+ L
Sbjct: 459 GMGSTMARVGSIVSPLVS---MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 128 bits (321), Expect = 1e-29
Identities = 110/417 (26%), Positives = 188/417 (45%), Gaps = 56/417 (13%)
Query: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMV 147
L ++ G ++ +++FG LADR GR K+L++++L A +FAP++ + R +
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
Query: 148 GCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR 206
G ++G S + + E++P R + L + G L+ G+A + WR L
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---PHWRHLQL 252
Query: 207 VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--- 263
+ S P + F ESAR++ S+G L L+RVA++N KL VL
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
Query: 264 --------EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
+ + +LL LR L + ++W SFAYYG+++ DL
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL---- 360
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 374
F S Y +I ++ + L IN LGRR +
Sbjct: 361 ----------------------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQ 398
Query: 375 SITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGM 432
+ + LL + ++ + + +AA+FN +++YT E+YPT +R GM
Sbjct: 399 MAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGM 458
Query: 433 GTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPI-ETKGRAL 488
G ++ R+G++V+P +S M+A + ++ LF V A SA T+ + ET G+ L
Sbjct: 459 GMGSTMARVGSIVSPLVS---MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 120 bits (300), Expect = 4e-27
Identities = 109/406 (26%), Positives = 180/406 (44%), Gaps = 43/406 (10%)
Query: 90 TTMVFF-GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVG 148
T VF G +V +++FG L DR GR +L L L T+F PS+ ++ LR V
Sbjct: 140 TQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVA 199
Query: 149 CGVSGHS-QGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRV 207
V+G S + + TE++ +R + L+Q + G +++ GLA WR L
Sbjct: 200 TAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFR---NWRLLQIT 256
Query: 208 ASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRG 267
+ PG++L F +PESAR+ ++ G A+ +++ A +NR + + + V EK G
Sbjct: 257 GTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTG 316
Query: 268 RFADLLD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVT 323
+ LD + + TL I+ +W S YYG+ L + V +T
Sbjct: 317 PSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDF-----------GLDVYLT 365
Query: 324 GGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTAL 383
G + P C S +G + L L + I F+ L + +TM
Sbjct: 366 QLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTM----- 420
Query: 384 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 443
++G + AA F Y+Y+AE++PT +R GMG G RIG
Sbjct: 421 -----------LAVVG-----KMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGG 464
Query: 444 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQ 489
++ P + + + L L ++ S+ +V + LP ET G+ L+
Sbjct: 465 ILTPLVILLGEYHAALPML-IYGSLPIVAGLLCTLLP-ETHGQGLK 508
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 119 bits (298), Expect = 6e-27
Identities = 110/427 (25%), Positives = 181/427 (42%), Gaps = 67/427 (15%)
Query: 83 NWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVF 142
+W + L + V G+ + S+ G +ADR+GR LL + L A +L + +P+Y W +
Sbjct: 146 SWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLI 205
Query: 143 LRTMVG-CGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW 201
R + G +G G I+ TEF+ +YR + QV + G L++ G+A + W
Sbjct: 206 FRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYAL---PHW 262
Query: 202 RWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEP 261
RWL ++P ++ + IPES R+ +S A+ ++ +AK N +P
Sbjct: 263 RWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLR 322
Query: 262 VLEKRGR-----FADLLDAKYLRT-TLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 315
+ E+ G+ F DL+ +R T+ + W S Y G+I+
Sbjct: 323 LEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIM--------------- 367
Query: 316 SDSAVVVTGGDSGESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRL- 372
HM D Y S + E + IL I+ +GRR
Sbjct: 368 ---------------------HMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYP 406
Query: 373 ----SLSITMGCTALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVY 423
++ C A F+ L I S G +G + + V + AE+Y
Sbjct: 407 WAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMG--------ITMAYEIVCLVNAELY 458
Query: 424 PTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIET 483
PT +R LG+ S+C IG ++ PF+ L + + L +F + +V LP ET
Sbjct: 459 PTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLP-ET 517
Query: 484 KGRALQQ 490
KG+AL +
Sbjct: 518 KGKALPE 524
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 118 bits (296), Expect = 1e-26
Identities = 100/432 (23%), Positives = 193/432 (44%), Gaps = 53/432 (12%)
Query: 78 EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
EW L +NW+V L T++ F G ++ S + G L+DR+GR +L + FS L F+
Sbjct: 131 EWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFS 190
Query: 135 PSYIWFVFLRTMVGCG-VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
S+ F L +VG G +S + I+ TE L R L + A +++ L +
Sbjct: 191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFA 250
Query: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253
I WR L+ ++PG++ + + FIPES R+ +S R A +++ AKMN +
Sbjct: 251 YFIR--DWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAV 308
Query: 254 P-----EGKLVEPVLEKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLE 307
P + + P+ +++ DL + + T+ ++W+ S Y+ + L + L
Sbjct: 309 PAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNL-- 366
Query: 308 RDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINF 367
GD+ Y +S + EI L +
Sbjct: 367 ----------------HGDA----------------YLNCFLSALIEIPAYITAWLLLRT 394
Query: 368 LGRRLSLSITM--GCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPT 425
L RR ++ + G L F+ L IG + + + + + F+ +Y++TAE+YPT
Sbjct: 395 LPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPT 454
Query: 426 TMRALGMGTSGSLCRIGAMVAPFISQV-----LMSASILGALCLFSSVCVVCAISAFTLP 480
+R + +G + + R+G+++AP+ + ++ ++G+L + + + + +
Sbjct: 455 LVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMT 514
Query: 481 IETKGRALQQIK 492
+ +Q++K
Sbjct: 515 LPETLEQMQKVK 526
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 115 bits (289), Expect = 7e-26
Identities = 101/393 (25%), Positives = 172/393 (43%), Gaps = 61/393 (15%)
Query: 78 EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
EW L N + ++ G ++ ++ G L+DR+GR IL S+L A +F+
Sbjct: 111 EWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFS 170
Query: 135 PSYIWFVFLRTMVGCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
P++ ++ R + G G+SG + +I+ E++PT+ R M + G ++ GLA
Sbjct: 171 PTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAY 230
Query: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMN-RSV 252
I WRWL SIP + ++ + PES R+ V +G + AL L RVA N +
Sbjct: 231 AIPQ---WRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKE 287
Query: 253 MPEGKLVEPVLEKRGRFADLLDAKYL-----------RTTLQIWVIWLGISFAYYGVILA 301
E +E + + L AKY R T + + W FAYY + +
Sbjct: 288 EGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMG 347
Query: 302 SAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLN 361
E F + Y II ++ +
Sbjct: 348 VEE----------------------------------FGVNLYILQIIFGGVDVPAKFIT 373
Query: 362 ILGINFLGRRLSLSITM-----GCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVY 416
IL +++LGR + + + AL F+ L++ T L F + ++++F+ ++
Sbjct: 374 ILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVF---GKGCLSSSFSCLF 430
Query: 417 IYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 449
+YT+E+YPT +R GMG S R+G+MV+P +
Sbjct: 431 LYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLV 463
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 112 bits (280), Expect = 8e-25
Identities = 112/428 (26%), Positives = 185/428 (43%), Gaps = 67/428 (15%)
Query: 82 ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFV 141
++W++ L + + G++ S+ G ADR+GR LL + L A +L +F+P+Y+ +
Sbjct: 144 DSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSML 203
Query: 142 FLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG 200
R + G G+ G + TEF+ + R + + Q+ + G + + GLA +
Sbjct: 204 LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL---PH 260
Query: 201 WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEG---- 256
WRWL S+P + ++ + +PES R+ +S A+ ++ +A+ N + P
Sbjct: 261 WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKML 320
Query: 257 KLVEPVLEKRG-RFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
L E V EK FADL LR T + +W S Y G+IL
Sbjct: 321 SLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL-------------- 366
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRL 372
HM A S Y + S + EI + ++ I+ +GR
Sbjct: 367 ----------------------HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIY 404
Query: 373 SLSIT-----MGCTALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEV 422
++++ C + F+ LNI G +G ++ + N AE+
Sbjct: 405 PMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVN--------AEL 456
Query: 423 YPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIE 482
YPT +R LG+ SLC IG ++ PFI L L LF+ + ++ A LP E
Sbjct: 457 YPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLP-E 515
Query: 483 TKGRALQQ 490
TKG AL +
Sbjct: 516 TKGVALPE 523
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 111 bits (278), Expect = 1e-24
Identities = 105/422 (24%), Positives = 179/422 (42%), Gaps = 61/422 (14%)
Query: 84 WQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFL 143
W + L ++ G++ + G ADRYGR I L+S L ++ +FAP++ FV
Sbjct: 152 WMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIF 211
Query: 144 RTMVGC-GVSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWR 202
R + G G +I TE + +K R + + Q+F+ G +++ G+A IP W+
Sbjct: 212 RFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIA-YFIP--NWQ 268
Query: 203 WLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPV 262
+ ++P + ++ + +PES R+ ++ AL L R+AK N + V
Sbjct: 269 GIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITV 328
Query: 263 LEK---RGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDS 318
++ F DL+ +R TL + W + Y G+++
Sbjct: 329 TDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM------------------ 370
Query: 319 AVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSIT- 377
+ + GG+ Y IS + E+ L +L I LGRRL + +
Sbjct: 371 RLGIIGGNL----------------YIDFFISGVVELPGALLILLTIERLGRRLPFAASN 414
Query: 378 ----MGCTALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMR 428
+ C FL L ++ G +G + F VY+ +E+YPTT+R
Sbjct: 415 IVAGVACLVTAFLPEGIAWLRTTVATLGRLG--------ITMAFEIVYLVNSELYPTTLR 466
Query: 429 ALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 488
G+ LC G ++APF+ L + + L +F + +C LP ETKG AL
Sbjct: 467 NFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLP-ETKGIAL 525
Query: 489 QQ 490
+
Sbjct: 526 PE 527
>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
Length = 742
Score = 108 bits (271), Expect = 8e-24
Identities = 83/313 (26%), Positives = 134/313 (42%), Gaps = 50/313 (15%)
Query: 35 EDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVF 94
E + G GRF L+ ++G + + +E+ ++ V P + L + ++ +V+
Sbjct: 153 EAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVY 212
Query: 95 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH 154
G MV + L+G LADR GR + LLIS + F+ +SF Y F+F R + G G+ G
Sbjct: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG- 271
Query: 155 SQGLIIK--TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG------------ 200
S ++ +EFL + RG L +FW+ G + +A IIP G
Sbjct: 272 SIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFH 331
Query: 201 -WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMN---------- 249
WR + V + P + I A PES RF + G A L++V N
Sbjct: 332 SWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERV 391
Query: 250 ------RSVMPEGKLVEPVLEKR------------------GRFADLLDAKYLRTTLQIW 285
+++ E +L+E + G F +Y R TL +
Sbjct: 392 FSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMM 451
Query: 286 VIWLGISFAYYGV 298
+W +SF+YYG+
Sbjct: 452 GVWFTMSFSYYGL 464
Score = 55.8 bits (133), Expect = 9e-08
Identities = 39/151 (25%), Positives = 70/151 (46%), Gaps = 8/151 (5%)
Query: 344 YRTMIISTIGEIALNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNICTSSAGLI 398
Y +S +G +A+ P NI+ + R L+ S M C + FFL S + +I
Sbjct: 595 YMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFG--NSESAMI 652
Query: 399 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 458
L + + A++N + + T E+YP+ R G +LC++ A++ I + +
Sbjct: 653 ALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK 712
Query: 459 LGALCLFSSVCVVCAISAFTLPIETKGRALQ 489
+ S+ + + A LP ET+G+ LQ
Sbjct: 713 AAPILFASAALALGSSLALKLP-ETRGQVLQ 742
>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
Length = 683
Score = 105 bits (261), Expect = 1e-22
Identities = 81/312 (25%), Positives = 137/312 (43%), Gaps = 48/312 (15%)
Query: 35 EDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVF 94
E ++ G GRF LF ++G + + +E+ +++ P + L + + ++ +V+
Sbjct: 96 ETIMDECGHGRFQWILFFVLGLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVY 155
Query: 95 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH 154
G M + + G LAD+ GR ++L +S A F+ L+SF Y F+F R + G G+ G
Sbjct: 156 LGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYGAFLFCRLISGIGIGGA 215
Query: 155 SQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG------------- 200
+ +EFL + RG L +FW+ G L +A IIP G
Sbjct: 216 LPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHS 275
Query: 201 WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR---------- 250
WR + V ++P + +VA KF+PES RF + G A L++V N
Sbjct: 276 WRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVF 335
Query: 251 --SVMPEGKLVEPVLEKRG-----------RFADLLD-----------AKYLRTTLQIWV 286
S + K ++ +E + RF + Y TL + V
Sbjct: 336 TVSNIKTPKQMDEFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAV 395
Query: 287 IWLGISFAYYGV 298
+W ++F+YYG+
Sbjct: 396 VWFAMAFSYYGL 407
Score = 55.8 bits (133), Expect = 9e-08
Identities = 41/165 (24%), Positives = 77/165 (46%), Gaps = 8/165 (4%)
Query: 329 ESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGR--RLSL---SITMGCTAL 383
E + C+ + +D+ ++S +G +++ P NI+ + R RL + S+ +
Sbjct: 521 EQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCC 580
Query: 384 FFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGA 443
FFL S + +IG+ + A +N + + T E+YPT RA G LC+ GA
Sbjct: 581 FFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGA 638
Query: 444 MVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 488
++ I + + + + L ++ V + A LP ET+ + L
Sbjct: 639 ILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLP-ETREQVL 682
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 104 bits (260), Expect = 2e-22
Identities = 103/430 (23%), Positives = 184/430 (42%), Gaps = 59/430 (13%)
Query: 78 EWQL---ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134
+W L W L+ + FG ++ S+ FG +DR GR +L + F + +FA
Sbjct: 143 QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFA 202
Query: 135 PSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193
Y F+ R + SG+ G + EF+ K R + F+ G+LL + L
Sbjct: 203 VDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLL-VALTG 261
Query: 194 VIIPTIGWRWLIR-VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR-- 250
++ T W WL + + S + I+ +PE+ + +S G A ++ +AK NR
Sbjct: 262 YLVRT--W-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRAS 318
Query: 251 ----SVMPEGKLVEPV------LEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIL 300
S + L PV ++K + + TL +W+IW S +Y L
Sbjct: 319 SCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSL 378
Query: 301 ASAELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPL 360
S L GG ++Y + + + EI
Sbjct: 379 NSVNL------------------GG----------------NEYLNLFLLGVVEIPAYTF 404
Query: 361 NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFML--RALVAANFNTVYIY 418
+ ++ +GRR L+ ++ C+AL ++ + ++G + + + + A F +Y+Y
Sbjct: 405 VCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLY 464
Query: 419 TAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFT 478
TAE+YPT +R+L +G+ +CR+ +++APF S L S I ++ ++ +
Sbjct: 465 TAELYPTIVRSLAVGSGSMVCRLASILAPF-SVDLSSIWIFIPQLFVGTMALLSGVLTLK 523
Query: 479 LPIETKGRAL 488
LP ET G+ L
Sbjct: 524 LP-ETLGKRL 532
>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
Length = 727
Score = 103 bits (257), Expect = 4e-22
Identities = 78/311 (25%), Positives = 134/311 (43%), Gaps = 52/311 (16%)
Query: 38 VETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVFFGY 97
++ G GRF ALF ++G + + +E+ ++ V P + + N + ++V+ G
Sbjct: 142 IQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGM 201
Query: 98 MVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQG 157
MV + +G LAD+ GR + LLI +F+ L+SF Y +F+F R + G G+ G
Sbjct: 202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPT 261
Query: 158 LI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRW 203
+ E L + RG L +FW+ G + +A IIP G WR
Sbjct: 262 VFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRV 321
Query: 204 LIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATL--------------ERVAKMN 249
+ V ++P + +VA F+PES RF + G A L E+V +N
Sbjct: 322 FVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVN 381
Query: 250 RSVMPEGKLVEPVLEKRGRFADLLDAKYLR----------------------TTLQIWVI 287
+ P K ++ ++E ++R T+++ ++
Sbjct: 382 KIKTP--KQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIV 439
Query: 288 WLGISFAYYGV 298
W +SF YYG+
Sbjct: 440 WFTLSFGYYGL 450
Score = 57.0 bits (136), Expect = 4e-08
Identities = 40/142 (28%), Positives = 70/142 (49%), Gaps = 3/142 (2%)
Query: 342 SDYRTMIISTIGEIALNPLNILG---INFLGRRLSLSITMGCTALFFLLLNICTSSAGLI 398
S Y ++ +G +A+ P NI+ ++ +GR L +M + + L TS + +I
Sbjct: 578 SAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMI 637
Query: 399 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 458
G L + L + +N++ + T E+YPT RA G G +LC+ A++ I L+S +
Sbjct: 638 GMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITK 697
Query: 459 LGALCLFSSVCVVCAISAFTLP 480
+ L S+V V + LP
Sbjct: 698 SIPILLASTVLVCGGLVGLCLP 719
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 102 bits (254), Expect = 8e-22
Identities = 90/358 (25%), Positives = 155/358 (43%), Gaps = 52/358 (14%)
Query: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMV 147
L ++ G ++ +++FG LADR GR K+L++++L A +FAP++ + R +
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
Query: 148 GCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR 206
G ++G S + + E++P R + L + G L+ G+A + WR L
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---PHWRHLQL 252
Query: 207 VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--- 263
+ S P + F ESAR++ S+G L L+RVA++N KL VL
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
Query: 264 --------EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
+ + +LL LR L + ++W SFAYYG+++ DL
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL---- 360
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 374
F S Y +I ++ + L IN LGRR +
Sbjct: 361 ----------------------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQ 398
Query: 375 SITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRAL 430
+ + LL + ++ + + +AA+FN +++YT E+YPT +RA+
Sbjct: 399 MAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 102 bits (254), Expect = 8e-22
Identities = 90/358 (25%), Positives = 155/358 (43%), Gaps = 52/358 (14%)
Query: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMV 147
L ++ G ++ +++FG LADR GR K+L++++L A +FAP++ + R +
Sbjct: 136 LAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLS 195
Query: 148 GCGVSGHSQG-LIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIR 206
G ++G S + + E++P R + L + G L+ G+A + WR L
Sbjct: 196 GMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---PHWRHLQL 252
Query: 207 VASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--- 263
+ S P + F ESAR++ S+G L L+RVA++N KL VL
Sbjct: 253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRAS 312
Query: 264 --------EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
+ + +LL LR L + ++W SFAYYG+++ DL
Sbjct: 313 LQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM--------DL---- 360
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 374
F S Y +I ++ + L IN LGRR +
Sbjct: 361 ----------------------QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQ 398
Query: 375 SITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAANFNTVYIYTAEVYPTTMRAL 430
+ + LL + ++ + + +AA+FN +++YT E+YPT +RA+
Sbjct: 399 MAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRAV 456
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 97.8 bits (242), Expect = 2e-20
Identities = 107/427 (25%), Positives = 188/427 (44%), Gaps = 60/427 (14%)
Query: 88 LVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLW----GAYFSLLTSFAPSYIWFVFL 143
L ++ G +V + +FG LADR G L+ S+L GA + +SF+ +Y F FL
Sbjct: 138 LAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS-AYCVFRFL 196
Query: 144 RTMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRW 203
M G+ +S L++ E++PT+ R L + G L++ G+A +I P WR
Sbjct: 197 MGMTFSGIILNSVSLVV--EWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRP---WRC 251
Query: 204 LIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL 263
L S P +I + ++PES+R+ + G ++ A+ L++VA MN +L + V+
Sbjct: 252 LQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVM 311
Query: 264 EK--RGRFADLLDAKYL----------RTTLQIWVIWLGISFAYYGVILASAELLERDLV 311
+ FA + + + + T + VIW S AYYG L DL
Sbjct: 312 SSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYG--------LAMDL- 362
Query: 312 CGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRR 371
K ++ + G +P A Y + + L L ++ F+
Sbjct: 363 --QKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG 420
Query: 372 LSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALG 431
+ +CT+ A L + +A++F VY++T E+YPT +R +G
Sbjct: 421 TQI---------------LCTAQAAL------GKGCLASSFICVYLFTGELYPTEIRQMG 459
Query: 432 MGTSGSLCRIGAMVAPFISQVLMSASIL-----GALCLFSSVCVVCAISAFTLP-IETKG 485
MG + R+G + AP ++ + ++IL GA + + + V +P +ET
Sbjct: 460 MGFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIA 519
Query: 486 RALQQIK 492
+++K
Sbjct: 520 AMERRVK 526
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 97.8 bits (242), Expect = 2e-20
Identities = 99/411 (24%), Positives = 176/411 (42%), Gaps = 67/411 (16%)
Query: 92 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGV 151
M G + S++F L+ D+ GR+ +L+S L F T+F S+ ++F R + V
Sbjct: 189 MFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSV 248
Query: 152 SGHS-QGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI 210
G++ + + TE+L ++R + + L F+ G++L+ G+A + W+ L V I
Sbjct: 249 VGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAVLLTGIAYSL---PHWQLLFLVGGI 305
Query: 211 PGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL-EKRGRF 269
I I +PES R+ + G + A L A +N+ +P L E L K+
Sbjct: 306 LVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIPSNLLDELQLPRKKVTR 365
Query: 270 ADLLD----AKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGG 325
A +LD + + TL + +W +S+ Y+ + L EL
Sbjct: 366 ASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMREL-------------------- 405
Query: 326 DSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFF 385
S + ++ +I E+ I + +GR+ SL++T+ ++
Sbjct: 406 --------------GVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWC 451
Query: 386 LLLNI----------------CTSSAGLIGFLFMLRAL-VAANFNTVYIYTAEVYPTTMR 428
LLL T + + MLR +AA ++YTAE+ PT +R
Sbjct: 452 LLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLR 511
Query: 429 ALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 479
A G+G GA+++ ++ + + S+L +C V AI AF+L
Sbjct: 512 ATGLGLVSLASVAGAILS--LTIISQTPSLLPIF-----LCCVLAIVAFSL 555
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 88.6 bits (218), Expect = 1e-17
Identities = 91/375 (24%), Positives = 157/375 (41%), Gaps = 66/375 (17%)
Query: 82 ENWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFV 141
++W++ L + + G++ S+ G ADR+GR LL + L A +L +F+P+Y+ +
Sbjct: 144 DSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSML 203
Query: 142 FLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG 200
R + G G+ G + TEF+ + R + + Q+ + G + + GLA +
Sbjct: 204 LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL---PH 260
Query: 201 WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEG---- 256
WRWL S+P + ++ + +PES R+ +S A+ ++ +A+ N + P
Sbjct: 261 WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKML 320
Query: 257 KLVEPVLEKRG-RFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGS 314
L E V EK FADL LR T + +W S Y G+IL
Sbjct: 321 SLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL-------------- 366
Query: 315 KSDSAVVVTGGDSGESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRL 372
HM A S Y + S + EI + ++ I+ +GR
Sbjct: 367 ----------------------HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIY 404
Query: 373 SLSIT-----MGCTALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEV 422
++++ C + F+ LNI G +G ++ + N AE+
Sbjct: 405 PMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVN--------AEL 456
Query: 423 YPTTMRALGMGTSGS 437
YPT + +G GS
Sbjct: 457 YPTFVSGVGPACRGS 471
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 79.3 bits (194), Expect = 7e-15
Identities = 97/414 (23%), Positives = 169/414 (40%), Gaps = 66/414 (15%)
Query: 96 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-H 154
G +V S ++GLL+ R+GR +L L A T FAP+++ + LR + G++G
Sbjct: 152 GILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIF 211
Query: 155 SQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII 214
L + E+ T R + + + AG + GLA + WR L AS+P
Sbjct: 212 LSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRD---WRTLQLAASVPFFA 268
Query: 215 LIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVLEKRGRFADLLD 274
+ + ++PESAR+ + G AL L +VA++N + +E ++ ++
Sbjct: 269 ISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKE--EVAS 326
Query: 275 AKYLRTTLQIW-------------VIWLGISFAYYGVILASAELLERDLVCGSKSDSAVV 321
AK R+ L ++ V+ + +YYG++ + L RD+ AV
Sbjct: 327 AKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVF-DLQSLGRDIFLLQALFGAVD 385
Query: 322 VTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCT 381
G L ++FLGRR + +
Sbjct: 386 FLG---------------------------------RATTALLLSFLGRRTIQAGSQAMA 412
Query: 382 ALFFLLLNICTSSAGLIGFLFML--RALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLC 439
L L + + +F + + + + IY AE++PT +R G ++
Sbjct: 413 GLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVG 472
Query: 440 RIGAMVAPFI-----SQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 488
R+GAM+ P I + L+ + G + + SS+ V+ F LP ET+G L
Sbjct: 473 RLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVL-----FFLP-ETQGLPL 520
>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
Length = 541
Score = 70.9 bits (172), Expect = 3e-12
Identities = 94/413 (22%), Positives = 168/413 (40%), Gaps = 46/413 (11%)
Query: 87 ALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTM 146
++V ++ G +V I+ G ++DR+GR IL L A +FAP++ + LR +
Sbjct: 146 SVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFL 205
Query: 147 VGCG----VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWR 202
G +S +S + TE++ + ++ LS G +++ GLA V W+
Sbjct: 206 AGFSSMIIISNNSLPI---TEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRD---WQ 259
Query: 203 WLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPV 262
L VAS+P + + +++ ESAR+ + T L L +VA+ N E L V
Sbjct: 260 TLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEV 319
Query: 263 LEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVV 322
+ R + LDA +TT+ DL + +
Sbjct: 320 V--RSTMQEELDAAQTKTTV-------------------------CDLFRNPSMRKRICI 352
Query: 323 TGGDSGESQSPCYCHM-----FAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSIT 377
+ P Y M + + ++ + + L +L +N +GRR+S +
Sbjct: 353 LVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILF 412
Query: 378 MGCTALFFLLLNICTSSAGLIGFLFMLRAL--VAANFNTVYIYTAEVYPTTMRALGMGTS 435
M L L + + AA F++V ++ E+ PT +RA G
Sbjct: 413 MFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGID 472
Query: 436 GSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRAL 488
+ RIGA +AP + + + + L + ++ ++ + F LP ETK L
Sbjct: 473 LTASRIGAALAPLLMTLTVFFTTLPWI-IYGIFPIIGGLIVFLLP-ETKNLPL 523
>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
Length = 553
Score = 68.2 bits (165), Expect = 2e-11
Identities = 91/402 (22%), Positives = 159/402 (39%), Gaps = 57/402 (14%)
Query: 96 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPS---YIWFVFLRTMVGCGVS 152
G +V + G +DR+GR +L S+L A +FAP+ Y F FL GV
Sbjct: 155 GILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVM 214
Query: 153 GHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPG 212
++ L++ E+ + R ++ L+ + + G L A+V W L V S+P
Sbjct: 215 MNTGTLLM--EWTAARARPLVMTLNSLGFSFGHGL---TAAVAYGVRDWTLLQLVVSVPF 269
Query: 213 IILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL--------- 263
+ + ++ ESAR+ ++TG L L RVA +N + L VL
Sbjct: 270 FLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELS 329
Query: 264 --EKRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAV 320
+ LL LR T + W F ++G+ L DL
Sbjct: 330 MGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLAL--------DL---------- 371
Query: 321 VVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGC 380
+ + + + +I +L ++ LGRR +L+ ++
Sbjct: 372 ----------------QALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLL 415
Query: 381 TALFFLLLNICTSSAGLIGFLFMLRAL--VAANFNTVYIYTAEVYPTTMRALGMGTSGSL 438
L L + G + + L V A F + IY++E++PT +R +G
Sbjct: 416 AGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMA 475
Query: 439 CRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 480
R GA++ P + + + L L ++ +V V+ ++A LP
Sbjct: 476 ARGGAILGPLVRLLGVHGPWL-PLLVYGTVPVLSGLAALLLP 516
>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
Length = 551
Score = 67.8 bits (164), Expect = 2e-11
Identities = 83/390 (21%), Positives = 158/390 (40%), Gaps = 68/390 (17%)
Query: 87 ALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTM 146
++V ++ G ++ +++G L+DR GR I + FL A + +FAP+++ + LR +
Sbjct: 146 SMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFL 205
Query: 147 VGCG---VSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRW 203
G + G++ I+ E+ + R + + + G +L+ GLA I W
Sbjct: 206 AGFSTMTILGNT--FILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAI---QDWHI 260
Query: 204 LIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL 263
L S P I+L ++ + ESAR+ + L L RVA +N E L ++
Sbjct: 261 LQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELV 320
Query: 264 EKRGRFADLLDAKYLRTTL--------------QIWVIWLGISFAYYGVILASAELLER- 308
R LDA ++T++ + + I+ +YG+IL L
Sbjct: 321 --RSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNV 378
Query: 309 ---DLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGI 365
++CG+ + +A V ++L +
Sbjct: 379 SLFQILCGAVTFTARCV--------------------------------------SLLTL 400
Query: 366 NFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRAL--VAANFNTVYIYTAEVY 423
N +GRR+S + LF L+ ++ + + V+A N+ ++ E+
Sbjct: 401 NHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELV 460
Query: 424 PTTMRALGMGTSGSLCRIGAMVAPFISQVL 453
PT +R+ G + R GA +AP + ++
Sbjct: 461 PTILRSTVAGINAVSGRTGAALAPLLMTLM 490
>gi|134053883 intestinal facilitative glucose transporter 7 [Homo
sapiens]
Length = 512
Score = 63.9 bits (154), Expect = 3e-10
Identities = 87/418 (20%), Positives = 167/418 (39%), Gaps = 39/418 (9%)
Query: 91 TMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLL---TSFAPSYIWFVFLRTMV 147
+M G ++ S+L GLL D GR LLI+ ++ ++L + A ++ VF R ++
Sbjct: 82 SMFPLGGLLGSLLVGLLVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVL 141
Query: 148 G-CGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWL 204
G C +S + E P RG + +++VF + G L I L +++ GW L
Sbjct: 142 GVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAGWPVL 201
Query: 205 IRVASIPGIILIVAFKFIPESARFN-VSTGNTRAALATLERV-AKMNRSVMPEGKLVEPV 262
+ + +P ++ ++ F PES R++ + G+ A L R+ + E E
Sbjct: 202 LALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEAR 261
Query: 263 LEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVV 322
E+ +L LR+ + W +S ++L + + L +D+
Sbjct: 262 AERAEGHLSVLHLCALRS-----LRWQLLSI----IVLMAGQQLSGINAINYYADTIYTS 312
Query: 323 TGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTA 382
G ++ SQ Y T + S + I + + + + LGRR L G
Sbjct: 313 AGVEAAHSQ------------YVT-VGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICG 359
Query: 383 LFFLLLNIC---------TSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMG 433
L+L + S G+I + + E++ + R
Sbjct: 360 SACLVLTVVLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFM 419
Query: 434 TSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIETKGRALQQI 491
G++ + + F+ + A + +F+ +C++ AI + + ETKG+ +I
Sbjct: 420 VDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIPETKGKTFVEI 477
>gi|21553331 solute carrier family 2 (facilitated glucose
transporter), member 12 [Homo sapiens]
Length = 617
Score = 63.5 bits (153), Expect = 4e-10
Identities = 70/292 (23%), Positives = 128/292 (43%), Gaps = 34/292 (11%)
Query: 37 AVETIGFGRFH------IALFLIMGS-----TGVVEAMEIMLIAVVSPVIRCEWQLENWQ 85
AVET G G H +F + S +G++ E+ +I+ I+ L +
Sbjct: 19 AVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHE 78
Query: 86 VALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRT 145
+V + + G ++ S+ G+L DRYGR +++S SL+ + SY + R
Sbjct: 79 QEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRI 138
Query: 146 MVGCGVSGHSQGLIIK-TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTI----- 199
+G +S S + E P RG ++ L+++ +++IG+ S I
Sbjct: 139 AIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNEL------MIVIGILSAYISNYAFANV 192
Query: 200 --GWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGK 257
GW+++ + G++ +A F+P S RF V G AA L R+ ++ E
Sbjct: 193 FHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALS-DTTEELT 251
Query: 258 LVEPVL--EKRGRFADLLDAK-YLRTTLQIWVIWLGISFAYYGVILASAELL 306
+++ L E + F DL +K +RT + I G++ ++ I +L
Sbjct: 252 VIKSSLKDEYQYSFWDLFRSKDNMRTRIMI-----GLTLVFFVQITGQPNIL 298
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.140 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,086,659
Number of Sequences: 37866
Number of extensions: 626480
Number of successful extensions: 1915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 1717
Number of HSP's gapped (non-prelim): 147
length of query: 492
length of database: 18,247,518
effective HSP length: 106
effective length of query: 386
effective length of database: 14,233,722
effective search space: 5494216692
effective search space used: 5494216692
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.