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Search of human proteins with 209915573
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
(714 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 1448 0.0
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 1414 0.0
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 1366 0.0
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 1164 0.0
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 1130 0.0
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 661 0.0
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 659 0.0
gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 556 e-158
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 382 e-106
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 257 2e-68
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 254 3e-67
gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapi... 72 2e-12
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 67 4e-11
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 67 4e-11
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 67 4e-11
gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sap... 67 8e-11
gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 ... 66 1e-10
gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 p... 66 1e-10
gi|73760409 tissue factor pathway inhibitor isoform b precursor ... 65 2e-10
gi|5454114 tissue factor pathway inhibitor isoform a precursor [... 65 2e-10
gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 ... 63 8e-10
gi|154759255 collagen, type XXVIII precursor [Homo sapiens] 63 8e-10
gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP... 62 1e-09
gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP... 62 1e-09
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 61 3e-09
gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sap... 61 3e-09
gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens] 59 2e-08
gi|28212222 WFIKKN2 protein [Homo sapiens] 59 2e-08
gi|145309328 papilin [Homo sapiens] 57 5e-08
gi|60498973 myelin transcription factor 1-like [Homo sapiens] 57 6e-08
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 1448 bits (3748), Expect = 0.0
Identities = 714/714 (100%), Positives = 714/714 (100%)
Query: 1 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 60
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR
Sbjct: 1 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 60
Query: 61 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 120
CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
Sbjct: 61 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 120
Query: 121 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 180
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE
Sbjct: 121 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 180
Query: 181 VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAE 240
VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAE
Sbjct: 181 VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAE 240
Query: 241 TGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEP 300
TGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEP
Sbjct: 241 TGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEP 300
Query: 301 LARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA 360
LARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
Sbjct: 301 LARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA 360
Query: 361 ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY 420
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY
Sbjct: 361 ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY 420
Query: 421 ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV 480
ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV
Sbjct: 421 ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV 480
Query: 481 IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS 540
IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
Sbjct: 481 IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS 540
Query: 541 LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS 600
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS
Sbjct: 541 LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS 600
Query: 601 GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI 660
GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI
Sbjct: 601 GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI 660
Query: 661 VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 661 VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 1414 bits (3661), Expect = 0.0
Identities = 696/696 (100%), Positives = 696/696 (100%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
Query: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258
EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG
Sbjct: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
Query: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318
KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA
Sbjct: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 374
Query: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 375 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 434
Query: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 435 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 494
Query: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 495 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 554
Query: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 555 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 614
Query: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 615 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 674
Query: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 675 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 734
Query: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 735 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 770
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 1366 bits (3536), Expect = 0.0
Identities = 676/696 (97%), Positives = 677/696 (97%), Gaps = 19/696 (2%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV
Sbjct: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 254
Query: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258
EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG
Sbjct: 255 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 314
Query: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318
KCAPFFYGGCGGNRNNFDTEEYCMAVCGSA +PTTAASTPDA
Sbjct: 315 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSA-------------------IPTTAASTPDA 355
Query: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415
Query: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475
Query: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535
Query: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595
Query: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 596 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 655
Query: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 656 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 715
Query: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 716 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 751
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 1164 bits (3011), Expect = 0.0
Identities = 601/714 (84%), Positives = 609/714 (85%), Gaps = 75/714 (10%)
Query: 1 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 60
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR
Sbjct: 1 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 60
Query: 61 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 120
CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
Sbjct: 61 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 120
Query: 121 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 180
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA
Sbjct: 121 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA- 179
Query: 181 VEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAE 240
EVEEE + E+ + + VEE E E E
Sbjct: 180 ----------------EVEEEEADDDEDDEDG------------DEVEEEAEEPYEEATE 211
Query: 241 TGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEP 300
S + TT
Sbjct: 212 R----------------------------------------------TTSIATTTTTTTE 225
Query: 301 LARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA 360
+ V++PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA
Sbjct: 226 SVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEA 285
Query: 361 ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY 420
ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY
Sbjct: 286 ERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENY 345
Query: 421 ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV 480
ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV
Sbjct: 346 ITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRV 405
Query: 481 IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS 540
IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS
Sbjct: 406 IYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPS 465
Query: 541 LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS 600
LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS
Sbjct: 466 LTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGS 525
Query: 601 GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI 660
GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI
Sbjct: 526 GLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVI 585
Query: 661 VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 586 VITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 639
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 1130 bits (2924), Expect = 0.0
Identities = 583/696 (83%), Positives = 591/696 (84%), Gaps = 75/696 (10%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK
Sbjct: 75 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 134
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD
Sbjct: 135 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 194
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA EV
Sbjct: 195 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVA-----------------EV 237
Query: 199 EEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEG 258
EEE + E+ + + VEE E E E
Sbjct: 238 EEEEADDDEDDEDG------------DEVEEEAEEPYEEATER----------------- 268
Query: 259 KCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDA 318
S + TT + V++PTTAASTPDA
Sbjct: 269 -----------------------------TTSIATTTTTTTESVEEVVRVPTTAASTPDA 299
Query: 319 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 378
VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH
Sbjct: 300 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 359
Query: 379 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 438
FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML
Sbjct: 360 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 419
Query: 439 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 498
KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV
Sbjct: 420 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 479
Query: 499 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 558
AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS
Sbjct: 480 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 539
Query: 559 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 618
LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE
Sbjct: 540 LDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAE 599
Query: 619 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 678
FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG
Sbjct: 600 FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHG 659
Query: 679 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 714
VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Sbjct: 660 VVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN 695
Score = 397 bits (1019), Expect = e-110
Identities = 213/288 (73%), Positives = 215/288 (74%), Gaps = 56/288 (19%)
Query: 1 MLPGLALLLLAAWTARALEV--------YPELQITNVV-EANQPVTIQN--WCK--RGRK 47
MLPGLALLLLAAWTARALEV E QI N + +QN W G K
Sbjct: 1 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK 60
Query: 48 QC-------------------------------------------KTHPHFVIPYRCLVG 64
C KTHPHFVIPYRCLVG
Sbjct: 61 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG 120
Query: 65 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 124
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
Sbjct: 121 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR 180
Query: 125 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 184
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
Sbjct: 181 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE 240
Query: 185 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 232
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR
Sbjct: 241 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR 288
>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
[Homo sapiens]
Length = 751
Score = 661 bits (1705), Expect = 0.0
Identities = 353/706 (50%), Positives = 467/706 (66%), Gaps = 59/706 (8%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+
Sbjct: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP +
Sbjct: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
+V + EED+ + + DY D + + A+ E+ E +E DDED+E+G+EV
Sbjct: 211 SVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDE--DDEDEEEGEEV 267
Query: 199 EEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWY 252
E+ + Y+ E T + T + + + V+ VCS++A TGPCRA++ RWY
Sbjct: 268 VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWY 327
Query: 253 FDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTA 312
FD+++GKC F YGGCGGNRNNF++E+YCMAVC + + P LPT
Sbjct: 328 FDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP--------------PTPLPT-- 371
Query: 313 ASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADK 372
+ VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA++
Sbjct: 372 ----NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAER 427
Query: 373 KAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPR 432
+ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 428 QTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPH 487
Query: 433 HVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLL 492
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLL
Sbjct: 488 RILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLL 547
Query: 493 YNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLP 552
Y VP VA+EIQ+E+DELLQ+++ A+M D S++ET V
Sbjct: 548 YKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR--- 587
Query: 553 VNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTE 608
V+ E S +++ P+H F PA ENE V + A+ + N+ +
Sbjct: 588 VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVID 644
Query: 609 EISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML 667
E +VK M G E + + ED + A+IGL+V V IATVIVI+LVML
Sbjct: 645 ETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML 704
Query: 668 KKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713
+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 705 RKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 750
>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
[Homo sapiens]
Length = 763
Score = 659 bits (1700), Expect = 0.0
Identities = 357/720 (49%), Positives = 473/720 (65%), Gaps = 75/720 (10%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+
Sbjct: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP +
Sbjct: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198
+V + EED+ + + DY D + + A+ E+ E +E DDED+E+G+EV
Sbjct: 211 SVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDE--DDEDEEEGEEV 267
Query: 199 EEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWY 252
E+ + Y+ E T + T + + + V+ VCS++A TGPCRA++ RWY
Sbjct: 268 VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWY 327
Query: 253 FDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTA 312
FD+++GKC F YGGCGGNRNNF++E+YCMAVC + + P LPT
Sbjct: 328 FDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP--------------PTPLPT-- 371
Query: 313 ASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADK 372
+ VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA++
Sbjct: 372 ----NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAER 427
Query: 373 KAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPR 432
+ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP
Sbjct: 428 QTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPH 487
Query: 433 HVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLL 492
+ L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLL
Sbjct: 488 RILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLL 547
Query: 493 YNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLP 552
Y VP VA+EIQ+E+DELLQ+++ A+M D S++ET V
Sbjct: 548 YKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR--- 587
Query: 553 VNGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI- 610
V+ E S +++ P+H F PA ENE +P P GL + + I
Sbjct: 588 VSSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVIN 644
Query: 611 SEVKMDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGG 653
S+ K+D D +V ++++F AE VG + A+IGL+V
Sbjct: 645 SKNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIA 702
Query: 654 VVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713
V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 703 VAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762
>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
[Homo sapiens]
Length = 695
Score = 556 bits (1432), Expect = e-158
Identities = 325/701 (46%), Positives = 423/701 (60%), Gaps = 105/701 (14%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+
Sbjct: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
Query: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138
F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP
Sbjct: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCP------ 204
Query: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVV-EVAEEEEVAEVEEEEADDDEDDEDGDE 197
+ K++ V++EEE + EEEE +D+E+D D +
Sbjct: 205 ---------------------------QTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYK 237
Query: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257
E E E+ TE E EEVV + +Y+D +
Sbjct: 238 SEFPTEADLEDFTEAAVD---EDDEDEEEGEEVVED---------------RDYYYDTFK 279
Query: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD 317
G D E GS + S + T + VK+P T T D
Sbjct: 280 GD----------------DYNEENPTEPGSDGTMSDKEITHD------VKVPPTPLPTND 317
Query: 318 AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQ 377
VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQ
Sbjct: 318 -VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQ 376
Query: 378 HFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNM 437
HFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP +
Sbjct: 377 HFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQA 436
Query: 438 LKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA 497
L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP
Sbjct: 437 LRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPY 496
Query: 498 VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEF 557
VA+EIQ+E+DELLQ+++ A+M D S++ET V V+ E
Sbjct: 497 VAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSEE 536
Query: 558 SLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEV 613
S +++ P+H F PA ENE V + A+ + N+ +E +V
Sbjct: 537 S-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV 593
Query: 614 K-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQY 672
K M G E + + ED + A+IGL+V V IATVIVI+LVML+K+QY
Sbjct: 594 KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQY 653
Query: 673 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713
+I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 654 GTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
[Homo sapiens]
Length = 522
Score = 382 bits (981), Expect = e-106
Identities = 215/411 (52%), Positives = 278/411 (67%), Gaps = 29/411 (7%)
Query: 308 LPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 367
+P T T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNL
Sbjct: 135 VPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNL 193
Query: 368 PKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAV 427
PKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+
Sbjct: 194 PKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSD 253
Query: 428 PPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQ 487
PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQ
Sbjct: 254 PPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQ 313
Query: 488 SLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTT 547
SLSLLY VP VA+EIQ+E+DELLQ+++ A+M D S++ET
Sbjct: 314 SLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVD 356
Query: 548 VELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLT 603
V V+ E S +++ P+H F PA ENE V + A+ +
Sbjct: 357 VR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDE 410
Query: 604 NIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVI 662
N+ +E +VK M G E + + ED + A+IGL+V V IATVIVI
Sbjct: 411 NMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVI 470
Query: 663 TLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713
+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 471 SLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 521
Score = 68.2 bits (165), Expect = 3e-11
Identities = 30/45 (66%), Positives = 38/45 (84%), Gaps = 2/45 (4%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLV 63
E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLV
Sbjct: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKS--RFVTPFKCLV 135
>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
[Homo sapiens]
Length = 651
Score = 257 bits (657), Expect = 2e-68
Identities = 157/401 (39%), Positives = 234/401 (58%), Gaps = 49/401 (12%)
Query: 317 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 376
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
Query: 377 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 436
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
Query: 437 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 496
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
Query: 497 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 556
+A+E++ ++ ELL E L PS E P G
Sbjct: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
Query: 557 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 614
S D LQP S AD+ + E A P ++ + E E K
Sbjct: 503 SSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK------------MNPLEQYERK 550
Query: 615 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 670
++A G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 551 VNASV--PRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 608
Query: 671 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 711
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 609 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649
Score = 160 bits (406), Expect = 3e-39
Identities = 132/414 (31%), Positives = 190/414 (45%), Gaps = 53/414 (12%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77
++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C
Sbjct: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
Query: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137
+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP
Sbjct: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
Query: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197
D S A D S W GS VE AE+EE E + DD + E
Sbjct: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
Query: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257
EEE P T T T T+ V+ G RA + D+ E
Sbjct: 265 EEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKM-----DLEE 319
Query: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---QSLLKTTQEPLARDP 305
+ + N E+ MA S A++ QS+L+T +E ++ +
Sbjct: 320 RRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER 369
Query: 306 VKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAK 365
+L T A+ A+ E A Q + ER+ +R + AE++
Sbjct: 370 QRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVLLALRRYLRAEQK-- 422
Query: 366 NLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 419
+++ ++H+Q V +++ E A + + V TH+ +E +N L +N
Sbjct: 423 -----EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQN 470
>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
[Homo sapiens]
Length = 650
Score = 254 bits (648), Expect = 3e-67
Identities = 153/401 (38%), Positives = 229/401 (57%), Gaps = 50/401 (12%)
Query: 317 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 376
D VD Y PG+ +EH F +AK LE + ++++VMREW A+ Q+KNLPKAD++A+
Sbjct: 292 DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALN 351
Query: 377 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 436
+HFQ +++LE++ + ERQ+LVETH RV A++ND+RR ALE ++ ALQA PP+ V
Sbjct: 352 EHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLL 411
Query: 437 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 496
L++Y+RAEQK+++HTL+H++HV VDP+KA Q+R QV THL+VI ER+NQSL LL P
Sbjct: 412 ALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNP 471
Query: 497 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 556
+A+E++ ++ ELL E L PS E P G
Sbjct: 472 HLAQELRPQIQELLHSEH----------------------LGPSELEA-------PAPGG 502
Query: 557 FSLD--DLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVK 614
S D LQP S D P +G T + + K + + +
Sbjct: 503 SSEDKGGLQPPDS--KDDTPM-------------TLPKGSTEQDAASPEKEKMNPLEQYE 547
Query: 615 MDAEFRHDSGYEVHH---QKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVML-KKK 670
G+ H Q+ G ++ A+ GL++ G ++IV+++++L +KK
Sbjct: 548 RKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKK 607
Query: 671 QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQ 711
Y +I HGVVEVD +T EE+ L ++Q++GYENPTY+F E+
Sbjct: 608 PYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648
Score = 160 bits (406), Expect = 3e-39
Identities = 132/414 (31%), Positives = 190/414 (45%), Gaps = 53/414 (12%)
Query: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHF-VIPYRCLVGEFVSDALLVPDKC 77
++YPELQI V +A Q + ++ WC R HPH V+P+RCL GEFVS+ALLVP+ C
Sbjct: 97 QMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGC 156
Query: 78 KFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEES 137
+FLHQERMD CE+ H A+E CS + LH GMLLPCG D+FRGVE+VCCP
Sbjct: 157 RFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTP 216
Query: 138 DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDE 197
D S A D S W GS VE AE+EE E + DD + E
Sbjct: 217 D--PSGTAVGDPSTRSW-------PPGSR---VEGAEDEEEEESFPQPVDDYFVEPPQAE 264
Query: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257
EEE P T T T T+ V+ G RA + D+ E
Sbjct: 265 EEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKM-----DLEE 319
Query: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGS---------AMS---QSLLKTTQEPLARDP 305
+ + N E+ MA S A++ QS+L+T +E ++ +
Sbjct: 320 RRM----------RQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGER 369
Query: 306 VKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAK 365
+L T A+ A+ E A Q + ER+ +R + AE++
Sbjct: 370 QRLVETHATRVIALINDQRRAALEGFLAALQ-----ADPPQAERVLLALRRYLRAEQK-- 422
Query: 366 NLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 419
+++ ++H+Q V +++ E A + + V TH+ +E +N L +N
Sbjct: 423 -----EQRHTLRHYQH-VAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQN 470
>gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo
sapiens]
Length = 252
Score = 72.0 bits (175), Expect = 2e-12
Identities = 39/103 (37%), Positives = 48/103 (46%), Gaps = 16/103 (15%)
Query: 199 EEEAEEPYEEATERTTS-IATTTTTTTESVEEVVR---------------EVCSEQAETG 242
+EE + TE T +AT+ SV R E C+ A TG
Sbjct: 81 KEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG 140
Query: 243 PCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
PCRA RWYFDV C F YGGC GN+N++ +EE CM C
Sbjct: 141 PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRC 183
Score = 64.3 bits (155), Expect = 4e-10
Identities = 25/60 (41%), Positives = 36/60 (60%)
Query: 228 EEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS 287
E + + C G CRA + RW+++VT+G C F YGGC GN NN+ T+E C+ C +
Sbjct: 31 ERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCAT 90
>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
sapiens]
Length = 2971
Score = 67.4 bits (163), Expect = 4e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 200 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 259
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2871 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2930
Query: 260 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 291
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 2931 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 2962
>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
sapiens]
Length = 3177
Score = 67.4 bits (163), Expect = 4e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 200 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 259
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 3077 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 3136
Query: 260 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 291
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 3137 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 3168
>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
sapiens]
Length = 2570
Score = 67.4 bits (163), Expect = 4e-11
Identities = 27/92 (29%), Positives = 47/92 (51%)
Query: 200 EEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK 259
++++ P + +S +TE + ++C + G CR I +WY+D
Sbjct: 2470 KKSQPPPPQPARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKS 2529
Query: 260 CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 291
CA F+YGGCGGN N F +++ C VC +++
Sbjct: 2530 CARFWYGGCGGNENKFGSQKECEKVCAPVLAK 2561
>gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo
sapiens]
Length = 89
Score = 66.6 bits (161), Expect = 8e-11
Identities = 25/61 (40%), Positives = 40/61 (65%)
Query: 225 ESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAV 284
+++++++ VC+ E GPC+ ++RW+F+ G+C F YGGCGGN NNF +E C
Sbjct: 26 DTIKDLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKF 85
Query: 285 C 285
C
Sbjct: 86 C 86
>gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 66.2 bits (160), Expect = 1e-10
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 214 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 273
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 274 NFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDEN 330
N+ EE C+ C S+ + + P+ + S +D +LE N
Sbjct: 289 NYLREEECILACRGVQGPSMER--RHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPN 343
Score = 60.5 bits (145), Expect = 5e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 294
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 434
Query: 295 KTTQEPLARDPVKLPTTAA 313
+E + +P+T +
Sbjct: 435 GLRRE------IPIPSTGS 447
>gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2
precursor [Homo sapiens]
Length = 513
Score = 66.2 bits (160), Expect = 1e-10
Identities = 36/117 (30%), Positives = 52/117 (44%), Gaps = 6/117 (5%)
Query: 214 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 273
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 274 NFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDEN 330
N+ EE C+ C S+ + + P+ + S +D +LE N
Sbjct: 289 NYLREEECILACRGVQGPSMER--RHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPN 343
Score = 60.5 bits (145), Expect = 5e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 294
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 375 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 434
Query: 295 KTTQEPLARDPVKLPTTAA 313
+E + +P+T +
Sbjct: 435 GLRRE------IPIPSTGS 447
>gi|73760409 tissue factor pathway inhibitor isoform b precursor
[Homo sapiens]
Length = 251
Score = 65.5 bits (158), Expect = 2e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 218 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 277
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 278 EEYCMAVCGSAMSQSLLKTT 297
E C +C + ++KTT
Sbjct: 97 LEECKKMCTRDNANRIIKTT 116
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 195 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 254
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 255 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|5454114 tissue factor pathway inhibitor isoform a precursor
[Homo sapiens]
Length = 304
Score = 65.5 bits (158), Expect = 2e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 218 TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDT 277
T T T +++ C+ +A+ GPC+A++ R++F++ +C F YGGC GN+N F++
Sbjct: 37 TIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFES 96
Query: 278 EEYCMAVCGSAMSQSLLKTT 297
E C +C + ++KTT
Sbjct: 97 LEECKKMCTRDNANRIIKTT 116
Score = 62.8 bits (151), Expect = 1e-09
Identities = 26/61 (42%), Positives = 36/61 (59%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 294
C A+ G CRA +R+Y++ GKC PF Y GCGGN NNF +++ C+ C Q +
Sbjct: 217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRIS 276
Query: 295 K 295
K
Sbjct: 277 K 277
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 195 GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFD 254
G E + E EE + T T ++++ + C + + G CR I+R++++
Sbjct: 86 GCEGNQNRFESLEECKKMCTRDNANRIIKT-TLQQEKPDFCFLEEDPGICRGYITRYFYN 144
Query: 255 VTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
+C F YGGC GN NNF+T E C +C
Sbjct: 145 NQTKQCERFKYGGCLGNMNNFETLEECKNIC 175
>gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1
precursor [Homo sapiens]
Length = 529
Score = 63.2 bits (152), Expect = 8e-10
Identities = 29/72 (40%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 214 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRN 273
T+ T T +T+ E+ C + G CR RWY+D TE C F YGGC GN+N
Sbjct: 233 TANVTVTVLSTKQTEDY----CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN 288
Query: 274 NFDTEEYCMAVC 285
N+ EE C+ C
Sbjct: 289 NYLREEECILAC 300
Score = 60.5 bits (145), Expect = 5e-09
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 6/79 (7%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 294
C + +TG C+ I RWY++ CA F YGGC GN+NNF+ E+ C+ C + +
Sbjct: 391 CVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVF 450
Query: 295 KTTQEPLARDPVKLPTTAA 313
+E + +P+T +
Sbjct: 451 GLRRE------IPIPSTGS 463
>gi|154759255 collagen, type XXVIII precursor [Homo sapiens]
Length = 1125
Score = 63.2 bits (152), Expect = 8e-10
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 4/111 (3%)
Query: 175 EEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREV 234
++E++E D DEDD+ + + + P ++E TT+ +T + E+
Sbjct: 1016 QKEISESLSVTRDQDEDDKAPEPTWAD-DLPATTSSEATTTPRPLLSTPVDGAED---PR 1071
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
C E + G C + RWY+D CA F++ GC G+ N F++E+ C C
Sbjct: 1072 CLEALKPGNCGEYVVRWYYDKQVNSCARFWFSGCNGSGNRFNSEKECQETC 1122
>gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 2 [Homo sapiens]
Length = 117
Score = 62.4 bits (150), Expect = 1e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 229 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 55 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 111
>gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP
domains 1 isoform 1 precursor [Homo sapiens]
Length = 133
Score = 62.4 bits (150), Expect = 1e-09
Identities = 23/57 (40%), Positives = 34/57 (59%)
Query: 229 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
++ ++VC ETGPC A W++D + C+ F YGGC GN NNF ++ C+ C
Sbjct: 71 DLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTC 127
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/118 (34%), Positives = 48/118 (40%), Gaps = 20/118 (16%)
Query: 178 VAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSE 237
V+ EEEE EDDE + E EE Y++ S + CS
Sbjct: 2836 VSHAEEEERVPPEDDEYSEYSEYSVEE-YQDPEAPWDS----------------DDPCSL 2878
Query: 238 QAETGPCRAMISRWYFDVTEGK---CAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQS 292
+ G C A RWY G C PF YGGCGGN N F T E C C + QS
Sbjct: 2879 PLDEGSCTAYTLRWYHRAVTGSTEACHPFVYGGCGGNANRFGTREACERRCPPRVVQS 2936
>gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo
sapiens]
Length = 352
Score = 61.2 bits (147), Expect = 3e-09
Identities = 26/52 (50%), Positives = 30/52 (57%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG 286
C+ GPCRA I W FD +GKC F YGGC GN N F +E+ C CG
Sbjct: 287 CNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYCG 338
Score = 57.8 bits (138), Expect = 3e-08
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 14/103 (13%)
Query: 205 PYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFF 264
P EE + T T +S C GPC M SR++++ T C F
Sbjct: 209 PQEEEGSGGGQLVTEVTKKEDS--------CQLGYSAGPCMGMTSRYFYNGTSMACETFQ 260
Query: 265 YGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVK 307
YGGC GN NNF TE+ C+ C + + +L P+ R P +
Sbjct: 261 YGGCMGNGNNFVTEKECLQTCRTVAACNL------PIVRGPCR 297
>gi|5730091 tissue factor pathway inhibitor 2 [Homo sapiens]
Length = 235
Score = 58.9 bits (141), Expect = 2e-08
Identities = 25/53 (47%), Positives = 31/53 (58%)
Query: 233 EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
E+C + GPCRA++ R+Y+D C F YGGC GN NNF T E C C
Sbjct: 34 EICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDAC 86
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/57 (38%), Positives = 30/57 (52%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQ 291
C + G C A ++R+YF+ C F Y GCGGN NNF + E C C A+ +
Sbjct: 158 CYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKK 214
Score = 39.7 bits (91), Expect = 0.010
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 3/60 (5%)
Query: 229 EVVREVCSEQAETGP-CRAMISRWYFDVTEGKCAPFFYGGCGGNR--NNFDTEEYCMAVC 285
E V +VC Q C +++F+++ C FF GGC NR N F E CM C
Sbjct: 90 EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFC 149
>gi|28212222 WFIKKN2 protein [Homo sapiens]
Length = 576
Score = 58.5 bits (140), Expect = 2e-08
Identities = 24/51 (47%), Positives = 30/51 (58%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC 285
CS A GPC+A RW ++ G+C F YGGC GN NNF++ E C C
Sbjct: 386 CSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436
Score = 45.8 bits (107), Expect = 1e-04
Identities = 19/53 (35%), Positives = 27/53 (50%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS 287
C + ++ C +RW+FD C F +G C N N+F+T E CM C S
Sbjct: 328 CLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMS 380
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 57.4 bits (137), Expect = 5e-08
Identities = 23/55 (41%), Positives = 33/55 (60%)
Query: 235 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAM 289
C + G C +RWYF + G+C F+YGGC GN NNF +E+ CM+ C ++
Sbjct: 727 CLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQGSL 781
>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
Length = 1184
Score = 57.0 bits (136), Expect = 6e-08
Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 135 EESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDED 194
++SD + D +E+D + D D G ED+ E + EE E+EEE+ DDDED ED
Sbjct: 91 DDSDGTEDMDEKEEDEGEEYS-EDND-EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGED 148
Query: 195 GDEVEEEAEEPYEEATE 211
++ EEE EE EE E
Sbjct: 149 VEDEEEEEEEEEEEEEE 165
Score = 41.2 bits (95), Expect = 0.003
Identities = 50/213 (23%), Positives = 79/213 (37%), Gaps = 36/213 (16%)
Query: 131 CPLAEESDNVDSADAEE-----------DDSDVWWGGADTDYADGSEDKVVEVAEEEEVA 179
CPLA++ D E D S V + D +DG+ED ++ EE+E
Sbjct: 55 CPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSV----DECDDSDGTED--MDEKEEDEGE 108
Query: 180 EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 239
E E+ + ++DE+ +E + E EE EE E E EE E E+
Sbjct: 109 EYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEEN 168
Query: 240 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQE 299
E +R D + + NN + + Y +++SLL +
Sbjct: 169 EDHQMNCHNTRIMQDTEK------------DDNNNDEYDNY-----DELVAKSLLNLGK- 210
Query: 300 PLARDPVKLPTTAASTPDAVDKYLETPGDENEH 332
+A D T + LE D+NE+
Sbjct: 211 -IAEDAAYRARTESEMNSNTSNSLEDDSDKNEN 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,263,357
Number of Sequences: 37866
Number of extensions: 1284598
Number of successful extensions: 20574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 470
Number of HSP's successfully gapped in prelim test: 400
Number of HSP's that attempted gapping in prelim test: 9497
Number of HSP's gapped (non-prelim): 5700
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.