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Search of human proteins with 209862778
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
(542 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 1116 0.0
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 1077 0.0
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 983 0.0
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 983 0.0
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 983 0.0
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 897 0.0
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 884 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 370 e-102
gi|4503787 fyn-related kinase [Homo sapiens] 370 e-102
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 368 e-102
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 367 e-101
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 363 e-100
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 363 e-100
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 363 e-100
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 359 3e-99
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 359 3e-99
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 358 5e-99
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 358 5e-99
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 357 2e-98
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 348 7e-96
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 347 2e-95
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 344 1e-94
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 332 5e-91
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 331 1e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens] 322 5e-88
gi|187475373 c-src tyrosine kinase [Homo sapiens] 316 3e-86
gi|4758078 c-src tyrosine kinase [Homo sapiens] 316 3e-86
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 305 7e-83
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 9e-83
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 294 1e-79
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 1116 bits (2887), Expect = 0.0
Identities = 542/542 (100%), Positives = 542/542 (100%)
Query: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHEALHRPYG 60
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHEALHRPYG
Sbjct: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHEALHRPYG 60
Query: 61 CDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQ 120
CDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQ
Sbjct: 61 CDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQ 120
Query: 121 NGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESE 180
NGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESE
Sbjct: 121 NGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESE 180
Query: 181 SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHY 240
SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHY
Sbjct: 181 SSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHY 240
Query: 241 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 300
PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE
Sbjct: 241 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 300
Query: 301 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEV 360
DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEV
Sbjct: 301 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEV 360
Query: 361 TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA 420
TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA
Sbjct: 361 TAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTA 420
Query: 421 HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKG 480
HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKG
Sbjct: 421 HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKG 480
Query: 481 YRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEVLLHCANQTCI 540
YRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEVLLHCANQTCI
Sbjct: 481 YRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEVLLHCANQTCI 540
Query: 541 TL 542
TL
Sbjct: 541 TL 542
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 1077 bits (2784), Expect = 0.0
Identities = 529/550 (96%), Positives = 529/550 (96%), Gaps = 21/550 (3%)
Query: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH-------- 52
MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH
Sbjct: 1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE 60
Query: 53 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 99
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
Sbjct: 61 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA 120
Query: 100 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 159
SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
Sbjct: 121 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR 180
Query: 160 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 219
SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
Sbjct: 181 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST 240
Query: 220 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 279
LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
Sbjct: 241 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG 300
Query: 280 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 339
EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
Sbjct: 301 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV 360
Query: 340 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 399
TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
Sbjct: 361 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 420
Query: 400 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 459
HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
Sbjct: 421 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT 480
Query: 460 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 519
YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
Sbjct: 481 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540
Query: 520 TMFHDSSISE 529
TMFHDSSISE
Sbjct: 541 TMFHDSSISE 550
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 983 bits (2542), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 53 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 112
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 59 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 118
Query: 113 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 172
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 119 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 178
Query: 173 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 232
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 179 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 238
Query: 233 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 292
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 239 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 298
Query: 293 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 352
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 299 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 358
Query: 353 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 412
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 359 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 418
Query: 413 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 472
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 419 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 478
Query: 473 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
Sbjct: 479 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 535
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 983 bits (2542), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 53 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 112
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 59 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 118
Query: 113 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 172
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 119 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 178
Query: 173 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 232
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 179 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 238
Query: 233 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 292
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 239 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 298
Query: 293 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 352
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 299 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 358
Query: 353 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 412
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 359 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 418
Query: 413 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 472
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 419 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 478
Query: 473 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
Sbjct: 479 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 535
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 983 bits (2542), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 53 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 112
EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK
Sbjct: 38 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEK 97
Query: 113 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 172
LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING
Sbjct: 98 LRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLING 157
Query: 173 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 232
SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD
Sbjct: 158 SFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD 217
Query: 233 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 292
GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT
Sbjct: 218 GLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT 277
Query: 293 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 352
VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL
Sbjct: 278 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL 337
Query: 353 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 412
RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
Sbjct: 338 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL 397
Query: 413 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 472
MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
Sbjct: 398 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 457
Query: 473 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE
Sbjct: 458 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 514
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 897 bits (2317), Expect = 0.0
Identities = 443/531 (83%), Positives = 475/531 (89%), Gaps = 10/531 (1%)
Query: 1 MGQQVGRV-GEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHEALHRPY 59
MGQQ G+V G+ P I+G+ + S R P N+F +HEAL RP
Sbjct: 1 MGQQPGKVLGDQRRPSLPALHFIKGAGK-KESSRHGGPH-------CNVFVEHEALQRPV 52
Query: 60 GCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGY 118
D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGEKLRVLGY
Sbjct: 53 ASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGY 112
Query: 119 NQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE 178
N NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS INGSFLVRE
Sbjct: 113 NHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRE 172
Query: 179 SESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTL 238
SESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVADGL+TTL
Sbjct: 173 SESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTL 232
Query: 239 HYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTL 298
HYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSLTVAVKTL
Sbjct: 233 HYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 292
Query: 299 KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNRE 358
KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDYLRECNR+
Sbjct: 293 KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQ 352
Query: 359 EVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTY 418
EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSRLMTGDTY
Sbjct: 353 EVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTY 412
Query: 419 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE 478
TAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY+LLE
Sbjct: 413 TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 472
Query: 479 KGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
K YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+
Sbjct: 473 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 523
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 884 bits (2283), Expect = 0.0
Identities = 427/478 (89%), Positives = 452/478 (94%), Gaps = 1/478 (0%)
Query: 53 EALHRPYGCDVEPQALNEAIRWSSKENLL-GATESDPNLFVALYDFVASGDNTLSITKGE 111
EAL RP D EPQ L+EA RW+SKENLL G +E+DPNLFVALYDFVASGDNTLSITKGE
Sbjct: 27 EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGE 86
Query: 112 KLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN 171
KLRVLGYN NGEW E ++KNGQGWVPSNYITPVNSLEKHSWYHGPVSR+AAEYLLSS IN
Sbjct: 87 KLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN 146
Query: 172 GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVA 231
GSFLVRESESSPGQ SISLRYEGRVYHYRINT +DGK+YV++ESRF+TLAELVHHHSTVA
Sbjct: 147 GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVA 206
Query: 232 DGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSL 291
DGL+TTLHYPAPK NKPTVYGVSP +DKWEMERTDITMKHKLGGGQYGEVY GVWKKYSL
Sbjct: 207 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266
Query: 292 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDY 351
TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT EPPFYI+TE+M YGNLLDY
Sbjct: 267 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDY 326
Query: 352 LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 411
LRECNR+EV AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH+VKVADFGLSR
Sbjct: 327 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 386
Query: 412 LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 471
LMTGDTYTAHAGAKFPIKWTAPESLAYN FSIKSDVWAFGVLLWEIATYGMSPYPGIDLS
Sbjct: 387 LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 446
Query: 472 QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISE 529
QVY+LLEK YRME+PEGCP KVYELMRACW+W+P+DRPSFAE HQAFETMF +SSIS+
Sbjct: 447 QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 504
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 370 bits (951), Expect = e-102
Identities = 199/442 (45%), Positives = 277/442 (62%), Gaps = 15/442 (3%)
Query: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
I +G Y+T ++F TL +LV H+S ADGL L A C P G++ D W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT-PQTSGLAK--DAW 261
Query: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
E+ R + ++ KLG G + EV++G W + VA+KTLK TM E FL+EA +MK++KH
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKH 320
Query: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E
Sbjct: 321 DKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 379
Query: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 380 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 439
Query: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
Query: 501 WKWSPADRPSFAETHQAFETMF 522
WK P +RP+F E F
Sbjct: 500 WKKDPEERPTFEYLQSFLEDYF 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 370 bits (949), Expect = e-102
Identities = 198/454 (43%), Positives = 273/454 (60%), Gaps = 16/454 (3%)
Query: 91 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW--------SEVRSKNGQGWVPSNYIT 142
FVAL+D+ A LS G+KL+VL G W + S+ QG++PSNY+
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 143 PVNSLEKHSWYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 200
SL+ W+ G + RS AE L S GSFL+RESES G+ S+S+ V HYR
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYR 166
Query: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 259
I +G ++T FSTL E V H++ +DGL L P K P + +S D+
Sbjct: 167 IKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQ 226
Query: 260 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 319
WE++R I + +LG GQ+GEV+ G+W + VAVKTLK +M+ +FL+EA +MK ++
Sbjct: 227 WEIDRNSIQLLKRLGSGQFGEVWEGLWNN-TTPVAVKTLKPGSMDPNDFLREAQIMKNLR 285
Query: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379
HP L+QL VCTLE P YI+TE M +G+L +YL+ ++ + MA Q++S M YL
Sbjct: 286 HPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYL 345
Query: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM---TGDTYTAHAGAKFPIKWTAPESL 436
E +N+IHRDLAARN LVGE+++ KVADFGL+R+ D Y + K P+KWTAPE++
Sbjct: 346 ESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAI 405
Query: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYEL 496
N FSIKSDVW+FG+LL+EI TYG PY G+ +QV +L + YR+ QP CP + Y +
Sbjct: 406 RSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465
Query: 497 MRACWKWSPADRPSFAETHQAFETMFH-DSSISE 529
M CW P +RP+F E F DSS S+
Sbjct: 466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 368 bits (945), Expect = e-102
Identities = 199/443 (44%), Positives = 277/443 (62%), Gaps = 14/443 (3%)
Query: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
+ WY G + R AE L S N G+FL+RESE++ G S+S+R V HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204
Query: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVS-PIHDK 259
I +G Y+T ++F TL +LV H+S A GL L P K P + +S D
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-GMPRLTDLSVKTKDV 263
Query: 260 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 319
WE+ R + + +LG GQ+GEV++G W + VA+KTLK TM E FL+EA +MK++K
Sbjct: 264 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLK 322
Query: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379
H LVQL V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+
Sbjct: 323 HDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
Query: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 439
E+ N+IHRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 382 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441
Query: 440 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 499
F+IKSDVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
Query: 500 CWKWSPADRPSFAETHQAFETMF 522
CWK P +RP+F E F
Sbjct: 502 CWKKDPEERPTFEYLQSFLEDYF 524
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 367 bits (943), Expect = e-101
Identities = 200/442 (45%), Positives = 275/442 (62%), Gaps = 15/442 (3%)
Query: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
Query: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
Query: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
Query: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
Query: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
Query: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
Query: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
Query: 501 WKWSPADRPSFAETHQAFETMF 522
WK P +RP+F E F
Sbjct: 509 WKKDPDERPTFEYIQSFLEDYF 530
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 363 bits (933), Expect = e-100
Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)
Query: 56 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 115
H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK +
Sbjct: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
Query: 116 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 171
L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
Query: 172 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226
G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
Query: 227 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 286
+ V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
Query: 287 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 346
S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
Query: 347 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 406
+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
Query: 407 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 466
FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
Query: 467 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 522
G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 363 bits (933), Expect = e-100
Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)
Query: 56 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 115
H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK +
Sbjct: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
Query: 116 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 171
L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
Query: 172 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226
G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
Query: 227 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 286
+ V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
Query: 287 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 346
S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
Query: 347 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 406
+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
Query: 407 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 466
FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
Query: 467 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 522
G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 363 bits (933), Expect = e-100
Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)
Query: 56 HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 115
H P + QA+N S + G + LF+ALYD+ A ++ L+ TKGEK +
Sbjct: 49 HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
Query: 116 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 171
L N G+W E RS + G +PSNY+ PV+S++ WY G + R AE L S N
Sbjct: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
Query: 172 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226
G+FL+RESE++ G S+S+R V HY+I G Y+T +F+++ ELV H
Sbjct: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
Query: 227 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 286
+ V DGL L P KP G++ D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
Query: 287 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 346
S VAVKTLK TM + FL+EA VMK ++H LVQL V + E P YIVTE+M +G
Sbjct: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
Query: 347 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 406
+LLD+L+ +++ L+ MA Q++ M Y+E+ N+IHRDL A N LVGE K+AD
Sbjct: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
Query: 407 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 466
FGL+RL+ D Y G+KFPIKWTAPE+ + F+IKSDVW+FG+LL E+ T G PYP
Sbjct: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
Query: 467 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 522
G++ +V + +E+GY M P GCP +YE M W+ P +RP+F E F
Sbjct: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 3e-99
Identities = 215/523 (41%), Positives = 307/523 (58%), Gaps = 34/523 (6%)
Query: 24 GSSAARP---SGRRR--DPAGRTTETGFNIFTQHEALHRPYGCD--------VEPQALNE 70
GS+ ++P S RRR +PA G F + +P D P A
Sbjct: 2 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
Query: 71 AI--RWSSKENLLGATESDP-----NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGE 123
+ ++S + + + P FVALYD+ + + LS KGE+L+++ +
Sbjct: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 124 WSEVRSKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESE 180
W GQ G++PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 181 SSPGQLSISL----RYEG-RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV 235
++ G +S+ +G V HY+I G Y+T+ ++F++L +LV ++S ADGL
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 236 TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 295
L P +KP G++ D WE+ R + ++ KLG G +GEV++G W + VA+
Sbjct: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
Query: 296 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 355
KTLK TM E FL+EA VMK+++H LVQL V + E P YIVTEYM G+LLD+L+
Sbjct: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE 356
Query: 356 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 415
+ + L+ MA QI+S M Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+
Sbjct: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
Query: 416 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 475
+ YTA GAKFPIKWTAPE+ Y F+IKSDVW+FG+LL E+ T G PYPG+ +V D
Sbjct: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
Query: 476 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 518
+E+GYRM P CP +++LM CW+ P +RP+F E QAF
Sbjct: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF-EYLQAF 518
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 359 bits (922), Expect = 3e-99
Identities = 215/523 (41%), Positives = 307/523 (58%), Gaps = 34/523 (6%)
Query: 24 GSSAARP---SGRRR--DPAGRTTETGFNIFTQHEALHRPYGCD--------VEPQALNE 70
GS+ ++P S RRR +PA G F + +P D P A
Sbjct: 2 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
Query: 71 AI--RWSSKENLLGATESDP-----NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGE 123
+ ++S + + + P FVALYD+ + + LS KGE+L+++ +
Sbjct: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
Query: 124 WSEVRSKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESE 180
W GQ G++PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE
Sbjct: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
Query: 181 SSPGQLSISL----RYEG-RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV 235
++ G +S+ +G V HY+I G Y+T+ ++F++L +LV ++S ADGL
Sbjct: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
Query: 236 TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 295
L P +KP G++ D WE+ R + ++ KLG G +GEV++G W + VA+
Sbjct: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
Query: 296 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 355
KTLK TM E FL+EA VMK+++H LVQL V + E P YIVTEYM G+LLD+L+
Sbjct: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE 356
Query: 356 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 415
+ + L+ MA QI+S M Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+
Sbjct: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
Query: 416 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 475
+ YTA GAKFPIKWTAPE+ Y F+IKSDVW+FG+LL E+ T G PYPG+ +V D
Sbjct: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
Query: 476 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 518
+E+GYRM P CP +++LM CW+ P +RP+F E QAF
Sbjct: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF-EYLQAF 518
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 83 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 140
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 194
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 195 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 251
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 252 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 311
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 312 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 371
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 372 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 431
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 432 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 491
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 492 KVYELMRACWKWSPADRPSFAETHQAFETMF 522
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 83 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 140
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
Query: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 194
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
Query: 195 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 251
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
Query: 252 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 311
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
Query: 312 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 371
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
Query: 372 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 431
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
Query: 432 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 491
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
Query: 492 KVYELMRACWKWSPADRPSFAETHQAFETMF 522
++Y+LMR CWK P DRP+F E F
Sbjct: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 357 bits (916), Expect = 2e-98
Identities = 207/485 (42%), Positives = 296/485 (61%), Gaps = 27/485 (5%)
Query: 43 ETGFNIFTQHEALHRPYGCDV---EPQALNEAIRWSSKENLLGATE--SDPNLFVALYDF 97
+ G N F++ E P+ C V +P + + S N G E S+ + VALYD+
Sbjct: 31 QVGGNTFSKTETSASPH-CPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDY 89
Query: 98 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHG 155
A LS KG+++ VL ++GEW + RS +G++PSNY+ V+SLE W+
Sbjct: 90 EAIHHEDLSFQKGDQMVVL--EESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFK 147
Query: 156 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-YEGR----VYHYRINTTADGK 208
+SR AE L + N GSF++R+SE++ G S+S+R Y+ R V HY+I T +G
Sbjct: 148 GISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG 207
Query: 209 VYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTD 266
Y++ S FSTL ELV H+ DGL L P + K KP D WE+ R
Sbjct: 208 FYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE------KDAWEIPRES 261
Query: 267 ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL 326
+ ++ KLG GQ+GEV++ + K++ VAVKT+K +M VE FL EA VMK ++H LV+L
Sbjct: 262 LKLEKKLGAGQFGEVWMATYNKHT-KVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKL 320
Query: 327 LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH 386
V T EP YI+TE+M G+LLD+L+ + L+ + QI+ M ++E++N+IH
Sbjct: 321 HAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379
Query: 387 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 446
RDL A N LV + V K+ADFGL+R++ + YTA GAKFPIKWTAPE++ + +F+IKSD
Sbjct: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439
Query: 447 VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA 506
VW+FG+LL EI TYG PYPG+ +V LE+GYRM +PE CP ++Y +M CWK P
Sbjct: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499
Query: 507 DRPSF 511
+RP+F
Sbjct: 500 ERPTF 504
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 348 bits (893), Expect = 7e-96
Identities = 190/463 (41%), Positives = 281/463 (60%), Gaps = 20/463 (4%)
Query: 60 GCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYN 119
G D++ Q + E+ + E ++ VALY + + LS KGEK++VL
Sbjct: 16 GVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--E 73
Query: 120 QNGEWSEVRS--KNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFL 175
++GEW + +S +G++PSNY+ +N+LE W+ ++R AE L + N G+FL
Sbjct: 74 EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFL 133
Query: 176 VRESESSPGQLSISLRYEGRVY-----HYRINTTADGKVYVTAESRFSTLAELVHHHSTV 230
+RESE+ G S+S+R V+ HY+I + +G Y++ F +++++ H+
Sbjct: 134 IRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 193
Query: 231 ADGLVTTLHYP--APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKK 288
ADGL L +PK KP D WE+ R I + +LG GQ+GEV++G +
Sbjct: 194 ADGLCRRLEKACISPKPQKPWD------KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN 247
Query: 289 YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 348
S VAVKTLK TM V+ FL+EA +MK ++H LV+L V T E P YI+TEYM G+L
Sbjct: 248 -STKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 306
Query: 349 LDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFG 408
LD+L+ +V L+ + QI+ M Y+E+KN+IHRDL A N LV E+ + K+ADFG
Sbjct: 307 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFG 366
Query: 409 LSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGI 468
L+R++ + YTA GAKFPIKWTAPE++ + F+IKSDVW+FG+LL+EI TYG PYPG
Sbjct: 367 LARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 426
Query: 469 DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 511
+ V L +GYRM + E CP ++Y++M+ CWK +RP+F
Sbjct: 427 TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 469
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 347 bits (890), Expect = 2e-95
Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)
Query: 85 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 142
E ++ VALY + + LS KGEK++VL ++GEW + +S +G++PSNY+
Sbjct: 62 EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
Query: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 197
+N+LE W+ ++R AE L + N G+FL+RESE+ G S+S+R V+
Sbjct: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
Query: 198 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 253
HY+I + +G Y++ F +++++ H+ ADGL L +PK KP
Sbjct: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
Query: 254 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 313
D WE+ R I + +LG GQ+GEV++G + S VAVKTLK TM V+ FL+EA
Sbjct: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
Query: 314 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 373
+MK ++H LV+L V T E P YI+TEYM G+LLD+L+ +V L+ + QI+
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
Query: 374 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 433
M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++ + YTA GAKFPIKWTAP
Sbjct: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
Query: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493
E++ + F+IKSDVW+FG+LL+EI TYG PYPG + V L +GYRM + E CP ++
Sbjct: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
Query: 494 YELMRACWKWSPADRPSF 511
Y++M+ CWK +RP+F
Sbjct: 473 YDIMKMCWKEKAEERPTF 490
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 344 bits (883), Expect = 1e-94
Identities = 195/447 (43%), Positives = 270/447 (60%), Gaps = 18/447 (4%)
Query: 85 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 142
+ D + VALYD+ A D L + KGEKL+VL G+W RS +G+VPSN++
Sbjct: 57 DEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL--KGTGDWWLARSLVTGREGYVPSNFVA 114
Query: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR---YEGR-V 196
V SLE W+ R AE L + IN GSFL+RESE++ G S+S++ +G +
Sbjct: 115 RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELI 174
Query: 197 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI 256
HY+I +G Y++ F +L LV H+S DGL L P C +P
Sbjct: 175 KHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---CVRPAPQNPWA- 230
Query: 257 HDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMK 316
D+WE+ R + + KLG GQ+GEV++G +K ++ VA+KTLKE TM E FL EA VMK
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMK 289
Query: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376
++H LV+L V T EP YIVTEYM G LLD+L+ ++ L+ M+ QI+ M
Sbjct: 290 ALQHERLVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGM 348
Query: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 436
Y+E+ N IHRDL A N LV E K+ADFGL+R++ + YTA GAKFPIKWTAPE++
Sbjct: 349 AYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE-YTAQEGAKFPIKWTAPEAI 407
Query: 437 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE- 495
+ F+IK+DVW+FGVLL E+ TYG PYPG+ +V LE+GYRM +P+ CPP++Y
Sbjct: 408 HFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRG 467
Query: 496 LMRACWKWSPADRPSFAETHQAFETMF 522
++ CW+ P +RP+F E +
Sbjct: 468 VIAECWRSRPEERPTFEFLQSVLEDFY 494
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 332 bits (851), Expect = 5e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 85 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 142
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
Query: 143 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 194
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
Query: 195 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 250
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
Query: 251 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 310
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
Query: 311 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 370
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
Query: 371 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 430
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
Query: 431 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 490
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
Query: 491 PKVYELMRACWKWSPADRPSFAE 513
VYE+M CW+ P RPSF +
Sbjct: 592 NYVYEVMLRCWQEKPEGRPSFED 614
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 331 bits (848), Expect = 1e-90
Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)
Query: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 149
VALYD++ N L + KG++ +L N W R KNGQ G++PSNY+T +S+E
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
Query: 150 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 202
+ WY ++RS AE LL G F+VR+S S G+ ++S+ +G + HY +
Sbjct: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
Query: 203 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 260
+T + Y+ + FST+ EL+++H + GL++ L YP + NK P+ G+ + W
Sbjct: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
Query: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
E++ D+T +LG GQ+G V G W+ VA+K +KE +M +EF++EA VM + H
Sbjct: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
Query: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
LVQL GVCT + P +I+TEYM G LL+YLRE R LL M + AMEYLE
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
Query: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
K F+HRDLAARNCLV + VVKV+DFGLSR + D YT+ G+KFP++W+ PE L Y+
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
Query: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
FS KSD+WAFGVL+WEI + G PY S+ + + +G R+ +P KVY +M +C
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
Query: 501 WKWSPADRPSF 511
W +RP+F
Sbjct: 634 WHEKADERPTF 644
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 322 bits (825), Expect = 5e-88
Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)
Query: 93 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 149
ALYDF+ L++ + E+ +L N W + R + G +G +PSNY+T + +LE
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
Query: 150 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 202
+ WYH ++R+ AE+LL G+F+VR+S G +IS+ E + HY+I
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
Query: 203 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 260
G+ YV F ++ EL+ +H A GL+T L YP P G S ++KW
Sbjct: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
Query: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
E++ +++ ++G GQ+G V++G W+ + + VA+K + E +M E+F++EA VM ++ H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
Query: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
LVQL GVC P YIVTE+M G LL+YLRE N+ ++ +LL + I MEYLE
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
Query: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
+ +IHRDLAARNCLV +VK++DFG++R + D Y + GAKFPIKW+ PE +N
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
Query: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
+S KSDVW+FGVL+WE+ T G P+ QV + + +G+R+ +P P +YE+M +C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
Query: 501 WKWSPADRPSFAETHQA 517
W P RP+FAE +A
Sbjct: 503 WHEKPEGRPTFAELLRA 519
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 3e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 150
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 151 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 205 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 263
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 264 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 323
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 324 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 382
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 383 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 442
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 443 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 502
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 503 WSPADRPSFAETHQAFE 519
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 316 bits (810), Expect = 3e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 150
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 151 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
Query: 205 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 263
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
Query: 264 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 323
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
Query: 324 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 382
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
Query: 383 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 442
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
Query: 443 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 502
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
Query: 503 WSPADRPSFAETHQAFE 519
A RPSF + + E
Sbjct: 425 LDAAMRPSFLQLREQLE 441
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 305 bits (781), Expect = 7e-83
Identities = 173/432 (40%), Positives = 247/432 (57%), Gaps = 17/432 (3%)
Query: 88 PNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ---GWVPSNYITPV 144
P LF+ALYDF A LS+ +G++L L + G + R +GQ G VP ++
Sbjct: 53 PQLFLALYDFTARCGGELSVRRGDRLCAL--EEGGGYIFARRLSGQPSAGLVPITHVAKA 110
Query: 145 N--SLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYR 200
+ +L WY VSR+ A+ LL S N G+FL+R SESS G S+S+R + +V HYR
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
++ ADG +Y+ F L EL+ ++ + L +P + +P D W
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL-------QPCMPQKAPRQDVW 223
Query: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
E ++ + KLG G +GEV+ G+W SL VA+K +K M++ + KE +K ++H
Sbjct: 224 ERPHSEFALGRKLGEGYFGEVWEGLWLG-SLPVAIKVIKSANMKLTDLAKEIQTLKGLRH 282
Query: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
L++L VC+ P YIVTE M GNL +L + LL A Q++ M YLE
Sbjct: 283 ERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLE 342
Query: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
++ +HRDLAARN LV + KVADFGL+RL+ D Y+ + +K P+KWTAPE+ Y
Sbjct: 343 EQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV 402
Query: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
FS KSDVW+FGVLL E+ TYG PY G+ + + +GYR+ +P CP +VY LM C
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLEC 462
Query: 501 WKWSPADRPSFA 512
W+ SP +RPSFA
Sbjct: 463 WRSSPEERPSFA 474
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 305 bits (780), Expect = 9e-83
Identities = 174/471 (36%), Positives = 271/471 (57%), Gaps = 24/471 (5%)
Query: 60 GC---DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVL 116
GC D A + + + ++N E + + +ALYD+ + L++ + E+ +L
Sbjct: 142 GCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLL 201
Query: 117 GYNQNGEWSEVRSKNG-QGWVPSNYITPV--NSLEKHSWYHGPVSRSAAE-YLLSSLING 172
++ W V+ +NG +G+VPS+Y+ N+LE + WY+ +SR AE LL + G
Sbjct: 202 DSSEI-HWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEG 260
Query: 173 SFLVRESESSPGQLSISLRYEGRVY-------HYRINTTADG--KVYVTAESRFSTLAEL 223
+F+VR+S ++ G ++S+ + V HY I T D + YV + F ++ L
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319
Query: 224 VHHHSTVADGLVTTLHYPA--PKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEV 281
+++H GLVT L YP + P G+ + KW ++ +++T ++G GQ+G V
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLR--YGKWVIDPSELTFVQEIGSGQFGLV 377
Query: 282 YVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 341
++G W VA+KT++E M E+F++EA VM ++ HP LVQL GVC + P +V E
Sbjct: 378 HLGYWLNKD-KVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFE 436
Query: 342 YMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHV 401
+M +G L DYLR R A LL M + M YLE+ IHRDLAARNCLVGEN V
Sbjct: 437 FMEHGCLSDYLRT-QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQV 495
Query: 402 VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYG 461
+KV+DFG++R + D YT+ G KFP+KW +PE +++ +S KSDVW+FGVL+WE+ + G
Sbjct: 496 IKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG 555
Query: 462 MSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 512
PY S+V + + G+R+ +P VY++M CWK P DRP+F+
Sbjct: 556 KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFS 606
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 294 bits (753), Expect = 1e-79
Identities = 176/437 (40%), Positives = 242/437 (55%), Gaps = 57/437 (13%)
Query: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
LFVALYD+ A ++ LS KGEK ++L ++ G+W E RS G++PSNY+ PV+S+
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSE-GDWWEARSLTTGETGYIPSNYVAPVDSI 144
Query: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
+ WY G + R AE L S N G+FL+RESE++ G Y I
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKG-----------AYSLSIRDWD 193
Query: 206 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERT 265
D K D + HY K + Y I + + E
Sbjct: 194 DMK----------------------GDHVK---HYKIRKLDNGGYY----ITTRAQFETL 224
Query: 266 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 325
++H Y G W + VA+KTLK TM E FL+EA +MK++KH LVQ
Sbjct: 225 QQLVQH----------YSGTWNG-NTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 273
Query: 326 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 385
L V + E P YIVTEYM G+LLD+L++ + L+ MA Q+++ M Y+E+ N+I
Sbjct: 274 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 332
Query: 386 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKS 445
HRDL + N LVG + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+IKS
Sbjct: 333 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 392
Query: 446 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 505
DVW+FG+LL E+ T G PYPG++ +V + +E+GYRM P+ CP ++ELM CWK P
Sbjct: 393 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 452
Query: 506 ADRPSFAETHQAFETMF 522
+RP+F E F
Sbjct: 453 EERPTFEYLQSFLEDYF 469
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,087,965
Number of Sequences: 37866
Number of extensions: 1017410
Number of successful extensions: 5331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 756
Number of HSP's successfully gapped in prelim test: 223
Number of HSP's that attempted gapping in prelim test: 2727
Number of HSP's gapped (non-prelim): 1232
length of query: 542
length of database: 18,247,518
effective HSP length: 107
effective length of query: 435
effective length of database: 14,195,856
effective search space: 6175197360
effective search space used: 6175197360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.