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Search of human proteins with 207448705
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
(1013 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 2030 0.0
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 222 2e-57
gi|206725526 signal-induced proliferation-associated protein 1 [... 220 5e-57
gi|206725523 signal-induced proliferation-associated protein 1 [... 220 5e-57
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 219 1e-56
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 218 2e-56
gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 217 5e-56
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 211 4e-54
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 211 4e-54
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 211 4e-54
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 84 7e-16
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 84 7e-16
gi|118600961 akt substrate AS250 [Homo sapiens] 77 6e-14
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 67 1e-10
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 67 1e-10
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 67 1e-10
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 52 3e-06
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 52 3e-06
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 52 3e-06
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 52 3e-06
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 52 3e-06
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 52 3e-06
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 52 3e-06
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 52 3e-06
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 50 1e-05
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 50 1e-05
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 50 1e-05
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 50 1e-05
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 46 2e-04
>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
Length = 1013
Score = 2030 bits (5259), Expect = 0.0
Identities = 1013/1013 (100%), Positives = 1013/1013 (100%)
Query: 1 MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQR 60
MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQR
Sbjct: 1 MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQR 60
Query: 61 AGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSP 120
AGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSP
Sbjct: 61 AGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSP 120
Query: 121 FFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPR 180
FFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPR
Sbjct: 121 FFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPR 180
Query: 181 EIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDT 240
EIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDT
Sbjct: 181 EIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDT 240
Query: 241 ITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGN 300
ITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGN
Sbjct: 241 ITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGN 300
Query: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLP 360
DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLP
Sbjct: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLP 360
Query: 361 TPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNML 420
TPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNML
Sbjct: 361 TPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNML 420
Query: 421 NRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGICKKEPWE 480
NRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGICKKEPWE
Sbjct: 421 NRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGICKKEPWE 480
Query: 481 PQCFCSNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQMHVLETLDL 540
PQCFCSNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQMHVLETLDL
Sbjct: 481 PQCFCSNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQMHVLETLDL 540
Query: 541 LVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRE 600
LVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRE
Sbjct: 541 LVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRE 600
Query: 601 LRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVD 660
LRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVD
Sbjct: 601 LRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVD 660
Query: 661 GPAEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYN 720
GPAEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYN
Sbjct: 661 GPAEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYN 720
Query: 721 YSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGN 780
YSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGN
Sbjct: 721 YSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGN 780
Query: 781 LVHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSL 840
LVHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSL
Sbjct: 781 LVHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSL 840
Query: 841 GEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRM 900
GEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRM
Sbjct: 841 GEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRM 900
Query: 901 EIKEIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPS 960
EIKEIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPS
Sbjct: 901 EIKEIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPS 960
Query: 961 GSLESASTSEANPEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK 1013
GSLESASTSEANPEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK
Sbjct: 961 GSLESASTSEANPEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK 1013
>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
[Homo sapiens]
Length = 715
Score = 222 bits (565), Expect = 2e-57
Identities = 128/319 (40%), Positives = 186/319 (58%), Gaps = 9/319 (2%)
Query: 97 RWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYS 156
R Y ++FLG+ H N+ + LSV + + R IL K T +P +
Sbjct: 140 RAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEEAEG--IEYLRVILRSKLKTVHERIPLA 197
Query: 157 PTKTL-SVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQL 215
L SV I A D + +P+ + ++ +E E + FKFGV++ K Q
Sbjct: 198 GLSKLPSVPQIAKAFCDDAVGLRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQT 257
Query: 216 TDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIM 275
++E+F N S F++FL+LLGDTITL+ + G+RGGLD + TG+ SVYT ++ EIM
Sbjct: 258 LEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIM 317
Query: 276 FHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRY 335
FHVST LP++ + QQ++RKRHIGNDIV I+FQ EE++P F P MI S+F H + +V+
Sbjct: 318 FHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQ--EENTP-FVPDMIASNFLHAYIVVQV 374
Query: 336 ---NQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTF 392
+ +Y++ + + E VP FGPPLP+PPVF EFR+FLL KL N E A ++ F
Sbjct: 375 ETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKF 434
Query: 393 AQKRRRTLDMLIRSLHQDL 411
A+ RT L+ +LH +L
Sbjct: 435 AKLEDRTRAALLDNLHDEL 453
>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
[Homo sapiens]
Length = 730
Score = 222 bits (565), Expect = 2e-57
Identities = 128/319 (40%), Positives = 186/319 (58%), Gaps = 9/319 (2%)
Query: 97 RWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYS 156
R Y ++FLG+ H N+ + LSV + + R IL K T +P +
Sbjct: 155 RAYRRHFLGKDHLNFYCTGSSLGNLILSVKCEEAEG--IEYLRVILRSKLKTVHERIPLA 212
Query: 157 PTKTL-SVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQL 215
L SV I A D + +P+ + ++ +E E + FKFGV++ K Q
Sbjct: 213 GLSKLPSVPQIAKAFCDDAVGLRFNPVLYPKASQMIVSYDEHEVNNTFKFGVIYQKARQT 272
Query: 216 TDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIM 275
++E+F N S F++FL+LLGDTITL+ + G+RGGLD + TG+ SVYT ++ EIM
Sbjct: 273 LEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIM 332
Query: 276 FHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRY 335
FHVST LP++ + QQ++RKRHIGNDIV I+FQ EE++P F P MI S+F H + +V+
Sbjct: 333 FHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQ--EENTP-FVPDMIASNFLHAYIVVQV 389
Query: 336 ---NQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTF 392
+ +Y++ + + E VP FGPPLP+PPVF EFR+FLL KL N E A ++ F
Sbjct: 390 ETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREFLLTKLTNAENACCKSDKF 449
Query: 393 AQKRRRTLDMLIRSLHQDL 411
A+ RT L+ +LH +L
Sbjct: 450 AKLEDRTRAALLDNLHDEL 468
>gi|206725526 signal-induced proliferation-associated protein 1
[Homo sapiens]
Length = 1042
Score = 220 bits (561), Expect = 5e-57
Identities = 134/340 (39%), Positives = 187/340 (55%), Gaps = 18/340 (5%)
Query: 83 RRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQ---RVPQYR 139
R + LE+ + +Y KYF G+ HQN+ G D P +S+ ++ + YR
Sbjct: 203 RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYR 262
Query: 140 AILWRKTGTQKI-------CLPYSPTKTLSVKSILSAMNLDKFEKGPR-EIFHPEIQKDL 191
I+ R T + + LP P + LS + +L + R P++ + L
Sbjct: 263 VIV-RTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTL 321
Query: 192 LVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRG 251
L L+EQ S K G+L+ + GQ +++EM++N+ F +FL LLGD + LKG+ YR
Sbjct: 322 LTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRA 381
Query: 252 GLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGE 311
LDTK D+TG HS+YT YQ HEIMFHVSTMLPY+ N+QQ+ RKRHIGNDIVTIVFQ E
Sbjct: 382 QLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQ--E 439
Query: 312 ESSPAFKPSMIRSHFTHIFALVRYN---QQNDNYRLKIFSEESVPLFGPPLPT-PPVFTD 367
S F P+ IRSHF H+F +VR + + YR+ + + P FGP LP F
Sbjct: 440 PGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAA 499
Query: 368 HQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSL 407
+ +FR FLL K +NGE+A F RT ++ L
Sbjct: 500 NADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
Score = 30.8 bits (68), Expect = 6.7
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 2/88 (2%)
Query: 909 TRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAST 968
T ++LL L + G G P ++ R SQ P + S + +P+ + +
Sbjct: 803 TTKQLLHLCLQDGGSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861
Query: 969 SEANPEGHSASSDQDPVADREGSPVSGS 996
+ A P SA S+ DR GSP SGS
Sbjct: 862 TTAKPSVPSADSETPLTQDRPGSP-SGS 888
>gi|206725523 signal-induced proliferation-associated protein 1
[Homo sapiens]
Length = 1042
Score = 220 bits (561), Expect = 5e-57
Identities = 134/340 (39%), Positives = 187/340 (55%), Gaps = 18/340 (5%)
Query: 83 RRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQ---RVPQYR 139
R + LE+ + +Y KYF G+ HQN+ G D P +S+ ++ + YR
Sbjct: 203 RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYR 262
Query: 140 AILWRKTGTQKI-------CLPYSPTKTLSVKSILSAMNLDKFEKGPR-EIFHPEIQKDL 191
I+ R T + + LP P + LS + +L + R P++ + L
Sbjct: 263 VIV-RTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTL 321
Query: 192 LVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRG 251
L L+EQ S K G+L+ + GQ +++EM++N+ F +FL LLGD + LKG+ YR
Sbjct: 322 LTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRA 381
Query: 252 GLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGE 311
LDTK D+TG HS+YT YQ HEIMFHVSTMLPY+ N+QQ+ RKRHIGNDIVTIVFQ E
Sbjct: 382 QLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQ--E 439
Query: 312 ESSPAFKPSMIRSHFTHIFALVRYN---QQNDNYRLKIFSEESVPLFGPPLPT-PPVFTD 367
S F P+ IRSHF H+F +VR + + YR+ + + P FGP LP F
Sbjct: 440 PGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAA 499
Query: 368 HQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSL 407
+ +FR FLL K +NGE+A F RT ++ L
Sbjct: 500 NADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDL 539
Score = 30.8 bits (68), Expect = 6.7
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 2/88 (2%)
Query: 909 TRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAST 968
T ++LL L + G G P ++ R SQ P + S + +P+ + +
Sbjct: 803 TTKQLLHLCLQDGGSPPG-PGDLAEERTEFLHSQNSLSPRSSLSDEAPVLPNTTPDLLLA 861
Query: 969 SEANPEGHSASSDQDPVADREGSPVSGS 996
+ A P SA S+ DR GSP SGS
Sbjct: 862 TTAKPSVPSADSETPLTQDRPGSP-SGS 888
>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
sapiens]
Length = 1781
Score = 219 bits (557), Expect = 1e-56
Identities = 128/343 (37%), Positives = 195/343 (56%), Gaps = 26/343 (7%)
Query: 89 LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLS--DQNNQRVPQYR-AILWRK 145
+E+ + R+Y YF+G+ H NY G D + P +S+ + + + PQY+ I++R
Sbjct: 494 IEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRT 553
Query: 146 ----TGTQKICLPYSPTKTL-----------SVKSILSAMNLDKFEKGPREIFHPEIQKD 190
T I +PT T +++ ++ +N+ + P++ +
Sbjct: 554 RELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLA---LNTPKVTEQ 610
Query: 191 LLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYR 250
LL L+EQ K G+L+ K GQ +++EM++NE F++FL+L+G+ + LKG+T Y
Sbjct: 611 LLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYA 670
Query: 251 GGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEG 310
LD K D+TG HS+YT+YQ +EIMFHVST+LPY+ N+QQ+ RKRHIGNDIVTI+FQ
Sbjct: 671 AQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQ-- 728
Query: 311 EESSPAFKPSMIRSHFTHIFALVR-YNQQNDN--YRLKIFSEESVPLFGPPLPTPPVFTD 367
E + F P IRSHF H+F +VR +N DN Y + + + P FGPP+P+ F
Sbjct: 729 EPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRK 788
Query: 368 HQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQD 410
FRDFLL K+IN E A ++ F RT ++ L ++
Sbjct: 789 SDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAEN 831
>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
sapiens]
Length = 1804
Score = 218 bits (556), Expect = 2e-56
Identities = 138/375 (36%), Positives = 206/375 (54%), Gaps = 30/375 (8%)
Query: 89 LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRV---PQYRAILWRK 145
+E+ + +Y K+F + H NY G D P +S+ + + P I++R
Sbjct: 482 VEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRT 541
Query: 146 TGTQKI-------CLP----YSPTKTLSVKSILSAMNLDKFEKGPREIFH-PEIQKDLLV 193
+ + +P +S + L +K +L + + + R F+ P++ + L+
Sbjct: 542 SELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMK 601
Query: 194 LEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGL 253
L+EQ + K G+++ K GQ T++EM++NE F++FL LLG+ + LKG+ YR L
Sbjct: 602 LDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQL 661
Query: 254 DTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEES 313
DTK D+TG HS+YT Y+ +EIMFHVSTMLPY+ NKQQ+ RKRHIGNDIVTIVFQ E
Sbjct: 662 DTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQ--EPG 719
Query: 314 SPAFKPSMIRSHFTHIFALVR-YNQQNDN--YRLKIFSEESVPLFGPPLPTPPVFTDHQE 370
+ F P IRSHF H+F +VR +N +D+ Y + + VP FGPP+P F
Sbjct: 720 AQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNV 779
Query: 371 FRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDL-HKNMLNRR-SFSDV 428
FRDFLL K+IN E A ++ F RT Q+ + DL KN+ N S
Sbjct: 780 FRDFLLAKVINAENAAHKSEKFRAMATRT--------RQEYLKDLAEKNVTNTPIDPSGK 831
Query: 429 LPESPKSARKKEEAR 443
P +++KKE+++
Sbjct: 832 FPFISLASKKKEKSK 846
>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
sapiens]
Length = 1722
Score = 217 bits (552), Expect = 5e-56
Identities = 136/376 (36%), Positives = 202/376 (53%), Gaps = 31/376 (8%)
Query: 89 LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTL----------SDQNNQRVPQY 138
+E+ + +Y K+F G+ HQNY G D P +S+ Q N RV
Sbjct: 477 IEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFR 536
Query: 139 RAILWRKTGT-QKICLP----YSPTKTLSVKSILSAMNLDKFEKGPREIFH-PEIQKDLL 192
+ L G + +P + + L +K +L + + + R+ + P++ + LL
Sbjct: 537 TSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLL 596
Query: 193 VLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGG 252
L+EQ S K G+L+ K GQ T++EM++NE F++FL+LLG + LKG++ YR
Sbjct: 597 KLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQ 656
Query: 253 LDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEE 312
LD K D+TG HS+YT Y+ +E+MFHVST+LPY N+QQ+ RKRHIGNDIVTIVFQ E
Sbjct: 657 LDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQ--EP 714
Query: 313 SSPAFKPSMIRSHFTHIFALVRYNQ---QNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQ 369
+ F P IRSHF H+F +V+ + +N Y + + + VP FGPP+P F
Sbjct: 715 GALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSA 774
Query: 370 EFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVL 429
FRDFLL K+IN E A ++ F RT Q+ + DL +N + + +
Sbjct: 775 VFRDFLLAKVINAENAAHKSEKFRAMATRT--------RQEYLKDLAENFVTTATVDTSV 826
Query: 430 PES--PKSARKKEEAR 443
S A+KKE+ +
Sbjct: 827 KFSFITLGAKKKEKVK 842
>gi|224809582 RAP1 GTPase activating protein isoform c [Homo
sapiens]
Length = 663
Score = 211 bits (536), Expect = 4e-54
Identities = 129/336 (38%), Positives = 188/336 (55%), Gaps = 20/336 (5%)
Query: 85 TDVHLE-NPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILW 143
T V LE NP R Y K+FLG+ H NY DA S+ +Q R +L
Sbjct: 77 TKVKLECNPT--ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQE--HLRLLLR 132
Query: 144 RKTGTQKICLPYS-----PTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQE 198
K T +P S P K + +N+D+F + +P+ + ++ +E
Sbjct: 133 TKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYP----VLYPKASRLIVTFDEHV 188
Query: 199 GSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKND 258
S NFKFGV++ K GQ +++E+FS S F +FL LG + L+ + G+RGGLD +
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248
Query: 259 TTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFK 318
TG SVY ++ EIMFHVST LPY++ + QQ++RKRHIGNDIV +VFQ +E++P F
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQ--DENTP-FV 305
Query: 319 PSMIRSHFTHIFALVRYNQQNDN---YRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFL 375
P MI S+F H + +V+ + Y++ + + + VP FGPPLP P VF EF++FL
Sbjct: 306 PDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFL 365
Query: 376 LVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDL 411
L KLIN E A + FA+ RT L+ +L+++L
Sbjct: 366 LTKLINAEYACYKAEKFAKLEERTRAALLETLYEEL 401
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo
sapiens]
Length = 727
Score = 211 bits (536), Expect = 4e-54
Identities = 129/336 (38%), Positives = 188/336 (55%), Gaps = 20/336 (5%)
Query: 85 TDVHLE-NPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILW 143
T V LE NP R Y K+FLG+ H NY DA S+ +Q R +L
Sbjct: 141 TKVKLECNPT--ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQE--HLRLLLR 196
Query: 144 RKTGTQKICLPYS-----PTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQE 198
K T +P S P K + +N+D+F + +P+ + ++ +E
Sbjct: 197 TKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYP----VLYPKASRLIVTFDEHV 252
Query: 199 GSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKND 258
S NFKFGV++ K GQ +++E+FS S F +FL LG + L+ + G+RGGLD +
Sbjct: 253 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 312
Query: 259 TTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFK 318
TG SVY ++ EIMFHVST LPY++ + QQ++RKRHIGNDIV +VFQ +E++P F
Sbjct: 313 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQ--DENTP-FV 369
Query: 319 PSMIRSHFTHIFALVRYNQQNDN---YRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFL 375
P MI S+F H + +V+ + Y++ + + + VP FGPPLP P VF EF++FL
Sbjct: 370 PDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFL 429
Query: 376 LVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDL 411
L KLIN E A + FA+ RT L+ +L+++L
Sbjct: 430 LTKLINAEYACYKAEKFAKLEERTRAALLETLYEEL 465
>gi|224809573 RAP1 GTPase activating protein isoform b [Homo
sapiens]
Length = 681
Score = 211 bits (536), Expect = 4e-54
Identities = 129/336 (38%), Positives = 188/336 (55%), Gaps = 20/336 (5%)
Query: 85 TDVHLE-NPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILW 143
T V LE NP R Y K+FLG+ H NY DA S+ +Q R +L
Sbjct: 77 TKVKLECNPT--ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQE--HLRLLLR 132
Query: 144 RKTGTQKICLPYS-----PTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQE 198
K T +P S P K + +N+D+F + +P+ + ++ +E
Sbjct: 133 TKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYP----VLYPKASRLIVTFDEHV 188
Query: 199 GSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKND 258
S NFKFGV++ K GQ +++E+FS S F +FL LG + L+ + G+RGGLD +
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248
Query: 259 TTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFK 318
TG SVY ++ EIMFHVST LPY++ + QQ++RKRHIGNDIV +VFQ +E++P F
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQ--DENTP-FV 305
Query: 319 PSMIRSHFTHIFALVRYNQQNDN---YRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFL 375
P MI S+F H + +V+ + Y++ + + + VP FGPPLP P VF EF++FL
Sbjct: 306 PDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFL 365
Query: 376 LVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDL 411
L KLIN E A + FA+ RT L+ +L+++L
Sbjct: 366 LTKLINAEYACYKAEKFAKLEERTRAALLETLYEEL 401
>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
[Homo sapiens]
Length = 2083
Score = 84.0 bits (206), Expect = 7e-16
Identities = 56/197 (28%), Positives = 101/197 (51%), Gaps = 13/197 (6%)
Query: 166 ILSAMNLDKFEKGPREIFH-----PEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEM 220
+LS + ++ ++K R FH ++ ++L L+ ++ K V + +GQ +
Sbjct: 1768 LLSILGMNSWDK--RRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSI 1825
Query: 221 FSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVST 280
+N GS+ ++ F+ LG + L G+ GGL KN +TG+ + Y E++FHVST
Sbjct: 1826 LTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVST 1884
Query: 281 MLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQND 340
+P S + ++ RH+GND V IV+ E ++ +I + F + +V Y +N
Sbjct: 1885 RMP-SDSDDSLTKKLRHLGNDEVHIVWSEHTRD---YRRGIIPTEFGDVL-IVIYPMKNH 1939
Query: 341 NYRLKIFSEESVPLFGP 357
+ ++I + VP FGP
Sbjct: 1940 MFSIQIMKKPEVPFFGP 1956
>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
[Homo sapiens]
Length = 2036
Score = 84.0 bits (206), Expect = 7e-16
Identities = 56/197 (28%), Positives = 101/197 (51%), Gaps = 13/197 (6%)
Query: 166 ILSAMNLDKFEKGPREIFH-----PEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEM 220
+LS + ++ ++K R FH ++ ++L L+ ++ K V + +GQ +
Sbjct: 1768 LLSILGMNSWDK--RRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSI 1825
Query: 221 FSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVST 280
+N GS+ ++ F+ LG + L G+ GGL KN +TG+ + Y E++FHVST
Sbjct: 1826 LTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNKSTGLTTPYFATSTVEVIFHVST 1884
Query: 281 MLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQND 340
+P S + ++ RH+GND V IV+ E ++ +I + F + +V Y +N
Sbjct: 1885 RMP-SDSDDSLTKKLRHLGNDEVHIVWSEHTRD---YRRGIIPTEFGDVL-IVIYPMKNH 1939
Query: 341 NYRLKIFSEESVPLFGP 357
+ ++I + VP FGP
Sbjct: 1940 MFSIQIMKKPEVPFFGP 1956
>gi|118600961 akt substrate AS250 [Homo sapiens]
Length = 1873
Score = 77.4 bits (189), Expect = 6e-14
Identities = 55/197 (27%), Positives = 102/197 (51%), Gaps = 13/197 (6%)
Query: 166 ILSAMNLDKFEKGPREIFH-----PEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEM 220
+L + ++ +++ R+ FH ++ ++L L+ ++ K V + +GQ +
Sbjct: 1607 LLDDLGMNSWDR--RKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSI 1664
Query: 221 FSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVST 280
SNE GS+ ++ F+ LG + L G+ GGL +N +TG + Y E++FHVST
Sbjct: 1665 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQ-RNGSTGQTAPYYATSTVEVIFHVST 1723
Query: 281 MLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQND 340
+P S + ++ RH+GND V IV+ E S ++ +I + F + +++ Y +N
Sbjct: 1724 RMP-SDSDDSLTKKLRHLGNDEVHIVW---SEHSRDYRRGIIPTAFGDV-SIIIYPMKNH 1778
Query: 341 NYRLKIFSEESVPLFGP 357
+ + I + VP FGP
Sbjct: 1779 MFFIAITKKPEVPFFGP 1795
>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
Length = 1740
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)
Query: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246
++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK
Sbjct: 1461 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1520
Query: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300
Y GGLD G +T +IM FH++T++P +K + ++KRH+GN
Sbjct: 1521 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1576
Query: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333
D V+IV+ + E FK I+ F + +V
Sbjct: 1577 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1606
>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
Length = 1807
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)
Query: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246
++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK
Sbjct: 1528 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1587
Query: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300
Y GGLD G +T +IM FH++T++P +K + ++KRH+GN
Sbjct: 1588 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1643
Query: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333
D V+IV+ + E FK I+ F + +V
Sbjct: 1644 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1673
>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
Length = 1784
Score = 66.6 bits (161), Expect = 1e-10
Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)
Query: 188 QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246
++ + +L++ K VL+ +GQ + + SNE GS + +FL LG I LK
Sbjct: 1505 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1564
Query: 247 TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300
Y GGLD G +T +IM FH++T++P +K + ++KRH+GN
Sbjct: 1565 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620
Query: 301 DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333
D V+IV+ + E FK I+ F + +V
Sbjct: 1621 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1650
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 954 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1011
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1012 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1067
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1068 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1107
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1108 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1166
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1167 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1217
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1218 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1254
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 962 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1019
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1020 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1075
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1076 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1115
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1116 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1174
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1175 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1225
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1226 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1262
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 983 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1040
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1041 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1096
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1097 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1136
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1137 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1195
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1196 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1246
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1247 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1283
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 991 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1048
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1049 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1104
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1105 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1144
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1145 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1203
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1204 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1254
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1255 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1291
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 1009 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1066
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1067 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1122
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1123 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1162
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1163 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1221
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1222 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1272
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1273 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1309
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 1017 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1074
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1075 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1130
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1131 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1170
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1171 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1229
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1230 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1280
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1281 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1317
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 1038 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1095
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1096 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1151
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1152 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1191
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1192 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1250
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1251 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1301
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1302 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1338
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 55/343 (16%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L++LV
Sbjct: 1046 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV--TI 1103
Query: 547 KGKDARLFVFRLSALQKGL--EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIV 604
GK +L V+ LS L+ + + K + LE GC Y + + R +V
Sbjct: 1104 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE---GCIHYKV-VKYERIKFLV 1159
Query: 605 VAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMTLVDGPA 663
+A++N + + + P +F + L P+ LVD
Sbjct: 1160 IALKNAVEIYA-----------------WAPKPYHKFMAFKSFADLQHKPL---LVDLTV 1199
Query: 664 EESDNLICVAYRHQ-FDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGLLLCY 719
EE L + H F V++ +G ++ ++ H++ N I DG +L+CY
Sbjct: 1200 EEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDG-MEMLVCY 1258
Query: 720 NYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFP-YLLAFTTDSMEIRLVVN 778
+Y D W + P ++ ++ + ++EIR V
Sbjct: 1259 EDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1309
Query: 779 GNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1310 GHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1346
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 49.7 bits (117), Expect = 1e-05
Identities = 89/348 (25%), Positives = 143/348 (41%), Gaps = 65/348 (18%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L+LL+
Sbjct: 998 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI--TI 1055
Query: 547 KGKDARLFVFRLSALQKGL-------EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSR 599
GK +L V+ LS L+ + E KQ + D +GC Y
Sbjct: 1056 SGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD--------MEGCGHY-------- 1099
Query: 600 ELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLV 659
R+V R K L+I K S+ + + P +F + +D P LV
Sbjct: 1100 --RVVKYERIKFLVIALK--------SSVEVYAWAPKPYHKFMAFKS--FADLPHRPLLV 1147
Query: 660 DGPAEESDNL-ICVAYRHQFDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGL 715
D EE L + F V+ +G ++ ++ H++ +++ A I + +
Sbjct: 1148 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ-SQITPHAIIFLPNTDGMEM 1206
Query: 716 LLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAP--YAIVCAFPYLLAFTTDSMEI 773
LLCY +Y G + D W + P A +C+ ++ + ++EI
Sbjct: 1207 LLCYEDEGVYVNTY----GRII-----KDVVLQWGEMPTSVAYICS-NQIMGWGEKAIEI 1256
Query: 774 RLVVNGNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
R V G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1257 RSVETGHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1298
Score = 30.8 bits (68), Expect = 6.7
Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 8/78 (10%)
Query: 910 RRELLGLSDEGGPKSE--GAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAS 967
RR G GP ++ G P A S P R + PG RS S G L A
Sbjct: 689 RRAERGTPKPPGPPAQPPGPPNASSNPDLRRSD------PGWERSDSVLPASHGHLPQAG 742
Query: 968 TSEANPEGHSASSDQDPV 985
+ E N G S+ D PV
Sbjct: 743 SLERNRVGVSSKPDSSPV 760
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 49.7 bits (117), Expect = 1e-05
Identities = 89/348 (25%), Positives = 143/348 (41%), Gaps = 65/348 (18%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L+LL+
Sbjct: 989 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI--TI 1046
Query: 547 KGKDARLFVFRLSALQKGL-------EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSR 599
GK +L V+ LS L+ + E KQ + D +GC Y
Sbjct: 1047 SGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD--------MEGCGHY-------- 1090
Query: 600 ELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLV 659
R+V R K L+I K S+ + + P +F + +D P LV
Sbjct: 1091 --RVVKYERIKFLVIALK--------SSVEVYAWAPKPYHKFMAFKS--FADLPHRPLLV 1138
Query: 660 DGPAEESDNL-ICVAYRHQFDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGL 715
D EE L + F V+ +G ++ ++ H++ +++ A I + +
Sbjct: 1139 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ-SQITPHAIIFLPNTDGMEM 1197
Query: 716 LLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAP--YAIVCAFPYLLAFTTDSMEI 773
LLCY +Y G + D W + P A +C+ ++ + ++EI
Sbjct: 1198 LLCYEDEGVYVNTY----GRII-----KDVVLQWGEMPTSVAYICS-NQIMGWGEKAIEI 1247
Query: 774 RLVVNGNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
R V G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1248 RSVETGHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1289
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 49.7 bits (117), Expect = 1e-05
Identities = 89/348 (25%), Positives = 143/348 (41%), Gaps = 65/348 (18%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L+LL+
Sbjct: 1018 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI--TI 1075
Query: 547 KGKDARLFVFRLSALQKGL-------EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSR 599
GK +L V+ LS L+ + E KQ + D +GC Y
Sbjct: 1076 SGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD--------MEGCGHY-------- 1119
Query: 600 ELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLV 659
R+V R K L+I K S+ + + P +F + +D P LV
Sbjct: 1120 --RVVKYERIKFLVIALK--------SSVEVYAWAPKPYHKFMAFKS--FADLPHRPLLV 1167
Query: 660 DGPAEESDNL-ICVAYRHQFDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGL 715
D EE L + F V+ +G ++ ++ H++ +++ A I + +
Sbjct: 1168 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ-SQITPHAIIFLPNTDGMEM 1226
Query: 716 LLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAP--YAIVCAFPYLLAFTTDSMEI 773
LLCY +Y G + D W + P A +C+ ++ + ++EI
Sbjct: 1227 LLCYEDEGVYVNTY----GRII-----KDVVLQWGEMPTSVAYICS-NQIMGWGEKAIEI 1276
Query: 774 RLVVNGNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
R V G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1277 RSVETGHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1318
Score = 30.8 bits (68), Expect = 6.7
Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 8/78 (10%)
Query: 910 RRELLGLSDEGGPKSE--GAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESAS 967
RR G GP ++ G P A S P R + PG RS S G L A
Sbjct: 709 RRAERGTPKPPGPPAQPPGPPNASSNPDLRRSD------PGWERSDSVLPASHGHLPQAG 762
Query: 968 TSEANPEGHSASSDQDPV 985
+ E N G S+ D PV
Sbjct: 763 SLERNRVGVSSKPDSSPV 780
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 49.7 bits (117), Expect = 1e-05
Identities = 89/348 (25%), Positives = 143/348 (41%), Gaps = 65/348 (18%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVD-DDLPSVPVFDRTLPVKQMHVLETLDLLVLRAD 546
F E +CA WG LLV T+ G++L+D V +QM VLE L+LL+
Sbjct: 981 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI--TI 1038
Query: 547 KGKDARLFVFRLSALQKGL-------EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSR 599
GK +L V+ LS L+ + E KQ + D +GC Y
Sbjct: 1039 SGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD--------MEGCGHY-------- 1082
Query: 600 ELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLV 659
R+V R K L+I K S+ + + P +F + +D P LV
Sbjct: 1083 --RVVKYERIKFLVIALK--------SSVEVYAWAPKPYHKFMAFKS--FADLPHRPLLV 1130
Query: 660 DGPAEESDNL-ICVAYRHQFDVVNESTGEAFRLH---HVEANRVNFVAAIDVYEDGEAGL 715
D EE L + F V+ +G ++ ++ H++ +++ A I + +
Sbjct: 1131 DLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ-SQITPHAIIFLPNTDGMEM 1189
Query: 716 LLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAP--YAIVCAFPYLLAFTTDSMEI 773
LLCY +Y G + D W + P A +C+ ++ + ++EI
Sbjct: 1190 LLCYEDEGVYVNTY----GRII-----KDVVLQWGEMPTSVAYICS-NQIMGWGEKAIEI 1239
Query: 774 RLVVNGNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
R V G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1240 RSVETGHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1281
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 46.2 bits (108), Expect = 2e-04
Identities = 89/349 (25%), Positives = 139/349 (39%), Gaps = 67/349 (19%)
Query: 488 FPHEAVCADPWGQALLVSTDAGVLLVDDDLPS--VPVFDRTLPVKQMHVLETLDLLVLRA 545
F E +CA WG LLV T++G++L+D P+ +R +QM VLE L++LV
Sbjct: 898 FNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRR-RFQQMDVLEGLNVLV--T 954
Query: 546 DKGKDARLFVFRLSALQKGL-------EGKQAGKSRSDCRENKLEKTKGCHLYAINTHHS 598
GK +L V+ LS L+ + E KQ + D +GC Y
Sbjct: 955 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD--------LEGCVHY------- 999
Query: 599 RELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREIC-LSDSPMVMT 657
++V R K L+I K S+ + + P +F + L P+
Sbjct: 1000 ---KVVKYERIKFLVIALK--------SSVEVYAWAPKPYHKFMAFKSFGELVHKPL--- 1045
Query: 658 LVDGPAEESDNLICV----AYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEA 713
LVD EE L + A H DV + S + + H++ + I DG
Sbjct: 1046 LVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDG-M 1104
Query: 714 GLLLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIV-CAFPYLLAFTTDSME 772
LL+CY +Y D W + P ++ + + ++E
Sbjct: 1105 ELLVCYEDEGVYVNT---------YGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIE 1155
Query: 773 IRLVVNGNL----VHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSK 817
IR V G+L +H +L+ + R+D F A+ V SGGSS+
Sbjct: 1156 IRSVETGHLDGVFMHKR-AQRLKFLCERNDKVFFAS-----VRSGGSSQ 1198
Score = 30.4 bits (67), Expect = 8.8
Identities = 27/93 (29%), Positives = 39/93 (41%), Gaps = 9/93 (9%)
Query: 904 EIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSL 963
E A R R + D + +P+A+SK R+ E P RS S S S+
Sbjct: 530 EPADRARE----VEDRFRKTNHSSPEAQSKQTGRVLEP-----PVPSRSESFSNGNSESV 580
Query: 964 ESASTSEANPEGHSASSDQDPVADREGSPVSGS 996
A A P+ ++ + PV R SP+ GS
Sbjct: 581 HPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGS 613
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,167,895
Number of Sequences: 37866
Number of extensions: 1926303
Number of successful extensions: 7701
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 7353
Number of HSP's gapped (non-prelim): 395
length of query: 1013
length of database: 18,247,518
effective HSP length: 112
effective length of query: 901
effective length of database: 14,006,526
effective search space: 12619879926
effective search space used: 12619879926
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.