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Search of human proteins with 20357529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
(340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 702 0.0
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 648 0.0
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 647 0.0
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 593 e-170
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 369 e-102
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 369 e-102
gi|32189425 WD repeat domain 69 [Homo sapiens] 119 3e-27
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 119 3e-27
gi|21071067 TBP-associated factor 5 [Homo sapiens] 112 5e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 110 1e-24
gi|16554627 WD repeat domain 5 [Homo sapiens] 110 1e-24
gi|23199987 WD repeat domain 5B [Homo sapiens] 109 3e-24
gi|113865883 WD repeat domain 38 [Homo sapiens] 109 4e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 108 9e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 108 9e-24
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 104 1e-22
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 102 4e-22
gi|26665869 WD repeat domain 51B [Homo sapiens] 102 5e-22
gi|13376840 WD repeat domain 61 [Homo sapiens] 100 2e-21
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 99 7e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 97 2e-20
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 97 2e-20
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 97 2e-20
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 97 2e-20
gi|19913367 transducin beta-like 1Y [Homo sapiens] 96 6e-20
gi|19913365 transducin beta-like 1Y [Homo sapiens] 96 6e-20
gi|15150805 transducin beta-like 1Y [Homo sapiens] 96 6e-20
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 95 1e-19
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 95 1e-19
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 95 1e-19
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 702 bits (1813), Expect = 0.0
Identities = 340/340 (100%), Positives = 340/340 (100%)
Query: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
Query: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF
Sbjct: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA
Sbjct: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
Query: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM
Sbjct: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 648 bits (1671), Expect = 0.0
Identities = 307/340 (90%), Positives = 323/340 (95%)
Query: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
MSEL+QLRQEAEQL+NQIRDARKAC D+TL+QIT +DPVGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN+VACGGLDNI
Sbjct: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
CSIY+LKTREGNVRVSREL GHTGYLSCCRFLDDNQI+TSSGDTTCALWDIETGQQT F
Sbjct: 121 CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF 180
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
GH+GDVMSLSLAPD R FVSGACDAS KLWDVR+ MCRQTF GHESDINA+ FFPNG A
Sbjct: 181 TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA 240
Query: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
F TGSDDATCRLFDLRADQEL+ YSHDNIICGITSV+FS+SGRLLLAGYDDFNCN+WDA+
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
K DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 647 bits (1668), Expect = 0.0
Identities = 306/340 (90%), Positives = 324/340 (95%)
Query: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
MSELEQLRQEAEQLRNQI+DARKAC D+TL QIT+ +D VGRIQMRTRRTLRGHLAKIYA
Sbjct: 1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
MHWG DSRLLVSASQDGKLIIWDSYTTNK+HAIPLRSSWVMTCAYAPSGN+VACGGLDNI
Sbjct: 61 MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI 120
Query: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
CSIY+LKTREGNVRVSRELPGHTGYLSCCRFLDD+QI+TSSGDTTCALWDIET QQT F
Sbjct: 121 CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF 180
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
GHSGDVMSLSL+PD RTFVSGACDAS KLWD+RD MCRQ+F GH SDINAV+FFPNGYA
Sbjct: 181 TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA 240
Query: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
F TGSDDATCRLFDLRADQELL+YSHDNIICGITSVAFS+SGRLLLAGYDDFNCN+WD +
Sbjct: 241 FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL+IWN
Sbjct: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 593 bits (1528), Expect = e-170
Identities = 275/340 (80%), Positives = 306/340 (90%)
Query: 1 MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA 60
M E+EQLRQEAEQL+ QI DARKAC D TL ++ +GL+ VGR+QMRTRRTLRGHLAKIYA
Sbjct: 1 MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYA 60
Query: 61 MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI 120
MHW TDS+LLVSASQDGKLI+WDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDN+
Sbjct: 61 MHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNM 120
Query: 121 CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF 180
CSIY+LK+REGNV+VSREL HTGYLSCCRFLDDN I+TSSGDTTCALWDIETGQQ F
Sbjct: 121 CSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVF 180
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
GH+GD MSL+++PD F+SGACDAS KLWDVR+ CRQTF GHESDINA+ FFPNG A
Sbjct: 181 VGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEA 240
Query: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
TGSDDA+CRLFDLRADQEL+ +SH++IICGITSVAFS SGRLL AGYDDFNCN+WD+M
Sbjct: 241 ICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSM 300
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
K +R G+L+GHDNRVSCLGVT DGMAVATGSWDSFLKIWN
Sbjct: 301 KSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 369 bits (946), Expect = e-102
Identities = 177/341 (51%), Positives = 232/341 (68%), Gaps = 5/341 (1%)
Query: 4 LEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHW 63
L L+ EAE L+ ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W
Sbjct: 12 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 71
Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSI 123
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 72 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 131
Query: 124 YSLK--TREGNVRVSRELPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGF 180
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+GQ F
Sbjct: 132 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 191
Query: 181 AGHSGDVMSLSLAPD--GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNG 238
GH DV+ L LAP G TFVSG CD +WD+R C Q F HESDIN+V ++P+G
Sbjct: 192 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 251
Query: 239 YAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
AF +GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ N+WD
Sbjct: 252 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
Query: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
+KG R +L GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 312 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 64.3 bits (155), Expect = 1e-10
Identities = 49/215 (22%), Positives = 92/215 (42%), Gaps = 7/215 (3%)
Query: 133 VRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLS 191
++ R L GH + C + D + I++SS D +WD T + VM+ +
Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112
Query: 192 LAPDGRTFVSGACDASIKLW----DVRDSMC--RQTFIGHESDINAVAFFPNGYAFTTGS 245
AP G G D ++ D ++M +++ H + ++A +F + T S
Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172
Query: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
D TC L+D+ + Q L + +A S +G ++G D +WD G
Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
H++ ++ + G A A+GS D+ ++++
Sbjct: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 369 bits (946), Expect = e-102
Identities = 177/341 (51%), Positives = 232/341 (68%), Gaps = 5/341 (1%)
Query: 4 LEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHW 63
L L+ EAE L+ ++ + R D L Q+ ++ +G+ M+TRRTL+GH K+ M W
Sbjct: 54 LASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDW 113
Query: 64 GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSI 123
D R +VS+SQDGK+I+WDS+TTNK HA+ + +WVM CAYAPSG +ACGGLDN CS+
Sbjct: 114 CKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSV 173
Query: 124 YSLK--TREGNVRVSRELPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGF 180
Y L E + + HT YLS C F + D QI+T+SGD TCALWD+E+GQ F
Sbjct: 174 YPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSF 233
Query: 181 AGHSGDVMSLSLAPD--GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNG 238
GH DV+ L LAP G TFVSG CD +WD+R C Q F HESDIN+V ++P+G
Sbjct: 234 HGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSG 293
Query: 239 YAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
AF +GSDDATCRL+DLRAD+E+ +YS ++II G +SV FS SGRLL AGY+D+ N+WD
Sbjct: 294 DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
Query: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
+KG R +L GH+NRVS L V+ DG A +GSWD L++W
Sbjct: 354 VLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 64.3 bits (155), Expect = 1e-10
Identities = 49/215 (22%), Positives = 92/215 (42%), Gaps = 7/215 (3%)
Query: 133 VRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLS 191
++ R L GH + C + D + I++SS D +WD T + VM+ +
Sbjct: 95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 154
Query: 192 LAPDGRTFVSGACDASIKLW----DVRDSMC--RQTFIGHESDINAVAFFPNGYAFTTGS 245
AP G G D ++ D ++M +++ H + ++A +F + T S
Sbjct: 155 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 214
Query: 246 DDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA 305
D TC L+D+ + Q L + +A S +G ++G D +WD G
Sbjct: 215 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
Query: 306 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
H++ ++ + G A A+GS D+ ++++
Sbjct: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 119 bits (299), Expect = 3e-27
Identities = 84/333 (25%), Positives = 142/333 (42%), Gaps = 46/333 (13%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA-P 107
+ L+ H+ + + ++ S D +WD+ + +++ + + V A+ P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 108 SGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTC 166
G+ +A G D C ++S++T + GHT + C F + ++ T S DTT
Sbjct: 146 YGDKIATGSFDKTCKLWSVETG----KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHE 226
LWDI+ G++ GHS +++SLS G ++G+ D ++ +WD IGH
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 227 SDINAVAFFPNGYAFTTGSDDATCRLFDLRA----------DQELL-------------- 262
++I++ +F + TGS D TC+L+D D E+L
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 263 -------MYSHDNIIC---------GITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAG 306
++S C I+ ++F+ G LL G D IWDA G
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Query: 307 VLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
VL GH + + G V TGS D+ +IW
Sbjct: 382 VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 113 bits (283), Expect = 2e-25
Identities = 78/260 (30%), Positives = 123/260 (47%), Gaps = 25/260 (9%)
Query: 89 KVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSC 148
K H +PL + A SG+ G D C ++ + E L GH +
Sbjct: 89 KAHILPLTN-----VALNKSGSCFITGSYDRTCKLWDTASGEE----LNTLEGHRNVVYA 139
Query: 149 CRFLDD--NQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDA 206
F + ++I T S D TC LW +ETG+ F GH+ +++ LS P +G+ D
Sbjct: 140 IAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDT 199
Query: 207 SIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSH 266
+ KLWD+++ T GH ++I +++F +G TGS D T ++D +++
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV----- 254
Query: 267 DNIICG----ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRV--SCLGV 320
NI+ G I+S +F+ L+L G D C +WDA G L GHD+ + SC
Sbjct: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
Query: 321 TDDGMAVATGSWDSFLKIWN 340
T G +AT S D +I++
Sbjct: 314 T--GKLIATASADGTARIFS 331
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 119 bits (299), Expect = 3e-27
Identities = 81/291 (27%), Positives = 132/291 (45%), Gaps = 22/291 (7%)
Query: 62 HWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG---------NFV 112
H+ +S++L +A G +W N +H + ++ V + P N
Sbjct: 238 HFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLA 297
Query: 113 ACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTCALWDI 171
+C D ++SL + E ++ GHT ++ + + + T+ D + LWD+
Sbjct: 298 SCAA-DGSVKLWSLDSDEPVA----DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352
Query: 172 ETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINA 231
E ++ + GHS V ++ DG +G DA ++WD+R C GH +I
Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412
Query: 232 VAFFPNGYAFTTGSDDATCRLFDLRADQELLMY---SHDNIICGITSVAFSRSGRLLLAG 288
+ F PNGY TGS D TC+++DLR Q +Y +H N++ G+ G LL G
Sbjct: 413 INFSPNGYHIATGSGDNTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPI--HGNFLLTG 468
Query: 289 YDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
D IW LAGH+ +V L ++ DG +AT S+D K+W
Sbjct: 469 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 78.2 bits (191), Expect = 1e-14
Identities = 55/204 (26%), Positives = 90/204 (44%), Gaps = 11/204 (5%)
Query: 146 LSCCRFLDDNQII-TSSGDTTCALWDIETGQQTVGFAGHSGDV--------MSLSLAPDG 196
+S C F +++++ T+ C LW + GH+ +V ++SL P
Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293
Query: 197 RTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLR 256
S A D S+KLW + GH + V + P+G T D + RL+DL
Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Query: 257 ADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVS 316
A +E+L ++ G+ +AF + G L G D +WD G L GH +
Sbjct: 354 AQEEILHQEGHSM--GVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY 411
Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340
+ + +G +ATGS D+ K+W+
Sbjct: 412 GINFSPNGYHIATGSGDNTCKVWD 435
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/205 (24%), Positives = 80/205 (39%), Gaps = 6/205 (2%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
+ GH ++ + W R L + D +WD ++ S V A+ G+
Sbjct: 319 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGS 378
Query: 111 FVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN-QIITSSGDTTCALW 169
GGLD ++ L+T R L GH + F + I T SGD TC +W
Sbjct: 379 LAGTGGLDAFGRVWDLRTG----RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
Query: 170 DIETGQQTVGFAGHSGDVMSLSLAP-DGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
D+ + H V + P G ++GA D + K+W +T GHE
Sbjct: 435 DLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK 494
Query: 229 INAVAFFPNGYAFTTGSDDATCRLF 253
+ + +G T S D T +L+
Sbjct: 495 VMGLDISSDGQLIATCSYDRTFKLW 519
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 112 bits (280), Expect = 5e-25
Identities = 71/204 (34%), Positives = 100/204 (49%), Gaps = 5/204 (2%)
Query: 139 LPGHTGYLSCCRFLDD-NQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197
L GH+G + F D N +++SS D T LW ++T VG+ GH+ V +P G
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD-LR 256
FVSG D +LW + F GH +D+N F PN TGS D T RL+D L
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 257 ADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVS 316
+ + H I S+ FS +GR L G D +WD G G L GH + V
Sbjct: 659 GNCVRIFTGHKG---PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 317 CLGVTDDGMAVATGSWDSFLKIWN 340
L + DG +A+GS D+ +++W+
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739
Score = 103 bits (257), Expect = 2e-22
Identities = 61/215 (28%), Positives = 103/215 (47%), Gaps = 6/215 (2%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+ L GH +Y + D L+S+S+DG + +W T + + V ++P
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCA 167
G + GG D + +++ + + R GH ++C RF + N + T S D T
Sbjct: 597 GYYFVSGGHDRVARLWA----TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227
LWD+ G F GH G + SL+ +P+GR +GA D + LWD+ + GH
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFD-LRADQEL 261
+ ++ F +G +GS D T RL+D ++A ++L
Sbjct: 713 TVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDL 747
Score = 93.6 bits (231), Expect = 2e-19
Identities = 67/247 (27%), Positives = 111/247 (44%), Gaps = 9/247 (3%)
Query: 57 KIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGG 116
K+ ++ +D L+ S D I D T +++ + S V +++P N++
Sbjct: 503 KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 562
Query: 117 LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIETGQ 175
D ++SL+T V GH + +F S G D LW + Q
Sbjct: 563 EDGTVRLWSLQTFTCLVGYK----GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618
Query: 176 QTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFF 235
FAGH DV P+ +G+ D +++LWDV + C + F GH+ I+++ F
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678
Query: 236 PNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNC 294
PNG TG+ D L+D+ + + H + +C S+ FSR G +L +G D
Sbjct: 679 PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC---SLRFSRDGEILASGSMDNTV 735
Query: 295 NIWDAMK 301
+WDA+K
Sbjct: 736 RLWDAIK 742
Score = 80.9 bits (198), Expect = 2e-15
Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 2/188 (1%)
Query: 153 DDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWD 212
D + I S D + D +T + GHSG V S +PD +S + D +++LW
Sbjct: 512 DLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWS 571
Query: 213 VRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICG 272
++ C + GH + F P GY F +G D RL+ Q L +++ +
Sbjct: 572 LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA--GHLAD 629
Query: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
+ F + + G D +WD + G+ + GH + L + +G +ATG+
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
Query: 333 DSFLKIWN 340
D + +W+
Sbjct: 690 DGRVLLWD 697
Score = 57.4 bits (137), Expect = 2e-08
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 9/143 (6%)
Query: 33 ITAGLDPVGRI----QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTN 88
++ G D V R+ + R GHLA + + +S + + S D + +WD N
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 89 KVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSC 148
V + + ++P+G F+A G D ++ + G+ + EL GHT +
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI----GHGLMVGELKGHTDTVCS 716
Query: 149 CRFLDDNQIITS-SGDTTCALWD 170
RF D +I+ S S D T LWD
Sbjct: 717 LRFSRDGEILASGSMDNTVRLWD 739
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (276), Expect = 1e-24
Identities = 68/246 (27%), Positives = 114/246 (46%), Gaps = 11/246 (4%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHT-GYLSCCRFLDDNQII 158
V + ++P+G ++A D + I+ + + + + GH G D N ++
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC 218
++S D T +WD+ +G+ GHS V + P VSG+ D S+++WDV+ C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVA 277
+T H ++AV F +G + S D CR++D + Q L + DN ++ V
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVK 221
Query: 278 FSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDS 334
FS +G+ +LA D +WD KG GH N C+ G + +GS D+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 335 FLKIWN 340
+ IWN
Sbjct: 282 LVYIWN 287
Score = 101 bits (251), Expect = 1e-21
Identities = 63/224 (28%), Positives = 107/224 (47%), Gaps = 9/224 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100
G + +T+ GH I + W +DS LLVSAS D L IWD + + + S++V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 101 MTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIIT 159
C + P N + G D I+ +KT + + LP H+ +S F D + I++
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMS-LSLAPDGRTFVSGACDASIKLWDVRDSMC 218
SS D C +WD +GQ +S + +P+G+ ++ D ++KLWD C
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 219 RQTFIGHESD---INAVAFFPNGYAFTTGSDDATCRLFDLRADQ 259
+T+ GH+++ I A G +GS+D +++L+ +
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 100 bits (249), Expect = 2e-21
Identities = 73/295 (24%), Positives = 129/295 (43%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D + IW +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCAL 168
N + D I+ + + + + L GH+ Y+ CC F N I++ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES- 227
WD++TG+ HS V ++ DG VS + D ++WD C +T I ++
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGITSVAFSRSGRLLL 286
++ V F PNG + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNIWDAMKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIW 339
+G +D IW+ + L GH + V + T++ +A A D +K+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.1 bits (196), Expect = 3e-15
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 4/161 (2%)
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
AGH+ V S+ +P+G S + D IK+W D +T GH+ I+ VA+ +
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 241 FTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDA 299
+ SDD T +++D+ + + L + H N + F+ L+++G D + IWD
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 300 MKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
G L H + VS + DG + + S+D +IW+
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 33.5 bits (75), Expect = 0.28
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 49 RTLRGHLAK---IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
+T GH + I+A T + +VS S+D + IW+ T V + + V++ A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 106 APSGNFVACGGLDN 119
P+ N +A L+N
Sbjct: 310 HPTENIIASAALEN 323
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 110 bits (276), Expect = 1e-24
Identities = 68/246 (27%), Positives = 114/246 (46%), Gaps = 11/246 (4%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHT-GYLSCCRFLDDNQII 158
V + ++P+G ++A D + I+ + + + + GH G D N ++
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 159 TSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC 218
++S D T +WD+ +G+ GHS V + P VSG+ D S+++WDV+ C
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
Query: 219 RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVA 277
+T H ++AV F +G + S D CR++D + Q L + DN ++ V
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVK 221
Query: 278 FSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDS 334
FS +G+ +LA D +WD KG GH N C+ G + +GS D+
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281
Query: 335 FLKIWN 340
+ IWN
Sbjct: 282 LVYIWN 287
Score = 101 bits (251), Expect = 1e-21
Identities = 63/224 (28%), Positives = 107/224 (47%), Gaps = 9/224 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100
G + +T+ GH I + W +DS LLVSAS D L IWD + + + S++V
Sbjct: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
Query: 101 MTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIIT 159
C + P N + G D I+ +KT + + LP H+ +S F D + I++
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMS-LSLAPDGRTFVSGACDASIKLWDVRDSMC 218
SS D C +WD +GQ +S + +P+G+ ++ D ++KLWD C
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Query: 219 RQTFIGHESD---INAVAFFPNGYAFTTGSDDATCRLFDLRADQ 259
+T+ GH+++ I A G +GS+D +++L+ +
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 100 bits (249), Expect = 2e-21
Identities = 73/295 (24%), Positives = 129/295 (43%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D + IW +Y I + A++
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCAL 168
N + D I+ + + + + L GH+ Y+ CC F N I++ S D + +
Sbjct: 100 NLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES- 227
WD++TG+ HS V ++ DG VS + D ++WD C +T I ++
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGITSVAFSRSGRLLL 286
++ V F PNG + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 287 AGYDDFNCNIWDAMKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIW 339
+G +D IW+ + L GH + V + T++ +A A D +K+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.1 bits (196), Expect = 3e-15
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 4/161 (2%)
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
AGH+ V S+ +P+G S + D IK+W D +T GH+ I+ VA+ +
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 241 FTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDA 299
+ SDD T +++D+ + + L + H N + F+ L+++G D + IWD
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 300 MKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
G L H + VS + DG + + S+D +IW+
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 33.5 bits (75), Expect = 0.28
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 49 RTLRGHLAK---IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
+T GH + I+A T + +VS S+D + IW+ T V + + V++ A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 106 APSGNFVACGGLDN 119
P+ N +A L+N
Sbjct: 310 HPTENIIASAALEN 323
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 109 bits (273), Expect = 3e-24
Identities = 72/284 (25%), Positives = 130/284 (45%), Gaps = 23/284 (8%)
Query: 74 SQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA------------YAPSGNFVACGGLDNIC 121
S+D K + S + N+ +P ++ + C ++P+G ++A D +
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 122 SIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN-QIITSSGDTTCALWDIETGQQTVGF 180
I+ + + + L GH +S + D+ +++++S D T LWD+ +G+
Sbjct: 66 IIWGAY----DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121
Query: 181 AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA 240
GHS V + P +SG+ D ++K+W+V+ C +T H ++AV F +G
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 241 FTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDA 299
+GS D CR++D + Q L + DN ++ V FS +G+ +L D +WD
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDN--PPVSFVKFSPNGKYILTATLDNTLKLWDY 239
Query: 300 MKGDRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDSFLKIWN 340
+G GH N C+ G + +GS D+ + IWN
Sbjct: 240 SRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 100 bits (248), Expect = 2e-21
Identities = 72/295 (24%), Positives = 134/295 (45%), Gaps = 9/295 (3%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL GH + ++ + + L S+S D +IIW +Y + + + A++
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCAL 168
+ + D ++ +++ + + L GH+ Y+ CC F N II+ S D T +
Sbjct: 96 SRLVSASDDKTLKLWDVRSG----KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES- 227
W+++TG+ + HS V ++ G VSG+ D ++WD C +T + ++
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGITSVAFSRSGRLLL 286
++ V F PNG T + D T +L+D + L Y+ H N I + G+ ++
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 287 AGYDDFNCNIWDAMKGDRAGVLAGHDNRV--SCLGVTDDGMAVATGSWDSFLKIW 339
+G +D IW+ + L GH + V + T++ +A A D +K+W
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 92.4 bits (228), Expect = 5e-19
Identities = 59/224 (26%), Positives = 104/224 (46%), Gaps = 9/224 (4%)
Query: 41 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 100
G + +TL GH +I + W +DS LVSAS D L +WD + + + S++V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 101 MTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIIT 159
C + P N + G D I+ +KT + + L H+ +S F + I++
Sbjct: 129 FCCNFNPPSNLIISGSFDETVKIWEVKTG----KCLKTLSAHSDPVSAVHFNCSGSLIVS 184
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMS-LSLAPDGRTFVSGACDASIKLWDVRDSMC 218
S D C +WD +GQ +S + +P+G+ ++ D ++KLWD C
Sbjct: 185 GSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRC 244
Query: 219 RQTFIGHESD---INAVAFFPNGYAFTTGSDDATCRLFDLRADQ 259
+T+ GH+++ I A G +GS+D +++L+ +
Sbjct: 245 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288
Score = 34.7 bits (78), Expect = 0.13
Identities = 22/77 (28%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
Query: 46 RTRRTLRGHLAK---IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102
R +T GH + I+A T + +VS S+D + IW+ T V + + V++
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 302
Query: 103 CAYAPSGNFVACGGLDN 119
A P+ N +A L+N
Sbjct: 303 AACHPTENLIASAALEN 319
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 109 bits (272), Expect = 4e-24
Identities = 70/243 (28%), Positives = 111/243 (45%), Gaps = 7/243 (2%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
V + A++P G + G D +Y +TR G ++ L GHTG + CRF D +
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGC--VYGWETRSG--QLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 160 SSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC 218
S+ D T LWD+ + GH V ++S +PD R SG D + LWDV+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 219 RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSH-DNIICGITSVA 277
+ +GH I + F P TGS D+T ++DLR + + + I+ +
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 278 FSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLK 337
+S SG LL +G D +IW L GH V + + D + +A+ + +K
Sbjct: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 338 IWN 340
+W+
Sbjct: 259 VWD 261
Score = 106 bits (265), Expect = 3e-23
Identities = 63/203 (31%), Positives = 98/203 (48%), Gaps = 9/203 (4%)
Query: 142 HTGYLSCCRFLDDNQIITSSGDTTCAL-WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200
H G ++ F D Q++ + + C W+ +GQ GH+G V +PDG F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260
S +CD +++LWDV + C + GH+ + V+F P+ +G D L+D+++ Q
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 261 L-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRA---GVLAGHDNRVS 316
L L+ H + I S FS + L G D +IWD A L GH +S
Sbjct: 140 LRLLVGHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANIS 196
Query: 317 CLGVTDDGMAVATGSWDSFLKIW 339
CL + G+ +A+GSWD + IW
Sbjct: 197 CLCYSASGL-LASGSWDKTIHIW 218
Score = 87.4 bits (215), Expect = 2e-17
Identities = 49/162 (30%), Positives = 78/162 (48%), Gaps = 4/162 (2%)
Query: 180 FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGY 239
F H G+V S + +PDG+ ++G+ D + W+ R GH + F P+G+
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 240 AFTTGSDDATCRLFDL-RADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
F + S D T RL+D+ RA ++ H + +V+FS R L +G D +WD
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQR---SVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
G +L GH + + + +ATGSWDS + IW+
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 175
Score = 86.3 bits (212), Expect = 4e-17
Identities = 64/285 (22%), Positives = 124/285 (43%), Gaps = 13/285 (4%)
Query: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVA 113
H ++ + + D ++L++ S+DG + W++ + + + + V C ++P G+ A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 114 CGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIE 172
D ++ + + R L GH + F D++ + S G D LWD++
Sbjct: 80 SASCDCTVRLWDV----ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 173 TGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR---DSMCRQTFIGHESDI 229
+GQ GH + S +P +G+ D+++ +WD+R ++ Q GH ++I
Sbjct: 136 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 230 NAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGR-LLLAG 288
+ + + +G +GS D T ++ + L+ + + S+AFS L AG
Sbjct: 196 SCLCYSASG-LLASGSWDKTIHIW--KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAG 252
Query: 289 YDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
Y +WD G L G + T DG + +G+ D
Sbjct: 253 YSRM-VKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 85.9 bits (211), Expect = 5e-17
Identities = 51/203 (25%), Positives = 89/203 (43%), Gaps = 1/203 (0%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R L+GH + + + DSR L S D ++++WD + + + + + ++P+
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPT 158
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCAL 168
N +A G D+ I+ L+ V + L GH+ +SC + + + S D T +
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVS-HQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
W T + GH V S++ +PD S +K+WD C +T G
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 229 INAVAFFPNGYAFTTGSDDATCR 251
+ AF P+G +G+ D T R
Sbjct: 278 AHTCAFTPDGKILVSGAADQTRR 300
Score = 65.9 bits (159), Expect = 5e-11
Identities = 54/245 (22%), Positives = 102/245 (41%), Gaps = 11/245 (4%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGN 110
L GH + + D L SAS D + +WD + + V T +++P
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 111 FVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDD-NQIITSSGDTTCALW 169
+A GG D ++ +++ + + R L GH + F N + T S D+T +W
Sbjct: 119 QLASGGWDKRVMLWDVQSGQ----MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Query: 170 DIETGQQTV---GFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHE 226
D+ V GHS ++ L + G SG+ D +I +W S GH
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHV 233
Query: 227 SDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLL 286
+ + ++AF P+ + +++D + + + ++ + AF+ G++L+
Sbjct: 234 TWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK--CLETLKGVLDVAHTCAFTPDGKILV 291
Query: 287 AGYDD 291
+G D
Sbjct: 292 SGAAD 296
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 108 bits (269), Expect = 9e-24
Identities = 72/292 (24%), Positives = 122/292 (41%), Gaps = 7/292 (2%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH + + + +++ L S S D L++W ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCA 167
G+ +A G D I+ + +G V R HT + F D Q +T+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227
+W + + H V +PDGR VS + D ++KLWD C ++ H
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLA 287
+ V F P+G D T +++D+R + L Y + + ++F SG L+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS--AAVNGLSFHPSGNYLIT 246
Query: 288 GYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
D I D M+G L GH + + + G A+G D + +W
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/207 (23%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 135 VSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLA 193
+ R GH ++C F ++ Q+ + S D+ +W ++ + F GH V ++ +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLF 253
P G SG+ D ++++W F H + + +V F +G +F T SDD T +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDN 313
++ ++S I + FS GRL+++ DD +WD + H
Sbjct: 131 --ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTDDGMAVATGSWDSFLKIWN 340
V+ + G +A D+ +K+W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 47.8 bits (112), Expect = 1e-05
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 4/126 (3%)
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGI 273
D + F GH + V F N +GS D+ ++ ++ ++ H + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD---AV 64
Query: 274 TSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
T V FS SG LL +G D IW + V H V + DG + T S D
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 334 SFLKIW 339
+K+W
Sbjct: 125 KTVKVW 130
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 108 bits (269), Expect = 9e-24
Identities = 72/292 (24%), Positives = 122/292 (41%), Gaps = 7/292 (2%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH + + + +++ L S S D L++W ++ + V ++PS
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCA 167
G+ +A G D I+ + +G V R HT + F D Q +T+S D T
Sbjct: 73 GHLLASGSRDKTVRIW-VPNVKGESTVFR---AHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227
+W + + H V +PDGR VS + D ++KLWD C ++ H
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLA 287
+ V F P+G D T +++D+R + L Y + + ++F SG L+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHS--AAVNGLSFHPSGNYLIT 246
Query: 288 GYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
D I D M+G L GH + + + G A+G D + +W
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/207 (23%), Positives = 93/207 (44%), Gaps = 3/207 (1%)
Query: 135 VSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLA 193
+ R GH ++C F ++ Q+ + S D+ +W ++ + F GH V ++ +
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 194 PDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLF 253
P G SG+ D ++++W F H + + +V F +G +F T SDD T +++
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 254 DLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDN 313
++ ++S I + FS GRL+++ DD +WD + H
Sbjct: 131 --ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 314 RVSCLGVTDDGMAVATGSWDSFLKIWN 340
V+ + G +A D+ +K+W+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWD 215
Score = 47.8 bits (112), Expect = 1e-05
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 4/126 (3%)
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGI 273
D + F GH + V F N +GS D+ ++ ++ ++ H + +
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD---AV 64
Query: 274 TSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
T V FS SG LL +G D IW + V H V + DG + T S D
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDD 124
Query: 334 SFLKIW 339
+K+W
Sbjct: 125 KTVKVW 130
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 104 bits (259), Expect = 1e-22
Identities = 58/203 (28%), Positives = 103/203 (50%), Gaps = 3/203 (1%)
Query: 139 LPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197
L GH G + RFL D+ +++ S D + WD+ + TV + GH+ V L ++P
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRA 257
F SG+ D + +LW + + + GH +D++ V F PN TGS D T RL+ +
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 258 DQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSC 317
+ +++ + S+AFS +G+ L + +D +WD G L GH + ++
Sbjct: 458 GNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340
L + D +A+ S D+ +++W+
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWD 538
Score = 95.1 bits (235), Expect = 8e-20
Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKV---HAIPLRSSWVMTC 103
+ LRGH +Y+ + DS L+S S+D + WD S+T + HA P+ W +
Sbjct: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
Query: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFL-DDNQIITSSG 162
+ P + A G D ++S R +R+ GH + C +F + N + T S
Sbjct: 393 S--PYSLYFASGSHDRTARLWSFD-RTYPLRI---YAGHLADVDCVKFHPNSNYLATGST 446
Query: 163 DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTF 222
D T LW + G F GH G V+SL+ +P+G+ S D +KLWD+ +
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Query: 223 IGHESDINAVAFFPNGYAFTTGSDDATCRLFDLR---------ADQELLMYSHDNIICGI 273
GH +I ++ F P+ + S D + R++D+R L+ + + +
Sbjct: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
Query: 274 TSVAFSRSGRLLLAGYDDFN 293
SV F LL+ G N
Sbjct: 567 LSVQFMACNLLLVTGITQEN 586
Score = 68.9 bits (167), Expect = 6e-12
Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 27/263 (10%)
Query: 84 SYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNIC-SIYSLKTRE-----GNVRVSR 137
S TT +A + T +P +A G DN C ++SL++++ V VSR
Sbjct: 255 SLTTICFYAFYNTEQLLNTAEISPDSKLLAAG-FDNSCIKLWSLRSKKLKSEPHQVDVSR 313
Query: 138 ELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197
+L+C I+ D D G + GH G V S D
Sbjct: 314 I------HLAC-------DILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFLADSS 355
Query: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRA 257
+S + D SI+ WD+ + GH + + P F +GS D T RL+
Sbjct: 356 GLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDR 415
Query: 258 DQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSC 317
L +Y+ + + V F + L G D +W A +G+ + GH V
Sbjct: 416 TYPLRIYA--GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS 473
Query: 318 LGVTDDGMAVATGSWDSFLKIWN 340
L + +G +A+ D LK+W+
Sbjct: 474 LAFSPNGKYLASAGEDQRLKLWD 496
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 102 bits (255), Expect = 4e-22
Identities = 85/339 (25%), Positives = 136/339 (40%), Gaps = 55/339 (16%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV-HAIPLRSSWVMTCAYAP- 107
T +GH + ++ W D R L S ++G++++WD T +V + S W+ ++ P
Sbjct: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
Query: 108 ----SGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163
+VA D I+ T G R R L GHT ++C R+ D + ++S D
Sbjct: 211 HANPECRYVASSSKDGSVRIWD--TTAG--RCERILTGHTQSVTCLRWGGDGLLYSASQD 266
Query: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPD---------------------------- 195
T +W G GH V +++L+ D
Sbjct: 267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELK 326
Query: 196 --------------GRTFVSGACDASIKLWD-VRDSMCRQTFIGHESDINAVAFFPNGYA 240
VSG+ D ++ LW D GH++ IN V F P+
Sbjct: 327 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRI 386
Query: 241 FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM 300
+ S D + +L+D R + L S + + +A+S RLL++G D +WD
Sbjct: 387 VASASFDKSIKLWDGRTGKYLA--SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Query: 301 KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
A L GH + V + + DG VA+G D L+IW
Sbjct: 445 AQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 85.1 bits (209), Expect = 8e-17
Identities = 77/317 (24%), Positives = 136/317 (42%), Gaps = 35/317 (11%)
Query: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101
R R +L GH + ++ + + L S S D + WD T WV+
Sbjct: 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVL 160
Query: 102 TCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSC-----------CR 150
+ +++P G +A G + ++ T + +V R L GH+ +++ CR
Sbjct: 161 SISWSPDGRKLASGCKNGQILLWDPSTGK---QVGRTLAGHSKWITGLSWEPLHANPECR 217
Query: 151 FLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKL 210
+ + +SS D + +WD G+ GH+ V L DG + S + D +IK+
Sbjct: 218 Y-----VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271
Query: 211 WDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS---DDATCRLFDLRAD-QEL--LMY 264
W D + +T GH +N +A YA TG+ +A+ DL+ QEL
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMA-LSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
Query: 265 SHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGV-LAGHDNRVSCLGVTDD 323
S N++ G + L++G DDF +W + + + GH ++ + + D
Sbjct: 331 SRYNLVRG-------QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383
Query: 324 GMAVATGSWDSFLKIWN 340
VA+ S+D +K+W+
Sbjct: 384 SRIVASASFDKSIKLWD 400
Score = 82.4 bits (202), Expect = 5e-16
Identities = 63/248 (25%), Positives = 101/248 (40%), Gaps = 41/248 (16%)
Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
R R L GH + + WG D LL SASQD + +W ++ + WV T A
Sbjct: 237 RCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 106 AP-----SGNFVAC----------GGLDNI----CSIYSLKTREGNVRVSR--------- 137
+ +G F G L + S Y+L +G R+
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355
Query: 138 -----------ELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWDIETGQQTVGFAGHSG 185
+ GH ++ F D++I+ S+ D + LWD TG+ GH
Sbjct: 356 WSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415
Query: 186 DVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGS 245
V ++ + D R VSG+ D+++K+WDV+ GH ++ AV + P+G +G
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG 475
Query: 246 DDATCRLF 253
D R++
Sbjct: 476 KDKCLRIW 483
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 102 bits (254), Expect = 5e-22
Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 9/293 (3%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
R +GH A I ++ + + L +AS D L++W+ + + V + ++P
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQII-TSSGDTTCA 167
GN +A D ++ + + G E HT + F D Q + T+S D +
Sbjct: 72 GNLLASASRDRTVRLW-IPDKRGKFS---EFKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 168 LWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHES 227
+W + + H+ V +PDGR VS + D +IK+WD + C F
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 228 DINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS-HDNIICGITSVAFSRSGRLLL 286
N V F P+G + D T +++D+R ++ L Y H G+ ++F SG L+
Sbjct: 188 FANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG---GVNCISFHPSGNYLI 244
Query: 287 AGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
D I D ++G L GH V + + G A+G D+ + +W
Sbjct: 245 TASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297
Score = 81.6 bits (200), Expect = 9e-16
Identities = 46/209 (22%), Positives = 87/209 (41%), Gaps = 5/209 (2%)
Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
+ H A + ++ + D + L +AS+D + +W Y ++++ + WV ++P G
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWD 170
+ D I+ N + G+ + F I S+G D T +WD
Sbjct: 159 IVSCSEDKTIKIWDTT----NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214
Query: 171 IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDIN 230
+ + + HSG V +S P G ++ + D ++K+ D+ + T GH +
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274
Query: 231 AVAFFPNGYAFTTGSDDATCRLFDLRADQ 259
V+F G F +G D L+ D+
Sbjct: 275 TVSFSKGGELFASGGADTQVLLWRTNFDE 303
Score = 72.8 bits (177), Expect = 4e-13
Identities = 42/161 (26%), Positives = 72/161 (44%), Gaps = 2/161 (1%)
Query: 180 FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGY 239
F GH + SL L+P+G+ + + D + LW+ + ++GH+ + +V F P+G
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 240 AFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDA 299
+ S D T RL+ D+ + SV FS G+ L +D + +W
Sbjct: 74 LLASASRDRTVRLW--IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 300 MKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
+ L H + V C + DG + + S D +KIW+
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172
Score = 69.3 bits (168), Expect = 5e-12
Identities = 42/186 (22%), Positives = 80/186 (43%), Gaps = 4/186 (2%)
Query: 156 QIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRD 215
Q+ T+S DT LW+ + + + GH V S+ +P G S + D +++LW
Sbjct: 32 QLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDK 91
Query: 216 SMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELL-MYSHDNIICGIT 274
F H + + +V F +G T S+D + +++ + + L +Y H + +
Sbjct: 92 RGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTH---WVR 148
Query: 275 SVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS 334
FS GRL+++ +D IWD + + + G +A+ D
Sbjct: 149 CAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQ 208
Query: 335 FLKIWN 340
+K+W+
Sbjct: 209 TVKVWD 214
Score = 54.3 bits (129), Expect = 2e-07
Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMY-SHDNIICGI 273
D + + F GH++ I ++ PNG T S D L++ + Y H ++ +
Sbjct: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV---V 63
Query: 274 TSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWD 333
TSV FS G LL + D +W K + H V + + DG +AT S D
Sbjct: 64 TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123
Query: 334 SFLKIWN 340
+K+W+
Sbjct: 124 KSIKVWS 130
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 100 bits (249), Expect = 2e-21
Identities = 52/197 (26%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 59 YAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLD 118
+ + + DS+ L + + GK+ I+ + K +++ R ++++ AY+P G ++A G +D
Sbjct: 110 WTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAID 169
Query: 119 NICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQI-ITSSGDTTCALWDIETGQQT 177
I +I+ + T ++ L GH + F D+Q+ +T+S D ++D++
Sbjct: 170 GIINIFDIATG----KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA 225
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
+GH+ V++++ PD FVS + D S+K+WDV C TF H+ + V + N
Sbjct: 226 GTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGN 285
Query: 238 GYAFTTGSDDATCRLFD 254
G + DD ++D
Sbjct: 286 GSKIVSVGDDQEIHIYD 302
Score = 77.4 bits (189), Expect = 2e-14
Identities = 62/279 (22%), Positives = 130/279 (46%), Gaps = 13/279 (4%)
Query: 27 DSTLTQITAGLDPVGRI------QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI 80
+++ T +T LD + ++ ++ + +L GH + ++ + S+S D +
Sbjct: 30 ENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
Query: 81 IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELP 140
+WD ++ +I T A++P ++A G +I+ +++ G S +
Sbjct: 90 LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES--GKKEYSLDTR 147
Query: 141 GHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFV 200
G LS D + + + D ++DI TG+ GH+ + SL+ +PD + V
Sbjct: 148 GKF-ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
Query: 201 SGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE 260
+ + D IK++DV+ + T GH S + VAF P+ F + S D + +++D+
Sbjct: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC 266
Query: 261 L-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
+ + H + + G V ++ +G +++ DD +I+D
Sbjct: 267 VHTFFDHQDQVWG---VKYNGNGSKIVSVGDDQEIHIYD 302
Score = 76.3 bits (186), Expect = 4e-14
Identities = 55/230 (23%), Positives = 99/230 (43%), Gaps = 5/230 (2%)
Query: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWD 170
V G LD++ ++ K R+ + + L GH + I SS D LWD
Sbjct: 35 VVTGSLDDLVKVW--KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Query: 171 IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDIN 230
+E G+Q D +L+ +PD + +G + ++ V + I
Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL 152
Query: 231 AVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYD 290
++A+ P+G +G+ D +FD+ + L+++ + I S+ FS +LL+ D
Sbjct: 153 SIAYSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASD 210
Query: 291 DFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
D I+D + AG L+GH + V + D + S D +K+W+
Sbjct: 211 DGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 98.6 bits (244), Expect = 7e-21
Identities = 70/241 (29%), Positives = 101/241 (41%), Gaps = 42/241 (17%)
Query: 141 GHTGYLS-CCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTF 199
GHT +LS CC +++ TSSGDTT LWD+ G + F GHS V S + G
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
Query: 200 VSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD- 258
S + D + K+WDV CR T GH +N++ FFP T S D T ++D R
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
Query: 259 QELLMYSHDNII-----------------CGIT----------------------SVAFS 279
E +Y H + I CG+T V F
Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Query: 280 RSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
SGR+L + ++ D +K L GH+N + + DG + +G D ++ W
Sbjct: 572 SSGRVLAQASGNGVIHLLD-LKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Query: 340 N 340
+
Sbjct: 631 S 631
Score = 82.0 bits (201), Expect = 7e-16
Identities = 72/282 (25%), Positives = 111/282 (39%), Gaps = 18/282 (6%)
Query: 19 RDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGK 78
+D +CG+ L ++ +G + T GH + + L ++S D
Sbjct: 364 KDILVSCGEDRLWKV------LGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTT 417
Query: 79 LIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRE 138
+ +WD + + S V +C + GNFVA LD I+ + + R
Sbjct: 418 VKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE----RCRCT 473
Query: 139 LPGHTGYLSCCRFLD-DNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197
L GHT ++ F N ++TSS D T ++WD TG GH + P G
Sbjct: 474 LYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGH 533
Query: 198 TFVSGACDAS--IKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDL 255
S CDA KLWD R + + S N V F +G S + L DL
Sbjct: 534 MIAS--CDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591
Query: 256 RADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIW 297
++ + + H+N +V FS G +L +G D W
Sbjct: 592 KSGEIHKLMGHEN---EAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 45.4 bits (106), Expect = 7e-05
Identities = 41/162 (25%), Positives = 60/162 (37%), Gaps = 4/162 (2%)
Query: 180 FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGY 239
F H V +S+ P VS D K+ + T GH ++ F P+G
Sbjct: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
Query: 240 AFTTGSDDATCRLFDL-RADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWD 298
T S D T +L+DL + D L H + S + G + + D IWD
Sbjct: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSR---AVWSCTWHSCGNFVASSSLDKTSKIWD 464
Query: 299 AMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
L GH + V+ + + T S D L IW+
Sbjct: 465 VNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD 506
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVM 188
R G ++ + L GH ++ C N+I++ S D T +W TG+ GH+G V
Sbjct: 248 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 307
Query: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
S + + +SG+ D ++K+W+ C T GH S + + +GS DA
Sbjct: 308 SSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 363
Query: 249 TCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGV 307
T R++D+ Q L ++ H + + V + GR +++G DF +WD
Sbjct: 364 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 419 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Score = 88.6 bits (218), Expect = 7e-18
Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
V+TC GN + G DN ++S T + R L GHTG + + + DN II+
Sbjct: 265 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 318
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
S D T +W+ ETG+ GH+ V + L + VSG+ DA++++WD+ C
Sbjct: 319 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 376
Query: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAF 278
+GH + + V + +G +G+ D +++D + L + H N + S+ F
Sbjct: 377 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 431
Query: 279 SRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
G +++G D + +WD G+ L GH + S + + D+ + +G+ DS +KI
Sbjct: 432 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 487
Query: 339 WN 340
W+
Sbjct: 488 WD 489
Score = 85.9 bits (211), Expect = 5e-17
Identities = 66/258 (25%), Positives = 119/258 (46%), Gaps = 20/258 (7%)
Query: 49 RTLRGHLAKIYAMHWGTDSR--LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 106
RTL GH + W + R +++S S D L +W++ T +H + +S V C +
Sbjct: 297 RTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHL 351
Query: 107 PSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTC 166
V+ G D ++ ++T + L GH + C ++ D ++++ + D
Sbjct: 352 HEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMV 405
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHE 226
+WD ET GH+ V SL DG VSG+ D SI++WDV C T GH+
Sbjct: 406 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 463
Query: 227 SDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLL 285
S + + N +G+ D+T +++D++ Q L + + +T + F+++ +
Sbjct: 464 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FV 519
Query: 286 LAGYDDFNCNIWDAMKGD 303
+ DD +WD G+
Sbjct: 520 ITSSDDGTVKLWDLKTGE 537
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVM 188
R G ++ + L GH ++ C N+I++ S D T +W TG+ GH+G V
Sbjct: 366 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 425
Query: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
S + + +SG+ D ++K+W+ C T GH S + + +GS DA
Sbjct: 426 SSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 481
Query: 249 TCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGV 307
T R++D+ Q L ++ H + + V + GR +++G DF +WD
Sbjct: 482 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 537 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Score = 88.6 bits (218), Expect = 7e-18
Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
V+TC GN + G DN ++S T + R L GHTG + + + DN II+
Sbjct: 383 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 436
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
S D T +W+ ETG+ GH+ V + L + VSG+ DA++++WD+ C
Sbjct: 437 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 494
Query: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAF 278
+GH + + V + +G +G+ D +++D + L + H N + S+ F
Sbjct: 495 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 549
Query: 279 SRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
G +++G D + +WD G+ L GH + S + + D+ + +G+ DS +KI
Sbjct: 550 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 605
Query: 339 WN 340
W+
Sbjct: 606 WD 607
Score = 85.9 bits (211), Expect = 5e-17
Identities = 66/258 (25%), Positives = 119/258 (46%), Gaps = 20/258 (7%)
Query: 49 RTLRGHLAKIYAMHWGTDSR--LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 106
RTL GH + W + R +++S S D L +W++ T +H + +S V C +
Sbjct: 415 RTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHL 469
Query: 107 PSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTC 166
V+ G D ++ ++T + L GH + C ++ D ++++ + D
Sbjct: 470 HEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMV 523
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHE 226
+WD ET GH+ V SL DG VSG+ D SI++WDV C T GH+
Sbjct: 524 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 581
Query: 227 SDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLL 285
S + + N +G+ D+T +++D++ Q L + + +T + F+++ +
Sbjct: 582 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FV 637
Query: 286 LAGYDDFNCNIWDAMKGD 303
+ DD +WD G+
Sbjct: 638 ITSSDDGTVKLWDLKTGE 655
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 97.1 bits (240), Expect = 2e-20
Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 12/213 (5%)
Query: 129 REGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVM 188
R G ++ + L GH ++ C N+I++ S D T +W TG+ GH+G V
Sbjct: 286 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW 345
Query: 189 SLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDA 248
S + + +SG+ D ++K+W+ C T GH S + + +GS DA
Sbjct: 346 SSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDA 401
Query: 249 TCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGV 307
T R++D+ Q L ++ H + + V + GR +++G DF +WD
Sbjct: 402 TLRVWDIETGQCLHVLMGH---VAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 308 LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
L GH NRV L DG+ V +GS D+ +++W+
Sbjct: 457 LQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Score = 88.6 bits (218), Expect = 7e-18
Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 100 VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIIT 159
V+TC GN + G DN ++S T + R L GHTG + + + DN II+
Sbjct: 303 VITCLQF-CGNRIVSGSDDNTLKVWSAVTG----KCLRTLVGHTGGVWSSQ-MRDNIIIS 356
Query: 160 SSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
S D T +W+ ETG+ GH+ V + L + VSG+ DA++++WD+ C
Sbjct: 357 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCL 414
Query: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAF 278
+GH + + V + +G +G+ D +++D + L + H N + S+ F
Sbjct: 415 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN---RVYSLQF 469
Query: 279 SRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
G +++G D + +WD G+ L GH + S + + D+ + +G+ DS +KI
Sbjct: 470 D--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKI 525
Query: 339 WN 340
W+
Sbjct: 526 WD 527
Score = 85.9 bits (211), Expect = 5e-17
Identities = 66/258 (25%), Positives = 119/258 (46%), Gaps = 20/258 (7%)
Query: 49 RTLRGHLAKIYAMHWGTDSR--LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYA 106
RTL GH + W + R +++S S D L +W++ T +H + +S V C +
Sbjct: 335 RTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR-CMHL 389
Query: 107 PSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTC 166
V+ G D ++ ++T + L GH + C ++ D ++++ + D
Sbjct: 390 HEKRVVS-GSRDATLRVWDIETGQ----CLHVLMGHVAAVRCVQY-DGRRVVSGAYDFMV 443
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHE 226
+WD ET GH+ V SL DG VSG+ D SI++WDV C T GH+
Sbjct: 444 KVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ 501
Query: 227 SDINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL-LMYSHDNIICGITSVAFSRSGRLL 285
S + + N +G+ D+T +++D++ Q L + + +T + F+++ +
Sbjct: 502 SLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FV 557
Query: 286 LAGYDDFNCNIWDAMKGD 303
+ DD +WD G+
Sbjct: 558 ITSSDDGTVKLWDLKTGE 575
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 97.1 bits (240), Expect = 2e-20
Identities = 66/265 (24%), Positives = 109/265 (41%), Gaps = 7/265 (2%)
Query: 76 DGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRV 135
D L++W ++ + V ++PSG+ +A G D I+ + +G V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
Query: 136 SRELPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAP 194
R HT + F D Q +T+S D T +W + + H V +P
Sbjct: 61 FR---AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
Query: 195 DGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFD 254
DGR VS + D ++KLWD C ++ H + V F P+G D T +++D
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 255 LRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNR 314
+R + L Y + + ++F SG L+ D I D M+G L GH
Sbjct: 178 VRTHRLLQHYQLHS--AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGP 235
Query: 315 VSCLGVTDDGMAVATGSWDSFLKIW 339
+ + + G A+G D + +W
Sbjct: 236 ATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 94.7 bits (234), Expect = 1e-19
Identities = 60/246 (24%), Positives = 107/246 (43%), Gaps = 7/246 (2%)
Query: 53 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFV 112
GH + +++ LL S S+D + IW + ++ V + + G
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 113 ACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTCALWDI 171
D +++ ++ +S+ H ++ C +F D ++I S S D T LWD
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 172 ETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINA 231
+ + + H G V + P G + D ++K+WDVR Q + H + +N
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
Query: 232 VAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDD 291
++F P+G T S D+T ++ DL + L+Y+ T+VAFSR+G +G D
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGR--LLYTLHGHQGPATTVAFSRTGEYFASGGSD 254
Query: 292 FNCNIW 297
+W
Sbjct: 255 EQVMVW 260
Score = 84.7 bits (208), Expect = 1e-16
Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 5/197 (2%)
Query: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
R H A + ++H+ +D + V+AS D + +W ++ + ++ +WV ++P G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG-DTTCALWD 170
+ D ++ +RE H G+++ F I ++G D T +WD
Sbjct: 122 IVSASDDKTVKLWDKSSRE----CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 171 IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDIN 230
+ T + + HS V LS P G ++ + D+++K+ D+ + T GH+
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 231 AVAFFPNGYAFTTGSDD 247
VAF G F +G D
Sbjct: 238 TVAFSRTGEYFASGGSD 254
Score = 77.4 bits (189), Expect = 2e-14
Identities = 41/178 (23%), Positives = 79/178 (44%), Gaps = 2/178 (1%)
Query: 163 DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTF 222
D+ +W ++ + F GH V ++ +P G SG+ D ++++W F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 223 IGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSG 282
H + + +V F +G +F T SDD T +++ ++ ++S I + FS G
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 283 RLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
RL+++ DD +WD + H V+ + G +A D+ +K+W+
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Score = 75.1 bits (183), Expect = 8e-14
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 5/163 (3%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
+L H+ + + D RL+VSAS D + +WD + VH+ +V + PSG
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
Query: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTTCAL 168
+A G+DN ++ ++T R+ + H+ ++ F N +IT+S D+T +
Sbjct: 162 TCIAAAGMDNTVKVWDVRTH----RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLW 211
D+ G+ GH G +++ + G F SG D + +W
Sbjct: 218 LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 95.5 bits (236), Expect = 6e-20
Identities = 82/313 (26%), Positives = 135/313 (43%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKV---------HAIPL 95
LRGH ++++ W S LL S S D IW+ +T V H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR 214
+ S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLG 347
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD---QELLMYSHD--NI 269
+TF GH +++NA+ + P+G + SDD T +++ ++ D +L +S + I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 270 ICGITSVAFSR--SGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLKIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/261 (22%), Positives = 112/261 (42%), Gaps = 22/261 (8%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 110 NFVACGG--LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTC 166
F +C ++C R G + GHT ++ ++ ++ S S D T
Sbjct: 331 TFASCSTDMCIHVC-------RLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRT---------FVSGACDASIKLWDVRDSM 217
+W ++ HS ++ ++ +P G S + D++++LWDV +
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 218 CRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVA 277
C T + H+ + +VAF P+G +GS D +++ ++ L++S+ GI V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS--LVHSYQG-TGGIFEVC 500
Query: 278 FSRSGRLLLAGYDDFNCNIWD 298
++ G + A D + + D
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/254 (22%), Positives = 102/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W +D LL S DG IW N + + + GN+V G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G A + S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNIWDAMKG 302
D +IW+ G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 59.7 bits (143), Expect = 4e-09
Identities = 47/207 (22%), Positives = 78/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW VH + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
WD+E G T H V S++ +PDG+ SG+ D + +W+ + ++ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVAFFPNGYAFTTGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 28.5 bits (62), Expect = 9.0
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
++A VL GH++ V +A+GS DS +IWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 95.5 bits (236), Expect = 6e-20
Identities = 82/313 (26%), Positives = 135/313 (43%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKV---------HAIPL 95
LRGH ++++ W S LL S S D IW+ +T V H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR 214
+ S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLG 347
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD---QELLMYSHD--NI 269
+TF GH +++NA+ + P+G + SDD T +++ ++ D +L +S + I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 270 ICGITSVAFSR--SGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLKIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/261 (22%), Positives = 112/261 (42%), Gaps = 22/261 (8%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 110 NFVACGG--LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTC 166
F +C ++C R G + GHT ++ ++ ++ S S D T
Sbjct: 331 TFASCSTDMCIHVC-------RLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRT---------FVSGACDASIKLWDVRDSM 217
+W ++ HS ++ ++ +P G S + D++++LWDV +
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 218 CRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVA 277
C T + H+ + +VAF P+G +GS D +++ ++ L++S+ GI V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS--LVHSYQG-TGGIFEVC 500
Query: 278 FSRSGRLLLAGYDDFNCNIWD 298
++ G + A D + + D
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/254 (22%), Positives = 102/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W +D LL S DG IW N + + + GN+V G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G A + S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNIWDAMKG 302
D +IW+ G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 59.7 bits (143), Expect = 4e-09
Identities = 47/207 (22%), Positives = 78/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW VH + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
WD+E G T H V S++ +PDG+ SG+ D + +W+ + ++ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVAFFPNGYAFTTGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 28.5 bits (62), Expect = 9.0
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
++A VL GH++ V +A+GS DS +IWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 95.5 bits (236), Expect = 6e-20
Identities = 82/313 (26%), Positives = 135/313 (43%), Gaps = 30/313 (9%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKV---------HAIPL 95
LRGH ++++ W S LL S S D IW+ +T V H +P
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
V + + G +A G D I+ T GN+ + L H G + ++
Sbjct: 235 NKD-VTSLDWNSDGTLLAMGSYDGFARIW---TENGNL--ASTLGQHKGPIFALKWNKKG 288
Query: 156 QIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR 214
+ S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 289 NYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLG 347
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD---QELLMYSHD--NI 269
+TF GH +++NA+ + P+G + SDD T +++ ++ D +L +S + I
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTI 407
Query: 270 ICGITSVAFSR--SGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAV 327
T A S S +L + D +WD +G L H V + + DG +
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 328 ATGSWDSFLKIWN 340
A+GS+D ++ IWN
Sbjct: 468 ASGSFDKYVHIWN 480
Score = 80.9 bits (198), Expect = 2e-15
Identities = 59/261 (22%), Positives = 112/261 (42%), Gaps = 22/261 (8%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 271 TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNM 330
Query: 110 NFVACGG--LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTC 166
F +C ++C R G + GHT ++ ++ ++ S S D T
Sbjct: 331 TFASCSTDMCIHVC-------RLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 383
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRT---------FVSGACDASIKLWDVRDSM 217
+W ++ HS ++ ++ +P G S + D++++LWDV +
Sbjct: 384 KIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGV 443
Query: 218 CRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVA 277
C T + H+ + +VAF P+G +GS D +++ ++ L++S+ GI V
Sbjct: 444 CTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGS--LVHSYQG-TGGIFEVC 500
Query: 278 FSRSGRLLLAGYDDFNCNIWD 298
++ G + A D + + D
Sbjct: 501 WNARGDKVGASASDGSVCVLD 521
Score = 74.3 bits (181), Expect = 1e-13
Identities = 57/254 (22%), Positives = 102/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W +D LL S DG IW N + + + GN+V G+
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWNKKGNYVLSAGV 296
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + ++ + S D + +
Sbjct: 297 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV 352
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ C H +I + + P
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 238 GYA---------FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G A + S D+T RL+D+ +Q + ++ + SVAFS G+ L +G
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDV--EQGVCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 289 YDDFNCNIWDAMKG 302
D +IW+ G
Sbjct: 471 SFDKYVHIWNTQSG 484
Score = 59.7 bits (143), Expect = 4e-09
Identities = 47/207 (22%), Positives = 78/207 (37%), Gaps = 37/207 (17%)
Query: 49 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
+T +GH ++ A+ W LL S S D L IW VH + S + T ++P+
Sbjct: 353 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412
Query: 109 GNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCAL 168
G T N + + ++S D+T L
Sbjct: 413 GP----------------ATSNPNSSI--------------------MLASASFDSTVRL 436
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESD 228
WD+E G T H V S++ +PDG+ SG+ D + +W+ + ++ G
Sbjct: 437 WDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGG 495
Query: 229 INAVAFFPNGYAFTTGSDDATCRLFDL 255
I V + G + D + + DL
Sbjct: 496 IFEVCWNARGDKVGASASDGSVCVLDL 522
Score = 28.5 bits (62), Expect = 9.0
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
++A VL GH++ V +A+GS DS +IWN
Sbjct: 170 NKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 207
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 94.7 bits (234), Expect = 1e-19
Identities = 82/315 (26%), Positives = 138/315 (43%), Gaps = 34/315 (10%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKVHAIPLRSSW----- 99
LRGH ++++ W S LL S S D IW+ S +T V +R
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 100 ---VMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQ 156
V + + G +A G D I+ T++GN+ + L H G + ++
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIW---TKDGNL--ASTLGQHKGPIFALKWNKKGN 279
Query: 157 IITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRD 215
I S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQ 338
Query: 216 SMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELL-MYSHDNIICGIT 274
+TF GH +++NA+ + P G + SDD T +++ ++ D + + +H+ I
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK---EIY 395
Query: 275 SVAFSRSG--------RLLLAGYD-DFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
++ +S +G L+LA D +WD +G L H V + + DG
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGR 455
Query: 326 AVATGSWDSFLKIWN 340
+A+GS+D + IWN
Sbjct: 456 YLASGSFDKCVHIWN 470
Score = 83.2 bits (204), Expect = 3e-16
Identities = 60/262 (22%), Positives = 112/262 (42%), Gaps = 18/262 (6%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 261 TLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN 320
Query: 110 NFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTCAL 168
F +C ++C I+ K G R + GHT ++ ++ ++ S S D T +
Sbjct: 321 TFASCS--TDMC-IHVCKL--GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375
Query: 169 WDIETGQQTVGFAGHSGDVMSLSLAPDG---------RTFVSGACDASIKLWDVRDSMCR 219
W ++ H+ ++ ++ +P G S + D++++LWDV +C
Sbjct: 376 WSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICI 435
Query: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFS 279
T H+ + +VAF P+G +GS D +++ + + Y GI V ++
Sbjct: 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG---GIFEVCWN 492
Query: 280 RSGRLLLAGYDDFNCNIWDAMK 301
+G + A D + + D K
Sbjct: 493 AAGDKVGASASDGSVCVLDLRK 514
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/254 (22%), Positives = 104/254 (40%), Gaps = 16/254 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W ++ LL + S DG IW N + + + GNF+ G+
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + +N + S D + + +
Sbjct: 287 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPI 342
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ C H +I + + P
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Query: 238 G---------YAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G + S D+T RL+D+ D+ + +++ + SVAFS GR L +G
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDV--DRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
Query: 289 YDDFNCNIWDAMKG 302
D +IW+ G
Sbjct: 461 SFDKCVHIWNTQTG 474
Score = 62.0 bits (149), Expect = 7e-10
Identities = 49/213 (23%), Positives = 81/213 (38%), Gaps = 37/213 (17%)
Query: 44 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103
Q R +T +GH ++ A+ W LL S S D L IW N VH + + + T
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTI 397
Query: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163
++P+G T N + + ++S D
Sbjct: 398 KWSPTGP----------------GTNNPNANL--------------------MLASASFD 421
Query: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFI 223
+T LWD++ G H V S++ +PDGR SG+ D + +W+ + ++
Sbjct: 422 STVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481
Query: 224 GHESDINAVAFFPNGYAFTTGSDDATCRLFDLR 256
G I V + G + D + + DLR
Sbjct: 482 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
Score = 35.0 bits (79), Expect = 0.096
Identities = 29/142 (20%), Positives = 57/142 (40%), Gaps = 17/142 (11%)
Query: 176 QTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRD---SMCRQTFIGH------- 225
+ V GH +V + P SG+ D++ ++W++ + S Q + H
Sbjct: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
Query: 226 ----ESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRS 281
D+ ++ + G TGS D R++ + + H I ++ +++
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKG---PIFALKWNKK 277
Query: 282 GRLLLAGYDDFNCNIWDAMKGD 303
G +L+ D IWDA G+
Sbjct: 278 GNFILSAGVDKTTIIWDAHTGE 299
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 94.7 bits (234), Expect = 1e-19
Identities = 84/315 (26%), Positives = 139/315 (44%), Gaps = 34/315 (10%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKV---------HAIPL 95
LRGH ++++ W S LL S S D IW+ +T V H +P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
V + + +G +A G D I+ T +GN+ + L H G + ++
Sbjct: 237 NKD-VTSLDWNTNGTLLATGSYDGFARIW---TEDGNL--ASTLGQHKGPIFALKWNRKG 290
Query: 156 QIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR 214
I S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 291 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLG 349
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMY---SHDNIIC 271
+TF GH +++NA+ + P+G + SDD T +++ ++ QE+ ++ +H+ I
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIY 407
Query: 272 GI----TSVAFSR--SGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
I T A S S +L + D +WD +G L H V + + DG
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467
Query: 326 AVATGSWDSFLKIWN 340
+A+GS+D + IWN
Sbjct: 468 YLASGSFDKCVHIWN 482
Score = 80.5 bits (197), Expect = 2e-15
Identities = 58/264 (21%), Positives = 110/264 (41%), Gaps = 22/264 (8%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 110 NFVACGG--LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTC 166
F +C ++C R G R + GHT ++ ++ ++ S S D T
Sbjct: 333 TFASCSTDMCIHVC-------RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRT---------FVSGACDASIKLWDVRDSM 217
+W ++ H+ ++ ++ +P G S + D++++LWD+ +
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 218 CRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVA 277
C T H+ + +VAF P+G +GS D +++ ++ + Y GI V
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFEVC 502
Query: 278 FSRSGRLLLAGYDDFNCNIWDAMK 301
++ G + A D + + D K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526
Score = 75.1 bits (183), Expect = 8e-14
Identities = 55/255 (21%), Positives = 106/255 (41%), Gaps = 16/255 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W T+ LL + S DG IW N + + + GN++ G+
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + ++ + S D + + +
Sbjct: 299 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPV 354
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ +C H +I + + P
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 238 GYA---------FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G A + S D+T RL+D+ ++ + ++ + SVAFS G+ L +G
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 289 YDDFNCNIWDAMKGD 303
D +IW+ G+
Sbjct: 473 SFDKCVHIWNTQSGN 487
Score = 61.2 bits (147), Expect = 1e-09
Identities = 48/211 (22%), Positives = 80/211 (37%), Gaps = 37/211 (17%)
Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
R +T +GH ++ A+ W LL S S D L IW +H + + + T +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 106 APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTT 165
+P+G T N + + ++S D+T
Sbjct: 412 SPTGP----------------ATSNPNSNI--------------------MLASASFDST 435
Query: 166 CALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGH 225
LWDIE G T H V S++ +PDG+ SG+ D + +W+ + ++ G
Sbjct: 436 VRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG- 494
Query: 226 ESDINAVAFFPNGYAFTTGSDDATCRLFDLR 256
I V + G + D + + DLR
Sbjct: 495 TGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 94.7 bits (234), Expect = 1e-19
Identities = 84/315 (26%), Positives = 139/315 (44%), Gaps = 34/315 (10%)
Query: 51 LRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD------SYTTNKV---------HAIPL 95
LRGH ++++ W S LL S S D IW+ +T V H +P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 96 RSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
V + + +G +A G D I+ T +GN+ + L H G + ++
Sbjct: 237 NKD-VTSLDWNTNGTLLATGSYDGFARIW---TEDGNL--ASTLGQHKGPIFALKWNRKG 290
Query: 156 QIITSSG-DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVR 214
I S+G D T +WD TG+ F HS + + + TF S + D I + +
Sbjct: 291 NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLG 349
Query: 215 DSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMY---SHDNIIC 271
+TF GH +++NA+ + P+G + SDD T +++ ++ QE+ ++ +H+ I
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK--QEVCIHDLQAHNKEIY 407
Query: 272 GI----TSVAFSR--SGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGM 325
I T A S S +L + D +WD +G L H V + + DG
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467
Query: 326 AVATGSWDSFLKIWN 340
+A+GS+D + IWN
Sbjct: 468 YLASGSFDKCVHIWN 482
Score = 80.5 bits (197), Expect = 2e-15
Identities = 58/264 (21%), Positives = 110/264 (41%), Gaps = 22/264 (8%)
Query: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
TL H I+A+ W ++SA D IIWD++T P S+ + + +
Sbjct: 273 TLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT 332
Query: 110 NFVACGG--LDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS-SGDTTC 166
F +C ++C R G R + GHT ++ ++ ++ S S D T
Sbjct: 333 TFASCSTDMCIHVC-------RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTL 385
Query: 167 ALWDIETGQQTVGFAGHSGDVMSLSLAPDGRT---------FVSGACDASIKLWDVRDSM 217
+W ++ H+ ++ ++ +P G S + D++++LWD+ +
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGV 445
Query: 218 CRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVA 277
C T H+ + +VAF P+G +GS D +++ ++ + Y GI V
Sbjct: 446 CTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFEVC 502
Query: 278 FSRSGRLLLAGYDDFNCNIWDAMK 301
++ G + A D + + D K
Sbjct: 503 WNARGDKVGASASDGSVCVLDLRK 526
Score = 75.1 bits (183), Expect = 8e-14
Identities = 55/255 (21%), Positives = 106/255 (41%), Gaps = 16/255 (6%)
Query: 58 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGL 117
+ ++ W T+ LL + S DG IW N + + + GN++ G+
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGV 298
Query: 118 DNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQT 177
D I+ T E ++ P H+ + ++ + S D + + +
Sbjct: 299 DKTTIIWDAHTGEAK----QQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPV 354
Query: 178 VGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPN 237
F GH+ +V ++ P G S + D ++K+W ++ +C H +I + + P
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 238 GYA---------FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAG 288
G A + S D+T RL+D+ ++ + ++ + SVAFS G+ L +G
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVAFSPDGKYLASG 472
Query: 289 YDDFNCNIWDAMKGD 303
D +IW+ G+
Sbjct: 473 SFDKCVHIWNTQSGN 487
Score = 61.2 bits (147), Expect = 1e-09
Identities = 48/211 (22%), Positives = 80/211 (37%), Gaps = 37/211 (17%)
Query: 46 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 105
R +T +GH ++ A+ W LL S S D L IW +H + + + T +
Sbjct: 352 RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKW 411
Query: 106 APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTT 165
+P+G T N + + ++S D+T
Sbjct: 412 SPTGP----------------ATSNPNSNI--------------------MLASASFDST 435
Query: 166 CALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGH 225
LWDIE G T H V S++ +PDG+ SG+ D + +W+ + ++ G
Sbjct: 436 VRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG- 494
Query: 226 ESDINAVAFFPNGYAFTTGSDDATCRLFDLR 256
I V + G + D + + DLR
Sbjct: 495 TGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,681,505
Number of Sequences: 37866
Number of extensions: 532581
Number of successful extensions: 4598
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 238
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 1425
Number of HSP's gapped (non-prelim): 1542
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.