Search of human proteins with 19923315

Search of human proteins with 19923315

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial)
[Homo sapiens]
         (504 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [H...  1008   0.0  
gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform ...   614   e-176
gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform ...   536   e-152
gi|13027630 DiGeorge syndrome critical region protein 14 [Homo s...    30   5.1  
gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger), ...    29   8.8  

>gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [Homo
           sapiens]
          Length = 504

 Score = 1008 bits (2607), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL 60
           MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL
Sbjct: 1   MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELL 60

Query: 61  QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ 120
           QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ
Sbjct: 61  QREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQ 120

Query: 121 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV 180
           RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
Sbjct: 121 RRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV 180

Query: 181 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV 240
           KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV
Sbjct: 181 KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREV 240

Query: 241 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD 300
           CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD
Sbjct: 241 CDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVD 300

Query: 301 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA 360
           PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
Sbjct: 301 PKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA 360

Query: 361 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT 420
           MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT
Sbjct: 361 MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAIT 420

Query: 421 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ 480
           PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ
Sbjct: 421 PGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQ 480

Query: 481 RLANLRQRVEQFARAFPMPGFDEH 504
           RLANLRQRVEQFARAFPMPGFDEH
Sbjct: 481 RLANLRQRVEQFARAFPMPGFDEH 504


>gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform 1
           [Homo sapiens]
          Length = 483

 Score =  614 bits (1584), Expect = e-176
 Identities = 304/460 (66%), Positives = 366/460 (79%), Gaps = 4/460 (0%)

Query: 47  ESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYY 106
           + L DSD E++ ++++E +RQ  GLELIASENF SRA LEALGSCLNNKYSEGYPG+RYY
Sbjct: 24  QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYY 83

Query: 107 GGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDL 166
           GG E +DE+E LCQ+RAL+A+ LDP  WGVNVQPYSGSPAN AVYTAL++PH RIMGLDL
Sbjct: 84  GGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDL 143

Query: 167 PDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTS 226
           PDGGHLTHG+M+D K+ISATSIFFESMPYK+NP TG I+Y+QL   ARLF P+LIIAGTS
Sbjct: 144 PDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTS 203

Query: 227 AYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGAR 286
            Y+R ++YAR+R++ DE  A+L+ADMAHISGLVAA V+PSPF+H  +VTTTTHKTLRG R
Sbjct: 204 CYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCR 263

Query: 287 SGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPM 346
           +G+IFYRKGVK+VDPKTG+EI Y  E  IN AVFP LQGGPHNHAIA VAVALKQA T  
Sbjct: 264 AGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLE 323

Query: 347 FREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSIT 406
           F+ Y  QV+ N RA+++AL E GY +V+GG+DNHL+LVDLR KG DG RAE+VLE  SI 
Sbjct: 324 FKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIA 383

Query: 407 ANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKT---A 463
            NKNTCPGDRSA+ P GLRLG PALTSR   E DF++V  FI  G+ + L+++S T   A
Sbjct: 384 CNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRA 443

Query: 464 KLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDE 503
            L++FK  L  D   +   A LR+ VE FA  FP+PG  +
Sbjct: 444 TLKEFKERLAGDKYQAAVQA-LREEVESFASLFPLPGLPD 482


>gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform 2
           [Homo sapiens]
          Length = 444

 Score =  536 bits (1382), Expect = e-152
 Identities = 275/460 (59%), Positives = 335/460 (72%), Gaps = 43/460 (9%)

Query: 47  ESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYY 106
           + L DSD E++ ++++E +RQ  GLELIASENF SRA LEALGSCLNNKYSEGYPG+RYY
Sbjct: 24  QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYY 83

Query: 107 GGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDL 166
           GG E +DE+E LCQ+RAL+A+ LDP  WGVNVQPYSGSPAN AVYTAL++PH RIMGLDL
Sbjct: 84  GGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDL 143

Query: 167 PDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTS 226
           PDGGHLTHG+M+D K+ISATSIFFESMPYK+NP TG I+Y+QL   ARLF P+LIIAGTS
Sbjct: 144 PDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTS 203

Query: 227 AYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGAR 286
            Y+R ++YAR+R++ DE  A+L+ADMAHISGLVAA V+PSPF+H  +VTTTTHKTLRG R
Sbjct: 204 CYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCR 263

Query: 287 SGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPM 346
           +G+IFYRKG                                       VAVALKQA T  
Sbjct: 264 AGMIFYRKG---------------------------------------VAVALKQAMTLE 284

Query: 347 FREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSIT 406
           F+ Y  QV+ N RA+++AL E GY +V+GG+DNHL+LVDLR KG DG RAE+VLE  SI 
Sbjct: 285 FKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIA 344

Query: 407 ANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKT---A 463
            NKNTCPGDRSA+ P GLRLG PALTSR   E DF++V  FI  G+ + L+++S T   A
Sbjct: 345 CNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRA 404

Query: 464 KLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDE 503
            L++FK  L  D   +   A LR+ VE FA  FP+PG  +
Sbjct: 405 TLKEFKERLAGDKYQAAVQA-LREEVESFASLFPLPGLPD 443


>gi|13027630 DiGeorge syndrome critical region protein 14 [Homo
           sapiens]
          Length = 476

 Score = 30.0 bits (66), Expect = 5.1
 Identities = 18/43 (41%), Positives = 23/43 (53%)

Query: 383 LVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLR 425
           L  L PKGL  A +  +  LVS TA+K T    R++ TP   R
Sbjct: 382 LASLTPKGLSPAMSPALQRLVSRTASKYTDRALRASYTPSPAR 424


>gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger),
           isoform 5 [Homo sapiens]
          Length = 896

 Score = 29.3 bits (64), Expect = 8.8
 Identities = 32/108 (29%), Positives = 45/108 (41%), Gaps = 21/108 (19%)

Query: 202 GLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAA 261
           GL+    LALT R  +   II     +  L+ YA          A+L A+MA +S ++A 
Sbjct: 258 GLVFAFLLALTTRFTKRVRIIEPLLVF--LLAYA----------AYLTAEMASLSAILAV 305

Query: 262 --------KVIPSPFKHADIVTTT-THKTLRGARSGLIFYRKGVKAVD 300
                   K + +   H    T   T KTL      +IF   G+ AVD
Sbjct: 306 TMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVD 353


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,572,666
Number of Sequences: 37866
Number of extensions: 798676
Number of successful extensions: 1620
Number of sequences better than 10.0: 5
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1613
Number of HSP's gapped (non-prelim): 5
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.