Search of human proteins with 19913371

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
         (514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...  1054   0.0  
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         943   0.0  
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         943   0.0  
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         943   0.0  
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           943   0.0  
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    916   0.0  
gi|19913365 transducin beta-like 1Y [Homo sapiens]                    916   0.0  
gi|15150805 transducin beta-like 1Y [Homo sapiens]                    916   0.0  
gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo ...   226   5e-59
gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo ...   226   5e-59
gi|239754401 PREDICTED: similar to transducin (beta)-like 1 X-li...   163   3e-40
gi|32189425 WD repeat domain 69 [Homo sapiens]                        139   6e-33
gi|26665869 WD repeat domain 51B [Homo sapiens]                       134   3e-31
gi|16554629 WD repeat domain 5 [Homo sapiens]                         127   3e-29
gi|16554627 WD repeat domain 5 [Homo sapiens]                         127   3e-29
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           125   7e-29
gi|23199987 WD repeat domain 5B [Homo sapiens]                        124   2e-28
gi|4757988 WD repeat domain 39 [Homo sapiens]                         124   2e-28
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    123   3e-28
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]              120   2e-27
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]              120   2e-27
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            117   3e-26
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            117   3e-26
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   116   6e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   114   2e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   114   2e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   114   2e-25
gi|113865883 WD repeat domain 38 [Homo sapiens]                       110   3e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            106   6e-23
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   106   6e-23

>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 1054 bits (2725), Expect = 0.0
 Identities = 514/514 (100%), Positives = 514/514 (100%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV
Sbjct: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQ 120
           EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQ
Sbjct: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQ 120

Query: 121 QGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV 180
           QGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV
Sbjct: 121 QGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPV 180

Query: 181 SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL 240
           SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL
Sbjct: 181 SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL 240

Query: 241 ATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEA 300
           ATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEA
Sbjct: 241 ATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEA 300

Query: 301 KQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPT 360
           KQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPT
Sbjct: 301 KQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPT 360

Query: 361 GNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF 420
           GNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF
Sbjct: 361 GNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF 420

Query: 421 DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSY 480
           DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSY
Sbjct: 421 DSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSY 480

Query: 481 RGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
           RGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
Sbjct: 481 RGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  943 bits (2437), Expect = 0.0
 Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118
           EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA   
Sbjct: 61  EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120

Query: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167
                      S Q  +KN E T NGEEN AH++ NNH   ME+DG+VEIP +KA VLRG
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 179

Query: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
           HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKD
Sbjct: 180 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 239

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287
           VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 299

Query: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347
           KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 300 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359

Query: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407
           HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 419

Query: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
           NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
           IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 480 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  943 bits (2437), Expect = 0.0
 Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118
           EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA   
Sbjct: 61  EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 120

Query: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167
                      S Q  +KN E T NGEEN AH++ NNH   ME+DG+VEIP +KA VLRG
Sbjct: 121 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 179

Query: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
           HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKD
Sbjct: 180 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 239

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287
           VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 299

Query: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347
           KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 300 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 359

Query: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407
           HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 419

Query: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
           NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
           IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 480 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 526


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  943 bits (2437), Expect = 0.0
 Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118
           EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA   
Sbjct: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171

Query: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167
                      S Q  +KN E T NGEEN AH++ NNH   ME+DG+VEIP +KA VLRG
Sbjct: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 230

Query: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
           HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKD
Sbjct: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 290

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287
           VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 350

Query: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347
           KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410

Query: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407
           HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470

Query: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
           NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
           IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 531 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  943 bits (2437), Expect = 0.0
 Identities = 455/527 (86%), Positives = 487/527 (92%), Gaps = 14/527 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPPAALISI+QKGLQYV
Sbjct: 52  MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYV 111

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAA-- 118
           EAE+SINEDGT+FDGRPIESLSLIDAVMPDVVQTRQQA+R+KLAQQQA+AAAAAAAA   
Sbjct: 112 EAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAA 171

Query: 119 -----------SQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRG 167
                      S Q  +KN E T NGEEN AH++ NNH   ME+DG+VEIP +KA VLRG
Sbjct: 172 ATAATTTSAGVSHQNPSKNREATVNGEENRAHSV-NNHAKPMEIDGEVEIPSSKATVLRG 230

Query: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
           HESEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKD
Sbjct: 231 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKD 290

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVD 287
           VTSLDWN+ GTLLATGSYDGFARIWT+DGNLASTLGQHKGPIFALKWN+KGN+ILSAGVD
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVD 350

Query: 288 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQG 347
           KTTIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG DRP+KTFQG
Sbjct: 351 KTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG 410

Query: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTN 407
           HTNEVNAIKWDP+G LLASCSDDMTLKIWSMKQ+ C+HDLQAHNKEIYTIKWSPTGP T+
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS 470

Query: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467
           NPN+N+MLASASFDSTVRLWD++RG+C HTLTKHQEPVYSVAFSPDG+YLASGSFDKCVH
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 468 IWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
           IWNTQ+G LVHSYRGTGGIFEVCWNA GDKVGASASDGSVCVLDLRK
Sbjct: 531 IWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK 577


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  916 bits (2368), Expect = 0.0
 Identities = 444/523 (84%), Positives = 478/523 (91%), Gaps = 12/523 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPP+ALISI+QKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAA----- 115
           EAE+SIN+DGT+FD RPIESLSLI AV+PDVVQ RQQA+ +KL QQQA+AAA  A     
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 116 ------AAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHE 169
                 AA SQQ   KN E T NGEENGAH I NNH+  ME+DGDVEIPPNKA VLRGHE
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKATVLRGHE 179

Query: 170 SEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVT 229
           SEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKDVT
Sbjct: 180 SEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVT 239

Query: 230 SLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289
           SLDWNS+GTLLA GSYDGFARIWT++GNLASTLGQHKGPIFALKWNKKGN++LSAGVDKT
Sbjct: 240 SLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299

Query: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHT 349
           TIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG D P+KTFQGHT
Sbjct: 300 TIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359

Query: 350 NEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNP 409
           NEVNAIKWDP+G LLASCSDDMTLKIWSMKQD CVHDLQAH+KEIYTIKWSPTGP T+NP
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 410 NANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
           N+++MLASASFDSTVRLWDV++G+C HTL KHQEPVYSVAFSPDG+YLASGSFDK VHIW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 470 NTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
           NTQ+G+LVHSY+GTGGIFEVCWNA GDKVGASASDGSVCVLDL
Sbjct: 480 NTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  916 bits (2368), Expect = 0.0
 Identities = 444/523 (84%), Positives = 478/523 (91%), Gaps = 12/523 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPP+ALISI+QKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAA----- 115
           EAE+SIN+DGT+FD RPIESLSLI AV+PDVVQ RQQA+ +KL QQQA+AAA  A     
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 116 ------AAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHE 169
                 AA SQQ   KN E T NGEENGAH I NNH+  ME+DGDVEIPPNKA VLRGHE
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKATVLRGHE 179

Query: 170 SEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVT 229
           SEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKDVT
Sbjct: 180 SEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVT 239

Query: 230 SLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289
           SLDWNS+GTLLA GSYDGFARIWT++GNLASTLGQHKGPIFALKWNKKGN++LSAGVDKT
Sbjct: 240 SLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299

Query: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHT 349
           TIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG D P+KTFQGHT
Sbjct: 300 TIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359

Query: 350 NEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNP 409
           NEVNAIKWDP+G LLASCSDDMTLKIWSMKQD CVHDLQAH+KEIYTIKWSPTGP T+NP
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 410 NANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
           N+++MLASASFDSTVRLWDV++G+C HTL KHQEPVYSVAFSPDG+YLASGSFDK VHIW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 470 NTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
           NTQ+G+LVHSY+GTGGIFEVCWNA GDKVGASASDGSVCVLDL
Sbjct: 480 NTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  916 bits (2368), Expect = 0.0
 Identities = 444/523 (84%), Positives = 478/523 (91%), Gaps = 12/523 (2%)

Query: 1   MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYV 60
           MSI+SDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNING LVPP+ALISI+QKGLQYV
Sbjct: 1   MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV 60

Query: 61  EAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAA----- 115
           EAE+SIN+DGT+FD RPIESLSLI AV+PDVVQ RQQA+ +KL QQQA+AAA  A     
Sbjct: 61  EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK 120

Query: 116 ------AAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHE 169
                 AA SQQ   KN E T NGEENGAH I NNH+  ME+DGDVEIPPNKA VLRGHE
Sbjct: 121 AATMTPAAISQQNPPKNREATVNGEENGAHEI-NNHSKPMEIDGDVEIPPNKATVLRGHE 179

Query: 170 SEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVT 229
           SEVFICAWNPVSDLLASGSGDSTARIWNL+ENS  GSTQLVLRHCIREGG DVPSNKDVT
Sbjct: 180 SEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVT 239

Query: 230 SLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289
           SLDWNS+GTLLA GSYDGFARIWT++GNLASTLGQHKGPIFALKWNKKGN++LSAGVDKT
Sbjct: 240 SLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299

Query: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHT 349
           TIIWDAHTGEAKQQFPFHSAPALDVDWQ+N TFASCSTDMCIHVC+LG D P+KTFQGHT
Sbjct: 300 TIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHT 359

Query: 350 NEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNP 409
           NEVNAIKWDP+G LLASCSDDMTLKIWSMKQD CVHDLQAH+KEIYTIKWSPTGP T+NP
Sbjct: 360 NEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNP 419

Query: 410 NANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIW 469
           N+++MLASASFDSTVRLWDV++G+C HTL KHQEPVYSVAFSPDG+YLASGSFDK VHIW
Sbjct: 420 NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479

Query: 470 NTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
           NTQ+G+LVHSY+GTGGIFEVCWNA GDKVGASASDGSVCVLDL
Sbjct: 480 NTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL 522


>gi|239748962 PREDICTED: hypothetical protein XP_002346868 [Homo
           sapiens]
          Length = 155

 Score =  226 bits (575), Expect = 5e-59
 Identities = 123/150 (82%), Positives = 127/150 (84%), Gaps = 15/150 (10%)

Query: 22  SHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESL 81
           SHSAFTFGIES ISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGT FDGRP+ SL
Sbjct: 9   SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67

Query: 82  SLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSA---------KNGENTAN 132
           SLIDA+MPDVVQTRQQAY DKL QQQ     AAAA A+QQGSA         KN ENTAN
Sbjct: 68  SLIDALMPDVVQTRQQAYSDKLKQQQ-----AAAATANQQGSAKKKKKKKKKKNAENTAN 122

Query: 133 GEENGAHTIANNHTDMMEVDGDVEIPPNKA 162
           GEENGAH IANNHTD MEVDGD+EIPPNKA
Sbjct: 123 GEENGAHIIANNHTDTMEVDGDIEIPPNKA 152


>gi|239742982 PREDICTED: hypothetical protein XP_002342710 [Homo
           sapiens]
          Length = 177

 Score =  226 bits (575), Expect = 5e-59
 Identities = 123/150 (82%), Positives = 127/150 (84%), Gaps = 15/150 (10%)

Query: 22  SHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESL 81
           SHSAFTFGIES ISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGT FDGRP+ SL
Sbjct: 31  SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 89

Query: 82  SLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSA---------KNGENTAN 132
           SLIDA+MPDVVQTRQQAY DKL QQQ     AAAA A+QQGSA         KN ENTAN
Sbjct: 90  SLIDALMPDVVQTRQQAYSDKLKQQQ-----AAAATANQQGSAKKKKKKKKKKNAENTAN 144

Query: 133 GEENGAHTIANNHTDMMEVDGDVEIPPNKA 162
           GEENGAH IANNHTD MEVDGD+EIPPNKA
Sbjct: 145 GEENGAHIIANNHTDTMEVDGDIEIPPNKA 174


>gi|239754401 PREDICTED: similar to transducin (beta)-like 1
           X-linked receptor 1 [Homo sapiens]
          Length = 132

 Score =  163 bits (413), Expect = 3e-40
 Identities = 90/104 (86%), Positives = 93/104 (89%), Gaps = 6/104 (5%)

Query: 22  SHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESL 81
           SHSAFTFGIES ISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGT FDGRP+ SL
Sbjct: 9   SHSAFTFGIESRISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTFFDGRPM-SL 67

Query: 82  SLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAK 125
           SLIDA+MPDVVQTRQQAY DKL QQQ     AAAA A+QQGSAK
Sbjct: 68  SLIDALMPDVVQTRQQAYSDKLKQQQ-----AAAATANQQGSAK 106


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  139 bits (350), Expect = 6e-33
 Identities = 91/309 (29%), Positives = 143/309 (46%), Gaps = 28/309 (9%)

Query: 165 LRGHESEVFICAWN-PVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           L GH + V+  A+N P  D +A+GS D T ++W++              H  R       
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCY--------HTFRG------ 175

Query: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFIL 282
              ++  L +N + TL+ATGS D  A++W  ++G    TL  H   I +L +N  G+ I+
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII 235

Query: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAP--ALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
           +   D T ++WDA TG        H A   +   +W  +      S D    +      +
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG-SMDKTCKLWDATNGK 294

Query: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
            + T  GH +E+    +D TG L+A+ S D T +I+S     C+  L+ H  EI  I ++
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354

Query: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
           P G        N +L  +S D T R+WD   G C+  L  H + ++S AF+  G  + +G
Sbjct: 355 PQG--------NHLLTGSS-DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405

Query: 461 SFDKCVHIW 469
           S D    IW
Sbjct: 406 SKDNTCRIW 414



 Score =  105 bits (261), Expect = 1e-22
 Identities = 64/252 (25%), Positives = 119/252 (47%), Gaps = 12/252 (4%)

Query: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
           L   L  H  P+  +  NK G+  ++   D+T  +WD  +GE       H      + + 
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 318 S--NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKI 375
           +   +  A+ S D    +  +   +   TF+GHT E+  + ++P   L+A+ S D T K+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 376 WSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICI 435
           W ++    V+ L+ H+ EI ++ ++ +G           + + SFD TV +WD D G  +
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGD---------RIITGSFDHTVVVWDADTGRKV 254

Query: 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAA 494
           + L  H   + S +F+ D   + +GS DK   +W+   G  V +  G    I + C++  
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT 314

Query: 495 GDKVGASASDGS 506
           G  +  +++DG+
Sbjct: 315 GKLIATASADGT 326



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 52/183 (28%), Positives = 89/183 (48%), Gaps = 14/183 (7%)

Query: 335 KLGQDRP-----IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQA 389
           KLGQ+        K  + H   +  +  + +G+   + S D T K+W       ++ L+ 
Sbjct: 73  KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG 132

Query: 390 HNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVA 449
           H   +Y I +       NNP  +  +A+ SFD T +LW V+ G C HT   H   +  ++
Sbjct: 133 HRNVVYAIAF-------NNPYGD-KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184

Query: 450 FSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVC 508
           F+P    +A+GS D    +W+ Q G  V++ RG +  I  + +N +GD++   + D +V 
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244

Query: 509 VLD 511
           V D
Sbjct: 245 VWD 247



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 56/217 (25%)

Query: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
           K  +L GH +E+   ++N    L+ +GS D T ++W    ++T+G     L       G 
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW----DATNGKCVATLT------GH 302

Query: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGN 279
           D     ++    ++  G L+AT S DG ARI++       + L  H+G I  + +N +GN
Sbjct: 303 D----DEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358

Query: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339
            +L+   DKT  IWDA TG+                              C+ V      
Sbjct: 359 HLLTGSSDKTARIWDAQTGQ------------------------------CLQV------ 382

Query: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
                 +GHT+E+ +  ++  GN++ + S D T +IW
Sbjct: 383 -----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  134 bits (336), Expect = 3e-31
 Identities = 84/283 (29%), Positives = 137/283 (48%), Gaps = 12/283 (4%)

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
           +TSLD +  G  LAT S+D F  +W  K    A     HK  + +++++  GN + SA  
Sbjct: 21  ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRPIKTF 345
           D+T  +W         +F  H+AP   VD+ ++  F A+ S D  I V  + + R + + 
Sbjct: 81  DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140

Query: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405
             HT+ V   K+ P G L+ SCS+D T+KIW      CV++          + ++P+G  
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGT- 199

Query: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
                    +ASA  D TV++WDV     +     H   V  ++F P G YL + S D  
Sbjct: 200 --------CIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251

Query: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSV 507
           + I +   G L+++ +G TG +F V ++  G+   +  +D  V
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294



 Score =  103 bits (258), Expect = 3e-22
 Identities = 64/262 (24%), Positives = 122/262 (46%), Gaps = 11/262 (4%)

Query: 253 TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPAL 312
           T+D  L      HK  I +L  +  G  + +A  D   ++W+        ++  H     
Sbjct: 5   TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64

Query: 313 DVDWQSN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDM 371
            V +  + N  AS S D  + +    +      F+ HT  V ++ +   G  LA+ S+D 
Sbjct: 65  SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124

Query: 372 TLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDR 431
           ++K+WSM +   ++ L  H   +   K+SP G          ++ S S D T+++WD   
Sbjct: 125 SIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR---------LIVSCSEDKTIKIWDTTN 175

Query: 432 GICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVC 490
             C++  +        V F+P G  +AS   D+ V +W+ +   L+  Y+  +GG+  + 
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235

Query: 491 WNAAGDKVGASASDGSVCVLDL 512
           ++ +G+ +  ++SDG++ +LDL
Sbjct: 236 FHPSGNYLITASSDGTLKILDL 257



 Score =  100 bits (248), Expect = 4e-21
 Identities = 73/272 (26%), Positives = 120/272 (44%), Gaps = 25/272 (9%)

Query: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
           P  +A    GH+  V    ++P  +LLAS S D T R+W   +       +         
Sbjct: 49  PHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-------- 100

Query: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNK 276
                     V S+D++++G  LAT S D   ++W+        +L +H   +   K++ 
Sbjct: 101 ------HTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP 154

Query: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335
            G  I+S   DKT  IWD    +    F      A  VD+  + T  AS  +D  + V  
Sbjct: 155 DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD 214

Query: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
           +  ++ ++ +Q H+  VN I + P+GN L + S D TLKI  + +   ++ LQ H   ++
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVF 274

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427
           T+ +S  G          + AS   D+ V LW
Sbjct: 275 TVSFSKGGE---------LFASGGADTQVLLW 297



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 60/215 (27%), Positives = 106/215 (49%), Gaps = 11/215 (5%)

Query: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359
           ++ F  H A    +D   N    A+ S D  + +           + GH + V ++++ P
Sbjct: 11  ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70

Query: 360 TGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASAS 419
            GNLLAS S D T+++W   +     + +AH   + ++ +S  G           LA+AS
Sbjct: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ---------FLATAS 121

Query: 420 FDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHS 479
            D ++++W + R   +++L +H   V    FSPDGR + S S DK + IW+T     V++
Sbjct: 122 EDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181

Query: 480 YRGTGGIFE-VCWNAAGDKVGASASDGSVCVLDLR 513
           +  + G    V +N +G  + ++ SD +V V D+R
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 15/124 (12%)

Query: 177 WNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSE 236
           +NP    +AS   D T ++W++  N      +L+  + +  GG        V  + ++  
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVN------KLLQHYQVHSGG--------VNCISFHPS 239

Query: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
           G  L T S DG  +I    +G L  TL  H GP+F + ++K G    S G D   ++W  
Sbjct: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299

Query: 296 HTGE 299
           +  E
Sbjct: 300 NFDE 303


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  127 bits (318), Expect = 3e-29
 Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 15/263 (5%)

Query: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
           K V+S+ ++  G  LA+ S D   +IW   DG    T+  HK  I  + W+   N ++SA
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
             DKT  IWD  +G+  +    HS      ++   +N   S S D  + +  +   + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPT 402
           T   H++ V+A+ ++  G+L+ S S D   +IW      C+  L    N  +  +K+SP 
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLAS 459
           G           + +A+ D+T++LWD  +G C+ T T H+   Y +  +     G+++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 460 GSFDKCVHIWNTQTGALVHSYRG 482
           GS D  V+IWN QT  +V   +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299



 Score =  123 bits (309), Expect = 3e-28
 Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 11/227 (4%)

Query: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
           L  TL  H   + ++K++  G ++ S+  DK   IW A+ G+ ++    H     DV W 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 318 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
           S+ N   S S D  + +  +   + +KT +GH+N V    ++P  NL+ S S D +++IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
            +K   C+  L AH+  +  + ++  G          ++ S+S+D   R+WD   G C+ 
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207

Query: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
           TL     P  S V FSP+G+Y+ + + D  + +W+   G  + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254



 Score =  112 bits (280), Expect = 8e-25
 Identities = 83/325 (25%), Positives = 136/325 (41%), Gaps = 33/325 (10%)

Query: 157 IPPNKAV--VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHC 214
           + PN A+   L GH   V    ++P  + LAS S D   +IW   +              
Sbjct: 31  VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE---------- 80

Query: 215 IREGGQDVPSNK-DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFAL 272
                + +  +K  ++ + W+S+  LL + S D   +IW    G    TL  H   +F  
Sbjct: 81  -----KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 273 KWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QSNNTFASCSTDMCI 331
            +N + N I+S   D++  IWD  TG+  +  P HS P   V + +  +   S S D   
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195

Query: 332 HVCKLGQDRPIKTFQGHTN-EVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 390
            +      + +KT     N  V+ +K+ P G  + + + D TLK+W   +  C+     H
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255

Query: 391 NKEIYTI--KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSV 448
             E Y I   +S TG           + S S D+ V +W++     +  L  H + V S 
Sbjct: 256 KNEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307

Query: 449 AFSPDGRYLASGSF--DKCVHIWNT 471
           A  P    +AS +   DK + +W +
Sbjct: 308 ACHPTENIIASAALENDKTIKLWKS 332



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/128 (27%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
           L  H K + ++K+SP G           LAS+S D  +++W    G    T++ H+  + 
Sbjct: 41  LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91

Query: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDG 505
            VA+S D   L S S DK + IW+  +G  + + +G       C +N   + + + + D 
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 506 SVCVLDLR 513
           SV + D++
Sbjct: 152 SVRIWDVK 159



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 26/77 (33%), Positives = 43/77 (55%), Gaps = 1/77 (1%)

Query: 437 TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG-GIFEVCWNAAG 495
           TL  H + V SV FSP+G +LAS S DK + IW    G    +  G   GI +V W++  
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 496 DKVGASASDGSVCVLDL 512
           + + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  127 bits (318), Expect = 3e-29
 Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 15/263 (5%)

Query: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
           K V+S+ ++  G  LA+ S D   +IW   DG    T+  HK  I  + W+   N ++SA
Sbjct: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
             DKT  IWD  +G+  +    HS      ++   +N   S S D  + +  +   + +K
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPT 402
           T   H++ V+A+ ++  G+L+ S S D   +IW      C+  L    N  +  +K+SP 
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLAS 459
           G           + +A+ D+T++LWD  +G C+ T T H+   Y +  +     G+++ S
Sbjct: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276

Query: 460 GSFDKCVHIWNTQTGALVHSYRG 482
           GS D  V+IWN QT  +V   +G
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQG 299



 Score =  123 bits (309), Expect = 3e-28
 Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 11/227 (4%)

Query: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
           L  TL  H   + ++K++  G ++ S+  DK   IW A+ G+ ++    H     DV W 
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96

Query: 318 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
           S+ N   S S D  + +  +   + +KT +GH+N V    ++P  NL+ S S D +++IW
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
            +K   C+  L AH+  +  + ++  G          ++ S+S+D   R+WD   G C+ 
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207

Query: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
           TL     P  S V FSP+G+Y+ + + D  + +W+   G  + +Y G
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254



 Score =  112 bits (280), Expect = 8e-25
 Identities = 83/325 (25%), Positives = 136/325 (41%), Gaps = 33/325 (10%)

Query: 157 IPPNKAV--VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHC 214
           + PN A+   L GH   V    ++P  + LAS S D   +IW   +              
Sbjct: 31  VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE---------- 80

Query: 215 IREGGQDVPSNK-DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFAL 272
                + +  +K  ++ + W+S+  LL + S D   +IW    G    TL  H   +F  
Sbjct: 81  -----KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135

Query: 273 KWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW-QSNNTFASCSTDMCI 331
            +N + N I+S   D++  IWD  TG+  +  P HS P   V + +  +   S S D   
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195

Query: 332 HVCKLGQDRPIKTFQGHTN-EVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAH 390
            +      + +KT     N  V+ +K+ P G  + + + D TLK+W   +  C+     H
Sbjct: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255

Query: 391 NKEIYTI--KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSV 448
             E Y I   +S TG           + S S D+ V +W++     +  L  H + V S 
Sbjct: 256 KNEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307

Query: 449 AFSPDGRYLASGSF--DKCVHIWNT 471
           A  P    +AS +   DK + +W +
Sbjct: 308 ACHPTENIIASAALENDKTIKLWKS 332



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/128 (27%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
           L  H K + ++K+SP G           LAS+S D  +++W    G    T++ H+  + 
Sbjct: 41  LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91

Query: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDG 505
            VA+S D   L S S DK + IW+  +G  + + +G       C +N   + + + + D 
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151

Query: 506 SVCVLDLR 513
           SV + D++
Sbjct: 152 SVRIWDVK 159



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 26/77 (33%), Positives = 43/77 (55%), Gaps = 1/77 (1%)

Query: 437 TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG-GIFEVCWNAAG 495
           TL  H + V SV FSP+G +LAS S DK + IW    G    +  G   GI +V W++  
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 496 DKVGASASDGSVCVLDL 512
           + + +++ D ++ + D+
Sbjct: 100 NLLVSASDDKTLKIWDV 116


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  125 bits (315), Expect = 7e-29
 Identities = 103/384 (26%), Positives = 150/384 (39%), Gaps = 89/384 (23%)

Query: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSEN----STSGSTQLVLRHCIREGGQ 220
           L GH   V   A++P    LASGSGD+T R W+LS      +  G    VL       G+
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169

Query: 221 DVPS-------------------------NKDVTSLDW-----NSEGTLLATGSYDGFAR 250
            + S                         +K +T L W     N E   +A+ S DG  R
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 251 IW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH-- 307
           IW T  G     L  H   +  L+W   G  + SA  D+T  +W AH G   +    H  
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288

Query: 308 --SAPALDVDW---------------------------------------QSNNTFASCS 326
             +  AL  D+                                       Q      S S
Sbjct: 289 WVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGS 348

Query: 327 TDMCIHVCKLGQD-RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVH 385
            D  + +    +D +P+    GH   +N + + P   ++AS S D ++K+W  +    + 
Sbjct: 349 DDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLA 408

Query: 386 DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPV 445
            L+ H   +Y I WS           + +L S S DST+++WDV        L  H + V
Sbjct: 409 SLRGHVAAVYQIAWSAD---------SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459

Query: 446 YSVAFSPDGRYLASGSFDKCVHIW 469
           Y+V +SPDG+ +ASG  DKC+ IW
Sbjct: 460 YAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 57/226 (25%), Positives = 86/226 (38%), Gaps = 47/226 (20%)

Query: 260 STLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN 319
           S+L  H   + ++ ++  G ++ S   D T   WD                         
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142

Query: 320 NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMK 379
                           L  + P  T +GH + V +I W P G  LAS   +  + +W   
Sbjct: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186

Query: 380 QDNCV-HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTL 438
               V   L  H+K I  + W P      NP     +AS+S D +VR+WD   G C   L
Sbjct: 187 TGKQVGRTLAGHSKWITGLSWEPLHA---NPECR-YVASSSKDGSVRIWDTTAGRCERIL 242

Query: 439 TKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG 484
           T H + V  + +  DG  L S S D+ + +W    G L  + +G G
Sbjct: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 47/136 (34%), Positives = 69/136 (50%), Gaps = 16/136 (11%)

Query: 383 CVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQ 442
           C   L+ H++ + ++ +SPTG           LAS S D+TVR WD+       T   H+
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156

Query: 443 EPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV------HSYRGTGGIFE-VCWNAAG 495
             V S+++SPDGR LASG  +  + +W+  TG  V      HS   TG  +E +  N   
Sbjct: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216

Query: 496 DKVGASASDGSVCVLD 511
             V +S+ DGSV + D
Sbjct: 217 RYVASSSKDGSVRIWD 232



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 16/91 (17%)

Query: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
           LRGH + V+  AW+  S LL SGS DST ++W++     +                D+P 
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLA---------------MDLPG 454

Query: 225 NKD-VTSLDWNSEGTLLATGSYDGFARIWTK 254
           + D V ++DW+ +G  +A+G  D   RIW +
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 15/35 (42%), Positives = 19/35 (54%)

Query: 162 AVVLRGHESEVFICAWNPVSDLLASGSGDSTARIW 196
           A+ L GH  EV+   W+P    +ASG  D   RIW
Sbjct: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  124 bits (312), Expect = 2e-28
 Identities = 66/227 (29%), Positives = 117/227 (51%), Gaps = 11/227 (4%)

Query: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
           L  TL  H   + ++K++  G ++ S+  D+  IIW A+ G+ ++    H+    DV W 
Sbjct: 33  LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92

Query: 318 SNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
           S+++   S S D  + +  +   + +KT +GH+N V    ++P  NL+ S S D T+KIW
Sbjct: 93  SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152

Query: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
            +K   C+  L AH+  +  + ++ +G          ++ S S+D   R+WD   G C+ 
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGS---------LIVSGSYDGLCRIWDAASGQCLK 203

Query: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
           TL     P  S V FSP+G+Y+ + + D  + +W+   G  + +Y G
Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250



 Score =  119 bits (297), Expect = 9e-27
 Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 15/261 (5%)

Query: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
           V+S+ ++  G  LA+ S D    IW   DG    TL  H   I  + W+   + ++SA  
Sbjct: 44  VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIKTF 345
           DKT  +WD  +G+  +    HS      ++   +N   S S D  + + ++   + +KT 
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163

Query: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPTGP 404
             H++ V+A+ ++ +G+L+ S S D   +IW      C+  L    N  +  +K+SP G 
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223

Query: 405 GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLASGS 461
                     + +A+ D+T++LWD  RG C+ T T H+   Y +  +     G+++ SGS
Sbjct: 224 ---------YILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 274

Query: 462 FDKCVHIWNTQTGALVHSYRG 482
            D  V+IWN QT  +V   +G
Sbjct: 275 EDNLVYIWNLQTKEIVQKLQG 295



 Score =  107 bits (267), Expect = 3e-23
 Identities = 82/325 (25%), Positives = 134/325 (41%), Gaps = 33/325 (10%)

Query: 156 EIPPNKAVVLR----GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVL 211
           E+P N    L+    GH   V    ++P  + LAS S D    IW   +       + + 
Sbjct: 24  EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE---KTLY 80

Query: 212 RHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIF 270
            H           N +++ + W+S+ + L + S D   ++W  + G    TL  H   +F
Sbjct: 81  GH-----------NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVF 129

Query: 271 ALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDM 329
              +N   N I+S   D+T  IW+  TG+  +    HS P   V +  S +   S S D 
Sbjct: 130 CCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDG 189

Query: 330 CIHVCKLGQDRPIKTFQGHTN-EVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQ 388
              +      + +KT     N  V+ +K+ P G  + + + D TLK+W   +  C+    
Sbjct: 190 LCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249

Query: 389 AHNKEIYTI--KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
            H  E Y I   +S TG           + S S D+ V +W++     +  L  H + V 
Sbjct: 250 GHKNEKYCIFANFSVTG--------GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301

Query: 447 SVAFSPDGRYLASGSF--DKCVHIW 469
           S A  P    +AS +   DK + +W
Sbjct: 302 SAACHPTENLIASAALENDKTIKLW 326



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 56/169 (33%), Positives = 82/169 (48%), Gaps = 10/169 (5%)

Query: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTG 403
           T  GHT  V+++K+ P G  LAS S D  + IW          L  HN EI  + WS   
Sbjct: 36  TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS--- 92

Query: 404 PGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFD 463
                 + +  L SAS D T++LWDV  G C+ TL  H   V+   F+P    + SGSFD
Sbjct: 93  ------SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146

Query: 464 KCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLD 511
           + V IW  +TG  + +    +  +  V +N +G  + + + DG   + D
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score =  124 bits (311), Expect = 2e-28
 Identities = 83/259 (32%), Positives = 125/259 (48%), Gaps = 59/259 (22%)

Query: 222 VPSNKDVTS--LDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQ-HKGPIFALKWN 275
           VP++ D     L WN  GTLLA+   D   RIW  +G+     S L + H+  +  + W+
Sbjct: 11  VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70

Query: 276 KKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCK 335
             GN++ SA  D TT I                       W+ N     C T        
Sbjct: 71  PCGNYLASASFDATTCI-----------------------WKKNQDDFECVT-------- 99

Query: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN---CVHDLQAHNK 392
                   T +GH NEV ++ W P+GNLLA+CS D ++ +W + +++   CV  L +H +
Sbjct: 100 --------TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151

Query: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLW--DVDRGICIHTLTKHQEPVYSVAF 450
           ++  + W P         +  +LASAS+D TV+L+  + D  +C  TL  H+  V+S+AF
Sbjct: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202

Query: 451 SPDGRYLASGSFDKCVHIW 469
            P G+ LAS S D+ V IW
Sbjct: 203 DPSGQRLASCSDDRTVRIW 221



 Score =  108 bits (269), Expect = 2e-23
 Identities = 95/340 (27%), Positives = 142/340 (41%), Gaps = 57/340 (16%)

Query: 169 ESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDV 228
           +S  +  AWNP   LLAS  GD   RIW    +S       + +  + EG Q     + V
Sbjct: 16  DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEGHQ-----RTV 64

Query: 229 TSLDWNSEGTLLATGSYDGFARIWTK---DGNLASTLGQHKGPIFALKWNKKGNFILSAG 285
             + W+  G  LA+ S+D    IW K   D    +TL  H+  + ++ W   GN + +  
Sbjct: 65  RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124

Query: 286 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRP 341
            DK+  +W+       E       H+     V W  S    AS S D  + + +  +D  
Sbjct: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184

Query: 342 I--KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW---------------SMKQDNCV 384
           +   T +GH + V ++ +DP+G  LASCSDD T++IW               S     C+
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244

Query: 385 HDLQA-HNKEIYTIKWSP-TGPGTNNPNANLMLASASFDSTVRLWDVDR---------GI 433
             L   H++ IY I W   TG           LA+A  D  +R++  D           +
Sbjct: 245 CTLSGFHSRTIYDIAWCQLTG----------ALATACGDDAIRVFQEDPNSDPQQPTFSL 294

Query: 434 CIHTLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQ 472
             H    H + V  VA++P +   LAS S D  V  W  Q
Sbjct: 295 TAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)

Query: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG----IFEVCWNAAGDKVGASAS 503
           +A++P G  LAS   D+ + IW T+  + +     + G    + +V W+  G+ + +++ 
Sbjct: 22  LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81

Query: 504 DGSVCV 509
           D + C+
Sbjct: 82  DATTCI 87


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  123 bits (309), Expect = 3e-28
 Identities = 80/292 (27%), Positives = 128/292 (43%), Gaps = 36/292 (12%)

Query: 181 SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLL 240
           S L+A G  DST R+W+++                          K + S+   S+ +L+
Sbjct: 482 SSLIAGGFADSTVRVWSVTP-------------------------KKLRSVKQASDLSLI 516

Query: 241 ATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGE 299
              S D   RI   K  +    L  H GP++   ++   N++LS+  D T  +W   T  
Sbjct: 517 DKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576

Query: 300 AKQQFPFHSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWD 358
               +  H+ P  D  +      F S   D    +      +P++ F GH  +VN  ++ 
Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636

Query: 359 PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASA 418
           P  N +A+ S D T+++W +   NCV     H   I+++ +SP G           LA+ 
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG---------RFLATG 687

Query: 419 SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
           + D  V LWD+  G+ +  L  H + V S+ FS DG  LASGS D  V +W+
Sbjct: 688 ATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 59/208 (28%), Positives = 101/208 (48%), Gaps = 36/208 (17%)

Query: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
           +K   GH+  V    + P  N L S S+D T+++WS++   C+   + HN  ++  ++SP
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595

Query: 402 TG------------------------------PGTN----NPNANLMLASASFDSTVRLW 427
            G                                 N    +PN+N + A+ S D TVRLW
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV-ATGSADRTVRLW 654

Query: 428 DVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGI 486
           DV  G C+   T H+ P++S+ FSP+GR+LA+G+ D  V +W+   G +V   +G T  +
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714

Query: 487 FEVCWNAAGDKVGASASDGSVCVLDLRK 514
             + ++  G+ + + + D +V + D  K
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWDAIK 742



 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 16/215 (7%)

Query: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           +L GH   V+  +++P  + L S S D T R+W+L                +   G + P
Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ----------TFTCLVGYKGHNYP 587

Query: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282
               V    ++  G    +G +D  AR+W  D          H   +   +++   N++ 
Sbjct: 588 ----VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKLGQDRP 341
           +   D+T  +WD   G   + F  H  P   + +  N  F A+ +TD  + +  +G    
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703

Query: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
           +   +GHT+ V ++++   G +LAS S D T+++W
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 10/91 (10%)

Query: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNL--------SENSTSGSTQLVLRHCIR 216
           L+GH   V    ++   ++LASGS D+T R+W+         +++ T+ +  + L    +
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQ 766

Query: 217 E--GGQDVPSNKDVTSLDWNSEGTLLATGSY 245
           E   G  +  +  V  L +     +LA G+Y
Sbjct: 767 ELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score =  120 bits (302), Expect = 2e-27
 Identities = 100/376 (26%), Positives = 162/376 (43%), Gaps = 48/376 (12%)

Query: 119 SQQGSAKNGENTANGE--------ENGAHTIANNHTDMMEVDGDV---EIPPNKAVVLR- 166
           S Q   KN   ++  E        +N A ++   H     +DG V   ++   K   LR 
Sbjct: 306 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 365

Query: 167 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
            GH   +F C + P   +LLA+ S D T ++W+++  +   ++               P 
Sbjct: 366 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTS---------------PG 410

Query: 225 NKDVT-SLDWNSEG-TLLATGSYDGFARIWT-KDGNLASTLGQH-KGPIFALKWNKKGNF 280
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 411 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 470

Query: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT---FASCS-TDMCIHVCKL 336
            ++        I     G+   ++  H A     DW  NN       C  T++ ++    
Sbjct: 471 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 529

Query: 337 GQDRPIKTFQGHTNEVNAIKWDPTGN-LLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   QD C++ L  H   + 
Sbjct: 530 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 589

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGR 455
            + W+   P         +L S S+D T+++WD   G C+ T+  H   VY +   P   
Sbjct: 590 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 641

Query: 456 Y-LASGSFDKCVHIWN 470
           + +AS S D  V +W+
Sbjct: 642 FTMASCSRDSTVRLWS 657



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 69/256 (26%), Positives = 118/256 (46%), Gaps = 35/256 (13%)

Query: 239 LLATGSYDGFARIWTKDGNLAS-TLGQHKGPIFALKWNKKGNFILSAGVDKT-TIIWDAH 296
           LLAT S+DG  ++W  +   A  T   ++G I++L W   G   ++ G  +    IW+  
Sbjct: 384 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 443

Query: 297 TGEAKQQFPFHSAPALD-VDWQSNNT--FASCSTD-MCIHVCKLGQDRPIKTFQG----- 347
            G+  Q+F  H    +  + W   ++   A+CS+D  CI          I+T  G     
Sbjct: 444 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 493

Query: 348 --HTNEVNAIKWDPTG-NLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPT 402
             H   V    W     +++A+  +D  ++++  +   D  +     H  +++ +KWSP 
Sbjct: 494 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 553

Query: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRY-LASGS 461
             G        +L S S D TVR+WD  +  CI+ L  H  PV  + ++ +  Y L SGS
Sbjct: 554 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 605

Query: 462 FDKCVHIWNTQTGALV 477
           +D  + +W+T+ G  V
Sbjct: 606 WDYTIKVWDTREGTCV 621



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 370 DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV 429
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 354 DMGAKKWDFLRD------LGHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 399

Query: 430 DRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSFDKCVHIWNTQTGALVHSY--RGTGGI 486
           +    ++T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 400 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 459

Query: 487 FEVCWNAAGDKVGASASDGSVCVL 510
           F + W+    K  A+ S    C++
Sbjct: 460 FCIAWSHKDSKRIATCSSDGFCII 483



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 73/283 (25%), Positives = 116/283 (40%), Gaps = 27/283 (9%)

Query: 243 GSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAK 301
           G YD  A+ W    +    LG H   IF  K+     N + +A  D T  +WD +T  A 
Sbjct: 351 GLYDMGAKKW----DFLRDLG-HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAV 405

Query: 302 QQFPFHSAPALDVDWQSN--NTFASCSTDMCIHVCKLGQDRPIKTFQGH-TNEVNAIKWD 358
              P +      + W     N  A  ++     +  + + + I+ F  H TN +  I W 
Sbjct: 406 YTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWS 465

Query: 359 -PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
                 +A+CS D    I ++  D  V     H   ++   WS      NN +   M+A+
Sbjct: 466 HKDSKRIATCSSDGFCIIRTI--DGKVLHKYKHPAAVFGCDWSQ-----NNKD---MIAT 515

Query: 418 ASFDSTVRLWDVDRGIC--IHTLTKHQEPVYSVAFSP--DGRYLASGSFDKCVHIWNTQT 473
              D+ VR++ V       +   + H   V+ V +SP  +G  L SGS D  V IW+   
Sbjct: 516 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQ 574

Query: 474 GALVHSYRG-TGGIFEVCWNAAGDKVGASAS-DGSVCVLDLRK 514
            A ++   G T  +  + WN     +  S S D ++ V D R+
Sbjct: 575 DACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 617



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 89/394 (22%), Positives = 146/394 (37%), Gaps = 85/394 (21%)

Query: 164 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222
           ++  H+  +   +W P + DL ASGS D+   IWN++E                +  + +
Sbjct: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL---------DSTKGI 104

Query: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHK------GPIFALKW-- 274
           P++    S  WN+E  ++A  S+ G   IWT  G  +  +  HK        I   +W  
Sbjct: 105 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 159

Query: 275 NKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH-----------SAPALDVDWQSNNTFA 323
           ++KG  ++   +D +  I+  H G   Q+                  AL+ D  S +   
Sbjct: 160 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 216

Query: 324 SCSTDMCIHVCKLGQDRPIKTFQ--GHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSMK 379
             +    I +        I TF        V  + W P+  G  +   S    L+IW++ 
Sbjct: 217 VVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVS 276

Query: 380 Q----DN---------CVH----------DLQAHNKEIYTIKWSPTGPG---TNNPNANL 413
           +    DN         C+H           +Q+  K  YT   S   P    T N   +L
Sbjct: 277 RTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSL 336

Query: 414 MLASA----------SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSF 462
               A           +D   + WD  R +       H E ++   F PD    LA+ SF
Sbjct: 337 PPGHAVCCFLDGGVGLYDMGAKKWDFLRDL------GHVETIFDCKFKPDDPNLLATASF 390

Query: 463 DKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAG 495
           D  + +W+  T   V++  G  G I+ + W   G
Sbjct: 391 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 424


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score =  120 bits (302), Expect = 2e-27
 Identities = 100/376 (26%), Positives = 162/376 (43%), Gaps = 48/376 (12%)

Query: 119 SQQGSAKNGENTANGE--------ENGAHTIANNHTDMMEVDGDV---EIPPNKAVVLR- 166
           S Q   KN   ++  E        +N A ++   H     +DG V   ++   K   LR 
Sbjct: 330 SVQSPTKNHYTSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRD 389

Query: 167 -GHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
            GH   +F C + P   +LLA+ S D T ++W+++  +   ++               P 
Sbjct: 390 LGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTS---------------PG 434

Query: 225 NKDVT-SLDWNSEG-TLLATGSYDGFARIWT-KDGNLASTLGQH-KGPIFALKWNKKGNF 280
           N+ V  SL W   G   +A G+    A IW  + G +     +H    IF + W+ K + 
Sbjct: 435 NEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSK 494

Query: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT---FASCS-TDMCIHVCKL 336
            ++        I     G+   ++  H A     DW  NN       C  T++ ++    
Sbjct: 495 RIATCSSDGFCIIRTIDGKVLHKYK-HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVAT 553

Query: 337 GQDRPIKTFQGHTNEVNAIKWDPTGN-LLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
             D+P+K F GHT +V  +KW P    +L S SDD T++IW   QD C++ L  H   + 
Sbjct: 554 SSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVR 613

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGR 455
            + W+   P         +L S S+D T+++WD   G C+ T+  H   VY +   P   
Sbjct: 614 GLMWNTEIP--------YLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRP 665

Query: 456 Y-LASGSFDKCVHIWN 470
           + +AS S D  V +W+
Sbjct: 666 FTMASCSRDSTVRLWS 681



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 69/256 (26%), Positives = 118/256 (46%), Gaps = 35/256 (13%)

Query: 239 LLATGSYDGFARIWTKDGNLAS-TLGQHKGPIFALKWNKKGNFILSAGVDKT-TIIWDAH 296
           LLAT S+DG  ++W  +   A  T   ++G I++L W   G   ++ G  +    IW+  
Sbjct: 408 LLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 467

Query: 297 TGEAKQQFPFHSAPALD-VDWQSNNT--FASCSTD-MCIHVCKLGQDRPIKTFQG----- 347
            G+  Q+F  H    +  + W   ++   A+CS+D  CI          I+T  G     
Sbjct: 468 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCI----------IRTIDGKVLHK 517

Query: 348 --HTNEVNAIKWDPTG-NLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPT 402
             H   V    W     +++A+  +D  ++++  +   D  +     H  +++ +KWSP 
Sbjct: 518 YKHPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPL 577

Query: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRY-LASGS 461
             G        +L S S D TVR+WD  +  CI+ L  H  PV  + ++ +  Y L SGS
Sbjct: 578 REG--------ILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGS 629

Query: 462 FDKCVHIWNTQTGALV 477
           +D  + +W+T+ G  V
Sbjct: 630 WDYTIKVWDTREGTCV 645



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 17/144 (11%)

Query: 370 DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV 429
           DM  K W   +D        H + I+  K+ P  P         +LA+ASFD T+++WD+
Sbjct: 378 DMGAKKWDFLRD------LGHVETIFDCKFKPDDPN--------LLATASFDGTIKVWDI 423

Query: 430 DRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSFDKCVHIWNTQTGALVHSY--RGTGGI 486
           +    ++T   ++  +YS++++P G   +A G+      IWN Q G ++  +   GT GI
Sbjct: 424 NTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGI 483

Query: 487 FEVCWNAAGDKVGASASDGSVCVL 510
           F + W+    K  A+ S    C++
Sbjct: 484 FCIAWSHKDSKRIATCSSDGFCII 507



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 73/283 (25%), Positives = 116/283 (40%), Gaps = 27/283 (9%)

Query: 243 GSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKG-NFILSAGVDKTTIIWDAHTGEAK 301
           G YD  A+ W    +    LG H   IF  K+     N + +A  D T  +WD +T  A 
Sbjct: 375 GLYDMGAKKW----DFLRDLG-HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAV 429

Query: 302 QQFPFHSAPALDVDWQSN--NTFASCSTDMCIHVCKLGQDRPIKTFQGH-TNEVNAIKWD 358
              P +      + W     N  A  ++     +  + + + I+ F  H TN +  I W 
Sbjct: 430 YTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWS 489

Query: 359 -PTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
                 +A+CS D    I ++  D  V     H   ++   WS      NN +   M+A+
Sbjct: 490 HKDSKRIATCSSDGFCIIRTI--DGKVLHKYKHPAAVFGCDWSQ-----NNKD---MIAT 539

Query: 418 ASFDSTVRLWDVDRGIC--IHTLTKHQEPVYSVAFSP--DGRYLASGSFDKCVHIWNTQT 473
              D+ VR++ V       +   + H   V+ V +SP  +G  L SGS D  V IW+   
Sbjct: 540 GCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREG-ILCSGSDDGTVRIWDYTQ 598

Query: 474 GALVHSYRG-TGGIFEVCWNAAGDKVGASAS-DGSVCVLDLRK 514
            A ++   G T  +  + WN     +  S S D ++ V D R+
Sbjct: 599 DACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE 641



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 89/394 (22%), Positives = 146/394 (37%), Gaps = 85/394 (21%)

Query: 164 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222
           ++  H+  +   +W P + DL ASGS D+   IWN++E                +  + +
Sbjct: 78  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKL---------DSTKGI 128

Query: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHK------GPIFALKW-- 274
           P++    S  WN+E  ++A  S+ G   IWT  G  +  +  HK        I   +W  
Sbjct: 129 PAS---LSWCWNAE-DVVAFVSHRGPLFIWTISGPDSGVI-VHKDAHSFLSDICMFRWHT 183

Query: 275 NKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH-----------SAPALDVDWQSNNTFA 323
           ++KG  ++   +D +  I+  H G   Q+                  AL+ D  S +   
Sbjct: 184 HQKGK-VVFGHIDGSLSIF--HPGNKNQKHVLRPESLEGTDEEDPVTALEWDPLSTDYLL 240

Query: 324 SCSTDMCIHVCKLGQDRPIKTFQ--GHTNEVNAIKWDPT--GNLLASCSDDMTLKIWSMK 379
             +    I +        I TF        V  + W P+  G  +   S    L+IW++ 
Sbjct: 241 VVNLHYGIRLVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGDSQVGVLRIWNVS 300

Query: 380 Q----DN---------CVH----------DLQAHNKEIYTIKWSPTGPG---TNNPNANL 413
           +    DN         C+H           +Q+  K  YT   S   P    T N   +L
Sbjct: 301 RTTPIDNLKLKKTGFHCLHVLNSPPRKKFSVQSPTKNHYTSSTSEAVPPPTLTQNQAFSL 360

Query: 414 MLASA----------SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDG-RYLASGSF 462
               A           +D   + WD  R +       H E ++   F PD    LA+ SF
Sbjct: 361 PPGHAVCCFLDGGVGLYDMGAKKWDFLRDL------GHVETIFDCKFKPDDPNLLATASF 414

Query: 463 DKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAG 495
           D  + +W+  T   V++  G  G I+ + W   G
Sbjct: 415 DGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGG 448


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  117 bits (292), Expect = 3e-26
 Identities = 77/285 (27%), Positives = 126/285 (44%), Gaps = 12/285 (4%)

Query: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
           VT +D++     LA+GS D    +W  K  + A     HK  +  + ++  G+ + S   
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIKTF 345
           DKT  IW  +       F  H+A    V + S+  +F + S D  + V    + + + + 
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405
             H N V   K+ P G L+ S SDD T+K+W      CVH    H   +  + + P+G  
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT- 200

Query: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
                    +A+A  D+TV++WDV     +     H   V  ++F P G YL + S D  
Sbjct: 201 --------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252

Query: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCV 509
           + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297



 Score =  104 bits (259), Expect = 2e-22
 Identities = 82/297 (27%), Positives = 127/297 (42%), Gaps = 26/297 (8%)

Query: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
           P ++A    GH+  V    ++P   LLASGS D T RIW     +  G + +   H    
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGESTVFRAH---- 102

Query: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNK 276
                     V S+ + S+G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 103 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
           +   R ++ +Q H+  VN + + P+GN L + S D TLKI  + +   ++ L  H     
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFS 451
           T+ +S TG            AS   D  V +W  +  I  H  +TK   P  ++A S
Sbjct: 276 TVAFSRTGE---------YFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASS 323



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 15/217 (6%)

Query: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359
           ++ F  H      VD+  N    AS S D C+ V  +        F GH + V  + + P
Sbjct: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 360 TGNLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
           +G+LLAS S D T++IW  ++K ++ V   +AH   + ++ +   G             +
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120

Query: 418 ASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV 477
           AS D TV++W   R   + +L++H   V    FSPDGR + S S DK V +W+  +   V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 478 HSYRGTGG-IFEVCWNAAGDKVGASASDGSVCVLDLR 513
           HSY   GG +  V ++ +G  + A+  D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 61/261 (23%), Positives = 116/261 (44%), Gaps = 11/261 (4%)

Query: 254 KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313
           +D +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 314 VDWQ-SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372
           V++  S +  AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 373 LKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG 432
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177

Query: 433 ICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVCW 491
            C+H+  +H   V  V F P G  +A+   D  V +W+ +T  L+  Y+  +  +  + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237

Query: 492 NAAGDKVGASASDGSVCVLDL 512
           + +G+ +  ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  117 bits (292), Expect = 3e-26
 Identities = 77/285 (27%), Positives = 126/285 (44%), Gaps = 12/285 (4%)

Query: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
           VT +D++     LA+GS D    +W  K  + A     HK  +  + ++  G+ + S   
Sbjct: 22  VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIKTF 345
           DKT  IW  +       F  H+A    V + S+  +F + S D  + V    + + + + 
Sbjct: 82  DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141

Query: 346 QGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405
             H N V   K+ P G L+ S SDD T+K+W      CVH    H   +  + + P+G  
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT- 200

Query: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
                    +A+A  D+TV++WDV     +     H   V  ++F P G YL + S D  
Sbjct: 201 --------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252

Query: 466 VHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCV 509
           + I +   G L+++  G  G    V ++  G+   +  SD  V V
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297



 Score =  104 bits (259), Expect = 2e-22
 Identities = 82/297 (27%), Positives = 127/297 (42%), Gaps = 26/297 (8%)

Query: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
           P ++A    GH+  V    ++P   LLASGS D T RIW     +  G + +   H    
Sbjct: 50  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGESTVFRAH---- 102

Query: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNK 276
                     V S+ + S+G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 103 -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 155

Query: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 215

Query: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
           +   R ++ +Q H+  VN + + P+GN L + S D TLKI  + +   ++ L  H     
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFS 451
           T+ +S TG            AS   D  V +W  +  I  H  +TK   P  ++A S
Sbjct: 276 TVAFSRTGE---------YFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASS 323



 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 15/217 (6%)

Query: 301 KQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDP 359
           ++ F  H      VD+  N    AS S D C+ V  +        F GH + V  + + P
Sbjct: 12  ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 360 TGNLLASCSDDMTLKIW--SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
           +G+LLAS S D T++IW  ++K ++ V   +AH   + ++ +   G             +
Sbjct: 72  SGHLLASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQS---------FVT 120

Query: 418 ASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV 477
           AS D TV++W   R   + +L++H   V    FSPDGR + S S DK V +W+  +   V
Sbjct: 121 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 478 HSYRGTGG-IFEVCWNAAGDKVGASASDGSVCVLDLR 513
           HSY   GG +  V ++ +G  + A+  D +V V D+R
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 61/261 (23%), Positives = 116/261 (44%), Gaps = 11/261 (4%)

Query: 254 KDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 313
           +D +L      H+  +  + ++     + S  +D   ++W         +F  H      
Sbjct: 7   EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66

Query: 314 VDWQ-SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372
           V++  S +  AS S D  + +           F+ HT  V ++ +   G    + SDD T
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126

Query: 373 LKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRG 432
           +K+W+  +   +  L  H   +   K+SP G          ++ SAS D TV+LWD    
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGR---------LIVSASDDKTVKLWDKSSR 177

Query: 433 ICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR-GTGGIFEVCW 491
            C+H+  +H   V  V F P G  +A+   D  V +W+ +T  L+  Y+  +  +  + +
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237

Query: 492 NAAGDKVGASASDGSVCVLDL 512
           + +G+ +  ++SD ++ +LDL
Sbjct: 238 HPSGNYLITASSDSTLKILDL 258


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  116 bits (290), Expect = 6e-26
 Identities = 85/325 (26%), Positives = 137/325 (42%), Gaps = 68/325 (20%)

Query: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
           PP K   L GH S V    ++PV  ++ S S D+T ++W+      +G  +  L+     
Sbjct: 98  PPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE----TGDFERTLK----- 147

Query: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNK 276
           G  D      V  + ++  G LLA+ S D   ++W   G     T+  H   + ++    
Sbjct: 148 GHTD-----SVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202

Query: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKL 336
            G+ I+SA  DKT  +W+  TG                                      
Sbjct: 203 NGDHIVSASRDKTIKMWEVQTGYC------------------------------------ 226

Query: 337 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYT 396
                +KTF GH   V  ++ +  G L+ASCS+D T+++W +    C  +L+ H   +  
Sbjct: 227 -----VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281

Query: 397 IKWSP----------TGPGT-NNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPV 445
           I W+P          TG  T  +      L S S D T+++WDV  G+C+ TL  H   V
Sbjct: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341

Query: 446 YSVAFSPDGRYLASGSFDKCVHIWN 470
             V F   G+++ S + DK + +W+
Sbjct: 342 RGVLFHSGGKFILSCADDKTLRVWD 366



 Score =  104 bits (259), Expect = 2e-22
 Identities = 71/274 (25%), Positives = 127/274 (46%), Gaps = 31/274 (11%)

Query: 262 LGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNN 320
           L  H+ P+  + ++   + ++SA  D T  +WD  TG+ ++    H+    D+ +  S  
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163

Query: 321 TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ 380
             ASCS DM I +        I+T  GH + V+++   P G+ + S S D T+K+W ++ 
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223

Query: 381 DNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTK 440
             CV     H + +  ++  P   GT       ++AS S D TVR+W V    C   L +
Sbjct: 224 GYCVKTFTGHREWVRMVR--PNQDGT-------LIASCSNDQTVRVWVVATKECKAELRE 274

Query: 441 HQEPVYSVAFSPD--------------------GRYLASGSFDKCVHIWNTQTGALVHSY 480
           H+  V  ++++P+                    G +L SGS DK + +W+  TG  + + 
Sbjct: 275 HEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334

Query: 481 RG-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
            G    +  V +++ G  + + A D ++ V D +
Sbjct: 335 VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 94/421 (22%), Positives = 162/421 (38%), Gaps = 66/421 (15%)

Query: 6   DEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALI------SIIQKGLQY 59
           DE+N  +  YL+ +G+  +   F  E+ +   ++N  L    A +      S+I+   + 
Sbjct: 9   DELNRAIADYLRSNGYEEAYSVFKKEAEL---DVNEELDKKYAGLLEKKWTSVIRLQKKV 65

Query: 60  VEAEVSINEDGTLF-DGRPIESLSLIDAVMPDVVQTRQ-QAYRDKLAQQQAAAAAAAAAA 117
           +E E  +NE    F  G P+         +P   +      +R  + +       +   +
Sbjct: 66  MELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVS 125

Query: 118 ASQQGSAK-------NGENTANGEENGAHTIANNHTDMM----EVDGDVEIPPNKAV--- 163
           AS+  + K       + E T  G  +    I+ +H+  +      D  +++   +     
Sbjct: 126 ASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECI 185

Query: 164 -VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222
             + GH+  V   A  P  D + S S D T ++W   E  T    +    H  RE  + V
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW---EVQTGYCVKTFTGH--REWVRMV 240

Query: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIW---TKDGNLASTLGQHKGPIFALKW----- 274
             N+D         GTL+A+ S D   R+W   TK+    + L +H+  +  + W     
Sbjct: 241 RPNQD---------GTLIASCSNDQTVRVWVVATKE--CKAELREHEHVVECISWAPESS 289

Query: 275 ---------------NKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN 319
                           K G F+LS   DKT  +WD  TG        H      V + S 
Sbjct: 290 YSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSG 349

Query: 320 NTFA-SCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSM 378
             F  SC+ D  + V      R +KT   H + V ++ +  T   + + S D T+K+W  
Sbjct: 350 GKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409

Query: 379 K 379
           +
Sbjct: 410 R 410



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 18/79 (22%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 436 HTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAA 494
           + L+ H+ PV  V F P    + S S D  + +W+ +TG    + +G T  + ++ ++ +
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161

Query: 495 GDKVGASASDGSVCVLDLR 513
           G  + + ++D ++ + D +
Sbjct: 162 GKLLASCSADMTIKLWDFQ 180


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  114 bits (286), Expect = 2e-25
 Identities = 74/280 (26%), Positives = 130/280 (46%), Gaps = 21/280 (7%)

Query: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 330

Query: 296 HTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 355
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 389

Query: 356 KWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLML 415
           ++D  G  + S + D  +K+W  + + C+H LQ H   +Y++++             + +
Sbjct: 390 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 436

Query: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGA 475
            S S D+++R+WDV+ G CIHTLT HQ     +    +   L SG+ D  V IW+ +TG 
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 494

Query: 476 LVHSYRGTG--GIFEVCWNAAGDKVGASASDGSVCVLDLR 513
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 495 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 534



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 61/311 (19%)

Query: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           VL+GH+  V  C      + + SGS D+T ++W       S  T   LR  +   G    
Sbjct: 257 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVW-------SAVTGKCLRTLVGHTGGV-- 306

Query: 224 SNKDVTSLDWNSE--GTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKKGNF 280
                    W+S+    ++ +GS D   ++W  + G    TL  H   +  +  ++K   
Sbjct: 307 ---------WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-- 355

Query: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
           ++S   D T  +WD  TG+       H A    V +       S + D  + V     + 
Sbjct: 356 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETET 414

Query: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK-------- 392
            + T QGHTN V ++++D  G  + S S D ++++W ++  NC+H L  H          
Sbjct: 415 CLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 472

Query: 393 -------------EIYTIKWSPT-----GPGTNNP-------NANLMLASASFDSTVRLW 427
                        +I+ IK         GP  +         N N ++ S+  D TV+LW
Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD-DGTVKLW 531

Query: 428 DVDRGICIHTL 438
           D+  G  I  L
Sbjct: 532 DLKTGEFIRNL 542


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  114 bits (286), Expect = 2e-25
 Identities = 74/280 (26%), Positives = 130/280 (46%), Gaps = 21/280 (7%)

Query: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448

Query: 296 HTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 355
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507

Query: 356 KWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLML 415
           ++D  G  + S + D  +K+W  + + C+H LQ H   +Y++++             + +
Sbjct: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554

Query: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGA 475
            S S D+++R+WDV+ G CIHTLT HQ     +    +   L SG+ D  V IW+ +TG 
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612

Query: 476 LVHSYRGTG--GIFEVCWNAAGDKVGASASDGSVCVLDLR 513
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 61/311 (19%)

Query: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           VL+GH+  V  C      + + SGS D+T ++W       S  T   LR  +   G    
Sbjct: 375 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVW-------SAVTGKCLRTLVGHTGGV-- 424

Query: 224 SNKDVTSLDWNSE--GTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKKGNF 280
                    W+S+    ++ +GS D   ++W  + G    TL  H   +  +  ++K   
Sbjct: 425 ---------WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-- 473

Query: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
           ++S   D T  +WD  TG+       H A    V +       S + D  + V     + 
Sbjct: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETET 532

Query: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK-------- 392
            + T QGHTN V ++++D  G  + S S D ++++W ++  NC+H L  H          
Sbjct: 533 CLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 590

Query: 393 -------------EIYTIKWSPT-----GPGTNNP-------NANLMLASASFDSTVRLW 427
                        +I+ IK         GP  +         N N ++ S+  D TV+LW
Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD-DGTVKLW 649

Query: 428 DVDRGICIHTL 438
           D+  G  I  L
Sbjct: 650 DLKTGEFIRNL 660


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  114 bits (286), Expect = 2e-25
 Identities = 74/280 (26%), Positives = 130/280 (46%), Gaps = 21/280 (7%)

Query: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 368

Query: 296 HTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 355
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 427

Query: 356 KWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLML 415
           ++D  G  + S + D  +K+W  + + C+H LQ H   +Y++++             + +
Sbjct: 428 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 474

Query: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGA 475
            S S D+++R+WDV+ G CIHTLT HQ     +    +   L SG+ D  V IW+ +TG 
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 532

Query: 476 LVHSYRGTG--GIFEVCWNAAGDKVGASASDGSVCVLDLR 513
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 533 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 572



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 61/311 (19%)

Query: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           VL+GH+  V  C      + + SGS D+T ++W       S  T   LR  +   G    
Sbjct: 295 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVW-------SAVTGKCLRTLVGHTGGV-- 344

Query: 224 SNKDVTSLDWNSE--GTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKKGNF 280
                    W+S+    ++ +GS D   ++W  + G    TL  H   +  +  ++K   
Sbjct: 345 ---------WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-- 393

Query: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340
           ++S   D T  +WD  TG+       H A    V +       S + D  + V     + 
Sbjct: 394 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETET 452

Query: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK-------- 392
            + T QGHTN V ++++D  G  + S S D ++++W ++  NC+H L  H          
Sbjct: 453 CLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 510

Query: 393 -------------EIYTIKWSPT-----GPGTNNP-------NANLMLASASFDSTVRLW 427
                        +I+ IK         GP  +         N N ++ S+  D TV+LW
Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD-DGTVKLW 569

Query: 428 DVDRGICIHTL 438
           D+  G  I  L
Sbjct: 570 DLKTGEFIRNL 580


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  110 bits (275), Expect = 3e-24
 Identities = 72/269 (26%), Positives = 123/269 (45%), Gaps = 15/269 (5%)

Query: 227 DVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAG 285
           +V S  ++ +G +L TGS DG    W T+ G L   LG H GP+   +++  G+   SA 
Sbjct: 23  EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82

Query: 286 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCKLGQDRPIKT 344
            D T  +WD    +  +    H      V +  ++   AS   D  + +  +   + ++ 
Sbjct: 83  CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142

Query: 345 FQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCV---HDLQAHNKEIYTIKWSP 401
             GH + + +  + PT N LA+ S D T+ IW ++          L+ H+  I  + +S 
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202

Query: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGS 461
           +G          +LAS S+D T+ +W       +  L  H   V S+AFSPD  +LAS  
Sbjct: 203 SG----------LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAG 252

Query: 462 FDKCVHIWNTQTGALVHSYRGTGGIFEVC 490
           + + V +W+  TG  + + +G   +   C
Sbjct: 253 YSRMVKVWDCNTGKCLETLKGVLDVAHTC 281



 Score =  100 bits (249), Expect = 3e-21
 Identities = 82/302 (27%), Positives = 134/302 (44%), Gaps = 29/302 (9%)

Query: 168 HESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKD 227
           H  EV   A++P   +L +GS D     W       + S QL+ R     GG   P    
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE------TRSGQLLWRL----GGHTGP---- 65

Query: 228 VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 286
           V    ++ +G L A+ S D   R+W          L  H+  +  + ++     + S G 
Sbjct: 66  VKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGW 125

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NTFASCSTDMCIHVCKLGQDRPIKTF 345
           DK  ++WD  +G+  +    H       D+    N  A+ S D  +H+  L    P  + 
Sbjct: 126 DKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSH 185

Query: 346 Q---GHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
           Q   GH+  ++ + +  +G LLAS S D T+ IW     + +  L+ H   + +I +SP 
Sbjct: 186 QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244

Query: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSF 462
                     L LASA +   V++WD + G C+ TL    +  ++ AF+PDG+ L SG+ 
Sbjct: 245 ---------ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295

Query: 463 DK 464
           D+
Sbjct: 296 DQ 297



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 59/175 (33%), Positives = 88/175 (50%), Gaps = 10/175 (5%)

Query: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
           R +K F  H  EVN+  + P G +L + S+D  +  W  +    +  L  H   +   ++
Sbjct: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF 71

Query: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459
           SP G          + ASAS D TVRLWDV R  C+  L  HQ  V +V+FSPD R LAS
Sbjct: 72  SPDGH---------LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS 122

Query: 460 GSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 513
           G +DK V +W+ Q+G ++    G    I    ++   + +   + D +V + DLR
Sbjct: 123 GGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 58/224 (25%), Positives = 100/224 (44%), Gaps = 14/224 (6%)

Query: 263 GQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNT 321
           GQH G + +  ++  G  +L+   D     W+  +G+   +   H+ P     +    + 
Sbjct: 18  GQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHL 77

Query: 322 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD 381
           FAS S D  + +  + + + ++  +GH   V  + + P    LAS   D  + +W ++  
Sbjct: 78  FASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137

Query: 382 NCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWD---VDRGICIHTL 438
             +  L  H   I +  +SPT            LA+ S+DSTV +WD   V   +    L
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVN---------CLATGSWDSTVHIWDLRMVTPAVSHQAL 188

Query: 439 TKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
             H   +  + +S  G  LASGS+DK +HIW   T +L+   +G
Sbjct: 189 EGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKG 231



 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 60/245 (24%), Positives = 102/245 (41%), Gaps = 22/245 (8%)

Query: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIR--EGGQDV 222
           L GH   V  C ++P   L AS S D T R+W+++              C+R  +G Q  
Sbjct: 59  LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR-----------AKCLRVLKGHQ-- 105

Query: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFI 281
              + V ++ ++ +   LA+G +D    +W  + G +   L  H+  I +  ++   N +
Sbjct: 106 ---RSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL 162

Query: 282 LSAGVDKTTIIWDAH---TGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQ 338
            +   D T  IWD        + Q    HSA    + + ++   AS S D  IH+ K   
Sbjct: 163 ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTT 222

Query: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIK 398
              +   +GH   V +I + P    LAS      +K+W      C+  L+      +T  
Sbjct: 223 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCA 282

Query: 399 WSPTG 403
           ++P G
Sbjct: 283 FTPDG 287



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 40/139 (28%), Positives = 70/139 (50%), Gaps = 17/139 (12%)

Query: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
           +L GH   +    ++P  + LA+GS DST  IW+L   + + S Q +  H          
Sbjct: 142 LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH---------- 191

Query: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALK---WNKKGNF 280
            + +++ L +++ G LLA+GS+D    IW      +S L Q KG +  +K   ++    +
Sbjct: 192 -SANISCLCYSASG-LLASGSWDKTIHIWKP--TTSSLLIQLKGHVTWVKSIAFSPDELW 247

Query: 281 ILSAGVDKTTIIWDAHTGE 299
           + SAG  +   +WD +TG+
Sbjct: 248 LASAGYSRMVKVWDCNTGK 266


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  106 bits (264), Expect = 6e-23
 Identities = 70/267 (26%), Positives = 115/267 (43%), Gaps = 12/267 (4%)

Query: 246 DGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQF 304
           D    +W  K  + A     HK  +  + ++  G+ + S   DKT  IW  +       F
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 305 PFHSAPALDVDWQSNN-TFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNL 363
             H+A    V + S+  +F + S D  + V    + + + +   H N V   K+ P G L
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 364 LASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDST 423
           + S SDD T+K+W      CVH    H   +  + + P+G           +A+A  D+T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT---------CIAAAGMDNT 172

Query: 424 VRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG- 482
           V++WDV     +     H   V  ++F P G YL + S D  + I +   G L+++  G 
Sbjct: 173 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232

Query: 483 TGGIFEVCWNAAGDKVGASASDGSVCV 509
            G    V ++  G+   +  SD  V V
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMV 259



 Score =  104 bits (259), Expect = 2e-22
 Identities = 82/297 (27%), Positives = 127/297 (42%), Gaps = 26/297 (8%)

Query: 158 PPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIRE 217
           P ++A    GH+  V    ++P   LLASGS D T RIW     +  G + +   H    
Sbjct: 12  PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGESTVFRAH---- 64

Query: 218 GGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNK 276
                     V S+ + S+G    T S D   ++W T       +L QH   +   K++ 
Sbjct: 65  -------TATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117

Query: 277 KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT-FASCSTDMCIHVCK 335
            G  I+SA  DKT  +WD  + E    +  H      VD+  + T  A+   D  + V  
Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177

Query: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395
           +   R ++ +Q H+  VN + + P+GN L + S D TLKI  + +   ++ L  H     
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237

Query: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFS 451
           T+ +S TG            AS   D  V +W  +  I  H  +TK   P  ++A S
Sbjct: 238 TVAFSRTGE---------YFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASS 285



 Score =  102 bits (253), Expect = 1e-21
 Identities = 69/259 (26%), Positives = 122/259 (47%), Gaps = 23/259 (8%)

Query: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQ-HKGPIFALKWNKKGNFILSAGV 286
           VT ++++  G LLA+GS D   RIW  +    ST+ + H   + ++ +   G   ++A  
Sbjct: 26  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85

Query: 287 DKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-------SCSTDMCIHVCKLGQD 339
           DKT  +W  H    +Q+F F  +    ++W     F+       S S D  + +      
Sbjct: 86  DKTVKVWATH----RQKFLFSLSQ--HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139

Query: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
             + ++  H   V  + + P+G  +A+   D T+K+W ++    +   Q H+  +  + +
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199

Query: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459
            P+G           L +AS DST+++ D+  G  ++TL  HQ P  +VAFS  G Y AS
Sbjct: 200 HPSGN---------YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 250

Query: 460 GSFDKCVHIWNTQTGALVH 478
           G  D+ V +W +    + H
Sbjct: 251 GGSDEQVMVWKSNFDIVDH 269



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 14/189 (7%)

Query: 328 DMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW--SMKQDNCVH 385
           D C+ V  +        F GH + V  + + P+G+LLAS S D T++IW  ++K ++ V 
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60

Query: 386 DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPV 445
             +AH   + ++ +   G             +AS D TV++W   R   + +L++H   V
Sbjct: 61  -FRAHTATVRSVHFCSDGQS---------FVTASDDKTVKVWATHRQKFLFSLSQHINWV 110

Query: 446 YSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG-IFEVCWNAAGDKVGASASD 504
               FSPDGR + S S DK V +W+  +   VHSY   GG +  V ++ +G  + A+  D
Sbjct: 111 RCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMD 170

Query: 505 GSVCVLDLR 513
            +V V D+R
Sbjct: 171 NTVKVWDVR 179



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 57/229 (24%), Positives = 104/229 (45%), Gaps = 11/229 (4%)

Query: 286 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIKT 344
           +D   ++W         +F  H      V++  S +  AS S D  + +           
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60

Query: 345 FQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGP 404
           F+ HT  V ++ +   G    + SDD T+K+W+  +   +  L  H   +   K+SP G 
Sbjct: 61  FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 405 GTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDK 464
                    ++ SAS D TV+LWD     C+H+  +H   V  V F P G  +A+   D 
Sbjct: 121 ---------LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDN 171

Query: 465 CVHIWNTQTGALVHSYR-GTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
            V +W+ +T  L+  Y+  +  +  + ++ +G+ +  ++SD ++ +LDL
Sbjct: 172 TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDL 220


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  106 bits (264), Expect = 6e-23
 Identities = 74/309 (23%), Positives = 138/309 (44%), Gaps = 24/309 (7%)

Query: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS-- 224
           G +  +  C ++P S +LA+       ++W++ + +        L H +R    +V +  
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCN--------LLHTLRGHNTNVGAIV 280

Query: 225 --NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNL-ASTLGQHKGPIFALKWNKKGNFI 281
              K   SLD   +   LA+ + DG  ++W+ D +   + +  H   +  + W+  G F+
Sbjct: 281 FHPKSTVSLD--PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFL 338

Query: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCS-TDMCIHVCKLGQDR 340
            +   D++  +WD    E       HS    D+ +  + + A     D    V  L   R
Sbjct: 339 GTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGR 398

Query: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWS 400
            I   +GH  E+  I + P G  +A+ S D T K+W ++Q  CV+ + AH   +  +K+ 
Sbjct: 399 CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458

Query: 401 PTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASG 460
           P        + N +L  A +D+T ++W       + TL  H+  V  +  S DG+ +A+ 
Sbjct: 459 PI-------HGNFLLTGA-YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 510

Query: 461 SFDKCVHIW 469
           S+D+   +W
Sbjct: 511 SYDRTFKLW 519



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 64/259 (24%), Positives = 113/259 (43%), Gaps = 20/259 (7%)

Query: 222 VPSNKDVTSLDWNSEGTLLATGSYDGFARIWT-KDGNLASTLGQHKGPIFALKWNKKGNF 280
           +  ++ ++   ++    +LAT  + G  ++W+  D NL  TL  H   + A+ ++ K   
Sbjct: 228 IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTV 287

Query: 281 IL--------SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCST-DMCI 331
            L        S   D +  +W   + E       H+     V W  +  F   +  D   
Sbjct: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347

Query: 332 HVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHN 391
            +  L     I   +GH+  V  I +   G+L  +   D   ++W ++   C+  L+ H 
Sbjct: 348 RLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL 407

Query: 392 KEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS 451
           KEIY I +SP G           +A+ S D+T ++WD+ +  C++T+  HQ  V  V F 
Sbjct: 408 KEIYGINFSPNG---------YHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFE 458

Query: 452 P-DGRYLASGSFDKCVHIW 469
           P  G +L +G++D    IW
Sbjct: 459 PIHGNFLLTGAYDNTAKIW 477



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 49/182 (26%), Positives = 82/182 (45%), Gaps = 18/182 (9%)

Query: 342 IKTFQGHTNEVNAIKWDPTGNL--------LASCSDDMTLKIWSMKQDNCVHDLQAHNKE 393
           + T +GH   V AI + P   +        LASC+ D ++K+WS+  D  V D++ H   
Sbjct: 266 LHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVR 325

Query: 394 IYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPD 453
           +  + W P+G           L +  +D + RLWD++    I     H   VY +AF  D
Sbjct: 326 VARVMWHPSGR---------FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD 376

Query: 454 GRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
           G    +G  D    +W+ +TG  +    G    I+ + ++  G  +   + D +  V DL
Sbjct: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436

Query: 513 RK 514
           R+
Sbjct: 437 RQ 438



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 58/244 (23%), Positives = 95/244 (38%), Gaps = 22/244 (9%)

Query: 136 NGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARI 195
           N A   A+    +  +D D  +       + GH   V    W+P    L +   D + R+
Sbjct: 295 NLASCAADGSVKLWSLDSDEPVAD-----IEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349

Query: 196 WNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIW-TK 254
           W+L         Q  + H  +EG      +  V  + ++ +G+L  TG  D F R+W  +
Sbjct: 350 WDL-------EAQEEILH--QEG-----HSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR 395

Query: 255 DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDV 314
            G     L  H   I+ + ++  G  I +   D T  +WD          P H      V
Sbjct: 396 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV 455

Query: 315 DWQ--SNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMT 372
            ++    N   + + D    +       P+KT  GH  +V  +     G L+A+CS D T
Sbjct: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515

Query: 373 LKIW 376
            K+W
Sbjct: 516 FKLW 519



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 40/134 (29%), Positives = 68/134 (50%), Gaps = 18/134 (13%)

Query: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
           L GH  E++   ++P    +A+GSGD+T ++W+L +           R C+      +P+
Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ-----------RRCV----YTIPA 447

Query: 225 NKD-VTSLDWNS-EGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFI 281
           +++ VT + +    G  L TG+YD  A+IWT  G +   TL  H+G +  L  +  G  I
Sbjct: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLI 507

Query: 282 LSAGVDKTTIIWDA 295
            +   D+T  +W A
Sbjct: 508 ATCSYDRTFKLWMA 521


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,521,652
Number of Sequences: 37866
Number of extensions: 929284
Number of successful extensions: 8332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 273
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3778
Number of HSP's gapped (non-prelim): 1986
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.