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Search of human proteins with 19743909
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19743909 RAR-related orphan receptor C isoform a [Homo
sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens] 1059 0.0
gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens] 1013 0.0
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 471 e-133
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 456 e-128
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 456 e-128
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 456 e-128
gi|19743907 RAR-related orphan receptor B [Homo sapiens] 434 e-121
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 220 2e-57
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 130 4e-30
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 130 4e-30
gi|116284373 peroxisome proliferative activated receptor gamma i... 117 3e-26
gi|20336229 peroxisome proliferative activated receptor gamma is... 117 3e-26
gi|116284368 peroxisome proliferative activated receptor gamma i... 117 3e-26
gi|116284370 peroxisome proliferative activated receptor gamma i... 117 3e-26
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 116 6e-26
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 115 1e-25
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 115 1e-25
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 115 1e-25
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 114 2e-25
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 113 5e-25
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 113 5e-25
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 113 5e-25
gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Hom... 112 6e-25
gi|189491739 nuclear receptor subfamily 2, group C, member 1 iso... 112 6e-25
gi|11415052 retinoid X receptor, beta [Homo sapiens] 111 1e-24
gi|50348666 peroxisome proliferative activated receptor, alpha [... 111 2e-24
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 111 2e-24
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 110 2e-24
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 109 5e-24
gi|27894359 nuclear receptor subfamily 4, group A, member 3 isof... 109 5e-24
>gi|19743909 RAR-related orphan receptor C isoform a [Homo sapiens]
Length = 518
Score = 1059 bits (2739), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR 60
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
Sbjct: 1 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR 60
Query: 61 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK 120
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
Sbjct: 61 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK 120
Query: 121 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS 180
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
Sbjct: 121 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS 180
Query: 181 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG 240
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
Sbjct: 181 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG 240
Query: 241 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF 300
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
Sbjct: 241 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF 300
Query: 301 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV 360
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
Sbjct: 301 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV 360
Query: 361 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY 420
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
Sbjct: 361 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY 420
Query: 421 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV 480
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
Sbjct: 421 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV 480
Query: 481 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 518
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Sbjct: 481 ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 518
>gi|48255918 RAR-related orphan receptor C isoform b [Homo sapiens]
Length = 497
Score = 1013 bits (2619), Expect = 0.0
Identities = 494/495 (99%), Positives = 495/495 (100%)
Query: 24 SQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC 83
+QIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC
Sbjct: 3 TQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC 62
Query: 84 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG 143
QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG
Sbjct: 63 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG 122
Query: 144 ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE 203
ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE
Sbjct: 123 ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE 182
Query: 204 YSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP 263
YSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP
Sbjct: 183 YSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP 242
Query: 264 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHH 323
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHH
Sbjct: 243 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHH 302
Query: 324 LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYG 383
LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYG
Sbjct: 303 LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYG 362
Query: 384 GMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQ 443
GMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQ
Sbjct: 363 GMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQ 422
Query: 444 YNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYK 503
YNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYK
Sbjct: 423 YNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYK 482
Query: 504 ELFSTETESPVGLSK 518
ELFSTETESPVGLSK
Sbjct: 483 ELFSTETESPVGLSK 497
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 471 bits (1211), Expect = e-133
Identities = 251/508 (49%), Positives = 326/508 (64%), Gaps = 41/508 (8%)
Query: 6 QRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAY 65
Q SR + KKTHTSQIE+IPCKICGDKSSGIHYGVITCEGCKGFFRRSQ+ NA Y
Sbjct: 48 QSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATY 107
Query: 66 SCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQR 125
SC RQ+NC IDRTSRNRCQHCRLQKCLA+GMSRDAVKFGRMSKKQRDSL+AEVQK Q+
Sbjct: 108 SCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQ 167
Query: 126 QQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPS 185
QQ+ + Q P + P P + GL + +
Sbjct: 168 QQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELHDDLSN 202
Query: 186 YSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELG 245
Y + ++PE KA+ S + Q +PD+ GL + + +
Sbjct: 203 YIDG--------------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYT 248
Query: 246 QGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEV 305
+ SF + +P S+ E+EHL Q++ KS+ ETCQ E+L + F +EE+
Sbjct: 249 PASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEI 308
Query: 306 TGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM 365
YQ K MW+ CA +TEAIQYVVEFAKR+ GFMELCQNDQIVLLKAG++EVV +RM
Sbjct: 309 ENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRM 368
Query: 366 CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVL 425
CRA+++ N TV+F+GKY ++F++LGC + IS +F+F SL ++H +EDEIAL++A VL
Sbjct: 369 CRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVL 428
Query: 426 INAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQ-SILAKLPPK-GKLRSLCSQHVERL 483
++A R LQEK K+E+LQ ++LA H L K HR+ IL KL K LR+LC +H E+L
Sbjct: 429 MSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKL 488
Query: 484 QIFQHLHPIVVQAAFPPLYKELFSTETE 511
F+ ++P +V+ FPPLYKELF++E E
Sbjct: 489 MAFKAIYPDIVRLHFPPLYKELFTSEFE 516
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 456 bits (1173), Expect = e-128
Identities = 245/499 (49%), Positives = 322/499 (64%), Gaps = 44/499 (8%)
Query: 15 LLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCP 74
++AA K +QIE+IPCKICGDKSSGIHYGVITCEGCKGFFRRSQ+ NA YSC RQ+NC
Sbjct: 5 VIAAMK---AQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCL 61
Query: 75 IDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVV 134
IDRTSRNRCQHCRLQKCLA+GMSRDAVKFGRMSKKQRDSL+AEVQK Q+QQ+ +
Sbjct: 62 IDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQ--- 118
Query: 135 KTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAG 194
Q P + P P + GL + +Y +
Sbjct: 119 ----------------------QQPGEAEPLTPTYNISANGLTELHDDLSNYIDG----- 151
Query: 195 LNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSP 254
++PE KA+ S + Q +PD+ GL + + + +
Sbjct: 152 ---------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYC 202
Query: 255 SFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW 314
SF + +P S+ E+EHL Q++ KS+ ETCQ E+L + F +EE+ YQ K
Sbjct: 203 SFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQRE 262
Query: 315 EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNR 374
MW+ CA +TEAIQYVVEFAKR+ GFMELCQNDQIVLLKAG++EVV +RMCRA+++ N
Sbjct: 263 VMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNN 322
Query: 375 TVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQ 434
TV+F+GKY ++F++LGC + IS +F+F SL ++H +EDEIAL++A VL++A R LQ
Sbjct: 323 TVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQ 382
Query: 435 EKRKVEQLQYNLELAFHHHLCKTHRQ-SILAKLPPK-GKLRSLCSQHVERLQIFQHLHPI 492
EK K+E+LQ ++LA H L K HR+ IL KL K LR+LC +H E+L F+ ++P
Sbjct: 383 EKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPD 442
Query: 493 VVQAAFPPLYKELFSTETE 511
+V+ FPPLYKELF++E E
Sbjct: 443 IVRLHFPPLYKELFTSEFE 461
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 456 bits (1172), Expect = e-128
Identities = 242/490 (49%), Positives = 317/490 (64%), Gaps = 41/490 (8%)
Query: 24 SQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC 83
+QIE+IPCKICGDKSSGIHYGVITCEGCKGFFRRSQ+ NA YSC RQ+NC IDRTSRNRC
Sbjct: 91 AQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRC 150
Query: 84 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG 143
QHCRLQKCLA+GMSRDAVKFGRMSKKQRDSL+AEVQK Q+QQ+ +
Sbjct: 151 QHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQ------------ 198
Query: 144 ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE 203
Q P + P P + GL + +Y +
Sbjct: 199 -------------QQPGEAEPLTPTYNISANGLTELHDDLSNYIDG-------------- 231
Query: 204 YSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP 263
++PE KA+ S + Q +PD+ GL + + + + SF + +P
Sbjct: 232 HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSP 291
Query: 264 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHH 323
S+ E+EHL Q++ KS+ ETCQ E+L + F +EE+ YQ K MW+ CA
Sbjct: 292 TVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIK 351
Query: 324 LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYG 383
+TEAIQYVVEFAKR+ GFMELCQNDQIVLLKAG++EVV +RMCRA+++ N TV+F+GKY
Sbjct: 352 ITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYA 411
Query: 384 GMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQ 443
++F++LGC + IS +F+F SL ++H +EDEIAL++A VL++A R LQEK K+E+LQ
Sbjct: 412 SPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQ 471
Query: 444 YNLELAFHHHLCKTHRQ-SILAKLPPK-GKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL 501
++LA H L K HR+ IL KL K LR+LC +H E+L F+ ++P +V+ FPPL
Sbjct: 472 QKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPL 531
Query: 502 YKELFSTETE 511
YKELF++E E
Sbjct: 532 YKELFTSEFE 541
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 456 bits (1172), Expect = e-128
Identities = 242/490 (49%), Positives = 317/490 (64%), Gaps = 41/490 (8%)
Query: 24 SQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC 83
+QIE+IPCKICGDKSSGIHYGVITCEGCKGFFRRSQ+ NA YSC RQ+NC IDRTSRNRC
Sbjct: 99 AQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRC 158
Query: 84 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG 143
QHCRLQKCLA+GMSRDAVKFGRMSKKQRDSL+AEVQK Q+QQ+ +
Sbjct: 159 QHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQ------------ 206
Query: 144 ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE 203
Q P + P P + GL + +Y +
Sbjct: 207 -------------QQPGEAEPLTPTYNISANGLTELHDDLSNYIDG-------------- 239
Query: 204 YSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAP 263
++PE KA+ S + Q +PD+ GL + + + + SF + +P
Sbjct: 240 HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSP 299
Query: 264 YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHH 323
S+ E+EHL Q++ KS+ ETCQ E+L + F +EE+ YQ K MW+ CA
Sbjct: 300 TVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIK 359
Query: 324 LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYG 383
+TEAIQYVVEFAKR+ GFMELCQNDQIVLLKAG++EVV +RMCRA+++ N TV+F+GKY
Sbjct: 360 ITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYA 419
Query: 384 GMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQ 443
++F++LGC + IS +F+F SL ++H +EDEIAL++A VL++A R LQEK K+E+LQ
Sbjct: 420 SPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQ 479
Query: 444 YNLELAFHHHLCKTHRQ-SILAKLPPK-GKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL 501
++LA H L K HR+ IL KL K LR+LC +H E+L F+ ++P +V+ FPPL
Sbjct: 480 QKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPL 539
Query: 502 YKELFSTETE 511
YKELF++E E
Sbjct: 540 YKELFTSEFE 549
>gi|19743907 RAR-related orphan receptor B [Homo sapiens]
Length = 459
Score = 434 bits (1115), Expect = e-121
Identities = 240/495 (48%), Positives = 326/495 (65%), Gaps = 53/495 (10%)
Query: 24 SQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRC 83
+QIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQ+ NA+YSC RQ+NC IDRT+RNRC
Sbjct: 3 AQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRC 62
Query: 84 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQG 143
QHCRLQKCLALGMSRDAVKFGRMSKKQRDSL+AEVQK Q+ Q+Q+Q+ +G
Sbjct: 63 QHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQ------SGEAE 116
Query: 144 ADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLE 203
A Y+ + +G L + + SG+ Y+N H+
Sbjct: 117 ALARVYSSSISNGLSNLNN---------------ETSGT---YANG-----------HVI 147
Query: 204 YSPERGKAEGRESFYSTGS-QLTPDRCGLRF---EEHRHPGLGELGQGPDSYGSPSFRST 259
P K+EG +Y+ S Q +PD+ GL ++ + + +L P+ + SF +
Sbjct: 148 DLP---KSEG---YYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNG 201
Query: 260 PEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWER 319
AP ++TEI+ + Q++ KS+ ETCQ +E+L + + EE+ YQ KS +W++
Sbjct: 202 QLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQ 261
Query: 320 CAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFE 379
CA +T AIQYVVEFAKR++GFMELCQNDQI+LLK+G +EVVLVRMCRA+N N TV FE
Sbjct: 262 CAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFE 321
Query: 380 GKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKV 439
GKYGGM++F+ALG +L++ FDF+ +L +L +E+EIAL+++ VLI+ R L E RKV
Sbjct: 322 GKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKV 381
Query: 440 EQLQYNLELAFHHHLCKTHRQ-----SILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVV 494
++LQ + A H + K H ++AK+P + ++C+ H E+LQ+F+ HP +V
Sbjct: 382 QKLQEKIYFALQHVIQKNHLDDETLAKLIAKIP---TITAVCNLHGEKLQVFKQSHPEIV 438
Query: 495 QAAFPPLYKELFSTE 509
FPPLYKELF+ +
Sbjct: 439 NTLFPPLYKELFNPD 453
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 220 bits (561), Expect = 2e-57
Identities = 163/499 (32%), Positives = 245/499 (49%), Gaps = 56/499 (11%)
Query: 28 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 86
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 129 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQC 188
Query: 87 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK--QLQQRQQQQQEPVVKTP------- 137
R +KCL++GMSRDAV+FGR+ K+++ + AE+Q L Q Q P+ +P
Sbjct: 189 RFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPG 248
Query: 138 -----PAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAK 192
P A L P P S P + +A +Y+++ K
Sbjct: 249 PMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHD--K 306
Query: 193 AGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSY- 251
G + + + ++ A + + G P+ + + L L Q P SY
Sbjct: 307 LGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYP 366
Query: 252 ---------------GSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQR 296
S R P YA+ ++ S R+ + LL
Sbjct: 367 PTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEG-----KAPANSPRQGNSKNV--LLACP 419
Query: 297 SNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAG 356
N++ G +++ E+WE + T A++ VVEFAK + GF +L Q+DQ+ LLKAG
Sbjct: 420 MNMYPH----GRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAG 475
Query: 357 AMEVVLVRMCRAYNADNRTVFFEGK--YGGMELFRALGCSELISSIFDFSHSLSALHFSE 414
EV++VR +N ++TV F + Y EL A+G +L+S++FDFS L++L +E
Sbjct: 476 TFEVLMVRFASLFNVKDQTVMFLSRTTYSLQEL-GAMGMGDLLSAMFDFSEKLNSLALTE 534
Query: 415 DEIALYTALVLINAHRPGLQEKRKVEQLQYNL-----ELAFHHHLCKTHR-QSILAKLPP 468
+E+ L+TA+VL++A R G++ VEQLQ L L + +T R +L KLP
Sbjct: 535 EELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLP- 593
Query: 469 KGKLRSLCSQHVERLQIFQ 487
LR+L + H E+L F+
Sbjct: 594 --DLRTLNNMHSEKLLSFR 610
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 321 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 380
Query: 371 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 381 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 440
Query: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 486
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 441 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 500
Query: 487 QHLHP 491
+ +HP
Sbjct: 501 K-VHP 504
Score = 122 bits (306), Expect = 8e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 28 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 86
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 25 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 84
Query: 87 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 129
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 85 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 130 bits (326), Expect = 4e-30
Identities = 78/185 (42%), Positives = 114/185 (61%), Gaps = 5/185 (2%)
Query: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
KS E+WE + T A++ VVEFAKR+ GF +L Q+DQ+ LLKAG EV++VR ++
Sbjct: 396 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD 455
Query: 371 ADNRTV-FFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
A RTV F GK ++ ++G +L++S+F+FS L+AL S++E++L+TA+VL++A
Sbjct: 456 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD 515
Query: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIF 486
R G++ VE LQ L A + K H SI KL K LRSL + H E L F
Sbjct: 516 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF 575
Query: 487 QHLHP 491
+ +HP
Sbjct: 576 K-VHP 579
Score = 122 bits (306), Expect = 8e-28
Identities = 54/103 (52%), Positives = 73/103 (70%), Gaps = 1/103 (0%)
Query: 28 VIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYS-CTRQQNCPIDRTSRNRCQHC 86
V+ CK+CGD +SG HYGV CEGCKGFFRRS + N Y C + +NC I R +RNRCQ C
Sbjct: 100 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQC 159
Query: 87 RLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQ 129
R +KCL++GMSRDAV+FGR+ K+++ + E+Q ++ Q
Sbjct: 160 RFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 117 bits (293), Expect = 3e-26
Identities = 51/102 (50%), Positives = 71/102 (69%), Gaps = 1/102 (0%)
Query: 23 TSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNR 82
++ + I C++CGDK+SG HYGV CEGCKGFFRR+ R Y NC I + SRN+
Sbjct: 103 SNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC-DLNCRIHKKSRNK 161
Query: 83 CQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQ 124
CQ+CR QKCLA+GMS +A++FGRM + +++ L AE+ + Q
Sbjct: 162 CQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQ 203
Score = 89.0 bits (219), Expect = 1e-17
Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 16/202 (7%)
Query: 316 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT 375
+++ C EA+Q + E+AK + GF+ L NDQ+ LLK G E++ + N D
Sbjct: 281 IFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL 340
Query: 376 VFFEGKYGGMELFRAL--GCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGL 433
+ + E ++L + + F+F+ +AL + ++A++ A+++++ RPGL
Sbjct: 341 ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL 400
Query: 434 QEKRKVEQLQYNLELAFHHHLCKTHRQS--ILAKLPPK-GKLRSLCSQHVERLQIFQ--- 487
+ +E +Q NL A L H +S + AKL K LR + ++HV+ LQ+ +
Sbjct: 401 LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE 460
Query: 488 ---HLHPIVVQAAFPPLYKELF 506
LHP++ + +YK+L+
Sbjct: 461 TDMSLHPLLQE-----IYKDLY 477
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 117 bits (293), Expect = 3e-26
Identities = 51/102 (50%), Positives = 71/102 (69%), Gaps = 1/102 (0%)
Query: 23 TSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNR 82
++ + I C++CGDK+SG HYGV CEGCKGFFRR+ R Y NC I + SRN+
Sbjct: 131 SNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC-DLNCRIHKKSRNK 189
Query: 83 CQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQ 124
CQ+CR QKCLA+GMS +A++FGRM + +++ L AE+ + Q
Sbjct: 190 CQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQ 231
Score = 89.0 bits (219), Expect = 1e-17
Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 16/202 (7%)
Query: 316 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT 375
+++ C EA+Q + E+AK + GF+ L NDQ+ LLK G E++ + N D
Sbjct: 309 IFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL 368
Query: 376 VFFEGKYGGMELFRAL--GCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGL 433
+ + E ++L + + F+F+ +AL + ++A++ A+++++ RPGL
Sbjct: 369 ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL 428
Query: 434 QEKRKVEQLQYNLELAFHHHLCKTHRQS--ILAKLPPK-GKLRSLCSQHVERLQIFQ--- 487
+ +E +Q NL A L H +S + AKL K LR + ++HV+ LQ+ +
Sbjct: 429 LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE 488
Query: 488 ---HLHPIVVQAAFPPLYKELF 506
LHP++ + +YK+L+
Sbjct: 489 TDMSLHPLLQE-----IYKDLY 505
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 117 bits (293), Expect = 3e-26
Identities = 51/102 (50%), Positives = 71/102 (69%), Gaps = 1/102 (0%)
Query: 23 TSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNR 82
++ + I C++CGDK+SG HYGV CEGCKGFFRR+ R Y NC I + SRN+
Sbjct: 103 SNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC-DLNCRIHKKSRNK 161
Query: 83 CQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQ 124
CQ+CR QKCLA+GMS +A++FGRM + +++ L AE+ + Q
Sbjct: 162 CQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQ 203
Score = 89.0 bits (219), Expect = 1e-17
Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 16/202 (7%)
Query: 316 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT 375
+++ C EA+Q + E+AK + GF+ L NDQ+ LLK G E++ + N D
Sbjct: 281 IFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL 340
Query: 376 VFFEGKYGGMELFRAL--GCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGL 433
+ + E ++L + + F+F+ +AL + ++A++ A+++++ RPGL
Sbjct: 341 ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL 400
Query: 434 QEKRKVEQLQYNLELAFHHHLCKTHRQS--ILAKLPPK-GKLRSLCSQHVERLQIFQ--- 487
+ +E +Q NL A L H +S + AKL K LR + ++HV+ LQ+ +
Sbjct: 401 LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE 460
Query: 488 ---HLHPIVVQAAFPPLYKELF 506
LHP++ + +YK+L+
Sbjct: 461 TDMSLHPLLQE-----IYKDLY 477
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 117 bits (293), Expect = 3e-26
Identities = 51/102 (50%), Positives = 71/102 (69%), Gaps = 1/102 (0%)
Query: 23 TSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNR 82
++ + I C++CGDK+SG HYGV CEGCKGFFRR+ R Y NC I + SRN+
Sbjct: 103 SNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC-DLNCRIHKKSRNK 161
Query: 83 CQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQ 124
CQ+CR QKCLA+GMS +A++FGRM + +++ L AE+ + Q
Sbjct: 162 CQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQ 203
Score = 89.0 bits (219), Expect = 1e-17
Identities = 56/202 (27%), Positives = 104/202 (51%), Gaps = 16/202 (7%)
Query: 316 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRT 375
+++ C EA+Q + E+AK + GF+ L NDQ+ LLK G E++ + N D
Sbjct: 281 IFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL 340
Query: 376 VFFEGKYGGMELFRAL--GCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGL 433
+ + E ++L + + F+F+ +AL + ++A++ A+++++ RPGL
Sbjct: 341 ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGL 400
Query: 434 QEKRKVEQLQYNLELAFHHHLCKTHRQS--ILAKLPPK-GKLRSLCSQHVERLQIFQ--- 487
+ +E +Q NL A L H +S + AKL K LR + ++HV+ LQ+ +
Sbjct: 401 LNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE 460
Query: 488 ---HLHPIVVQAAFPPLYKELF 506
LHP++ + +YK+L+
Sbjct: 461 TDMSLHPLLQE-----IYKDLY 477
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 116 bits (290), Expect = 6e-26
Identities = 51/86 (59%), Positives = 64/86 (74%)
Query: 25 QIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQ 84
Q + I C +CGDKSSG HYG TCEGCK FF+RS R N +Y+C +NCPID+ RN+CQ
Sbjct: 73 QQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQ 132
Query: 85 HCRLQKCLALGMSRDAVKFGRMSKKQ 110
+CRL+KCL +GM R+AV+ GRM Q
Sbjct: 133 YCRLKKCLKVGMRREAVQRGRMPPTQ 158
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 115 bits (288), Expect = 1e-25
Identities = 50/82 (60%), Positives = 61/82 (74%)
Query: 29 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRL 88
I C +CGDKSSG HYG TCEGCK FF+RS R N Y+C +NCPID+ RN+CQ+CRL
Sbjct: 84 IECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRL 143
Query: 89 QKCLALGMSRDAVKFGRMSKKQ 110
+KCL +GM R+AV+ GRM Q
Sbjct: 144 KKCLKVGMRREAVQRGRMPPTQ 165
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 115 bits (288), Expect = 1e-25
Identities = 49/81 (60%), Positives = 63/81 (77%)
Query: 30 PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQ 89
PC +C DKSSG HYGV +CEGCKGFFRRS + N Y+C R +NC I++ +RNRCQ+CRLQ
Sbjct: 78 PCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQ 137
Query: 90 KCLALGMSRDAVKFGRMSKKQ 110
KC +GMS++AV+ R KK+
Sbjct: 138 KCFEVGMSKEAVRNDRNKKKK 158
Score = 79.3 bits (194), Expect = 8e-15
Identities = 56/188 (29%), Positives = 91/188 (48%), Gaps = 21/188 (11%)
Query: 264 YASLTEIEHLVQSVCKSYRET----CQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWER 319
Y ++E L+ V K+++ET CQL ++ ++ + +W++
Sbjct: 169 YELSPQLEELITKVSKAHQETFPSLCQL----------GKYTTNSSADHRVQLDLGLWDK 218
Query: 320 CAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFE 379
+ T+ I +VEFAKRL GF L DQI LLKA ++++++R+C Y + T+ F
Sbjct: 219 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 278
Query: 380 GKYGGMELFRA----LGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQE 435
G+ L R G L +F F+ L L + E L +A+ LI R L+E
Sbjct: 279 ---DGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEE 335
Query: 436 KRKVEQLQ 443
KV++LQ
Sbjct: 336 PEKVDKLQ 343
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 115 bits (288), Expect = 1e-25
Identities = 49/81 (60%), Positives = 63/81 (77%)
Query: 30 PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQ 89
PC +C DKSSG HYGV +CEGCKGFFRRS + N Y+C R +NC I++ +RNRCQ+CRLQ
Sbjct: 89 PCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQ 148
Query: 90 KCLALGMSRDAVKFGRMSKKQ 110
KC +GMS++AV+ R KK+
Sbjct: 149 KCFEVGMSKEAVRNDRNKKKK 169
Score = 79.3 bits (194), Expect = 8e-15
Identities = 56/188 (29%), Positives = 91/188 (48%), Gaps = 21/188 (11%)
Query: 264 YASLTEIEHLVQSVCKSYRET----CQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWER 319
Y ++E L+ V K+++ET CQL ++ ++ + +W++
Sbjct: 180 YELSPQLEELITKVSKAHQETFPSLCQL----------GKYTTNSSADHRVQLDLGLWDK 229
Query: 320 CAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFE 379
+ T+ I +VEFAKRL GF L DQI LLKA ++++++R+C Y + T+ F
Sbjct: 230 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 289
Query: 380 GKYGGMELFRA----LGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQE 435
G+ L R G L +F F+ L L + E L +A+ LI R L+E
Sbjct: 290 ---DGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEE 346
Query: 436 KRKVEQLQ 443
KV++LQ
Sbjct: 347 PEKVDKLQ 354
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 114 bits (286), Expect = 2e-25
Identities = 54/109 (49%), Positives = 73/109 (66%), Gaps = 1/109 (0%)
Query: 6 QRQHRASRELLAAKKTHTSQIEVI-PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAA 64
+ Q +S EL+ + + V PC +C DKSSG HYGV CEGCKGFFRRS + N
Sbjct: 55 ETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMI 114
Query: 65 YSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDS 113
Y+C R +NC I++ +RNRCQ+CRLQKC +GMS+++V+ R KK+ S
Sbjct: 115 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETS 163
Score = 85.9 bits (211), Expect = 8e-17
Identities = 71/263 (26%), Positives = 126/263 (47%), Gaps = 29/263 (11%)
Query: 264 YASLTEIEHLVQSVCKSYRET----CQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWER 319
Y E++ L + + K+++ET CQL ++ ++ + +W++
Sbjct: 171 YEMTAELDDLTEKIRKAHQETFPSLCQL----------GKYTTNSSADHRVRLDLGLWDK 220
Query: 320 CAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFE 379
+ T+ I +VEFAKRL GF L DQI LLKA ++++++R+C Y + T+ F
Sbjct: 221 FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 280
Query: 380 GKYGGMELFRA----LGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQE 435
G+ L R G L +F F++ L L + E L +A+ LI R L+E
Sbjct: 281 ---DGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEE 337
Query: 436 KRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPK-GKLRSLCSQHVERLQIFQHLHPI 492
KV++LQ L A ++ K + + K+ K LRS+ ++ ER+ + +
Sbjct: 338 PTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLK----M 393
Query: 493 VVQAAFPPLYKELF-STETESPV 514
+ + PPL +E+ ++E P+
Sbjct: 394 EIPGSMPPLIQEMLENSEGHEPL 416
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 113 bits (282), Expect = 5e-25
Identities = 48/81 (59%), Positives = 62/81 (76%)
Query: 30 PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQ 89
PC +C DKSSG HYGV CEGCKGFFRRS + N Y+C R +NC I++ +RNRCQ+CRLQ
Sbjct: 87 PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQ 146
Query: 90 KCLALGMSRDAVKFGRMSKKQ 110
KC +GMS+++V+ R KK+
Sbjct: 147 KCFEVGMSKESVRNDRNKKKK 167
Score = 83.2 bits (204), Expect = 5e-16
Identities = 76/281 (27%), Positives = 131/281 (46%), Gaps = 35/281 (12%)
Query: 243 ELGQGPDSYGSPSFRSTPEAP-------YASLTEIEHLVQSVCKSYRET----CQLRLED 291
E+G +S + + E P Y E+ L++ V K+++ET CQL
Sbjct: 150 EVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLG--- 206
Query: 292 LLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIV 351
+ +N S + V+ ++W++ + T+ I VEFAK+L GF L DQI
Sbjct: 207 --KYTTNNSSEQRVS-----LDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259
Query: 352 LLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRA----LGCSELISSIFDFSHSL 407
LLKA ++++++R+C Y + T+ F G+ L R G L +F F++ L
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFS---DGLTLNRTQMHNAGFGPLTDLVFAFANQL 316
Query: 408 SALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAK 465
L + E L +A+ LI R L++ +V+ LQ L A ++ K R + K
Sbjct: 317 LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPK 376
Query: 466 LPPK-GKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKEL 505
+ K LRS+ ++ ER+ + + + + PPL +E+
Sbjct: 377 MLMKITDLRSISAKGAERVITLK----MEIPGSMPPLIQEM 413
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 113 bits (282), Expect = 5e-25
Identities = 48/81 (59%), Positives = 62/81 (76%)
Query: 30 PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQ 89
PC +C DKSSG HYGV CEGCKGFFRRS + N Y+C R +NC I++ +RNRCQ+CRLQ
Sbjct: 82 PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQ 141
Query: 90 KCLALGMSRDAVKFGRMSKKQ 110
KC +GMS+++V+ R KK+
Sbjct: 142 KCFEVGMSKESVRNDRNKKKK 162
Score = 83.2 bits (204), Expect = 5e-16
Identities = 76/281 (27%), Positives = 131/281 (46%), Gaps = 35/281 (12%)
Query: 243 ELGQGPDSYGSPSFRSTPEAP-------YASLTEIEHLVQSVCKSYRET----CQLRLED 291
E+G +S + + E P Y E+ L++ V K+++ET CQL
Sbjct: 145 EVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLG--- 201
Query: 292 LLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIV 351
+ +N S + V+ ++W++ + T+ I VEFAK+L GF L DQI
Sbjct: 202 --KYTTNNSSEQRVS-----LDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 254
Query: 352 LLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRA----LGCSELISSIFDFSHSL 407
LLKA ++++++R+C Y + T+ F G+ L R G L +F F++ L
Sbjct: 255 LLKAACLDILILRICTRYTPEQDTMTFS---DGLTLNRTQMHNAGFGPLTDLVFAFANQL 311
Query: 408 SALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAK 465
L + E L +A+ LI R L++ +V+ LQ L A ++ K R + K
Sbjct: 312 LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPK 371
Query: 466 LPPK-GKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKEL 505
+ K LRS+ ++ ER+ + + + + PPL +E+
Sbjct: 372 MLMKITDLRSISAKGAERVITLK----MEIPGSMPPLIQEM 408
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 113 bits (282), Expect = 5e-25
Identities = 48/81 (59%), Positives = 62/81 (76%)
Query: 30 PCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQ 89
PC +C DKSSG HYGV CEGCKGFFRRS + N Y+C R +NC I++ +RNRCQ+CRLQ
Sbjct: 87 PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQ 146
Query: 90 KCLALGMSRDAVKFGRMSKKQ 110
KC +GMS+++V+ R KK+
Sbjct: 147 KCFEVGMSKESVRNDRNKKKK 167
Score = 83.2 bits (204), Expect = 5e-16
Identities = 76/281 (27%), Positives = 131/281 (46%), Gaps = 35/281 (12%)
Query: 243 ELGQGPDSYGSPSFRSTPEAP-------YASLTEIEHLVQSVCKSYRET----CQLRLED 291
E+G +S + + E P Y E+ L++ V K+++ET CQL
Sbjct: 150 EVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLG--- 206
Query: 292 LLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIV 351
+ +N S + V+ ++W++ + T+ I VEFAK+L GF L DQI
Sbjct: 207 --KYTTNNSSEQRVS-----LDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259
Query: 352 LLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRA----LGCSELISSIFDFSHSL 407
LLKA ++++++R+C Y + T+ F G+ L R G L +F F++ L
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFS---DGLTLNRTQMHNAGFGPLTDLVFAFANQL 316
Query: 408 SALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAK 465
L + E L +A+ LI R L++ +V+ LQ L A ++ K R + K
Sbjct: 317 LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPK 376
Query: 466 LPPK-GKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKEL 505
+ K LRS+ ++ ER+ + + + + PPL +E+
Sbjct: 377 MLMKITDLRSISAKGAERVITLK----MEIPGSMPPLIQEM 413
>gi|36950991 nuclear receptor subfamily 2, group C, member 2 [Homo
sapiens]
Length = 615
Score = 112 bits (281), Expect = 6e-25
Identities = 126/500 (25%), Positives = 211/500 (42%), Gaps = 39/500 (7%)
Query: 20 KTHTSQIEVIP-CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRT 78
KT + +V+ C +CGDK+SG HYG ++CEGCKGFF+RS R N YSC Q+C I++
Sbjct: 124 KTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKH 183
Query: 79 SRNRCQHCRLQKCLALGMSRDAVKFGRMS---KKQRDSLHAEVQKQLQQRQQQQQEPVVK 135
RNRCQ CRL+KCL +GM ++V+ R ++++ S A +++ R + + P++
Sbjct: 184 HRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIR-KDLRSPLIA 242
Query: 136 TPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNL--AKA 193
TP A D T L G L P + E +L A+ S S A
Sbjct: 243 TPTFVAD-KDGARQTGLLDPGMLVNIQQPLIREDGT----VLLATDSKAETSQGALGTLA 297
Query: 194 GLNGASCHLEYSPERGKAEGRESFYSTGSQLTP--DRCGLRFEEHRHPGLGELGQGPDSY 251
+ + +L S G + + S++T D L G D+
Sbjct: 298 NVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTS 357
Query: 252 GSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNI-FSREEVTGYQR 310
G S + E+E + S T +L + + + N+ + E +
Sbjct: 358 GGGSIHVISRDQSTPIIEVEGPLLS---DTHVTFKLTMPSPMPEYLNVHYICESASRLLF 414
Query: 311 KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYN 370
SM W R A Q + + + + C N+ L A +V+ + A
Sbjct: 415 LSM--HWARS----IPAFQALGQDCN--TSLVRACWNELFTLGLAQCAQVMSLSTILAAI 466
Query: 371 ADN-RTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAH 429
++ + E K G + + + E I + +F +S++ L E A A+VL +
Sbjct: 467 VNHLQNSIQEDKLSGDRIKQVM---EHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPD 523
Query: 430 RPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS------ILAKLPPKGKLRSLCSQHVERL 483
PGL ++E+ Q ++ ++ KT+ + IL +LP LR + S E L
Sbjct: 524 HPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLP---ALRLMSSNITEEL 580
Query: 484 QIFQHLHPIVVQAAFPPLYK 503
+ + + + P + K
Sbjct: 581 FFTGLIGNVSIDSIIPYILK 600
>gi|189491739 nuclear receptor subfamily 2, group C, member 1
isoform a [Homo sapiens]
Length = 603
Score = 112 bits (281), Expect = 6e-25
Identities = 109/450 (24%), Positives = 195/450 (43%), Gaps = 44/450 (9%)
Query: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
C +CGDK+SG HYG +TCEGCKGFF+RS R N YSC ++C I++ RNRCQ+CRLQ+
Sbjct: 113 CVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHHRNRCQYCRLQR 172
Query: 91 CLALGMSRDAVKFGR----MSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADT 146
C+A GM +D+V+ R +S+++ + A +K ++ + P+ TP
Sbjct: 173 CIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRK--DLRSPLTATPTFVTDSES- 229
Query: 147 LTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAK-AGLNGASCHLEYS 205
T + GL D + + P + + +L S S +L+ A + + +L +
Sbjct: 230 -TRSTGLLDSGMFMNIHPSGVKTES---AVLMTSDKAESCQGDLSTLANVVTSLANLGKT 285
Query: 206 PERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYG---SPSFRSTPEA 262
+ + S + S C F+E + G++ + D+ +P + ++
Sbjct: 286 KDLSQNSNEMSMIESLSNDDTSLC--EFQEMQTN--GDVSRAFDTLAKALNPGESTACQS 341
Query: 263 PYASLTEIEHLVQSVCK-SYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA 321
A + HL+ +Y E E L S++ R + + +
Sbjct: 342 SVAGMEGSVHLITGDSSINYTEK-----EGPLLSDSHVAFRLTMPSPMPEYL------NV 390
Query: 322 HHLTEAIQYV----VEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF 377
H++ E+ + + +A + F L Q + I L+KA E+ + + + + N
Sbjct: 391 HYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATI 450
Query: 378 FEG---------KYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINA 428
+ M R E I + +F +S+ L E A A+VL +
Sbjct: 451 LATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFCNSMVKLCIDGYEYAYLKAIVLFSP 510
Query: 429 HRPGLQEKRKVEQLQYNLELAFHHHLCKTH 458
P L+ ++E+ Q + F ++ KT+
Sbjct: 511 DHPSLENMEQIEKFQEKAYVEFQDYITKTY 540
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 111 bits (278), Expect = 1e-24
Identities = 59/146 (40%), Positives = 80/146 (54%), Gaps = 14/146 (9%)
Query: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
C ICGD+SSG HYGV +CEGCKGFF+R+ R + YSC ++C +D+ RNRCQ+CR QK
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQK 264
Query: 91 CLALGMSRDAVKFGRMSKKQRD----SLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADT 146
CLA GM R+AV+ R K +D ++ R + + V + G +G
Sbjct: 265 CLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEG--- 321
Query: 147 LTYTLGLPDGQLPLGSSPDLPEASAC 172
P G GSSP+ P + C
Sbjct: 322 -------PGGTGGSGSSPNDPVTNIC 340
Score = 40.8 bits (94), Expect = 0.003
Identities = 36/161 (22%), Positives = 70/161 (43%), Gaps = 14/161 (8%)
Query: 331 VVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRA 390
+VE+AKR+ F L +DQ++LL+AG E+++ + D R G+ + R
Sbjct: 350 LVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHR-SIDVRDGILLAT--GLHVHRN 406
Query: 391 LGCSELISSIFD-----FSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYN 445
S + +IFD + + + E+ A++L N GL +VE L+
Sbjct: 407 SAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREK 466
Query: 446 LELAFHHHLCKTHRQ------SILAKLPPKGKLRSLCSQHV 480
+ + + + + + +L +LP + C +H+
Sbjct: 467 VYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHL 507
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 111 bits (277), Expect = 2e-24
Identities = 49/91 (53%), Positives = 66/91 (72%), Gaps = 3/91 (3%)
Query: 29 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAY-SCTRQQNCPIDRTSRNRCQHCR 87
I C+ICGDK+SG HYGV CEGCKGFFRR+ R Y C R +C I + +RN+CQ+CR
Sbjct: 100 IECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDR--SCKIQKKNRNKCQYCR 157
Query: 88 LQKCLALGMSRDAVKFGRMSKKQRDSLHAEV 118
KCL++GMS +A++FGRM + ++ L AE+
Sbjct: 158 FHKCLSVGMSHNAIRFGRMPRSEKAKLKAEI 188
Score = 80.9 bits (198), Expect = 3e-15
Identities = 57/224 (25%), Positives = 96/224 (42%), Gaps = 9/224 (4%)
Query: 289 LEDLLRQRSNIFSREEVTGYQRKSMW-EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQN 347
+E L + ++ G Q K ++ C E + + EFAK + GF L N
Sbjct: 244 METLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLN 303
Query: 348 DQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALG--CSELISSIFDFSH 405
DQ+ LLK G E + + N D V + + E ++L +++ FDF+
Sbjct: 304 DQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAM 363
Query: 406 SLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA- 464
+AL + +I+L+ A ++ RPGL +E++Q + HL H I
Sbjct: 364 KFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLF 423
Query: 465 --KLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELF 506
L LR L ++H + +QI + AA PL +E++
Sbjct: 424 PKLLQKMADLRQLVTEHAQLVQIIKKTES---DAALHPLLQEIY 464
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 111 bits (277), Expect = 2e-24
Identities = 49/91 (53%), Positives = 66/91 (72%), Gaps = 3/91 (3%)
Query: 29 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAY-SCTRQQNCPIDRTSRNRCQHCR 87
I C+ICGDK+SG HYGV CEGCKGFFRR+ R Y C R +C I + +RN+CQ+CR
Sbjct: 100 IECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDR--SCKIQKKNRNKCQYCR 157
Query: 88 LQKCLALGMSRDAVKFGRMSKKQRDSLHAEV 118
KCL++GMS +A++FGRM + ++ L AE+
Sbjct: 158 FHKCLSVGMSHNAIRFGRMPRSEKAKLKAEI 188
Score = 80.9 bits (198), Expect = 3e-15
Identities = 57/224 (25%), Positives = 96/224 (42%), Gaps = 9/224 (4%)
Query: 289 LEDLLRQRSNIFSREEVTGYQRKSMW-EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQN 347
+E L + ++ G Q K ++ C E + + EFAK + GF L N
Sbjct: 244 METLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLN 303
Query: 348 DQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALG--CSELISSIFDFSH 405
DQ+ LLK G E + + N D V + + E ++L +++ FDF+
Sbjct: 304 DQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAM 363
Query: 406 SLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA- 464
+AL + +I+L+ A ++ RPGL +E++Q + HL H I
Sbjct: 364 KFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLF 423
Query: 465 --KLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELF 506
L LR L ++H + +QI + AA PL +E++
Sbjct: 424 PKLLQKMADLRQLVTEHAQLVQIIKKTES---DAALHPLLQEIY 464
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 110 bits (276), Expect = 2e-24
Identities = 59/143 (41%), Positives = 83/143 (58%), Gaps = 9/143 (6%)
Query: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
C ICGD+SSG HYGV +CEGCKGFF+R+ R + Y+C ++C ID+ RNRCQ+CR QK
Sbjct: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQK 194
Query: 91 CLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADT-LTY 149
CLA+GM R+AV+ R K R+ EV+ + E +++ A +T +
Sbjct: 195 CLAMGMKREAVQEERQRGKDRN--ENEVESTSSANEDMPVERILEAELAVEPKTETYVEA 252
Query: 150 TLGLPDGQLPLGSSPDLPEASAC 172
+GL SSP+ P + C
Sbjct: 253 NMGLNP------SSPNDPVTNIC 269
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 18/163 (11%)
Query: 331 VVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRA 390
+VE+AKR+ F EL +DQ++LL+AG E+++ A + G+ + R
Sbjct: 279 LVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLA---TGLHVHRN 335
Query: 391 LGCSELISSIFD-----FSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYN 445
S + +IFD + + + E+ A+VL N GL +VE L+
Sbjct: 336 SAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK 395
Query: 446 LELAFHHHLCKTHR--------QSILAKLPPKGKLRSLCSQHV 480
+ + + CK H+ +L +LP + C +H+
Sbjct: 396 VYASLEAY-CK-HKYPEQPGRFAKLLLRLPALRSIGLKCLEHL 436
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 109 bits (273), Expect = 5e-24
Identities = 50/108 (46%), Positives = 71/108 (65%), Gaps = 4/108 (3%)
Query: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
C +CGD ++ HYGV TCEGCKGFF+R+ + NA Y C +NCP+D+ RNRCQ+CR QK
Sbjct: 303 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQK 362
Query: 91 CLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPP 138
CL++GM ++ V+ + K +R L ++ + LQQ Q P +PP
Sbjct: 363 CLSVGMVKEVVRTDSL-KGRRGRLPSKPKSPLQQEPSQPSPP---SPP 406
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/167 (27%), Positives = 88/167 (52%), Gaps = 13/167 (7%)
Query: 324 LTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM-CRAYNADNRTVFFEG-K 381
LT +I +A+++ GF +L + DQ +L+++ +E+ ++R+ R+ A+++ VF G
Sbjct: 452 LTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLV 511
Query: 382 YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ 441
++ R G E + SI DFS +L +L+ +A +AL +I R GL+E ++VE+
Sbjct: 512 LHRLQCLRGFG--EWLDSIKDFSLNLQSLNLDIQALACLSALSMI-TERHGLKEPKRVEE 568
Query: 442 LQYNLELAFHHHLCKTH-----RQSILAKLPPKGKLRSLCSQHVERL 483
L + + H K +L L +LR +C+ ++R+
Sbjct: 569 LCNKITSSLKDHQSKGQALEPTESKVLGALV---ELRKICTLGLQRI 612
>gi|27894359 nuclear receptor subfamily 4, group A, member 3 isoform
c [Homo sapiens]
Length = 443
Score = 109 bits (273), Expect = 5e-24
Identities = 50/108 (46%), Positives = 71/108 (65%), Gaps = 4/108 (3%)
Query: 31 CKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQK 90
C +CGD ++ HYGV TCEGCKGFF+R+ + NA Y C +NCP+D+ RNRCQ+CR QK
Sbjct: 292 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQK 351
Query: 91 CLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPP 138
CL++GM ++ V+ + K +R L ++ + LQQ Q P +PP
Sbjct: 352 CLSVGMVKEVVRTDSL-KGRRGRLPSKPKSPLQQEPSQPSPP---SPP 395
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,856,170
Number of Sequences: 37866
Number of extensions: 1067345
Number of successful extensions: 6062
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 4984
Number of HSP's gapped (non-prelim): 816
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.