Search of human proteins with 19718764

Search of human proteins with 19718764

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo
sapiens]
         (872 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]    1749   0.0  
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]    1736   0.0  
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]    1710   0.0  
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        346   5e-95
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            301   1e-81
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            298   1e-80
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       279   9e-75
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     230   4e-60
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      226   7e-59
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   213   8e-55
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   213   8e-55
gi|222352183 neural precursor cell expressed, developmentally do...   204   3e-52
gi|21361472 neural precursor cell expressed, developmentally dow...   204   3e-52
gi|222352094 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352092 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352090 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352088 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352086 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352084 neural precursor cell expressed, developmentally do...   204   3e-52
gi|222352082 neural precursor cell expressed, developmentally do...   204   3e-52
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      204   4e-52
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   201   2e-51
gi|114520609 neural precursor cell expressed, developmentally do...   201   2e-51
gi|114520607 neural precursor cell expressed, developmentally do...   201   2e-51
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   201   2e-51
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   197   3e-50
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   197   3e-50
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              197   4e-50
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   193   7e-49
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   192   1e-48

>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score = 1749 bits (4530), Expect = 0.0
 Identities = 872/872 (100%), Positives = 872/872 (100%)

Query: 1   MATACKRSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRM 60
           MATACKRSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRM
Sbjct: 1   MATACKRSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRM 60

Query: 61  DNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFK 120
           DNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFK
Sbjct: 61  DNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFK 120

Query: 121 DVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA 180
           DVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA
Sbjct: 121 DVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQA 180

Query: 181 KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVY 240
           KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVY
Sbjct: 181 KDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVY 240

Query: 241 TRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLE 300
           TRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLE
Sbjct: 241 TRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLE 300

Query: 301 MALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVN 360
           MALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVN
Sbjct: 301 MALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVN 360

Query: 361 DDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGP 420
           DDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGP
Sbjct: 361 DDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGP 420

Query: 421 RVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFI 480
           RVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFI
Sbjct: 421 RVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFI 480

Query: 481 LNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMI 540
           LNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMI
Sbjct: 481 LNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMI 540

Query: 541 AMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNP 600
           AMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNP
Sbjct: 541 AMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNP 600

Query: 601 SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLK 660
           SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLK
Sbjct: 601 SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLK 660

Query: 661 DLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILN 720
           DLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILN
Sbjct: 661 DLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILN 720

Query: 721 KSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRD 780
           KSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRD
Sbjct: 721 KSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRD 780

Query: 781 SVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTC 840
           SVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTC
Sbjct: 781 SVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTC 840

Query: 841 FNVLLLPEYSSKEKLKERLLKAITYAKGFGML 872
           FNVLLLPEYSSKEKLKERLLKAITYAKGFGML
Sbjct: 841 FNVLLLPEYSSKEKLKERLLKAITYAKGFGML 872


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score = 1736 bits (4495), Expect = 0.0
 Identities = 865/866 (99%), Positives = 866/866 (100%)

Query: 7   RSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA 66
           +SGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA
Sbjct: 10  KSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAA 69

Query: 67  IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT 126
           IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT
Sbjct: 70  IKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLT 129

Query: 127 EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD 186
           EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD
Sbjct: 130 EEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKD 189

Query: 187 EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN 246
           EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN
Sbjct: 190 EDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSN 249

Query: 247 EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF 306
           EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF
Sbjct: 250 EKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLF 309

Query: 307 CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV 366
           CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV
Sbjct: 310 CKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIV 369

Query: 367 AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE 426
           AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE
Sbjct: 370 AASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLE 429

Query: 427 TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK 486
           TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK
Sbjct: 430 TELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTK 489

Query: 487 NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA 546
           NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA
Sbjct: 490 NLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA 549

Query: 547 DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE 606
           DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE
Sbjct: 550 DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETE 609

Query: 607 GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE 666
           GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE
Sbjct: 610 GQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE 669

Query: 667 GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ 726
           GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ
Sbjct: 670 GNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQ 729

Query: 727 FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE 786
           FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE
Sbjct: 730 FKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIRE 789

Query: 787 FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL 846
           FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL
Sbjct: 790 FWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLL 849

Query: 847 PEYSSKEKLKERLLKAITYAKGFGML 872
           PEYSSKEKLKERLLKAITYAKGFGML
Sbjct: 850 PEYSSKEKLKERLLKAITYAKGFGML 875


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score = 1710 bits (4428), Expect = 0.0
 Identities = 852/852 (100%), Positives = 852/852 (100%)

Query: 21  MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 80
           MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC
Sbjct: 1   MKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLC 60

Query: 81  DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 140
           DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER
Sbjct: 61  DPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCRER 120

Query: 141 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 200
           EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM
Sbjct: 121 EDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAM 180

Query: 201 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 260
           EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL
Sbjct: 181 EEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYL 240

Query: 261 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 320
           SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK
Sbjct: 241 SPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGK 300

Query: 321 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 380
           LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV
Sbjct: 301 LIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANV 360

Query: 381 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 440
           VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL
Sbjct: 361 VGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPL 420

Query: 441 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 500
           IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS
Sbjct: 421 IPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYS 480

Query: 501 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 560
           ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ
Sbjct: 481 ERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQ 540

Query: 561 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 620
           GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI
Sbjct: 541 GVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAI 600

Query: 621 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 680
           YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS
Sbjct: 601 YNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQIS 660

Query: 681 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 740
           QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE
Sbjct: 661 QTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNE 720

Query: 741 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 800
           SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR
Sbjct: 721 SPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKR 780

Query: 801 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 860
           LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
Sbjct: 781 LFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL 840

Query: 861 KAITYAKGFGML 872
           KAITYAKGFGML
Sbjct: 841 KAITYAKGFGML 852


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  346 bits (888), Expect = 5e-95
 Identities = 184/450 (40%), Positives = 277/450 (61%), Gaps = 24/450 (5%)

Query: 439 PLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRM 498
           PLIP+ +F N  L+ +  M++ +T+      ++FSF   PF+++   K + +  D+  +M
Sbjct: 333 PLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQM 392

Query: 499 YSERRITVLYSLVQGQQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVE 555
            +  R +++  + + Q+ +    +L +KVRR H++ D+L  L        ADLKK+L V 
Sbjct: 393 INIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELT----RKRADLKKKLKVT 448

Query: 556 FEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIV 615
           F GE G+D GG++KE+F L++ +IF+PD GMFTY + +   WF+    +   +F L+GI+
Sbjct: 449 FVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGIL 508

Query: 616 LGLAIYNNCILDVHFPMVVYRKLMGK--------------KGTFRDLGDSHPVLYQSLKD 661
           +GLA+YN+  LD+ FP   Y+KL+                  T  DL    P L   L +
Sbjct: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568

Query: 662 LLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNK 721
           LL +EGNVE+D   TFQ+ Q + FG    Y+LK  GDKI +TN+NRKE+V LY+D++LNK
Sbjct: 569 LLSHEGNVEEDFYSTFQVFQEE-FGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNK 627

Query: 722 SVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDS 781
           S+ KQF AF  GFH V   + L  L RPEE+E+L+CGS +LD  AL+ +T+YD GY +  
Sbjct: 628 SIYKQFAAFYYGFHSVCASNAL-MLLRPEEVEILVCGSPDLDMHALQRSTQYD-GYAKTD 685

Query: 782 VLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCF 841
           + I+ FW++V  F  + ++  L FTTG+DR PVGG+  L   I+KN   T  LP +HTCF
Sbjct: 686 LTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCF 745

Query: 842 NVLLLPEYSSKEKLKERLLKAITYAKGFGM 871
           N L LP Y SK+ LK++L+  I+ ++GFG+
Sbjct: 746 NQLCLPPYKSKKDLKQKLIIGISNSEGFGL 775


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  301 bits (772), Expect = 1e-81
 Identities = 168/445 (37%), Positives = 260/445 (58%), Gaps = 17/445 (3%)

Query: 440  LIPFEEFINEPLNEVLEMDKDYT------FFKVETENKFSFMTCPFILNAVTKNLGLYYD 493
            +I +++F    + E++++  DY        + +  +   +  T PF+ +A  K   L  D
Sbjct: 610  IIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLADIPVTICTYPFVFDAQAKTTLLQTD 669

Query: 494  NRIRMY-----SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 548
              ++M      + R+      L   + +NP L L VRR++I+ DA+   E++      D 
Sbjct: 670  AVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDY 726

Query: 549  KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQ 608
            KK L V F GE  VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    
Sbjct: 727  KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDL 786

Query: 609  FTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EG 667
            F LIG++ GLAIYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E 
Sbjct: 787  FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPED 846

Query: 668  NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQF 727
            ++E+   + F I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F
Sbjct: 847  DIEETFCLNFTIT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLF 905

Query: 728  KAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREF 787
             AF  GFH V     L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ F
Sbjct: 906  DAFHAGFHKVCGGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIF 964

Query: 788  WEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLP 847
            WE+ H    E+K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP
Sbjct: 965  WEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLP 1024

Query: 848  EYSSKEKLKERLLKAITYAKGFGML 872
            +Y+ KE L+ +L++AI + +GF ++
Sbjct: 1025 KYTEKETLRSKLIQAIDHNEGFSLI 1049


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  298 bits (763), Expect = 1e-80
 Identities = 167/434 (38%), Positives = 255/434 (58%), Gaps = 12/434 (2%)

Query: 445  EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMY----- 499
            ++IN    +   MD ++   ++  +   +  T PF+ +A  K   L  D  ++M      
Sbjct: 630  DYINWVQQQAYGMDVNHGLTEL-ADIPVTICTYPFVFDAQAKTTLLQTDAVLQMQMAIDQ 688

Query: 500  SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGE 559
            + R+      L   + +NP L L VRR++I+ DA+   E++      D KK L V F GE
Sbjct: 689  AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAM---EVLRKTKNIDYKKPLKVIFVGE 745

Query: 560  QGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLA 619
              VD GGV KEFF L++ E+ +P  GMF Y E ++L WF+  +FE    F LIG++ GLA
Sbjct: 746  DAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICGLA 805

Query: 620  IYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDDMMITFQ 678
            IYN  I+D+HFP+ +Y+KL+ KK +  DL +  P + +S++ LL+Y E ++E+   + F 
Sbjct: 806  IYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFT 865

Query: 679  ISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVT 738
            I+  + FG   + +L  NG    +  +NR+EFV+ Y DYI NKSV   F AF  GFH V 
Sbjct: 866  IT-VENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVC 924

Query: 739  NESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQ 798
                L  LF+P E++ ++ G+ N D++ LE+ TEY G Y  +   I+ FWE+ H    E+
Sbjct: 925  GGKVL-LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEK 983

Query: 799  KRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
            K+ FL F TG+DR P+ G+  LK++I   G   E LP SHTCFN+L LP+Y+ KE L+ +
Sbjct: 984  KKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSK 1043

Query: 859  LLKAITYAKGFGML 872
            L++AI + +GF ++
Sbjct: 1044 LIQAIDHNEGFSLI 1057


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  279 bits (713), Expect = 9e-75
 Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)

Query: 441  IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 490
            + ++ F    ++ ++++ +DY  + +            ++  +  + PFI +A  K   L
Sbjct: 607  VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666

Query: 491  YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 544
              D  ++M       + + + +L +L      +P+L L VRR++++ DAL  L   ++ +
Sbjct: 667  QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723

Query: 545  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 604
              DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP  GMFTY + + L WF+ + F 
Sbjct: 724  DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783

Query: 605  TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 664
                F LIGI  GLAIYN+ ++D+HFP+ +Y+KL+  K    DL +  P   +SL++LL+
Sbjct: 784  EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843

Query: 665  YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 723
            Y G +VE+   + F I + + +G      L   GD + +  +NR+EFV+ Y +Y+   SV
Sbjct: 844  YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902

Query: 724  EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 783
             + + AF  GF  V     L+ LF+P E+  ++ G+ N +++ LEET  Y G Y+     
Sbjct: 903  HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961

Query: 784  IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 843
            ++ FWE  H F  E+K+ FL F TG+DR P+ G+  L+++I       E LP +HTC+N+
Sbjct: 962  VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021

Query: 844  LLLPEYSSKEKLKERLLKAITYAKGFGM 871
            L LP+YSSKE L  RL +A+   +GF +
Sbjct: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  230 bits (587), Expect = 4e-60
 Identities = 148/458 (32%), Positives = 245/458 (53%), Gaps = 31/458 (6%)

Query: 431  VKTLDCRKP--LIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTC------PFILN 482
            V  + C+ P  +   +E ++  LN  +E+ + Y  +K+  +   +   C      PFI N
Sbjct: 580  VNQVKCQLPESIFQVDELLHR-LNFFVEVCRRY-LWKMTVDASENVQCCVIFSHFPFIFN 637

Query: 483  AVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQ------LNPYLRLKVRRDHIIDDALVR 536
             ++K   L+ D  +++ S++    L S    ++      L P   L VRR+H+I+D L +
Sbjct: 638  NLSKIKLLHTDTLLKIESKKHKAYLRSAAIEEERESEFALRPTFDLTVRRNHLIEDVLNQ 697

Query: 537  LEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLF 596
            L     E   DL+K+L+V F GE G D GGV KEFF  +  E+  P+ GMF Y E     
Sbjct: 698  LSQFENE---DLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCM 754

Query: 597  WFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 656
            WF       + ++   G++ GL+++N  + ++ FP+ +++KL+ +  +  DL +  P L 
Sbjct: 755  WFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLG 814

Query: 657  QSLKDLLEYEG-NVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNL 713
            ++L+ LL+ EG N E+   I F +   + D        +L  NG  I +   N++++V+ 
Sbjct: 815  KNLQTLLDDEGDNFEEVFYIHFNVHWDRNDT-------NLIPNGSSITVNQTNKRDYVSK 867

Query: 714  YSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 773
            Y +YI N SV+  ++ FRRGF+ + +E  +K LF PEE++ +I G+ + D++  E+   Y
Sbjct: 868  YINYIFNDSVKAVYEEFRRGFYKMCDEDIIK-LFHPEELKDVIVGNTDYDWKTFEKNARY 926

Query: 774  DGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER 833
            + GY      I  FW+  H  T E+K+ FL F TGTDR  +  L  +K+         ER
Sbjct: 927  EPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWNER 986

Query: 834  LP-TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFG 870
             P  + TCF+VL LP+YS+ E ++E L +AI   +GFG
Sbjct: 987  DPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  226 bits (576), Expect = 7e-59
 Identities = 147/454 (32%), Positives = 246/454 (54%), Gaps = 26/454 (5%)

Query: 431  VKTLDCRKPLIPFE-----EFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVT 485
            V   +CR P   F        +N  ++   ++ +D      ET +   F   PFI N+++
Sbjct: 572  VNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFPFIFNSLS 631

Query: 486  KNLGLYYDNRIRMY-SERRITVLY--SLVQGQQL---NPYLRLKVRRDHIIDDALVRLEM 539
            K   L  D+ I+M  SE++  +L   +++Q +     +P   L+VRR  ++ DAL +L  
Sbjct: 632  KIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQL-- 689

Query: 540  IAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFN 599
             +     D  K L VEF  E   + GGVS EFF  + EE+  P+ GMF Y E     WF 
Sbjct: 690  -SQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFP 748

Query: 600  PSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL 659
                  + ++ L G++ GL+++N  + ++ FP+ +Y+KL+ +K +  DL +  P L +SL
Sbjct: 749  AKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSL 808

Query: 660  KDLL-EYEGNVEDDMMITFQI--SQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSD 716
            +++L +   ++ D + I F I   Q D+       DL  NG  IP+   N++++V+ Y D
Sbjct: 809  QEVLDDAADDIGDALCIRFSIHWDQNDV-------DLIPNGISIPVDQTNKRDYVSKYID 861

Query: 717  YILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGG 776
            YI N SV+  ++ F+RGF+ V  +  L++ F PEE+   I G+ + D++  E+ ++Y+ G
Sbjct: 862  YIFNVSVKAVYEEFQRGFYRVCEKEILRH-FYPEELMTAIIGNTDYDWKQFEQNSKYEQG 920

Query: 777  YTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTER-LP 835
            Y +    I+ FW+  H  T ++K+ FL F TG DR    G+ K++++       +ER  P
Sbjct: 921  YQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHP 980

Query: 836  TSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 869
            TS TC N+L LP+YS+ E+++E L  AI   +GF
Sbjct: 981  TSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  213 bits (541), Expect = 8e-55
 Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)

Query: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
           L     L  ++++ V R  + +D+    + I    P DL+++LY+   GE+G+D GG+++
Sbjct: 66  LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 122

Query: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 625
           E+F L+  E+ NP   +F Y  ++      NP+S       T    IG  + +A+Y+   
Sbjct: 123 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 182

Query: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
           +D  F +  Y++++ K+ T +DL    P  Y S+  + E   N+E+  +  + I   ++ 
Sbjct: 183 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 240

Query: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
           G    ++LKE G+ I +T EN++E++ L +D+   + VE+Q KAF  GF+ V     L+Y
Sbjct: 241 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 300

Query: 746 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 805
            F  +E+EL++CG + +D    +++T Y   YT++S  I+ FW++V    +E++   LQF
Sbjct: 301 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 358

Query: 806 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
            TGT R PVGG  +L       K  I K G +T  LP SHTCFN L LP Y S E+L+E+
Sbjct: 359 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 417

Query: 859 LLKAITYAKGFG 870
           LL AI   +GFG
Sbjct: 418 LLYAIEETEGFG 429


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
           isoform 1 [Homo sapiens]
          Length = 870

 Score =  213 bits (541), Expect = 8e-55
 Identities = 127/372 (34%), Positives = 208/372 (55%), Gaps = 19/372 (5%)

Query: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
           L     L  ++++ V R  + +D+    + I    P DL+++LY+   GE+G+D GG+++
Sbjct: 505 LCHSNALPSHVKISVSRQTLFEDSF---QQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAR 561

Query: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQFT---LIGIVLGLAIYNNCI 625
           E+F L+  E+ NP   +F Y  ++      NP+S       T    IG  + +A+Y+   
Sbjct: 562 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKF 621

Query: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
           +D  F +  Y++++ K+ T +DL    P  Y S+  + E   N+E+  +  + I   ++ 
Sbjct: 622 IDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKE--NNLEECGLELYFIQDMEIL 679

Query: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
           G    ++LKE G+ I +T EN++E++ L +D+   + VE+Q KAF  GF+ V     L+Y
Sbjct: 680 GKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRY 739

Query: 746 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 805
            F  +E+EL++CG + +D    +++T Y   YT++S  I+ FW++V    +E++   LQF
Sbjct: 740 -FDEKELELMLCGMQEIDMSDWQKSTIY-RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQF 797

Query: 806 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
            TGT R PVGG  +L       K  I K G +T  LP SHTCFN L LP Y S E+L+E+
Sbjct: 798 VTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYEQLREK 856

Query: 859 LLKAITYAKGFG 870
           LL AI   +GFG
Sbjct: 857 LLYAIEETEGFG 868


>gi|222352183 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 868 GF 869
           GF
Sbjct: 849 GF 850


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 600 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 657

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 658 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 717

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 718 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 773

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 774 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 832

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 833 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 892

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 893 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 949

Query: 868 GF 869
           GF
Sbjct: 950 GF 951


>gi|222352094 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828

Query: 868 GF 869
           GF
Sbjct: 829 GF 830


>gi|222352092 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 479 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 536

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 537 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 596

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 597 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 652

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 653 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 711

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 712 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 771

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 772 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 828

Query: 868 GF 869
           GF
Sbjct: 829 GF 830


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 592 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 649

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 650 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 709

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 710 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 765

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 766 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 824

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 825 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 884

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 885 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 941

Query: 868 GF 869
           GF
Sbjct: 942 GF 943


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 612 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 669

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 670 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 729

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 730 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 785

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 786 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 844

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 845 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 904

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 905 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 961

Query: 868 GF 869
           GF
Sbjct: 962 GF 963


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 620 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 677

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 678 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 737

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 738 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 793

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 794 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 852

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 853 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 912

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 913 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 969

Query: 868 GF 869
           GF
Sbjct: 970 GF 971


>gi|222352084 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 868 GF 869
           GF
Sbjct: 849 GF 850


>gi|222352082 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/362 (35%), Positives = 202/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+ R++I +++  R+  ++++ P  LK +L++EFE E+G+D GGV++E+F L+ +E+FN
Sbjct: 499 MKLHRNNIFEESYRRI--MSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFN 556

Query: 582 PDIGMFTYDESTK-LFWFNPSS----FETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    FT IG V GLA+++  +LD  F    Y+
Sbjct: 557 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYK 616

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++GK+ T  D+       Y SLK +LE   N   ++ + F I + + FG     DLK N
Sbjct: 617 MMLGKQITLNDMESVDSEYYNSLKWILE---NDPTELDLMFCIDEEN-FGQTYQVDLKPN 672

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TNEN++E+++L   +     V+KQ  AF  GF  +     +K +F   E+ELL+
Sbjct: 673 GSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK-IFDENELELLM 731

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     + + Y  GY  +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 732 CGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNG 791

Query: 817 LGKLKMIIAKNGP---------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP           E+LP +HTCFN L LP Y + E L+E+LL A+  A+
Sbjct: 792 FAEL---YGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ 848

Query: 868 GF 869
           GF
Sbjct: 849 GF 850


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  204 bits (518), Expect = 4e-52
 Identities = 124/365 (33%), Positives = 199/365 (54%), Gaps = 21/365 (5%)

Query: 520  LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 579
            + + VRRDH+ +D+   L     ++P ++K +LY+ FEGE+G D GG+ +E++ ++  E+
Sbjct: 4017 MAVHVRRDHVFEDSYRELHR---KSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREM 4073

Query: 580  FNPDIGMFTYDESTKL-FWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 635
            FNP   +F      ++ +  NPSS         F  +G ++  A+Y+N +L+ +F    Y
Sbjct: 4074 FNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFY 4133

Query: 636  RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYE-GNVEDDMMITFQISQTDLFGNPMMYDLK 694
            + ++GK   + D+       YQ L  LLE +   +  D+  + ++ +   FG   + DLK
Sbjct: 4134 KHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQE---FGVCEVRDLK 4190

Query: 695  ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
             NG  I +T EN+KE+V+L     +  ++ KQ  AF  GF+ +  +  L  +F  +E+EL
Sbjct: 4191 PNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKR-LISIFTEQELEL 4249

Query: 755  LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
            LI G   +D   L+  TEY   Y  +S+ I+ FW  + SF    +  FLQF TGT + P+
Sbjct: 4250 LISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4308

Query: 815  GGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI-TYA 866
             G   L       K  I ++   T+RLP++HTCFN L LP Y S EKL+  LL AI   +
Sbjct: 4309 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECS 4368

Query: 867  KGFGM 871
            +GFG+
Sbjct: 4369 EGFGL 4373



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 16/50 (32%), Positives = 24/50 (48%)

Query: 168  KQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQG 217
            ++HT+EE  S   +DED  +DE+E+        +ED E       D   G
Sbjct: 2413 EEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDG 2462


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
           [Homo sapiens]
          Length = 922

 Score =  201 bits (512), Expect = 2e-51
 Identities = 127/372 (34%), Positives = 202/372 (54%), Gaps = 19/372 (5%)

Query: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
           L Q   L  ++++ V R  + +D+    + I    P DL+++LYV F GE+G+D GG+++
Sbjct: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613

Query: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 625
           E+F L+  E+ NP   +F Y  ++      NP+S    +    F  IG  + +A+++   
Sbjct: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673

Query: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
           +D  F +  Y++++ KK T +DL       Y SL  +   + N+E+  +  +     ++ 
Sbjct: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731

Query: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
           G    +DLK  G  I +T EN+ E++ L +++  ++ V++Q KAF  GF+ V     L+Y
Sbjct: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQY 791

Query: 746 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 805
            F  +E+E+++CG + +D    +  T Y   YTR+S  I  FW+ V    +E +   LQF
Sbjct: 792 -FDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLLQF 849

Query: 806 TTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
            TGT R P+GG  +L       K  I K G DT  LP SHTCFN L LP Y S E+LKE+
Sbjct: 850 VTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEK 908

Query: 859 LLKAITYAKGFG 870
           LL AI   +GFG
Sbjct: 909 LLFAIEETEGFG 920


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  201 bits (512), Expect = 2e-51
 Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           +K+RR  +++D+  R+  + ++    LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 545 MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 602

Query: 582 PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
           P  G+F Y  +       NP+S     +    F  IG V G+A+Y+  +LD  F    Y+
Sbjct: 603 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 662

Query: 637 KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
            ++ K  T  D+       Y SL+ +LE   N   ++ + F I + +LFG    ++LK  
Sbjct: 663 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 718

Query: 697 GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
           G +I +TN+N+KE++ L   +     ++KQ  AF+ GF  +  +  +K +F   E+ELL+
Sbjct: 719 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 777

Query: 757 CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
           CG  ++D     E T+Y  GY+ +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 778 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 837

Query: 817 LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
             +L      NGP +         E+LP +HTCFN L LP Y S E+L ++L  AI   +
Sbjct: 838 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894

Query: 868 GF 869
           GF
Sbjct: 895 GF 896


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  201 bits (512), Expect = 2e-51
 Identities = 123/362 (33%), Positives = 201/362 (55%), Gaps = 24/362 (6%)

Query: 522  LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
            +K+RR  +++D+  R+  + ++    LK +L++EF+GE+G+D GGV++E+F L+ +E+FN
Sbjct: 892  MKLRRATVLEDSYRRI--MGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN 949

Query: 582  PDIGMFTYDESTKL-FWFNPSSF----ETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR 636
            P  G+F Y  +       NP+S     +    F  IG V G+A+Y+  +LD  F    Y+
Sbjct: 950  PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK 1009

Query: 637  KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKEN 696
             ++ K  T  D+       Y SL+ +LE   N   ++ + F I + +LFG    ++LK  
Sbjct: 1010 MMLHKPITLHDMESVDSEYYNSLRWILE---NDPTELDLRFIIDE-ELFGQTHQHELKNG 1065

Query: 697  GDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLI 756
            G +I +TN+N+KE++ L   +     ++KQ  AF+ GF  +  +  +K +F   E+ELL+
Sbjct: 1066 GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIK-IFDENELELLM 1124

Query: 757  CGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGG 816
            CG  ++D     E T+Y  GY+ +  +I+ FW+ V     E++   LQF TGT R P+ G
Sbjct: 1125 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG 1184

Query: 817  LGKLKMIIAKNGPDT---------ERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAK 867
              +L      NGP +         E+LP +HTCFN L LP Y S E+L ++L  AI   +
Sbjct: 1185 FAEL---YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241

Query: 868  GF 869
            GF
Sbjct: 1242 GF 1243


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
           sapiens]
          Length = 862

 Score =  201 bits (511), Expect = 2e-51
 Identities = 124/364 (34%), Positives = 202/364 (55%), Gaps = 21/364 (5%)

Query: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
           ++++ V R  + +D+    + I   +P DL+++L+V F GE+G+D GGV++E+F L+  E
Sbjct: 506 HIKITVTRKTLFEDSF---QQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 562

Query: 579 IFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVV 634
           + NP   +F Y  +       NP+S+        F  IG  + +A+++   +D  F +  
Sbjct: 563 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 622

Query: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDL 693
           Y++++ K    +DL    P  Y SL  +   E N+E+ D+ + F + + ++ G    +DL
Sbjct: 623 YKRILNKPVGLKDLESIDPEFYNSL--IWVKENNIEECDLEMYFSVDK-EILGEIKSHDL 679

Query: 694 KENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 753
           K NG  I +T EN++E++ + +++ L++ VE+Q +AF  GF+ +  +  L+Y F  +E+E
Sbjct: 680 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQY-FDAKELE 738

Query: 754 LLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP 813
           +L+CG + +D    +    Y   Y R S  I  FW+ V    +E++   LQF TGT R P
Sbjct: 739 VLLCGMQEIDLNDWQRHAIY-RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLP 797

Query: 814 VGGL-------GKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYA 866
           VGG        G  K  I K G +   LP SHTCFN L LP Y S E+LKE+LL AI   
Sbjct: 798 VGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856

Query: 867 KGFG 870
           +GFG
Sbjct: 857 EGFG 860


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
           sapiens]
          Length = 757

 Score =  197 bits (502), Expect = 3e-50
 Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)

Query: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
           + R++V R+ I +++      I    P DLKK+L V+F GE+G+D GGV++E+  L+  E
Sbjct: 398 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 454

Query: 579 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 634
           + NP  G+F Y  ++  +   NP S    +    F  +G ++GLA+++   ++  F +  
Sbjct: 455 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 514

Query: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 694
           Y++L+GK     DL    P L++SL  +LE   ++   +  TF +   + FG  + ++LK
Sbjct: 515 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 571

Query: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
            NG  +P+T EN+KE+V LY ++   + +E QF A ++GF+ +  +  LK  F  +E+EL
Sbjct: 572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 630

Query: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
           +I G   +D    +  T        DS ++R FW+ V +F +E++   LQF TG+ R P+
Sbjct: 631 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 689

Query: 815 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 864
            G   L+      GP          +T+ LP +HTCFN + +P Y S EKL E+LL A+ 
Sbjct: 690 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 749

Query: 865 YAKGFGM 871
              GF +
Sbjct: 750 ETCGFAV 756


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
           sapiens]
          Length = 731

 Score =  197 bits (502), Expect = 3e-50
 Identities = 121/367 (32%), Positives = 201/367 (54%), Gaps = 22/367 (5%)

Query: 519 YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEE 578
           + R++V R+ I +++      I    P DLKK+L V+F GE+G+D GGV++E+  L+  E
Sbjct: 372 HCRIEVSREEIFEESY---RQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHE 428

Query: 579 IFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 634
           + NP  G+F Y  ++  +   NP S    +    F  +G ++GLA+++   ++  F +  
Sbjct: 429 MLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPF 488

Query: 635 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLK 694
           Y++L+GK     DL    P L++SL  +LE   ++   +  TF +   + FG  + ++LK
Sbjct: 489 YKQLLGKPIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH-NAFGRILQHELK 545

Query: 695 ENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIEL 754
            NG  +P+T EN+KE+V LY ++   + +E QF A ++GF+ +  +  LK  F  +E+EL
Sbjct: 546 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLK-PFDQKELEL 604

Query: 755 LICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPV 814
           +I G   +D    +  T        DS ++R FW+ V +F +E++   LQF TG+ R P+
Sbjct: 605 IIGGLDKIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPL 663

Query: 815 GGLGKLKMIIAKNGP----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 864
            G   L+      GP          +T+ LP +HTCFN + +P Y S EKL E+LL A+ 
Sbjct: 664 QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE 723

Query: 865 YAKGFGM 871
              GF +
Sbjct: 724 ETCGFAV 730


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  197 bits (501), Expect = 4e-50
 Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)

Query: 450  PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 508
            PL   L++  +     V  E + + +T  PF++          ++ R++++ +R I    
Sbjct: 661  PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710

Query: 509  SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 564
              VQG    P+L    + +RR++I +DA  +L   + EN  DLKK++ V      G+DE 
Sbjct: 711  QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765

Query: 565  ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 614
                GG+ +EF   +++  FNP+ G F T +E   L + NP++    G      +  +G 
Sbjct: 766  GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823

Query: 615  VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 672
            +LG A+Y N ++++ F      KL+G         L    P +Y++L  L  YE +VE+ 
Sbjct: 824  MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882

Query: 673  MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 732
            + + F +   DL G   + +LK  G  IP+T+ NR  +++L +DY LN+ + +   AFR+
Sbjct: 883  LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941

Query: 733  GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 791
            G   V +   L+ +F  +EI++LI G++  +  + L+  T Y GGY+ D  +I+ FW +V
Sbjct: 942  GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000

Query: 792  HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 849
              FTDE+KR  L+F T   R P+ G  +L     I   G D ERLPT+ TC N+L LPE+
Sbjct: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060

Query: 850  SSKEKLKERLLKAITYAKGF 869
              +  L+ +LL AI  A GF
Sbjct: 1061 YDETLLRSKLLYAIECAAGF 1080


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
           sapiens]
          Length = 748

 Score =  193 bits (490), Expect = 7e-49
 Identities = 123/373 (32%), Positives = 198/373 (53%), Gaps = 19/373 (5%)

Query: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
           L Q Q    + R++V R+ I +++      +    P DL K+L ++F GE+G+D GGV++
Sbjct: 383 LSQQQPQAGHCRIEVSREEIFEESY---RQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAR 439

Query: 570 EFFQLVVEEIFNPDIGMFTYD-ESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 625
           E+  L+  E+ NP  G+F Y  +       NP S    E    F  +G ++G+A+++   
Sbjct: 440 EWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHY 499

Query: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
           +D  F +  Y++L+GK  T  D+    P L+ SL  +LE   ++   +  TF +   + +
Sbjct: 500 IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILE--NDITGVLDHTFCVEH-NAY 556

Query: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
           G  + ++LK NG  IP+  EN+KE+V LY ++   + +E QF A ++GF+ V  +  LK 
Sbjct: 557 GEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLK- 615

Query: 746 LFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQF 805
            F  +E+EL+ICG   +D    +  T      T DS +++ FW+ V  F +E++   LQF
Sbjct: 616 TFDEKELELIICGLGKIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQF 674

Query: 806 TTGTDRAPV-------GGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKER 858
            TG+ R P+       G  G     I +    T  LP +HTCFN + +P Y S EKL E+
Sbjct: 675 VTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEK 734

Query: 859 LLKAITYAKGFGM 871
           LL AI    GF +
Sbjct: 735 LLTAIEETCGFAV 747


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  192 bits (487), Expect = 1e-48
 Identities = 121/353 (34%), Positives = 191/353 (54%), Gaps = 19/353 (5%)

Query: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581
           L V RD I   +    E+++  N A LK+ + V F GE+G+ +G V +E+F ++  EI N
Sbjct: 555 LLVHRDSIFRSSC---EVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVN 610

Query: 582 PDIGMFTYDESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVYRKL 638
           PD  +FT       F  N +S+        F   G +LGLA+ +  +++++F    Y+ +
Sbjct: 611 PDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHI 670

Query: 639 MGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVED-DMMITFQISQTDLFGNPMMYDLKENG 697
           +G    ++D+    P   ++L+ +L+   ++ D  + +TF + +TD+FG      LK  G
Sbjct: 671 LGIPVNYQDVASIDPEYAKNLQWILD--NDISDLGLELTFSV-ETDVFGAMEEVPLKPGG 727

Query: 698 DKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLIC 757
             I +T  N+ E+V L ++  + ++++ Q  AF +GFHM    S ++ LF   E+ELL+ 
Sbjct: 728 GSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQ-LFDEYELELLLS 786

Query: 758 GSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAP---- 813
           G   +D     + TEY  GY R+  +I+ FWE+V   T E++ L LQF TG+ R P    
Sbjct: 787 GMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGF 846

Query: 814 ---VGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAI 863
              +GG G     IA        LPTS TC N+L LPEY SKE LK+RLL A+
Sbjct: 847 ANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,917,366
Number of Sequences: 37866
Number of extensions: 1449222
Number of successful extensions: 7270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 6788
Number of HSP's gapped (non-prelim): 326
length of query: 872
length of database: 18,247,518
effective HSP length: 111
effective length of query: 761
effective length of database: 14,044,392
effective search space: 10687782312
effective search space used: 10687782312
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.