Guide to the Human Genome
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Search of human proteins with 194294523

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
         (1670 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                  3332   0.0  
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                  3318   0.0  
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                  2395   0.0  
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]              1966   0.0  
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]              1170   0.0  
gi|10864047 epidermal growth factor receptor pathway substrate 1...   151   4e-36
gi|148746195 trichohyalin [Homo sapiens]                              131   6e-30
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...   127   1e-28
gi|4503593 epidermal growth factor receptor pathway substrate 15...   125   3e-28
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]        125   3e-28
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]        125   3e-28
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]        125   3e-28
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...   120   1e-26
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...   120   1e-26
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                      118   5e-26
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...   114   6e-25
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...   114   6e-25
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...   114   6e-25
gi|194473700 Src homology 3 domain-containing guanine nucleotide...   112   3e-24
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              109   3e-23
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]            109   3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   107   1e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   107   1e-22
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...   107   1e-22
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...   107   1e-22
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...   107   1e-22
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   106   2e-22
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...   106   2e-22
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...   106   2e-22
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...   106   2e-22

>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 3332 bits (8640), Expect = 0.0
 Identities = 1670/1670 (100%), Positives = 1670/1670 (100%)

Query: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
            MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60

Query: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
            EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120

Query: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
            SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180

Query: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
            PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240

Query: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
            PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300

Query: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
            EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360

Query: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
            VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420

Query: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
            ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480

Query: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
            IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540

Query: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
            QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600

Query: 601  ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660
            ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK
Sbjct: 601  ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660

Query: 661  LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK 720
            LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK
Sbjct: 661  LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK 720

Query: 721  AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW 780
            AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW
Sbjct: 721  AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW 780

Query: 781  FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
            FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL
Sbjct: 781  FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840

Query: 841  TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 900
            TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV
Sbjct: 841  TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 900

Query: 901  LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI 960
            LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI
Sbjct: 901  LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI 960

Query: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK 1020
            ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK 1020

Query: 1021 SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
            SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF
Sbjct: 1021 SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080

Query: 1081 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1140
            PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG
Sbjct: 1081 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1140

Query: 1141 EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD 1200
            EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD
Sbjct: 1141 EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD 1200

Query: 1201 LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI 1260
            LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI
Sbjct: 1201 LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI 1260

Query: 1261 GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL 1320
            GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL
Sbjct: 1261 GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL 1320

Query: 1321 LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW 1380
            LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW
Sbjct: 1321 LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW 1380

Query: 1381 IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ 1440
            IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ
Sbjct: 1381 IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ 1440

Query: 1441 FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD 1500
            FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD
Sbjct: 1441 FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD 1500

Query: 1501 NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN 1560
            NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN
Sbjct: 1501 NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN 1560

Query: 1561 GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF 1620
            GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF
Sbjct: 1561 GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF 1620

Query: 1621 LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL 1670
            LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
Sbjct: 1621 LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL 1670


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 3318 bits (8602), Expect = 0.0
 Identities = 1670/1697 (98%), Positives = 1670/1697 (98%), Gaps = 27/1697 (1%)

Query: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
            MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60

Query: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
            EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120

Query: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
            SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180

Query: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
            PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240

Query: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
            PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300

Query: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
            EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360

Query: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
            VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420

Query: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
            ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480

Query: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
            IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540

Query: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
            QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600

Query: 601  ALEKETASKLSEMDSFNNQLK---------------------------ELRETYNTQQLA 633
            ALEKETASKLSEMDSFNNQLK                           ELRETYNTQQLA
Sbjct: 601  ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660

Query: 634  LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
            LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661  LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720

Query: 694  EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
            EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721  EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780

Query: 754  GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
            GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781  GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840

Query: 814  TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
            TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841  TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900

Query: 874  LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
            LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901  LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960

Query: 934  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
            REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020

Query: 994  SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
            SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080

Query: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
            LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140

Query: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
            NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200

Query: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1233
            DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1260

Query: 1234 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1293
            IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD
Sbjct: 1261 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1320

Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
            EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380

Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
            ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440

Query: 1414 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1473
            LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV
Sbjct: 1441 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1500

Query: 1474 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1533
            KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA
Sbjct: 1501 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1560

Query: 1534 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1593
            RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC
Sbjct: 1561 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1620

Query: 1594 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1653
            QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG
Sbjct: 1621 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1680

Query: 1654 EVWVRFDLQLFEQKTLL 1670
            EVWVRFDLQLFEQKTLL
Sbjct: 1681 EVWVRFDLQLFEQKTLL 1697


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 2395 bits (6206), Expect = 0.0
 Identities = 1209/1242 (97%), Positives = 1211/1242 (97%), Gaps = 27/1242 (2%)

Query: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
            MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1    MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60

Query: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
            EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61   EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120

Query: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
            SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121  SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180

Query: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
            PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181  PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240

Query: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
            PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241  PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300

Query: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
            EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301  EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360

Query: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
            VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361  VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420

Query: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
            ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421  ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480

Query: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
            IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481  IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540

Query: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
            QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541  QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600

Query: 601  ALEKETASKLSEMDSFNNQ---------------------------LKELRETYNTQQLA 633
            ALEKETASKLSEMDSFNNQ                           LKELRETYNTQQLA
Sbjct: 601  ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660

Query: 634  LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
            LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661  LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720

Query: 694  EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
            EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721  EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780

Query: 754  GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
            GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781  GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840

Query: 814  TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
            TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841  TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900

Query: 874  LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
            LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901  LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960

Query: 934  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
            REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961  REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020

Query: 994  SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
            SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080

Query: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
            LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140

Query: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
            NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200

Query: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAES 1215
            DTMQPIERKRQGYIHELIQTEERYMADLQLVVEV +  +A S
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASS 1242


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 1966 bits (5093), Expect = 0.0
 Identities = 1049/1756 (59%), Positives = 1296/1756 (73%), Gaps = 127/1756 (7%)

Query: 2    MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
            MAQFPT   G  ++WAIT EER KHD+QF +LKP  G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1    MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60

Query: 62   IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
            IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP  LPP+MKQ P+      A FGMG 
Sbjct: 61   IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119

Query: 122  MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
            + ++          P+T+++    G+ +P + M   LV SV T+++P   NG   +IQPL
Sbjct: 120  IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169

Query: 179  P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
            P   + ++TLP  SS+S    G      +QKAQS  D+ S    +               
Sbjct: 170  PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213

Query: 237  EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
            EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR  L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214  EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273

Query: 297  LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
            L AEEFILAMHL D+A +GQPLP  LPPE +PPSFR    G  I  I+ T     LP   
Sbjct: 274  LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333

Query: 349  KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
             +++E+ Q  KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334  VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393

Query: 407  KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
            K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394  KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453

Query: 467  RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
            RQELLNQ+N+EQE+IV L +KKK L  ELEALN K  Q+ G+LQD+R +  TQ+ E+E  
Sbjct: 454  RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513

Query: 527  DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKS 585
            +K  +L I EI  LQQ+LQE Q  L  L+PEKQ+LN+++K +Q ++   DS V+L  K++
Sbjct: 514  NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571

Query: 586  LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
            LE +EL  Q L++QLD +EKET SKL E+D FNNQLKELRE +N QQL  ++  + +R K
Sbjct: 572  LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLK 631

Query: 645  LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE--------EKQKRLQEEK 696
             KE ERK +EL ++K   +EA R+A++ ++  W E++++E+E        E++K  +EE 
Sbjct: 632  QKEQERKIIELEKQK---EEAQRRAQE-RDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687

Query: 697  TQEKIQEEERKAE----------EKQRKDKDTLKAE----EKKRETASV-----LVNYRA 737
             ++K  EE+ K E          + Q   K  ++A     EK   T S      +V YRA
Sbjct: 688  VKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRA 747

Query: 738  LYPFEARNHDEMSFNSGDIIQV-----DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS 792
            LYPFE+R+HDE++   GDI+ V     DE   GEPGWL G  +G  GWFP NY EK+P +
Sbjct: 748  LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807

Query: 793  E----------NEKAVSPKKALLPPTVSLSATST-------------SSEPLSSNQPASV 829
            E          +  A +PK AL      L+ TS+             S+ P S+N+    
Sbjct: 808  EVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPET 867

Query: 830  TDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPGSV-SPIHGQGQVVENLKAQALCSWTAK 885
             ++    +  +LTV ++ Q  ++SAFT   + GS  SP+ GQG+ VE L+AQAL  W AK
Sbjct: 868  DNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAK 927

Query: 886  KDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKR--------EEP 937
            KDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GWFPKSYVK+I G   K         E P
Sbjct: 928  KDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESP 987

Query: 938  EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGD 997
             +L    +  P +     GEE+IA+Y Y S E GDLTF +G+ ILVT+KDG+WWTG++GD
Sbjct: 988  ASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGD 1045

Query: 998  RSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILK 1057
            ++G+FPSNYV+ KD E  G+A K+G+  KKPEIAQV ++Y A+G EQL+LAPGQLILI K
Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105

Query: 1058 KNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQVIAMYD 1110
            KN  GWW+GELQARGKKRQ GWFPA++VKLL P + + TP   P       VCQVI MYD
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165

Query: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADL 1170
            Y A N+DEL+F+KGQ+INV+NK+DPDWW+GE+NG  GLFPSNYVK+TTD DPSQQWC+DL
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDL 1225

Query: 1171 QTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNW 1230
              LD + P ERKRQGYIHELI TEE Y+ DLQLV E+FQK + ES  LTE E+A+IFVNW
Sbjct: 1226 HLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNW 1285

Query: 1231 KELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQ 1290
            KELIM N KLLKALRVRKK  GEKMPV+MIGDIL+A+L HMQ YIRFCS QLNGAAL+QQ
Sbjct: 1286 KELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQ 1345

Query: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
            KTDE  DFKEF+K+LA DPRCKGMPLSSF+LKPMQR+TRYPL+I++ILENTPE+H DHS 
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405

Query: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLH 1410
            LK ALE+AEELCSQVNEGVREKENSDRLEWIQAHVQCEGL+EQL+FNS+TNCLGPRK LH
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLH 1465

Query: 1411 SGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNE 1470
            SGKLYK KSNKEL+GFLFNDFLLLT + K    SSG++K+FS KSN Q+KMYKTPIFLNE
Sbjct: 1466 SGKLYKAKSNKELYGFLFNDFLLLTQITKPLG-SSGTDKVFSPKSNLQYKMYKTPIFLNE 1524

Query: 1471 VLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKA 1530
            VLVKLPTDPS DEP+FHISHIDRVYTLR ++INERTAWVQKIKAASE YI+TEKKKREKA
Sbjct: 1525 VLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKA 1584

Query: 1531 YQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWN 1590
            Y  RSQ+ +GIGRLMV+V+E  ELK C+ +GKSNPYCE++MGSQ + T+TIQDTLNPKWN
Sbjct: 1585 YLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWN 1644

Query: 1591 FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEV 1650
             NCQFFI+DL Q+VLC+T+F+RDQFSPDDFLGRTEI VA I+ +Q SKGP+T+ LLLHEV
Sbjct: 1645 SNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEV 1704

Query: 1651 PTGEVWVRFDLQLFEQ 1666
            PTGE+ VR DLQLF++
Sbjct: 1705 PTGEIVVRLDLQLFDE 1720


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 1170 bits (3026), Expect = 0.0
 Identities = 662/1255 (52%), Positives = 852/1255 (67%), Gaps = 126/1255 (10%)

Query: 2    MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
            MAQFPT   G  ++WAIT EER KHD+QF +LKP  G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1    MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60

Query: 62   IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
            IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP  LPP+MKQ P+      A FGMG 
Sbjct: 61   IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119

Query: 122  MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
            + ++          P+T+++    G+ +P + M   LV SV T+++P   NG   +IQPL
Sbjct: 120  IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169

Query: 179  P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
            P   + ++TLP  SS+S    G      +QKAQS  D+ S    +               
Sbjct: 170  PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213

Query: 237  EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
            EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR  L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214  EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273

Query: 297  LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
            L AEEFILAMHL D+A +GQPLP  LPPE +PPSFR    G  I  I+ T     LP   
Sbjct: 274  LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333

Query: 349  KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
             +++E+ Q  KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334  VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393

Query: 407  KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
            K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394  KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453

Query: 467  RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
            RQELLNQ+N+EQE+IV L +KKK L  ELEALN K  Q+ G+LQD+R +  TQ+ E+E  
Sbjct: 454  RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513

Query: 527  DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
            +K  +L I EI  LQQ+LQE Q  L  L+PEKQ+LN+++K +Q ++   DS V+L  K++
Sbjct: 514  NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571

Query: 586  LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
            LE +EL  Q L++QLD +EKET SKL E+D FNNQLKELRE +N QQL  ++  + +R K
Sbjct: 572  LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLK 631

Query: 645  LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE--------EKQKRLQEEK 696
             KE ERK +EL   +K ++EA R+A Q ++  W E++++E+E        E++K  +EE 
Sbjct: 632  QKEQERKIIEL---EKQKEEAQRRA-QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687

Query: 697  TQEKIQEEERKAE----------EKQRKDKDTLKA----EEKKRETASV-----LVNYRA 737
             ++K  EE+ K E          + Q   K  ++A     EK   T S      +V YRA
Sbjct: 688  VKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRA 747

Query: 738  LYPFEARNHDEMSFNSGDIIQ-----VDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS 792
            LYPFE+R+HDE++   GDI+      VDE   GEPGWL G  +G  GWFP NY EK+P +
Sbjct: 748  LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807

Query: 793  E----------NEKAVSPKKALLPPTVSLSATS-------------TSSEPLSSNQPASV 829
            E          +  A +PK AL      L+ TS             +S+ P S+N+    
Sbjct: 808  EVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPET 867

Query: 830  TDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG-SVSPIHGQGQVVENLKAQALCSWTAK 885
             ++    +  +LTV ++ Q  ++SAFT   + G S SP+ GQG+ VE L+AQAL  W AK
Sbjct: 868  DNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAK 927

Query: 886  KDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK--------REEP 937
            KDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GWFPKSYVK+I G   K         E P
Sbjct: 928  KDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESP 987

Query: 938  EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGD 997
             +L    +  P +     GEE+IA+Y Y S E GDLTF +G+ ILVT+KDG+WWTG++GD
Sbjct: 988  ASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGD 1045

Query: 998  RSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILK 1057
            ++G+FPSNYV+ KD E  G+A K+G+  KKPEIAQV ++Y A+G EQL+LAPGQLILI K
Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105

Query: 1058 KNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQVIAMYD 1110
            KN  GWW+GELQARGKKRQ GWFPA++VKLL P + + TP   P       VCQVI MYD
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165

Query: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQ 1165
            Y A N+DEL+F+KGQ+INV+NK+DPDWW+GE+NG  GLFPSNYVK+TTD DPSQQ
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQ 1220


>gi|10864047 epidermal growth factor receptor pathway substrate
           15-like 1 [Homo sapiens]
          Length = 864

 Score =  151 bits (382), Expect = 4e-36
 Identities = 143/547 (26%), Positives = 246/547 (44%), Gaps = 110/547 (20%)

Query: 16  WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
           WA+  EE+ K D  F++L P  G ++GD+ +   + S LP  VL  +W LSD++KDG +D
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180

Query: 76  QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
           + EF++AM L+   L+                                     +P+P A 
Sbjct: 181 RDEFAVAMHLVYRALE------------------------------------KEPVPSA- 203

Query: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSS--STLPHGSSY 193
                        LPP ++P    PS    ++  G   ++   P P  S  ST  HGS  
Sbjct: 204 -------------LPPSLIP----PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVS 246

Query: 194 SLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFN 253
           SL                    S+ S S   SL    P   T  W VP   ++++ + F 
Sbjct: 247 SL-------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFL 284

Query: 254 TLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMA 312
             D  + GY+SG + +   + S L+Q  LA IW LAD    G+L  ++F LAM+ +    
Sbjct: 285 KTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKV 344

Query: 313 KAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYE 372
             G   P  L P++VPPS RG    DS +G+L S     E    K+L    ++  +   E
Sbjct: 345 SKGIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQRE 399

Query: 373 RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL 432
           + ++E + R +   E+  R+   + Q+ + + +R+   LQE E +KQ + + RL+   E+
Sbjct: 400 KYSLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EM 452

Query: 433 ERQREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKK 488
           ++Q+ + R    + R+  + E +    L+ + + +  +L +Q+   NR + E+ RL  ++
Sbjct: 453 DQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEE 512

Query: 489 KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----L 544
             L   ++A         GR+Q   + K  + T+ E+   Q   ++ ++ + +QE    L
Sbjct: 513 TQLEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSL 561

Query: 545 QEYQNKL 551
           ++Y   L
Sbjct: 562 EQYDQVL 568



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)

Query: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
           +P +  + WAV    + K+   F +L   ++G LSG + +  L+ S L    L  +W L+
Sbjct: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171

Query: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
           D+D DG L  +EF +AMHL   A   +P+P  LPP L+PPS R
Sbjct: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 43/200 (21%), Positives = 85/200 (42%), Gaps = 32/200 (16%)

Query: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
           ++I + +  K  LE+  R + E IR+     QEL N  +RE   +  L ++K++    L+
Sbjct: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450

Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
            ++ +  ++   L DVR K Q +   +  L  Q   +  ++K  + +L            
Sbjct: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL------------ 498

Query: 557 EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSF 616
                          N   S ++ L ++  + E+  Q  + QL+ + K   S   E++  
Sbjct: 499 ---------------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA 543

Query: 617 NNQLKELRETYNTQQLALEQ 636
            ++L +L E+      +LEQ
Sbjct: 544 RSKLSQLHESRQEAHRSLEQ 563



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
           Y   +  +D + +G +   +A   L +S LS   L  IW LAD +G G L  + F +A+ 
Sbjct: 19  YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78

Query: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
           L   A++G  + L+ L   + PP F
Sbjct: 79  LVACAQSGHEVTLSNLNLSMPPPKF 103


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  131 bits (329), Expect = 6e-30
 Identities = 111/427 (25%), Positives = 215/427 (50%), Gaps = 49/427 (11%)

Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR-----------EAERK 396
           +K+QEEEPQ++  +  E+++    ER   EL + RQ   +QQQR           E ER+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 397 AQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
            Q+E+   ++++RE QE+  ++QL  E+   ++++L R++EEERR+   RRE  ++  E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375

Query: 457 QRRLEWERIRRQEL-------------LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQ 503
           Q R E +  R Q+L               Q+ R ++++ R    ++   L  E    +H+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435

Query: 504 QISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQEL-----QEYQNKLIYLVPEK 558
           Q   + +  +  K+ Q+   + L ++ + E  E ++ +Q+L     +E + + + L  E+
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----------EQLDALEKETAS 608
           +   +  +  Q     +       K+  E+E L QRL+          E+ + L K    
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555

Query: 609 KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIER--KRLELMQKKKLEDEAA 666
           K  E +    +LK  +E    Q L  E+  + +R K ++ ER  +RL+  + ++LE E  
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 667 R----KAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA- 721
           R    K ++ +E   ++ L+ EE+E++++ Q  + Q++ +E+  K EE++ + +  LK  
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675

Query: 722 -EEKKRE 727
            EE++RE
Sbjct: 676 HEEERRE 682



 Score =  120 bits (302), Expect = 8e-27
 Identities = 110/410 (26%), Positives = 209/410 (50%), Gaps = 46/410 (11%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-------- 399
            Q   EE  Q++     E++ K    R   E EK  Q L E++Q +   +AQ+        
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856

Query: 400  -EKEEWERKQRELQEQEWKKQLE---------------LEKRLEKQRELERQREEERRKD 443
             E +E  R Q + ++Q+W+ QLE               L+++L K+++L ++ EEE +++
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 444  IERREAAKQELERQRRLEWERIRRQELLNQKNREQ---EEIVRLNSKKKNLHLELEALNG 500
             ER +  +QE ERQ R E +  + +E L ++ RE+   +E  R   K K L  + E L G
Sbjct: 917  -EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975

Query: 501  KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL 560
            +  +   R +  R KK  ++ EL+  ++Q   E  E ++ Q+  ++Y+ K      E+QL
Sbjct: 976  EEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033

Query: 561  LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL 620
            L E  +  +             ++   +EE  Q+ +EQL   E+ET  +  E++    + 
Sbjct: 1034 LREEREKRRLQE---------RERQYREEEELQQEEEQLLGEERETRRR-QELERQYRKE 1083

Query: 621  KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGKENLWK 678
            +EL++    +QL  E+  K +R + +   R+  EL Q+++  L +E  ++ +Q  E  ++
Sbjct: 1084 EELQQ--EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 679  ENLRKEEEEKQK-RLQEEK-TQEKIQEEERKAEEKQRKDKDTLKAEEKKR 726
            E    ++EE+Q  R + EK  +++++ + R+ EE Q++++  L+ E++KR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191



 Score =  115 bits (289), Expect = 3e-25
 Identities = 108/421 (25%), Positives = 218/421 (51%), Gaps = 33/421 (7%)

Query: 346  SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQRE--AERKAQKEK-- 401
            ++++ QEEE ++     ++ + K+  ERG   L   R  L EQ++R+  AE + Q+E+  
Sbjct: 754  AHRQQQEEEQRRDFTWQWQAEEKS--ERGRQRL-SARPPLREQRERQLRAEERQQREQRF 810

Query: 402  --EEWERKQRELQEQEWKKQ---LELEKRLEKQRELERQREEE--RRKDIERREAAKQEL 454
              EE E++QR  Q +E +K+   LE E++L+++   ++ +EEE   ++D ERR + +Q  
Sbjct: 811  LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870

Query: 455  ERQRR--LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
            +++ R  LE ER RR+  L  K   QE++ +     +    EL+    + ++   + +  
Sbjct: 871  DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 513  RLKKQTQKTELEVLDKQCDLEIMEIKQLQ----QELQEYQNKLIYLVPEKQLLNERIKNM 568
            R ++Q Q+ E ++L ++ +    + ++ Q    ++LQ+ + +L+   PEK+   ER K  
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 569  QFSNTPDSGVSLLHKKSLEKE-----ELCQRLKEQLDALEKETASKLSEMDSFNNQLKEL 623
            +           L ++  EK      E   R K++L   E++   +  E      + ++ 
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 624  RETYNTQ----QLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGKENLW 677
            RE    Q    QL  E+    +R +L+   RK  EL Q+++  L +E  ++ +Q +E   
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110

Query: 678  K--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY 735
            +  E L++EEE+  +  +E++ +++++ + R+ EE Q++++  L+ E +KR    +   Y
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170

Query: 736  R 736
            R
Sbjct: 1171 R 1171



 Score =  109 bits (272), Expect = 3e-23
 Identities = 99/400 (24%), Positives = 196/400 (49%), Gaps = 36/400 (9%)

Query: 348 QKMQEEEPQKKLPVTFEDKR---KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
           QK ++E  +++L    E++R   K   E    E E+R+Q L   Q+ E   +  K +EE 
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
            R+Q+E +EQ    QL  E+   +++ L+RQ EEER   +++R  ++Q+L R++    E+
Sbjct: 496 RREQQERREQ----QLRREQEERREQRLKRQEEEER---LQQRLRSEQQLRREQEERREQ 548

Query: 465 I--RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
           +  R +E   ++ R ++ + R   ++++  L+ E    + QQ   R Q+ RL+++ ++ E
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKRE--EERRQQRLKREQEERLEQRLKREE 606

Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
           +E L+++   E    ++L++E  E + +   L  E+Q   E  +  Q             
Sbjct: 607 VERLEQEERRE----QRLKREEPEEERRQQLLKSEEQ---EERRQQQLRREQQERREQRL 659

Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQ---QLALEQLYK 639
           K+  E+E L QRLK + +   +E      E +    ++K     +  Q   +    Q   
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719

Query: 640 IKRDKLKEIERKRLELMQKKK--------LEDEAARKAKQGKEN----LWKENLRKEEEE 687
             R + +E +R+R E  +K++         E+E A + +Q +E      W+    ++ E 
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779

Query: 688 KQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
            ++RL       + +E + +AEE+Q++++  L  EE+K +
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819



 Score =  107 bits (266), Expect = 1e-22
 Identities = 90/384 (23%), Positives = 195/384 (50%), Gaps = 77/384 (20%)

Query: 352  EEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE----KEEWERK 407
            +E+ +K+  +  E++ +   E    E EKRR+   E+Q RE E+  Q+E    +EE E++
Sbjct: 896  QEQLRKEQQLLQEEEEELQRE----EREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951

Query: 408  QRELQEQEWKKQLELEKRLE--------KQRELERQRE--EERRKDIERREAAKQELERQ 457
            +R+ +E++++K  +L+++ E        K+R  ER+++  EE     E  +  ++E E++
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 458  RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQD 511
            RR EWER  R++  ++  +E+E+++R   +K+ L      + E E L  + +Q+ G  ++
Sbjct: 1012 RRQEWERQYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069

Query: 512  VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
             R +++ ++                  + ++ELQ+ + +L+   PEK+   ER       
Sbjct: 1070 TRRRQELERQ----------------YRKEEELQQEEEQLLREEPEKRRRQER------- 1106

Query: 572  NTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQ 631
                       ++   +EE  Q+ +EQL   E+E             + +EL   Y  ++
Sbjct: 1107 -----------ERQCREEEELQQEEEQLLREERE-----------KRRRQELERQYREEE 1144

Query: 632  LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKR 691
               ++  ++ R+   E E++R + ++++  E+E   + +Q +E L +E   K  +E++++
Sbjct: 1145 EVQQEEEQLLRE---EPEKRRRQELERQYREEE---ELQQEEEQLLREEQEKRRQERERQ 1198

Query: 692  LQEEKTQEKIQEEERKAEEKQRKD 715
             +EE+  ++ + ++R  +E QR D
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSD 1222



 Score =  106 bits (265), Expect = 2e-22
 Identities = 108/412 (26%), Positives = 209/412 (50%), Gaps = 55/412 (13%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE----- 402
            ++ Q  E +K+L    E+++    ER   +L++    L E Q+R   ++ +++++     
Sbjct: 820  RRRQRREREKELQFLEEEEQLQRRERAQ-QLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878

Query: 403  EWERKQRE--------LQEQ---------EWKKQLELEKRLEKQR-ELERQREEERRKDI 444
            E ERK+R         LQEQ         E +++L+ E+R +++R E ERQ  EE +   
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 445  ERREAAKQELERQRRLEWER-IRRQELLNQKNRE---QEEIVRLNSKKKNLHLELEALNG 500
            E  +  ++E E++RR E ER  R+ + L QK  +   +E   R   +++  + E E L  
Sbjct: 939  EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998

Query: 501  KHQQISGRLQDVRLKKQ-----TQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLV 555
            + +Q+    ++ R +++      +K EL+  ++Q   E  E ++LQ+  ++Y+ +     
Sbjct: 999  EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058

Query: 556  PEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDS 615
             E+QLL E  +  +             ++   KEE  Q+ +EQL   E E   +  E + 
Sbjct: 1059 EEEQLLGEERETRRRQEL---------ERQYRKEEELQQEEEQLLREEPEKRRR-QERER 1108

Query: 616  FNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGK 673
               + +EL++    +QL  E+  K +R +L+   R+  E+ Q+++  L +E  ++ +Q  
Sbjct: 1109 QCREEEELQQ--EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166

Query: 674  ENLWK--ENLRKEE-----EEKQKRLQEEKTQEKIQEEERKAEEKQR-KDKD 717
            E  ++  E L++EE     EE++KR QE + Q + +EE ++ + KQR +D+D
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218



 Score =  105 bits (263), Expect = 3e-22
 Identities = 97/411 (23%), Positives = 209/411 (50%), Gaps = 27/411 (6%)

Query: 348 QKMQEEEPQKKLPVTFEDKR----KANYERGNMELEKRRQALMEQQ--QREAERKAQKEK 401
           +++++E  +++L    E++R    K   ER    L++ ++  +EQ+  + E ER  Q+E+
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
            E   K+ E +E+  ++ L+ E++ E++++  R+ ++ERR+   +RE  ++ LE++ + E
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675

Query: 462 WERIRR-QELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK 520
            E  RR QEL  ++  +  E ++    K    LE EA + +  ++  R +    +++ Q+
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA-DARQSKVYSRPRKQEGQRRRQE 734

Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP-EKQLLNERIKNMQFSNTPDSGVS 579
            E +   ++ +L+  E ++  ++ QE + +  +    + +  +ER +    +  P   + 
Sbjct: 735 QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP---LR 791

Query: 580 LLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYK 639
              ++ L  EE  QR +  L   E+E   +  +      +L+ L E    Q+    Q  +
Sbjct: 792 EQRERQLRAEERQQREQRFLPE-EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 640 IKRDKLKEIERKRLELMQKK------KLEDEAARK-----AKQG-KENLWKEN--LRKEE 685
            + D L+E + +R    Q++      +LE+E  R+     AK   +E L KE   L++EE
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910

Query: 686 EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYR 736
           EE Q+  +E++ +++ + + R+ E+ Q++++  L+ E +KR        YR
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961



 Score =  104 bits (259), Expect = 8e-22
 Identities = 110/453 (24%), Positives = 221/453 (48%), Gaps = 55/453 (12%)

Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMEL-----EKRRQALMEQQQREAERKAQKEKEEWE 405
           QEEE +++     E++R+   ER   +L     E+R Q L  Q++ E  ++  + +++  
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539

Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELER-QREEERRKD--IERREAAKQEL---ERQRR 459
           R+Q E +EQ  K+  E EKRLE++R  +R +RE+E R+D  ++R E  +Q+    E++ R
Sbjct: 540 REQEERREQLLKR--EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597

Query: 460 LEWERIRRQEL--LNQKNREQEEIVRLN---SKKKNLHLELEALNGKHQQISGRLQDVRL 514
           LE +R++R+E+  L Q+ R ++ + R      +++ L    E    + QQ+    Q+ R 
Sbjct: 598 LE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656

Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM------ 568
           ++  ++ E E L+++   E  E ++ +QEL E          E++   ERIK+       
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERR-EQELAE---------EEQEQARERIKSRIPKWQW 706

Query: 569 QFSNTPDSGVSLLH---------KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQ 619
           Q  +  D+  S ++         ++  E+EE  +R + +L   E+E A +  + +     
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 620 LK-----ELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKE 674
                  E +     Q+L+     + +R++    E ++    +    E+E  ++ +Q +E
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 675 NLWKENLRKEEEEKQKR-----LQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 729
              +    +EEE+ Q+R     LQEE+   +  +E R+++E++R  K   + EE+++   
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886

Query: 730 SVLVNYRALYPFEARNHDEMSFNSGDIIQVDEK 762
             L    AL   + R   ++     + +Q +E+
Sbjct: 887 HTLYAKPALQE-QLRKEQQLLQEEEEELQREER 918



 Score =  104 bits (259), Expect = 8e-22
 Identities = 97/422 (22%), Positives = 201/422 (47%), Gaps = 48/422 (11%)

Query: 338  DSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKA 397
            + I   +P +Q   E E   +    +   RK   +R   E E++R+    + Q + E +A
Sbjct: 695  ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754

Query: 398  QKEKEE--------WERKQRELQE-------------QEWKKQLELEKRLEKQREL--ER 434
             ++++E        W+ +  E  E             ++ ++QL  E+R ++++    E 
Sbjct: 755  HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814

Query: 435  QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS------KK 488
            + +E+RR+    RE   Q LE + +L+  R R Q+L  +++  QE+  R  S      +K
Sbjct: 815  EEKEQRRRQRREREKELQFLEEEEQLQ-RRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 489  KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQ 548
                LE E    +H   +      +L+K+ Q  + E  +++   E  E ++ Q++ ++Y+
Sbjct: 874  WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE--EEELQREEREKRRRQEQERQYR 931

Query: 549  NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETAS 608
             +      E+QLL E  +  +             ++   K++  Q+ +EQL   E E   
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQE---------RERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 609  KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAA 666
            +  E +    + +EL++    +QL  E+  K +R + +   RK+ EL Q+++  L +E  
Sbjct: 983  R-QEREKKYREEEELQQ--EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039

Query: 667  RKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEK 724
            ++  Q +E  ++  E L++EEE+     +E + +++++ + RK EE Q++++  L+ E +
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099

Query: 725  KR 726
            KR
Sbjct: 1100 KR 1101



 Score =  104 bits (259), Expect = 8e-22
 Identities = 101/397 (25%), Positives = 200/397 (50%), Gaps = 31/397 (7%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW--- 404
            +K +EEE Q  L     D++    E+     E+ R+ L E+QQ   ER  +  +EE    
Sbjct: 1414 RKFREEEQQ--LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471

Query: 405  ERKQRELQEQEW-KKQLELEKRLEKQRELERQREEERRKDIERRE--AAKQELERQRRL- 460
            ER++++L  QE  +K LE E++L +Q    + RE+E R     R+    +Q+L RQ+R  
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531

Query: 461  ----EWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
                E +++RRQE   Q+ ++++   R   +++ L  E E      QQ+S + +D + + 
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFR---EEEQLRQERE-----EQQLSRQERDRKFRL 1583

Query: 517  QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
            + QK   +  +++   +  ++++ + + Q  Q +      ++QLL ER +  Q       
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERD 1642

Query: 577  GVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
               L  +  L ++E  Q+L+   D   +E    L E +    + +E    +  ++   +Q
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE---QQ 1699

Query: 637  LYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQE 694
            L + +R++  L+E ++ R + +++K  E+E  R+  + ++   +E  RK  EE+Q R + 
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 695  EKTQEKIQEEERKAEE----KQRKDKDTLKAEEKKRE 727
            E+ Q + QE +RK  E    +Q +++  L+++E  R+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796



 Score =  103 bits (258), Expect = 1e-21
 Identities = 96/384 (25%), Positives = 195/384 (50%), Gaps = 34/384 (8%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR--EAERKAQKEKEEWE 405
            Q +QE E Q+      E  RK   E   +  ++R +   EQ+ R  E ERK  +E+++  
Sbjct: 1468 QLLQEREEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525

Query: 406  RKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
            R+QR+   LQE++  ++ E  ++  + R+ + + EE+ R++ E ++ ++QE +R+ RLE 
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585

Query: 463  ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
            +++RRQE   +K  E E+ +R    ++ L  E +    + +Q+    ++ +L +Q +   
Sbjct: 1586 QKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER--- 1641

Query: 523  LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
                D++   E  ++++ ++E Q   ++      E+QLL E  +        D       
Sbjct: 1642 ----DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD------- 1690

Query: 583  KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR 642
            +K  E+E+  +R + +   L++E   +  E++    + ++LR+    +QL  ++ Y+   
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR--- 1747

Query: 643  DKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ 702
             K+ E E+ R E  +++    E  RK ++      +E LR+E EE+Q R QE  +  K +
Sbjct: 1748 -KILEEEQLRPEREEQQLRRQERDRKFRE------EEQLRQEREEQQLRSQE--SDRKFR 1798

Query: 703  EEERKAEEKQRKDKDTLKAEEKKR 726
            EEE+  +E++ +     + + K R
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYR 1822



 Score =  103 bits (257), Expect = 1e-21
 Identities = 101/417 (24%), Positives = 212/417 (50%), Gaps = 45/417 (10%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
            ++ +++E +++   + E+K+    ER     EKRR+   +++ RE E+  Q+ +E+  R+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREERE----EKRRRQETDRKFREEEQLLQEREEQPLRR 1355

Query: 408  Q---RELQEQEWKKQLELEKRLEKQRELERQ-------REEERRKDIERREAAKQELERQ 457
            Q   R+ +E+E + Q +  K LE+++ L RQ       +EE++ +  ER +  +Q+ +R+
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 458  RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH------QQISGRLQD 511
             R E +++ RQE   +   E++++ R   ++K L  E +    +H      +Q+    ++
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475

Query: 512  VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER-----IK 566
             +L +Q +  +    ++Q   +  + K  +QEL+  + +  +L  E+QL  ++     ++
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535

Query: 567  NMQFSNTPDSGVSLLH---KKSLEKEELCQ-RLKEQLDALEKETASKLSEMD-------- 614
              Q     + G        +K  E+E+L Q R ++QL   E++   +L E          
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595

Query: 615  SFNNQLKELRETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQ--KKKLEDEAARKAK 670
             F    ++LR     QQL  E+  K + D+  L+E E ++L   +  +K LE+E   + +
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655

Query: 671  QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
            + ++ L  +  RK  EE+Q   + E+ Q + QE +RK  E++++    L+ +E++R+
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ----LRRQERERK 1708



 Score =  102 bits (255), Expect = 2e-21
 Identities = 106/405 (26%), Positives = 204/405 (50%), Gaps = 41/405 (10%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEW 404
            +K + +E +KK    + ++ +   E   +   E EKRR+   E+Q R+ + + Q+E+E+ 
Sbjct: 979  EKRRRQEREKK----YREEEELQQEEEQLLREEREKRRRQEWERQYRKKD-ELQQEEEQL 1033

Query: 405  ERKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERR----EAAKQELERQ 457
             R++RE   LQE+E + + E E + E+++ L  +RE  RR+++ER+    E  +QE E+ 
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093

Query: 458  RRLEWERIRRQELLNQKNRE-----QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
             R E E+ RRQE   Q   E     +EE +    ++K    ELE    + +++  + ++ 
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ-QEEEQ 1152

Query: 513  RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNE----RIKNM 568
             L+++ +K   + L++Q   E  E++Q +++L   + +      E+Q   E    R K  
Sbjct: 1153 LLREEPEKRRRQELERQY-REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211

Query: 569  QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYN 628
            Q     D    L  +   EKE   +  K      E E   +L +     +QL++ +   +
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED-----SQLRDRQSQQD 1266

Query: 629  TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQ--GKENLWKENLRKEEE 686
             Q L  EQ  + +  + +  +++     ++++LE E  ++AK+   K    K+ LR+E E
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326

Query: 687  EKQKRLQEEKTQEKIQEEERKAEEKQ-----RKDKDTLKAEEKKR 726
            EK++R   ++T  K +EEE+  +E++     R+++D    EE+ R
Sbjct: 1327 EKRRR---QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368



 Score =  100 bits (250), Expect = 9e-21
 Identities = 92/406 (22%), Positives = 204/406 (50%), Gaps = 46/406 (11%)

Query: 351  QEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEWERK 407
            +E+  +++L   + ++ +   E   +   E EKRR+  +E+Q RE E + Q+E+E+  R+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLRE 1186

Query: 408  QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDI------ERREAAK--------QE 453
            ++E + QE ++Q   E+ L++Q+  +R R+E++R D+      E+  A +        +E
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246

Query: 454  LERQRRLEWERIR-------RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
             E+ R+LE  ++R        Q LL ++     E  R   ++++ H   E    + +Q  
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306

Query: 507  GRLQDVRLKKQTQKTELEVLDK----QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLN 562
             + +D + +++ Q    E  +K    + D +  E +QL QE +E    L     +++   
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFRE 1364

Query: 563  ERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKE 622
            E +++ +             +K LE+E+  +R + +   L++E   +  E +    Q ++
Sbjct: 1365 EELRHQEQG-----------RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413

Query: 623  LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLR 682
             +     QQL+ ++  +  R++ +++ R+  E   +K LE+E   + ++ ++   +E L 
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERE---RKFLEEEQQLRQERHRKFREEEQLL 1470

Query: 683  KEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD-TLKAEEKKRE 727
            +E EE+Q   QE   +   +E++ + +E+ RK ++  L+++E +R+
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 89/392 (22%), Positives = 197/392 (50%), Gaps = 32/392 (8%)

Query: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWK------ 417
           +++++A  +     L+ RRQ   E Q+R   R  Q E+E  +R++++ QEQE +      
Sbjct: 96  DEEKRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153

Query: 418 ---KQLELEKRLEKQRELERQREEERRKDIERREAAKQEL------ERQRRLEWERIRRQ 468
              KQ  LE+R  ++R+ E  R+ +  ++ E R A +++L      E +   + E++RR+
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213

Query: 469 EL--LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
           EL  L +K RE+++  R   ++  +  E E    + ++   R ++ +L+++  + + E+ 
Sbjct: 214 ELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL-----------LNERIKNMQFSNTPD 575
           +++  L  +E ++L++E QE + +   L  E+QL             ER +  +     +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 576 SGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALE 635
                  ++  E+    Q  +EQ +   ++   +  E +    QL+  ++    QQL  E
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 636 QLYKIKRDKLKEIE-RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQE 694
           Q  + ++   +E + R+  +L ++++L  E   + +Q +E   +++ ++  E++ KR QE
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452

Query: 695 EKTQEKIQEEERKAEEKQRKDKDTLKAEEKKR 726
           E+     +EEE +  E++R+ +   + +E++R
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEER 484



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 98/451 (21%), Positives = 209/451 (46%), Gaps = 75/451 (16%)

Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
           P  ++ Q+ + Q++     E++ +        + ++R + L  Q+Q   ER+ ++ +EE 
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192

Query: 405 -------------------------------ERKQ-----------RELQEQEW-KKQLE 421
                                          E KQ           +E +E+EW K++  
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252

Query: 422 LEKRLEKQRELERQREEERRKDIER-REAAKQELERQRRLE---WERIRRQELLNQK--- 474
           L K  EK +E E QR+ E +++ E+ R+  +QEL R+R+ E    +R+RR++ L +K   
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 475 --------NREQEEIVRLNSKKKNLHLELEALNGKHQQI------SGRLQDVRLKKQTQK 520
                    REQ+E      +++   L  E    + QQ+        R Q +R +++ ++
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372

Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSL 580
            E ++  +Q      ++++ QQ  +E Q +    +  +Q L    +  +           
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432

Query: 581 LHKKSLEKEELCQRLK----EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
            H++  E+E   QRLK    E+ D L++E  ++  E +    QLK      + ++   E+
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR-----DQEEERRER 487

Query: 637 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 696
             K++ ++ +E + +R + +++++ E    R  +Q +E   ++ LR E++   +R QEE+
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LRREQEER 545

Query: 697 TQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
            ++ ++ EE K  E++R+++   + +E++R+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRD 576



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 100/427 (23%), Positives = 217/427 (50%), Gaps = 40/427 (9%)

Query: 344  LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-EKE 402
            L   Q++  ++ Q+K     E+++    ERG    + R +   E++Q   ER+ Q+  ++
Sbjct: 1518 LEEEQQLHRQQRQRKF--LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575

Query: 403  EWERKQRELQEQEWKKQLELEKRLEKQRELERQR-EEERRKDIERREAAKQELERQRRLE 461
            E +RK R L+EQ+ ++Q +  K +E +++L RQ  +++ R++ +R+    ++L ++R  E
Sbjct: 1576 ERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--E 1632

Query: 462  WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT 521
             +++ RQE  ++K  E+E  +R   +++ L  + +    + +Q+    ++ +L++Q +  
Sbjct: 1633 EQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691

Query: 522  ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
            +    ++Q   +  E K LQ+E Q  + +L     E++ L +  +  Q     +    +L
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ-ERYRKIL 1750

Query: 582  HKKSLEKEELCQRLK-----------EQLDALEKETASKLSEMDSFNNQLKELRETYNTQ 630
             ++ L  E   Q+L+           EQL    +E   +  E D    + ++LR+    Q
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810

Query: 631  QLALEQL---YKIKRDKLK---EIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKE 684
            QL  +Q    Y+ + ++L+   + +R R E  ++ + E++ A + K  +E   ++ L +E
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE---EQELWQE 1867

Query: 685  EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKK----------RETASVLVN 734
            EE+K+++ +E K +E+    ++K E++ R+  + +K++E K           + ASV V 
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGE-IKSQEGKGHGRLLEPGTHQFASVPVR 1926

Query: 735  YRALYPF 741
               LY +
Sbjct: 1927 SSPLYEY 1933



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 91/400 (22%), Positives = 201/400 (50%), Gaps = 31/400 (7%)

Query: 351  QEEEPQKKLPVTFEDKRKANYERGNME--LEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
            QEE  Q++L    +++R+   +R   E  LE+R +   E+++RE E   +++++  ER +
Sbjct: 639  QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698

Query: 409  RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ 468
              + + +W+ + E + R  K     R++E +RR    R+E  ++   R+  L+W+   R 
Sbjct: 699  SRIPKWQWQLESEADARQSKVYSRPRKQEGQRR----RQEQEEKRRRRESELQWQEEER- 753

Query: 469  ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR--LQDVRLKKQTQKTELEVL 526
                  +R+Q+E  +          E ++  G+ Q++S R  L++ R ++Q +  E +  
Sbjct: 754  -----AHRQQQEEEQRRDFTWQWQAEEKSERGR-QRLSARPPLREQR-ERQLRAEERQQR 806

Query: 527  DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSL 586
            +++   E  E +Q +++ +E + +L +L  E+Q L  R +  Q     D       ++  
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERRRS 865

Query: 587  EKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLK 646
            +++   Q+ + QL+   K     L    +   QL++ ++    ++   E+L + +R+K +
Sbjct: 866  QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE---EELQREEREKRR 922

Query: 647  EIERKR-------LELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQE 699
              E++R       L+  +++ L +E  ++ +Q +E  ++++ + +++E+Q  L EE  + 
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ-LLGEEPEKR 981

Query: 700  KIQEEERK---AEEKQRKDKDTLKAEEKKRETASVLVNYR 736
            + QE E+K    EE Q++++  L+ E +KR        YR
Sbjct: 982  RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 108/464 (23%), Positives = 220/464 (47%), Gaps = 71/464 (15%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
            Q++ +EE ++      E +R+   ER   E E+ +Q   +  + E E++ ++E+E   RK
Sbjct: 903  QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962

Query: 408  QRELQEQEWKKQL---ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
             ++LQ++E  +QL   E EKR  ++RE + + EEE ++  E  +  ++E E++RR EWER
Sbjct: 963  DKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWER 1018

Query: 465  IRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQDVRLKKQT 518
              R++  ++  +E+E+++R   +K+ L      + E E L  + +Q+ G  ++ R +++ 
Sbjct: 1019 QYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 519  QKT-----ELEVLDKQCDLEIMEIKQLQQ---------ELQEYQNKLIYLVPEKQLLNER 564
            ++      EL+  ++Q   E  E ++ Q+         ELQ+ + +L+    EK+   E 
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 565  IKNMQFSNTPDSGVSLLHKKSLEK---EELCQRLKEQLDALEKETASKLSEMDSFNNQLK 621
             +  +           L ++  EK   +EL ++ +E+ + L++E    L E      Q +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLLREEQEKRRQER 1195

Query: 622  E--LRETYNTQQLALEQLYKIK--RDKLK--------------EIERKRLELMQKKKLED 663
            E   RE    Q+   +Q Y+ +  R  LK              ++  K  E  Q ++LED
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255

Query: 664  EAAR--KAKQGKENLWKENLRKEEEEKQKRLQ------------------EEKTQEKIQE 703
               R  +++Q  ++L  E   ++ E++++R Q                  E K +++  +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315

Query: 704  EERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHD 747
            EE++   ++R++K   +  ++K      L+  R   P   +  D
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 100/465 (21%), Positives = 223/465 (47%), Gaps = 48/465 (10%)

Query: 285 IWTLADVDGDGQLKAEEFILAMHLTDMA---KAGQPLPLTLPPELVPPSFRGGKQIDSIN 341
           I  L D+D +G++   EF+L +     A     GQ   L              ++    +
Sbjct: 57  ILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLD------------EEKRARCD 104

Query: 342 GTLPSYQKMQEEEPQKKLPVTFEDK-RKANYERGNMELEKRRQA---------LMEQQQR 391
           G     Q  ++EE Q++    FE + R+   E G    +KR++            E+Q+R
Sbjct: 105 GKESLLQDRRQEEDQRR----FEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQER 160

Query: 392 EAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEE---RRKDIERRE 448
             +R  Q+  EE  R+++E QE+E ++  E + +  K  E E   +EE   RR+ +E R 
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220

Query: 449 AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKK---KNLHLELEALNGKHQQI 505
             ++E ++QRR   +R+ ++E   ++ R++E ++R   +K   +    + E    + Q  
Sbjct: 221 KGREEKQQQRRERQDRVFQEE-EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR 279

Query: 506 SGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
               Q++R ++Q ++ + + L ++  L   + ++ +++ +E + +      E++   E  
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ-----QERREQQEER 334

Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
           +  Q     +       ++  E+E   Q+L+ + +   +E   +  +      QL+  ++
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394

Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
               QQL  EQ  + ++   +E + +R + +++++ E+   +K +Q +    ++ L++E+
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---EQRLKREQ 451

Query: 686 EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT----LKAEEKKR 726
           EE++  L+ E+  E+ ++E RK + K+ ++++     LK EE++R
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 93/371 (25%), Positives = 188/371 (50%), Gaps = 33/371 (8%)

Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL---ERQ 435
           E++R     ++    +R+ ++++  +E + R+L+E+  +++ +  KR E++REL   E Q
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ--KRQEQERELAEGEEQ 154

Query: 436 REEERRKDIERREAAKQELERQRRLEWE-----RIRRQELLNQKNREQEEIVRLNSKKKN 490
            E++ R +   R+   +EL RQR+ EW+     R   ++L + K  E EE       ++ 
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQ-EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213

Query: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELE----VLDKQCDLEIMEIKQLQQELQE 546
             LEL     + +Q   R +  R+ ++ ++ E      VL K+ +    E  Q Q+ELQE
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273

Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
            + +L  L   ++L  ER +  Q          L  K+  E+ E  +  +EQ +  E++ 
Sbjct: 274 EEEQLRKL-ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLK---EIERKRLELMQKKKLED 663
             +         QL+  +E    QQL  EQ  + +  +L+   E ER+  +L ++++L  
Sbjct: 333 ERR-------EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385

Query: 664 EAARKAKQ---GKENLWKE-NLRKEEE-EKQKRLQEEKTQEKIQEEER--KAEEKQRKDK 716
           E   + +Q    ++ L +E  LR+E++  ++++L+ E+   + QEEER  +  E++R+++
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445

Query: 717 DTLKAEEKKRE 727
              + +E++R+
Sbjct: 446 RLKREQEERRD 456



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 97/395 (24%), Positives = 196/395 (49%), Gaps = 36/395 (9%)

Query: 348  QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
            +++Q+EE Q  L    E +R+   ER   E E+ +Q   E++Q   E + ++ ++E ER+
Sbjct: 1084 EELQQEEEQL-LREEPEKRRRQERERQCREEEELQQ---EEEQLLREEREKRRRQELERQ 1139

Query: 408  QRELQEQEWKKQLELEKRLEKQR--ELERQREEERRKDIERREAAKQELERQRRLEWER- 464
             RE +E + +++  L +  EK+R  ELERQ  EE     E  +  ++E E+ RR E ER 
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK-RRQERERQ 1198

Query: 465  IRRQELLNQKNREQEEIVRLNSKKKNLHLELEA------------LNGKHQQISGRLQDV 512
             R +E L ++ R+Q    R   ++ +L  + E               G+  +   +L+D 
Sbjct: 1199 YREEEELQRQKRKQR--YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256

Query: 513  RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
            +L+ +  + +L+ L     L   + +  +QE + +Q +  +   E+QL  E  K  +  +
Sbjct: 1257 QLRDRQSQQDLQHL-----LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311

Query: 573  TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQL 632
                  S   K+ L +E   +R +++ D   +E    L E +    + +E    +  ++L
Sbjct: 1312 RK----SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367

Query: 633  ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRL 692
              ++     R  L+E +R R +  ++K L++E   + ++ ++ L ++  RK  EE+Q +L
Sbjct: 1368 RHQEQ---GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ-QL 1423

Query: 693  QEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
              ++   K +EEE++   +Q +++  L+ E++ R+
Sbjct: 1424 SRQERDRKFREEEQQV-RRQERERKFLEEEQQLRQ 1457



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 106/418 (25%), Positives = 205/418 (49%), Gaps = 42/418 (10%)

Query: 345  PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE---- 400
            P  ++ QE E Q +     E+ ++   +    E EKRR+  +E+Q RE E   Q+E    
Sbjct: 1098 PEKRRRQERERQCREE---EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 401  KEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL 460
            +EE E+++R+  E++++++ EL+   +++ +L R+ +E+RR++ ER+   ++EL+RQ+R 
Sbjct: 1155 REEPEKRRRQELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211

Query: 461  EWERI--RRQELLNQKNREQEEIVRLNS-----KKKNLHLELEALNGKHQQISGRLQDVR 513
            +  R   +R +L  Q   E+E  VR N      ++     +LE    + +Q    LQ + 
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271

Query: 514  LKKQTQKTELEVLD-KQCDLEIMEIKQLQQELQ-EYQNKLIYLVPEKQLLNERIKNMQFS 571
             ++Q +  E E    +Q D    E +QL++E Q E + +      EKQLL E  +  +  
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 572  NTPDSGV----SLLHKKS---LEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELR 624
               D        LL ++    L ++E  ++ +E+    +++    L E      Q +E +
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391

Query: 625  ETYNTQQLALE----QLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKEN 680
                 QQL  +    QL + +  K +E E++     + +K  +E  +  +Q +E  + E 
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451

Query: 681  ---LRKE------EEEKQKRLQEEKTQEKIQEEERKAEEKQ---RKDKDTLKAEEKKR 726
               LR+E      EEE+  + +EE+   + + + +  EE+Q   R+++D    E++ R
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 82/381 (21%), Positives = 185/381 (48%), Gaps = 53/381 (13%)

Query: 373  RGNMELEKRRQALMEQQQREAERKAQK---------EKEEWERKQRELQEQEWKKQLELE 423
            R     +  +  L EQQ+R+ E++ ++         E+E+ ER++++  ++  +K  E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318

Query: 424  KRLEKQRELERQREEERRKDI--------ERREAAKQELERQRRLEWERIRRQELLNQKN 475
            + L ++RE E++R +E  +          ER E   +  ER R+   E +R QE   +  
Sbjct: 1319 QLLREERE-EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377

Query: 476  REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIM 535
             E++ + R   ++K L  E +    + +Q   + +D + +++ Q+   +  D+       
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR------- 1430

Query: 536  EIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRL 595
            + ++ +Q+++  + +  +L  E+QL  ER                 H+K  E+E+L Q  
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQER-----------------HRKFREEEQLLQER 1473

Query: 596  KEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL---EQLYKIKRDKLKEIERKR 652
            +EQ    ++     L E      Q ++ +  +  Q+L     E+ +  +  +L   +R+R
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRK--FREQELRSQEPERKFLEEEQQLHRQQRQR 1531

Query: 653  LELMQKKKL-EDEAARKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAE 709
              L ++++L   E  ++ +Q ++  ++  E LR+E EE+Q   QE   + +++E++ + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 710  EKQRK---DKDTLKAEEKKRE 727
            E++RK   D+  L+ +E +++
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQ 1612


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score =  127 bits (318), Expect = 1e-28
 Identities = 105/368 (28%), Positives = 185/368 (50%), Gaps = 32/368 (8%)

Query: 1162 PSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEG 1221
            P+ Q     + L  ++P E KRQ  I+EL  TE  ++  L+++ +VF +R++  G L+  
Sbjct: 767  PNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826

Query: 1222 EMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAA--------ELSH 1270
            E+  IF N ++++  +  L   +KA+R R +T      +  IG+ L          +L H
Sbjct: 827  ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS----VIDQIGEDLLTWFSGPGEEKLKH 882

Query: 1271 MQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRY 1330
              A   FCS Q     +++ +  +D+ F+ F++   S+P C+ + L   +   MQR+T+Y
Sbjct: 883  AAA--TFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940

Query: 1331 PLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG- 1389
            PLL+ +I + T E   +   +K A +   ++ + VN+ V+E EN  RLE  Q  +     
Sbjct: 941  PLLLDNIAKYT-EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL 999

Query: 1390 -LAEQLIFNSLTNC-LGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVS 1444
             L+E      L N  L  RK++H G L +K   +K  +L+  L  D L+L        V 
Sbjct: 1000 KLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVL 1059

Query: 1445 SGSEKLFSSKSNAQFKMYKTPIFLNEVLVK-LPTDPSSDEPVFHISHID---RVYTLRTD 1500
                K+ +S ++++   +   I L+ VLV+ + TD   ++ +F IS  D   ++Y L   
Sbjct: 1060 RCHSKILASTADSK-HTFSPVIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQ 1115

Query: 1501 NINERTAW 1508
             ++E+T W
Sbjct: 1116 TVSEKTVW 1123


>gi|4503593 epidermal growth factor receptor pathway substrate 15
           isoform A [Homo sapiens]
          Length = 896

 Score =  125 bits (314), Expect = 3e-28
 Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)

Query: 25  KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
           K+ RQ D    + G +    A  F  +SGLP  +L +IW L+D +  G +++QEF +A++
Sbjct: 21  KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78

Query: 85  LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
           L+     G ++ +    +   PP F    SPL+ +      +P    P+       I   
Sbjct: 79  LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138

Query: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
            S  +G      +    + P +  S LP      +  L   +  S + H        G  
Sbjct: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180

Query: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
                  A  L+           +      P +    W V    + KY + F   DK M 
Sbjct: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240

Query: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
           G++SG + R   L++ L  T LA IW+L D    G+L  ++F LA HL    + K   P 
Sbjct: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299

Query: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
           P  L PE++PPS R   Q  +I G+ P    + +    K+L     +      E+ N+E 
Sbjct: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354

Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
           + + +    +Q+    +  Q E +      ++LQ Q+ + Q  L++  E++ +LE Q +E
Sbjct: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414

Query: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
            R+K  E  +   + K EL  Q      +I   E   +  + +EE+ RL  +   L   +
Sbjct: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468

Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
           E         SG+ Q   L++  Q ++ E+   Q  +++ME+K L+
Sbjct: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503



 Score =  103 bits (257), Expect = 1e-21
 Identities = 112/461 (24%), Positives = 185/461 (40%), Gaps = 79/461 (17%)

Query: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
           TSS   +SG S       WAV    + KY   F++L   ++G+LSG + +  LL S L  
Sbjct: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162

Query: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
             L  +W L+D+D DG L  +EF +AM L   A   +P+P++LPP LVP           
Sbjct: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211

Query: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
                          P K+         KA Y+   ++ +K     +   + RE   K  
Sbjct: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256

Query: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
                    W     +   +  K Q  L   L  Q+ ++          E     +R   
Sbjct: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316

Query: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
            K  +      ++  I+  + LN       EIV L  +K N+  +L+      +Q +  +
Sbjct: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370

Query: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
           QD++ + Q + T L+              +LQ + Q+ Q  L  L  +K  L E++K ++
Sbjct: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416

Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLK-------EQLDALEKETASKLSEMDSFNNQLKE 622
                        KK  E+ +L   LK        Q+   E+E A    E+     +  E
Sbjct: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463

Query: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLED 663
           L E+  + +  LE L +  +D  +EI   +++LM+ K LE+
Sbjct: 464 LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLEN 504



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 35/91 (38%), Positives = 59/91 (64%)

Query: 16  WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
           WA+  E++ K+D  FD+L P  G+++GD+ +   L S LP  +L  +W LSD++ DG +D
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181

Query: 76  QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
           + EF++AM L+   L+ + +P+ LPP +  P
Sbjct: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)

Query: 16  WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
           W ++  E+ K+D  F    K   G+++G + R  FL++GLP+ +LA IW+L D    GK+
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277

Query: 75  DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
            + +F++A  LI  KL +G   P VL P M  P
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)

Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
           Y + +  +D   +G +    A   L +S L    L  IW LAD DG G L  +EF +A+ 
Sbjct: 19  YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78

Query: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
           L   A+ G  + L +L   + PP F        I+GT  +           +LP   + +
Sbjct: 79  LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127

Query: 367 RKANYE 372
            KA Y+
Sbjct: 128 DKAKYD 133



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 41/195 (21%), Positives = 86/195 (44%), Gaps = 34/195 (17%)

Query: 438 EERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEA 497
           +  + ++E+    K++  +QR  E      Q+L ++  RE   + +L ++K+ +   L+ 
Sbjct: 346 QREKNNVEQDLKEKEDTIKQRTSEV-----QDLQDEVQRENTNLQKLQAQKQQVQELLDE 400

Query: 498 LNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPE 557
           L+ +  Q+  +L++VR              K+C  E   I  L+ EL   ++++     E
Sbjct: 401 LDEQKAQLEEQLKEVR--------------KKCAEEAQLISSLKAELTSQESQISTYEEE 446

Query: 558 KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFN 617
                E +  +Q             +++ E EE  +  K QL+ L++       E+ S  
Sbjct: 447 LAKAREELSRLQ-------------QETAELEESVESGKAQLEPLQQHLQDSQQEISSMQ 493

Query: 618 NQLKELR--ETYNTQ 630
            +L E++  E +N+Q
Sbjct: 494 MKLMEMKDLENHNSQ 508



 Score = 38.5 bits (88), Expect = 0.055
 Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 20/125 (16%)

Query: 608 SKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR 667
           S + E+D+ NN++ +L+   N     +EQ  K K D +K+         + + L+DE  R
Sbjct: 330 SAIKELDTLNNEIVDLQREKNN----VEQDLKEKEDTIKQ------RTSEVQDLQDEVQR 379

Query: 668 KAKQGKENLWKENLRKEE-EEKQKRLQEEKTQ--EKIQEEERK-AEEKQRKDKDTLKAEE 723
           +      NL K   +K++ +E    L E+K Q  E+++E  +K AEE Q     +LKAE 
Sbjct: 380 E----NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL--ISSLKAEL 433

Query: 724 KKRET 728
             +E+
Sbjct: 434 TSQES 438



 Score = 38.1 bits (87), Expect = 0.072
 Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 9/135 (6%)

Query: 597 EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELM 656
           ++LD L  E      E ++    LKE  +T   +   ++ L    + +   +++ + +  
Sbjct: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392

Query: 657 QKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQEEKTQEKIQEEE--RKA 708
           Q ++L DE   +  Q +E L KE  +K  EE Q        L  +++Q    EEE  +  
Sbjct: 393 QVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451

Query: 709 EEKQRKDKDTLKAEE 723
           EE  R  ++T + EE
Sbjct: 452 EELSRLQQETAELEE 466


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score =  125 bits (314), Expect = 3e-28
 Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)

Query: 863  PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
            P H Q  V      A  L  + A++ + LN +  +I+ +LE+ + +W+ G      G FP
Sbjct: 427  PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486

Query: 921  KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
             +YVK+I     G   KRE              S+    G   +A + Y   +  +L+F+
Sbjct: 487  ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534

Query: 977  EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
            EGE I++ +  + EW  G +  R+GIFP N+V+P +D  + G                S 
Sbjct: 535  EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594

Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
            S S  ++   E  +   ++ A  S+ LS   G  I IL++  S W +G LQ R     +G
Sbjct: 595  SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649

Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
             FPA  V+   P+  ++  A  P  +   A+YD+   NEDELSF  G +I  +   D DW
Sbjct: 650  IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708

Query: 1138 WQGEINGVTGLFPSNYVK 1155
              GE+ G +G+FP NY++
Sbjct: 709  MSGELMGKSGIFPKNYIQ 726



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)

Query: 789  MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
            +P+ +    V P++   PP   LSAT  S++ L  N+ +S  D Q    SNL    S  K
Sbjct: 297  IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352

Query: 849  KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
               F     V P    P H                       +  + + D++ +L+Q EN
Sbjct: 353  SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391

Query: 907  WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
             +     G   G    S +KII P  E  R  P     A     + A ++V      L+ 
Sbjct: 392  NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446

Query: 965  YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
            + + +  DL  T GE + + +K D +W+ G+  ++ GIFP+NYVK   D    G+  +  
Sbjct: 447  FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506

Query: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
             S+   K         Y+    ++LS + G++I++ +     W +GE++ R      G F
Sbjct: 507  VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561

Query: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
            P + V+   P  +  T   + +   +                        A++ + A   
Sbjct: 562  PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618

Query: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
            D+LSF +G  I ++ + D DW +G +    G+FP+ +V+
Sbjct: 619  DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)

Query: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
            +P D         SGA +     A V   + A   + L+L  G+++ +L+K  + W++G 
Sbjct: 423  RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477

Query: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
                  + Q G FPA++VK++     G + +R   + H V   + +A ++Y    +DELS
Sbjct: 478  C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532

Query: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
            FS+G++I +    + +W +GE+ G TG+FP N+V+   D   S         L T  P++
Sbjct: 533  FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587

Query: 1181 RKRQ 1184
             K++
Sbjct: 588  TKKE 591



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)

Query: 738  LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
            L+ F A   D+++  SG+I+ + EK   +  W  G+ +   G FP NYV+    +P   N
Sbjct: 444  LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501

Query: 795  EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
             K    ++ +    V  S      E +   +         +      VN  W +     R
Sbjct: 502  GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557

Query: 855  T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
            T + P   V P+                        G    V +L A   +AL S+TA+ 
Sbjct: 558  TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617

Query: 887  DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
             + L+F + D I +LE+   +W  G +    G FP  +V+  P       E +++ A V 
Sbjct: 618  SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671

Query: 946  KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
            K         G +  ALY +      +L+F  G+ I   +  D +W +G +  +SGIFP 
Sbjct: 672  K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722

Query: 1005 NYVK 1008
            NY++
Sbjct: 723  NYIQ 726



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)

Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
           A + +     DE+SF+ G+II + E    E  W  G  +G  G FP N+VE +       
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576

Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
           A V   K  L      S +++    L +    ++  +   +  +L+            ++
Sbjct: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636

Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
           + W +     R  + P   V P   + +     V +  KA+AL  +  + ++ L+F   D
Sbjct: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696

Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
           IIT LE   ++W  GE+ G  G FPK+Y++ +
Sbjct: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)

Query: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
            G ++++LK+  + + + +     K    G    S +K++ P  E  R+ P     A  PV
Sbjct: 380  GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434

Query: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
                   + ++D+ A   D+L+ + G+++ ++ K D DW++G      G+FP+NYVK+  
Sbjct: 435  DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494

Query: 1159 D 1159
            D
Sbjct: 495  D 495



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
           +ALY F   N DE+SF +GDII   E    +  W+ G   G  G FP NY++
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)

Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
           ++ K+ + +E AR   +G+  ++  N   E  E            K+  + +K +     
Sbjct: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597

Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
             ++L AE  +           AL+ F A   D++SF  GD IQ+ E+   +  W  G  
Sbjct: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644

Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
           Q   G FP  +V   P+ +++  A+ PK
Sbjct: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score =  125 bits (314), Expect = 3e-28
 Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)

Query: 863  PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
            P H Q  V      A  L  + A++ + LN +  +I+ +LE+ + +W+ G      G FP
Sbjct: 463  PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522

Query: 921  KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
             +YVK+I     G   KRE              S+    G   +A + Y   +  +L+F+
Sbjct: 523  ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570

Query: 977  EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
            EGE I++ +  + EW  G +  R+GIFP N+V+P +D  + G                S 
Sbjct: 571  EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630

Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
            S S  ++   E  +   ++ A  S+ LS   G  I IL++  S W +G LQ R     +G
Sbjct: 631  SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685

Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
             FPA  V+   P+  ++  A  P  +   A+YD+   NEDELSF  G +I  +   D DW
Sbjct: 686  IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744

Query: 1138 WQGEINGVTGLFPSNYVK 1155
              GE+ G +G+FP NY++
Sbjct: 745  MSGELMGKSGIFPKNYIQ 762



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)

Query: 789  MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
            +P+ +    V P++   PP   LSAT  S++ L  N+ +S  D Q    SNL    S  K
Sbjct: 333  IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388

Query: 849  KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
               F     V P    P H                       +  + + D++ +L+Q EN
Sbjct: 389  SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427

Query: 907  WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
             +     G   G    S +KII P  E  R  P     A     + A ++V      L+ 
Sbjct: 428  NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482

Query: 965  YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
            + + +  DL  T GE + + +K D +W+ G+  ++ GIFP+NYVK   D    G+  +  
Sbjct: 483  FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542

Query: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
             S+   K         Y+    ++LS + G++I++ +     W +GE++ R      G F
Sbjct: 543  VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597

Query: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
            P + V+   P  +  T   + +   +                        A++ + A   
Sbjct: 598  PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654

Query: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
            D+LSF +G  I ++ + D DW +G +    G+FP+ +V+
Sbjct: 655  DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)

Query: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
            +P D         SGA +     A V   + A   + L+L  G+++ +L+K  + W++G 
Sbjct: 459  RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513

Query: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
                  + Q G FPA++VK++     G + +R   + H V   + +A ++Y    +DELS
Sbjct: 514  C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568

Query: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
            FS+G++I +    + +W +GE+ G TG+FP N+V+   D   S         L T  P++
Sbjct: 569  FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623

Query: 1181 RKRQ 1184
             K++
Sbjct: 624  TKKE 627



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)

Query: 738  LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
            L+ F A   D+++  SG+I+ + EK   +  W  G+ +   G FP NYV+    +P   N
Sbjct: 480  LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537

Query: 795  EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
             K    ++ +    V  S      E +   +         +      VN  W +     R
Sbjct: 538  GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593

Query: 855  T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
            T + P   V P+                        G    V +L A   +AL S+TA+ 
Sbjct: 594  TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653

Query: 887  DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
             + L+F + D I +LE+   +W  G +    G FP  +V+  P       E +++ A V 
Sbjct: 654  SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707

Query: 946  KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
            K         G +  ALY +      +L+F  G+ I   +  D +W +G +  +SGIFP 
Sbjct: 708  K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758

Query: 1005 NYVK 1008
            NY++
Sbjct: 759  NYIQ 762



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)

Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
           A + +     DE+SF+ G+II + E    E  W  G  +G  G FP N+VE +       
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612

Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
           A V   K  L      S +++    L +    ++  +   +  +L+            ++
Sbjct: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672

Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
           + W +     R  + P   V P   + +     V +  KA+AL  +  + ++ L+F   D
Sbjct: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732

Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
           IIT LE   ++W  GE+ G  G FPK+Y++ +
Sbjct: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)

Query: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
            G ++++LK+  + + + +     K    G    S +K++ P  E  R+ P     A  PV
Sbjct: 416  GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470

Query: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
                   + ++D+ A   D+L+ + G+++ ++ K D DW++G      G+FP+NYVK+  
Sbjct: 471  DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530

Query: 1159 D 1159
            D
Sbjct: 531  D 531



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
           +ALY F   N DE+SF +GDII   E    +  W+ G   G  G FP NY++
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)

Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
           ++ K+ + +E AR   +G+  ++  N   E  E            K+  + +K +     
Sbjct: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633

Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
             ++L AE  +           AL+ F A   D++SF  GD IQ+ E+   +  W  G  
Sbjct: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680

Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
           Q   G FP  +V   P+ +++  A+ PK
Sbjct: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score =  125 bits (314), Expect = 3e-28
 Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)

Query: 863  PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
            P H Q  V      A  L  + A++ + LN +  +I+ +LE+ + +W+ G      G FP
Sbjct: 486  PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545

Query: 921  KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
             +YVK+I     G   KRE              S+    G   +A + Y   +  +L+F+
Sbjct: 546  ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593

Query: 977  EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
            EGE I++ +  + EW  G +  R+GIFP N+V+P +D  + G                S 
Sbjct: 594  EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653

Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
            S S  ++   E  +   ++ A  S+ LS   G  I IL++  S W +G LQ R     +G
Sbjct: 654  SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708

Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
             FPA  V+   P+  ++  A  P  +   A+YD+   NEDELSF  G +I  +   D DW
Sbjct: 709  IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767

Query: 1138 WQGEINGVTGLFPSNYVK 1155
              GE+ G +G+FP NY++
Sbjct: 768  MSGELMGKSGIFPKNYIQ 785



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)

Query: 789  MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
            +P+ +    V P++   PP   LSAT  S++ L  N+ +S  D Q    SNL    S  K
Sbjct: 333  IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388

Query: 849  KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 901
               F     V P    P H         V   +  + + S   +    L+  + D++ +L
Sbjct: 389  SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445

Query: 902  EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 959
            +Q EN +     G   G    S +KII P  E  R  P     A     + A ++V    
Sbjct: 446  KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501

Query: 960  IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1017
              L+ + + +  DL  T GE + + +K D +W+ G+  ++ GIFP+NYVK   D    G+
Sbjct: 502  -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560

Query: 1018 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1075
              +   S+   K         Y+    ++LS + G++I++ +     W +GE++ R    
Sbjct: 561  GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616

Query: 1076 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1111
              G FP + V+   P  +  T   + +   +                        A++ +
Sbjct: 617  -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672

Query: 1112 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
             A   D+LSF +G  I ++ + D DW +G +    G+FP+ +V+
Sbjct: 673  TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)

Query: 937  PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 995
            P+  +   +K   S  + +  E I      S  PG+L+   G+  +++ Q +  +     
Sbjct: 403  PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457

Query: 996  GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1047
            G+ +G   +     + P D E   S     +  +KP  +    A V     A   + L+L
Sbjct: 458  GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516

Query: 1048 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1102
              G+++ +L+K  + W++G       + Q G FPA++VK++     G + +R   + H V
Sbjct: 517  TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571

Query: 1103 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1160
               + +A ++Y    +DELSFS+G++I +    + +W +GE+ G TG+FP N+V+   D 
Sbjct: 572  KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631

Query: 1161 DPSQQWCADLQTLDTMQPIERKRQ 1184
              S         L T  P++ K++
Sbjct: 632  PTS-----GANVLSTKVPLKTKKE 650



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)

Query: 738  LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
            L+ F A   D+++  SG+I+ + EK   +  W  G+ +   G FP NYV+    +P   N
Sbjct: 503  LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560

Query: 795  EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
             K    ++ +    V  S      E +   +         +      VN  W +     R
Sbjct: 561  GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616

Query: 855  T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
            T + P   V P+                        G    V +L A   +AL S+TA+ 
Sbjct: 617  TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676

Query: 887  DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
             + L+F + D I +LE+   +W  G +    G FP  +V+  P       E +++ A V 
Sbjct: 677  SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730

Query: 946  KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
            K         G +  ALY +      +L+F  G+ I   +  D +W +G +  +SGIFP 
Sbjct: 731  K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781

Query: 1005 NYVK 1008
            NY++
Sbjct: 782  NYIQ 785



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)

Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
           A + +     DE+SF+ G+II + E    E  W  G  +G  G FP N+VE +       
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635

Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
           A V   K  L      S +++    L +    ++  +   +  +L+            ++
Sbjct: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695

Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
           + W +     R  + P   V P   + +     V +  KA+AL  +  + ++ L+F   D
Sbjct: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755

Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
           IIT LE   ++W  GE+ G  G FPK+Y++ +
Sbjct: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
           +ALY F   N DE+SF +GDII   E    +  W+ G   G  G FP NY++
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)

Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
           ++ K+ + +E AR   +G+  ++  N   E  E            K+  + +K +     
Sbjct: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656

Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
             ++L AE  +           AL+ F A   D++SF  GD IQ+ E+   +  W  G  
Sbjct: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703

Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
           Q   G FP  +V   P+ +++  A+ PK
Sbjct: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score =  120 bits (301), Expect = 1e-26
 Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)

Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
            E  RQ  I+EL  TE  ++  L+++  +F +RM +   +   E+A +F N  ELI  +  
Sbjct: 772  EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 831

Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293
              +A+   KK   E   ++ I D++ A           Q   +FCS Q     L++ K  
Sbjct: 832  WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888

Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
            +++ F+ F+++  S P+C+ + L   ++  MQR+T+YPLL+ SI+++T    ++H  L  
Sbjct: 889  KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948

Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410
            A ++  E+   VNE V++ EN  RLE  Q  +    L   +  L     +  L  RK++H
Sbjct: 949  ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008

Query: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467
             G L ++   +K  +LH  L  D L+L     +  +     K     S+++ + +   + 
Sbjct: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1067

Query: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515
            LN VL++     ++D+  F I    +     +Y L     +++  W++ ++ A
Sbjct: 1068 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1117


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score =  120 bits (301), Expect = 1e-26
 Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)

Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
            E  RQ  I+EL  TE  ++  L+++  +F +RM +   +   E+A +F N  ELI  +  
Sbjct: 732  EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 791

Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293
              +A+   KK   E   ++ I D++ A           Q   +FCS Q     L++ K  
Sbjct: 792  WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848

Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
            +++ F+ F+++  S P+C+ + L   ++  MQR+T+YPLL+ SI+++T    ++H  L  
Sbjct: 849  KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908

Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410
            A ++  E+   VNE V++ EN  RLE  Q  +    L   +  L     +  L  RK++H
Sbjct: 909  ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968

Query: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467
             G L ++   +K  +LH  L  D L+L     +  +     K     S+++ + +   + 
Sbjct: 969  EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1027

Query: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515
            LN VL++     ++D+  F I    +     +Y L     +++  W++ ++ A
Sbjct: 1028 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1077


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score =  118 bits (295), Expect = 5e-26
 Identities = 129/550 (23%), Positives = 248/550 (45%), Gaps = 79/550 (14%)

Query: 341 NGTLPSYQKMQEEEPQKKLP-------VTFEDKRKANYERGNMELEKRRQALMEQQQREA 393
           NG + S +  QEEE ++          +  EDK +A  ER  +E E+R +   EQ ++ A
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289

Query: 394 ERKAQKEKEE----WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER--- 446
           + +A+ E EE     ER++RE +E+E  +  E EKR  ++R+  R +EEE+R   ER   
Sbjct: 290 DERARIEAEEKAAAQERERREAEERE--RMREEEKRAAEERQ--RIKEEEKRAAEERQRI 345

Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
           +E  K+  E ++R++ E  R  E   +   E+EE  ++  +K+N  LE +    +  +I 
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405

Query: 507 GRLQDVRL--------KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEK 558
           G   + ++        K Q  K +  VL KQ + +  +++  +++LQE +        ++
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF----KKE 461

Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNN 618
           ++ +E+IK                K    KEE+    K  +D  +  T  K    +   +
Sbjct: 462 EIKDEKIK----------------KDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTH 501

Query: 619 QLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKE 674
           +LK    T++          K      +    KRLE +++++ E E+      K KQ + 
Sbjct: 502 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 561

Query: 675 NLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVN 734
            L  E L+K+ EE++K L+EE+ + K +E +RK  E++ K +   + E ++ E A     
Sbjct: 562 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA----E 617

Query: 735 YRALYPFEARNHDEMSFN----SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 790
            R   P +  + D+  F      G  ++++E+      +L  S Q + G      V+   
Sbjct: 618 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA----EFLNKSVQKSSG------VKSTH 667

Query: 791 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 850
            +     +  +       +  + ++  ++P +S+ P      +N       + + W+K +
Sbjct: 668 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN-------IKSMWEKGN 720

Query: 851 AFTRTVSPGS 860
            F+   + G+
Sbjct: 721 VFSSPTAAGT 730



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 89/384 (23%), Positives = 169/384 (44%), Gaps = 29/384 (7%)

Query: 363 FEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE 421
           FE +R+   + R  M LE  R A   Q+  + E +A +E+    R++R  Q+QE +   +
Sbjct: 4   FERRRELRRQKREEMRLEAERIAY--QRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61

Query: 422 LEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
           +  ++E   +     EE +      +     E     RL     RRQ+ L +    Q+E 
Sbjct: 62  VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121

Query: 482 --------VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLE 533
                   + L S++            K ++   R +   +++    T+    +   D E
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181

Query: 534 IMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQ 593
             + +  ++E +E +      + E Q +   ++     +  ++ V  L    +  EE  Q
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQ-VEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240

Query: 594 RLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEI--ERK 651
             + +  + E     K+ E D    + +  R       L  E+  +IK ++ K+I  ER 
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERAR-------LEAEERERIKAEQDKKIADERA 293

Query: 652 RLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE-----EKQKRLQEEKTQEKIQEEER 706
           R+E  +K   ++   R+A++ +E + +E  R  EE     E++KR  EE+ + K +EE+R
Sbjct: 294 RIEAEEKAAAQERERREAEE-RERMREEEKRAAEERQRIKEEEKRAAEERQRIK-EEEKR 351

Query: 707 KAEEKQR-KDKDTLKAEEKKRETA 729
            AEE+QR K+++   AEE++R  A
Sbjct: 352 AAEERQRIKEEEKRAAEERQRARA 375



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 81/370 (21%), Positives = 171/370 (46%), Gaps = 27/370 (7%)

Query: 370 NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
           ++ER      ++R+ +  + +R A ++   ++EE  R++R    QE  +Q + E+ L   
Sbjct: 3   DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL--- 59

Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
            ++  Q E   +  +   EA       Q   + E    + L  ++ R Q+ +     ++K
Sbjct: 60  GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119

Query: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
               +    +      S R+Q+   + +T + E +   +Q   E  EI++ +   + YQ 
Sbjct: 120 --EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ---ERYEIEETETVTKSYQ- 173

Query: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSG-------VSLLHKKSLEKEELCQRLKEQLDAL 602
           K  +   E+    ++ K  +    P  G         ++ +K+ E +E    +  +   +
Sbjct: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233

Query: 603 EKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 662
             E   +  E +  ++++      +   +   ++  + +R +L+  ER+R++  Q KK+ 
Sbjct: 234 SSEEPKQEEEREQGSDEISH----HEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289

Query: 663 DEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEE-RKAEEKQR-KDK 716
           DE AR   + K    +E  R+E EE+++  +EEK     +++I+EEE R AEE+QR K++
Sbjct: 290 DERARIEAEEKAAA-QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEE 348

Query: 717 DTLKAEEKKR 726
           +   AEE++R
Sbjct: 349 EKRAAEERQR 358



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 29/199 (14%)

Query: 626 TYNTQQLALEQLYKIKRDKLKEIER-KRL-ELMQKKKLEDEAARKAKQGKENLWKENLRK 683
           T NTQ    ++   ++R   +E  R KRL E ++++K  D     A     +   +N   
Sbjct: 83  TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 142

Query: 684 EEEEKQKRLQEEKTQEKIQEEE-------------RKAEEKQRKDKDTLKAEEKKRETAS 730
           E E  +K  + E  QE+ + EE             R AEE +++DK+  + EE+K +  S
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 202

Query: 731 VLVNYRALYPFEARNHDE-----MSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNY 785
           +  N   +   E     +     MS  +G I   + K   E            G    ++
Sbjct: 203 IGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE---------REQGSDEISH 253

Query: 786 VEKMPSSENEKAVSPKKAL 804
            EKM   + E+A + +  L
Sbjct: 254 HEKMEEEDKERAEAERARL 272


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
            sapiens]
          Length = 927

 Score =  114 bits (286), Expect = 6e-25
 Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)

Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
            +++  +  P  +      TL ++   + KRQ  I EL+ TE  ++  L+++ ++F + MA
Sbjct: 403  LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 462

Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
            E  F    E+  IF +  ELI  ++  L  L  R++  G    ++ IGD+L A     + 
Sbjct: 463  ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 520

Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
                    RFCS Q      L+ K  +D  F  F+++  S PRC+ + L   +   MQR+
Sbjct: 521  SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 580

Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
            T+YPLL++SI +NT E   +   ++LA E   E+   VN+ VR+ E+  RL+  Q  +  
Sbjct: 581  TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 639

Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
              L   ++ ++       +  +KL+H G L ++   +K  E+H  L +D LLL     + 
Sbjct: 640  SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 699

Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
             +     +  +   + +  +       + +  ++ TD  +   +F      ++Y L    
Sbjct: 700  LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 759

Query: 1502 INERTAW 1508
            ++ER  W
Sbjct: 760  VSERKNW 766


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
            sapiens]
          Length = 879

 Score =  114 bits (286), Expect = 6e-25
 Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)

Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
            +++  +  P  +      TL ++   + KRQ  I EL+ TE  ++  L+++ ++F + MA
Sbjct: 355  LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414

Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
            E  F    E+  IF +  ELI  ++  L  L  R++  G    ++ IGD+L A     + 
Sbjct: 415  ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472

Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
                    RFCS Q      L+ K  +D  F  F+++  S PRC+ + L   +   MQR+
Sbjct: 473  SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532

Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
            T+YPLL++SI +NT E   +   ++LA E   E+   VN+ VR+ E+  RL+  Q  +  
Sbjct: 533  TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591

Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
              L   ++ ++       +  +KL+H G L ++   +K  E+H  L +D LLL     + 
Sbjct: 592  SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651

Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
             +     +  +   + +  +       + +  ++ TD  +   +F      ++Y L    
Sbjct: 652  LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711

Query: 1502 INERTAW 1508
            ++ER  W
Sbjct: 712  VSERKNW 718


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
            sapiens]
          Length = 912

 Score =  114 bits (286), Expect = 6e-25
 Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)

Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
            +++  +  P  +      TL ++   + KRQ  I EL+ TE  ++  L+++ ++F + MA
Sbjct: 388  LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 447

Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
            E  F    E+  IF +  ELI  ++  L  L  R++  G    ++ IGD+L A     + 
Sbjct: 448  ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 505

Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
                    RFCS Q      L+ K  +D  F  F+++  S PRC+ + L   +   MQR+
Sbjct: 506  SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 565

Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
            T+YPLL++SI +NT E   +   ++LA E   E+   VN+ VR+ E+  RL+  Q  +  
Sbjct: 566  TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 624

Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
              L   ++ ++       +  +KL+H G L ++   +K  E+H  L +D LLL     + 
Sbjct: 625  SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 684

Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
             +     +  +   + +  +       + +  ++ TD  +   +F      ++Y L    
Sbjct: 685  LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 744

Query: 1502 INERTAW 1508
            ++ER  W
Sbjct: 745  VSERKNW 751


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
            exchange factor [Homo sapiens]
          Length = 871

 Score =  112 bits (280), Expect = 3e-24
 Identities = 75/272 (27%), Positives = 137/272 (50%), Gaps = 21/272 (7%)

Query: 1175 TMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELI 1234
            T+   ERKRQ  I E+I +E  Y+  L++++ +F+     S  +T+ E   +F N  ++ 
Sbjct: 432  TVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVC 491

Query: 1235 MSNTKLLKALRVRKKTGGEKMPVQMIGDILAAEL-SHMQAYIRFCSCQLNGAALLQQKTD 1293
             ++ K    L  R +     + +  I DI+     S    Y+++C+ ++     LQ+   
Sbjct: 492  EASKKFFIELEARHQNN---IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLA 548

Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
             +  FKE L ++ S   C+ +P+ SFL+ PMQR+TR PLL+ +I + TP+    +   K 
Sbjct: 549  TNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKR 608

Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
            AL+   +L    NEG R+ E ++ +  I + ++ +     L+ +S       R L+  G+
Sbjct: 609  ALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS-------RWLVKRGE 661

Query: 1414 L----------YKTKSNKELHGFLFNDFLLLT 1435
            L           +  S ++++ FLFND L++T
Sbjct: 662  LTAYVEDTVLFSRRTSKQQVYFFLFNDVLIIT 693



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 3/70 (4%)

Query: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
            S+ K  A        ++  ++ A   ++LSL    ++LI ++ + GW++GE   R +  +
Sbjct: 780  SSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE---RLRDGE 836

Query: 1077 KGWFPASHVK 1086
            +GWFP    K
Sbjct: 837  RGWFPMECAK 846



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 3/50 (6%)

Query: 881 SWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSYVKII 927
           S+TAK+ + L+    D++ + ++  + W+ GE    G RGWFP    K I
Sbjct: 799 SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEI 848



 Score = 31.2 bits (69), Expect = 8.8
 Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 2/79 (2%)

Query: 1082 ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1141
            A  +  LG SS +       + QV  +  + A   DELS     ++ +  +    W++GE
Sbjct: 771  ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE 830

Query: 1142 --INGVTGLFPSNYVKMTT 1158
               +G  G FP    K  T
Sbjct: 831  RLRDGERGWFPMECAKEIT 849


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  109 bits (272), Expect = 3e-23
 Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 28/343 (8%)

Query: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD----SDP 1162
            A++D+   ++ EL F  G +I V+   + DWW G        FP+++V++  +    S+ 
Sbjct: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213

Query: 1163 SQQWCADLQTLDTMQPIERK-------RQGYIHELIQTEERYMADLQLVVEVFQKRMAE- 1214
            S    ++ Q  +  Q   R        R   I E++ TE  Y+  L+ + E + ++  + 
Sbjct: 214  SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273

Query: 1215 SGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAY 1274
            +G  T  ++A IF N +++     K LK L   K+   E+  +  IG            Y
Sbjct: 274  TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQEGFAIY 331

Query: 1275 IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLI 1334
              +C+    GA L      +   ++ F +      +   + +  FLL P+Q+I +YPL +
Sbjct: 332  SEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQL 390

Query: 1335 RSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQ 1393
              +L+ T + H D+S++K A E  + +   +NE  R+ E+ D++  W  + V  EGL   
Sbjct: 391  AELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGL--D 448

Query: 1394 LIFNSLTNCLGPRKLLHSGKLYK-TKSNKELHG--FLFNDFLL 1433
            ++  S        +L+HSG+L K TK  K      FLF+  L+
Sbjct: 449  ILDRS-------SELIHSGELTKITKQGKSQQRTFFLFDHQLV 484



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 14/121 (11%)

Query: 811 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPG----SVSPIHG 866
           + A++ SS+     +P+++ D  N S  + +     Q   A  R + PG    +++ +  
Sbjct: 92  MRASNVSSD--GGTEPSALVD-DNGSEEDFSYEDLCQ---ASPRYLQPGGEQLAINELIS 145

Query: 867 QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVK 925
            G VV    A+AL       D  L F   D+I VLE   ++WW+G       WFP S+V+
Sbjct: 146 DGNVV---CAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202

Query: 926 I 926
           +
Sbjct: 203 L 203



 Score = 36.2 bits (82), Expect = 0.27
 Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)

Query: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVKPK-DQESFGSA 1018
            AL+ + +++  +L F  G+ I V +    +WW G   D+   FP+++V+ + +QE     
Sbjct: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213

Query: 1019 SKSGASNKKPEIA 1031
            S S  S ++ E A
Sbjct: 214  SSSTPSEEQDEEA 226



 Score = 34.7 bits (78), Expect = 0.80
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 793
           AL+     +  E+ F +GD+IQV E       W +G  +    WFP ++V    + E
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLE--ASNKDWWWGRSEDKEAWFPASFVRLRVNQE 208


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score =  109 bits (272), Expect = 3e-23
 Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 26/291 (8%)

Query: 1169 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1228
            +L  LD +   ERKRQ  + E++ +E  Y   L ++VE F +       +T+ E   +F 
Sbjct: 271  ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330

Query: 1229 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAAL 1287
            N  +++ ++ +  + L  R K    ++ V+ I DIL      H   YI +CS ++     
Sbjct: 331  NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387

Query: 1288 LQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHAD 1347
            LQ+    +  F+E L+++   P C G+P+ SFL+ PMQR+TR PLL+ ++   T      
Sbjct: 388  LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447

Query: 1348 HSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRK 1407
            + +   AL+   +L  Q NEG    E  +++  +   +    +       SL      R 
Sbjct: 448  YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV------KSLPLISASRW 501

Query: 1408 LLHSGKLY---------KTKSNKELHGFLFNDFLLLT-------YMVKQFA 1442
            LL  G+L+         K  S    + FLFND L++T       YMV+ +A
Sbjct: 502  LLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYA 552



 Score = 38.5 bits (88), Expect = 0.055
 Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%)

Query: 884 AKKDNHLNFSKHDIITVLEQQENWWFGE--VHGGRGWFPKSYVKII 927
           AK+ + +   + D++ VL+Q++ W +GE    G  GWFP+ + + I
Sbjct: 642 AKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFI 687


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  107 bits (267), Expect = 1e-22
 Identities = 97/392 (24%), Positives = 203/392 (51%), Gaps = 30/392 (7%)

Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE 410
           +EE+ +++  + +E + K   +   M  ++ +    E+   E E K  +E EE   +Q +
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEK 405

Query: 411 LQEQEWKKQ-----LELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWER 464
           ++EQE K+Q      E EKR E++ ++ RQ E+ R ++ + RE  K+   ++ ++ E E+
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465

Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT--- 521
           IR +E    K +EQEE+ R   K   +H + E    K +      Q+ +++KQ +K    
Sbjct: 466 IREEE----KRQEQEEMWRQEEK---IHEQEEIWRQKEKMHE---QEEKIRKQEEKVWRQ 515

Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
           E ++ +++  +   E K  +QE +  + + ++   EK    E+I   +     +  +   
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575

Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL-EQLYKI 640
            +K  E+EE   R +E++   E++   +  +M     +++E  E    Q+  + EQ  KI
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635

Query: 641 K-RDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQE 699
           + ++++ + + +++   ++K  E E   K ++ +E +W++  +  E+EK+ R QEEK +E
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQE--EKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693

Query: 700 K---IQEEERK---AEEKQRKDKDTLKAEEKK 725
           +   +QE+E K    EEK  + ++ ++ +E+K
Sbjct: 694 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 725



 Score =  106 bits (265), Expect = 2e-22
 Identities = 101/436 (23%), Positives = 216/436 (49%), Gaps = 36/436 (8%)

Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
           +++E+  + +++ ++ +  +   L LP + L   +   GK++ S++  L +  +++E E 
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 290

Query: 356 QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE 415
             +L    E+K     E+     EK       Q+Q E  R+ +++  E E K R  +E  
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKI------QEQEEKIREQEEKIREQEEKMRRQEEMM 344

Query: 416 WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
           W+K    E+++ +Q E+  ++EE+ R+  E     ++++ RQ  + WE+  +   L +K 
Sbjct: 345 WEK----EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400

Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK-TELEVLDKQCDLEI 534
            EQE+I     K++      E    + Q+     Q+ ++++Q +K  E E    + + +I
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460

Query: 535 MEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQR 594
            E +++++E +  + + ++   EK    E I   +        +    +K  ++EE   R
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK------EKMHEQEEKIRKQEEKVWR 514

Query: 595 LKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLE 654
            +E++   E++   +  +M     +++E  E +  ++   EQ      +K+ E E KR E
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ------EKIWE-EEKRQE 567

Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE---KTQEKIQEEERKAEEK 711
              K   ++E   K ++ +E +W++  +  E+E++++ QEE   K +EKI+E+E K +E+
Sbjct: 568 QEDKMWRQEE---KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624

Query: 712 QRKDKDTLKAEEKKRE 727
           + K ++    EEK RE
Sbjct: 625 EEKIRE---QEEKIRE 637



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 108/487 (22%), Positives = 219/487 (44%), Gaps = 85/487 (17%)

Query: 354 EPQKKLPVTFEDKRKANY-------ERGNMELEKRRQALMEQQQREAERKAQKEKE--EW 404
           E ++ L      K+KA+        ER  + LE  R  + +++ +E   K Q++ +  E 
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235

Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQ-------------------REEERRKDIE 445
           E+ + +L  +E K++LE  K L  Q++L+ +                    E E    + 
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295

Query: 446 RREAAKQELERQRRLEW-ERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL-----EALN 499
           +++  K   + ++  EW E+I+ QE   +K REQEE +R   +K     E+     E + 
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352

Query: 500 GKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE--YQNKLIYLVPE 557
            + + +  + + +R +++    + E + +Q ++ + E ++  +EL+E  ++ + I    E
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKIRELEEKMHEQEKIREQEE 411

Query: 558 KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELC-----------QRLKEQLDALEKET 606
           K+   E+I+  +     ++ +    +K  E+EE             +++ EQ    E+E 
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471

Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR---------DKLKEIERKRLELMQ 657
             +  EM     ++ E  E +  ++   EQ  KI++         +K++E E K  E  +
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531

Query: 658 KKKLEDEAARKAKQ---------GKENLWKENLRKEEEEKQKRLQEE---------KTQE 699
           K   ++E  R+ ++          +E +W+E  R+E+E+K  R +E+         + +E
Sbjct: 532 KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591

Query: 700 KIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQV 759
           KI+E+E K +E++ K     K EEK RE    +         + R  +E      ++ Q 
Sbjct: 592 KIREQEEKRQEQEEK---MWKQEEKIREQEEKIQEQEE----KIREQEEKIREQEEMTQE 644

Query: 760 DEKTVGE 766
            E+ +GE
Sbjct: 645 QEEKMGE 651



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 82/388 (21%), Positives = 188/388 (48%), Gaps = 41/388 (10%)

Query: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAE 394
           ++I  +   +   +K++E+E +++      ++ K   +   M  ++ +    E++ RE E
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450

Query: 395 RKAQKEKE---EWERKQRELQEQEWKKQLELEKRLEKQRELERQREE--ERRKDIERREA 449
           +K  +++E   E E+ + E + QE ++    E+++ +Q E+ RQ+E+  E+ + I ++E 
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510

Query: 450 AKQELERQRRLEWERIRRQE----LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQI 505
                E + R + E+IR QE       +K REQEE+ R   K        E    + Q+ 
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570

Query: 506 SGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
               Q+ ++++Q +K   +           +I++ +++ QE + K+      KQ   E+I
Sbjct: 571 KMWRQEEKIREQEEKVWRQE---------EKIREQEEKRQEQEEKMW-----KQ--EEKI 614

Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
           +  +             +K  E+EE  +  +E++   E+ T  +  +M     ++ E  E
Sbjct: 615 REQE-------------EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661

Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
               Q+  + +  +  R++ K+I  +  ++ +++++  E   K  + +E + ++  + +E
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 721

Query: 686 EEKQKRLQEEKTQE---KIQEEERKAEE 710
           +E++ R QEEK  E   +++++E K +E
Sbjct: 722 QEEKMRRQEEKMWEQEVRLRQQEEKMQE 749



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 76/327 (23%), Positives = 145/327 (44%), Gaps = 47/327 (14%)

Query: 437 EEERRKDIERREAAKQELERQ-RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
           E+E++   + +EA ++ELE Q   +     ++ EL       Q  + +L  + ++L   L
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167

Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEI-------KQLQQELQEYQ 548
                   ++   L  V  +K+     +E L K+ D   +E+       ++L+++  + Q
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227

Query: 549 NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELC---QRLKEQLDALEKE 605
            KL  +  EK  +   +K +              K+ LE+ +L    Q+L+ + D L KE
Sbjct: 228 EKLQLVESEKSEIQLNVKEL--------------KRKLERAKLLLPQQQLQAEADHLGKE 273

Query: 606 TAS---KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 662
             S   KL      N     L +    +    E+  +   +K++E E K  E  +K + +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333

Query: 663 DEAAR-----------KAKQGKENLW--KENLRKEEE-----EKQKRLQEEKTQEKIQEE 704
           +E  R           K ++ +E +W  +E +R++EE     E++ R QEE   EK +E+
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEK 392

Query: 705 ERKAEEKQRKDKDTLKAEEKKRETASV 731
            R+ EEK  + +   + EEK++E   +
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKI 419


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  107 bits (267), Expect = 1e-22
 Identities = 92/406 (22%), Positives = 202/406 (49%), Gaps = 41/406 (10%)

Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WER 406
           +KM+EE+  ++      D+ +   E   +   +++    E+  RE E K QK++E  WE+
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE--- 461
           +++E Q+Q   +Q E     EK +E E +   +EE+ +D E     ++++ RQ ++    
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543

Query: 462 ---WERIRRQELLNQKNREQEEIVRLNSKKKNLHL-ELEALNGKHQQISGRLQDVRLKKQ 517
              WE+  +     QK  +QEE +   ++++     + E    + +++  R + +R +++
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603

Query: 518 TQKTELEVLDKQCD-LEIMEIKQLQQE--LQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
             + + E + +Q + ++  E K  +QE  +QE + K+     E+++  +  K  +    P
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM--WEQEEKMWEQEEKMWEQQRLP 661

Query: 575 DSGVSLLHKKSLEKEELCQRLKEQL---DALEKETAS---------KLSEMDSFNNQLKE 622
           +    L   + ++++E  Q  +E++   + +EK+T           K+ E +S   + K+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721

Query: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLR 682
           +RE         E++ + + +K++E E K  E  ++   ++E   K  + +E +W++   
Sbjct: 722 MREE--------EEMMREQEEKMQEQEEKMQEQEEEMWEQEE---KMWEQEEKMWEQQRL 770

Query: 683 KEEEEKQKRLQEEKTQEKIQEEERK---AEEKQRKDKDTLKAEEKK 725
            E++EK    ++ + QEKI E+E K    EEK R  ++ ++ +E+K
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK 816



 Score =  105 bits (263), Expect = 3e-22
 Identities = 99/448 (22%), Positives = 222/448 (49%), Gaps = 40/448 (8%)

Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE-EWERK 407
           KM+E+E +    +  ++KR    E+   E EK  +   E +++E + + Q+EK  E E K
Sbjct: 308 KMREQEEK----MWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363

Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE--WERI 465
            RE +E+ W+++  L ++ ++ RE E++  ++  +  E+ E  +++ ER R  E  WE++
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423

Query: 466 ------RRQELLNQKNREQEEIV----RLNSKKKNLHLELEALNGKHQQISGRLQDV--R 513
                 ++ +   +K R+QEE +    R+  ++K +  E E +  + +++  + +++  +
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 514 LKKQTQKTEL----EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
            +K+ Q+  L    E L +Q  ++  E K  +QE +    + ++   +K    E+++  +
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543

Query: 570 FSN-TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYN 628
                 +  +    +K  ++EE  ++  ++ +    +   K+ E +    + K++RE   
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603

Query: 629 TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA----RKAKQGKENLWKENLRKE 684
             +   E++ + + +K++E E K  E  +K + ++E       K  + +E +W++    E
Sbjct: 604 MMREQEEKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662

Query: 685 EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAE------EKKRETASVLVNYRAL 738
           ++EK    ++ + QEK+QE+E K  E+++ +K T + E      EK RE  S+    + +
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722

Query: 739 YPFEARNHDEMSFNSGDIIQVDEKTVGE 766
                R  +EM     + +Q  E+ + E
Sbjct: 723 -----REEEEMMREQEEKMQEQEEKMQE 745



 Score =  102 bits (255), Expect = 2e-21
 Identities = 96/410 (23%), Positives = 206/410 (50%), Gaps = 54/410 (13%)

Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
           K +  E Q+KLP+   +K +   N +    +LE+ +  L + Q    + +  +++EE   
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283

Query: 407 KQRELQEQE---WKKQLEL-----------------EKRLEKQRELERQREEERRKDIER 446
           +++++++QE   W+++  L                 EKRL +Q +  R++E+E R+  E 
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL 343

Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
           RE  +Q  E++ ++ WE+  +     +K   QEE  RL  ++K +  + + +  + +++ 
Sbjct: 344 REQEEQMQEQEEKM-WEQEEKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEERMW 400

Query: 507 GRLQDVRLK-KQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
              QD RL+ K+ +  E E + +Q + ++ E K++Q++ ++ +++      EK    ERI
Sbjct: 401 E--QDERLREKEERMREQEKMWEQVE-KMREEKKMQEQEKKTRDQ-----EEKMQEEERI 452

Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
           +  +             KK  E+EE  +  +E++   ++E   +  E +    +L E +E
Sbjct: 453 RERE-------------KKMREEEETMREQEEKMQK-QEENMWEQEEKEWQQQRLPEQKE 498

Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
               Q+   EQ  KI   + K  +++ +   +KK    E   K ++ ++ +W++  +  +
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE---KMREQEDQMWEQEEKMRD 555

Query: 686 EEKQKRLQEEKTQEKIQEEERKA---EEKQRKDKDTLKAEEKKRETASVL 732
           +E++   QEE+ ++K QE+E+K    EEK R+++   + E+K RE   ++
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605



 Score =  102 bits (254), Expect = 3e-21
 Identities = 99/443 (22%), Positives = 204/443 (46%), Gaps = 43/443 (9%)

Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
           TL      QEEE +       E ++K   +   M  ++ R    E + RE E K  ++++
Sbjct: 269 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321

Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
               +++EL+EQE  K+L  +K L +Q E  +++EE+  +  E+    ++++ RQ    W
Sbjct: 322 RLREQEKELREQE--KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379

Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLHLE---LEALNGKHQQISGRLQDVRL 514
           E+ ++     QK R+QEE +     RL  K++ +  +    E +    ++   + Q+ + 
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439

Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
           + Q +K + E   ++ + ++ E ++  +E +E   K      E+ +  +  K  Q    P
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-----QEENMWEQEEKEWQQQRLP 494

Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDAL--------EKETASKLSEMDSFNNQLKELRET 626
           +    L  ++ ++++E  +++ EQ + +        +++   +  +M    +Q+ E  E 
Sbjct: 495 EQKEKLWEQEKMQEQE--EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552

Query: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE 686
              Q+  +    +    K +E E+K  +  +K + E+    + K+ +E   +E + +E+E
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE---EEEMMREQE 609

Query: 687 EKQKRLQEEKTQ---EKIQEEERKAEEKQRK----DKDTLKAEEKKRETASVLVNYRALY 739
           EK +  QEEK Q   EK+ E+E K +E++ K    ++   + EEK  E   +      L+
Sbjct: 610 EKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668

Query: 740 PFEARNHDEMSFNSGDIIQVDEK 762
             E     E      + I   EK
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEK 691



 Score =  100 bits (248), Expect = 2e-20
 Identities = 92/395 (23%), Positives = 198/395 (50%), Gaps = 25/395 (6%)

Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWE----- 405
           QEE+  ++    +E +++   +   M  ++ R    +++ RE E + +++++ WE     
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426

Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELERQR-----EEERRKDIERREAAKQELERQRRL 460
           R+++++QEQE K + + EK  E++R  ER++     EE  R+  E+ +  ++ +  Q   
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486

Query: 461 EWERIR----RQELLNQ-KNREQEEIVRLNSKKKNLHLELEALNGKH-QQISGRLQDVRL 514
           EW++ R    +++L  Q K +EQEE +    +K     E+     K  +Q   R Q+ ++
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546

Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
            +Q +K   +        E ME K  +QE + +  +    + E++ + ER K M+     
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE--EKMREEERMREREKKMR---EE 601

Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL 634
           +  +    +K  E+EE  Q  +E++   E++   +  +M     ++ E  E    QQ   
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661

Query: 635 EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE---EKQKR 691
           EQ  K+   +  + + K  E  +K   +++  +K ++ ++  W +   +EEE   E++K+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721

Query: 692 LQEEKTQEKIQEEE-RKAEEKQRKDKDTLKAEEKK 725
           ++EE+   + QEE+ ++ EEK ++ ++ +  +E+K
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 90/408 (22%), Positives = 209/408 (51%), Gaps = 34/408 (8%)

Query: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW-E 405
           +++ ++E  Q++LP   E K K  +E+  M+ ++ +    E++ R+ E    +EK+ W +
Sbjct: 481 WEQEEKEWQQQRLP---EQKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536

Query: 406 RKQRELQEQEWKKQLEL----EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
            K RE ++Q W+++ ++    +K  +++  +E++ +E+ +K  ++ E  ++E ER R  E
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-ERMRERE 595

Query: 462 WERIRRQELLN-QKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK 520
            +    +E++  Q+ + QE+  ++  +++ +  + E +  + +++  + + +  +++   
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655

Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM--QFSNTPDSGV 578
            +  + +++  L   E  Q Q+++QE + K+      ++   E+ K    Q     +  +
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715

Query: 579 SLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLY 638
               KK  E+EE+ +  +E++   E++   +  EM     ++ E  E    QQ   EQ  
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775

Query: 639 KI-------KRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKENLW--KENLRKEE 685
           K+       +++K+ E E K  +  +K + ++E  R    K +  +E +W  +E +  +E
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE 835

Query: 686 E-----EKQKRLQEEKTQEKIQEEE---RKAEEKQRKDKDTLKAEEKK 725
           E     E++   QEEK +EK+Q +E   R+ EEK R  ++ ++ +E+K
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883



 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 97/369 (26%), Positives = 188/369 (50%), Gaps = 56/369 (15%)

Query: 372 ERGNMELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
           ER  + LE  R  +  ++  ++ AE + +    E E+ + +L  +E K++LE  K L  Q
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQ 264

Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEW---ERIRRQELLNQKNREQEEIVRLNS 486
            +    +EE  R++ E RE  K+ + +Q    W   ER+R QE    K REQEE +    
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQE---GKMREQEEKMWRQE 320

Query: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
           K+         L  + +++  + +++R +K+ ++ E ++ +++  +   E K  +QE + 
Sbjct: 321 KR---------LREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371

Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
           ++ +      EKQ+  +                   +K  ++EE   R+ EQ + L +E 
Sbjct: 372 WRQEERLWEQEKQMREQ------------------EQKMRDQEE---RMWEQDERL-REK 409

Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 666
             ++ E +    Q++++RE    Q+   E+  + + +K++E ER R E  +K + E+E  
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQE--QEKKTRDQEEKMQEEERIR-EREKKMREEEETM 466

Query: 667 R----KAKQGKENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEERKAEEKQRK--DK 716
           R    K ++ +EN+W++   +E+E +Q+RL E+K     QEK+QE+E K  E++ K  D+
Sbjct: 467 REQEEKMQKQEENMWEQ---EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523

Query: 717 DTLKAEEKK 725
           + +  +EKK
Sbjct: 524 EEMWGQEKK 532



 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 75/314 (23%), Positives = 152/314 (48%), Gaps = 32/314 (10%)

Query: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486
           E QR L       ++ D    E  K+       L    I  +EL  +    QE++    S
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239

Query: 487 KKKNLHLELEALNGKHQQISGRLQDVR---LKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
           +K  + L ++ L  K ++    L  V+   L+++  + E E+ +++  +   E K  +QE
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299

Query: 544 --LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
             L+E + K+     +     +R++  +              K L ++E  + L+EQ + 
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQE--------------KELREQE--KELREQKEL 343

Query: 602 LEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 661
            E+E   +  E +    Q +++RE         E+L++ +  +++E E+K  +  ++   
Sbjct: 344 REQEEQMQEQE-EKMWEQEEKMREQEEKMWRQEERLWE-QEKQMREQEQKMRDQEERMWE 401

Query: 662 EDEAARKAKQ---GKENLWKENLRKEEEEKQKRLQEEKT---QEKIQEEE--RKAEEKQR 713
           +DE  R+ ++    +E +W E + K  EEK+ + QE+KT   +EK+QEEE  R+ E+K R
Sbjct: 402 QDERLREKEERMREQEKMW-EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460

Query: 714 KDKDTLKAEEKKRE 727
           ++++T++ +E+K +
Sbjct: 461 EEEETMREQEEKMQ 474



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 83/384 (21%), Positives = 169/384 (44%), Gaps = 95/384 (24%)

Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
           +KM+EEE   +     ++++    E    E E++     E+ Q + E+  ++E++ WE++
Sbjct: 596 KKMREEEEMMRE----QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651

Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW--ERI 465
           ++  ++Q   +Q E     EK +E E+ +E+E +  I  +E  +++ + Q +  W  E++
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK--IWEQEKMEKKTQEQEKKTWDQEKM 709

Query: 466 RRQELLNQ---KNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
           R +E + +   K RE+EE++R   +K                    +Q+   K Q Q+ E
Sbjct: 710 REEESMREREKKMREEEEMMREQEEK--------------------MQEQEEKMQEQEEE 749

Query: 523 L-EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
           + E  +K  + E  E    QQ L E + KL                              
Sbjct: 750 MWEQEEKMWEQE--EKMWEQQRLPEQKEKL----------------------------WE 779

Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIK 641
           H+K  E+E++ ++ ++  D  EK                              E+  + +
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQ--------------------------EEKMRGQ 813

Query: 642 RDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKI 701
            +K++  E K     +K   ++E   K    +E +W +   +E+ E++ + QEEK +E+ 
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEE---KMWGQEEKMWGQ---EEKMEEKMQGQEEKMREQ- 866

Query: 702 QEEERKAEEKQRKDKDTLKAEEKK 725
           +E+ R  EEK R+ ++ ++ +E+K
Sbjct: 867 EEKMRGQEEKMREQEEKMRGQEEK 890



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 58/233 (24%), Positives = 124/233 (53%), Gaps = 32/233 (13%)

Query: 347 YQKMQEEE----------PQKKLPVTFEDKRKANYERGNMELE---KRRQALM---EQQQ 390
           ++KMQE+E           Q+K+    +++ K  +++  M  E   + R+  M   E+  
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729

Query: 391 REAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQRE--------EERRK 442
           RE E K Q+++E+ + ++ E+ EQE +K  E E+++ +Q+ L  Q+E        +E+ K
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQE-EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788

Query: 443 DIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH 502
             E+ E  + + E+ R  E E++R QE   +K R QEE  ++  +++ +  + E + G+ 
Sbjct: 789 IWEQEEKMRDQEEKMRGQE-EKMRGQE---EKMRGQEE--KMWGQEEKMWGQEEKMWGQE 842

Query: 503 QQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLV 555
           +++ G+ + +  K Q Q+ ++   +++   +  ++++ Q+E    Q + IY V
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKMRGQEEKIYCV 894


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
            sapiens]
          Length = 532

 Score =  107 bits (267), Expect = 1e-22
 Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
            E KRQ  I EL Q EE  + DL+L  + +   M +   +TE E+  IF     LI  + +
Sbjct: 126  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185

Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
            LL  LR  +K  G     + +G IL   L  + +Y  +CS Q+   ALL  K  +D   +
Sbjct: 186  LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 241

Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
            +FL++    P  + + L +FL  P  R+ +YPLL+R IL +TP  + D   L+ A+   +
Sbjct: 242  DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 301

Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
             + +++N    E E     +RL +++     EG  + LI +S       R L   G+L K
Sbjct: 302  GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 348

Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
                 +LH FLF + L++T  V      + +E+L        +++Y+ PI + ++L++
Sbjct: 349  NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 393


>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
            sapiens]
          Length = 558

 Score =  107 bits (267), Expect = 1e-22
 Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
            E KRQ  I EL Q EE  + DL+L  + +   M +   +TE E+  IF     LI  + +
Sbjct: 152  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211

Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
            LL  LR  +K  G     + +G IL   L  + +Y  +CS Q+   ALL  K  +D   +
Sbjct: 212  LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 267

Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
            +FL++    P  + + L +FL  P  R+ +YPLL+R IL +TP  + D   L+ A+   +
Sbjct: 268  DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 327

Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
             + +++N    E E     +RL +++     EG  + LI +S       R L   G+L K
Sbjct: 328  GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 374

Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
                 +LH FLF + L++T  V      + +E+L        +++Y+ PI + ++L++
Sbjct: 375  NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 419


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
            sapiens]
          Length = 526

 Score =  107 bits (267), Expect = 1e-22
 Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
            E KRQ  I EL Q EE  + DL+L  + +   M +   +TE E+  IF     LI  + +
Sbjct: 120  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 179

Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
            LL  LR  +K  G     + +G IL   L  + +Y  +CS Q+   ALL  K  +D   +
Sbjct: 180  LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 235

Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
            +FL++    P  + + L +FL  P  R+ +YPLL+R IL +TP  + D   L+ A+   +
Sbjct: 236  DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 295

Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
             + +++N    E E     +RL +++     EG  + LI +S       R L   G+L K
Sbjct: 296  GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 342

Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
                 +LH FLF + L++T  V      + +E+L        +++Y+ PI + ++L++
Sbjct: 343  NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 387


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  106 bits (264), Expect = 2e-22
 Identities = 96/411 (23%), Positives = 203/411 (49%), Gaps = 38/411 (9%)

Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
           TL      QEEE +       E ++K   +   M  ++ R    E + RE E K +++++
Sbjct: 231 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK 283

Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
               +++EL+EQE  K+L  +K+L +Q E  +++EE+  +  E+    ++++ RQ    W
Sbjct: 284 RLREQEKELREQE--KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341

Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLH-----LELEALNGKHQQISGRLQDV 512
           E+ ++     QK R+QEE +     RL  K++ +       E E    + ++I  R + +
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401

Query: 513 RLKKQTQKTELEVLDKQCD-LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
           R +++T + + E + KQ + +   E K+ QQ+    Q + ++   + Q   E+I   +  
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461

Query: 572 NTPDSGVSLLHKKSLEKEELCQR------LKEQLDALEKETASKLSEMDSFNNQLKELRE 625
                 +    KK   +E++ ++       +E++   E++   +   M   + +L+E  E
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521

Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKENLWKENL 681
               Q+   +Q  K++ +K  + + K+    ++K  E+E  R    K ++ +E + ++  
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581

Query: 682 RKEEEEKQKRLQEEK---TQEKIQEEERKAEEKQRK-----DKDTLKAEEK 724
           + +E+E++ R QEEK    +EK+QE+E K  E++ K     ++D ++ +E+
Sbjct: 582 KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE 632



 Score =  106 bits (264), Expect = 2e-22
 Identities = 97/411 (23%), Positives = 200/411 (48%), Gaps = 51/411 (12%)

Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ------------ 398
           QEE+ Q++    +E + K   +   M  ++ R    E+Q RE E+K +            
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367

Query: 399 -KEKEEWERKQRELQEQEWKKQ-----LELEKRLEKQRELERQREEERRK------DIER 446
            +EKEE  R+Q ++ EQE K Q      E EK++ ++ E  R++EE+ +K      + E 
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 427

Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
           +E  +Q L  Q+   WE+ + QE   +K  EQEE +R          + E + G+ +++ 
Sbjct: 428 KEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIR----------DQEEMWGQEKKMW 476

Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
            + +    + Q  + E ++ D++  +   E +  +Q+ +  + K   +  +K++  +  K
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD-ERLREKEERMREQKKMWQQEEK 535

Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRET 626
             +   T +       ++   +EE  +R++E+   + +E      + +    Q +++RE 
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREE--ERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593

Query: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLED------EAARKAKQGKENLWKEN 680
              +    E+  + + +K+ E E K  E  ++ K+++      E   K ++ +E +W++ 
Sbjct: 594 -EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652

Query: 681 LRKEEEEKQKRLQEEKTQ---EKIQEEERK---AEEKQRKDKDTLKAEEKK 725
            +  E+E++ R QEEK Q   EK++E+E K    EEK R+ ++ ++ +E+K
Sbjct: 653 EKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEK 703



 Score =  103 bits (256), Expect = 2e-21
 Identities = 105/422 (24%), Positives = 212/422 (50%), Gaps = 64/422 (15%)

Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQKEKE---EW 404
           KM+E+E + +     ++KR    E+   EL ++ + L EQ++ RE E + Q+++E   E 
Sbjct: 270 KMREQEEKMRR----QEKRLREQEK---ELREQEKELREQKKLREQEEQMQEQEEKMWEQ 322

Query: 405 ERKQRELQEQEWKKQLEL---EKRLEKQRELERQREEE--------RRKDIERREAAKQE 453
           E K RE +E+ W+++  L   EK++ +Q +  R +EE         R K+   RE  K  
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382

Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLH----LELEALNGKHQQISGRL 509
            + ++  E ERIR +E   +K RE+EE +R   +K         E E    + Q++  + 
Sbjct: 383 EQEEKMQEEERIRERE---KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 439

Query: 510 QDVRLKKQTQKTELEVLDKQ---CDLEIM---EIKQLQQELQEYQNKLIYLVPEK----- 558
           + +  +++ Q+ E ++ +++    D E M   E K  +QE    Q   ++   EK     
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499

Query: 559 QLLNERIKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET---ASKLSEM 613
           Q + ++ + M  Q     +    +  +K + ++E   R +++    EK+T     K+ E 
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559

Query: 614 DSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK 673
           +    + K++RE         E++ + + +K++E E K  E  +K   ++E   K ++ +
Sbjct: 560 ERMREREKKMREE--------EEMMREQEEKMQEQEEKMREQEEKMWEQEE---KMQEQE 608

Query: 674 ENLWKENLRKEEEEKQKRLQEEKT-----QEKIQEEERKA---EEKQRKDKDTLKAEEKK 725
           E +W++  +  E+E++ ++QE++      +EK+QE+E K    EEK R+ ++ ++ +E+K
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668

Query: 726 RE 727
            +
Sbjct: 669 MQ 670



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 92/401 (22%), Positives = 199/401 (49%), Gaps = 48/401 (11%)

Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WERKQR 409
           ++EE  ++    +E + K   E    E EK+ +   E+  RE E K QK++E  WE++++
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEENMWEQEEK 428

Query: 410 ELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE------ 461
           E Q+Q   +Q E     EK +E E +   +EE+ +D E     ++++ RQ ++       
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488

Query: 462 WE-----RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
           WE     R + Q++ +Q+ R  E+  RL  K++ +         + +++  + + +R +K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR--------EQKKMWQQEEKMREEK 540

Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
           +TQ+ E +  D++      E  + ++ ++E + K+     E++++ E+ + MQ     + 
Sbjct: 541 KTQEQEKKTWDQE------EKMREEERMREREKKMR---EEEEMMREQEEKMQ---EQEE 588

Query: 577 GVSLLHKKSLEKEELCQRLKEQL-----DALEKETASKLSEMDSFNNQLKELRETYNTQQ 631
            +    +K  E+EE  Q  +E++        E+E   K+ E +    + +E  +    + 
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648

Query: 632 LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE----- 686
              E+  + + +K++E E K ++  ++K  E E   + ++ K    +E +R +EE     
Sbjct: 649 WEQEEKMREQEEKMREQEEK-MQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ 707

Query: 687 EKQKRLQEEKT--QEKIQEEERKAEEKQRKDKDTLKAEEKK 725
           E++   QEEK   QE+++E+E +  +++ K ++ L   E++
Sbjct: 708 EEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEER 748



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 90/393 (22%), Positives = 192/393 (48%), Gaps = 18/393 (4%)

Query: 361 VTFEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE-LQEQEWKK 418
           +T E+ +K N E +  + L +  ++ ++   +E +RK ++ K    + Q   LQE+ W++
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239

Query: 419 QLEL---EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
           + EL   EK++ KQ E +  R+EER ++   +E   +E E + R + +R+R QE   ++ 
Sbjct: 240 EEELREQEKKIRKQEE-KMWRQEERLRE---QEGKMREQEEKMRRQEKRLREQE---KEL 292

Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIM 535
           REQE+ +R   K +    +++    K  +   ++++   K   Q+  L   +KQ   +  
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352

Query: 536 EIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRL 595
           +++  ++ + E Q++ +    E+    E++   +     +  +    KK  E+EE  +  
Sbjct: 353 KMRDQEERMWE-QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411

Query: 596 KEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL 655
           +E++   ++E   +  E +    +L E +E    Q+   EQ  KI   + K  +++ +  
Sbjct: 412 EEKMQK-QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470

Query: 656 MQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 715
            +KK    E   K ++ ++ +W++  +  ++E++   QEE+  E+  E  R+ EE+ R+ 
Sbjct: 471 QEKKMWRQE---KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ-DERLREKEERMREQ 526

Query: 716 KDTLKAEEKKRETASVLVNYRALYPFEARNHDE 748
           K   + EEK RE        +  +  E +  +E
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 103/408 (25%), Positives = 213/408 (52%), Gaps = 41/408 (10%)

Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
           K +  E Q+KL +   +K +   N +    +LE+ +  L + Q    + +  +++EE   
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245

Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWERI 465
           +++++++QE K   + E+  E++ ++  Q E+ RR++   RE  K+  E+++ L E +++
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305

Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
           R QE   ++ +EQEE  ++  +++ +  + E +  + +++  + + +R ++Q  + + E 
Sbjct: 306 REQE---EQMQEQEE--KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360

Query: 526 LDKQCD--LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM-QFSNTPDSGVSLLH 582
           + +Q +   E  E  + Q+++ E + K+     E++ + ER K M +   T       + 
Sbjct: 361 MWEQDERLREKEERMREQEKMWEQEEKM----QEEERIREREKKMREEEETMREQEEKMQ 416

Query: 583 K------KSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
           K      +  EKE   QRL EQ     KE   +  +M     ++ E  E    Q+    Q
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQ-----KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471

Query: 637 LYKI-KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK--ENLRKEEE--EKQKR 691
             K+ +++K++E E +  E  Q++K+ D+  +   Q +E +W+  E LR++EE   +QK+
Sbjct: 472 EKKMWRQEKMREQEDQMWE--QEEKMRDQEQKMWDQ-EERMWEQDERLREKEERMREQKK 528

Query: 692 L--QEEKTQE--KIQEEERKA---EEKQRKDKDTLKAEEKKRETASVL 732
           +  QEEK +E  K QE+E+K    EEK R+++   + E+K RE   ++
Sbjct: 529 MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 576



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 90/362 (24%), Positives = 182/362 (50%), Gaps = 42/362 (11%)

Query: 372 ERGNMELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
           ER  + LE  R  +  ++  ++ AE + +    E E+ + +L  +E K++LE  K L  Q
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQ 226

Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEW---ERIRRQELLNQKNREQEEIVRLNS 486
            +    +EE  R++ E RE  K+ + +Q    W   ER+R QE    K REQEE +R   
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQE---GKMREQEEKMRRQE 282

Query: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
           K+         L  + +++  + +++R +K+ ++ E ++ +++  +   E K  +QE + 
Sbjct: 283 KR---------LREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333

Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
           ++ +      EKQ+  +     Q     +  +    ++  EKEE   R++EQ    E+E 
Sbjct: 334 WRQEERLWEQEKQMREQE----QKMRDQEERMWEQDERLREKEE---RMREQEKMWEQE- 385

Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 666
             K+ E +    + K++RE   T +   E++ K + +  ++ E++     Q+++L ++  
Sbjct: 386 -EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE----WQQQRLPEQ-- 438

Query: 667 RKAKQGKENLWKENLRKEEEEKQKRLQEE-KTQEKIQEEERK--AEEKQRKDKDTLKAEE 723
                 KE LW++   +E+EEK    +E+ + QE++  +E+K   +EK R+ +D +  +E
Sbjct: 439 ------KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492

Query: 724 KK 725
           +K
Sbjct: 493 EK 494



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 93/386 (24%), Positives = 181/386 (46%), Gaps = 61/386 (15%)

Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKK 418
           ED++KA+++     R  +E +     ++  Q+ E E      ++      R+ ++    +
Sbjct: 70  EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA----ARKFEDGNLGE 125

Query: 419 QLELEKRL--------EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
             +L  RL        E QR L       ++ D    E  K+       L    I  +EL
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185

Query: 471 LNQKNREQEEIVRL-NSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
             +KN E +E +RL  S+K  + L ++ L  K ++    L  V    QT   + E+  ++
Sbjct: 186 -KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV----QTNTLQEEMWRQE 240

Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
            +L   E K  +QE + ++ +            ER++  +              K  E+E
Sbjct: 241 EELREQEKKIRKQEEKMWRQE------------ERLREQE-------------GKMREQE 275

Query: 590 ELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIE 649
           E  +R +++L   EKE    L E +    + K+LRE     Q   E++++ + +K++E E
Sbjct: 276 EKMRRQEKRLREQEKE----LREQEKELREQKKLREQEEQMQEQEEKMWE-QEEKMREQE 330

Query: 650 ----RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE--KTQEKIQE 703
               R+   L +++K   E  +K +  +E +W+++ R  E+E++ R QE+  + +EK+QE
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390

Query: 704 EE--RKAEEKQRKDKDTLKAEEKKRE 727
           EE  R+ E+K R++++T++ +E+K +
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQ 416



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 52/218 (23%), Positives = 117/218 (53%), Gaps = 11/218 (5%)

Query: 348 QKMQEEEP-QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
           +KM+EE+  Q++   T++ + K   E    E EK+ +   E+  RE E K Q+++E+   
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE-EEEMMREQEEKMQEQEEKMRE 592

Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQE-LERQRRLEWERI 465
           ++ ++ EQE K Q + EK  E++ ++  Q EE++ ++ E     ++E ++ Q    WE+ 
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652

Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
            +     +K REQEE  ++  +++ +  + E + G+ +++  R Q+ +++ Q +K   + 
Sbjct: 653 EKMREQEEKMREQEE--KMQGQEEKMREQEEKMQGQEEKM--REQEEKMRGQEEKMWGQE 708

Query: 526 LDKQCDLEIM----EIKQLQQELQEYQNKLIYLVPEKQ 559
                  E M    E+++ ++ +++ + K+   +PE +
Sbjct: 709 EKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 88/368 (23%), Positives = 161/368 (43%), Gaps = 100/368 (27%)

Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
           +KM+E+E Q      +E + K   +   M  ++ R    +++ RE E + +++K+ W+++
Sbjct: 479 EKMREQEDQM-----WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533

Query: 408 QRELQEQEWKKQLELEKRL----EKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
           ++  +E   KK  E EK+     EK RE ER R  ER K +   E   +E E + + + E
Sbjct: 534 EKMREE---KKTQEQEKKTWDQEEKMREEERMR--EREKKMREEEEMMREQEEKMQEQEE 588

Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT-E 522
           ++R QE   +K  EQEE                    K Q+     Q+ ++ +Q +K  E
Sbjct: 589 KMREQE---EKMWEQEE--------------------KMQE-----QEEKMWEQEEKMWE 620

Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
            E  DK  + E M  +Q ++++QE + K+                               
Sbjct: 621 QEEEDKMQEQEEMMWEQ-EEKMQEQEEKM------------------------------- 648

Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR 642
               E+EE   +++EQ    E++   +  +M     +++E  E    Q+           
Sbjct: 649 ---WEQEE---KMREQ----EEKMREQEEKMQGQEEKMREQEEKMQGQE----------- 687

Query: 643 DKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ 702
           +K++E E K     +K   ++E   K    +E +W +   +E+EE+  R Q+EK QE++ 
Sbjct: 688 EKMREQEEKMRGQEEKMWGQEE---KMWGQEEKMWGQEEMREKEER-IRDQKEKMQERLP 743

Query: 703 EEERKAEE 710
           E E +  E
Sbjct: 744 EHEERCSE 751



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 53/221 (23%), Positives = 117/221 (52%), Gaps = 31/221 (14%)

Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
           +KM+EEE   +     ++++    E    E E++     E+ Q + E+  ++E++ WE++
Sbjct: 567 KKMREEEEMMRE----QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622

Query: 408 QRE-LQEQE---WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
           + + +QEQE   W+++ +++++ EK  E E +  E+  K  E+ E  + + E+ R  E E
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE-E 681

Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
           +++ QE   +K REQEE +R   +K         + G+ +++ G+ + +  +++ ++ E 
Sbjct: 682 KMQGQE---EKMREQEEKMRGQEEK---------MWGQEEKMWGQEEKMWGQEEMREKEE 729

Query: 524 EVLDKQCDLEIMEIKQLQQELQEYQNKLI--YLVPEKQLLN 562
            + D++        +++Q+ L E++ +     L P K L N
Sbjct: 730 RIRDQK--------EKMQERLPEHEERCSEPCLPPSKVLCN 762


>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
            sapiens]
          Length = 646

 Score =  106 bits (264), Expect = 2e-22
 Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)

Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
            V A +++   NEDELSFSKG +I+V   ++  WW+G +NG TG FPSNYV+    S+ P 
Sbjct: 11   VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70

Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
                  L++     DT    +      +  +++TE  Y  +LQ V+  + + +  S  L+
Sbjct: 71   SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130

Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
               ++ +  N +E+      L+++L    K    +   Q +G      +  M+  Y+ +C
Sbjct: 131  SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187

Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
            +   +   +L + ++E  +F E   K AS P    + L++ L KP  R+ +YP L++ + 
Sbjct: 188  ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243

Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
             +  + H D   ++ ++   + L +Q  E  + KE
Sbjct: 244  RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
           RA + F+  N DE+SF+ GD+I V    V E GW  G+  G  GWFP NYV ++ +S  E
Sbjct: 12  RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67

Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
           K VSPK   L            S P   +  A    Y NV   N+
Sbjct: 68  KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 961  ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
            A + +      +L+F++G+ I VT+ ++G WW G++  R+G FPSNYV+         + 
Sbjct: 13   AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72

Query: 1020 KSGASNKKPE 1029
            KSG     P+
Sbjct: 73   KSGTLKSPPK 82



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)

Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
           L  +A  ++    ++ L+FSK D+I V   +E  WW G ++G  GWFP +YV+ +  SE
Sbjct: 9   LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
            sapiens]
          Length = 753

 Score =  106 bits (264), Expect = 2e-22
 Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)

Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
            V A +++   NEDELSFSKG +I+V   ++  WW+G +NG TG FPSNYV+    S+ P 
Sbjct: 139  VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 198

Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
                  L++     DT    +      +  +++TE  Y  +LQ V+  + + +  S  L+
Sbjct: 199  SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 258

Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
               ++ +  N +E+      L+++L    K    +   Q +G      +  M+  Y+ +C
Sbjct: 259  SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 315

Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
            +   +   +L + ++E  +F E   K AS P    + L++ L KP  R+ +YP L++ + 
Sbjct: 316  ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 371

Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
             +  + H D   ++ ++   + L +Q  E  + KE
Sbjct: 372  RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
           RA + F+  N DE+SF+ GD+I V    V E GW  G+  G  GWFP NYV ++ +S  E
Sbjct: 140 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 195

Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
           K VSPK   L            S P   +  A    Y NV   N+
Sbjct: 196 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 229



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 20/188 (10%)

Query: 756 IIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPK--------KALLP 806
           +++  +KT+ +P G+L  S +   G   C  +E++     EK               +L 
Sbjct: 16  VLESPKKTISDPEGFLQASLKD--GVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLS 73

Query: 807 PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT--VSPGSVSPI 864
             V+L+  +      S +  A  + ++  SF +L        +S  TRT  +  G    +
Sbjct: 74  SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLG------SQSLHTRTSKLFQGQYRSL 127

Query: 865 HGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSY 923
                    L  +A  ++    ++ L+FSK D+I V   +E  WW G ++G  GWFP +Y
Sbjct: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNY 187

Query: 924 VKIIPGSE 931
           V+ +  SE
Sbjct: 188 VREVKASE 195



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 961  ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
            A + +      +L+F++G+ I VT+ ++G WW G++  R+G FPSNYV+         + 
Sbjct: 141  AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200

Query: 1020 KSGASNKKPE 1029
            KSG     P+
Sbjct: 201  KSGTLKSPPK 210


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
            sapiens]
          Length = 803

 Score =  106 bits (264), Expect = 2e-22
 Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)

Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
            V A +++   NEDELSFSKG +I+V   ++  WW+G +NG TG FPSNYV+    S+ P 
Sbjct: 189  VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 248

Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
                  L++     DT    +      +  +++TE  Y  +LQ V+  + + +  S  L+
Sbjct: 249  SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 308

Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
               ++ +  N +E+      L+++L    K    +   Q +G      +  M+  Y+ +C
Sbjct: 309  SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 365

Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
            +   +   +L + ++E  +F E   K AS P    + L++ L KP  R+ +YP L++ + 
Sbjct: 366  ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 421

Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
             +  + H D   ++ ++   + L +Q  E  + KE
Sbjct: 422  RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
           RA + F+  N DE+SF+ GD+I V    V E GW  G+  G  GWFP NYV ++ +S  E
Sbjct: 190 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 245

Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
           K VSPK   L            S P   +  A    Y NV   N+
Sbjct: 246 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 279



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)

Query: 961  ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
            A + +      +L+F++G+ I VT+ ++G WW G++  R+G FPSNYV+         + 
Sbjct: 191  AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250

Query: 1020 KSGASNKKPE 1029
            KSG     P+
Sbjct: 251  KSGTLKSPPK 260



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)

Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
           L  +A  ++    ++ L+FSK D+I V   +E  WW G ++G  GWFP +YV+ +  SE
Sbjct: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 245


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,028,792
Number of Sequences: 37866
Number of extensions: 3271845
Number of successful extensions: 76394
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1228
Number of HSP's successfully gapped in prelim test: 1655
Number of HSP's that attempted gapping in prelim test: 18057
Number of HSP's gapped (non-prelim): 22038
length of query: 1670
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1554
effective length of database: 13,855,062
effective search space: 21530766348
effective search space used: 21530766348
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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