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Search of human proteins with 194097332
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097332 ephrin receptor EphB6 precursor [Homo sapiens]
(1021 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097332 ephrin receptor EphB6 precursor [Homo sapiens] 2086 0.0
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 935 0.0
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 935 0.0
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 932 0.0
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 885 0.0
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 785 0.0
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 784 0.0
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 783 0.0
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 763 0.0
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 759 0.0
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 756 0.0
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 739 0.0
gi|145312251 EPH receptor A6 isoform a [Homo sapiens] 729 0.0
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 672 0.0
gi|150456460 EPH receptor A10 isofom 3 [Homo sapiens] 671 0.0
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 634 0.0
gi|32967314 ephrin receptor EphA3 isoform b precursor [Homo sapi... 404 e-112
gi|55770892 ephrin receptor EphA8 isoform 2 precursor [Homo sapi... 337 4e-92
gi|150456469 EPH receptor A10 isoform 2 [Homo sapiens] 209 8e-54
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 185 2e-46
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 185 2e-46
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 177 3e-44
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 167 6e-41
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 167 6e-41
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 167 6e-41
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 166 8e-41
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 164 5e-40
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 164 5e-40
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 162 2e-39
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 162 2e-39
>gi|194097332 ephrin receptor EphB6 precursor [Homo sapiens]
Length = 1021
Score = 2087 bits (5406), Expect = 0.0
Identities = 1021/1021 (100%), Positives = 1021/1021 (100%)
Query: 1 MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVS 60
MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVS
Sbjct: 1 MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVS 60
Query: 61 VLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVS 120
VLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVS
Sbjct: 61 VLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVS 120
Query: 121 GGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWA 180
GGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWA
Sbjct: 121 GGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWA 180
Query: 181 VGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFA 240
VGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFA
Sbjct: 181 VGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFA 240
Query: 241 SFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCR 300
SFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCR
Sbjct: 241 SFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCR 300
Query: 301 CQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSD 360
CQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSD
Sbjct: 301 CQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSD 360
Query: 361 PPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGG 420
PPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGG
Sbjct: 361 PPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGG 420
Query: 421 GGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAIN 480
GGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAIN
Sbjct: 421 GGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAIN 480
Query: 481 VSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS 540
VSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS
Sbjct: 481 VSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS 540
Query: 541 ETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSI 600
ETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSI
Sbjct: 541 ETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSI 600
Query: 601 LGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRE 660
LGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRE
Sbjct: 601 LGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRE 660
Query: 661 LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA 720
LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA
Sbjct: 661 LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA 720
Query: 721 AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA 780
AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA
Sbjct: 721 AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA 780
Query: 781 AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTT 840
AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTT
Sbjct: 781 AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTT 840
Query: 841 SSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQK 900
SSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQK
Sbjct: 841 SSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQK 900
Query: 901 DRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAI 960
DRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAI
Sbjct: 901 DRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAI 960
Query: 961 GLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVE 1020
GLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVE
Sbjct: 961 GLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVE 1020
Query: 1021 V 1021
V
Sbjct: 1021 V 1021
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sapiens]
Length = 986
Score = 935 bits (2417), Expect = 0.0
Identities = 476/1018 (46%), Positives = 660/1018 (64%), Gaps = 60/1018 (5%)
Query: 23 LLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPP 82
LLL+ + A+EE L+D+T T+E+GW+ +PP GW+EVS D+ RT++ C+V +
Sbjct: 10 LLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFES-- 67
Query: 83 GTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPD 142
Q+NWL+T F+ RRGA R H+ + FSVR CSS+ G+C+ETF LYY +A+ +
Sbjct: 68 --SQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATK 125
Query: 143 SVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFG 202
+ +W W KVDTIAADESF G R +++N + RSFG
Sbjct: 126 TFPNWMENPWVKVDTIAADESFSQVD-----------------LGGRV-MKINTEVRSFG 167
Query: 203 PLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTC 262
P+++ GFY+AFQD G C++L+AVR+F CP ++++ A F ET SGA SLVAA G+C
Sbjct: 168 PVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQET-LSGAESTSLVAARGSC 226
Query: 263 VAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLY 322
+A+AE + P +L+CNG+G+W+V +G C C+ G++ C+ CP G +
Sbjct: 227 IANAEEVD---------VPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTF 277
Query: 323 KSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQG 382
K++ G+ C+ CP S + A C C G+YRA DP + PCT PSAPQ + V
Sbjct: 278 KANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNE 337
Query: 383 SALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTE 442
++LML W PR+ GGR DL++N++CK C G G C RC D V + PRQ GLTE
Sbjct: 338 TSLMLEWTPPRDSGGREDLVYNIICKSC-------GSGRGACTRCGDNVQYAPRQLGLTE 390
Query: 443 SRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASN 502
R+ + L AH Y E+QAVNGV++ SP PQ A++N++T+ PSAV ++HQVSR +
Sbjct: 391 PRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD 450
Query: 503 SITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRA 562
SIT+SW QPDQ NG ILDY+L+YY++ E ++ + S TNT TV L G IY FQVRA
Sbjct: 451 SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRA 510
Query: 563 RTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRK 622
RT AG+G Y GK+YFQT+ + E + + E+L L+IGS L FL+ A+ V+A+V R+
Sbjct: 511 RTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLI--AVVVIAIVCNRR 568
Query: 623 ---RRGTGYTEQLQQYSSPGL--GVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIG 677
R + YT++LQ Y+S + G+K YIDP TYEDP +A+RE A+E+D + +KIE+VIG
Sbjct: 569 GFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIG 628
Query: 678 TGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGV 737
G FGEV G L+ G+RE VAI+ L +G E + FL A+++GQF HPN++ LEGV
Sbjct: 629 AGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGV 688
Query: 738 VTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLS 797
VTKS P+M++TEFME G LDSFLRQ +GQF+ +QLV M RG+AA M+YL+ +VHR L+
Sbjct: 689 VTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLA 748
Query: 798 AHSVLVNSHLVCKVARLGHS---------PQGPSCL-----LRWAAPEVIAHGKHTTSSD 843
A ++LVNS+LVCKV+ G S P S L +RW APE I + K T++SD
Sbjct: 749 ARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASD 808
Query: 844 VWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRA 903
VWS+GI+MWEVMSYGERPYWDM+ Q+V+NAIEQ++RLPPP CP LH LMLD WQKDR
Sbjct: 809 VWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRN 868
Query: 904 RRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLE 963
RP F Q+V DKMIR P++L+A + LL D+ ++ WL AI +
Sbjct: 869 HRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMG 928
Query: 964 CYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV 1021
Y+++F+ G +F V+Q+ +ED+ +G+TLAGHQKK+L+ IQ+++ + Q SVEV
Sbjct: 929 QYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV 986
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapiens]
Length = 987
Score = 935 bits (2416), Expect = 0.0
Identities = 476/1019 (46%), Positives = 660/1019 (64%), Gaps = 61/1019 (5%)
Query: 23 LLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPP 82
LLL+ + A+EE L+D+T T+E+GW+ +PP GW+EVS D+ RT++ C+V +
Sbjct: 10 LLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFES-- 67
Query: 83 GTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPD 142
Q+NWL+T F+ RRGA R H+ + FSVR CSS+ G+C+ETF LYY +A+ +
Sbjct: 68 --SQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATK 125
Query: 143 SVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFG 202
+ +W W KVDTIAADESF G R +++N + RSFG
Sbjct: 126 TFPNWMENPWVKVDTIAADESFSQVD-----------------LGGRV-MKINTEVRSFG 167
Query: 203 PLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTC 262
P+++ GFY+AFQD G C++L+AVR+F CP ++++ A F ET SGA SLVAA G+C
Sbjct: 168 PVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQET-LSGAESTSLVAARGSC 226
Query: 263 VAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLY 322
+A+AE + P +L+CNG+G+W+V +G C C+ G++ C+ CP G +
Sbjct: 227 IANAEEVD---------VPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTF 277
Query: 323 KSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQG 382
K++ G+ C+ CP S + A C C G+YRA DP + PCT PSAPQ + V
Sbjct: 278 KANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNE 337
Query: 383 SALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTE 442
++LML W PR+ GGR DL++N++CK C G G C RC D V + PRQ GLTE
Sbjct: 338 TSLMLEWTPPRDSGGREDLVYNIICKSC-------GSGRGACTRCGDNVQYAPRQLGLTE 390
Query: 443 SRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASN 502
R+ + L AH Y E+QAVNGV++ SP PQ A++N++T+ PSAV ++HQVSR +
Sbjct: 391 PRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD 450
Query: 503 SITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRA 562
SIT+SW QPDQ NG ILDY+L+YY++ E ++ + S TNT TV L G IY FQVRA
Sbjct: 451 SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRA 510
Query: 563 RTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRK 622
RT AG+G Y GK+YFQT+ + E + + E+L L+IGS L FL+ A+ V+A+V R+
Sbjct: 511 RTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLI--AVVVIAIVCNRR 568
Query: 623 R----RGTGYTEQLQQYSSPGL--GVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVI 676
R + YT++LQ Y+S + G+K YIDP TYEDP +A+RE A+E+D + +KIE+VI
Sbjct: 569 RGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVI 628
Query: 677 GTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEG 736
G G FGEV G L+ G+RE VAI+ L +G E + FL A+++GQF HPN++ LEG
Sbjct: 629 GAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEG 688
Query: 737 VVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSL 796
VVTKS P+M++TEFME G LDSFLRQ +GQF+ +QLV M RG+AA M+YL+ +VHR L
Sbjct: 689 VVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDL 748
Query: 797 SAHSVLVNSHLVCKVARLGHS---------PQGPSCL-----LRWAAPEVIAHGKHTTSS 842
+A ++LVNS+LVCKV+ G S P S L +RW APE I + K T++S
Sbjct: 749 AARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSAS 808
Query: 843 DVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDR 902
DVWS+GI+MWEVMSYGERPYWDM+ Q+V+NAIEQ++RLPPP CP LH LMLD WQKDR
Sbjct: 809 DVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDR 868
Query: 903 ARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGL 962
RP F Q+V DKMIR P++L+A + LL D+ ++ WL AI +
Sbjct: 869 NHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKM 928
Query: 963 ECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV 1021
Y+++F+ G +F V+Q+ +ED+ +G+TLAGHQKK+L+ IQ+++ + Q SVEV
Sbjct: 929 GQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV 987
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 932 bits (2409), Expect = 0.0
Identities = 480/1017 (47%), Positives = 653/1017 (64%), Gaps = 65/1017 (6%)
Query: 20 LWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAG 79
L +LLL S+V A+EE L+DT T+E+GW P GW+EVS D+ RT++ C+V
Sbjct: 6 LLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFE 65
Query: 80 APPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPD 139
Q+NWL T F+ RRGA R + + F+VR CSSL G+C+ETF LYY + +
Sbjct: 66 P----NQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVI 121
Query: 140 SPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKER 199
+ + W + KVDTIAADESF +++N + R
Sbjct: 122 ATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRL------------------MKVNTEVR 163
Query: 200 SFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAV 259
SFGPLT+ GFY+AFQD GAC++L++VR+F CP+++++FA FPET +GA SLV A
Sbjct: 164 SFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETM-TGAESTSLVIAR 222
Query: 260 GTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPR 319
GTC+ +AE + P +L+CNG+G+WMV +G C C+PGY+P AC+ACP
Sbjct: 223 GTCIPNAEEVD---------VPIKLYCNGDGEWMVPIGRCTCKPGYEP-ENSVACKACPA 272
Query: 320 GLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFE 379
G +K+S CS CP+ S +P A+P+C C G+YRA DPPE CT PS P+ +
Sbjct: 273 GTFKASQEAEGCSHCPSNSRSPAEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISI 332
Query: 380 VQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRG 439
V ++++L W PRE GGR D+ +N++CK+C + +C RC D V F PRQ G
Sbjct: 333 VNETSIILEWHPPRETGGRDDVTYNIICKKCRADRR-------SCSRCDDNVEFVPRQLG 385
Query: 440 LTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSR 499
LTE RV + L AH PY ++QA+NGVS SP PPQ ++N++T+ PS VP++HQVS
Sbjct: 386 LTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSA 445
Query: 500 ASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQ 559
SIT+SWPQP+Q NG ILDY++RYY++ +E +S S+TNTA + L PG +Y Q
Sbjct: 446 TMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQ 505
Query: 560 VRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVF 619
VRART AG+G + GK+ FQTL + S+L E+L L+ GS + F++ ++ +++V
Sbjct: 506 VRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVV--SLVAISIVC 563
Query: 620 QRKR---RGTGYTEQLQQYS----SPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKI 672
RKR + Y+++LQ YS SPG+ K YIDP TYEDP +A+RE A+E+D +++KI
Sbjct: 564 SRKRAYSKEAVYSDKLQHYSTGRGSPGM--KIYIDPFTYEDPNEAVREFAKEIDVSFVKI 621
Query: 673 EEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNIL 732
EEVIG G FGEV +GRL+ G+RE VAI+ L AG +E + FL A+++GQF HPNI+
Sbjct: 622 EEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNII 681
Query: 733 RLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFV 792
RLEGVVTKSRP+M++TEFME G LDSFLRQ +GQF+ +QLV M RG+AA M+YL+ +V
Sbjct: 682 RLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYV 741
Query: 793 HRSLSAHSVLVNSHLVCKVARLG--------------HSPQGPSCLLRWAAPEVIAHGKH 838
HR L+A ++LVNS+LVCKV+ G S G +RW APE IA+ K
Sbjct: 742 HRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKF 801
Query: 839 TTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTW 898
T++SDVWS+GI+MWEVMS+GERPYWDMS Q+V+NAIEQ++RLPPP CP LH LMLD W
Sbjct: 802 TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCW 861
Query: 899 QKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLS 958
QKDR RP F ++V DKMIR P +L+ PSQ LL DF + WLS
Sbjct: 862 QKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLS 921
Query: 959 AIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQ 1015
AI + Y+D+F G + V Q++ EDL +GITLAGHQKK+L+ I ++ + Q
Sbjct: 922 AIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMRVQISQ 978
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 885 bits (2286), Expect = 0.0
Identities = 471/1018 (46%), Positives = 637/1018 (62%), Gaps = 65/1018 (6%)
Query: 22 VLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAP 81
+LLL + ALEE L+DT TSE+ W ++P GW+EVS D+ RT++ C+V +
Sbjct: 28 LLLLPAGCRALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRES- 86
Query: 82 PGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSP 141
Q+NWL+T F+ RR QR ++ L F+VR C+S+ G+C+ETF L+Y +A+ +
Sbjct: 87 ---SQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVAS 143
Query: 142 DSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSF 201
S W + KVDTIA DESF + ++N K RSF
Sbjct: 144 ASSPFWMENPYVKVDTIAPDESFSRLDAG----------------------RVNTKVRSF 181
Query: 202 GPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGT 261
GPL++ GFY+AFQD GAC++L++VR F C + FA FPET +GA SLV A GT
Sbjct: 182 GPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPET-LTGAEPTSLVIAPGT 240
Query: 262 CVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGL 321
C+ +A P +L+CNG+G+WMV VG C C G++PA + C+ CP G
Sbjct: 241 CIPNAVEVS---------VPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGS 291
Query: 322 YKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQ 381
YK+ G PC PCP S +PAA +C C FYRA SD ++ CT PS P+ + V
Sbjct: 292 YKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVN 351
Query: 382 GSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLT 441
++L+L W PR+LGGR DLL+NV+CK+C G +GG C RC D V F PRQ GLT
Sbjct: 352 ETSLILEWSEPRDLGGRDDLLYNVICKKCHG-----AGGASACSRCDDNVEFVPRQLGLT 406
Query: 442 ESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRAS 501
E RV + L AH Y EVQAVNGVS SP PP+ AA+N++T+ PS VP + S +
Sbjct: 407 ERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSG 466
Query: 502 NSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVR 561
+S+T+SW P++ NG ILDY+++Y++++E + T+TS+ N+ + L P Y QVR
Sbjct: 467 SSLTLSWAPPERPNGVILDYEMKYFEKSEGIAS--TVTSQMNSVQLDGLRPDARYVVQVR 524
Query: 562 ARTAAGHGPYGGKVYFQTLPQ-GELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQ 620
ART AG+G Y F+T + G + QL E+L L++GS L F++ A+ V+A+V
Sbjct: 525 ARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAGLVFVV--AVVVIAIVCL 582
Query: 621 RKRR---GTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIG 677
RK+R + YTE+LQQY +PG+ K YIDP TYEDP +A+RE A+E+D + +KIEEVIG
Sbjct: 583 RKQRHGSDSEYTEKLQQYIAPGM--KVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIG 640
Query: 678 TGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGV 737
G FGEV +GRL+ GRRE VAI+ L G E + FL A+++GQF HPNI+RLEGV
Sbjct: 641 AGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGV 700
Query: 738 VTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLS 797
VTKSRP+M+LTEFME LDSFLR +GQF+ +QLV M RG+AA M+YLS +VHR L+
Sbjct: 701 VTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLA 760
Query: 798 AHSVLVNSHLVCKVARLGHS------PQGPSCL--------LRWAAPEVIAHGKHTTSSD 843
A ++LVNS+LVCKV+ G S P P+ +RW APE IA+ K T++SD
Sbjct: 761 ARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASD 820
Query: 844 VWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRA 903
VWS+GI+MWEVMSYGERPYWDMS Q+V+NA+EQ++RLPPP CP LH LMLD W +DR
Sbjct: 821 VWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRN 880
Query: 904 RRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLE 963
RP F Q+V DK+IR +L+ SQ LL D+ + WL AI +
Sbjct: 881 LRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMG 940
Query: 964 CYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV 1021
Y+++F G +F VAQ++ EDL +G+TLAGHQKK+L IQ ++ + Q V+V
Sbjct: 941 RYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV 998
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 785 bits (2028), Expect = 0.0
Identities = 417/1026 (40%), Positives = 617/1026 (60%), Gaps = 77/1026 (7%)
Query: 16 MVCSLWVLLLV---SSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTF 72
++C +W+L + A E +LLD+ + +E+ W++ PP GW+E+S LD+ RT+
Sbjct: 12 ILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTY 71
Query: 73 EACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYY 132
+ C V Q+NWL+T+++ + AQR + L F++R C+SL GTC+ETF LYY
Sbjct: 72 QVCQVMEP----NQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYY 127
Query: 133 RQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGL 192
+ + D+ + + K+DTIAADESF G+R +
Sbjct: 128 YETDY----DTGRNIRENLYVKIDTIAADESFTQGD-----------------LGERK-M 165
Query: 193 QLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGG 252
+LN + R GPL+++GFY+AFQD GAC+ALV+V+++ C +++ + A FP+T +G+
Sbjct: 166 KLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDT-VTGSEF 224
Query: 253 ASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 312
+SLV GTCV+ AE E + PR+HC+ EG+W+V +G C C+ GYQ +GD
Sbjct: 225 SSLVEVRGTCVSSAEEEAENA--------PRMHCSAEGEWLVPIGKCICKAGYQQ-KGD- 274
Query: 313 ACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSA 372
C+ C RG YKSS+ + CS CP S + + C C +G+YRA SDPP CT PPSA
Sbjct: 275 TCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSA 334
Query: 373 PQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVH 432
PQ L F + + + L W P + GGR D+ + ++CK C Q G C C +
Sbjct: 335 PQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQ-------GECVPCGSNIG 387
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVP 492
+ P+Q GL ++ V V L AH Y EV+AVNGVS+LS AA++++T PS V
Sbjct: 388 YMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVS 447
Query: 493 VVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSP 552
V + S+ +SW +P+ NG I +Y+++YY++ + E T+ +++ +A++ L P
Sbjct: 448 GVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKP 507
Query: 553 GHIYGFQVRARTAAGHGPYGGKVYFQTLPQG-----ELSSQLPERLSLVIGSILGALAFL 607
G +Y FQ+RA TAAG+G Y ++ TL + E ++ E+ ++I +++ +
Sbjct: 508 GTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTI 567
Query: 608 LLAAITVLAVVFQRKRRGTGYTEQLQQ--------YSSPGLGVKYYIDPSTYEDPCQAIR 659
+L + ++ RR GY++ Q+ + PG K YIDP TYEDP +A+
Sbjct: 568 ILVFMVFGFII---GRRHCGYSKADQEGDEELYFHFKFPG--TKTYIDPETYEDPNRAVH 622
Query: 660 ELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGR 719
+ A+E+D + IKIE VIG G FGEV GRL+ G+R+ VAI+ L G E + FL
Sbjct: 623 QFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCE 682
Query: 720 AAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGV 779
A+++GQF HPN++ LEGVVT+ +P+M++ EFME G LD+FLR+ +GQF+ +QLV M RG+
Sbjct: 683 ASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGI 742
Query: 780 AAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG------------HSPQGPSCLLRW 827
AA M+YL+ +VHR L+A ++LVNS+LVCKV+ G ++ G +RW
Sbjct: 743 AAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW 802
Query: 828 AAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCP 887
APE I + K T++SDVWS+GI+MWEVMSYGERPYWDMS Q+V+ AIE+ +RLP P CP
Sbjct: 803 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCP 862
Query: 888 PGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDF 947
GLH LMLD WQK+RA RP F+Q+V DKMIR P++L+ RP LL DF
Sbjct: 863 AGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDF 922
Query: 948 PCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQ 1007
S WL AI +E Y+DNF+ G + VA++++ED+ +LGITL GHQKK++ IQ
Sbjct: 923 TTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQ 982
Query: 1008 LLQQHL 1013
++ +
Sbjct: 983 TMRAQM 988
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 784 bits (2025), Expect = 0.0
Identities = 432/1014 (42%), Positives = 607/1014 (59%), Gaps = 67/1014 (6%)
Query: 22 VLLLVSSVLALEEVLLDTTGETSEIGWLTYPP--GGWDEVSVLDDQRRLTRTFEACHVAG 79
+L S ALEE LL+T ET+++ W+T+P G W+E+S LD+++ RT+E C V
Sbjct: 6 LLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQR 65
Query: 80 APPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPD 139
AP GQ +WL+T +V RRGA + L F++ C SL +G +C+ETFT++Y +++
Sbjct: 66 AP---GQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADT 122
Query: 140 SPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKER 199
+ +W + KVDT+AA+ + A A G ++NVK
Sbjct: 123 ATALTPAWMENPYIKVDTVAAEHL--------TRKRPGAEATG----------KVNVKTL 164
Query: 200 SFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAV 259
GPL++ GFY+AFQD GAC+AL+++ LF C + + FPET +V
Sbjct: 165 RLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPREL----VVPVA 220
Query: 260 GTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVA-VGGCRCQPGYQPARGDKACQACP 318
G+CV A P A G P L+C +G+W V GC C PG++ A G+ C+AC
Sbjct: 221 GSCVVDAVP--------APGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACA 272
Query: 319 RGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWF 378
+G +K +G C PCPA SH+ + VC C G++RA +DP APCT PPSAP+ +
Sbjct: 273 QGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVS 332
Query: 379 EVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQR 438
+ GS+L L W P E GGR DL + + C+EC GG+C C ++ FDP R
Sbjct: 333 RLNGSSLHLEWSAPLESGGREDLTYALRCRECRP--------GGSCAPCGGDLTFDPGPR 384
Query: 439 GLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVS 498
L E V+V GLR Y EV A+NGVS L+ P +NV+T EVP AV +
Sbjct: 385 DLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTR 444
Query: 499 RASNSITVSWPQPDQTNGNILDYQLRYYDQ-AEDESHSFTLTSETNTATVTQLSPGHIYG 557
+ +S++++W P +G +LDY+++Y+++ AE S L + N A + L G Y
Sbjct: 445 SSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYL 504
Query: 558 FQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGS-ILGALAFLLLAAITVLA 616
QVRAR+ AG+GP+G + + QT Q + S E+L+L+ G+ ++G + L++ + VL
Sbjct: 505 VQVRARSEAGYGPFGQEHHSQT--QLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLC 562
Query: 617 VVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVI 676
+ Q R Y+++ QY G G K YIDP TYEDP +A+RE A+E+D +Y+KIEEVI
Sbjct: 563 LRKQSNGREAEYSDKHGQYLI-GHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVI 621
Query: 677 GTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEG 736
G G FGEV +GRL+ G++E VAI+ L G E + FL A+++GQF+HPNI+RLEG
Sbjct: 622 GAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEG 681
Query: 737 VVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSL 796
VVT S P+M+LTEFME G LDSFLR +GQF+ +QLV M RG+A+ M+YL+ ++VHR L
Sbjct: 682 VVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDL 741
Query: 797 SAHSVLVNSHLVCKVARLG--------------HSPQGPSCLLRWAAPEVIAHGKHTTSS 842
+A ++LVNS+LVCKV+ G S G +RW APE IA K T++S
Sbjct: 742 AARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSAS 801
Query: 843 DVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDR 902
D WS+GI+MWEVMS+GERPYWDMS Q+V+NAIEQ++RLPPPP CP LH LMLD WQKDR
Sbjct: 802 DAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDR 861
Query: 903 ARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGL 962
RP F Q+V+A DKMIR P +L+ S LL + S WL AI +
Sbjct: 862 NARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKM 921
Query: 963 ECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQ 1016
Y+++F+ G +F V+Q+S EDL +G+TLAGHQKK+L + QH++ Q
Sbjct: 922 GRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASV----QHMKSQ 971
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 783 bits (2021), Expect = 0.0
Identities = 414/1001 (41%), Positives = 611/1001 (61%), Gaps = 66/1001 (6%)
Query: 31 ALEEVLLDTTGETSEIGWLTYP-PGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNW 89
A E LLD+ E+GW+ P GGW+EVS++D++ RT++ C+V Q+NW
Sbjct: 28 ANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEP----SQNNW 83
Query: 90 LQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHL 149
L+T ++ R GAQR +I + F++R C+SL GTC+ETF LYY +++ D
Sbjct: 84 LRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDN----DKERFIRE 139
Query: 150 KRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGF 209
++ K+DTIAADESF G R ++LN + R GPL+++GF
Sbjct: 140 NQFVKIDTIAADESFTQVD-----------------IGDRI-MKLNTEIRDVGPLSKKGF 181
Query: 210 YVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPE 269
Y+AFQD GAC+ALV+VR+F CP +R+ A FP+T +GA +SLV G+CV ++E +
Sbjct: 182 YLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDT-ITGADTSSLVEVRGSCVNNSEEK 240
Query: 270 EDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNA 329
+ P+++C +G+W+V +G C C G++ G+ CQAC G YK+ + +A
Sbjct: 241 D----------VPKMYCGADGEWLVPIGNCLCNAGHEERSGE--CQACKIGYYKALSTDA 288
Query: 330 PCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHW 389
C+ CP S++ A C C GF+RA +D PCT PPSAP L V +++ L W
Sbjct: 289 TCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEW 348
Query: 390 RLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGG 449
P+ GGR D+ +NVVCK+C +G C C VH+ P+Q GL ++V +
Sbjct: 349 SSPQNTGGRQDISYNVVCKKC------GAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITD 402
Query: 450 LRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWP 509
L AH Y E+ AVNGVS+ +P+P Q+ ++ V+T+ PS++ +V S+ ++W
Sbjct: 403 LLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWL 462
Query: 510 QPDQTNGNILDYQLRYYDQAEDE-SHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGH 568
+PD+ NG IL+Y+++YY++ ++E S+ T+ NT + L+P Y F VRARTAAG+
Sbjct: 463 EPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNT-DIKGLNPLTSYVFHVRARTAAGY 521
Query: 569 GPYGG--KVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGT 626
G + +V T+P + + LV S L +L+AA V+ +R+ + +
Sbjct: 522 GDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAF----VISRRRSKYS 577
Query: 627 GYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQ 686
++ + GV+ Y+DP TYEDP QA+RE A+E+D + IKIE+VIG G FGEV
Sbjct: 578 KAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCS 637
Query: 687 GRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMV 746
GRL+ G+RE VAI+ L AG + + FL A+++GQF HPNI+ LEGVVTK +P+M+
Sbjct: 638 GRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMI 697
Query: 747 LTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSH 806
+TE+ME G LD+FLR+ +G+F+ +QLV M RG+ + M+YLS ++VHR L+A ++LVNS+
Sbjct: 698 ITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN 757
Query: 807 LVCKVARLG------------HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEV 854
LVCKV+ G ++ +G +RW APE IA+ K T++SDVWS+GI+MWEV
Sbjct: 758 LVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEV 817
Query: 855 MSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAA 914
MSYGERPYWDMS Q+V+ AIE+ +RLPPP CP LH LMLD WQK+R+ RP F Q+V
Sbjct: 818 MSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNM 877
Query: 915 FDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGL 974
DK+IR P++L+ G RP+ ALL P + +F + S WL AI ++ Y+DNF+ G
Sbjct: 878 LDKLIRNPNSLKRTGTESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGY 937
Query: 975 CTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQ 1015
T V ++ EDL +GIT HQ K+L +Q ++ ++Q
Sbjct: 938 TTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRTQMQQ 978
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapiens]
Length = 983
Score = 763 bits (1969), Expect = 0.0
Identities = 411/1022 (40%), Positives = 611/1022 (59%), Gaps = 76/1022 (7%)
Query: 16 MVCSLWVLLLVS-SVL----------ALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDD 64
M C L +LLL+S SVL + E LLD+ E+GW++YP GW+E+S +D+
Sbjct: 1 MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE 60
Query: 65 QRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTC 124
RT++ C+V Q+NWL+T++V R AQ+ ++ L F++R C+S+ + GTC
Sbjct: 61 HYTPIRTYQVCNVMDH----SQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTC 116
Query: 125 RETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPH 184
+ETF LYY ++++ D + ++TK+DTIAADESF
Sbjct: 117 KETFNLYYMESDD----DHGVKFREHQFTKIDTIAADESFTQMD---------------- 156
Query: 185 GAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPE 244
G R L+LN + R GP+ ++GFY+AFQD GAC+ALV+VR++ CP +++ A FP+
Sbjct: 157 -LGDRI-LKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPD 214
Query: 245 TQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPG 304
T + SLV G+CV +++ E+ PPR++C+ EG+W+V +G C C G
Sbjct: 215 TVPMDS--QSLVEVRGSCVNNSKEED----------PPRMYCSTEGEWLVPIGKCSCNAG 262
Query: 305 YQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEA 364
Y+ RG CQAC G YK+ GN C+ CP S + C C ++RA DPP
Sbjct: 263 YEE-RGFM-CQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSM 320
Query: 365 PCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTC 424
CT PPS+P+ + + ++++L W P + GGR D+ FN++CK+C + C
Sbjct: 321 ACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQ-------C 373
Query: 425 HRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTS 484
C V F PRQ GLT + V V L AH Y E+ AVNGVSELS P Q AA++++T+
Sbjct: 374 EPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTN 433
Query: 485 HEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNT 544
PS V + + + NSI++SW +P+ NG ILDY+++YY++ E E+ L +
Sbjct: 434 QAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTN 493
Query: 545 ATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGAL 604
T++ L P IY FQ+RARTAAG+G K F+T P S E +V+ +I A+
Sbjct: 494 VTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISG--ESSQVVMIAISAAV 551
Query: 605 AFLLLAAIT-VLAVVFQRKRRGTGYTEQLQQYSSPGL---GVKYYIDPSTYEDPCQAIRE 660
A +LL + VL F + G E+ + + L G++ Y+DP TYEDP QA+ E
Sbjct: 552 AIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHE 611
Query: 661 LAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRA 720
A+E+D I I++V+G G FGEV GRL+ ++E +VAI+ L G E + FLG A
Sbjct: 612 FAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEA 671
Query: 721 AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVA 780
+++GQF HPNI+RLEGVVTKS+P+M++TE+ME G LDSFLR+ + QF+ +QLV M RG+A
Sbjct: 672 SIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIA 731
Query: 781 AAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG------------HSPQGPSCLLRWA 828
+ M+YLS +VHR L+A ++L+NS+LVCKV+ G ++ +G +RW
Sbjct: 732 SGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 791
Query: 829 APEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPP 888
+PE IA+ K T++SDVWS+GI++WEVMSYGERPYW+MS Q+V+ A+++ +RLPPP CP
Sbjct: 792 SPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPA 851
Query: 889 GLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFP 948
L+ LMLD WQKDR RP F+Q+V+ DK+IR P +L+ RPS LL +D
Sbjct: 852 ALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIT 911
Query: 949 CLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQL 1008
+ WL+ + ++ F+ + +A++S +D+ +G+T+ G QKK++ I+
Sbjct: 912 TFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKA 971
Query: 1009 LQ 1010
L+
Sbjct: 972 LE 973
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sapiens]
Length = 1015
Score = 759 bits (1960), Expect = 0.0
Identities = 407/1023 (39%), Positives = 599/1023 (58%), Gaps = 83/1023 (8%)
Query: 20 LWVLLLVSSVLAL-------EEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTF 72
LW LL+ + L E LLD+ ++GW+ +P GW+E+ +D+ T+
Sbjct: 40 LWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTY 99
Query: 73 EACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYY 132
+ C V Q+NWL T ++ GA R I L F++R C+SL GTC+ETF +YY
Sbjct: 100 QVCKVMEQ----NQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYY 155
Query: 133 RQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGL 192
++++ + + + ++K +DTIAADESF G R +
Sbjct: 156 FESDDQNGRNIKENQYIK----IDTIAADESFTELD-----------------LGDRV-M 193
Query: 193 QLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGG 252
+LN + R GPL+++GFY+AFQD GAC+ALV+VR++ CP+V+R A FP+T +GA
Sbjct: 194 KLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDT-ITGADS 252
Query: 253 ASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 312
+ L+ G+CV H+ +E PP++HC+ EG+W+V +G C C+ GY+ G
Sbjct: 253 SQLLEVSGSCVNHSVTDE----------PPKMHCSAEGEWLVPIGKCMCKAGYEEKNG-- 300
Query: 313 ACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSA 372
CQ C G +K+S C CP S+ A+ C C + ++R SDPP CT PPSA
Sbjct: 301 TCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSA 360
Query: 373 PQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVH 432
P+ V +++ L W P + GGR D+ + + CK+C G C C V
Sbjct: 361 PRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSH-------AGVCEECGGHVR 413
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVP 492
+ PRQ GL + V++ L AH Y E++AVNGVS+LSP Q ++NV+T+ PS V
Sbjct: 414 YLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVT 473
Query: 493 VVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSP 552
V + A NSI++SW +PD+ NG IL+Y+++Y+++ ++ S++ + ET T T L P
Sbjct: 474 NVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKET-TITAEGLKP 532
Query: 553 GHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAI 612
+Y FQ+RARTAAG+G + + F+T P SS + + + +G + LLA
Sbjct: 533 ASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVI---LLAV- 588
Query: 613 TVLAVVFQRKRRGTGYTEQLQQYSSPGL----------GVKYYIDPSTYEDPCQAIRELA 662
V+ V+ +R GY++ Q + GV+ YIDP TYEDP QA+ E A
Sbjct: 589 -VIGVLLSGRR--CGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFA 645
Query: 663 REVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAV 722
+E++ + I IE VIG G FGEV GRL+ G+RE VAI+ L G E + FLG A++
Sbjct: 646 KEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASI 705
Query: 723 LGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAA 782
+GQF HPNI+ LEGVVTKS+P+M++TE+ME G LD+FL++ +GQF+ +QLV M RG++A
Sbjct: 706 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 765
Query: 783 MQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG------------HSPQGPSCLLRWAAP 830
M+YLS +VHR L+A ++L+NS+LVCKV+ G ++ +G +RW AP
Sbjct: 766 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 825
Query: 831 EVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGL 890
E IA K T++SDVWS+GI+MWEV+SYGERPYW+M+ Q+V+ A+E+ +RLP P CP L
Sbjct: 826 EAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAAL 885
Query: 891 HLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCL 950
+ LMLD WQK+R RP FD++V DK+IR P +L+ + R S L L
Sbjct: 886 YQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAY 945
Query: 951 DSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQ 1010
S WL AI + Y + F + G + VAQ++LEDL LG+TL GHQKK+++ +Q ++
Sbjct: 946 RSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMK 1005
Query: 1011 QHL 1013
L
Sbjct: 1006 VQL 1008
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sapiens]
Length = 1037
Score = 756 bits (1953), Expect = 0.0
Identities = 411/1038 (39%), Positives = 603/1038 (58%), Gaps = 91/1038 (8%)
Query: 20 LWVLLLVSSVLAL-------EEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTF 72
LW LL+ + L E LLD+ ++GW+ +P GW+E+ +D+ T+
Sbjct: 40 LWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTY 99
Query: 73 EACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYY 132
+ C V Q+NWL T ++ GA R I L F++R C+SL GTC+ETF +YY
Sbjct: 100 QVCKVMEQ----NQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYY 155
Query: 133 RQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGL 192
++++ + + + ++K +DTIAADESF G R +
Sbjct: 156 FESDDQNGRNIKENQYIK----IDTIAADESFTELD-----------------LGDRV-M 193
Query: 193 QLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGG 252
+LN + R GPL+++GFY+AFQD GAC+ALV+VR++ CP+V+R A FP+T +GA
Sbjct: 194 KLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDT-ITGADS 252
Query: 253 ASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 312
+ L+ G+CV H+ +E PP++HC+ EG+W+V +G C C+ GY+ G
Sbjct: 253 SQLLEVSGSCVNHSVTDE----------PPKMHCSAEGEWLVPIGKCMCKAGYEEKNG-- 300
Query: 313 ACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSA 372
CQ C G +K+S C CP S+ A+ C C + ++R SDPP CT PPSA
Sbjct: 301 TCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSA 360
Query: 373 PQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVH 432
P+ V +++ L W P + GGR D+ + + CK+C G C C V
Sbjct: 361 PRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSH-------AGVCEECGGHVR 413
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVP 492
+ PRQ GL + V++ L AH Y E++AVNGVS+LSP Q ++NV+T+ PS V
Sbjct: 414 YLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVT 473
Query: 493 VVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSP 552
V + A NSI++SW +PD+ NG IL+Y+++Y+++ ++ S++ + ET T T L P
Sbjct: 474 NVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKET-TITAEGLKP 532
Query: 553 GHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSS---QLPE-RLSLVIGSILGALAFLL 608
+Y FQ+RARTAAG+G + + F+T P SS Q+P +S+ +G IL A+ +
Sbjct: 533 ASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGV 592
Query: 609 LA-----------AITVLAVVFQRKRRGTGYTEQLQQYSSPGL----------GVKYYID 647
L A ++ AV GY++ Q + GV+ YID
Sbjct: 593 LLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYID 652
Query: 648 PSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAG 707
P TYEDP QA+ E A+E++ + I IE VIG G FGEV GRL+ G+RE VAI+ L G
Sbjct: 653 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 712
Query: 708 GAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQF 767
E + FLG A+++GQF HPNI+ LEGVVTKS+P+M++TE+ME G LD+FL++ +GQF
Sbjct: 713 YTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQF 772
Query: 768 SSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG------------ 815
+ +QLV M RG++A M+YLS +VHR L+A ++L+NS+LVCKV+ G
Sbjct: 773 TVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAA 832
Query: 816 HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIE 875
++ +G +RW APE IA K T++SDVWS+GI+MWEV+SYGERPYW+M+ Q+V+ A+E
Sbjct: 833 YTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 892
Query: 876 QEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERP 935
+ +RLP P CP L+ LMLD WQK+R RP FD++V DK+IR P +L+ + R
Sbjct: 893 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRV 952
Query: 936 SQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITL 995
S L L S WL AI + Y + F + G + VAQ++LEDL LG+TL
Sbjct: 953 SNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTL 1012
Query: 996 AGHQKKLLHHIQLLQQHL 1013
GHQKK+++ +Q ++ L
Sbjct: 1013 VGHQKKIMNSLQEMKVQL 1030
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapiens]
Length = 1005
Score = 739 bits (1909), Expect = 0.0
Identities = 409/1047 (39%), Positives = 605/1047 (57%), Gaps = 114/1047 (10%)
Query: 19 SLWVLLLVSSVLAL------EEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTF 72
+LWV+ ++ E LLDT+ + GWLTYP GWD ++ +D+ + T+
Sbjct: 11 ALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQPIHTY 70
Query: 73 EACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYY 132
+ C+V Q+NWL+T +V R GA+R + + F++R C+S+ GTC+ETF LYY
Sbjct: 71 QVCNVMSP----NQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYY 126
Query: 133 RQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGL 192
+++ D +S ++ K+DTIAADESF + G R L
Sbjct: 127 LESDR----DLGASTQESQFLKIDTIAADESFTGAD-----------------LGVRR-L 164
Query: 193 QLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGG 252
+LN + RS GPL++RGFY+AFQD GACLA++++R++ CPA++R+ A+F E +GA
Sbjct: 165 KLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEA-VTGADS 223
Query: 253 ASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 312
+SLV G CV H+E + P+++C+ EG+W+V +G C C GY+ R
Sbjct: 224 SSLVEVRGQCVRHSEERDT----------PKMYCSAEGEWLVPIGKCVCSAGYEERRD-- 271
Query: 313 ACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSA 372
AC AC G YKS+ G+ C+ CP SH+ PAA C C +YRA+ DPP + CT PPSA
Sbjct: 272 ACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSACTRPPSA 331
Query: 373 PQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVH 432
P L V G+++ L W P + GGR D+ +N VC+ C C C
Sbjct: 332 PVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALS-------RCEACGSGTR 384
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVP 492
F P+Q L ++ +LV L AH+ Y ++AVNGVS+LSP+P +AA +N++T+ PS V
Sbjct: 385 FVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVV 444
Query: 493 VVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSP 552
V+ Q S+++ W +P+Q NG IL+Y+++YY++ ++ TL + T ATV+ L P
Sbjct: 445 VIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKP 504
Query: 553 GHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAI 612
G Y FQVRART+AG G + + +T G+ + R + I L+ +
Sbjct: 505 GTRYVFQVRARTSAGCGRFSQAMEVET---GKPRPRYDTRTIVWI-------CLTLITGL 554
Query: 613 TVLAVVFQRKRRGTGYTEQLQQ---------------------YSSPGL--GVKYYIDPS 649
VL ++ K+R GY++ Q + PG ++Y +P
Sbjct: 555 VVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHPPGKLPEPQFYAEPH 614
Query: 650 TYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGA 709
TYE+P +A R RE++ + I IE++IG+G GEV GRL+ G+R+ VAI+AL AG
Sbjct: 615 TYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYT 674
Query: 710 ESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSS 769
E + FL A+++GQF HPNI+RLEGVVT+ R M++TE+ME G LD+FLR +GQF+
Sbjct: 675 ERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTI 734
Query: 770 LQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG------------HS 817
+QLV M RGV A M+YLS +VHR L+A +VLV+S+LVCKV+ G ++
Sbjct: 735 MQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYT 794
Query: 818 PQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQE 877
G +RW APE IA +++SDVWSFG++MWEV++YGERPYW+M+ ++V++++E+
Sbjct: 795 TTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEG 854
Query: 878 FRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQ 937
+RLP P GCP LH LMLD W KDRA+RP F Q+V+ D +IR P++L+A P
Sbjct: 855 YRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATATVSRCP-- 912
Query: 938 ALLTPVALDFPCLD-----------SPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLE 986
P A C D + WL +I + Y+D+F+ G + V +++ +
Sbjct: 913 ----PPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQ 968
Query: 987 DLPALGITLAGHQKKLLHHIQLLQQHL 1013
D+ ALGITL GHQKK+L IQ ++ L
Sbjct: 969 DVRALGITLMGHQKKILGSIQTMRAQL 995
>gi|145312251 EPH receptor A6 isoform a [Homo sapiens]
Length = 1130
Score = 729 bits (1881), Expect = 0.0
Identities = 405/1054 (38%), Positives = 581/1054 (55%), Gaps = 138/1054 (13%)
Query: 35 VLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHF 94
VLLDTT E+GW TYP GWD ++ +D+ R T++ C+V Q+NWL+T++
Sbjct: 130 VLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEP----NQNNWLRTNW 185
Query: 95 VERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTK 154
+ R AQ+ ++ + F++R C+S+ GTC+ETF L+Y +++E + ++TK
Sbjct: 186 ISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHG----IKFKPNQYTK 241
Query: 155 VDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQ 214
+DTIAADESF G R L+LN + R GP+ ++GFY+AFQ
Sbjct: 242 IDTIAADESFTQMD-----------------LGDRI-LKLNTEIREVGPIERKGFYLAFQ 283
Query: 215 DTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVG 274
D GAC+ALV+VR+F CP +R+ A FP+T +SLV G+CV AE +
Sbjct: 284 DIGACIALVSVRVFYKKCPFTVRNLAMFPDT-IPRVDSSSLVEVRGSCVKSAEERDT--- 339
Query: 275 GQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAPCSPC 334
P+L+C +G W+V +G C C GY+ G +C AC G YK+ AGN CS C
Sbjct: 340 -------PKLYCGADGDWLVPLGRCICSTGYEEIEG--SCHACRPGFYKAFAGNTKCSKC 390
Query: 335 PARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRE 394
P S A VC C +G++RA DPP CT PPSAP+ + F + +AL+L W P +
Sbjct: 391 PPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSPPSD 450
Query: 395 LGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHV 454
GGR DL ++V+CK+C C C + F PR GL + V+V +HV
Sbjct: 451 TGGRKDLTYSVICKKC-------GLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHV 503
Query: 455 PYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQT 514
Y E++A+NGVSELS P AI V+T + PS + VV + + NSI +SW P +
Sbjct: 504 NYTFEIEAMNGVSELSFSPKPFTAITVTTDQDAPSLIGVVRKDWASQNSIALSWQAPAFS 563
Query: 515 NGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGK 574
NG ILDY+++YY++ ++ + S+ + +T L P Y F +R RTA G+ Y K
Sbjct: 564 NGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQK 623
Query: 575 VYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQR------------- 621
F+T E S E+ +++ + F LL +T+ ++ R
Sbjct: 624 FEFET--GDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEE 681
Query: 622 KRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSF 681
KRR LQ G+K YIDP TYEDP A+ E A+E+DP+ I+IE VIG G F
Sbjct: 682 KRRN-----HLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEF 736
Query: 682 GEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTK- 740
GEV GRL+ G+RE VAI+ L G + + FL A+++GQF HPNI+RLEGVVTK
Sbjct: 737 GEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKR 796
Query: 741 -----------------------------------------SRPLMVLTEFMELGPLDSF 759
RP+M++ E+ME G LDSF
Sbjct: 797 SFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSF 856
Query: 760 LRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG---- 815
LR+ +G F+ +QLV M RG+A+ M+YLS +VHR L+A ++LVNS+LVCKV+ G
Sbjct: 857 LRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRV 916
Query: 816 --------HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSE 867
++ G +RW APE IA+ K +++SD WS+GI+MWEVMSYGERPYW+MS
Sbjct: 917 LEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSN 976
Query: 868 QEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKP----- 922
Q+V+ +IE+ +RLP P GCP LH LML WQK+R RP F +V+ DK+IR P
Sbjct: 977 QDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHT 1036
Query: 923 ---DTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSD 979
D L PGE P ++P + WL +I + Y++NF G TF
Sbjct: 1037 LVEDILVMPESPGEVP----------EYPLFVTVGDWLDSIKMGQYKNNFVAAGFTTFDL 1086
Query: 980 VAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHL 1013
++++S++D+ +G+ L GHQ++++ IQ L+ H+
Sbjct: 1087 ISRMSIDDIRRIGVILIGHQRRIVSSIQTLRLHM 1120
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 672 bits (1735), Expect = 0.0
Identities = 393/1018 (38%), Positives = 573/1018 (56%), Gaps = 77/1018 (7%)
Query: 20 LWVLLLVSSVLAL--EEVLLDTTGETSEIGWLTYPPG-GWDEV-SVLDDQRRLTRTFEAC 75
LW L ++ A E VLLD E+GWLT+P G GWD + ++++D + C
Sbjct: 13 LWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMP--IYMYSVC 70
Query: 76 HVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQA 135
+V QDNWL+T++V R A+R I L F+VR C+S +C+ETF LYY ++
Sbjct: 71 NVMSGD----QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES 126
Query: 136 EEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLN 195
+ D +++ + +TK+DTIA DE SS + ++LN
Sbjct: 127 DL----DYGTNFQKRLFTKIDTIAPDEITVSSDFEARH------------------VKLN 164
Query: 196 VKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASL 255
V+ERS GPLT++GFY+AFQD GAC+AL++VR++ CP +L+ A FPET A G+ SL
Sbjct: 165 VEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIA-GSDAPSL 223
Query: 256 VAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQ 315
GTCV HA GG PR+HC +G+W+V +G C CQ GY+ + ACQ
Sbjct: 224 ATVAGTCVDHAVVPP-------GGEEPRMHCAVDGEWLVPIGQCLCQAGYEKV--EDACQ 274
Query: 316 ACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQE 375
AC G +K A +PC CP + A C C EGF+RA DP PCT PPSAP
Sbjct: 275 ACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHY 334
Query: 376 LWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDP 435
L G+ + L W P++ GGR D++++V C++C P SG C C V +
Sbjct: 335 LTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCW----PESG---ECGPCEASVRYSE 387
Query: 436 RQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVH 495
GLT + V V L H+ Y V+A NGVS L A +VS + P P V
Sbjct: 388 PPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTA-SVSINQTEP---PKVR 443
Query: 496 QVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHI 555
R++ S++VSW P + Y++ Y + + S++ T E + T+ L+P
Sbjct: 444 LEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRT-EGFSVTLDDLAPDTT 502
Query: 556 YGFQVRARTAAGHGPYGGKVY-FQTL-PQGELSSQLPERLSLVIGSILGALAFLLLAAIT 613
Y QV+A T G G G KV+ FQTL P+G L+++ G +G + L+LA +
Sbjct: 503 YLVQVQALTQEGQGA-GSKVHEFQTLSPEGS------GNLAVIGGVAVGVVLLLVLAGVG 555
Query: 614 VLAVVFQRKRRGTGYTEQLQQYSSPGLG-VKYYIDPSTYEDPCQAIRELAREVDPAYIKI 672
++ +R E + S L +K Y+DP TYEDP QA+ + E+ P+ +
Sbjct: 556 FFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTR 615
Query: 673 EEVIGTGSFGEVRQGRLQPR-GRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNI 731
++VIG G FGEV +G L+ G++E VAI+ L AG E ++ FLG A ++GQF H NI
Sbjct: 616 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNI 675
Query: 732 LRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAF 791
+RLEGV++K +P+M++TE+ME G LD FLR+++G+FS LQLV M RG+AA M+YL++ +
Sbjct: 676 IRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNY 735
Query: 792 VHRSLSAHSVLVNSHLVCKVARLG------------HSPQGPSCLLRWAAPEVIAHGKHT 839
VHR L+A ++LVNS+LVCKV+ G ++ G +RW APE I++ K T
Sbjct: 736 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFT 795
Query: 840 TSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQ 899
++SDVWSFGI+MWEVM+YGERPYW++S EV+ AI FRLP P CP ++ LM+ WQ
Sbjct: 796 SASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQ 855
Query: 900 KDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSA 959
++RARRP F +V+ DK+IR PD+L+ D R S L + + + WL +
Sbjct: 856 QERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLES 915
Query: 960 IGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQG 1017
I ++ Y ++F G V Q++ +D+ +G+ L GHQK++ + + L+ + G
Sbjct: 916 IKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVG 973
>gi|150456460 EPH receptor A10 isofom 3 [Homo sapiens]
Length = 1008
Score = 671 bits (1730), Expect = 0.0
Identities = 395/1017 (38%), Positives = 563/1017 (55%), Gaps = 81/1017 (7%)
Query: 31 ALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWL 90
A E +LLD+ +E+GW P GW+E+S +D+ R RT++ C+V QDNWL
Sbjct: 33 AEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEP----NQDNWL 88
Query: 91 QTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLK 150
QT ++ R QR + L F++R CSS+ + GTC+ETF +YY + E D
Sbjct: 89 QTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEA-DLGRGRPRLGGS 147
Query: 151 RWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFY 210
R K+DTIAADESF G+R ++LN + R GPL++RGF+
Sbjct: 148 RPRKIDTIAADESFTQGD-----------------LGERK-MKLNTEVREIGPLSRRGFH 189
Query: 211 VAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEE 270
+AFQD GAC+ALV+VR++ C A +R A+FP T A A ++LV GTCVAH+E E
Sbjct: 190 LAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESAF-STLVEVAGTCVAHSEGEP 248
Query: 271 DGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAP 330
GSPPR+HC +G+W+V VG C C G+Q RGD C+ACP G YK S
Sbjct: 249 --------GSPPRMHCGADGEWLVPVGRCSCSAGFQE-RGD-FCEACPPGFYKVSPRRPL 298
Query: 331 CSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLH-- 388
CSPCP S A A+ C C + + R+ +DPP A CT PPSAP++L + + S L+L
Sbjct: 299 CSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLR 358
Query: 389 WRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVG 448
W P + GGR D+ ++++C C GR+ PA G C C V F PRQ GL E +
Sbjct: 359 WLPPADSGGRSDVTYSLLCLRC-GREGPA----GACEPCGPRVAFLPRQAGLRERAATLL 413
Query: 449 GLRAHVPYILEVQAVNGVSELSPDPPQAAA------INVSTSHEVPSAVPVVHQVSRASN 502
LR Y + V A+NGVS P AAA + VST P + +
Sbjct: 414 HLRPGARYTVRVAALNGVSG-----PAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQ 468
Query: 503 SITVSWPQP---DQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQ 559
S+++SW +P N +Y++RYY++ + E + + T TVT L P Y FQ
Sbjct: 469 SVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQ 528
Query: 560 VRARTAAGHGP------YGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAIT 613
+RA A GP + + QTL GE +S ++ ++ +++ A L+L ++
Sbjct: 529 IRA---ASPGPSWEAQSFNPSIEVQTL--GEAASGSRDQSPAIVVTVVTISALLVLGSVM 583
Query: 614 VLAVVFQR-----KRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPA 668
+ +++R K G + E+ + + ++DP + D QA+ A+E+D
Sbjct: 584 SVLAIWRRPCSYGKGGGDAHDEEELYFHFKVPTRRTFLDPQSCGDLLQAVHLFAKELDAK 643
Query: 669 YIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQH 728
+ +E +G G FGE+ G LQ GR+E VA+ L ++S ++ FL A LGQF H
Sbjct: 644 SVTLERSLGGGRFGELCCGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDH 703
Query: 729 PNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSS 788
+I+RLEGVVT+ LM++TE+M G LD FLR+ EGQ + QL+ + G+A+AM+YLS
Sbjct: 704 SHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSE 763
Query: 789 FAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLR----------WAAPEVIAHGKH 838
+VHR L+A VLV+S LVCK++ G P+ S + WAAPE + G
Sbjct: 764 MGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTMSGRSPALWAAPETLQFGHF 823
Query: 839 TTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTW 898
+++SDVWSFGI+MWEVM++GERPYWDMS Q+V+ A+E FRLPPP CP LH LMLD W
Sbjct: 824 SSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCW 883
Query: 899 QKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLS 958
QKD RP F Q+ + KM++ P+ + RP L FP S AWL
Sbjct: 884 QKDPGERPRFSQIHSILSKMVQDPEPPKCALTTCPRPPTPLADRAFSTFPSFGSVGAWLE 943
Query: 959 AIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQ 1015
A+ L Y+D+F+ G + VA+++ +DL +LGI+LA H++ LL I LQ + Q
Sbjct: 944 ALDLCRYKDSFAAAGYGSLEAVAEMTAQDLVSLGISLAEHREALLSGISALQARVLQ 1000
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 634 bits (1635), Expect = 0.0
Identities = 377/1000 (37%), Positives = 533/1000 (53%), Gaps = 75/1000 (7%)
Query: 31 ALEEVLLDTTGETSEIGWLTYPP-GGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNW 89
A E L+DT+ E+GWL PP GW E + + L ++ C + G D+W
Sbjct: 25 AKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYM-YQDCPMQGR---RDTDHW 80
Query: 90 LQTHFVER-RGAQRAHIRLHFSVRACSSLGVSGGT--CRETFTLYYRQAEEPDSPDSVSS 146
L+++++ R A R H+ L F+VR C S G C+ETF L Y ++++ D
Sbjct: 81 LRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQ----DVGIQ 136
Query: 147 WHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQ 206
+ KV T+AAD+SF S S ++LNV+ S G LT+
Sbjct: 137 LRRPLFQKVTTVAADQSFTIRDLVSGS------------------VKLNVERCSLGRLTR 178
Query: 207 RGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHA 266
RG Y+AF + GAC+ALV+VR+F CP L A FP+T AG LV GTC+ HA
Sbjct: 179 RGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAG---LVEVAGTCLPHA 235
Query: 267 EPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSA 326
G PR+HC+ +G+W+V VG C C+PGY+ +AC ACP G Y+
Sbjct: 236 RASPRPSGA------PRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDM 289
Query: 327 GNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALM 386
C CP +S A + A +C C G YRA + P+ CTGPPSAP+ L F G+ L
Sbjct: 290 DTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLS 349
Query: 387 LHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVL 446
L W P + GGR D+ ++V C +C+G + GG C C VHF P RGLT V
Sbjct: 350 LRWEPPADTGGRQDVRYSVRCSQCQGTAQD----GGPCQPCGVGVHFSPGARGLTTPAVH 405
Query: 447 VGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITV 506
V GL + Y V+A NGVS L + ++++S H + + V + + +
Sbjct: 406 VNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLEL 465
Query: 507 SWP--QPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRART 564
+W +P N L Y+L +Q ++E + L +T+L P Y +VR T
Sbjct: 466 TWAGSRPRSPGAN-LTYELHVLNQ-DEERYQMVLEPRV---LLTELQPDTTYIVRVRMLT 520
Query: 565 AAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRR 624
G GP+ F+T P P L G I+ + LLL A +L ++ R RR
Sbjct: 521 PLGPGPFSPDHEFRTSP--------PVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRR 572
Query: 625 GTGYTEQLQQYSSPG------LGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGT 678
+Q Q+ + L +K Y+D YEDP Q + RE+DPA++ ++ VIG
Sbjct: 573 AQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGE 632
Query: 679 GSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVV 738
G FGEV +G L+ + +TVAI+ L FL A ++GQF HP+IL LEGVV
Sbjct: 633 GEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVV 692
Query: 739 TKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSA 798
TK +P+M++TEFME G LD+FLR+RE Q QLVAM +G+A+ M YLS+ +VHR L+A
Sbjct: 693 TKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAA 752
Query: 799 HSVLVNSHLVCKVARLG-----------HSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSF 847
++LVN +L CKV+ G + QG +RW APE IAH TT+SDVWSF
Sbjct: 753 RNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSF 812
Query: 848 GILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPH 907
GI+MWEV+S+G++PY +MS QEV+ +IE +RLPPP CP L+ LM + W DRARRPH
Sbjct: 813 GIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPH 872
Query: 908 FDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQD 967
F +L A ++++ P +L+ + R + L + D + WL +I ++ Y
Sbjct: 873 FQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIPYRTVSEWLESIRMKRYIL 932
Query: 968 NFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQ 1007
+F GL T V +L+ EDL +GITL GHQK++L IQ
Sbjct: 933 HFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQ 972
>gi|32967314 ephrin receptor EphA3 isoform b precursor [Homo
sapiens]
Length = 539
Score = 404 bits (1037), Expect = e-112
Identities = 222/577 (38%), Positives = 329/577 (57%), Gaps = 58/577 (10%)
Query: 16 MVCSLWVLLLVS-SVL----------ALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDD 64
M C L +LLL+S SVL + E LLD+ E+GW++YP GW+E+S +D+
Sbjct: 1 MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE 60
Query: 65 QRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTC 124
RT++ C+V Q+NWL+T++V R AQ+ ++ L F++R C+S+ + GTC
Sbjct: 61 HYTPIRTYQVCNVMDH----SQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTC 116
Query: 125 RETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPH 184
+ETF LYY ++++ D + ++TK+DTIAADESF
Sbjct: 117 KETFNLYYMESDD----DHGVKFREHQFTKIDTIAADESFTQMD---------------- 156
Query: 185 GAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPE 244
G R L+LN + R GP+ ++GFY+AFQD GAC+ALV+VR++ CP +++ A FP+
Sbjct: 157 -LGDRI-LKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPD 214
Query: 245 TQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPG 304
T + SLV G+CV +++ E+ PPR++C+ EG+W+V +G C C G
Sbjct: 215 TVPMDS--QSLVEVRGSCVNNSKEED----------PPRMYCSTEGEWLVPIGKCSCNAG 262
Query: 305 YQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEA 364
Y+ RG CQAC G YK+ GN C+ CP S + C C ++RA DPP
Sbjct: 263 YEE-RGFM-CQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSM 320
Query: 365 PCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTC 424
CT PPS+P+ + + ++++L W P + GGR D+ FN++CK+C + C
Sbjct: 321 ACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQ-------C 373
Query: 425 HRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTS 484
C V F PRQ GLT + V V L AH Y E+ AVNGVSELS P Q AA++++T+
Sbjct: 374 EPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTN 433
Query: 485 HEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNT 544
PS V + + + NSI++SW +P+ NG ILDY+++YY++ E E+ L +
Sbjct: 434 QAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTN 493
Query: 545 ATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLP 581
T++ L P IY FQ+RARTAAG+G K F+T P
Sbjct: 494 VTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSP 530
>gi|55770892 ephrin receptor EphA8 isoform 2 precursor [Homo
sapiens]
Length = 495
Score = 337 bits (863), Expect = 4e-92
Identities = 181/472 (38%), Positives = 269/472 (56%), Gaps = 52/472 (11%)
Query: 19 SLWVLLLVSSVLAL------EEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTF 72
+LWV+ ++ E LLDT+ + GWLTYP GWD ++ +D+ + T+
Sbjct: 11 ALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQPIHTY 70
Query: 73 EACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYY 132
+ C+V Q+NWL+T +V R GA+R + + F++R C+S+ GTC+ETF LYY
Sbjct: 71 QVCNVMSP----NQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYY 126
Query: 133 RQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGL 192
+++ D +S ++ K+DTIAADESF + G R L
Sbjct: 127 LESDR----DLGASTQESQFLKIDTIAADESFTGAD-----------------LGVRR-L 164
Query: 193 QLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGG 252
+LN + RS GPL++RGFY+AFQD GACLA++++R++ CPA++R+ A+F E +GA
Sbjct: 165 KLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEA-VTGADS 223
Query: 253 ASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDK 312
+SLV G CV H+E + P+++C+ EG+W+V +G C C GY+ R
Sbjct: 224 SSLVEVRGQCVRHSEERDT----------PKMYCSAEGEWLVPIGKCVCSAGYEERRD-- 271
Query: 313 ACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSA 372
AC AC G YKS+ G+ C+ CP SH+ PAA C C +YRA+ DPP + CT PPSA
Sbjct: 272 ACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSACTRPPSA 331
Query: 373 PQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVH 432
P L V G+++ L W P + GGR D+ +N VC+ C C C
Sbjct: 332 PVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWAL-------SRCEACGSGTR 384
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTS 484
F P+Q L ++ +LV L AH+ Y ++AVNGVS+LSP+P +AA +N++T+
Sbjct: 385 FVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTN 436
>gi|150456469 EPH receptor A10 isoform 2 [Homo sapiens]
Length = 295
Score = 209 bits (533), Expect = 8e-54
Identities = 117/281 (41%), Positives = 161/281 (57%), Gaps = 33/281 (11%)
Query: 31 ALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWL 90
A E +LLD+ +E+GW P GW+E+S +D+ R RT++ C+V QDNWL
Sbjct: 33 AEEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEP----NQDNWL 88
Query: 91 QTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLK 150
QT ++ R QR + L F++R CSS+ + GTC+ETF +YY + E D
Sbjct: 89 QTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEA-DLGRGRPRLGGS 147
Query: 151 RWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFY 210
R K+DTIAADESF G+R ++LN + R GPL++RGF+
Sbjct: 148 RPRKIDTIAADESFTQGD-----------------LGERK-MKLNTEVREIGPLSRRGFH 189
Query: 211 VAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEE 270
+AFQD GAC+ALV+VR++ C A +R A+FP T A A ++LV GTCVAH+E E
Sbjct: 190 LAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESA-FSTLVEVAGTCVAHSEGEP 248
Query: 271 DGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGD 311
GSPPR+HC +G+W+V VG C C G+Q RGD
Sbjct: 249 --------GSPPRMHCGADGEWLVPVGRCSCSAGFQ-ERGD 280
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 185 bits (469), Expect = 2e-46
Identities = 145/512 (28%), Positives = 242/512 (47%), Gaps = 55/512 (10%)
Query: 435 PRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQ-----AAAINVSTSHEVPS 489
P ++ + + +++ GLR Y +E+QA N D P+ AA ++ T E +
Sbjct: 785 PFEKVVNKESLVISGLRHFTGYRIELQACN------QDTPEERCSVAAYVSARTMPEAKA 838
Query: 490 ---AVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSE---TN 543
PV H++ +N + + W +P + NG I+ Y++ Y ++E H
Sbjct: 839 DDIVGPVTHEIFE-NNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 897
Query: 544 TATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGA 603
+ LSPG+ Y ++RA + AG+G + YF ++ S + + I+G
Sbjct: 898 GCRLRGLSPGN-YSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAK-------IIIGP 949
Query: 604 LAFLLLAAITVLAV-VFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELA 662
L F+ L ++ + ++ +F RKR+ G L S+P Y+ S PC
Sbjct: 950 LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE-----YLSASDVF-PCSVYVPDE 1003
Query: 663 REVDPAYIKIEEVIGTGSFGEVRQGRLQP--RGRREQTVAIQALWAGGAESLQMTFLGRA 720
EV I + +G GSFG V +G + +G E VA++ + + ++ FL A
Sbjct: 1004 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 1063
Query: 721 AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSS---------LQ 771
+V+ F +++RL GVV+K +P +V+ E M G L S+LR + + +
Sbjct: 1064 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 1123
Query: 772 LVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG---------HSPQGPS 822
++ M +A M YL++ FVHR L+A + +V K+ G + +G
Sbjct: 1124 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGK 1183
Query: 823 CLL--RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRL 880
LL RW APE + G TTSSD+WSFG+++WE+ S E+PY +S ++VL + L
Sbjct: 1184 GLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYL 1243
Query: 881 PPPPGCPPGLHLLMLDTWQKDRARRPHFDQLV 912
P CP + LM WQ + RP F ++V
Sbjct: 1244 DQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1275
Score = 35.0 bits (79), Expect = 0.36
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 1/87 (1%)
Query: 446 LVGGLRAHVPYILEVQAVNGVS-ELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSI 504
L+ GL+ Y + V+ + S E ++ I V T PS VS +S+ I
Sbjct: 579 LMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQI 638
Query: 505 TVSWPQPDQTNGNILDYQLRYYDQAED 531
+ W P NGNI Y + + QAED
Sbjct: 639 ILKWKPPSDPNGNITHYLVFWERQAED 665
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 185 bits (469), Expect = 2e-46
Identities = 145/512 (28%), Positives = 242/512 (47%), Gaps = 55/512 (10%)
Query: 435 PRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQ-----AAAINVSTSHEVPS 489
P ++ + + +++ GLR Y +E+QA N D P+ AA ++ T E +
Sbjct: 797 PFEKVVNKESLVISGLRHFTGYRIELQACN------QDTPEERCSVAAYVSARTMPEAKA 850
Query: 490 ---AVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSE---TN 543
PV H++ +N + + W +P + NG I+ Y++ Y ++E H
Sbjct: 851 DDIVGPVTHEIFE-NNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 909
Query: 544 TATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGA 603
+ LSPG+ Y ++RA + AG+G + YF ++ S + + I+G
Sbjct: 910 GCRLRGLSPGN-YSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAK-------IIIGP 961
Query: 604 LAFLLLAAITVLAV-VFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELA 662
L F+ L ++ + ++ +F RKR+ G L S+P Y+ S PC
Sbjct: 962 LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE-----YLSASDVF-PCSVYVPDE 1015
Query: 663 REVDPAYIKIEEVIGTGSFGEVRQGRLQP--RGRREQTVAIQALWAGGAESLQMTFLGRA 720
EV I + +G GSFG V +G + +G E VA++ + + ++ FL A
Sbjct: 1016 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 1075
Query: 721 AVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSS---------LQ 771
+V+ F +++RL GVV+K +P +V+ E M G L S+LR + + +
Sbjct: 1076 SVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 1135
Query: 772 LVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG---------HSPQGPS 822
++ M +A M YL++ FVHR L+A + +V K+ G + +G
Sbjct: 1136 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGK 1195
Query: 823 CLL--RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRL 880
LL RW APE + G TTSSD+WSFG+++WE+ S E+PY +S ++VL + L
Sbjct: 1196 GLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYL 1255
Query: 881 PPPPGCPPGLHLLMLDTWQKDRARRPHFDQLV 912
P CP + LM WQ + RP F ++V
Sbjct: 1256 DQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1287
Score = 35.0 bits (79), Expect = 0.36
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 1/87 (1%)
Query: 446 LVGGLRAHVPYILEVQAVNGVS-ELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSI 504
L+ GL+ Y + V+ + S E ++ I V T PS VS +S+ I
Sbjct: 579 LMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQI 638
Query: 505 TVSWPQPDQTNGNILDYQLRYYDQAED 531
+ W P NGNI Y + + QAED
Sbjct: 639 ILKWKPPSDPNGNITHYLVFWERQAED 665
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 177 bits (450), Expect = 3e-44
Identities = 136/501 (27%), Positives = 235/501 (46%), Gaps = 48/501 (9%)
Query: 442 ESRVLVGGLRAHVPYILEVQAVNGVSEL----SPDPPQAAAINVSTSHEVPSAVPVVHQV 497
+ R ++ LR Y +++ + N +E + + A + + ++P PV +
Sbjct: 785 KERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPG--PVTWE- 841
Query: 498 SRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTS--ETNTATVTQLSPGHI 555
R NSI + WP+P+ NG IL Y+++Y Q ED+ + + A + +L+PG+
Sbjct: 842 PRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN- 900
Query: 556 YGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVL 615
Y +++A + +G+G + V+F + + + L+I L L++ + ++
Sbjct: 901 YTARIQATSLSGNGSWTDPVFFYV----QAKTGYENFIHLIIA--LPVAVLLIVGGLVIM 954
Query: 616 AVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEV 675
VF RKR S G GV Y Y EV I +
Sbjct: 955 LYVFHRKRNN----------SRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRE 1004
Query: 676 IGTGSFGEVRQGRLQP--RGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILR 733
+G GSFG V +G + + E VAI+ + + ++ FL A+V+ +F +++R
Sbjct: 1005 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVR 1064
Query: 734 LEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQF---------SSLQLVAMQRGVAAAMQ 784
L GVV++ +P +V+ E M G L S+LR + S +++ M +A M
Sbjct: 1065 LLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMA 1124
Query: 785 YLSSFAFVHRSLSAHSVLVNSHLVCKVARLG---------HSPQGPSCLL--RWAAPEVI 833
YL++ FVHR L+A + +V K+ G + +G LL RW +PE +
Sbjct: 1125 YLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 1184
Query: 834 AHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLL 893
G TT SDVWSFG+++WE+ + E+PY +S ++VL + + L P CP L L
Sbjct: 1185 KDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFEL 1244
Query: 894 MLDTWQKDRARRPHFDQLVAA 914
M WQ + RP F +++++
Sbjct: 1245 MRMCWQYNPKMRPSFLEIISS 1265
Score = 40.0 bits (92), Expect = 0.011
Identities = 38/151 (25%), Positives = 63/151 (41%), Gaps = 5/151 (3%)
Query: 385 LMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTC-HRCRDEVHFDPRQRGLTES 443
+++ W R R + F V KE + G C + V D E
Sbjct: 505 IIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEP 564
Query: 444 RVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAA---INVSTSHEVPSAVPVVHQVSRA 500
+L+ GL+ Y + V+AV ++ + D + A + + T+ VPS V S +
Sbjct: 565 GILLHGLKPWTQYAVYVKAVT-LTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS 623
Query: 501 SNSITVSWPQPDQTNGNILDYQLRYYDQAED 531
S+ + V W P NGN+ Y +R+ Q +D
Sbjct: 624 SSQLIVKWNPPSLPNGNLSYYIVRWQRQPQD 654
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 167 bits (422), Expect = 6e-41
Identities = 108/291 (37%), Positives = 158/291 (54%), Gaps = 25/291 (8%)
Query: 657 AIRELARE---VDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQ 713
A ELAR ++ ++ + IG G FG V QG Q VA++ + +
Sbjct: 178 AEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG-----QKVAVKNI---KCDVTA 229
Query: 714 MTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQR-EGQFSSLQL 772
FL AV+ + QH N++RL GV+ + L ++ E + G L +FLR R ++ QL
Sbjct: 230 QAFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQL 288
Query: 773 VAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCL------LR 826
+ VA M+YL S VHR L+A ++LV+ LV KV+ G + L ++
Sbjct: 289 LQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK 348
Query: 827 WAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGC 886
W APE + HGK T+ SDVWSFG+L+WEV SYG PY MS +EV A+E+ +R+ PP GC
Sbjct: 349 WTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGC 408
Query: 887 PPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQ 937
P +H+LM W+ + ARRP F +L +K+ R+ L++ G P Q
Sbjct: 409 PGPVHVLMSSCWEAEPARRPPFRKLA---EKLARE---LRSAGAPASVSGQ 453
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 167 bits (422), Expect = 6e-41
Identities = 108/291 (37%), Positives = 158/291 (54%), Gaps = 25/291 (8%)
Query: 657 AIRELARE---VDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQ 713
A ELAR ++ ++ + IG G FG V QG Q VA++ + +
Sbjct: 220 AEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG-----QKVAVKNI---KCDVTA 271
Query: 714 MTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQR-EGQFSSLQL 772
FL AV+ + QH N++RL GV+ + L ++ E + G L +FLR R ++ QL
Sbjct: 272 QAFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQL 330
Query: 773 VAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCL------LR 826
+ VA M+YL S VHR L+A ++LV+ LV KV+ G + L ++
Sbjct: 331 LQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK 390
Query: 827 WAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGC 886
W APE + HGK T+ SDVWSFG+L+WEV SYG PY MS +EV A+E+ +R+ PP GC
Sbjct: 391 WTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGC 450
Query: 887 PPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQ 937
P +H+LM W+ + ARRP F +L +K+ R+ L++ G P Q
Sbjct: 451 PGPVHVLMSSCWEAEPARRPPFRKLA---EKLARE---LRSAGAPASVSGQ 495
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 167 bits (422), Expect = 6e-41
Identities = 108/291 (37%), Positives = 158/291 (54%), Gaps = 25/291 (8%)
Query: 657 AIRELARE---VDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQ 713
A ELAR ++ ++ + IG G FG V QG Q VA++ + +
Sbjct: 219 AEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG-----QKVAVKNI---KCDVTA 270
Query: 714 MTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQR-EGQFSSLQL 772
FL AV+ + QH N++RL GV+ + L ++ E + G L +FLR R ++ QL
Sbjct: 271 QAFLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQL 329
Query: 773 VAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCL------LR 826
+ VA M+YL S VHR L+A ++LV+ LV KV+ G + L ++
Sbjct: 330 LQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVK 389
Query: 827 WAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGC 886
W APE + HGK T+ SDVWSFG+L+WEV SYG PY MS +EV A+E+ +R+ PP GC
Sbjct: 390 WTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGC 449
Query: 887 PPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQ 937
P +H+LM W+ + ARRP F +L +K+ R+ L++ G P Q
Sbjct: 450 PGPVHVLMSSCWEAEPARRPPFRKLA---EKLARE---LRSAGAPASVSGQ 494
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 166 bits (421), Expect = 8e-41
Identities = 164/635 (25%), Positives = 267/635 (42%), Gaps = 71/635 (11%)
Query: 317 CPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQEL 376
C RGL ++ N P + CPC PP PP QE
Sbjct: 657 CHRGLRLPTSNNDPRFDGEDGDPEAEMESDCCPC--------QHPPPGQVL-PPLEAQEA 707
Query: 377 WFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASG----GGGTCHRCRDEVH 432
F+ + LH + + N + GR A+G GG +
Sbjct: 708 SFQKKFENF-LHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSD------- 759
Query: 433 FDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVP 492
F+ ++ + R ++ GLR Y +++ A N + + H +P
Sbjct: 760 FEIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIP 819
Query: 493 -VVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESH---SFTLTSETNTATVT 548
V + + NS+ + W +P NG IL Y+++Y E+ + S ++ +
Sbjct: 820 GKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLA 879
Query: 549 QLSPGHIYGFQVRARTAAGHGPYGGKVYFQTL-PQGELSSQLPERLSLVIGSILGALAFL 607
L PG+ Y +VRA + AG+G + V F L P+ E + L L+ +
Sbjct: 880 LLPPGN-YSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTAT------PVGLT 932
Query: 608 LLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDP 667
LL + L + +KR T Y +Y S Y+ P +E P + I + RE
Sbjct: 933 LLIVLAALGFFYGKKRNRTLYASVNPEYFSAS---DMYV-PDEWEVPREQI-SIIRE--- 984
Query: 668 AYIKIEEVIGTGSFGEVRQG--RLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQ 725
+G GSFG V +G R G VA++ + + + FL A+V+
Sbjct: 985 --------LGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKA 1036
Query: 726 FQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSL---------QLVAMQ 776
F+ +++RL GVV++ +P +V+ E M G L S LR + + +++ M
Sbjct: 1037 FKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMA 1096
Query: 777 RGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG---------HSPQGPSCLL-- 825
+A M YL++ FVHR L+A + +V+ K+ G + +G LL
Sbjct: 1097 GEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPV 1156
Query: 826 RWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPG 885
RW APE + G TT SDVWSFG+++WE+++ E+PY +S ++VL + L G
Sbjct: 1157 RWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEG 1216
Query: 886 CPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIR 920
CP L LM WQ + RP F ++ + + +R
Sbjct: 1217 CPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELR 1251
Score = 38.9 bits (89), Expect = 0.025
Identities = 39/155 (25%), Positives = 60/155 (38%), Gaps = 5/155 (3%)
Query: 381 QGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCH-RCRDEVHFDPRQRG 439
+ ++L W L R L F V KE + G C + + + +
Sbjct: 495 EADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSR 554
Query: 440 LTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSR 499
E V + L+ Y + V+A+ +E P Q A + +P+A V V
Sbjct: 555 TQEPGVTLASLKPWTQYAVFVRAITLTTE-EDSPHQGAQSPIVYLRTLPAAPTVPQDVIS 613
Query: 500 ASNS---ITVSWPQPDQTNGNILDYQLRYYDQAED 531
SNS + V W P Q NGN+ Y + + AED
Sbjct: 614 TSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAED 648
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 164 bits (414), Expect = 5e-40
Identities = 96/290 (33%), Positives = 149/290 (51%), Gaps = 15/290 (5%)
Query: 647 DPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWA 706
+ TY P E+ RE I++ IG G FG+V QG VAI+
Sbjct: 425 EEDTYTMPSTRDYEIQRE----RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 480
Query: 707 GGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQ 766
++S++ FL A + QF HP+I++L GV+T++ P+ ++ E LG L SFL+ R+
Sbjct: 481 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYS 539
Query: 767 FSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG----------H 816
L+ ++ A+ YL S FVHR ++A +VLV+S+ K+ G +
Sbjct: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 599
Query: 817 SPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQ 876
++W APE I + T++SDVW FG+ MWE++ +G +P+ + +V+ IE
Sbjct: 600 KASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN 659
Query: 877 EFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQ 926
RLP PP CPP L+ LM W D +RRP F +L A ++ + Q
Sbjct: 660 GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQ 709
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 164 bits (414), Expect = 5e-40
Identities = 96/290 (33%), Positives = 149/290 (51%), Gaps = 15/290 (5%)
Query: 647 DPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWA 706
+ TY P E+ RE I++ IG G FG+V QG VAI+
Sbjct: 403 EEDTYTMPSTRDYEIQRE----RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKN 458
Query: 707 GGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQ 766
++S++ FL A + QF HP+I++L GV+T++ P+ ++ E LG L SFL+ R+
Sbjct: 459 CTSDSVREKFLQEALTMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRKYS 517
Query: 767 FSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG----------H 816
L+ ++ A+ YL S FVHR ++A +VLV+S+ K+ G +
Sbjct: 518 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 577
Query: 817 SPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQ 876
++W APE I + T++SDVW FG+ MWE++ +G +P+ + +V+ IE
Sbjct: 578 KASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN 637
Query: 877 EFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQ 926
RLP PP CPP L+ LM W D +RRP F +L A ++ + Q
Sbjct: 638 GERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQ 687
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 162 bits (409), Expect = 2e-39
Identities = 100/275 (36%), Positives = 148/275 (53%), Gaps = 18/275 (6%)
Query: 650 TYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGA 709
T + Q + + A E+ +++E +G G FGEV G R VAI+ L G
Sbjct: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTM 305
Query: 710 ESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSS 769
FL A V+ + +H +++L VV++ P+ ++TE+M G L FL+ G++
Sbjct: 306 SP--EAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLR 362
Query: 770 L-QLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG----------HSP 818
L QLV M +A+ M Y+ +VHR L A ++LV +LVCKVA G +
Sbjct: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422
Query: 819 QGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEF 878
QG ++W APE +G+ T SDVWSFGIL+ E+ + G PY M +EVL+ +E+ +
Sbjct: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482
Query: 879 RLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVA 913
R+P PP CP LH LM W+K+ RP F+ L A
Sbjct: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA 517
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 162 bits (409), Expect = 2e-39
Identities = 100/275 (36%), Positives = 148/275 (53%), Gaps = 18/275 (6%)
Query: 650 TYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGA 709
T + Q + + A E+ +++E +G G FGEV G R VAI+ L G
Sbjct: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTM 305
Query: 710 ESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSS 769
FL A V+ + +H +++L VV++ P+ ++TE+M G L FL+ G++
Sbjct: 306 SP--EAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLR 362
Query: 770 L-QLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLG----------HSP 818
L QLV M +A+ M Y+ +VHR L A ++LV +LVCKVA G +
Sbjct: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422
Query: 819 QGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEF 878
QG ++W APE +G+ T SDVWSFGIL+ E+ + G PY M +EVL+ +E+ +
Sbjct: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482
Query: 879 RLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVA 913
R+P PP CP LH LM W+K+ RP F+ L A
Sbjct: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA 517
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,910,568
Number of Sequences: 37866
Number of extensions: 2403889
Number of successful extensions: 13097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 326
Number of HSP's successfully gapped in prelim test: 603
Number of HSP's that attempted gapping in prelim test: 10346
Number of HSP's gapped (non-prelim): 2269
length of query: 1021
length of database: 18,247,518
effective HSP length: 112
effective length of query: 909
effective length of database: 14,006,526
effective search space: 12731932134
effective search space used: 12731932134
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.