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Search of human proteins with 19224660
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19224660 protein kinase C and casein kinase substrate in
neurons 3 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19224660 protein kinase C and casein kinase substrate in neur... 872 0.0
gi|148747351 protein kinase C and casein kinase substrate in neu... 493 e-139
gi|24308229 protein kinase C and casein kinase substrate in neur... 477 e-135
gi|20149528 proline-serine-threonine phosphatase interacting pro... 99 9e-21
gi|165905601 proline-serine-threonine phosphatase interacting pr... 62 1e-09
gi|27544941 myosin IF [Homo sapiens] 60 4e-09
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 60 5e-09
gi|115527120 nebulin [Homo sapiens] 59 1e-08
gi|239049457 FCH domain only 1 isoform b [Homo sapiens] 57 2e-08
gi|29789054 FCH domain only 1 isoform b [Homo sapiens] 57 2e-08
gi|239049440 FCH domain only 1 isoform a [Homo sapiens] 57 2e-08
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 55 1e-07
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 55 1e-07
gi|23397574 sorting nexin 33 [Homo sapiens] 55 1e-07
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 53 5e-07
gi|153792195 DKFZP434H0735 protein [Homo sapiens] 53 5e-07
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 53 5e-07
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 53 5e-07
gi|191252814 RIMS binding protein 3B [Homo sapiens] 52 8e-07
gi|191252806 RIMS binding protein 3C [Homo sapiens] 52 8e-07
gi|109689723 abl interactor 2 [Homo sapiens] 52 1e-06
gi|208022687 GTPase regulator associated with the focal adhesion... 52 1e-06
gi|55956916 myosin IE [Homo sapiens] 52 1e-06
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 52 1e-06
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 52 1e-06
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 52 1e-06
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 51 2e-06
gi|226371723 FCH domain only 2 isoform a [Homo sapiens] 51 2e-06
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 50 3e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 50 3e-06
>gi|19224660 protein kinase C and casein kinase substrate in neurons
3 [Homo sapiens]
Length = 424
Score = 872 bits (2253), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW 60
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW
Sbjct: 1 MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW 60
Query: 61 ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR 120
ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR
Sbjct: 61 ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR 120
Query: 121 PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV 180
PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV
Sbjct: 121 PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV 180
Query: 181 SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL 240
SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL
Sbjct: 181 SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL 240
Query: 241 FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE 300
FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE
Sbjct: 241 FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE 300
Query: 301 EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPR 360
EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPR
Sbjct: 301 EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPR 360
Query: 361 KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE
Sbjct: 361 KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
Query: 421 CVGA 424
CVGA
Sbjct: 421 CVGA 424
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 493 bits (1270), Expect = e-139
Identities = 244/481 (50%), Positives = 323/481 (67%), Gaps = 63/481 (13%)
Query: 4 EEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARK 63
++ G E SFWE GNY+RTV+R++DGHRLC DL++C ERARIEKAYAQQL +WAR+
Sbjct: 6 DDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARR 65
Query: 64 WRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVL 123
WR VEKGPQYGT+EKAW AF + AER+S LHLEV+ L D E+++ WQ+ AFH+ ++
Sbjct: 66 WRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMM 125
Query: 124 GGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQE 183
GGF+E++ AEDGFRKAQKPW K+LKEVEA+KK++HAA K+EK A +RE+++KAD +++ E
Sbjct: 126 GGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPE 185
Query: 184 QLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFK 243
QL+KLQ+++E+C ++ KTK +YE++L EL + TP+YME+MEQ FE CQ E +RL FF+
Sbjct: 186 QLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFR 245
Query: 244 DMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWS 303
++LL + +HLDLS+ + ++ DL Q I AA EDLRW+R+ HGPGMAMNWPQFEEWS
Sbjct: 246 EVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEEWS 305
Query: 304 LDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPP--------PQSPGSPGTGQDE---- 351
D RT+SR+EK ++ D VTLT I T D + P P +P Q
Sbjct: 306 ADLNRTLSRREK-KKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSSYNPF 364
Query: 352 --------------------------------EWSDEES------------------PRK 361
+WSD+ES
Sbjct: 365 EDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDAT 424
Query: 362 AATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVEC 421
+ T VRVRALYDY GQE DELSF+AG+EL KM +EDEQGWC+G+L +G++GLYPANYVE
Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEA 484
Query: 422 V 422
+
Sbjct: 485 I 485
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 477 bits (1228), Expect = e-135
Identities = 227/441 (51%), Positives = 314/441 (71%), Gaps = 25/441 (5%)
Query: 1 MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW 60
+APEE SFWE GNY+RTV+R++DGHRLC DL++C QERA+IEKAY QQL DW
Sbjct: 10 LAPEETTD------SFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDW 63
Query: 61 ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR 120
A++WR +EKGPQYG+LE+AW A T A+++S LH EV+ L +D E+V+ WQ+ A+H+
Sbjct: 64 AKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHK 123
Query: 121 PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV 180
++GGF+E++ AEDGFRKAQKPW K++KE+EA+KK+YH A K+EK A TRE ++K + +V
Sbjct: 124 QIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSV 183
Query: 181 SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL 240
+ EQ +KLQ++V++C ++ +KT+ +YE+ L ++ + TP+YME+MEQ FE CQ E +RL+
Sbjct: 184 TPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLV 243
Query: 241 FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE 300
F K++LL + +HL+L+ + + ++R+L Q I A +EDLRW+RST GPGM MNWPQFE
Sbjct: 244 FLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFE 303
Query: 301 EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGT--APPPQSPGSPGTGQD--EEWSDE 356
EW+ D T ++KEK + + V LT+ + T A S S GQ EWSD+
Sbjct: 304 EWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDD 363
Query: 357 ESP---------------RKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGW 401
ES + GVRVRALYDY GQE DELSF+AG+EL K+ EEDEQGW
Sbjct: 364 ESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGW 423
Query: 402 CQGQLQSGRIGLYPANYVECV 422
C+G+L SG++GLYPANYVE +
Sbjct: 424 CRGRLDSGQLGLYPANYVEAI 444
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 98.6 bits (244), Expect = 9e-21
Identities = 95/418 (22%), Positives = 171/418 (40%), Gaps = 44/418 (10%)
Query: 22 YRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGPQYGTLEKAW 81
Y +QR+ DG ++C D+ ++RA+ E+ Y ++L ARK G E +L ++
Sbjct: 22 YEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTE----INSLRASF 77
Query: 82 HAFFTAAERLSALHLEV----REKLQGQDSERVRAWQRGAFHRPVLGGFRESRAAEDGFR 137
+ E + + H+++ RE+L+ + R R ++ + V+
Sbjct: 78 DSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMD------------- 124
Query: 138 KAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAK 197
+ QK L K+ SKK+Y +D A+ A+ Q+Q+ K Q + +C
Sbjct: 125 RVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANG--HQKQVEKSQNKARQCKD 182
Query: 198 EAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSS 257
A + + Y Q++A+L + + ++ E Q E RL ++ L L +
Sbjct: 183 SATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQC 242
Query: 258 SEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGG 317
K EL+ ++ +E S + D+ + G P + D + T G
Sbjct: 243 V-KDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGI 301
Query: 318 R---------------SPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKA 362
+ SP +L + + + P P+ T + E A
Sbjct: 302 QPSCGMIKRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQ---EIQGNPA 358
Query: 363 ATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
+ RALYDY Q DEL AG ++L++ E E GW + ++G+ G P +Y+E
Sbjct: 359 SPAQEYRALYDYTAQNPDELDLSAG-DILEVILEGEDGWWTVE-RNGQRGFVPGSYLE 414
>gi|165905601 proline-serine-threonine phosphatase interacting
protein 2 [Homo sapiens]
Length = 334
Score = 62.0 bits (149), Expect = 1e-09
Identities = 67/347 (19%), Positives = 141/347 (40%), Gaps = 30/347 (8%)
Query: 14 GSFWEAG-----NYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTV 68
G+FW A Y +Q + +G + C + +ERA IE+ Y + L + +RK
Sbjct: 8 GNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRK---KP 64
Query: 69 EKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRE 128
+ TL++A F + ++ H+++ + L+ + + ++ R ++
Sbjct: 65 CGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQR------KK 118
Query: 129 SRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKL 188
+ D K + K+ + +KK+Y +D+ A+ ++ +++ + V+ +Q KL
Sbjct: 119 TELIMDAIHKQKSLQFKKTMD---AKKNYEQKCRDKDEAE--QAVSRSANLVNPKQQEKL 173
Query: 189 QERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLT 248
++ E + Y + L + + + +A E +A E +R+ FF++ L
Sbjct: 174 FVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRN-ALW 232
Query: 249 LHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQR 308
LH + E++ + + +E S + D+ ++ + G P E +Q+
Sbjct: 233 LHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQK 292
Query: 309 TISRKEKGGRSPDEVTLTSIVPTRDGTAP-PPQSPGSPGTGQDEEWS 354
K T R G P P SP P +++S
Sbjct: 293 NAVPAGKA---------TGPNLARRGPLPIPKSSPDDPNYSLVDDYS 330
>gi|27544941 myosin IF [Homo sapiens]
Length = 1098
Score = 60.1 bits (144), Expect = 4e-09
Identities = 33/76 (43%), Positives = 45/76 (59%), Gaps = 9/76 (11%)
Query: 345 PGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQG 404
PG G+ + P+ G R RALY Y GQ+ DELSF E++++ ED GW +G
Sbjct: 1030 PGVGRPK-------PQPRTHGPRCRALYQYVGQDVDELSFNV-NEVIEILMEDPSGWWKG 1081
Query: 405 QLQSGRIGLYPANYVE 420
+L G+ GL+P NYVE
Sbjct: 1082 RLH-GQEGLFPGNYVE 1096
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 59.7 bits (143), Expect = 5e-09
Identities = 52/194 (26%), Positives = 93/194 (47%), Gaps = 22/194 (11%)
Query: 247 LTLHQHLDLSSSEKF-HELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWS-- 303
L L Q +L S ++ E ++ +G +D +L+ + T + + + E S
Sbjct: 72 LRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRM 131
Query: 304 -------LDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAP----PPQSPGSPGTGQDEE 352
++ +R S+ R P E +PT +AP P Q P + G +E
Sbjct: 132 GPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPT---SAPVYQQPQQQPVAQSYGGYKE 188
Query: 353 WSDEESPRKAATG---VRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQ-S 408
+ S +++A G R RA+YDY+ + DE+SF+ G+ ++ + + D+ GW G ++ +
Sbjct: 189 PAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDD-GWMYGTVERT 247
Query: 409 GRIGLYPANYVECV 422
G G+ PANYVE +
Sbjct: 248 GDTGMLPANYVEAI 261
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 58.5 bits (140), Expect = 1e-08
Identities = 36/89 (40%), Positives = 48/89 (53%), Gaps = 4/89 (4%)
Query: 335 TAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMS 394
T P Q S T Q S P A G RA+YDY +ADE+SF+ G+ ++ +
Sbjct: 6584 TELPQQRSSSVATQQTTVSSIPSHPSTA--GKIFRAMYDYMAADADEVSFKDGDAIINVQ 6641
Query: 395 EEDEQGWCQGQLQ-SGRIGLYPANYVECV 422
DE GW G +Q +GR G+ PANYVE +
Sbjct: 6642 AIDE-GWMYGTVQRTGRTGMLPANYVEAI 6669
>gi|239049457 FCH domain only 1 isoform b [Homo sapiens]
Length = 889
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/379 (21%), Positives = 143/379 (37%), Gaps = 57/379 (15%)
Query: 13 GGSFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEK 70
G FW N+ V V+ G +L +ERA IE+ Y++ +A ++
Sbjct: 5 GEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSK----LASN 60
Query: 71 GPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESR 130
G GT W F ++++L+ HLE+ KLQ + +R + L ++ +
Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLR------YGEEQLKTHKKCK 114
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A + + + S+++Y D++ + RES ++ + ++ + +K E
Sbjct: 115 EEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLR-RESTSQKEMDKAETKTKKAAE 173
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
+ R ++ +A +EQ M D F QA E L K LL +
Sbjct: 174 SLRRSVEKYNSARADFEQK-----------MLDSALRF---QAMEETHLRHMK-ALLGSY 218
Query: 251 QHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWP-QFEEWSLDTQRT 309
H + + ++H + Q IE S E LR + + G G P FE +S +
Sbjct: 219 AHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQE 278
Query: 310 ISRKEKGG------------RSPDEVTLTSIVPTRDGTAPPPQSPG-------------- 343
++ +G R P+ + GT P G
Sbjct: 279 AMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAE 338
Query: 344 -SPGTGQDEEWSDEESPRK 361
S + D ++ DEE PRK
Sbjct: 339 PSRFSSSDSDFDDEE-PRK 356
>gi|29789054 FCH domain only 1 isoform b [Homo sapiens]
Length = 889
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/379 (21%), Positives = 143/379 (37%), Gaps = 57/379 (15%)
Query: 13 GGSFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEK 70
G FW N+ V V+ G +L +ERA IE+ Y++ +A ++
Sbjct: 5 GEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSK----LASN 60
Query: 71 GPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESR 130
G GT W F ++++L+ HLE+ KLQ + +R + L ++ +
Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLR------YGEEQLKTHKKCK 114
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A + + + S+++Y D++ + RES ++ + ++ + +K E
Sbjct: 115 EEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLR-RESTSQKEMDKAETKTKKAAE 173
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
+ R ++ +A +EQ M D F QA E L K LL +
Sbjct: 174 SLRRSVEKYNSARADFEQK-----------MLDSALRF---QAMEETHLRHMK-ALLGSY 218
Query: 251 QHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWP-QFEEWSLDTQRT 309
H + + ++H + Q IE S E LR + + G G P FE +S +
Sbjct: 219 AHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQE 278
Query: 310 ISRKEKGG------------RSPDEVTLTSIVPTRDGTAPPPQSPG-------------- 343
++ +G R P+ + GT P G
Sbjct: 279 AMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAE 338
Query: 344 -SPGTGQDEEWSDEESPRK 361
S + D ++ DEE PRK
Sbjct: 339 PSRFSSSDSDFDDEE-PRK 356
>gi|239049440 FCH domain only 1 isoform a [Homo sapiens]
Length = 891
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/379 (21%), Positives = 143/379 (37%), Gaps = 57/379 (15%)
Query: 13 GGSFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEK 70
G FW N+ V V+ G +L +ERA IE+ Y++ +A ++
Sbjct: 5 GEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSK----LASN 60
Query: 71 GPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESR 130
G GT W F ++++L+ HLE+ KLQ + +R + L ++ +
Sbjct: 61 GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLR------YGEEQLKTHKKCK 114
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A + + + S+++Y D++ + RES ++ + ++ + +K E
Sbjct: 115 EEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLR-RESTSQKEMDKAETKTKKAAE 173
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
+ R ++ +A +EQ M D F QA E L K LL +
Sbjct: 174 SLRRSVEKYNSARADFEQK-----------MLDSALRF---QAMEETHLRHMK-ALLGSY 218
Query: 251 QHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWP-QFEEWSLDTQRT 309
H + + ++H + Q IE S E LR + + G G P FE +S +
Sbjct: 219 AHSVEDTHVQIGQVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQE 278
Query: 310 ISRKEKGG------------RSPDEVTLTSIVPTRDGTAPPPQSPG-------------- 343
++ +G R P+ + GT P G
Sbjct: 279 AMKRLRGAKAFRLPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAE 338
Query: 344 -SPGTGQDEEWSDEESPRK 361
S + D ++ DEE PRK
Sbjct: 339 PSRFSSSDSDFDDEE-PRK 356
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 55.1 bits (131), Expect = 1e-07
Identities = 26/55 (47%), Positives = 39/55 (70%), Gaps = 2/55 (3%)
Query: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQ-SGRIGLYPANYVECV 422
RA+YDY+ Q+ DE+SFR G+ ++ + D+ GW G +Q +GR G+ PANY+E V
Sbjct: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDD-GWMYGTVQRTGRTGMLPANYIEFV 1013
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 26/55 (47%), Positives = 39/55 (70%), Gaps = 2/55 (3%)
Query: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQ-SGRIGLYPANYVECV 422
RA+YDY+ Q+ DE+SFR G+ ++ + D+ GW G +Q +GR G+ PANY+E V
Sbjct: 216 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDD-GWMYGTVQRTGRTGMLPANYIEFV 269
>gi|23397574 sorting nexin 33 [Homo sapiens]
Length = 574
Score = 55.1 bits (131), Expect = 1e-07
Identities = 25/54 (46%), Positives = 34/54 (62%)
Query: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
RALYD+ + +E+S + E+L+ SE GW QGQ G GL+PA+YVE V
Sbjct: 6 RALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIV 59
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 53.1 bits (126), Expect = 5e-07
Identities = 25/59 (42%), Positives = 36/59 (61%)
Query: 366 VRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA 424
+R RALYD+ + E+S R E L SE+D +GW +G G GL+PA+YV+ + A
Sbjct: 3 LRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRA 61
>gi|153792195 DKFZP434H0735 protein [Homo sapiens]
Length = 1639
Score = 53.1 bits (126), Expect = 5e-07
Identities = 70/306 (22%), Positives = 120/306 (39%), Gaps = 42/306 (13%)
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A E+G +A+ W++++ E E S+ H R Q R++ + Q+ R Q+
Sbjct: 616 AEENGRLQAKTDWVRKV-EAENSEVRGHLGR----ACQERDASGLIAEQLLQQAARG-QD 669
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
R ++ ++ +K + E+ R EQ +ET Q E Q
Sbjct: 670 RQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQ------------- 716
Query: 251 QHLDLSSSEKFH---------ELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEE 301
+ S KFH + +RD+ + EA+ +E + S P ++ P +
Sbjct: 717 --VKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQP 774
Query: 302 WSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRK 361
S ++T S+ T+ S TA E +P
Sbjct: 775 LS---KKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAP-- 829
Query: 362 AATGVRV-RALYDYAGQEAD------ELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLY 414
AA +++ A Y+Y E EL AG+ + + DE G+ +G+L+ GR GL
Sbjct: 830 AAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLV 889
Query: 415 PANYVE 420
P+N+VE
Sbjct: 890 PSNFVE 895
Score = 30.4 bits (67), Expect = 3.2
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 376 GQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
GQ L+ RAG+ ++ D+QG+ G+L G GL PA+ ++
Sbjct: 1589 GQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHLLD 1632
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 53.1 bits (126), Expect = 5e-07
Identities = 25/59 (42%), Positives = 36/59 (61%)
Query: 366 VRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA 424
+R RALYD+ + E+S R E L SE+D +GW +G G GL+PA+YV+ + A
Sbjct: 3 LRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRA 61
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 53.1 bits (126), Expect = 5e-07
Identities = 25/59 (42%), Positives = 36/59 (61%)
Query: 366 VRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA 424
+R RALYD+ + E+S R E L SE+D +GW +G G GL+PA+YV+ + A
Sbjct: 3 LRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRA 61
>gi|191252814 RIMS binding protein 3B [Homo sapiens]
Length = 1639
Score = 52.4 bits (124), Expect = 8e-07
Identities = 70/306 (22%), Positives = 119/306 (38%), Gaps = 42/306 (13%)
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A E+G +A+ W++++ E E S+ H R Q R++ + Q+ R Q+
Sbjct: 616 AEENGRLQAKTDWVRKV-EAENSEVRGHLGR----ACQERDASGLIAEQLLQQAARG-QD 669
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
R ++ ++ +K + E+ R EQ +ET Q E Q
Sbjct: 670 RQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQ------------- 716
Query: 251 QHLDLSSSEKFH---------ELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEE 301
+ S KFH + +RD+ + EA+ +E + S P ++ P +
Sbjct: 717 --VKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQP 774
Query: 302 WSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRK 361
S ++T S+ T+ S TA E +P
Sbjct: 775 LS---KKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAP-- 829
Query: 362 AATGVRV-RALYDYAGQEAD------ELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLY 414
AA +++ A Y+Y E EL AG+ + + DE G+ +G+L GR GL
Sbjct: 830 AAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLV 889
Query: 415 PANYVE 420
P+N+VE
Sbjct: 890 PSNFVE 895
Score = 30.4 bits (67), Expect = 3.2
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 376 GQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
GQ L+ RAG+ ++ D+QG+ G+L G GL PA+ ++
Sbjct: 1589 GQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHLLD 1632
>gi|191252806 RIMS binding protein 3C [Homo sapiens]
Length = 1639
Score = 52.4 bits (124), Expect = 8e-07
Identities = 70/306 (22%), Positives = 119/306 (38%), Gaps = 42/306 (13%)
Query: 131 AAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQE 190
A E+G +A+ W++++ E E S+ H R Q R++ + Q+ R Q+
Sbjct: 616 AEENGRLQAKTDWVRKV-EAENSEVRGHLGR----ACQERDASGLIAEQLLQQAARG-QD 669
Query: 191 RVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLH 250
R ++ ++ +K + E+ R EQ +ET Q E Q
Sbjct: 670 RQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQ------------- 716
Query: 251 QHLDLSSSEKFH---------ELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEE 301
+ S KFH + +RD+ + EA+ +E + S P ++ P +
Sbjct: 717 --VKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQP 774
Query: 302 WSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRK 361
S ++T S+ T+ S TA E +P
Sbjct: 775 LS---KKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAP-- 829
Query: 362 AATGVRV-RALYDYAGQEAD------ELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLY 414
AA +++ A Y+Y E EL AG+ + + DE G+ +G+L GR GL
Sbjct: 830 AAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLV 889
Query: 415 PANYVE 420
P+N+VE
Sbjct: 890 PSNFVE 895
Score = 30.4 bits (67), Expect = 3.2
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 376 GQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
GQ L+ RAG+ ++ D+QG+ G+L G GL PA+ ++
Sbjct: 1589 GQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHLLD 1632
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 330 PTRDGTAPPPQSPGSPGTGQDE--EWSD---EESPRKAATGV--RVRALYDYAGQEADEL 382
P D + PPP P + E+SD EE P A +V A+YDY + DEL
Sbjct: 373 PVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDEL 432
Query: 383 SFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
SF+ G ++ + ++++ GW +G + +G GL+P NYVE +
Sbjct: 433 SFQEG-AIIYVIKKNDDGWYEG-VMNGVTGLFPGNYVESI 470
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/107 (32%), Positives = 48/107 (44%), Gaps = 12/107 (11%)
Query: 325 LTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGV-----------RVRALYD 373
L + PTR + PP SP SP + +S SP ++ + +ALY
Sbjct: 652 LAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTPFRKAKALYA 711
Query: 374 YAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
+ ELSF AG + E GW +G L +G+ GL P NYVE
Sbjct: 712 CKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTL-NGKTGLIPENYVE 757
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 52.0 bits (123), Expect = 1e-06
Identities = 31/88 (35%), Positives = 47/88 (53%), Gaps = 12/88 (13%)
Query: 332 RDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELL 391
R T+ PP + G P + P+ + +ALY Y Q+ DELSF A +++
Sbjct: 1030 RQTTSRPPPAGGRP----------KPQPKPKPQVPQCKALYAYDAQDTDELSFNA-NDII 1078
Query: 392 KMSEEDEQGWCQGQLQSGRIGLYPANYV 419
+ +ED GW G+L+ G+ GL+P NYV
Sbjct: 1079 DIIKEDPSGWWTGRLR-GKQGLFPNNYV 1105
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 51.6 bits (122), Expect = 1e-06
Identities = 22/56 (39%), Positives = 38/56 (67%), Gaps = 2/56 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
G + +ALYD+ G+ DELSF+AG+ + ++ D+ W G+L G+ G++P NY++
Sbjct: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQ 726
Score = 46.2 bits (108), Expect = 6e-05
Identities = 23/58 (39%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
G R A ++Y G++ DELSF G E++ + E + W +G+++ GR G++P N+VE V
Sbjct: 514 GSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEVR-GRTGIFPLNFVEPV 569
Score = 39.7 bits (91), Expect = 0.005
Identities = 18/50 (36%), Positives = 34/50 (68%), Gaps = 2/50 (4%)
Query: 370 ALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYV 419
AL+ + + +D+LSF+ G+ +++ E + WC+G+LQ R G++PA +V
Sbjct: 609 ALHSFTAETSDDLSFKRGDR-IQILERLDSDWCRGRLQD-REGIFPAVFV 656
Score = 37.7 bits (86), Expect = 0.020
Identities = 16/52 (30%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 371 LYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
L+D+ ++ D+L+ +GE ++ + E+ + W +G ++ +IG++PANYV+ +
Sbjct: 444 LHDFPAEQVDDLNLTSGE-IVYLLEKIDTDWYRGNCRN-QIGIFPANYVKVI 493
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 51.6 bits (122), Expect = 1e-06
Identities = 22/56 (39%), Positives = 38/56 (67%), Gaps = 2/56 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
G + +ALYD+ G+ DELSF+AG+ + ++ D+ W G+L G+ G++P NY++
Sbjct: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQ 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 23/58 (39%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
G R A ++Y G++ DELSF G E++ + E + W +G+++ GR G++P N+VE V
Sbjct: 550 GSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEVR-GRTGIFPLNFVEPV 605
Score = 39.7 bits (91), Expect = 0.005
Identities = 18/50 (36%), Positives = 34/50 (68%), Gaps = 2/50 (4%)
Query: 370 ALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYV 419
AL+ + + +D+LSF+ G+ +++ E + WC+G+LQ R G++PA +V
Sbjct: 645 ALHSFTAETSDDLSFKRGDR-IQILERLDSDWCRGRLQD-REGIFPAVFV 692
Score = 37.7 bits (86), Expect = 0.020
Identities = 16/52 (30%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 371 LYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
L+D+ ++ D+L+ +GE ++ + E+ + W +G ++ +IG++PANYV+ +
Sbjct: 480 LHDFPAEQVDDLNLTSGE-IVYLLEKIDTDWYRGNCRN-QIGIFPANYVKVI 529
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 51.6 bits (122), Expect = 1e-06
Identities = 22/56 (39%), Positives = 38/56 (67%), Gaps = 2/56 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
G + +ALYD+ G+ DELSF+AG+ + ++ D+ W G+L G+ G++P NY++
Sbjct: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQ 785
Score = 46.2 bits (108), Expect = 6e-05
Identities = 23/58 (39%), Positives = 38/58 (65%), Gaps = 2/58 (3%)
Query: 365 GVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
G R A ++Y G++ DELSF G E++ + E + W +G+++ GR G++P N+VE V
Sbjct: 573 GSRCVARFEYIGEQKDELSFSEG-EIIILKEYVNEEWARGEVR-GRTGIFPLNFVEPV 628
Score = 39.7 bits (91), Expect = 0.005
Identities = 18/50 (36%), Positives = 34/50 (68%), Gaps = 2/50 (4%)
Query: 370 ALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYV 419
AL+ + + +D+LSF+ G+ +++ E + WC+G+LQ R G++PA +V
Sbjct: 668 ALHSFTAETSDDLSFKRGDR-IQILERLDSDWCRGRLQD-REGIFPAVFV 715
Score = 37.7 bits (86), Expect = 0.020
Identities = 16/52 (30%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 371 LYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECV 422
L+D+ ++ D+L+ +GE ++ + E+ + W +G ++ +IG++PANYV+ +
Sbjct: 503 LHDFPAEQVDDLNLTSGE-IVYLLEKIDTDWYRGNCRN-QIGIFPANYVKVI 552
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 51.2 bits (121), Expect = 2e-06
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 337 PPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEE 396
P + G+PG + A G+ ALYDY + DELS R G+ + +S++
Sbjct: 13 PVSSAGGAPGGSASSSSTSSGGSASAGAGLWA-ALYDYEARGEDELSLRRGQLVEVLSQD 71
Query: 397 ----DEQGWCQGQLQSGRIGLYPANYV 419
++GW GQ+Q R+G++PANYV
Sbjct: 72 AAVSGDEGWWAGQVQR-RLGIFPANYV 97
>gi|226371723 FCH domain only 2 isoform a [Homo sapiens]
Length = 810
Score = 50.8 bits (120), Expect = 2e-06
Identities = 55/261 (21%), Positives = 109/261 (41%), Gaps = 41/261 (15%)
Query: 15 SFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGP 72
+FW N V ++ G +L +ERA IE+AY++ + A+ +
Sbjct: 9 NFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAK----SASNYS 64
Query: 73 QYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAA 132
Q GT W F T+ E+L+ HL++ KLQ E ++ Q+ + + ++++
Sbjct: 65 QLGTFAPVWDVFKTSTEKLANCHLDLVRKLQ----ELIKEVQK--YGEEQVKSHKKTKEE 118
Query: 133 EDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRK---LQ 189
G +A + + ++ SK++Y+A V QE+L+K Q
Sbjct: 119 VAGTLEAVQTIQSITQALQKSKENYNA------------------KCVEQERLKKEGATQ 160
Query: 190 ERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTL 249
+E+ A +++K Y+ + + + + M + + Q E L+ K+++ +L
Sbjct: 161 REIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSL 220
Query: 250 HQHLDLSSSEKFHELHRDLHQ 270
S E+H + Q
Sbjct: 221 --------SNAIKEIHLQIGQ 233
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 50.4 bits (119), Expect = 3e-06
Identities = 28/77 (36%), Positives = 47/77 (61%), Gaps = 3/77 (3%)
Query: 344 SPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQ 403
SPGT + +S AA +V +YDY Q DEL+F G+ + +++ED W +
Sbjct: 1137 SPGTSKITPTEPPKSTALAAV-CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPD-WWK 1194
Query: 404 GQLQSGRIGLYPANYVE 420
G++ +G++GL+P+NYV+
Sbjct: 1195 GEV-NGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 1e-04
Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 60/286 (20%)
Query: 144 LKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTK 203
LKR E + + + + DE +TR + D + QL++L+E + ++ +K K
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKETRSKLQEID--IFNNQLKELREIHNK--QQLQKQK 623
Query: 204 AQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHE 263
+ + L + + R + ++E+ E Q ++R Q L+ E H+
Sbjct: 624 SMEAERLKQKEQ--ERKIIELEKQKEEAQRRAQERD----------KQWLEHVQQEDEHQ 671
Query: 264 LHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRK---EKGGRSP 320
R LH EE L + ++ +K EKG +
Sbjct: 672 RPRKLH------------------------------EEEKLKREESVKKKDGEEKGKQEA 701
Query: 321 DEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEAD 380
+ ++ P Q+P S S +E+ + V RALY + + D
Sbjct: 702 QDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKV----VYYRALYPFESRSHD 757
Query: 381 ELSFRAGE------ELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
E++ + G+ E + S+ E GW G+L+ G+ G +PANY E
Sbjct: 758 EITIQPGDIVMVKGEWVDESQTGEPGWLGGELK-GKTGWFPANYAE 802
Score = 33.9 bits (76), Expect = 0.29
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 27/140 (19%)
Query: 283 WWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSP 342
W ST+ NW + W+ T+ G+ T T G++P
Sbjct: 857 WPTSTNEKPETDNW---DAWAAQPSLTVP---SAGQLRQRSAFTPATAT--GSSP----- 903
Query: 343 GSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWC 402
SP GQ E+ G++ +ALY + ++ + L+F + + + ++D W
Sbjct: 904 -SPVLGQGEK----------VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM--WW 950
Query: 403 QGQLQSGRIGLYPANYVECV 422
G++Q G+ G +P +YV+ +
Sbjct: 951 FGEVQ-GQKGWFPKSYVKLI 969
Score = 32.7 bits (73), Expect = 0.64
Identities = 16/60 (26%), Positives = 32/60 (53%), Gaps = 3/60 (5%)
Query: 360 RKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYV 419
+ +G A+Y Y E +L+F+ G+ +L ++ + W G + + G++P+NYV
Sbjct: 999 KPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD--WWTGTV-GDKAGVFPSNYV 1055
Score = 31.6 bits (70), Expect = 1.4
Identities = 16/56 (28%), Positives = 33/56 (58%), Gaps = 5/56 (8%)
Query: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSG----RIGLYPANYVE 420
+ + Y ++L+ G+ L+ + +++ GW +G+LQ+ +IG +PANYV+
Sbjct: 1080 QVIASYTATGPEQLTLAPGQ-LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 50.4 bits (119), Expect = 3e-06
Identities = 28/77 (36%), Positives = 47/77 (61%), Gaps = 3/77 (3%)
Query: 344 SPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQ 403
SPGT + +S AA +V +YDY Q DEL+F G+ + +++ED W +
Sbjct: 1137 SPGTSKITPTEPPKSTALAAV-CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPD-WWK 1194
Query: 404 GQLQSGRIGLYPANYVE 420
G++ +G++GL+P+NYV+
Sbjct: 1195 GEV-NGQVGLFPSNYVK 1210
Score = 45.4 bits (106), Expect = 1e-04
Identities = 63/286 (22%), Positives = 113/286 (39%), Gaps = 60/286 (20%)
Query: 144 LKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTK 203
LKR E + + + + DE +TR + D + QL++L+E + ++ +K K
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKETRSKLQEID--IFNNQLKELREIHNK--QQLQKQK 623
Query: 204 AQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHE 263
+ + L + + R + ++E+ E Q ++R Q L+ E H+
Sbjct: 624 SMEAERLKQKEQ--ERKIIELEKQKEEAQRRAQERD----------KQWLEHVQQEDEHQ 671
Query: 264 LHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRK---EKGGRSP 320
R LH EE L + ++ +K EKG +
Sbjct: 672 RPRKLH------------------------------EEEKLKREESVKKKDGEEKGKQEA 701
Query: 321 DEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEAD 380
+ ++ P Q+P S S +E+ + V RALY + + D
Sbjct: 702 QDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKV----VYYRALYPFESRSHD 757
Query: 381 ELSFRAGE------ELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
E++ + G+ E + S+ E GW G+L+ G+ G +PANY E
Sbjct: 758 EITIQPGDIVMVKGEWVDESQTGEPGWLGGELK-GKTGWFPANYAE 802
Score = 33.9 bits (76), Expect = 0.29
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 27/140 (19%)
Query: 283 WWRSTHGPGMAMNWPQFEEWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSP 342
W ST+ NW + W+ T+ G+ T T G++P
Sbjct: 857 WPTSTNEKPETDNW---DAWAAQPSLTVP---SAGQLRQRSAFTPATAT--GSSP----- 903
Query: 343 GSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWC 402
SP GQ E+ G++ +ALY + ++ + L+F + + + ++D W
Sbjct: 904 -SPVLGQGEK----------VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM--WW 950
Query: 403 QGQLQSGRIGLYPANYVECV 422
G++Q G+ G +P +YV+ +
Sbjct: 951 FGEVQ-GQKGWFPKSYVKLI 969
Score = 32.7 bits (73), Expect = 0.64
Identities = 16/60 (26%), Positives = 32/60 (53%), Gaps = 3/60 (5%)
Query: 360 RKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYV 419
+ +G A+Y Y E +L+F+ G+ +L ++ + W G + + G++P+NYV
Sbjct: 999 KPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD--WWTGTV-GDKAGVFPSNYV 1055
Score = 31.6 bits (70), Expect = 1.4
Identities = 16/56 (28%), Positives = 33/56 (58%), Gaps = 5/56 (8%)
Query: 369 RALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSG----RIGLYPANYVE 420
+ + Y ++L+ G+ L+ + +++ GW +G+LQ+ +IG +PANYV+
Sbjct: 1080 QVIASYTATGPEQLTLAPGQ-LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,017,508
Number of Sequences: 37866
Number of extensions: 874284
Number of successful extensions: 5874
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 422
Number of HSP's that attempted gapping in prelim test: 4661
Number of HSP's gapped (non-prelim): 1414
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.