Search of human proteins with 190886437

Search of human proteins with 190886437

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190886437 RALBP1 associated Eps domain containing 1 isoform
b [Homo sapiens]
         (769 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190886437 RALBP1 associated Eps domain containing 1 isoform b...  1545   0.0  
gi|190886435 RALBP1 associated Eps domain containing 1 isoform a...  1524   0.0  
gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2...   367   e-101
gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1...   363   e-100
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                77   5e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                77   5e-14
gi|10864047 epidermal growth factor receptor pathway substrate 1...    73   9e-13
gi|7657056 EH-domain containing 3 [Homo sapiens]                       71   3e-12
gi|30240932 EH-domain containing 1 [Homo sapiens]                      71   3e-12
gi|4503593 epidermal growth factor receptor pathway substrate 15...    71   4e-12
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    69   2e-11
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    69   2e-11
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    69   2e-11
gi|21361462 EH-domain containing 2 [Homo sapiens]                      69   2e-11
gi|21264315 EH-domain containing 4 [Homo sapiens]                      67   6e-11
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s...    61   4e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    54   7e-07
gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap...    51   5e-06
gi|33946282 hypothetical protein LOC25962 isoform 1 [Homo sapiens]     50   6e-06
gi|33946280 hypothetical protein LOC25962 isoform 2 [Homo sapiens]     50   6e-06
gi|110349719 titin isoform N2-A [Homo sapiens]                         48   3e-05
gi|148806884 AKT1 substrate 1 (proline-rich) [Homo sapiens]            48   3e-05
gi|148806906 AKT1 substrate 1 (proline-rich) [Homo sapiens]            48   3e-05
gi|148806896 AKT1 substrate 1 (proline-rich) [Homo sapiens]            48   3e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        48   3e-05
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                    48   4e-05
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                  46   1e-04
gi|112382214 SEC24 (S. cerevisiae) homolog B isoform b [Homo sap...    45   3e-04
gi|223972704 hypothetical protein LOC284418 [Homo sapiens]             45   3e-04
gi|41281612 zinc finger protein 828 [Homo sapiens]                     45   3e-04

>gi|190886437 RALBP1 associated Eps domain containing 1 isoform b
           [Homo sapiens]
          Length = 769

 Score = 1545 bits (3999), Expect = 0.0
 Identities = 769/769 (100%), Positives = 769/769 (100%)

Query: 1   MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR 60
           MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR
Sbjct: 1   MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR 60

Query: 61  LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS 120
           LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS
Sbjct: 61  LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS 120

Query: 121 ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK 180
           ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK
Sbjct: 121 ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK 180

Query: 181 HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS 240
           HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS
Sbjct: 181 HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS 240

Query: 241 TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL 300
           TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL
Sbjct: 241 TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL 300

Query: 301 NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP 360
           NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP
Sbjct: 301 NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP 360

Query: 361 EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSED 420
           EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSED
Sbjct: 361 EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSED 420

Query: 421 TAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGN 480
           TAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGN
Sbjct: 421 TAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGN 480

Query: 481 TVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNR 540
           TVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNR
Sbjct: 481 TVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNR 540

Query: 541 TFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNF 600
           TFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNF
Sbjct: 541 TFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNF 600

Query: 601 ADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPA 660
           ADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPA
Sbjct: 601 ADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPA 660

Query: 661 NVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKA 720
           NVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKA
Sbjct: 661 NVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKA 720

Query: 721 IQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL 769
           IQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL
Sbjct: 721 IQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL 769


>gi|190886435 RALBP1 associated Eps domain containing 1 isoform a
           [Homo sapiens]
          Length = 795

 Score = 1524 bits (3945), Expect = 0.0
 Identities = 768/796 (96%), Positives = 768/796 (96%), Gaps = 28/796 (3%)

Query: 1   MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR 60
           MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR
Sbjct: 1   MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATR 60

Query: 61  LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS 120
           LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS
Sbjct: 61  LGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDS 120

Query: 121 ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK 180
           ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK
Sbjct: 121 ENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRK 180

Query: 181 HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS 240
           HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS
Sbjct: 181 HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTS 240

Query: 241 TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL 300
           TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL
Sbjct: 241 TLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDL 300

Query: 301 NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP 360
           NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP
Sbjct: 301 NGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLP 360

Query: 361 EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSE- 419
           EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSE 
Sbjct: 361 EKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQ 420

Query: 420 --------------------------DTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNP 453
                                     DTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNP
Sbjct: 421 WETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNP 480

Query: 454 TSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTS 513
           TSPLLVKPSDLLEENKINSSVKFASGNTV DGYSSSDSFTSDPEQIGSNVTRQRSHSGTS
Sbjct: 481 TSPLLVKPSDLLEENKINSSVKFASGNTV-DGYSSSDSFTSDPEQIGSNVTRQRSHSGTS 539

Query: 514 PDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPA 573
           PDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPA
Sbjct: 540 PDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPA 599

Query: 574 VHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEK 633
           VHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEK
Sbjct: 600 VHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEK 659

Query: 634 ASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEH 693
           ASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEH
Sbjct: 660 ASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEH 719

Query: 694 TQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEER 753
           TQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEER
Sbjct: 720 TQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEER 779

Query: 754 ISLEVQLEQLRPFSHL 769
           ISLEVQLEQLRPFSHL
Sbjct: 780 ISLEVQLEQLRPFSHL 795


>gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2
           [Homo sapiens]
          Length = 659

 Score =  367 bits (943), Expect = e-101
 Identities = 270/791 (34%), Positives = 372/791 (47%), Gaps = 184/791 (23%)

Query: 4   LTLSDAEQKYYSDLFSYCD----------------IESTKKVVVNGRVLELFRAAQLPND 47
           L LS+ EQ+ YS+LF+ C                 +         G V +LFRA+QLP +
Sbjct: 28  LLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAE 87

Query: 48  VVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNE 107
            + QI ELCGA R+GYFG +QFYIALKL+A AQSG P+R+ESI    +LPLPRF+ SKN+
Sbjct: 88  TLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKC--ELPLPRFMMSKND 145

Query: 108 QESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSP 167
            E R    + + +E  G+          + Q+   +   ++ +     D QE  SP +SP
Sbjct: 146 GEIR----FGNPAELHGT----------KVQIPYLTTEKNSFKRMDDEDKQETQSPTMSP 191

Query: 168 QQSPPTSPHTWRK----HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSP 223
             SPP+SP  +++    H       ++E+    P     P  + +  SS G         
Sbjct: 192 LASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGG--------- 242

Query: 224 PPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITD 283
                        P T  L   H AS+        + S +   E++  SS  D+PW+IT+
Sbjct: 243 -------------PGTKPL--RHQASL--------IRSFSVERELQDNSSYPDEPWRITE 279

Query: 284 EQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEF 343
           EQR+YYVNQF+++QPD + FI GS AK FFTKSKL I ELS+IWELSD D DGALTL EF
Sbjct: 280 EQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEF 339

Query: 344 CAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPS 403
           CAAFHL+VARKNGY LPE LP +L P+ +         D            +   S S S
Sbjct: 340 CAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWD-----------CQLFDSYSES 388

Query: 404 MPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSD 463
           +P+                              + Q  +L R         + L V   D
Sbjct: 389 LPA------------------------------NQQPRDLNRMEKTSVKDMADLPVPNQD 418

Query: 464 LLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTA----- 518
           +  ++K   ++K      +    S   +   D   + +   R RS+S TS +        
Sbjct: 419 VTSDDK--QALKSTINEALPKDVSEDPATPKDSNSLKAR-PRSRSYSSTSIEEAMKRGED 475

Query: 519 PPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPV 578
           PP PPPRPQ +HSR+SSLD+N+ F  +    ++G++  PPA+PPRP PSQ+        V
Sbjct: 476 PPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQS------EQV 529

Query: 579 DADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPA 638
               L+   S +P Q                 A+  +  + D     P   P  +   P 
Sbjct: 530 SEAELLPQLSRAPSQ-----------------AAESSPAKKDVLYSQPPSKPIRRKFRPE 572

Query: 639 SSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTG 698
           +     +     E  TAAS PA+                                     
Sbjct: 573 N-----QATENQEPSTAASGPAS------------------------------------- 590

Query: 699 VLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEV 758
             AA +   P++ +   K KKAIQ +IR+NKE N VLARLNSELQQQLK+V +ERI+LE 
Sbjct: 591 --AATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALEN 648

Query: 759 QLEQLRPFSHL 769
           QLEQLRP + L
Sbjct: 649 QLEQLRPVTVL 659


>gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1
           [Homo sapiens]
          Length = 660

 Score =  363 bits (931), Expect = e-100
 Identities = 270/792 (34%), Positives = 372/792 (46%), Gaps = 185/792 (23%)

Query: 4   LTLSDAEQKYYSDLFSYCD----------------IESTKKVVVNGRVLELFRAAQLPND 47
           L LS+ EQ+ YS+LF+ C                 +         G V +LFRA+QLP +
Sbjct: 28  LLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAE 87

Query: 48  VVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNE 107
            + QI ELCGA R+GYFG +QFYIALKL+A AQSG P+R+ESI    +LPLPRF+ SKN+
Sbjct: 88  TLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKC--ELPLPRFMMSKND 145

Query: 108 QESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQ-EPASPVVS 166
            E R    + + +E  G+          + Q+   +   ++ +     D Q E  SP +S
Sbjct: 146 GEIR----FGNPAELHGT----------KVQIPYLTTEKNSFKRMDDEDKQQETQSPTMS 191

Query: 167 PQQSPPTSPHTWRK----HSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHS 222
           P  SPP+SP  +++    H       ++E+    P     P  + +  SS G        
Sbjct: 192 PLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGG-------- 243

Query: 223 PPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKIT 282
                         P T  L   H AS+        + S +   E++  SS  D+PW+IT
Sbjct: 244 --------------PGTKPL--RHQASL--------IRSFSVERELQDNSSYPDEPWRIT 279

Query: 283 DEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDE 342
           +EQR+YYVNQF+++QPD + FI GS AK FFTKSKL I ELS+IWELSD D DGALTL E
Sbjct: 280 EEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPE 339

Query: 343 FCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSP 402
           FCAAFHL+VARKNGY LPE LP +L P+ +         D            +   S S 
Sbjct: 340 FCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWD-----------CQLFDSYSE 388

Query: 403 SMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPS 462
           S+P+                              + Q  +L R         + L V   
Sbjct: 389 SLPA------------------------------NQQPRDLNRMEKTSVKDMADLPVPNQ 418

Query: 463 DLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTA---- 518
           D+  ++K   ++K      +    S   +   D   + +   R RS+S TS +       
Sbjct: 419 DVTSDDK--QALKSTINEALPKDVSEDPATPKDSNSLKAR-PRSRSYSSTSIEEAMKRGE 475

Query: 519 -PPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRP 577
            PP PPPRPQ +HSR+SSLD+N+ F  +    ++G++  PPA+PPRP PSQ+        
Sbjct: 476 DPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQS------EQ 529

Query: 578 VDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDP 637
           V    L+   S +P Q                 A+  +  + D     P   P  +   P
Sbjct: 530 VSEAELLPQLSRAPSQ-----------------AAESSPAKKDVLYSQPPSKPIRRKFRP 572

Query: 638 ASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKT 697
            +     +     E  TAAS PA+                                    
Sbjct: 573 EN-----QATENQEPSTAASGPAS------------------------------------ 591

Query: 698 GVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLE 757
              AA +   P++ +   K KKAIQ +IR+NKE N VLARLNSELQQQLK+V +ERI+LE
Sbjct: 592 ---AATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALE 648

Query: 758 VQLEQLRPFSHL 769
            QLEQLRP + L
Sbjct: 649 NQLEQLRPVTVL 660


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 121/515 (23%), Positives = 199/515 (38%), Gaps = 54/515 (10%)

Query: 277 DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDG 336
           D W IT E+R  +  QF +++P ++GFI G  A+ FF +S LP   L+ IW L+D + DG
Sbjct: 13  DIWAITVEERAKHDQQFHSLKP-ISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDG 71

Query: 337 ALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEA 396
            +   EF  A  L+  +  GY LP  LP  +  + + +  +   G   G +         
Sbjct: 72  RMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFG--MGGIASMPPLTAV 129

Query: 397 PPSKSPSMPSLNQTWPELNQSSEDTAIVHPVP------IRMTPSKIHMQEMELKRTGSDH 450
            P    S+P +  + P L  SS  TA V P+       I+  P+  H      K +    
Sbjct: 130 APVPMGSIPVVGMS-PTL-VSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSR 187

Query: 451 TNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHS 510
           + P S L  K            S   AS   VA+ ++   S      Q+ ++  +  S  
Sbjct: 188 SGPGSQLNTKLQKA-------QSFDVASVPPVAE-WAVPQSSRLKYRQLFNSHDKTMSGH 239

Query: 511 GTSPDNTAPPPPPPRPQ---PSHSRSSSLDMNRTFTV---TTGQQQAGVVAHPPAVPPRP 564
            T P           PQ    S    S +D +   T            V      +PP  
Sbjct: 240 LTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVL 299

Query: 565 QPSQAPGPAVHRPVDADGLITHTSTS-PQQIPEQPNFADFSQ---------FEVFAASNV 614
            P   P P+  R     G+   +STS  Q++PE+P   D  Q         FE     N 
Sbjct: 300 PPEYIP-PSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENF 358

Query: 615 NDEQDDEAEKHPEVL--PAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPP 672
            +  + E EK  + L     K  +  + L  A+ + K  E+        +          
Sbjct: 359 -ERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLE--------- 408

Query: 673 PKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASI-RRNKET 731
              + ++L+ + EL  + +E  +K          +    R +  ++   Q  + +RNKE 
Sbjct: 409 ---LEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQ 465

Query: 732 N--TVLARLNSELQQQLKDVLEERISLEVQLEQLR 764
               VL      L+ +L+ + +++  LE +L+ +R
Sbjct: 466 EDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIR 500


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 121/515 (23%), Positives = 199/515 (38%), Gaps = 54/515 (10%)

Query: 277 DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDG 336
           D W IT E+R  +  QF +++P ++GFI G  A+ FF +S LP   L+ IW L+D + DG
Sbjct: 13  DIWAITVEERAKHDQQFHSLKP-ISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDG 71

Query: 337 ALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEA 396
            +   EF  A  L+  +  GY LP  LP  +  + + +  +   G   G +         
Sbjct: 72  RMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFG--MGGIASMPPLTAV 129

Query: 397 PPSKSPSMPSLNQTWPELNQSSEDTAIVHPVP------IRMTPSKIHMQEMELKRTGSDH 450
            P    S+P +  + P L  SS  TA V P+       I+  P+  H      K +    
Sbjct: 130 APVPMGSIPVVGMS-PTL-VSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSR 187

Query: 451 TNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHS 510
           + P S L  K            S   AS   VA+ ++   S      Q+ ++  +  S  
Sbjct: 188 SGPGSQLNTKLQKA-------QSFDVASVPPVAE-WAVPQSSRLKYRQLFNSHDKTMSGH 239

Query: 511 GTSPDNTAPPPPPPRPQ---PSHSRSSSLDMNRTFTV---TTGQQQAGVVAHPPAVPPRP 564
            T P           PQ    S    S +D +   T            V      +PP  
Sbjct: 240 LTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVL 299

Query: 565 QPSQAPGPAVHRPVDADGLITHTSTS-PQQIPEQPNFADFSQ---------FEVFAASNV 614
            P   P P+  R     G+   +STS  Q++PE+P   D  Q         FE     N 
Sbjct: 300 PPEYIP-PSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENF 358

Query: 615 NDEQDDEAEKHPEVL--PAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPP 672
            +  + E EK  + L     K  +  + L  A+ + K  E+        +          
Sbjct: 359 -ERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLE--------- 408

Query: 673 PKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASI-RRNKET 731
              + ++L+ + EL  + +E  +K          +    R +  ++   Q  + +RNKE 
Sbjct: 409 ---LEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQ 465

Query: 732 N--TVLARLNSELQQQLKDVLEERISLEVQLEQLR 764
               VL      L+ +L+ + +++  LE +L+ +R
Sbjct: 466 EDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIR 500


>gi|10864047 epidermal growth factor receptor pathway substrate
           15-like 1 [Homo sapiens]
          Length = 864

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 77/274 (28%), Positives = 109/274 (39%), Gaps = 35/274 (12%)

Query: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
           W +  E++  +   F+++ P +NG + G   K     SKLP+  L  +W+LSD DKDG L
Sbjct: 121 WAVRVEEKAKFDGIFESLLP-INGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHL 179

Query: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPP 398
             DEF  A HLV        +P  LP SL+P              PG V     PA  PP
Sbjct: 180 DRDEFAVAMHLVYRALEKEPVPSALPPSLIP-----PSKRKKTVFPGAVPV--LPASPPP 232

Query: 399 SKS-------PSMPSLNQTW---PELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGS 448
             S        S+ SLN T    P+ +       +   VP+     K+   E+ LK T  
Sbjct: 233 KDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPV---ADKMRFDEIFLK-TDL 288

Query: 449 DHTNPTSPLLVKPSDLLEENKINSSVK---FASGNTVADGYSSSDSFTSDPEQIGSNVTR 505
           D     S   VK  ++   + +  ++    +A  +T   G  S D F      +     +
Sbjct: 289 DLDGYVSGQEVK--EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFA-----LAMYFIQ 341

Query: 506 QRSHSGTSPDNTAPP---PPPPRPQPSHSRSSSL 536
           Q+   G  P     P   PP  R  P    S SL
Sbjct: 342 QKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSL 375



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 79/373 (21%), Positives = 146/373 (39%), Gaps = 48/373 (12%)

Query: 14  YSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVL-QIMELCGATRLGYFGRSQFYIA 72
           Y   +   D   T +V  +   L L ++    +D++L +I +L      G+  +  FY+A
Sbjct: 19  YESYYKQVDPAYTGRVGASEAALFLKKSGL--SDIILGKIWDLADPEGKGFLDKQGFYVA 76

Query: 73  LKLVAVAQSGFPLRVESINTVKDLPLPRF-------VASKNEQESRHAASYSSDSENQGS 125
           L+LVA AQSG  + + ++N    +P P+F       + +    E+  A      ++  G 
Sbjct: 77  LRLVACAQSGHEVTLSNLNL--SMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGI 134

Query: 126 YSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPV--------VSPQQSPPTSPHT 177
           +  ++P          G +S D V+P    +++ P   +        +            
Sbjct: 135 FESLLP--------INGLLSGDKVKP-VLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFA 185

Query: 178 WRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTP 237
              H  + +      P A P     P       S     V+ G  P  P       A  P
Sbjct: 186 VAMHLVYRALEKEPVPSALPPSLIPP-------SKRKKTVFPGAVPVLP-------ASPP 231

Query: 238 PTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQ 297
           P  +L +    S    +++ +  S +    +++   + +  W +    +  +   F    
Sbjct: 232 PKDSLRS--TPSHGSVSSLNSTGSLSPKHSLKQTQPTVN--WVVPVADKMRFDEIFLKTD 287

Query: 298 PDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVAR-KNG 356
            DL+G++ G   KE F  S L    L+HIW L+D  + G L+ D+F  A + +  +   G
Sbjct: 288 LDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKG 347

Query: 357 YDLPEKLPESLMP 369
            D P+ L   ++P
Sbjct: 348 IDPPQVLSPDMVP 360


>gi|7657056 EH-domain containing 3 [Homo sapiens]
          Length = 535

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 38/94 (40%), Positives = 54/94 (57%), Gaps = 1/94 (1%)

Query: 276 DDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKD 335
           DD   +    +  Y   F T+ P ++G I G+ AK+   +SKLP   L  IW+L+D DKD
Sbjct: 435 DDAEWVVARDKPMYDEIFYTLSP-VDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKD 493

Query: 336 GALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
           G L  DEF  A HL+  +  G++LP +LP  L+P
Sbjct: 494 GMLDDDEFALANHLIKVKLEGHELPNELPAHLLP 527


>gi|30240932 EH-domain containing 1 [Homo sapiens]
          Length = 534

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 39/94 (41%), Positives = 54/94 (57%), Gaps = 1/94 (1%)

Query: 276 DDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKD 335
           DD   +  + +  Y   F T+ P +NG I G+ AK+   KSKLP   L  IW+L+D DKD
Sbjct: 435 DDVEWVVGKDKPTYDEIFYTLSP-VNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKD 493

Query: 336 GALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
           G L  +EF  A HL+  +  G++LP  LP  L+P
Sbjct: 494 GLLDDEEFALANHLIKVKLEGHELPADLPPHLVP 527


>gi|4503593 epidermal growth factor receptor pathway substrate 15
           isoform A [Homo sapiens]
          Length = 896

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 11/131 (8%)

Query: 239 TSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQP 298
           +S  L + P    D T+   + S T+A E+         PW +  E +  Y   F ++ P
Sbjct: 92  SSLNLAVPPPRFHD-TSSPLLISGTSAAEL---------PWAVKPEDKAKYDAIFDSLSP 141

Query: 299 DLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYD 358
            +NGF+ G   K     SKLP+  L  +WELSD D DG L  DEF  A  LV        
Sbjct: 142 -VNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP 200

Query: 359 LPEKLPESLMP 369
           +P  LP +L+P
Sbjct: 201 VPMSLPPALVP 211



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 1/92 (1%)

Query: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
           W ++  ++  Y   F     D++GF+ G   +E F K+ LP   L+HIW L D    G L
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277

Query: 339 TLDEFCAAFHLVVARK-NGYDLPEKLPESLMP 369
           + D+F  AFHL+  +   G D P  L   ++P
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIP 309



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 10/102 (9%)

Query: 289 YVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFH 348
           Y   ++ +     G +  S A  F  KS LP L L  IW+L+D D  G L   EF  A  
Sbjct: 19  YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78

Query: 349 LVVARKNGYDL----------PEKLPESLMPKLIDLEDSADV 380
           LV   +NG ++          P +  ++  P LI    +A++
Sbjct: 79  LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL 120



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 41/213 (19%)

Query: 4   LTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGY 63
           LT   +    Y   +   D  +T +V+ +     L ++  LP+ ++ +I +L      G 
Sbjct: 9   LTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSG-LPDLILGKIWDLADTDGKGI 67

Query: 64  FGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRF------------------VASK 105
             + +F++AL+LVA AQ+G  + + S+N    +P PRF                   A K
Sbjct: 68  LNKQEFFVALRLVACAQNGLEVSLSSLNLA--VPPPRFHDTSSPLLISGTSAAELPWAVK 125

Query: 106 NEQESRHAASYSSDSENQGSYSG--VIP-------PPPGRGQV-KKGSVSHDTVQPRTS- 154
            E ++++ A + S S   G  SG  V P       P    G+V +   + HD +  R   
Sbjct: 126 PEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEF 185

Query: 155 ---------ADAQEPASPVVSPQQSPPTSPHTW 178
                    A  +EP    + P   PP+   TW
Sbjct: 186 AVAMFLVYCALEKEPVPMSLPPALVPPSKRKTW 218



 Score = 33.1 bits (74), Expect = 1.00
 Identities = 36/152 (23%), Positives = 63/152 (41%), Gaps = 6/152 (3%)

Query: 6   LSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFG 65
           +S AE+  Y ++F   D +     V    V E+F    LP+ ++  I  LC     G   
Sbjct: 220 VSPAEKAKYDEIFLKTD-KDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLS 278

Query: 66  RSQFYIALKLVA--VAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQ 123
           + QF +A  L++  + +   P  V +   +   P  R    KN   S   A +S+  E  
Sbjct: 279 KDQFALAFHLISQKLIKGIDPPHVLTPEMIP--PSDRASLQKNIIGSSPVADFSAIKELD 336

Query: 124 GSYSGVIPPPPGRGQVKKG-SVSHDTVQPRTS 154
              + ++     +  V++      DT++ RTS
Sbjct: 337 TLNNEIVDLQREKNNVEQDLKEKEDTIKQRTS 368


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 28/229 (12%)

Query: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
           W IT E+R  +  QF  ++P   G+I G  A+ FF +S LP   L+ IW LSD +KDG +
Sbjct: 16  WAITSEERTKHDRQFDNLKPS-GGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74

Query: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESL-MPKLIDLEDSADVGDQPGEVGYSGSPAEAP 397
              EF  A  L+  +  G  LP  LP  +  P +     SA  G   G +     P   P
Sbjct: 75  DQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFG--MGSMPNLSIPQPLP 132

Query: 398 P----------SKSPSMPSLNQTWPELNQSSEDT------AIVHPVPIRMTPSKI-HMQE 440
           P          +   ++P L    P +   S  +      +++ P+PI  + S + H   
Sbjct: 133 PAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSS 192

Query: 441 MELKRTGSDHTNPTSPLLVKPSDLLE--ENKINSSVKFASGNTVADGYS 487
             L   G    +     + K   L++   +   SS    SGN+   G S
Sbjct: 193 YSLMMGGFGGAS-----IQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 127/345 (36%), Gaps = 61/345 (17%)

Query: 30  VVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVES 89
           +   +    F  + LP  V+ +I  L    + G   + +F IA+KL+ +   G  L V  
Sbjct: 40  ITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL 99

Query: 90  INTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTV 149
              +K  P+                           +S +I    G G +   S+     
Sbjct: 100 PPIMKQPPM---------------------------FSPLISARFGMGSMPNLSI----- 127

Query: 150 QPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQS 209
                            PQ  PP +P T    +   + G +  PL  P    +P   + S
Sbjct: 128 -----------------PQPLPPAAPITSLSSA---TSGTNLPPLMMP----TPLVPSVS 163

Query: 210 GSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLT-MHPASVQDQTTVRTVASATTAIEI 268
            SS  +   S   P P   +  +       S ++     AS+Q   ++  + S+++    
Sbjct: 164 TSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSST 223

Query: 269 RRQSSSYD----DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELS 324
              S +        W +    R  Y  +F T+   ++G++ G  A+    +S L   +L+
Sbjct: 224 ASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLA 283

Query: 325 HIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
            IW L+D D DG L  +EF  A HL    K G  LP  LP  L+P
Sbjct: 284 TIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVP 328


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 28/229 (12%)

Query: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
           W IT E+R  +  QF  ++P   G+I G  A+ FF +S LP   L+ IW LSD +KDG +
Sbjct: 16  WAITSEERTKHDRQFDNLKPS-GGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74

Query: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESL-MPKLIDLEDSADVGDQPGEVGYSGSPAEAP 397
              EF  A  L+  +  G  LP  LP  +  P +     SA  G   G +     P   P
Sbjct: 75  DQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFG--MGSMPNLSIPQPLP 132

Query: 398 P----------SKSPSMPSLNQTWPELNQSSEDT------AIVHPVPIRMTPSKI-HMQE 440
           P          +   ++P L    P +   S  +      +++ P+PI  + S + H   
Sbjct: 133 PAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSS 192

Query: 441 MELKRTGSDHTNPTSPLLVKPSDLLE--ENKINSSVKFASGNTVADGYS 487
             L   G    +     + K   L++   +   SS    SGN+   G S
Sbjct: 193 YSLMMGGFGGAS-----IQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 127/345 (36%), Gaps = 61/345 (17%)

Query: 30  VVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVES 89
           +   +    F  + LP  V+ +I  L    + G   + +F IA+KL+ +   G  L V  
Sbjct: 40  ITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL 99

Query: 90  INTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTV 149
              +K  P+                           +S +I    G G +   S+     
Sbjct: 100 PPIMKQPPM---------------------------FSPLISARFGMGSMPNLSI----- 127

Query: 150 QPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQS 209
                            PQ  PP +P T    +   + G +  PL  P    +P   + S
Sbjct: 128 -----------------PQPLPPAAPITSLSSA---TSGTNLPPLMMP----TPLVPSVS 163

Query: 210 GSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLT-MHPASVQDQTTVRTVASATTAIEI 268
            SS  +   S   P P   +  +       S ++     AS+Q   ++  + S+++    
Sbjct: 164 TSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSST 223

Query: 269 RRQSSSYD----DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELS 324
              S +        W +    R  Y  +F T+   ++G++ G  A+    +S L   +L+
Sbjct: 224 ASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLA 283

Query: 325 HIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
            IW L+D D DG L  +EF  A HL    K G  LP  LP  L+P
Sbjct: 284 TIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVP 328


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 28/229 (12%)

Query: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
           W IT E+R  +  QF  ++P   G+I G  A+ FF +S LP   L+ IW LSD +KDG +
Sbjct: 16  WAITSEERTKHDRQFDNLKPS-GGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74

Query: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESL-MPKLIDLEDSADVGDQPGEVGYSGSPAEAP 397
              EF  A  L+  +  G  LP  LP  +  P +     SA  G   G +     P   P
Sbjct: 75  DQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFG--MGSMPNLSIPQPLP 132

Query: 398 P----------SKSPSMPSLNQTWPELNQSSEDT------AIVHPVPIRMTPSKI-HMQE 440
           P          +   ++P L    P +   S  +      +++ P+PI  + S + H   
Sbjct: 133 PAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSS 192

Query: 441 MELKRTGSDHTNPTSPLLVKPSDLLE--ENKINSSVKFASGNTVADGYS 487
             L   G    +     + K   L++   +   SS    SGN+   G S
Sbjct: 193 YSLMMGGFGGAS-----IQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 127/345 (36%), Gaps = 61/345 (17%)

Query: 30  VVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVES 89
           +   +    F  + LP  V+ +I  L    + G   + +F IA+KL+ +   G  L V  
Sbjct: 40  ITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVL 99

Query: 90  INTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTV 149
              +K  P+                           +S +I    G G +   S+     
Sbjct: 100 PPIMKQPPM---------------------------FSPLISARFGMGSMPNLSI----- 127

Query: 150 QPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQS 209
                            PQ  PP +P T    +   + G +  PL  P    +P   + S
Sbjct: 128 -----------------PQPLPPAAPITSLSSA---TSGTNLPPLMMP----TPLVPSVS 163

Query: 210 GSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLT-MHPASVQDQTTVRTVASATTAIEI 268
            SS  +   S   P P   +  +       S ++     AS+Q   ++  + S+++    
Sbjct: 164 TSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSST 223

Query: 269 RRQSSSYD----DPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELS 324
              S +        W +    R  Y  +F T+   ++G++ G  A+    +S L   +L+
Sbjct: 224 ASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLA 283

Query: 325 HIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
            IW L+D D DG L  +EF  A HL    K G  LP  LP  L+P
Sbjct: 284 TIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVP 328


>gi|21361462 EH-domain containing 2 [Homo sapiens]
          Length = 543

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 2/105 (1%)

Query: 265 AIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELS 324
           A+E   + S  +  W +T ++ +Y    F  + P  +G + GS AK +   +KLP   L 
Sbjct: 430 AMEDGEEGSDDEAEWVVTKDKSKYD-EIFYNLAP-ADGKLSGSKAKTWMVGTKLPNSVLG 487

Query: 325 HIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
            IW+LSD D+DG L  +EF  A HL+ A+  G+ LP  LP  L+P
Sbjct: 488 RIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPANLPRRLVP 532


>gi|21264315 EH-domain containing 4 [Homo sapiens]
          Length = 541

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 2/94 (2%)

Query: 276 DDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKD 335
           ++ W +  + +  Y   F T+ P +NG I G  AK+    SKLP   L  IW+L+D D D
Sbjct: 439 EEEWVVAKD-KPVYDELFYTLSP-INGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCD 496

Query: 336 GALTLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
           G L  +EF  A HL+  + +GY+LP  LP  L+P
Sbjct: 497 GMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVP 530


>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
            sapiens]
          Length = 4911

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 117/545 (21%), Positives = 179/545 (32%), Gaps = 110/545 (20%)

Query: 105  KNEQESRHAASYSSD-----SENQGSYSGV---IPPPPGRGQVKKGSVSHD---TVQPRT 153
            KNEQ+ +    + S      S +    SG+   + P PG G +      H    T QP +
Sbjct: 1777 KNEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPS 1836

Query: 154  SADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSA 213
            +  +       V PQ  PP                    P     P      +AQ+    
Sbjct: 1837 TPTSTSSDDVFVKPQAPPPP-------------------PAPSRIPIQDSLSQAQTSQPP 1877

Query: 214  GDAVWSGHS----PPPPQENWVSFADTP----------------PTSTLLTMHPASVQDQ 253
               V+S  S    PP P + +     TP                P      +   S   Q
Sbjct: 1878 SPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQ 1937

Query: 254  TTVRTVASATTAIEIRRQSSSYDDPW-KITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEF 312
                T    +   ++   S++ +DP+ K  D  R    +QF    P   G        E 
Sbjct: 1938 MNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQF----PKSLGLSRSPVVSEQ 1993

Query: 313  FTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLI 372
              K  +      H  + S          D F                 +++P+S    L+
Sbjct: 1994 TAKGPIAAGTSDHFTKPSP-------RADVFQR---------------QRIPDSYARPLL 2031

Query: 373  DLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMT 432
                 A +   PG      +P + PPS      S++Q    L+    +   + P PI   
Sbjct: 2032 T---PAPLDSGPGPFK---TPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPI--- 2082

Query: 433  PSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSF 492
             +  H Q            +P S   + P   + E+  + S  F+   T++   +S D +
Sbjct: 2083 DNFSHNQS----------NDPYSQPPLTPHPAVNESFAHPSRAFSQPGTISRP-TSQDPY 2131

Query: 493  TSDPEQIGSNVTRQRSHSGTSPDNTAP---PPPPPRP--------QPSHSRSSSLDMNRT 541
            +  P      V      SGT+  NT P   PP  PRP        QP   R S+   +  
Sbjct: 2132 SQPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQTPRPST-QTDLF 2190

Query: 542  FTVTTGQQQAGVVAHPPAVP-PRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNF 600
             T  T Q+ +   AHPP  P P      +  PA  RP  ++G    + T P  +P Q  F
Sbjct: 2191 VTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQDPF 2250

Query: 601  ADFSQ 605
               +Q
Sbjct: 2251 LQAAQ 2255



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 56/242 (23%), Positives = 85/242 (35%), Gaps = 35/242 (14%)

Query: 508  SHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVT----TGQQQAGVVAHPPAVPPR 563
            S S T+ D  A PP  PRP  +     SL ++R+  V+     G   AG   H     PR
Sbjct: 1954 SSSTTNNDPYAKPPDTPRPVMTDQFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPR 2013

Query: 564  PQ--PSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDE 621
                  Q    +  RP+     +  +   P + P QP     SQ    + S  +     +
Sbjct: 2014 ADVFQRQRIPDSYARPLLTPAPL-DSGPGPFKTPMQP--PPSSQDPYGSVSQASRRLSVD 2070

Query: 622  AEKHPEVLPA-----------EKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTT--P 668
              + P + P            +  S P  +   A  +S      A S P  +S+ T+  P
Sbjct: 2071 PYERPALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQPGTISRPTSQDP 2130

Query: 669  LAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAA---VLASQPSIPRSVGKDKKAIQASI 725
             + PP             RP VD ++Q +G   +     +  P  PR    D  + Q   
Sbjct: 2131 YSQPP----------GTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQT 2180

Query: 726  RR 727
             R
Sbjct: 2181 PR 2182



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 8/84 (9%)

Query: 684  DELRPEVDEHTQKTGVLAAVLASQPSIPRSVG---KDKKAIQASIRRNKETNTVLARLNS 740
            D  R + +E  Q+T  L  +   Q  +   +G   K KKA+ A  R  K+        ++
Sbjct: 3174 DSQRKQYEEWLQETQQLLQM--QQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDA 3231

Query: 741  ELQQQLKDVLEERISLEVQLEQLR 764
            E   QLK V E++  ++ QLEQ+R
Sbjct: 3232 E---QLKHVTEQQSMVQKQLEQIR 3252


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 99/485 (20%), Positives = 171/485 (35%), Gaps = 44/485 (9%)

Query: 290 VNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHL 349
           VN  K +   +N  +  S+A  + + S+   L+LS  WE S  D+    TL     +   
Sbjct: 256 VNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLS-AWESSIVDRLMTPTLSFLARSRSA 314

Query: 350 VVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAP--PSKSPSMP-- 405
           V   +NG D          P       S   G QP     S +    P   S SP  P  
Sbjct: 315 VTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCS 374

Query: 406 ---SLNQTWP--ELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVK 460
              S+++  P  E  +  +  A   P P+R  P    +Q+ E K    ++    S L  +
Sbjct: 375 VTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARE 434

Query: 461 PSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPP 520
            S    ++   S     S +T ++    S +  S P              G  P +T PP
Sbjct: 435 RSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPG--PGHTLPP 492

Query: 521 PPP-PR---------------PQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHP---PAVP 561
            PP PR                + S S +   D +++    + ++++   A P   PA  
Sbjct: 493 KPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPS 552

Query: 562 PRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDE 621
           P P P Q   P    P DA  L +  + +P   P +P            A   + E+   
Sbjct: 553 PTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKP-----------MAGTTDREEATR 601

Query: 622 --AEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRR 679
             AEK  +     +  +    L+  +     EE+ A  A A   +         +  R +
Sbjct: 602 LLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREK 661

Query: 680 LKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLN 739
            ++E E +  + +  ++    +   A +  + R     ++  +   RR +    +     
Sbjct: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721

Query: 740 SELQQ 744
           SE+ +
Sbjct: 722 SEVSE 726



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 47/222 (21%), Positives = 73/222 (32%), Gaps = 17/222 (7%)

Query: 510 SGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQA 569
           +G  P   A  PP PRP P    S                 A V   PP  PP  + + +
Sbjct: 11  AGAPPAVVARTPPEPRPSPEGDPSP----------PPPPMSALVPDTPPDTPPAMKNATS 60

Query: 570 PGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVL 629
                  P    G +      PQ+  E P+    S+     A    D +       P   
Sbjct: 61  SKQLPLEPESPSGQVGPRPAPPQE--ESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPT 118

Query: 630 PAEKASDPASSLRVAKTDSK---TEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDEL 686
               +  P +   V K   +    +E+    A    +K    L    K    R K   E 
Sbjct: 119 AVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQER 178

Query: 687 RPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRN 728
           R  ++E   K     A L  +    + + K+K+  +A+I+R+
Sbjct: 179 RRRLEEQRLKAEQRRAALEERQR--QKLEKNKERYEAAIQRS 218


>gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo
           sapiens]
          Length = 1268

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 82/350 (23%), Positives = 125/350 (35%), Gaps = 36/350 (10%)

Query: 377 SADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKI 436
           S   GD  G++  S +     P K  S             S ++TAI HP P+   PS+ 
Sbjct: 200 SLPAGDTYGQMFTSQNAPTVRPVKDNSF------------SGQNTAISHPSPLPPLPSQQ 247

Query: 437 HMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGN---TVADGYSSSDSFT 493
           H Q+  L  +G      +SP L    D L  N    S+  A+ N   TVAD  S      
Sbjct: 248 HHQQQSL--SGYSTLTWSSPGLPSTQDNLIRNH-TGSLAVANNNPTITVADSLSCPVMQN 304

Query: 494 SDPEQIGSNVTRQRSHSGTSPDNTAPPPP--PPRPQPSHSRSSSLDMNRTFTVTTGQQQA 551
             P +    V+   S S  S     PP    P  P  S ++ S L   +      G Q  
Sbjct: 305 VQPPKSSPVVSTVLSGSSGSSSTRTPPTANHPVEPVTSVTQPSELLQQK------GVQYG 358

Query: 552 GVVAHPPAVPPRPQPSQAPGPAVHRPVDADGL-ITHTSTSPQQIPEQPNFADFSQFEVFA 610
             V +  +  P P  S +         +  G+  + T++S   +P   +  +   +    
Sbjct: 359 EYVNNQASSAPTPLSSTSDDEEEEEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDML 418

Query: 611 ASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPA---NVSKGTT 667
           +S+ +    D A   PE  PA   +  ++   V    SK  +      P         T 
Sbjct: 419 SSSASSPAPDPA---PEPDPASAPAPASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNATA 475

Query: 668 PL---APPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSV 714
           PL     P  PV    +   +  P V++ +   G L+   + QP   R V
Sbjct: 476 PLISGVQPSNPVYSGFQQYPQQYPGVNQLSSSIGGLSLQSSPQPESLRPV 525


>gi|33946282 hypothetical protein LOC25962 isoform 1 [Homo sapiens]
          Length = 1812

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 54/216 (25%), Positives = 82/216 (37%), Gaps = 27/216 (12%)

Query: 451 TNPTSPLLVKPSDLLEENKINSSVKFASGNTV-ADGYSSSDSFTSDPEQIGSNVTRQRSH 509
           + P++P+  +   L  E   N+S+ F   + V  DG      +      I  +V R  SH
Sbjct: 77  SKPSAPVFDRLGSL--EYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISH 134

Query: 510 SGTSPDNTAPPPPPPRPQPSHSRS---SSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQP 566
              SP    PPPPPP+PQPS  R+   +  +    F  +  + Q      PP  PP    
Sbjct: 135 DRDSPPPPPPPPPPPQPQPSLKRNPKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDD 194

Query: 567 SQAPGPAVHRPVDAD---------GLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDE 617
              P P    PV  D               S     +P++  ++D           V +E
Sbjct: 195 EDDPVPL---PVSGDKEEDAPHREDYFEPISPDRNSVPQEGQYSD--------EGEVEEE 243

Query: 618 QDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEK 653
           Q +E E+  + +  E+  D     R    DS  EE+
Sbjct: 244 QQEEGEEDEDDVDVEEEEDEDEDDR-RTVDSIPEEE 278



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 28/114 (24%), Positives = 43/114 (37%), Gaps = 12/114 (10%)

Query: 101  FVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQ--VKKGSVSHDTVQPRTSADAQ 158
            F   K++ E+   +S  S+       + V+PPP GRG+    +G   HD  + R    ++
Sbjct: 1589 FKLGKHKHETFITSSGKSEYIEPAKRAHVVPPPRGRGRGGFGQGIRPHDIFRQRKQNTSR 1648

Query: 159  EPA----------SPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWS 202
             P+          S  V PQ   P      +   +  S G       G G F S
Sbjct: 1649 PPSMHVDDFVAAESKEVVPQDGIPPPKRPLKVSQKISSRGGFSGNRGGRGAFHS 1702


>gi|33946280 hypothetical protein LOC25962 isoform 2 [Homo sapiens]
          Length = 1147

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 54/216 (25%), Positives = 82/216 (37%), Gaps = 27/216 (12%)

Query: 451 TNPTSPLLVKPSDLLEENKINSSVKFASGNTV-ADGYSSSDSFTSDPEQIGSNVTRQRSH 509
           + P++P+  +   L  E   N+S+ F   + V  DG      +      I  +V R  SH
Sbjct: 77  SKPSAPVFDRLGSL--EYDENTSIIFRPNSKVNTDGLVLRGWYNCLTLAIYGSVDRVISH 134

Query: 510 SGTSPDNTAPPPPPPRPQPSHSRS---SSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQP 566
              SP    PPPPPP+PQPS  R+   +  +    F  +  + Q      PP  PP    
Sbjct: 135 DRDSPPPPPPPPPPPQPQPSLKRNPKHADGEKEDQFNGSPPRPQPRGPRTPPGPPPPDDD 194

Query: 567 SQAPGPAVHRPVDAD---------GLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDE 617
              P P    PV  D               S     +P++  ++D           V +E
Sbjct: 195 EDDPVPL---PVSGDKEEDAPHREDYFEPISPDRNSVPQEGQYSD--------EGEVEEE 243

Query: 618 QDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEK 653
           Q +E E+  + +  E+  D     R    DS  EE+
Sbjct: 244 QQEEGEEDEDDVDVEEEEDEDEDDR-RTVDSIPEEE 278


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 70/335 (20%), Positives = 117/335 (34%), Gaps = 44/335 (13%)

Query: 395   EAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPT 454
             EAPP+K P +P   +  PE   +      V P  +   P K  ++E           +P 
Sbjct: 10743 EAPPAKVPEVPK--EVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPP 10800

Query: 455   SPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSP 514
               +  +P ++  E +I    +      VA+         + PE+    +  ++      P
Sbjct: 10801 PEVYEEPEEIAPEEEIAPEEE--KPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKP 10858

Query: 515   DNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAV 574
             +  APPP  P P+                          V   P + PRP P   P PA 
Sbjct: 10859 E--APPPKEPEPEK-------------------------VIEKPKLKPRPPP---PPPAP 10888

Query: 575   HRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKA 634
              +    + +    +   +++PE+P   +  +        V   +    +  PE  P  K 
Sbjct: 10889 PKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPL---KVPGGEKKVRKLLPERKPEPKE 10945

Query: 635   SDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHT 694
                  S+ + K   + E K        V K   P  PPPKPV      E+   P V +  
Sbjct: 10946 EVVLKSV-LRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPV------EEVEVPTVTKRE 10998

Query: 695   QKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNK 729
             +K      V   +P+IP    + K   +A ++  K
Sbjct: 10999 RKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 11033



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 49/222 (22%), Positives = 79/222 (35%), Gaps = 38/222 (17%)

Query: 514   PDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPA 573
             P+   P PPP +P+   ++   +           +++      P A+PP+P+      P 
Sbjct: 10534 PEKKVPVPPPKKPEVPPTKVPEVP-----KAAVPEKKV-----PEAIPPKPESPPPEVPE 10583

Query: 574   VHRPVDADGLI-----THTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAE----K 624
               + V  +  +          +P ++PE P        EV     V      + E    K
Sbjct: 10584 APKEVVPEKKVPAAPPKKPEVTPVKVPEAPK-------EVVPEKKVPVPPPKKPEVPPTK 10636

Query: 625   HPEV----LPAEK---ASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVR 677
              PEV    +P +K   A  P       +   + EE      PA V +   P APP   V 
Sbjct: 10637 VPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVP 10696

Query: 678   RRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKK 719
              +    ++  P V     K   L  V    P +P+ V  +KK
Sbjct: 10697 PKKPVPEKKAPAV---VAKKPELPPV--KVPEVPKEVVPEKK 10733



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 64/282 (22%), Positives = 99/282 (35%), Gaps = 65/282 (23%)

Query: 504  TRQRSHSGTSPDNTAPPPP----PPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPA 559
            + +R      P+  APPPP     P  +     S  ++  +       +    +V   P+
Sbjct: 9160 SHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPS 9219

Query: 560  -VPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQ 618
              P + +  +   PAVH             T    I E+         ++F AS+  +E 
Sbjct: 9220 RTPVQEEVIEVKVPAVH-------------TKKMVISEE---------KMFFASHTEEEV 9257

Query: 619  DDEAEKHPEVLPAEKASDPASSLRVAKTDSKTE--EKTAAS--APANVSKGTTPLAP--- 671
                 +  + +  E+    A S RV       E  EK A    AP  + K   P AP   
Sbjct: 9258 SVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVP 9317

Query: 672  --PPKPVRRRL------KSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQA 723
              P KPV          K E    P+V E  +K          +  IP  V K K+A  A
Sbjct: 9318 EVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKP-------VPEEKIPVPVAKKKEAPPA 9370

Query: 724  SIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRP 765
             +               E+Q+ +  V EE+I++  Q E+  P
Sbjct: 9371 KV--------------PEVQKGV--VTEEKITIVTQREESPP 9396



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 22/97 (22%), Positives = 40/97 (41%), Gaps = 5/97 (5%)

Query: 602  DFSQFEVFAASNVNDEQDDEAEKHPEVLPA--EKASDPASSLRVAKTDSKTEEKTAASAP 659
            D+ +FE +  +   D+ ++  E+  E      E  ++P   + V     +       + P
Sbjct: 9752 DYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPP 9811

Query: 660  ANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQK 696
            A V K   P    P P+ ++LK      P+V E  +K
Sbjct: 9812 AKVLKKAVPEEKVPVPIPKKLKPPP---PKVPEEPKK 9845


>gi|148806884 AKT1 substrate 1 (proline-rich) [Homo sapiens]
          Length = 256

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 67/250 (26%), Positives = 96/250 (38%), Gaps = 47/250 (18%)

Query: 517 TAPPPPPPRPQP----SHSRSSSLD-MNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPG 571
           TA PPPPPRP P    +H R +  +   R         +A   A PPA PP PQP  +P 
Sbjct: 32  TAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQP-PSPT 90

Query: 572 PAVHRPV-------DADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK 624
           P+  RP        + +   T T TS +Q+    N   F          V DE     + 
Sbjct: 91  PSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLF----------VMDE-----DA 135

Query: 625 HPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPK--PVRRRLKS 682
             + LP    SDP S+      D    E+T A  P       T   PP    P ++  KS
Sbjct: 136 TLQDLPPFCESDPEST-----DDGSLSEETPAGPP-------TCSVPPASALPTQQYAKS 183

Query: 683 EDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLA-----R 737
                P      ++T   ++   + P     + +   +++A + R  E   V       R
Sbjct: 184 LPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPR 243

Query: 738 LNSELQQQLK 747
           LN+   Q+LK
Sbjct: 244 LNTSDFQKLK 253


>gi|148806906 AKT1 substrate 1 (proline-rich) [Homo sapiens]
          Length = 256

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 67/250 (26%), Positives = 96/250 (38%), Gaps = 47/250 (18%)

Query: 517 TAPPPPPPRPQP----SHSRSSSLD-MNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPG 571
           TA PPPPPRP P    +H R +  +   R         +A   A PPA PP PQP  +P 
Sbjct: 32  TAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQP-PSPT 90

Query: 572 PAVHRPV-------DADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK 624
           P+  RP        + +   T T TS +Q+    N   F          V DE     + 
Sbjct: 91  PSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLF----------VMDE-----DA 135

Query: 625 HPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPK--PVRRRLKS 682
             + LP    SDP S+      D    E+T A  P       T   PP    P ++  KS
Sbjct: 136 TLQDLPPFCESDPEST-----DDGSLSEETPAGPP-------TCSVPPASALPTQQYAKS 183

Query: 683 EDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLA-----R 737
                P      ++T   ++   + P     + +   +++A + R  E   V       R
Sbjct: 184 LPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPR 243

Query: 738 LNSELQQQLK 747
           LN+   Q+LK
Sbjct: 244 LNTSDFQKLK 253


>gi|148806896 AKT1 substrate 1 (proline-rich) [Homo sapiens]
          Length = 256

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 67/250 (26%), Positives = 96/250 (38%), Gaps = 47/250 (18%)

Query: 517 TAPPPPPPRPQP----SHSRSSSLD-MNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPG 571
           TA PPPPPRP P    +H R +  +   R         +A   A PPA PP PQP  +P 
Sbjct: 32  TAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQP-PSPT 90

Query: 572 PAVHRPV-------DADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK 624
           P+  RP        + +   T T TS +Q+    N   F          V DE     + 
Sbjct: 91  PSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLF----------VMDE-----DA 135

Query: 625 HPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPK--PVRRRLKS 682
             + LP    SDP S+      D    E+T A  P       T   PP    P ++  KS
Sbjct: 136 TLQDLPPFCESDPEST-----DDGSLSEETPAGPP-------TCSVPPASALPTQQYAKS 183

Query: 683 EDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLA-----R 737
                P      ++T   ++   + P     + +   +++A + R  E   V       R
Sbjct: 184 LPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPR 243

Query: 738 LNSELQQQLK 747
           LN+   Q+LK
Sbjct: 244 LNTSDFQKLK 253


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 78/325 (24%), Positives = 120/325 (36%), Gaps = 57/325 (17%)

Query: 397  PPSKSPSMPSLNQTW--PELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPT 454
            P S+SPS P LN     P+  +S  ++++      R TP        +  R+GS     +
Sbjct: 1495 PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR-TPLG------QRSRSGS-----S 1542

Query: 455  SPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSP 514
              L VKPS   +E   + S   +   T       S S +S      S ++ +RS SG+SP
Sbjct: 1543 QELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSP 1602

Query: 515  D---------------NTAPPP--PPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHP 557
            +               +++P P  P PR  P  SRS S    R  +            HP
Sbjct: 1603 EVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP 1662

Query: 558  P-AVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQ-----IPEQPNFADFSQFEVFAA 611
            P +   R     +P P            T + T P++      PE    A  S+    A+
Sbjct: 1663 PKSRTARRGSRSSPEPK-----------TKSRTPPRRRSSRSSPELTRKARLSRRSRSAS 1711

Query: 612  SNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAP 671
            S+         E      P  + S   SS   A+    +  + +AS+P   +      +P
Sbjct: 1712 SS--------PETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSP 1763

Query: 672  PPKPVRRRLKSEDELRPEVDEHTQK 696
             PKP R   +S    R E    T++
Sbjct: 1764 SPKP-RGLQRSRSRSRREKTRTTRR 1787



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 48/206 (23%), Positives = 78/206 (37%), Gaps = 25/206 (12%)

Query: 375  EDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPS 434
            + SA    QP +   S S + +  S S S  S + +      SS D+            S
Sbjct: 2517 QPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSE----------GS 2566

Query: 435  KIHMQ-EMELKRTGSDHTNPTSPLLV----KPSDLLEENKINSSVKFASGNTVADGYSSS 489
             + +Q E+ LKR  S    P   +      +P+    + + +SS   +S ++ +   SSS
Sbjct: 2567 SLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSS 2626

Query: 490  DSFTSDPEQIGSNVTRQRSHSGTSPDNTAP-----PPPPPRPQPSHSRSSSLDMNRTFTV 544
             S +S      S+ +   S S  SP    P     P  P +P P   RS S         
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS-----PRKP 2681

Query: 545  TTGQQQAGVVAHPPAVPPRPQPSQAP 570
                + +  +++ P    RP P  +P
Sbjct: 2682 IDSLRDSRSLSYSPVERRRPSPQPSP 2707



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 52/244 (21%), Positives = 88/244 (36%), Gaps = 48/244 (19%)

Query: 505 RQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRP 564
           R+RS S T         P P+ + +H  +S+   + + T  +  + A    H  A+  R 
Sbjct: 245 RKRSRSTT---------PAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGR- 294

Query: 565 QPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK 624
               +P PA  R  + D   +   T+  Q P  P  A         +S   D+  D+ EK
Sbjct: 295 ----SPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQP-----SSPYEDKDKDKKEK 345

Query: 625 H-------------------PEVLPAEK--------ASDPASSLRVAKTD--SKTEEKTA 655
                               P  L AE+        A+ P S   V      S T +++ 
Sbjct: 346 SATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSP 405

Query: 656 ASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVG 715
             +P  + + ++  + PP P   ++       PE  +     G    + +S  S  RS G
Sbjct: 406 PKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHG 465

Query: 716 KDKK 719
           + K+
Sbjct: 466 RAKR 469



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 60/288 (20%), Positives = 105/288 (36%), Gaps = 39/288 (13%)

Query: 432 TPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSS--- 488
           TP +   +   L R G  H+          S    +NK  +S + +  N+  +   S   
Sbjct: 696 TPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRIS 755

Query: 489 ---SDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVT 545
              S S +S   +  S ++ +RS SG+SP        PPR     SRS            
Sbjct: 756 SRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR----RSRS------------ 799

Query: 546 TGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQ 605
            G  Q    +  P  P R + S +P P   +        +H+S+SP   P+  +     Q
Sbjct: 800 -GSSQPKAKSRTP--PRRSRSSSSPPP--KQKSKTPSRQSHSSSSPH--PKVKSGTPPRQ 852

Query: 606 FEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKG 665
                  ++   Q +E      V P  ++   +S     K+ + +    + S+P  V   
Sbjct: 853 ------GSITSPQANE----QSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSS 902

Query: 666 TTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRS 713
           T P   P +    + K +  + P    H+  +    + + S+ +  RS
Sbjct: 903 TPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRS 950



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 83/374 (22%), Positives = 128/374 (34%), Gaps = 63/374 (16%)

Query: 390  SGSPAEAPPSKSPSMPSLNQTWPELNQSS----EDTAIVHPVPIR--MTPSKIHMQEM-- 441
            S SP     SK+PS  S + + P     S       +I  P      +TP +    E   
Sbjct: 818  SSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSP 877

Query: 442  --ELK-RTGSDHT-NPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPE 497
              ELK RT S H+ + +SP  VK S    ++   SS        +      S S +S P 
Sbjct: 878  DPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPS 937

Query: 498  --QIGSNVTRQRS------------------HSGTS-PDNTAPPPPPPRPQPSHSRSSSL 536
              ++ S  T +RS                  HSG+S PD    P  PPR   SHS S S 
Sbjct: 938  PSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPR--QSHSGSISP 995

Query: 537  DMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPE 596
                      G   +G      +  P PQ           P    G ++  +      P 
Sbjct: 996  YPKVKAQTPPGPSLSG------SKSPCPQEKSKDSLVQSCP----GSLSLCAGVKSSTPP 1045

Query: 597  QPNFADFSQFEVFAASNV-----NDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTE 651
              ++   S  ++   S       +D    E  +     P+ ++    S        S   
Sbjct: 1046 GESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPV 1105

Query: 652  EKTAASAPANVSKGTTPLAPPPK----PVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQ 707
             + A+ +P    +G    +P  K    P + R +S+    P VD ++         L  Q
Sbjct: 1106 TELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNS---------LLGQ 1156

Query: 708  PSIPRSVGKDKKAI 721
              +  +  K+K A+
Sbjct: 1157 SRLETAESKEKMAL 1170


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 45/184 (24%), Positives = 66/184 (35%), Gaps = 18/184 (9%)

Query: 394  AEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNP 453
            A  PP  +  +P     +P L        +  P P+  +P+             SD + P
Sbjct: 1468 AAGPPGDACDIPP---PFPNLLPHRPPLLVFPPTPVTCSPA-------------SDES-P 1510

Query: 454  TSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTS 513
             +PL VK   +LE N +   V+    + ++  YS S     D            S   + 
Sbjct: 1511 LTPLEVKKLPVLETN-LKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASP 1569

Query: 514  PDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPA 573
            P    PPPPPP P P+  R  +              +AG  A  P V P+P  +   GP 
Sbjct: 1570 PSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPC 1629

Query: 574  VHRP 577
               P
Sbjct: 1630 SSFP 1633



 Score = 36.6 bits (83), Expect = 0.090
 Identities = 44/161 (27%), Positives = 59/161 (36%), Gaps = 27/161 (16%)

Query: 528  PSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHT 587
            P +S+S   D +R  +           A PP+ PP P P   P PA +RP        H 
Sbjct: 1540 PQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRP------CAHL 1593

Query: 588  STSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK-HPEVLPAEKASDPASSLRVAKT 646
            +  P+  P     A  S                EA K HP+   A  A   +S  ++  +
Sbjct: 1594 AFPPEPAPVNAGKAGPSA---------------EAPKVHPKPNSAPVAGPCSSFPKIPYS 1638

Query: 647  DSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSE-DEL 686
              K     A  A ++ S    P AP   P  R L S  DEL
Sbjct: 1639 PVKATRADARKAGSSAS----PPAPYSPPSSRPLSSPLDEL 1675


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 70/281 (24%), Positives = 106/281 (37%), Gaps = 57/281 (20%)

Query: 425  HPVPIRMTPSKI---HMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNT 481
            HP P++  P KI    + E E + T S   +P +PL   P+              +  ++
Sbjct: 1052 HPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPA--------------SGASS 1097

Query: 482  VADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRT 541
              D  S  DS  S P           S+       T P  P         RS+S+    +
Sbjct: 1098 TTDVCSVFDSDHSSPFH--------SSNDTVFIQVTLPHGP---------RSASVS---S 1137

Query: 542  FTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFA 601
             ++T G  +  V   PP VPPR +P  AP  +    +    +  H  + P   P QP   
Sbjct: 1138 ISLTKGTDEVPV---PPPVPPRRRPESAPAESSPSKI----MSKHLDSPPAIPPRQPTSK 1190

Query: 602  DFS-QFEVFAASNVNDEQDDEAEKHPEVLPAEKASDP----ASSLRVAKTD-SKTEEKTA 655
             +S ++ +   ++++    D  E  P + P E    P    +S L +      K  +   
Sbjct: 1191 AYSPRYSISDRTSIS----DPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGN 1246

Query: 656  ASAPANVSKGT--TPLAPPPKPVRRRLKSEDELRPEVDEHT 694
            A  P + S  T   P  P P   RR L S   L  EVD H+
Sbjct: 1247 AFFPNSPSPFTPPPPQTPSPHGTRRHLPS-PPLTQEVDLHS 1286



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 48/225 (21%), Positives = 76/225 (33%), Gaps = 45/225 (20%)

Query: 364  PESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAI 423
            P S     I L    D    P  V     P  AP   SPS              S+    
Sbjct: 1130 PRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPS-----------KIMSKHLDS 1178

Query: 424  VHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVA 483
               +P R   SK +     +    S    P SP L+ P + +                  
Sbjct: 1179 PPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVR----------------- 1221

Query: 484  DGYSSSDSFTSDPEQIGSNVTRQRSHSGTS--PDNTAP--PPPPPRPQPSHSR------- 532
                + D F+S P  +      ++S  G +  P++ +P  PPPP  P P  +R       
Sbjct: 1222 ----TPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPP 1277

Query: 533  -SSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHR 576
             +  +D++         +Q+    H P +PP+    +   P++HR
Sbjct: 1278 LTQEVDLHSIAGPPVPPRQS-TSQHIPKLPPKTYKREHTHPSMHR 1321



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 22/69 (31%), Positives = 28/69 (40%), Gaps = 6/69 (8%)

Query: 132  PPPGRGQVKKGSVSHDTVQPRTS-ADAQEPASPVVSPQQS-----PPTSPHTWRKHSRHP 185
            PPP +     G+  H    P T   D    A P V P+QS     P   P T+++   HP
Sbjct: 1258 PPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHP 1317

Query: 186  SGGNSERPL 194
            S      PL
Sbjct: 1318 SMHRDGPPL 1326


>gi|112382214 SEC24 (S. cerevisiae) homolog B isoform b [Homo
           sapiens]
          Length = 1233

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 58/223 (26%), Positives = 81/223 (36%), Gaps = 41/223 (18%)

Query: 377 SADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEDTAIVHPVPIRMTPSKI 436
           S   GD  G++  S +     P K  S             S ++TAI HP P+   PS+ 
Sbjct: 200 SLPAGDTYGQMFTSQNAPTVRPVKDNSF------------SGQNTAISHPSPLPPLPSQQ 247

Query: 437 HMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGN---TVADGYSSSDSFT 493
           H Q+  L  +G      +SP L    D L  N    S+  A+ N   TVAD  S      
Sbjct: 248 HHQQQSL--SGYSTLTWSSPGLPSTQDNLIRNH-TGSLAVANNNPTITVADSLSCPVMQN 304

Query: 494 SDPEQIGSNVTRQRSHSGTSPDNTAPP-------PPPPRPQPSH-----------SRSSS 535
             P +    V+   S S  S     PP       P     QPS            + SS+
Sbjct: 305 VQPPKSSPVVSTVLSGSSGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVDSSSTTSSA 364

Query: 536 LDMNRTFTVTTGQQQAGVVAHPPAVP-----PRPQPSQAPGPA 573
             M  ++    G     +++   + P     P P P+ AP PA
Sbjct: 365 SPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAPA 407



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 17/141 (12%)

Query: 445 RTGSDHTNPTSPL--LVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSN 502
           RT     +P  P+  + +PS+LL++  ++SS   +S + + + Y + +   S P+ + S+
Sbjct: 328 RTPPTANHPVEPVTSVTQPSELLQQKGVDSSSTTSSASPMPNSYDALEG-GSYPDMLSSS 386

Query: 503 VTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTF-----TVTTGQQQAGVVAHP 557
            +         PD  + P P   P P   + S   M + F     T+  G Q A      
Sbjct: 387 ASSPAPDPAPEPDPASAPAPASAPAPVVPQPSK--MAKPFGYGYPTLQPGYQNATAPLIS 444

Query: 558 PAVPPRP-------QPSQAPG 571
              P  P        P Q PG
Sbjct: 445 GVQPSNPVYSGFQQYPQQYPG 465


>gi|223972704 hypothetical protein LOC284418 [Homo sapiens]
          Length = 922

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 71/273 (26%), Positives = 103/273 (37%), Gaps = 35/273 (12%)

Query: 501 SNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAH---- 556
           S++ R R  +G    +  P PPP +  PS   +S       F V   Q+   V A     
Sbjct: 376 SSIPRGREKAGPMGSHQGPGPPPCQKAPSGLVTS---CKAPFLVDQSQKLPAVPASSWKP 432

Query: 557 -PPAVPPRPQP-SQAP---GPAVHRPVDADGLITHTSTSPQQIP---EQPNFADFSQFEV 608
            P   PP+  P + AP    PAV  P      +   S     IP    + + A  S  + 
Sbjct: 433 PPGLAPPQKAPAASAPPRKAPAVPAPSQKAPAVPAPSQKAPAIPAPSRKASAASASPRKA 492

Query: 609 FAASNVNDEQDDEAEKHPEV--LPAEKASD----------PASSLRVAKTDSKTEEKTAA 656
            A      +    ++K P V  +P +  S           PA S +   T S TE + A 
Sbjct: 493 SAVPAPPQKTPPPSQKAPSVPTIPQKAVSPTAPKKKSLLLPAPSQKALPT-SPTEYQMAL 551

Query: 657 SAPANVSK-----GTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVL-AAVLASQPSI 710
           S PA+  K        P   P + V  R +S  +  P V   TQ+T V+     A  P  
Sbjct: 552 SPPASRGKLPGDFDVLPTGIPGRAVLERSQSGGKPEPVVTVRTQETDVVEMTTQAKSPES 611

Query: 711 PRSVGKDKKAIQASIRRNKETNTVLARLNSELQ 743
           P +V K K++    I + KE      R   +L+
Sbjct: 612 PFTVTK-KESKDILISQTKEVTLEAFRGQGKLE 643


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 55/204 (26%), Positives = 72/204 (35%), Gaps = 39/204 (19%)

Query: 151 PRTSADAQEPASPVVSP---QQSPPTSPHTWRKHSRHPSG---GNSERPLAGPGPFWSPF 204
           P  S + + PA P VSP   +  PP SP  W+ +    SG        P   PGP W P 
Sbjct: 294 PAVSPEPRRPA-PAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGP-WKPI 351

Query: 205 GEAQSG-----SSAGDAVW--------SGHSPPPPQENWVSFADTPP-----TSTLLTMH 246
                G      S   A W        S  SPP   E+W S    PP       TL   H
Sbjct: 352 PSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKS---GPPELRKTAPTLSPEH 408

Query: 247 PASVQDQTTVRTVASATTAIEIR--------RQSSSYDDPWKITDEQRQYYVN--QFKTI 296
             +V   +          + EIR        R+ S   D WK++ +QR+       F   
Sbjct: 409 WKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPES 468

Query: 297 QPDLNGFIPGSAAKEFFTKSKLPI 320
           Q    G  P      FF + + P+
Sbjct: 469 QKSSRGGSPDLWKSSFFIEPQKPV 492



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 41/167 (24%), Positives = 56/167 (33%), Gaps = 40/167 (23%)

Query: 506 QRSHSGTSPDNTAPPPP-PPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRP 564
           +R     SP +  P PP  PRP  S+  +SS                      P  P +P
Sbjct: 301 RRPAPAVSPGSWKPGPPGSPRPWKSNPSASS---------------------GPWKPAKP 339

Query: 565 QPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEK 624
            PS +PGP   +P+         S SP      P+        V +AS  +      + K
Sbjct: 340 APSVSPGP--WKPI--------PSVSPGPWKPTPS--------VSSASWKSSSVSPSSWK 381

Query: 625 HPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAP 671
            P   P    S P    + A T S    K        + K   PL+P
Sbjct: 382 SPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSP 428



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 34/156 (21%), Positives = 54/156 (34%), Gaps = 16/156 (10%)

Query: 521 PPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVP-PRPQPSQAPGPAVHRPVD 579
           P  P+P P              T    Q+   VV+     P P P+PS+    +   P  
Sbjct: 143 PESPKPTP-------------LTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPK 189

Query: 580 ADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPAS 639
           +  +      +P   PE    A  S   V A   +++ +  +    PE L    AS P S
Sbjct: 190 SVPVCESQKLAPVPSPEPQKPAPVSPESVKAT--LSNPKPQKQSHFPETLGPPSASSPES 247

Query: 640 SLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKP 675
            +  A  +       A+      ++ T+P    P P
Sbjct: 248 PVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSP 283


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,170,598
Number of Sequences: 37866
Number of extensions: 2149150
Number of successful extensions: 21984
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 945
Number of HSP's that attempted gapping in prelim test: 15305
Number of HSP's gapped (non-prelim): 5822
length of query: 769
length of database: 18,247,518
effective HSP length: 110
effective length of query: 659
effective length of database: 14,082,258
effective search space: 9280208022
effective search space used: 9280208022
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.