Search of human proteins with 190684677

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
         (1514 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190684677 mitogen-activated protein kinase binding protein 1 ...  3030   0.0  
gi|190684671 mitogen-activated protein kinase binding protein 1 ...  3011   0.0  
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]            1027   0.0  
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]            1026   0.0  
gi|223005862 echinoderm microtubule associated protein like 6 [H...   100   1e-20
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H...    80   1e-14
gi|34485720 echinoderm microtubule associated protein like 5 [Ho...    80   2e-14
gi|26665869 WD repeat domain 51B [Homo sapiens]                        77   1e-13
gi|32189425 WD repeat domain 69 [Homo sapiens]                         77   1e-13
gi|56790932 echinoderm microtubule associated protein like 1 iso...    72   5e-12
gi|56790930 echinoderm microtubule associated protein like 1 iso...    72   5e-12
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    68   8e-11
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             67   1e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             67   1e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             67   1e-10
gi|223029510 echinoderm microtubule associated protein like 4 is...    67   1e-10
gi|19923497 echinoderm microtubule associated protein like 4 iso...    67   1e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    67   2e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    67   2e-10
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    65   4e-10
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    65   4e-10
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    65   4e-10
gi|6912356 echinoderm microtubule associated protein like 2 [Hom...    65   4e-10
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    65   4e-10
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    65   4e-10
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     65   6e-10
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]              64   8e-10
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]              64   8e-10
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]              64   8e-10
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    64   1e-09

>gi|190684677 mitogen-activated protein kinase binding protein 1
            isoform b [Homo sapiens]
          Length = 1514

 Score = 3030 bits (7855), Expect = 0.0
 Identities = 1514/1514 (100%), Positives = 1514/1514 (100%)

Query: 1    MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60
            MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
Sbjct: 1    MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60

Query: 61   SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD 120
            SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
Sbjct: 61   SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD 120

Query: 121  VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180
            VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
Sbjct: 121  VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180

Query: 181  TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
            TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
Sbjct: 181  TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240

Query: 241  RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG 300
            RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
Sbjct: 241  RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG 300

Query: 301  TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS 360
            TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
Sbjct: 301  TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS 360

Query: 361  CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD 420
            CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
Sbjct: 361  CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD 420

Query: 421  NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV 480
            NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
Sbjct: 421  NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV 480

Query: 481  GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA 540
            GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
Sbjct: 481  GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA 540

Query: 541  SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK 600
            SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
Sbjct: 541  SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK 600

Query: 601  SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE 660
            SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
Sbjct: 601  SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE 660

Query: 661  DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS 720
            DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
Sbjct: 661  DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS 720

Query: 721  VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG 780
            VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
Sbjct: 721  VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG 780

Query: 781  PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF 840
            PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
Sbjct: 781  PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF 840

Query: 841  LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH 900
            LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
Sbjct: 841  LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH 900

Query: 901  GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS 960
            GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
Sbjct: 901  GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS 960

Query: 961  DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES 1020
            DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
Sbjct: 961  DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES 1020

Query: 1021 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA 1080
            TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
Sbjct: 1021 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA 1080

Query: 1081 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN 1140
            APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
Sbjct: 1081 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN 1140

Query: 1141 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH 1200
            GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
Sbjct: 1141 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH 1200

Query: 1201 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR 1260
            SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
Sbjct: 1201 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR 1260

Query: 1261 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR 1320
            SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
Sbjct: 1261 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR 1320

Query: 1321 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ 1380
            APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
Sbjct: 1321 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ 1380

Query: 1381 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV 1440
            GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
Sbjct: 1381 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV 1440

Query: 1441 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE 1500
            AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
Sbjct: 1441 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE 1500

Query: 1501 LLLRAVERRMERKL 1514
            LLLRAVERRMERKL
Sbjct: 1501 LLLRAVERRMERKL 1514


>gi|190684671 mitogen-activated protein kinase binding protein 1
            isoform a [Homo sapiens]
          Length = 1508

 Score = 3011 bits (7807), Expect = 0.0
 Identities = 1508/1514 (99%), Positives = 1508/1514 (99%), Gaps = 6/1514 (0%)

Query: 1    MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60
            MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
Sbjct: 1    MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60

Query: 61   SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD 120
            SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
Sbjct: 61   SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD 120

Query: 121  VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180
            VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
Sbjct: 121  VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180

Query: 181  TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
            TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
Sbjct: 181  TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240

Query: 241  RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG 300
            RGKKADSTFCITSSGLLCEFSDRRLLDKWVELR      TTVAHCISVSQDYIFCGCADG
Sbjct: 241  RGKKADSTFCITSSGLLCEFSDRRLLDKWVELR------TTVAHCISVSQDYIFCGCADG 294

Query: 301  TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS 360
            TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
Sbjct: 295  TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS 354

Query: 361  CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD 420
            CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
Sbjct: 355  CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD 414

Query: 421  NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV 480
            NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
Sbjct: 415  NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV 474

Query: 481  GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA 540
            GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
Sbjct: 475  GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA 534

Query: 541  SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK 600
            SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
Sbjct: 535  SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK 594

Query: 601  SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE 660
            SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
Sbjct: 595  SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE 654

Query: 661  DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS 720
            DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
Sbjct: 655  DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS 714

Query: 721  VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG 780
            VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
Sbjct: 715  VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG 774

Query: 781  PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF 840
            PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
Sbjct: 775  PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF 834

Query: 841  LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH 900
            LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
Sbjct: 835  LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH 894

Query: 901  GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS 960
            GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
Sbjct: 895  GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS 954

Query: 961  DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES 1020
            DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
Sbjct: 955  DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES 1014

Query: 1021 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA 1080
            TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
Sbjct: 1015 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA 1074

Query: 1081 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN 1140
            APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
Sbjct: 1075 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN 1134

Query: 1141 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH 1200
            GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
Sbjct: 1135 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH 1194

Query: 1201 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR 1260
            SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
Sbjct: 1195 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR 1254

Query: 1261 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR 1320
            SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
Sbjct: 1255 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR 1314

Query: 1321 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ 1380
            APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
Sbjct: 1315 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ 1374

Query: 1381 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV 1440
            GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
Sbjct: 1375 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV 1434

Query: 1441 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE 1500
            AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
Sbjct: 1435 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE 1494

Query: 1501 LLLRAVERRMERKL 1514
            LLLRAVERRMERKL
Sbjct: 1495 LLLRAVERRMERKL 1508


>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
          Length = 1518

 Score = 1027 bits (2655), Expect = 0.0
 Identities = 650/1571 (41%), Positives = 894/1571 (56%), Gaps = 172/1571 (10%)

Query: 18   SPSIKLRRSK--AGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLF 75
            +P I LRR    +    E + ++V+LEKVLGIT     GL CDP +G VAY AGCVVV+ 
Sbjct: 37   APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVIL 96

Query: 76   NPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKY 135
            +P+++KQ HI N++RK+++ALAFSPDGKY+VTGE+GH PAVR+WDV E +QVAE+  HKY
Sbjct: 97   DPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKY 156

Query: 136  GVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 195
            GVACVAFSP+ K+IVS+GYQHDM++NVW WKK+IVVASNKVS RV A+SFSED SYFVT 
Sbjct: 157  GVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTV 216

Query: 196  GNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSG 255
            GNRH++FW+L+ S  +KV +TVPL+GRSG+LGEL NN+F  VACGRG+ A STFC++ SG
Sbjct: 217  GNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSG 276

Query: 256  LLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLST 315
            LLC+F+++R+L+KW+ L+       +++ C+ VSQ+ IFCGC DG VR+F   +LH+L+ 
Sbjct: 277  LLCQFNEKRVLEKWINLK------VSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLAN 330

Query: 316  LPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRD 375
            LP+PH LG D+A   E S LF   A A YPDT+ALTFDP +QWLSCVY DHSIY+WDV+D
Sbjct: 331  LPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKD 390

Query: 376  PKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHG 435
              +VGKV+S L+HSS VW+VEVYPE +D  +ACLP  SF+TCSSDNTIR WN +SS    
Sbjct: 391  INRVGKVWSELFHSSYVWNVEVYPEFED-QRACLPSGSFLTCSSDNTIRFWNLDSS--PD 447

Query: 436  STLHRNILSSDLIKIIYVDGNTQALLD-TELPGGDKADASLLDPRVGIRSVCVSPNGQHL 494
            S   +NI S+ L+K++YV+ + Q L D +  P     + + +D + G+R + VSP+GQHL
Sbjct: 448  SHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHL 507

Query: 495  ASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAG 554
            ASGDR G LR+HEL  + E++KVEAHD+E+LCLEYSKP+TGL LLASASRDRLIHVL+  
Sbjct: 508  ASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVE 567

Query: 555  REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVV 614
            + Y+L+QTLD+HSSSITA+KF A +  ++MISCGADKSIYFR+AQ+  DG+ F RTHHV 
Sbjct: 568  KNYNLEQTLDDHSSSITAIKF-AGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVA 626

Query: 615  RKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGI 674
             KTTLYDMD++ + KY A+ CQDRN+R++N  +GKQKK +KGSQG++G+L+KV  DPSG 
Sbjct: 627  EKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGT 686

Query: 675  YIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
            ++ATSCSDK++S+ DF SGEC+A MFGHSEI+T MKF+ DC HLI+VSGDSC+F+W L  
Sbjct: 687  FLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGP 746

Query: 735  EMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDE 794
            E+T  M+Q L E+  RQ   +QQ  +  +R+  P +    + +S    + S S  E  ++
Sbjct: 747  EITNCMKQHLLEIDHRQ---QQQHTNDKKRSGHPRQ---DTYVSTPSEIHSLSPGEQTED 800

Query: 795  GTEEELPALPVLAKSTKKALASVPSPALPR-SLSHWEMSRAQESVGFLDPAPA----ANP 849
              EEE     +L   +K +L   P   L    L  W    A+  +G  D A      A  
Sbjct: 801  DLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLW----AKRLLGDDDVADGLAFHAKR 856

Query: 850  GPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSL 909
              +  GRW +   +  ++++LD + L+     ++  S ++  +    P+         SL
Sbjct: 857  SYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQS------LASL 910

Query: 910  TSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYP-EPSDNPTMDTS 968
             S++E P       P   P       Q+E   A +L        I+Y  E     T   S
Sbjct: 911  LSESESPQEAGRGHPSFLP------QQKESSEASEL--------ILYSLEAEVTVTGTDS 956

Query: 969  EF---QVQAPARGTLGRVY-------PGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDS 1018
            ++   +V+A      G  Y       P  +S  + S +S   ++ S + + SP  P + +
Sbjct: 957  QYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPA 1016

Query: 1019 ESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLAS 1078
                       +S    P      E+E     GP       PQTP+QE+FL+ HFETL  
Sbjct: 1017 PRF-------ATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTE 1069

Query: 1079 GAAPGAPVQVPERSESR--------SISSRFL--LQVQTRPLREPSPSSSSLALMSRPAQ 1128
              +P   +   E SE+         SIS++FL  LQ  +R      P ++   + S   +
Sbjct: 1070 --SPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVK 1127

Query: 1129 VPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATAS 1188
            +    G QPR                +G  SP +   VL          +W P      S
Sbjct: 1128 LMDRGGSQPRA--------------GTGYASPDR-THVLAAGKAEETLEAWRPPPPCLTS 1172

Query: 1189 PFSGLQKAQSVHSLVPQERH-EASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSY 1247
                L       S++P +R+      AP+PG  L++ + A             PS   SY
Sbjct: 1173 ----LASCVPASSVLPTDRNLPTPTSAPTPG--LAQGVHA-------------PS-TCSY 1212

Query: 1248 QNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLA-LPSRAHLVLDIPKPLPD 1306
               T SS A+ISRSIS+G++ G +    A    R S + +LA L      +     P  D
Sbjct: 1213 MEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLD 1272

Query: 1307 ----RPTLAAFS--------PVTKGRA------PGEAEKPG--FPVGLGKAHSTTERWAC 1346
                 P L ++          +T   A      P    +PG   P     A S  E  A 
Sbjct: 1273 SEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESAL 1332

Query: 1347 LGEGTTPKPRTECQAHPG-PSSPCAQQLPVSSLFQGPENLQPPPPEKTPNPMECTKPGAA 1405
               G+  +P       PG P+ P   QLP           +P  P  T + +E T     
Sbjct: 1333 RLHGSAFRPSLPAPESPGLPAHPSNPQLP---------EARPGIPGGTASLLEPTSGALG 1383

Query: 1406 LSQD-----SEPAVSLE----------QCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQ 1450
            L Q      SEP V +E          +   ++  L+ + ++A+ LY  +         Q
Sbjct: 1384 LLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQ 1443

Query: 1451 SRIAQLLRDTFSSVRQELEA-------VAGA-VLSSPG-SSPGA---VGAEQTQALLEQY 1498
             +    L  TF  +  +LEA       VA A  L SPG  SP     + +   QALLE Y
Sbjct: 1444 QQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHY 1503

Query: 1499 SELLLRAVERR 1509
            SELL++AV R+
Sbjct: 1504 SELLVQAVRRK 1514


>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
          Length = 1523

 Score = 1026 bits (2652), Expect = 0.0
 Identities = 652/1575 (41%), Positives = 894/1575 (56%), Gaps = 175/1575 (11%)

Query: 18   SPSIKLRRSK--AGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLF 75
            +P I LRR    +    E + ++V+LEKVLGIT     GL CDP +G VAY AGCVVV+ 
Sbjct: 37   APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVIL 96

Query: 76   NPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKY 135
            +P+++KQ HI N++RK+++ALAFSPDGKY+VTGE+GH PAVR+WDV E +QVAE+  HKY
Sbjct: 97   DPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKY 156

Query: 136  GVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 195
            GVACVAFSP+ K+IVS+GYQHDM++NVW WKK+IVVASNKVS RV A+SFSED SYFVT 
Sbjct: 157  GVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTV 216

Query: 196  GNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSG 255
            GNRH++FW+L+ S  +KV +TVPL+GRSG+LGEL NN+F  VACGRG+ A STFC++ SG
Sbjct: 217  GNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSG 276

Query: 256  LLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLST 315
            LLC+F+++R+L+KW+ L+       +++ C+ VSQ+ IFCGC DG VR+F   +LH+L+ 
Sbjct: 277  LLCQFNEKRVLEKWINLK------VSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLAN 330

Query: 316  LPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRD 375
            LP+PH LG D+A   E S LF   A A YPDT+ALTFDP +QWLSCVY DHSIY+WDV+D
Sbjct: 331  LPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKD 390

Query: 376  PKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHG 435
              +VGKV+S L+HSS VW+VEVYPE +D  +ACLP  SF+TCSSDNTIR WN +SS    
Sbjct: 391  INRVGKVWSELFHSSYVWNVEVYPEFED-QRACLPSGSFLTCSSDNTIRFWNLDSS--PD 447

Query: 436  STLHRNILSSDLIKIIYVDGNTQALLD-TELPGGDKADASLLDPRVGIRSVCVSPNGQHL 494
            S   +NI S+ L+K++YV+ + Q L D +  P     + + +D + G+R + VSP+GQHL
Sbjct: 448  SHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHL 507

Query: 495  ASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAG 554
            ASGDR G LR+HEL  + E++KVEAHD+E+LCLEYSKP+TGL LLASASRDRLIHVL+  
Sbjct: 508  ASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVE 567

Query: 555  REYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVV 614
            + Y+L+QTLD+HSSSITA+KF A +  ++MISCGADKSIYFR+AQ+  DG+ F RTHHV 
Sbjct: 568  KNYNLEQTLDDHSSSITAIKF-AGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVA 626

Query: 615  RKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGI 674
             KTTLYDMD++ + KY A+ CQDRN+R++N  +GKQKK +KGSQG++G+L+KV  DPSG 
Sbjct: 627  EKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGT 686

Query: 675  YIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
            ++ATSCSDK++S+ DF SGEC+A MFGHSEI+T MKF+ DC HLI+VSGDSC+F+W L  
Sbjct: 687  FLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGP 746

Query: 735  EMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDE 794
            E+T  M+Q L E+  RQ   +QQ  +  +R+  P +    + +S    + S S  E  ++
Sbjct: 747  EITNCMKQHLLEIDHRQ---QQQHTNDKKRSGHPRQ---DTYVSTPSEIHSLSPGEQTED 800

Query: 795  GTEEELPALPVLAKSTKKALASVPSPALPR-SLSHWEMSRAQESVGFLDPAPA----ANP 849
              EEE     +L   +K +L   P   L    L  W    A+  +G  D A      A  
Sbjct: 801  DLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLW----AKRLLGDDDVADGLAFHAKR 856

Query: 850  GPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSL 909
              +  GRW +   +  ++++LD + L+     ++  S ++  +    P+         SL
Sbjct: 857  SYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQS------LASL 910

Query: 910  TSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYP-EPSDNPTMDTS 968
             S++E P       P   P       Q+E   A +L        I+Y  E     T   S
Sbjct: 911  LSESESPQEAGRGHPSFLP------QQKESSEASEL--------ILYSLEAEVTVTGTDS 956

Query: 969  EF---QVQAPARGTLGRVY-------PGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDS 1018
            ++   +V+A      G  Y       P  +S  + S +S   ++ S + + SP  P + +
Sbjct: 957  QYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPA 1016

Query: 1019 ESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLAS 1078
                       +S    P      E+E     GP       PQTP+QE+FL+ HFETL  
Sbjct: 1017 PRF-------ATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTE 1069

Query: 1079 GAA----PGAPVQVPERSESR--------SISSRFL--LQVQTRPLREPSPSSSSLALMS 1124
                   P A   V E SE+         SIS++FL  LQ  +R      P ++   + S
Sbjct: 1070 SPCRELFPAALGDV-EASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKS 1128

Query: 1125 RPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRV 1184
               ++    G QPR                +G  SP +   VL          +W P   
Sbjct: 1129 PEVKLMDRGGSQPRA--------------GTGYASPDR-THVLAAGKAEETLEAWRPPPP 1173

Query: 1185 ATASPFSGLQKAQSVHSLVPQERH-EASLQAPSPGALLSREIEAQDGLGSLPPADGRPSR 1243
               S    L       S++P +R+      AP+PG  L++ + A             PS 
Sbjct: 1174 CLTS----LASCVPASSVLPTDRNLPTPTSAPTPG--LAQGVHA-------------PS- 1213

Query: 1244 PHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLA-LPSRAHLVLDIPK 1302
              SY   T SS A+ISRSIS+G++ G +    A    R S + +LA L      +     
Sbjct: 1214 TCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATT 1273

Query: 1303 PLPD----RPTLAAFS--------PVTKGRA------PGEAEKPG--FPVGLGKAHSTTE 1342
            P  D     P L ++          +T   A      P    +PG   P     A S  E
Sbjct: 1274 PSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVE 1333

Query: 1343 RWACLGEGTTPKPRTECQAHPG-PSSPCAQQLPVSSLFQGPENLQPPPPEKTPNPMECTK 1401
              A    G+  +P       PG P+ P   QLP           +P  P  T + +E T 
Sbjct: 1334 ESALRLHGSAFRPSLPAPESPGLPAHPSNPQLP---------EARPGIPGGTASLLEPTS 1384

Query: 1402 PGAALSQD-----SEPAVSLE----------QCEQLVAELRGSVRQAVRLYHSVAGCKMP 1446
                L Q      SEP V +E          +   ++  L+ + ++A+ LY  +      
Sbjct: 1385 GALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQV 1444

Query: 1447 SAEQSRIAQLLRDTFSSVRQELEA-------VAGA-VLSSPG-SSPGA---VGAEQTQAL 1494
               Q +    L  TF  +  +LEA       VA A  L SPG  SP     + +   QAL
Sbjct: 1445 DTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQAL 1504

Query: 1495 LEQYSELLLRAVERR 1509
            LE YSELL++AV R+
Sbjct: 1505 LEHYSELLVQAVRRK 1519


>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
           sapiens]
          Length = 1958

 Score =  100 bits (249), Expect = 1e-20
 Identities = 171/772 (22%), Positives = 291/772 (37%), Gaps = 164/772 (21%)

Query: 64  VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
           V Y    V V++N R+H Q   L  +   I +LA  PD   + TG+ G  P + +WD   
Sbjct: 36  VVYFVAGVGVVYNTREHSQKFFLGHN-DDIISLALHPDKTLVATGQVGKEPYICIWDSYN 94

Query: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVAS-NKVSSRVT 181
              V+ L++ H +GVAC+AF    + + SVG      V +W W+K  ++AS    S R+ 
Sbjct: 95  VQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIF 154

Query: 182 AVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
            +S+     +  V+ G +HIKFW L        NA     G  G  G+L+      + C 
Sbjct: 155 DISWDPYQPNRVVSCGVKHIKFWTLCG------NALTAKRGIFGKTGDLQT-----ILCL 203

Query: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG 300
              K D T+    +G +  +    L      +R I    +     +   ++    G  DG
Sbjct: 204 ACAKEDITYSGALNGDIYVWKGLNL------VRTIQGAHSAGIFSMYACEEGFATGGRDG 257

Query: 301 TVRL----FNPSNLHFLSTLPRPHALGTDIASVT-EASRLFSGVANARYPDTIALTFDPT 355
            +RL    F P     L    + +  G  I SV  +A RL +G                 
Sbjct: 258 CIRLWDTDFKPITKIDLRETEQGYK-GLSIRSVCWKADRLLAGT---------------- 300

Query: 356 NQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFI 415
                    D  I+   VR+  K   +    +    +W++ ++P+              +
Sbjct: 301 --------QDSEIFEVIVRERDKPMLILQG-HCEGELWALALHPK----------KPLAV 341

Query: 416 TCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASL 475
           T S D ++RLW+                                         D A  + 
Sbjct: 342 TGSDDRSVRLWSL---------------------------------------ADHALIAR 362

Query: 476 LDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTG 535
            +    +RSV  SP+G  LA G + G+  V  ++ ++E++ ++     I  +++S PD  
Sbjct: 363 CNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFS-PDG- 420

Query: 536 LKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYF 595
              LA  S D  + V    + Y       +  S IT + ++  D +    + GA + +++
Sbjct: 421 -SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSL-DSKYLQTNDGAGERLFY 478

Query: 596 R-------TAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISS 647
           R       T+++   G+ +         T +   +V   W KYT +   D N    N +S
Sbjct: 479 RMPSGKPLTSKEEIKGIPWASW------TCVKGPEVSGIWPKYTEV--TDINSVDANYNS 530

Query: 648 GKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVT 707
                      G+D  L+K+   P                     G       GHS  VT
Sbjct: 531 SVL------VSGDDFGLVKLFKFPC-----------------LKRGAKFRKYVGHSAHVT 567

Query: 708 GMKFSNDCKHLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRAS 766
            +++S+D + ++S  G D  +F WR   E    +   + E   ++ G             
Sbjct: 568 NVRWSHDFQWVLSTGGADHSVFQWRFIPE---GVSNGMLETAPQEGGADSYS-------- 616

Query: 767 GPNRHQAPSMLSPGPALSSDSDKEG----EDEGTEEELPALPVLAKSTKKAL 814
                ++ S LS  P L SD ++E     + +  +E+LP L   +K    A+
Sbjct: 617 ----EESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEKNHAV 664



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 128/558 (22%), Positives = 214/558 (38%), Gaps = 98/558 (17%)

Query: 49   VSGGRGLACD-----PRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
            + G RG  C       ++G V Y    V V++N ++H Q   L      I +L   P   
Sbjct: 682  IHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHD-DDILSLTIHPVKD 740

Query: 104  YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
            Y+ TG+ G   A+ VWD      ++ L+ +H+ GV  + FS   K +VSVG      +  
Sbjct: 741  YVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVF 800

Query: 163  WAWKKNIVVASNK-VSSRVTAVSFS-EDCSYFVTAGNRHIKFW-YLDDSKTSKVNATVPL 219
            W WKK   +A+ +    ++  V  +       VT G +HIKFW       TSK       
Sbjct: 801  WDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSK------- 853

Query: 220  LGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFT 279
             G  G +G+L     T +    G+  D  F   ++G +  + D  L      L+ + +  
Sbjct: 854  RGTFGSVGKLE----TMMCVSYGRMEDLVFSGAATGDIFIWKDILL------LKTVKAHD 903

Query: 280  TTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGV 339
              V    ++ + ++  G  DG V L++      L T    +A+     S +       G+
Sbjct: 904  GPVFAMYALDKGFV-TGGKDGIVELWDDMFERCLKT----YAIKRSALSTSS-----KGL 953

Query: 340  ANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSAL--YHSSCVWSVEV 397
                 P   A+T    +  +            ++ +  K G +   +  +    VW +  
Sbjct: 954  LLEDNPSIRAITLGHGHILVGTKNG-------EILEIDKSGPMTLLVQGHMEGEVWGLAA 1006

Query: 398  YPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNT 457
            +P         LP  +  T S D T+R+W         S  HR +    L K        
Sbjct: 1007 HP--------LLPICA--TVSDDKTLRIWEL-------SAQHRMLAVRKLKK-------- 1041

Query: 458  QALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKV 517
                                   G R    SP+G+ LA G   G+  V    ++ +M+  
Sbjct: 1042 -----------------------GGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSF 1078

Query: 518  EAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAA 577
                  I  +++SK DTG K LA AS D  + + +      +       SS IT + +  
Sbjct: 1079 HHRKEMISDIKFSK-DTG-KYLAVASHDNFVDIYNVLTSKRV-GICKGASSYITHIDW-D 1134

Query: 578  SDGQVRMISCGADKSIYF 595
            S G++  ++ GA + ++F
Sbjct: 1135 SRGKLLQVNSGAREQLFF 1152



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 15/143 (10%)

Query: 93   ITALAFSPDGKY---LVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKY 148
            I  L  +   KY   + T + G  P++ +WD      ++ L+  H  GV  + FS + K 
Sbjct: 1417 ILCLTVNQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKL 1476

Query: 149  IVSVGYQHDMIVNVWAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLD 206
            +VSVG   +  + VW W++   VAS      R+  V F  D  + FV+ G +H+KFW L 
Sbjct: 1477 LVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLA 1536

Query: 207  DSKTSKVNATVPLLGRSGLLGEL 229
             S          LL + G++G L
Sbjct: 1537 GS---------ALLYKKGVIGSL 1550



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 74/277 (26%), Positives = 111/277 (40%), Gaps = 49/277 (17%)

Query: 469  DKADASLLDPRVGI----RSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEI 524
            D AD  LL+ +V +    R    SP+G+ +A G + G   +  + SL    K     S I
Sbjct: 1715 DLADKKLLN-KVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAI 1773

Query: 525  LCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQT--LDEHSSSITAVKFAASDGQV 582
              +  S PD   + LA  S +  +   D  +  +L +     +  S +  + F+A DG+ 
Sbjct: 1774 QDIRIS-PDN--RFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSA-DGKY 1829

Query: 583  RMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYT----AIGCQDR 638
              +S GA    Y R   +   G Q T    V+ K T        SW        IG   R
Sbjct: 1830 IQVSTGA----YKRQVHEVPLGKQVTEAV-VIEKITW------ASWTSVLGDEVIGIWPR 1878

Query: 639  NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVAT 698
            N    +++                         +G+ I T      + +FDF   E  A 
Sbjct: 1879 NADKADVNCAC-------------------VTHAGLNIVTGDDFGLVKLFDFPCTEKFAK 1919

Query: 699  ---MFGHSEIVTGMKFSNDCKHLISVSGDSC-IFVWR 731
                FGHS  VT ++FS D K+++S  GD C +FVWR
Sbjct: 1920 HKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1956



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 15/167 (8%)

Query: 505 VHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD 564
           V+  Q  S+ L +  HD +IL L    P           RD  IHV D      L     
Sbjct: 712 VYNRQQHSQRLYL-GHDDDILSLTIH-PVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKG 769

Query: 565 EHSSSITAVKFAASDGQVRMISCGAD--KSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDM 622
           +H   + A+ F+A DG+  ++S G D   SI F    K G+ +  TR H    K  ++ +
Sbjct: 770 QHQRGVCALDFSA-DGKC-LVSVGLDDFHSIVF-WDWKKGEKIATTRGH----KDKIFVV 822

Query: 623 DVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQT 669
              P      +    ++I+ +  + G     F   +G  G++ K++T
Sbjct: 823 KCNPHHVDKLVTVGIKHIKFWQQAGGG----FTSKRGTFGSVGKLET 865



 Score = 31.6 bits (70), Expect = 6.1
 Identities = 30/119 (25%), Positives = 50/119 (42%), Gaps = 6/119 (5%)

Query: 91   KTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSP-SAKYI 149
            K +  + FS  GK LV+        + VW   E ++VA    H   +  V F P S    
Sbjct: 1463 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQF 1522

Query: 150  VSVGYQH----DMIVNVWAWKKNIVVASNKVSSR-VTAVSFSEDCSYFVTAGNRHIKFW 203
            VSVG +H     +  +   +KK ++ +      + + +V+F  +   F  A N  +  W
Sbjct: 1523 VSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVW 1581


>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
           sapiens]
          Length = 620

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 55/179 (30%), Positives = 83/179 (46%), Gaps = 11/179 (6%)

Query: 37  SKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITAL 96
           +++ L+ V+G       GL C P    + YP GC V L      K+ + L      ++ L
Sbjct: 12  AELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTV-LIQAINTKEQNFLQGHGNNVSCL 70

Query: 97  AFSPDGKYLVTGE---SGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVG 153
           A S  G+Y+ +G+    G    + +WD      +A L  HK  +  +AFSP+  Y+VS+G
Sbjct: 71  AISRSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLG 130

Query: 154 YQHDMIVNVWAWKKNIVVASNKVS----SRVTAVSFSEDC--SYFVTAGNRHIKFWYLD 206
              D  V VW+  K   +  +  +       T V FS  C    F+TAGN  I+ W LD
Sbjct: 131 GPDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSR-CRDEMFMTAGNGTIRVWELD 188



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 37/173 (21%), Positives = 74/173 (42%), Gaps = 10/173 (5%)

Query: 559 LQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTT 618
           L++ L EH SS++ ++   ++ +    S      I+        D V+  R   ++  T 
Sbjct: 453 LEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIW--------DLVRLRRNQMILANTL 504

Query: 619 LYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIAT 678
              +   P          DR I  + +  G   +  +GS    G++  +     G++  T
Sbjct: 505 FQCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLS--GSINGMDITQEGVHFVT 562

Query: 679 SCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 731
             +D  + ++D++ GE      GHS  +T ++ S   ++++SVS D  I  W+
Sbjct: 563 GGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 52/201 (25%)

Query: 75  FNPRKHKQHHILNSSRKT-ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAE--LQ 131
           F P   +  +++N++ +  +TA+A + D K +++G  G    VRVW +   +Q  E  L+
Sbjct: 401 FAPETGRLMYVINNAHRIGVTAIATTSDCKRVISG--GGEGEVRVWQIGCQTQKLEEALK 458

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIV-NVWAWKKNIVVASN---------------- 174
           EHK  V+C+    + +  V+       I+ ++   ++N ++ +N                
Sbjct: 459 EHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCVCYHPEEFQII 518

Query: 175 ------------------------KVSSRVTAVSFSEDCSYFVTAGNRH-IKFWYLDDSK 209
                                    +S  +  +  +++  +FVT GN H +K W  ++ +
Sbjct: 519 TSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGE 578

Query: 210 TSKVNATVPLLGRSGLLGELR 230
            + V      +G SG +  +R
Sbjct: 579 VTHVG-----VGHSGNITRIR 594


>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
           sapiens]
          Length = 1977

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 64/222 (28%), Positives = 99/222 (44%), Gaps = 19/222 (8%)

Query: 49  VSGGRGLACDP-----RSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
           V G RG  C       + G + Y    V V++N +++ Q   L      I  L   P   
Sbjct: 682 VHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHD-DDILCLTIHPLKD 740

Query: 104 YLVTGESGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNV 162
           Y+ TG+ G  P++ +WD      ++ L+  H+YGV+ V FS   K + SVG      V +
Sbjct: 741 YVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVL 800

Query: 163 WAWKKNIVVASNKVS-SRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLL 220
           W WKK   ++  + S  ++  V  +       +TAG +H+KFW           A   L+
Sbjct: 801 WDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWR---------KAGGGLI 851

Query: 221 GRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSD 262
           GR G +G L  N  T +    G   +  F  TS+G +C + D
Sbjct: 852 GRKGYIGTLGKN-DTMMCAVYGWTEEMAFSGTSTGDVCIWRD 892



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 87/341 (25%), Positives = 144/341 (42%), Gaps = 49/341 (14%)

Query: 64  VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAE 123
           + Y    V V+++PR+H+Q      S   I +LA  P+   + TG+ G  P + +WD   
Sbjct: 36  IVYFVAGVGVVYSPREHRQKFYRGHS-DDIISLALHPERVLVATGQVGKEPYICIWDSYT 94

Query: 124 HSQVAELQE-HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVA-SNKVSSRVT 181
              ++ L++ H +G+AC+AF    + +VSVG      V VW WK+  +++ +   + R+ 
Sbjct: 95  VQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIF 154

Query: 182 AVSFS-EDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG 240
            +S+     +  V+ G +HIKFW L        NA  P  G  G  G+L+  L   +AC 
Sbjct: 155 DISWDLYQPNKLVSCGVKHIKFWSLCG------NALTPKRGVFGKTGDLQTILC--LACA 206

Query: 241 RGKKADSTFCITSSGLLCEFSDRRLLDKWVEL-RNIDSFTTTVAHCISVSQDYIFCGCAD 299
           R +       +T SG L   +    + K + L R I          ++  ++    G  D
Sbjct: 207 RDE-------LTYSGAL---NGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRD 256

Query: 300 GTVRL----FNPSNLHFLSTLPRPHALGTDIASV----------TEASRLFSGVANARYP 345
           G +RL    F P  +  L    + +  G  + SV          T+ S +F  V   R  
Sbjct: 257 GCIRLWDLTFKPITVIDLRETDQGYK-GLSVRSVCWRGDHILVGTQDSEIFEIVVQERNK 315

Query: 346 DTI-----------ALTFDPTNQWLSCVYNDHSIYVWDVRD 375
             +           AL   PT        +D S+ +W + D
Sbjct: 316 PFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVD 356



 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 101/479 (21%), Positives = 184/479 (38%), Gaps = 82/479 (17%)

Query: 110  SGHMPAVRVWDVAEHSQVAELQ-EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKN 168
            S   P++ +WD      ++ L+  H  GV  V+FS + K ++SVG   +  + +W W++ 
Sbjct: 1452 SATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEG 1511

Query: 169  IVVASNK-VSSRVTAVSFSEDC-SYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLL 226
              +AS    + R+    F  D  + FV+ G +H+KFW L         A   LL + GLL
Sbjct: 1512 AKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL---------AGRALLSKKGLL 1562

Query: 227  GELRN-NLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRN--IDSFTTTVA 283
              L +  + T +A   G   + TF  T SG +C + D  L        N  + +  TT+ 
Sbjct: 1563 STLEDARMQTMLAIAFGAN-NLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLR 1621

Query: 284  HCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASR--------L 335
              + V+          G V+L++         L R  A   +    T+  R        +
Sbjct: 1622 DGLIVTGGKERPSKEGGAVKLWD-------QELRRCRAFRLETGQATDCVRSVCRGKGKI 1674

Query: 336  FSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSV 395
              G  NA       +     N   + + N H      V  P               +W +
Sbjct: 1675 LVGTRNAE-----IIEVGEKNAACNILVNGH------VDGP---------------IWGL 1708

Query: 396  EVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGV-------HGSTLHRNILSSDLI 448
              +P              F++ + D T+RLW+     +       H +         D++
Sbjct: 1709 ATHPS----------RDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMV 1758

Query: 449  KIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL 508
             I   +G    LL + L    K      D R  I  +  SP+ ++LA G    ++  ++L
Sbjct: 1759 AIGMKNGEFIILLVSSL----KIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDL 1814

Query: 509  ---QSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD 564
                +L+ +   +   S ++ +++S  D+    ++S    R ++ + +G+       +D
Sbjct: 1815 TLGPTLNRISYCKDIPSFVIQMDFS-ADSSYLQVSSGCYKRHVYEVPSGKHLMDHAAID 1872



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 76/346 (21%), Positives = 138/346 (39%), Gaps = 59/346 (17%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           IR   V+ +G HLA G + G+  V  ++ ++E++ ++     I  L+YS   T    LA 
Sbjct: 369 IRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGT---YLAV 425

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRT-AQK 600
              D  + +    + Y          S IT + ++ SD +    + G  K +++R    K
Sbjct: 426 GCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWS-SDSRYLQTNDGNGKRLFYRMPGGK 484

Query: 601 SGDGVQFTRTHHVVRKTTLYDMDVEPSW-KYTAIGCQDRNIRIFNISSGKQKKLFKGSQG 659
                +  +  H    T +  ++V   W KY+ I          +I+S            
Sbjct: 485 EVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDIN---------DINS------------ 523

Query: 660 EDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS---SGECVATMFGHSEIVTGMKFSNDCK 716
            DG  I       G  + T+     + +F +     G       GHS  VT +++S+D +
Sbjct: 524 VDGNYI-------GQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQ 576

Query: 717 HLISVSG-DSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRA-SGPNRHQAP 774
            +IS+ G D  +F W+   E  +     +A                PQ + +  +  ++ 
Sbjct: 577 WVISIGGADHSVFQWKFIPERKLKDAVHIA----------------PQESLADSHSDESD 620

Query: 775 SMLSPGPALSSDSDKEGE----DEGTEEELPALPVLAKSTKKALAS 816
           S LS  P L S+ ++E +     +  +E+LP L    K  +K+  S
Sbjct: 621 SDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATS 666



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%)

Query: 672  SGIYIATSCSDKNLSIFDFSSGECVAT---MFGHSEIVTGMKFSNDCKHLISVSGDSC-I 727
            SGI + T      + +FDF   E  A      GHS  VT ++F++  +H++S  GD C +
Sbjct: 1908 SGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSL 1967

Query: 728  FVWR 731
            FVW+
Sbjct: 1968 FVWK 1971



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)

Query: 520 HDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASD 579
           HD +ILCL    P           RD  IH+ D      L      H   ++AV F+A D
Sbjct: 726 HDDDILCLTIH-PLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSA-D 783

Query: 580 GQVRMISCGADKS 592
           G+ R+ S G D S
Sbjct: 784 GK-RLASVGIDDS 795



 Score = 32.0 bits (71), Expect = 4.7
 Identities = 37/149 (24%), Positives = 57/149 (38%), Gaps = 16/149 (10%)

Query: 590  DKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEP-SWKYTAIGCQDRNIRIFNISSG 648
            D S     A    D V F   HH  RK  + D+   P S KY A+   D  I I+N+ S 
Sbjct: 1061 DGSFLMANADTLEDLVSF---HH--RKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSS 1115

Query: 649  KQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTG 708
            K+  + KG+      +  +  D  G  +  +   K    F+   G+         E +  
Sbjct: 1116 KRVGICKGA---TSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAW 1172

Query: 709  MKFSNDCKHLISVSGDSCIFVWRLSSEMT 737
              ++       SV G  C  +W +  E+T
Sbjct: 1173 ASWT-------SVLGLCCEGIWPVIGEVT 1194


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 69/256 (26%), Positives = 117/256 (45%), Gaps = 26/256 (10%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           + SV  SP+G  LAS  R  T+R+       +  + +AH + +  +++S      + LA+
Sbjct: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG---QFLAT 119

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSI-YFRTAQK 600
           AS D+ I V    R+  L  +L  H+  +   KF+  DG++ ++SC  DK+I  + T  K
Sbjct: 120 ASEDKSIKVWSMYRQRFLY-SLYRHTHWVRCAKFSP-DGRL-IVSCSEDKTIKIWDTTNK 176

Query: 601 S-----GDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFK 655
                  D V F              +D  PS    A    D+ ++++++   +  KL +
Sbjct: 177 QCVNNFSDSVGFANF-----------VDFNPSGTCIASAGSDQTVKVWDV---RVNKLLQ 222

Query: 656 GSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDC 715
             Q   G +  +   PSG Y+ T+ SD  L I D   G  + T+ GH+  V  + FS   
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282

Query: 716 KHLISVSGDSCIFVWR 731
           +   S   D+ + +WR
Sbjct: 283 ELFASGGADTQVLLWR 298



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 34/116 (29%), Positives = 51/116 (43%), Gaps = 6/116 (5%)

Query: 90  RKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYI 149
           +  IT+L  SP+GK L T        + +W+   H++      HK  V  V FSP    +
Sbjct: 18  KAAITSLDLSPNGKQLATASWDTF--LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75

Query: 150 VSVGYQHDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
            S     D  V +W   K    +  K  ++ V +V FS D  +  TA  ++ IK W
Sbjct: 76  ASA--SRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 32/134 (23%), Positives = 56/134 (41%), Gaps = 6/134 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           V L+ P K  +     +    + ++ FS DG++L T       +++VW +     +  L 
Sbjct: 84  VRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK--SIKVWSMYRQRFLYSLY 141

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVW-AWKKNIVVASNKVSSRVTAVSFSEDCS 190
            H + V C  FSP  + IVS     D  + +W    K  V   +        V F+   +
Sbjct: 142 RHTHWVRCAKFSPDGRLIVSC--SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGT 199

Query: 191 YFVTAG-NRHIKFW 203
              +AG ++ +K W
Sbjct: 200 CIASAGSDQTVKVW 213



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 45/209 (21%), Positives = 80/209 (38%), Gaps = 36/209 (17%)

Query: 349 ALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQAC 408
           ++ F    Q+L+    D SI VW +   + +   YS   H+  V   +  P+ +      
Sbjct: 107 SVDFSADGQFLATASEDKSIKVWSMYRQRFL---YSLYRHTHWVRCAKFSPDGR------ 157

Query: 409 LPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGG 468
                 ++CS D TI++W+T +          N  S  +    +VD N           G
Sbjct: 158 ----LIVSCSEDKTIKIWDTTNKQCV------NNFSDSVGFANFVDFNPSGTCIAS--AG 205

Query: 469 DKADASLLDPRV------------GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLK 516
                 + D RV            G+  +   P+G +L +    GTL++ +L     +  
Sbjct: 206 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265

Query: 517 VEAHDSEILCLEYSKPDTGLKLLASASRD 545
           ++ H   +  + +SK   G +L AS   D
Sbjct: 266 LQGHTGPVFTVSFSK---GGELFASGGAD 291



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 6/134 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           ++L+N + H + +     +  +T++ FSP G  L +        VR+W   +  + +E +
Sbjct: 42  LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDR--TVRLWIPDKRGKFSEFK 99

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWA-WKKNIVVASNKVSSRVTAVSFSEDCS 190
            H   V  V FS   +++ +     D  + VW+ +++  + +  + +  V    FS D  
Sbjct: 100 AHTAPVRSVDFSADGQFLATA--SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157

Query: 191 YFVTAG-NRHIKFW 203
             V+   ++ IK W
Sbjct: 158 LIVSCSEDKTIKIW 171



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 27/128 (21%), Positives = 58/128 (45%), Gaps = 3/128 (2%)

Query: 612 HVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDP 671
           +V  K  +  +   P     A   +DR +R++ I   + K  F   +     +  V    
Sbjct: 56  YVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGK--FSEFKAHTAPVRSVDFSA 112

Query: 672 SGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 731
            G ++AT+  DK++ ++       + +++ H+  V   KFS D + ++S S D  I +W 
Sbjct: 113 DGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD 172

Query: 732 LSSEMTIS 739
            +++  ++
Sbjct: 173 TTNKQCVN 180



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 3/99 (3%)

Query: 98  FSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHD 157
           F+P G  + +  +G    V+VWDV  +  +   Q H  GV C++F PS  Y+++      
Sbjct: 194 FNPSGTCIAS--AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251

Query: 158 MIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAG 196
           + + +   +  ++      +  V  VSFS+    F + G
Sbjct: 252 LKI-LDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 19/73 (26%), Positives = 34/73 (46%)

Query: 658 QGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKH 717
           +G    +  +   P+G  +AT+  D  L +++F          GH ++VT ++FS     
Sbjct: 15  KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74

Query: 718 LISVSGDSCIFVW 730
           L S S D  + +W
Sbjct: 75  LASASRDRTVRLW 87



 Score = 34.7 bits (78), Expect = 0.72
 Identities = 23/87 (26%), Positives = 41/87 (47%), Gaps = 8/87 (9%)

Query: 82  QHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVA 141
           QH+ ++S    +  ++F P G YL+T  S     +++ D+ E   +  LQ H   V  V+
Sbjct: 222 QHYQVHSGG--VNCISFHPSGNYLITASSD--GTLKILDLLEGRLIYTLQGHTGPVFTVS 277

Query: 142 FSPSAKYIVSVGYQHDMIVNVWAWKKN 168
           FS   +   S G    +++    W+ N
Sbjct: 278 FSKGGELFASGGADTQVLL----WRTN 300


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 86/329 (26%), Positives = 149/329 (45%), Gaps = 27/329 (8%)

Query: 412 SSFITCSSDNTIRLWNTESSGVHGSTL--HRNILSSDLIKIIYVDGNTQALLDTELPGGD 469
           S FIT S D T +LW+T +SG   +TL  HRN++ +      Y D       D       
Sbjct: 105 SCFITGSYDRTCKLWDT-ASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163

Query: 470 KADASLLDPRVGIRS--VCVSPNGQH--LASGDRMGTLRVHELQSLSEMLKVEAHDSEIL 525
                      G  +  VC+S N Q   +A+G    T ++ ++Q+  E+  +  H +EI+
Sbjct: 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223

Query: 526 CLEYSKPDTGLKLLASASRDRLIHVLDA--GREYSLQQTLDEHSSSITAVKFAASDGQVR 583
            L ++   T    + + S D  + V DA  GR+ ++   L  H + I++  F   +    
Sbjct: 224 SLSFN---TSGDRIITGSFDHTVVVWDADTGRKVNI---LIGHCAEISSASF---NWDCS 274

Query: 584 MISCGA-DKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRI 642
           +I  G+ DK+     A  +G  V  T T H      + D   + + K  A    D   RI
Sbjct: 275 LILTGSMDKTCKLWDAT-NGKCVA-TLTGH---DDEILDSCFDYTGKLIATASADGTARI 329

Query: 643 FNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGH 702
           F+ ++   +K     +G +G + K+  +P G ++ T  SDK   I+D  +G+C+  + GH
Sbjct: 330 FSAAT---RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH 386

Query: 703 SEIVTGMKFSNDCKHLISVSGDSCIFVWR 731
           ++ +    F+     +I+ S D+   +WR
Sbjct: 387 TDEIFSCAFNYKGNIVITGSKDNTCRIWR 415



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 35/149 (23%), Positives = 67/149 (44%), Gaps = 15/149 (10%)

Query: 74  LFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEH 133
           L++    K +H        I  L+F+P    + TG        ++WD+    +V  L+ H
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD--TTAKLWDIQNGEEVYTLRGH 218

Query: 134 KYGVACVAFSPSAKYIVSVGYQHDMIVNVW----AWKKNIVVASNKVSSRVTAVSFSEDC 189
              +  ++F+ S   I++  + H ++  VW      K NI++      + +++ SF+ DC
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVV--VWDADTGRKVNILIGH---CAEISSASFNWDC 273

Query: 190 SYFVTAG-NRHIKFWYLDDSKTSKVNATV 217
           S  +T   ++  K W   D+   K  AT+
Sbjct: 274 SLILTGSMDKTCKLW---DATNGKCVATL 299



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 47/258 (18%), Positives = 106/258 (41%), Gaps = 13/258 (5%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           + +V ++ +G    +G    T ++ +  S  E+  +E H + +  + ++ P        S
Sbjct: 95  LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKS 601
             +   +  ++ G+ Y    T   H++ I  + F   + Q  +++ G+  +       ++
Sbjct: 155 FDKTCKLWSVETGKCY---HTFRGHTAEIVCLSF---NPQSTLVATGSMDTTAKLWDIQN 208

Query: 602 GDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGED 661
           G+ V   R H       +  +    S      G  D  + +++  +G++  +  G   E 
Sbjct: 209 GEEVYTLRGH----SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEI 264

Query: 662 GTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISV 721
            +      D S   I T   DK   ++D ++G+CVAT+ GH + +    F    K + + 
Sbjct: 265 SSA-SFNWDCS--LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321

Query: 722 SGDSCIFVWRLSSEMTIS 739
           S D    ++  ++   I+
Sbjct: 322 SADGTARIFSAATRKCIA 339



 Score = 37.7 bits (86), Expect = 0.085
 Identities = 47/200 (23%), Positives = 75/200 (37%), Gaps = 39/200 (19%)

Query: 346 DTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKV-------GKVYSALYHSSCVWSVEVY 398
           + I+L+F+ +   +     DH++ VWD    +KV        ++ SA ++  C       
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC------- 273

Query: 399 PEVKDSNQACLPPSSFITCSSDNTIRLWN-TESSGVHGSTLHRN-ILSS------DLIKI 450
                        S  +T S D T +LW+ T    V   T H + IL S       LI  
Sbjct: 274 -------------SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320

Query: 451 IYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQS 510
              DG  +           K  A L      I  +  +P G HL +G    T R+ + Q+
Sbjct: 321 ASADGTARIF----SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376

Query: 511 LSEMLKVEAHDSEILCLEYS 530
              +  +E H  EI    ++
Sbjct: 377 GQCLQVLEGHTDEIFSCAFN 396



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 46/234 (19%), Positives = 94/234 (40%), Gaps = 21/234 (8%)

Query: 346 DTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSN 405
           + + L+F+P +  ++    D +  +WD+++ +   +VY+   HS+ + S+          
Sbjct: 179 EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE---EVYTLRGHSAEIISLSFNTS----- 230

Query: 406 QACLPPSSFITCSSDNTIRLWNTESSG----VHGSTLHRNILSSDLIKIIYVDGNTQALL 461
                    IT S D+T+ +W+ ++      + G     +  S +    + + G+     
Sbjct: 231 -----GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285

Query: 462 DTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHD 521
                   K  A+L      I   C    G+ +A+    GT R+    +   + K+E H+
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHE 345

Query: 522 SEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF 575
            EI  + ++        L + S D+   + DA     L Q L+ H+  I +  F
Sbjct: 346 GEISKISFNPQGNH---LLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSCAF 395



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 19/61 (31%), Positives = 30/61 (49%)

Query: 653 LFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFS 712
           LFK  +     L  V  + SG    T   D+   ++D +SGE + T+ GH  +V  + F+
Sbjct: 84  LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 713 N 713
           N
Sbjct: 144 N 144



 Score = 31.2 bits (69), Expect = 8.0
 Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 2/59 (3%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVS 151
           I+ ++F+P G +L+TG S      R+WD      +  L+ H   +   AF+     +++
Sbjct: 348 ISKISFNPQGNHLLTGSSD--KTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVIT 404


>gi|56790932 echinoderm microtubule associated protein like 1
           isoform a [Homo sapiens]
          Length = 834

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 180/761 (23%), Positives = 269/761 (35%), Gaps = 173/761 (22%)

Query: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLE-KVLGIT-VSGGRGLACDPRSGLVAYPAG 69
           +K  LR   + +   K       L +KV L  K L +  V G RG  C  R+ L   P G
Sbjct: 206 VKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDC--RNNLYLLPTG 263

Query: 70  -------CVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------P 114
                   VVVL+N  +  Q H    +   +  LA  PD   + TG+            P
Sbjct: 264 ETVYFIASVVVLYNVEEQLQRHYAGHN-DDVKCLAVHPDRITIATGQVAGTSKDGKQLPP 322

Query: 115 AVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVSVGYQHDMIVNVWAWKKNIV 170
            VR+WD    +   V  +      V C+AFS S     + +V   +D +++VW W+K   
Sbjct: 323 HVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEK 382

Query: 171 VASNKVSSR-VTAVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGE 228
           +A  K S+  V A  F   D +  VT G  H+ FW L+ S  +K         + GL  +
Sbjct: 383 LADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNK---------KQGLFEK 433

Query: 229 LRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISV 288
                F  V C    +   T    SSG +           W +  N  S+    AH   +
Sbjct: 434 QEKPKF--VLCVTFSENGDTITGDSSGNIL---------VWGKGTNRISYAVQGAHEGGI 482

Query: 289 SQDYIFCGCADGTV--------RLFNPS-NLHFLSTLPRPHALGTDIASVTEASR---LF 336
              +  C   DGT+        +L + S N   L     P   G  I +V E      L 
Sbjct: 483 ---FALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFG-PIRTVAEGKGDVILI 538

Query: 337 SGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE 396
               N     T++  F P  Q                              H+  +W + 
Sbjct: 539 GTTRNFVLQGTLSGDFTPITQG-----------------------------HTDELWGLA 569

Query: 397 VYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGN 456
           ++             S F+TC  D    LW+           HR +      KII     
Sbjct: 570 IHAS----------KSQFLTCGHDKHATLWDAVG--------HRPVWD----KII----- 602

Query: 457 TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLK 516
                       D A +S   P           +G  +A G   G   V + ++  +++ 
Sbjct: 603 -----------EDPAQSSGFHP-----------SGSVVAVGTLTGRWFVFDTET-KDLVT 639

Query: 517 VEAHDSEILCLEYSKPDTGLKLLASASRDRLIH---VLDAGREYSLQQTLDEHSSSITAV 573
           V    +E L +    PD     LA  S D  I+   V D GR+Y+       HSS IT +
Sbjct: 640 VHTDGNEQLSVMRYSPDG--NFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHL 697

Query: 574 KFAASDGQVRMISCGADKSIYF-RTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTA 632
            ++  + Q  + + G  + +Y+  +A K    V+ TR       T      V   W   +
Sbjct: 698 DWSV-NSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGS 756

Query: 633 IGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSS 692
            G       I  +    +KKL   S G+D   + + + P   + A S       I+    
Sbjct: 757 DGTD-----INAVCRAHEKKLL--STGDDFGKVHLFSYPCSQFRAPS------HIYG--- 800

Query: 693 GECVATMFGHSEIVTGMKFSNDCKHLISVSG-DSCIFVWRL 732
                   GHS  VT + F  +  HLIS  G D+ I  WR+
Sbjct: 801 --------GHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRV 833


>gi|56790930 echinoderm microtubule associated protein like 1
           isoform b [Homo sapiens]
          Length = 815

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 180/761 (23%), Positives = 269/761 (35%), Gaps = 173/761 (22%)

Query: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLE-KVLGIT-VSGGRGLACDPRSGLVAYPAG 69
           +K  LR   + +   K       L +KV L  K L +  V G RG  C  R+ L   P G
Sbjct: 187 VKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDC--RNNLYLLPTG 244

Query: 70  -------CVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------P 114
                   VVVL+N  +  Q H    +   +  LA  PD   + TG+            P
Sbjct: 245 ETVYFIASVVVLYNVEEQLQRHYAGHN-DDVKCLAVHPDRITIATGQVAGTSKDGKQLPP 303

Query: 115 AVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVSVGYQHDMIVNVWAWKKNIV 170
            VR+WD    +   V  +      V C+AFS S     + +V   +D +++VW W+K   
Sbjct: 304 HVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEK 363

Query: 171 VASNKVSSR-VTAVSFSE-DCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGE 228
           +A  K S+  V A  F   D +  VT G  H+ FW L+ S  +K         + GL  +
Sbjct: 364 LADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNK---------KQGLFEK 414

Query: 229 LRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISV 288
                F  V C    +   T    SSG +           W +  N  S+    AH   +
Sbjct: 415 QEKPKF--VLCVTFSENGDTITGDSSGNIL---------VWGKGTNRISYAVQGAHEGGI 463

Query: 289 SQDYIFCGCADGTV--------RLFNPS-NLHFLSTLPRPHALGTDIASVTEASR---LF 336
              +  C   DGT+        +L + S N   L     P   G  I +V E      L 
Sbjct: 464 ---FALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFG-PIRTVAEGKGDVILI 519

Query: 337 SGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE 396
               N     T++  F P  Q                              H+  +W + 
Sbjct: 520 GTTRNFVLQGTLSGDFTPITQG-----------------------------HTDELWGLA 550

Query: 397 VYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGN 456
           ++             S F+TC  D    LW+           HR +      KII     
Sbjct: 551 IHAS----------KSQFLTCGHDKHATLWDAVG--------HRPVWD----KII----- 583

Query: 457 TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLK 516
                       D A +S   P           +G  +A G   G   V + ++  +++ 
Sbjct: 584 -----------EDPAQSSGFHP-----------SGSVVAVGTLTGRWFVFDTET-KDLVT 620

Query: 517 VEAHDSEILCLEYSKPDTGLKLLASASRDRLIH---VLDAGREYSLQQTLDEHSSSITAV 573
           V    +E L +    PD     LA  S D  I+   V D GR+Y+       HSS IT +
Sbjct: 621 VHTDGNEQLSVMRYSPDG--NFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHL 678

Query: 574 KFAASDGQVRMISCGADKSIYF-RTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTA 632
            ++  + Q  + + G  + +Y+  +A K    V+ TR       T      V   W   +
Sbjct: 679 DWSV-NSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGS 737

Query: 633 IGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSS 692
            G       I  +    +KKL   S G+D   + + + P   + A S       I+    
Sbjct: 738 DGTD-----INAVCRAHEKKLL--STGDDFGKVHLFSYPCSQFRAPS------HIYG--- 781

Query: 693 GECVATMFGHSEIVTGMKFSNDCKHLISVSG-DSCIFVWRL 732
                   GHS  VT + F  +  HLIS  G D+ I  WR+
Sbjct: 782 --------GHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRV 814


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 171/711 (24%), Positives = 239/711 (33%), Gaps = 138/711 (19%)

Query: 758  GP-SSPQRASGPNRHQAPSMLSPGPALSSD---SDKEGEDEGTEEELPALPVLAKSTKKA 813
            GP SSP RASG  R        PGP        S +E    G   E P    L+   ++ 
Sbjct: 112  GPVSSPGRASGTTR--------PGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRD 163

Query: 814  LASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRG--RWVQPGVELSVRSMLD 871
              S P+P  P          A   VG   PAP+A P P   G  + V    E S      
Sbjct: 164  -TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSP 222

Query: 872  -LRQLETLAPSLQDPSQDSL---AIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSY 927
              R+  +    LQ P+  SL   A   S P + G  A  T     +   P+P+  Q    
Sbjct: 223  AARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP 282

Query: 928  PHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARGTLGRVYPGS 987
            P +                  P +D      P+  P + +S     +P+ GT  R  P  
Sbjct: 283  PQV----------------TPPRKDA----APALGP-LSSSPLATPSPS-GTKARPVP-- 318

Query: 988  RSSEKHSPDSACSVDYSSSCLSSP---EHPTEDSESTEPLSVDGISSDLEEPAEGDEEEE 1044
                   PD+A +   ++   S P     P      + P S+  + S    P        
Sbjct: 319  ------PPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSM 372

Query: 1045 EEEGGMGPYGLQEGSP-QTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLL 1103
                   P  LQ   P Q P        H  T  S  AP +P+ +     + S+ S  L 
Sbjct: 373  TTPPMQAPPSLQTIPPIQVP--------HSLTSPSLQAPPSPLALSSLQATTSLGSPTLQ 424

Query: 1104 QVQTRPLREPSPSSSSLALMSRPAQVPQASG--EQPRGNGANPP---GAPPEVEP----- 1153
               +     P  + +SL   SRPA  P  S   + P    A+PP      P V P     
Sbjct: 425  ATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPL 484

Query: 1154 ---------SSGNPSPQ-QAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLV 1203
                     S  + SPQ   +S+++P   L   SS AP  + T          +++ SL 
Sbjct: 485  TIHPLQALSSLASHSPQAPLSSLIMP--PLETQSSLAPPSLQTPPASLTTPPLENLPSLA 542

Query: 1204 PQERHEAS------------------LQAP----------SPGALLSREIEAQDGLGSLP 1235
            P     AS                  LQAP          +P ++ +   +A   L S P
Sbjct: 543  PPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS-P 601

Query: 1236 PADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLALPS--- 1292
            P  G PS P S   P  +   +    +++     L A P   +P    PLS LA PS   
Sbjct: 602  PLQGLPSPPLS---PLATPPPQAPPXLALPP---LQAPP---SPPASPPLSPLATPSPQA 652

Query: 1293 ----RAHLVLDIPKPLPDRPTLAAFS-----PVTKGRAPGEAEKPGFPVGLGKAHSTTER 1343
                  HL+     P P  P  A FS     PV+    P     P       +   +   
Sbjct: 653  PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA 712

Query: 1344 WACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKTP 1394
               +    TP P+      P P +    Q+P S     P +    PP + P
Sbjct: 713  SPPMSPSATPPPQA-----PPPLAAPPLQVPPSPPASPPMSPSATPPPRVP 758



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 168/738 (22%), Positives = 239/738 (32%), Gaps = 123/738 (16%)

Query: 762  PQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPA 821
            P    G  R  + S+ S    LSS +       GT    PA P   K         P   
Sbjct: 228  PSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRA-PAHPSQPKPKGLQALRPPQVT 286

Query: 822  LPRSLSHWEMSRAQESVGFLDPAPAANPGPR-RRGRWVQPGVELSVRSMLDLRQLETLAP 880
             PR         A  ++G L  +P A P P   + R V P    +      L     LA 
Sbjct: 287  PPRK-------DAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLAT 339

Query: 881  SLQ----DPSQD-SLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLS 935
             L      PS   SL  +PS P     +A  +  T   + PP  Q   P   PH +   S
Sbjct: 340  PLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPS 399

Query: 936  QEEGVFAQDLEPAPIEDGIVYPEPS-DNPTMD-TSEFQVQAPARGTLGRVYPGSRSSEKH 993
             +         P+P+    +    S  +PT+  T  F   +P +       P   +S   
Sbjct: 400  LQA-------PPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPP 452

Query: 994  -------------SPDSACSVDYSSSCLSSPE--HPTEDSESTEPLSVDGISSDLEEPAE 1038
                         SP    S+  + S LSSP   HP +   S    S     S L  P  
Sbjct: 453  DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPL 512

Query: 1039 GDEEEEEEEGGMGPYGLQE--GSPQTPDQEQF---------------LKQHFETLASGA- 1080
                  E +  + P  LQ    S  TP  E                    H ET    A 
Sbjct: 513  ------ETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP 566

Query: 1081 ----APGAPVQVPERSESRSISS---RFLLQVQTRPLRE-PSPSSSSLALMSRPAQVPQA 1132
                AP +P+  P      SI++   +    + + PL+  PSP  S LA  + P Q P  
Sbjct: 567  CPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLA--TPPPQAPPX 624

Query: 1133 SGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSG 1192
                P     +PP +PP    ++ +P    A +V L +   +P     P      +PFS 
Sbjct: 625  LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP-----PPSPPVQAPFSP 679

Query: 1193 LQKAQSVHSLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTT 1252
                    S  P  +   SL AP         ++      + PP     + P     P  
Sbjct: 680  PASPPVSPSATPPSQAPPSLAAP--------PLQVPPSPPASPPMSPSATPPPQAPPPLA 731

Query: 1253 SSMAKISRSISVGENLGLVAEPQAHAP--IRVSPLSKLALPSRAHLVLDIPKPLPDRPTL 1310
            +   ++  S      +   A P    P  +   PL     P  +  +  + KP P  P  
Sbjct: 732  APPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPA 791

Query: 1311 AAFSPVTKGRAPGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTE-------CQAHP 1363
             A  P+    +P       FP   G+A  +      +    TP P+          Q  P
Sbjct: 792  LATPPLQALPSP----PASFP---GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP 844

Query: 1364 GPSSPCAQQLPVSSLFQGPENL-------------QPPPPEKTPNPMECTKPGAALSQDS 1410
             P +    Q P      GP+                PPPP ++P+    T  G  L+  S
Sbjct: 845  SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS---STLSGPDLAGHS 901

Query: 1411 EPAVSLEQCEQLVAELRG 1428
              A S  +      ELRG
Sbjct: 902  SSATSTPE------ELRG 913



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 188/835 (22%), Positives = 274/835 (32%), Gaps = 129/835 (15%)

Query: 753  GGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVL-AKSTK 811
            G K +    P  A+ P     P+ L P P L++              L  LP   A    
Sbjct: 311  GTKARPVPPPDNAATP----LPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPS 366

Query: 812  KALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLD 871
            +A  S+ +P +    S   +   Q       P+  A P P      +Q    L   ++  
Sbjct: 367  QAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSS-LQATTSLGSPTLQA 425

Query: 872  LRQLETLAP-----SLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCS 926
                 T++P     SL  PS+ + +  P  P      +L  S   Q    P   A  P S
Sbjct: 426  THSFLTMSPRQTQASLTSPSRPA-STPPDSPPLQAPLSLPASPPLQTSLSP---AVSPLS 481

Query: 927  YPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDN----PTMDTSEFQVQAPARGTLGR 982
             P  I  L Q     A     AP+   I+ P  + +    P++ T    +  P    L  
Sbjct: 482  SPLTIHPL-QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPS 540

Query: 983  VYPG---SRSSEKHSPD-------SACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSD 1032
            + P    + S+   +P        + C +    S L++P   T  S +T P       + 
Sbjct: 541  LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALAS 600

Query: 1033 LEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERS 1092
               P +G          + P  L    PQ P                + P +P+  P   
Sbjct: 601  --PPLQGLPSPP-----LSP--LATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQ 651

Query: 1093 ESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVE 1152
               +++   LLQ        P PS    A  S PA  P +    P         APP   
Sbjct: 652  APNALAVH-LLQAPF----SPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 706

Query: 1153 PSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFS-GLQKAQSVHSLVPQERHEAS 1211
            P S   SP  + S   P  +  P  +  P +V  + P S  +  + +    VP       
Sbjct: 707  PPSPPASPPMSPSA-TPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPP 765

Query: 1212 LQA-PSPGA------LLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISV 1264
            LQ  PSP A      L     +A   L + PP    PS P S+        A  S S S+
Sbjct: 766  LQVPPSPPASLPMSPLAKPPPQAPPALAT-PPLQALPSPPASF-----PGQAPFSPSASL 819

Query: 1265 GENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPK--PLPDRPTLAAFSPVTKGRAP 1322
              +      PQA  P+  +PL ++     A   L  P+  P P   T  +   +T   AP
Sbjct: 820  PMSPLATPPPQA-PPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP 878

Query: 1323 GEAEKP--------GFPVGLGKAHSTTERWACL---------GEGTTPKPRTECQA-HP- 1363
            G    P          P   G + S T     L         G   +P P  E  A HP 
Sbjct: 879  GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA 938

Query: 1364 ----GPSSPCA-QQLPVSSL-------------------FQGPENLQPPPPEKTPNPMEC 1399
                GP+ P A +  P + L                    +GPE+  P P    P P   
Sbjct: 939  AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 998

Query: 1400 TKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRIAQLLRD 1459
            T  G A +     A S    +  + EL     QA  + H ++   + +A           
Sbjct: 999  TSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAA----------- 1047

Query: 1460 TFSSVRQELEAVAGAVLSSPGSS-----PGAVGAEQTQALLEQYSELLLRAVERR 1509
                     E  AG     PG +      G   A  + A L +++ELL    E R
Sbjct: 1048 --------AEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESR 1094



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 73/325 (22%), Positives = 107/325 (32%), Gaps = 54/325 (16%)

Query: 1115 PSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEP--SSGNPSP----QQAASVLL 1168
            P+ S+      PA  P ASG   R   A      P   P  +SG   P    Q+   +  
Sbjct: 79   PTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 138

Query: 1169 PRCRLNPDSSWAPKRVA--------TASPFSGL--------QKAQSVHSLVPQERHEASL 1212
                    ++ APKR A        T+ P  G          +A      +P+    A  
Sbjct: 139  EETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP 198

Query: 1213 QAPSPGALLSREIEAQDGLGS-LPPADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLV 1271
            + P+ G   S    ++       P A  RPS     Q P + S++  +  +S        
Sbjct: 199  RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS-------- 250

Query: 1272 AEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPD-RPTLAAFSPVTKGRAPGEAEKPGF 1330
                  +P R  P ++    + AH     PK L   RP     +P  K  AP        
Sbjct: 251  ------SPARSGPSARGTPRAPAHPSQPKPKGLQALRP--PQVTPPRKDAAPALGPLSSS 302

Query: 1331 PVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPP 1390
            P+       T  R         P P  +  A P P++     LP S     P  L PP P
Sbjct: 303  PLATPSPSGTKAR---------PVPPPDNAATPLPAT-----LPPSPPLATPLPLAPPSP 348

Query: 1391 EKTPNPMECTKPGAALSQDSEPAVS 1415
               P+      P A     + P+++
Sbjct: 349  SAPPSLQTLPSPPATPPSQAPPSMT 373


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 61/250 (24%), Positives = 107/250 (42%), Gaps = 14/250 (5%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           +  V  SP+G  LASG R  T+R+       E     AH + +  + +           +
Sbjct: 26  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF---VT 82

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKS 601
           AS D+ + V    R+  L  +L +H + +   KF+  DG++ ++S   DK++  +   KS
Sbjct: 83  ASDDKTVKVWATHRQKFLF-SLSQHINWVRCAKFSP-DGRL-IVSASDDKTV--KLWDKS 137

Query: 602 GDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGED 661
                 +   H    T +   D  PS    A    D  ++++++   +  +L +  Q   
Sbjct: 138 SRECVHSYCEHGGFVTYV---DFHPSGTCIAAAGMDNTVKVWDV---RTHRLLQHYQLHS 191

Query: 662 GTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISV 721
             +  +   PSG Y+ T+ SD  L I D   G  + T+ GH    T + FS   ++  S 
Sbjct: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 251

Query: 722 SGDSCIFVWR 731
             D  + VW+
Sbjct: 252 GSDEQVMVWK 261



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 13/168 (7%)

Query: 18  SPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-SGLVAYPAGC--VVVL 74
           SP  +L  S + ++   L  K + E V      GG     D   SG     AG    V +
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 175

Query: 75  FNPRKHK--QHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQE 132
           ++ R H+  QH+ L+S+   +  L+F P G YL+T  S     +++ D+ E   +  L  
Sbjct: 176 WDVRTHRLLQHYQLHSA--AVNGLSFHPSGNYLITASSD--STLKILDLMEGRLLYTLHG 231

Query: 133 HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180
           H+     VAFS + +Y  S G    ++V    WK N  +  +   ++V
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMV----WKSNFDIVDHGEVTKV 275



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 12/161 (7%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           +T + F P G  +    +G    V+VWDV  H  +   Q H   V  ++F PS  Y+++ 
Sbjct: 152 VTYVDFHPSGTCIAA--AGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 209

Query: 153 GYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW-----YLD 206
                + + +   +  ++   +      T V+FS    YF + G +  +  W      +D
Sbjct: 210 SSDSTLKI-LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 268

Query: 207 DSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADS 247
             + +KV      L  S  +G L    F  V  GRG+  +S
Sbjct: 269 HGEVTKVPRPPATLASS--MGNLPEVDF-PVPPGRGRSVES 306



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 34/134 (25%), Positives = 52/134 (38%), Gaps = 6/134 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           V ++ P    +  +  +   T+ ++ F  DG+  VT        V+VW       +  L 
Sbjct: 47  VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK--TVKVWATHRQKFLFSLS 104

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASN-KVSSRVTAVSFSEDCS 190
           +H   V C  FSP  + IVS     D  V +W       V S  +    VT V F    +
Sbjct: 105 QHINWVRCAKFSPDGRLIVSA--SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162

Query: 191 YFVTAG-NRHIKFW 203
               AG +  +K W
Sbjct: 163 CIAAAGMDNTVKVW 176



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 4/88 (4%)

Query: 118 VWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWK-KNIVVASNKV 176
           VW +   S+      HK  V CV FSPS   + S     D  V +W    K         
Sbjct: 7   VWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLAS--GSRDKTVRIWVPNVKGESTVFRAH 64

Query: 177 SSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
           ++ V +V F  D   FVTA  ++ +K W
Sbjct: 65  TATVRSVHFCSDGQSFVTASDDKTVKVW 92



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 54/234 (23%), Positives = 92/234 (39%), Gaps = 27/234 (11%)

Query: 350 LTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACL 409
           + F P+   L+    D ++ +W V + K    V+ A  H++ V SV            C 
Sbjct: 29  VNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRA--HTATVRSVHF----------CS 75

Query: 410 PPSSFITCSSDNTIRLWNTE------SSGVHGSTLHRNILSSDLIKIIYV-DGNTQALLD 462
              SF+T S D T+++W T       S   H + +     S D   I+   D  T  L D
Sbjct: 76  DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135

Query: 463 TELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDS 522
                  +   S  +    +  V   P+G  +A+     T++V ++++   +   + H +
Sbjct: 136 ---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 192

Query: 523 EILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFA 576
            +  L +         L +AS D  + +LD   E  L  TL  H    T V F+
Sbjct: 193 AVNGLSFHPSG---NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFS 242



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 26/113 (23%), Positives = 50/113 (44%), Gaps = 3/113 (2%)

Query: 622 MDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCS 681
           ++  PS    A G +D+ +RI+  +   +  +F+       T+  V     G    T+  
Sbjct: 29  VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQSFVTASD 85

Query: 682 DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
           DK + ++     + + ++  H   V   KFS D + ++S S D  + +W  SS
Sbjct: 86  DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 61/250 (24%), Positives = 107/250 (42%), Gaps = 14/250 (5%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           +  V  SP+G  LASG R  T+R+       E     AH + +  + +           +
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF---VT 120

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKS 601
           AS D+ + V    R+  L  +L +H + +   KF+  DG++ ++S   DK++  +   KS
Sbjct: 121 ASDDKTVKVWATHRQKFLF-SLSQHINWVRCAKFSP-DGRL-IVSASDDKTV--KLWDKS 175

Query: 602 GDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGED 661
                 +   H    T +   D  PS    A    D  ++++++   +  +L +  Q   
Sbjct: 176 SRECVHSYCEHGGFVTYV---DFHPSGTCIAAAGMDNTVKVWDV---RTHRLLQHYQLHS 229

Query: 662 GTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISV 721
             +  +   PSG Y+ T+ SD  L I D   G  + T+ GH    T + FS   ++  S 
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289

Query: 722 SGDSCIFVWR 731
             D  + VW+
Sbjct: 290 GSDEQVMVWK 299



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 13/168 (7%)

Query: 18  SPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-SGLVAYPAGC--VVVL 74
           SP  +L  S + ++   L  K + E V      GG     D   SG     AG    V +
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213

Query: 75  FNPRKHK--QHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQE 132
           ++ R H+  QH+ L+S+   +  L+F P G YL+T  S     +++ D+ E   +  L  
Sbjct: 214 WDVRTHRLLQHYQLHSA--AVNGLSFHPSGNYLITASSD--STLKILDLMEGRLLYTLHG 269

Query: 133 HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180
           H+     VAFS + +Y  S G    ++V    WK N  +  +   ++V
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMV----WKSNFDIVDHGEVTKV 313



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 90  RKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYI 149
           R  +T + FS + K L +G       + VW +   S+      HK  V CV FSPS   +
Sbjct: 19  RDAVTCVDFSINTKQLASGSMDS--CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 150 VSVGYQHDMIVNVWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
            S     D  V +W    K         ++ V +V F  D   FVTA  ++ +K W
Sbjct: 77  AS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 10/177 (5%)

Query: 558 SLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKT 617
           SL++    H  ++T V F+ +  Q+   S  +   ++    Q       +  T H   K 
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----YRFTGH---KD 62

Query: 618 TLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIA 677
            +  ++  PS    A G +D+ +RI+  +   +  +F+       T+  V     G    
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQSFV 119

Query: 678 TSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
           T+  DK + ++     + + ++  H   V   KFS D + ++S S D  + +W  SS
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176



 Score = 39.7 bits (91), Expect = 0.022
 Identities = 25/105 (23%), Positives = 46/105 (43%), Gaps = 3/105 (2%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           +T + F P G  +    +G    V+VWDV  H  +   Q H   V  ++F PS  Y+++ 
Sbjct: 190 VTYVDFHPSGTCIAA--AGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247

Query: 153 GYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGN 197
                + + +   +  ++   +      T V+FS    YF + G+
Sbjct: 248 SSDSTLKI-LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 34/134 (25%), Positives = 52/134 (38%), Gaps = 6/134 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           V ++ P    +  +  +   T+ ++ F  DG+  VT        V+VW       +  L 
Sbjct: 85  VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK--TVKVWATHRQKFLFSLS 142

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASN-KVSSRVTAVSFSEDCS 190
           +H   V C  FSP  + IVS     D  V +W       V S  +    VT V F    +
Sbjct: 143 QHINWVRCAKFSPDGRLIVSA--SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200

Query: 191 YFVTAG-NRHIKFW 203
               AG +  +K W
Sbjct: 201 CIAAAGMDNTVKVW 214



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 54/234 (23%), Positives = 92/234 (39%), Gaps = 27/234 (11%)

Query: 350 LTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACL 409
           + F P+   L+    D ++ +W V + K    V+ A  H++ V SV            C 
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRA--HTATVRSVHF----------CS 113

Query: 410 PPSSFITCSSDNTIRLWNTE------SSGVHGSTLHRNILSSDLIKIIYV-DGNTQALLD 462
              SF+T S D T+++W T       S   H + +     S D   I+   D  T  L D
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 463 TELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDS 522
                  +   S  +    +  V   P+G  +A+     T++V ++++   +   + H +
Sbjct: 174 ---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 230

Query: 523 EILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFA 576
            +  L +         L +AS D  + +LD   E  L  TL  H    T V F+
Sbjct: 231 AVNGLSFHPSG---NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFS 280



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 15/35 (42%), Positives = 21/35 (60%)

Query: 701 GHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 735
           GH + VT + FS + K L S S DSC+ VW +  +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQ 51


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 61/250 (24%), Positives = 107/250 (42%), Gaps = 14/250 (5%)

Query: 482 IRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLAS 541
           +  V  SP+G  LASG R  T+R+       E     AH + +  + +           +
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF---VT 120

Query: 542 ASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKS 601
           AS D+ + V    R+  L  +L +H + +   KF+  DG++ ++S   DK++  +   KS
Sbjct: 121 ASDDKTVKVWATHRQKFLF-SLSQHINWVRCAKFSP-DGRL-IVSASDDKTV--KLWDKS 175

Query: 602 GDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGED 661
                 +   H    T +   D  PS    A    D  ++++++   +  +L +  Q   
Sbjct: 176 SRECVHSYCEHGGFVTYV---DFHPSGTCIAAAGMDNTVKVWDV---RTHRLLQHYQLHS 229

Query: 662 GTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISV 721
             +  +   PSG Y+ T+ SD  L I D   G  + T+ GH    T + FS   ++  S 
Sbjct: 230 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASG 289

Query: 722 SGDSCIFVWR 731
             D  + VW+
Sbjct: 290 GSDEQVMVWK 299



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 13/168 (7%)

Query: 18  SPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-SGLVAYPAGC--VVVL 74
           SP  +L  S + ++   L  K + E V      GG     D   SG     AG    V +
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213

Query: 75  FNPRKHK--QHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQE 132
           ++ R H+  QH+ L+S+   +  L+F P G YL+T  S     +++ D+ E   +  L  
Sbjct: 214 WDVRTHRLLQHYQLHSA--AVNGLSFHPSGNYLITASSD--STLKILDLMEGRLLYTLHG 269

Query: 133 HKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV 180
           H+     VAFS + +Y  S G    ++V    WK N  +  +   ++V
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMV----WKSNFDIVDHGEVTKV 313



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 90  RKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYI 149
           R  +T + FS + K L +G       + VW +   S+      HK  V CV FSPS   +
Sbjct: 19  RDAVTCVDFSINTKQLASGSMDS--CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 150 VSVGYQHDMIVNVWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
            S     D  V +W    K         ++ V +V F  D   FVTA  ++ +K W
Sbjct: 77  AS--GSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 12/161 (7%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           +T + F P G  +    +G    V+VWDV  H  +   Q H   V  ++F PS  Y+++ 
Sbjct: 190 VTYVDFHPSGTCIAA--AGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247

Query: 153 GYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW-----YLD 206
                + + +   +  ++   +      T V+FS    YF + G +  +  W      +D
Sbjct: 248 SSDSTLKI-LDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306

Query: 207 DSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADS 247
             + +KV      L  S  +G L    F  V  GRG+  +S
Sbjct: 307 HGEVTKVPRPPATLASS--MGNLPEVDF-PVPPGRGRSVES 344



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 10/177 (5%)

Query: 558 SLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKT 617
           SL++    H  ++T V F+ +  Q+   S  +   ++    Q       +  T H   K 
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA----YRFTGH---KD 62

Query: 618 TLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIA 677
            +  ++  PS    A G +D+ +RI+  +   +  +F+       T+  V     G    
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA---HTATVRSVHFCSDGQSFV 119

Query: 678 TSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
           T+  DK + ++     + + ++  H   V   KFS D + ++S S D  + +W  SS
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 34/134 (25%), Positives = 52/134 (38%), Gaps = 6/134 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           V ++ P    +  +  +   T+ ++ F  DG+  VT        V+VW       +  L 
Sbjct: 85  VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK--TVKVWATHRQKFLFSLS 142

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASN-KVSSRVTAVSFSEDCS 190
           +H   V C  FSP  + IVS     D  V +W       V S  +    VT V F    +
Sbjct: 143 QHINWVRCAKFSPDGRLIVSA--SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200

Query: 191 YFVTAG-NRHIKFW 203
               AG +  +K W
Sbjct: 201 CIAAAGMDNTVKVW 214



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 54/234 (23%), Positives = 92/234 (39%), Gaps = 27/234 (11%)

Query: 350 LTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACL 409
           + F P+   L+    D ++ +W V + K    V+ A  H++ V SV            C 
Sbjct: 67  VNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRA--HTATVRSVHF----------CS 113

Query: 410 PPSSFITCSSDNTIRLWNTE------SSGVHGSTLHRNILSSDLIKIIYV-DGNTQALLD 462
              SF+T S D T+++W T       S   H + +     S D   I+   D  T  L D
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173

Query: 463 TELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDS 522
                  +   S  +    +  V   P+G  +A+     T++V ++++   +   + H +
Sbjct: 174 ---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA 230

Query: 523 EILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFA 576
            +  L +         L +AS D  + +LD   E  L  TL  H    T V F+
Sbjct: 231 AVNGLSFHPSG---NYLITASSDSTLKILDL-MEGRLLYTLHGHQGPATTVAFS 280



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 15/35 (42%), Positives = 21/35 (60%)

Query: 701 GHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 735
           GH + VT + FS + K L S S DSC+ VW +  +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQ 51


>gi|223029510 echinoderm microtubule associated protein like 4
           isoform b [Homo sapiens]
          Length = 923

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 60/211 (28%), Positives = 92/211 (43%), Gaps = 20/211 (9%)

Query: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-----SGLVAY 66
           IK  +R   I +      +  +D+ +++  EK+      G RG  C        +G + Y
Sbjct: 169 IKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVY 228

Query: 67  PAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------PAVRV 118
               VVVLFN  +  Q H L  +   +  LA  PD   + TG+   +        P VRV
Sbjct: 229 FIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRV 287

Query: 119 WDVAEHS--QVAELQEHKYGVACVAFS--PSAKYIVSVGYQHDMIVNVWAWKKNIVVASN 174
           WD    S  Q+  L   + GV C+ FS   S  ++  +   ++ ++ VW W+K    A  
Sbjct: 288 WDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEI 347

Query: 175 KVSSRVT-AVSF-SEDCSYFVTAGNRHIKFW 203
           K ++ V  AV F   D +  +T G  HI FW
Sbjct: 348 KTTNEVVLAVEFHPTDANTIITCGKSHIFFW 378



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 72/328 (21%), Positives = 134/328 (40%), Gaps = 46/328 (14%)

Query: 489 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC-LEYSKPDTGLKLLASASRDRL 547
           P+G  +A G   G   V + ++  +++ +    +E L  + YS   T    LA  S D  
Sbjct: 585 PSGTVVAIGTHSGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSIDGT---FLAVGSHDNF 640

Query: 548 IH---VLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDG 604
           I+   V + GR+YS       HSS IT + ++  D +  M + G  + +Y+       +G
Sbjct: 641 IYLYVVSENGRKYSRYGRCTGHSSYITHLDWSP-DNKYIMSNSGDYEILYWDIP----NG 695

Query: 605 VQFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGT 663
            +  R      ++   D+D    W  YT +       ++F +         +GS G D  
Sbjct: 696 CKLIRN-----RSDCKDID----WTTYTCV----LGFQVFGVWP-------EGSDGTDIN 735

Query: 664 LIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVS 722
            +    +   I +A      +L  +  S  +  +  +  HS  VT + F+++  HLIS  
Sbjct: 736 ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTG 795

Query: 723 G-DSCIFVWRLSSEMTISMRQRLAE-------LRQRQRGGKQQGPSSPQRASGPNRHQAP 774
           G D  I  W+L  ++++   + +A+       +   +   +   P+ P         +  
Sbjct: 796 GKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEE 855

Query: 775 SMLSPGPAL---SSDSDKEGEDEGTEEE 799
           S +S  P L   S +   E  ++ +EEE
Sbjct: 856 SRISSSPTLLENSLEQTVEPSEDHSEEE 883



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 82/393 (20%), Positives = 150/393 (38%), Gaps = 57/393 (14%)

Query: 364 NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTI 423
           N+H + VWD +   K  ++ +    +  V +VE +P   ++   C     F    S N++
Sbjct: 329 NEHMLTVWDWQKKAKGAEIKTT---NEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSL 385

Query: 424 RLWNTESSGVHGSTL------------HRNILSSDLIKIIYVDGNTQALLDTELPGGDKA 471
               T   G+ G               + ++L+ D   ++ +   T        PG    
Sbjct: 386 ----TRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTV---EPTPGKGPK 438

Query: 472 DASLLDPRV-----GIRSVCVSPNGQHLASG--DRMGTLRVHELQSLSEMLKVEAHDSEI 524
               +  ++      + ++C   NG  L  G  DR   L  H+L    E ++V      I
Sbjct: 439 GVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPERE-IEVPDQYGTI 497

Query: 525 LCLEYSKPDTGLKLLASASRDRLIH-VLDAGREYSLQQTLDEHSSSIT-----AVKFAAS 578
             +   K D   + L   SR+ ++    + G +  +Q   DE     T      +   A 
Sbjct: 498 RAVAEGKAD---QFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQ 554

Query: 579 DGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 638
           D QV + +    +  + R   + G    F  +  VV   T        S ++  +  + R
Sbjct: 555 DRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGT-------HSGRWFVLDAETR 607

Query: 639 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYI-ATSCSDKNLSIFDFSSGECVA 697
           ++   +    +Q  + + S   DGT + V +  + IY+   S + +  S +    G C  
Sbjct: 608 DLVSIHTDGNEQLSVMRYSI--DGTFLAVGSHDNFIYLYVVSENGRKYSRY----GRCT- 660

Query: 698 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 730
              GHS  +T + +S D K+++S SGD  I  W
Sbjct: 661 ---GHSSYITHLDWSPDNKYIMSNSGDYEILYW 690


>gi|19923497 echinoderm microtubule associated protein like 4
           isoform a [Homo sapiens]
          Length = 981

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 60/211 (28%), Positives = 92/211 (43%), Gaps = 20/211 (9%)

Query: 12  IKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR-----SGLVAY 66
           IK  +R   I +      +  +D+ +++  EK+      G RG  C        +G + Y
Sbjct: 227 IKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVY 286

Query: 67  PAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHM--------PAVRV 118
               VVVLFN  +  Q H L  +   +  LA  PD   + TG+   +        P VRV
Sbjct: 287 FIASVVVLFNYEERTQRHYLGHT-DCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRV 345

Query: 119 WDVAEHS--QVAELQEHKYGVACVAFS--PSAKYIVSVGYQHDMIVNVWAWKKNIVVASN 174
           WD    S  Q+  L   + GV C+ FS   S  ++  +   ++ ++ VW W+K    A  
Sbjct: 346 WDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEI 405

Query: 175 KVSSRVT-AVSF-SEDCSYFVTAGNRHIKFW 203
           K ++ V  AV F   D +  +T G  HI FW
Sbjct: 406 KTTNEVVLAVEFHPTDANTIITCGKSHIFFW 436



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 72/328 (21%), Positives = 134/328 (40%), Gaps = 46/328 (14%)

Query: 489 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC-LEYSKPDTGLKLLASASRDRL 547
           P+G  +A G   G   V + ++  +++ +    +E L  + YS   T    LA  S D  
Sbjct: 643 PSGTVVAIGTHSGRWFVLDAET-RDLVSIHTDGNEQLSVMRYSIDGT---FLAVGSHDNF 698

Query: 548 IH---VLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDG 604
           I+   V + GR+YS       HSS IT + ++  D +  M + G  + +Y+       +G
Sbjct: 699 IYLYVVSENGRKYSRYGRCTGHSSYITHLDWSP-DNKYIMSNSGDYEILYWDIP----NG 753

Query: 605 VQFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGT 663
            +  R      ++   D+D    W  YT +       ++F +         +GS G D  
Sbjct: 754 CKLIRN-----RSDCKDID----WTTYTCV----LGFQVFGVWP-------EGSDGTDIN 793

Query: 664 LIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVS 722
            +    +   I +A      +L  +  S  +  +  +  HS  VT + F+++  HLIS  
Sbjct: 794 ALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTG 853

Query: 723 G-DSCIFVWRLSSEMTISMRQRLAE-------LRQRQRGGKQQGPSSPQRASGPNRHQAP 774
           G D  I  W+L  ++++   + +A+       +   +   +   P+ P         +  
Sbjct: 854 GKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEE 913

Query: 775 SMLSPGPAL---SSDSDKEGEDEGTEEE 799
           S +S  P L   S +   E  ++ +EEE
Sbjct: 914 SRISSSPTLLENSLEQTVEPSEDHSEEE 941



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 82/393 (20%), Positives = 150/393 (38%), Gaps = 57/393 (14%)

Query: 364 NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTI 423
           N+H + VWD +   K  ++ +    +  V +VE +P   ++   C     F    S N++
Sbjct: 387 NEHMLTVWDWQKKAKGAEIKTT---NEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSL 443

Query: 424 RLWNTESSGVHGSTL------------HRNILSSDLIKIIYVDGNTQALLDTELPGGDKA 471
               T   G+ G               + ++L+ D   ++ +   T        PG    
Sbjct: 444 ----TRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTV---EPTPGKGPK 496

Query: 472 DASLLDPRV-----GIRSVCVSPNGQHLASG--DRMGTLRVHELQSLSEMLKVEAHDSEI 524
               +  ++      + ++C   NG  L  G  DR   L  H+L    E ++V      I
Sbjct: 497 GVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPERE-IEVPDQYGTI 555

Query: 525 LCLEYSKPDTGLKLLASASRDRLIH-VLDAGREYSLQQTLDEHSSSIT-----AVKFAAS 578
             +   K D   + L   SR+ ++    + G +  +Q   DE     T      +   A 
Sbjct: 556 RAVAEGKAD---QFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQ 612

Query: 579 DGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 638
           D QV + +    +  + R   + G    F  +  VV   T        S ++  +  + R
Sbjct: 613 DRQVCLWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGT-------HSGRWFVLDAETR 665

Query: 639 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYI-ATSCSDKNLSIFDFSSGECVA 697
           ++   +    +Q  + + S   DGT + V +  + IY+   S + +  S +    G C  
Sbjct: 666 DLVSIHTDGNEQLSVMRYSI--DGTFLAVGSHDNFIYLYVVSENGRKYSRY----GRCT- 718

Query: 698 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 730
              GHS  +T + +S D K+++S SGD  I  W
Sbjct: 719 ---GHSSYITHLDWSPDNKYIMSNSGDYEILYW 748


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 122/665 (18%), Positives = 236/665 (35%), Gaps = 117/665 (17%)

Query: 98   FSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHD 157
            FS DG+ + +   G    ++V+      ++ E++ H+  V C AFS   ++I +     D
Sbjct: 623  FSEDGQRIAS--CGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV--D 678

Query: 158  MIVNVW-AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA---GNRHIKFWYLDDSKTSKV 213
              V +W +    +V   ++ S +V    F+    + + A    +  +K W L+  +    
Sbjct: 679  KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 738

Query: 214  NATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELR 273
                 + G +  +   R +   D        AD T  +  +    E     +   ++ L 
Sbjct: 739  -----MFGHTNSVNHCRFS--PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 791

Query: 274  NIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEAS 333
            +       +  C S S        ADG   +    N  FL  +                S
Sbjct: 792  DPQEDMEVIVKCCSWS--------ADGARIMVAAKNKIFLFDI--------------HTS 829

Query: 334  RLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVW 393
             L   +    +       F P N       + + + +W+     KV        H S V 
Sbjct: 830  GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVH 886

Query: 394  SVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRN----ILSSDLIK 449
             V   P+           SSF+T S D TIRLW T+    + + + +     +   + + 
Sbjct: 887  GVMFSPD----------GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM 936

Query: 450  IIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQ 509
            ++ VD     +   +L  G       L     +   C+SP+ Q++A GD  G + + EL 
Sbjct: 937  VLAVD----HIRRLQLINGRTGQIDYL-TEAQVSCCCLSPHLQYIAFGDENGAIEILELV 991

Query: 510  SLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSS 569
            +         H   +  ++++  +   K L S+S                          
Sbjct: 992  NNRIFQSRFQHKKTVWHIQFTADE---KTLISSS-------------------------- 1022

Query: 570  ITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWK 629
                     D ++++ +   DK I+ R  Q++    +  +   ++            SW 
Sbjct: 1023 --------DDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL------------SWS 1062

Query: 630  YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFD 689
            +      D  ++++NI +G ++K F   Q   GT++           +++ +DK   I+ 
Sbjct: 1063 F------DGTVKVWNIITGNKEKDFVCHQ---GTVLSCDISHDATKFSSTSADKTAKIWS 1113

Query: 690  FSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQ 749
            F     +  + GH+  V    FS D   L +   +  I +W +S+   + +   L+E   
Sbjct: 1114 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173

Query: 750  RQRGG 754
               GG
Sbjct: 1174 ATHGG 1178



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 23/266 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C S +GQ +AS     TL+V + ++  ++L+++AH+ E+LC  +S  D   + +A+ S D
Sbjct: 622 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD---RFIATCSVD 678

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSI-YFRTAQKSGDG 604
           + + + ++     L  T DEHS  +    F  S   + + +  +D  +  +   QK    
Sbjct: 679 KKVKIWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 737

Query: 605 VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQ------ 658
             F  T+ V            P  K  A    D  +++++ +S  ++K     Q      
Sbjct: 738 TMFGHTNSV------NHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 791

Query: 659 --GEDGTLIK--VQTDPSGIYIATSCSDKNLSIFDF-SSGECVATMFGHSEIVTGMKFSN 713
              ED  +I         G  I  +  +K + +FD  +SG       GH   +    FS 
Sbjct: 792 DPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850

Query: 714 DCKHLISVSGDSCIFVWRLSSEMTIS 739
                +      C+ +W   S   ++
Sbjct: 851 QNHLAVVALSQYCVELWNTDSRSKVA 876



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 10/88 (11%)

Query: 80  HKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVAC 139
           H  HH       TI    FSP     V   S +   V +W+    S+VA+ + H   V  
Sbjct: 836 HTGHH------STIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVHG 887

Query: 140 VAFSPSAKYIVSVGYQHDMIVNVWAWKK 167
           V FSP     ++     D  + +W  KK
Sbjct: 888 VMFSPDGSSFLT--SSDDQTIRLWETKK 913


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 122/665 (18%), Positives = 236/665 (35%), Gaps = 117/665 (17%)

Query: 98   FSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHD 157
            FS DG+ + +   G    ++V+      ++ E++ H+  V C AFS   ++I +     D
Sbjct: 612  FSEDGQRIAS--CGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV--D 667

Query: 158  MIVNVW-AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA---GNRHIKFWYLDDSKTSKV 213
              V +W +    +V   ++ S +V    F+    + + A    +  +K W L+  +    
Sbjct: 668  KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 727

Query: 214  NATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELR 273
                 + G +  +   R +   D        AD T  +  +    E     +   ++ L 
Sbjct: 728  -----MFGHTNSVNHCRFS--PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780

Query: 274  NIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEAS 333
            +       +  C S S        ADG   +    N  FL  +                S
Sbjct: 781  DPQEDMEVIVKCCSWS--------ADGARIMVAAKNKIFLFDI--------------HTS 818

Query: 334  RLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVW 393
             L   +    +       F P N       + + + +W+     KV        H S V 
Sbjct: 819  GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVH 875

Query: 394  SVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRN----ILSSDLIK 449
             V   P+           SSF+T S D TIRLW T+    + + + +     +   + + 
Sbjct: 876  GVMFSPD----------GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM 925

Query: 450  IIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQ 509
            ++ VD     +   +L  G       L     +   C+SP+ Q++A GD  G + + EL 
Sbjct: 926  VLAVD----HIRRLQLINGRTGQIDYL-TEAQVSCCCLSPHLQYIAFGDENGAIEILELV 980

Query: 510  SLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSS 569
            +         H   +  ++++  +   K L S+S                          
Sbjct: 981  NNRIFQSRFQHKKTVWHIQFTADE---KTLISSS-------------------------- 1011

Query: 570  ITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWK 629
                     D ++++ +   DK I+ R  Q++    +  +   ++            SW 
Sbjct: 1012 --------DDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL------------SWS 1051

Query: 630  YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFD 689
            +      D  ++++NI +G ++K F   Q   GT++           +++ +DK   I+ 
Sbjct: 1052 F------DGTVKVWNIITGNKEKDFVCHQ---GTVLSCDISHDATKFSSTSADKTAKIWS 1102

Query: 690  FSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQ 749
            F     +  + GH+  V    FS D   L +   +  I +W +S+   + +   L+E   
Sbjct: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162

Query: 750  RQRGG 754
               GG
Sbjct: 1163 ATHGG 1167



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 23/266 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C S +GQ +AS     TL+V + ++  ++L+++AH+ E+LC  +S  D   + +A+ S D
Sbjct: 611 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD---RFIATCSVD 667

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSI-YFRTAQKSGDG 604
           + + + ++     L  T DEHS  +    F  S   + + +  +D  +  +   QK    
Sbjct: 668 KKVKIWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726

Query: 605 VQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQ------ 658
             F  T+ V            P  K  A    D  +++++ +S  ++K     Q      
Sbjct: 727 TMFGHTNSV------NHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780

Query: 659 --GEDGTLIK--VQTDPSGIYIATSCSDKNLSIFDF-SSGECVATMFGHSEIVTGMKFSN 713
              ED  +I         G  I  +  +K + +FD  +SG       GH   +    FS 
Sbjct: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839

Query: 714 DCKHLISVSGDSCIFVWRLSSEMTIS 739
                +      C+ +W   S   ++
Sbjct: 840 QNHLAVVALSQYCVELWNTDSRSKVA 865



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 10/88 (11%)

Query: 80  HKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVAC 139
           H  HH       TI    FSP     V   S +   V +W+    S+VA+ + H   V  
Sbjct: 825 HTGHH------STIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVHG 876

Query: 140 VAFSPSAKYIVSVGYQHDMIVNVWAWKK 167
           V FSP     ++     D  + +W  KK
Sbjct: 877 VMFSPDGSSFLT--SSDDQTIRLWETKK 902


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 58/247 (23%), Positives = 110/247 (44%), Gaps = 21/247 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C+  + Q + SG R  T+++ +  +L     +  H   +LCL+Y +     +++ + S D
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE-----RVIITGSSD 326

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
             + V D      L  TL  H  ++  ++F  ++G   M++C  D+SI         D  
Sbjct: 327 STVRVWDVNTGEMLN-TLIHHCEAVLHLRF--NNGM--MVTCSKDRSIAVWDMASPTDIT 381

Query: 606 QFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
              R   V  +  +  +D +  +  +A G  DR I+++N S+ +  +   G +     L 
Sbjct: 382 --LRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACL- 436

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
                     + +  SD  + ++D   G C+  + GH E+V  ++F N  K ++S + D 
Sbjct: 437 ----QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDG 490

Query: 726 CIFVWRL 732
            I VW L
Sbjct: 491 KIKVWDL 497



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 31/111 (27%), Positives = 62/111 (55%), Gaps = 7/111 (6%)

Query: 634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG 693
           G +D  I+I++ ++ + K++  G     G+++ +Q D     I T  SD  + ++D ++G
Sbjct: 283 GLRDNTIKIWDKNTLECKRILTG---HTGSVLCLQYDER--VIITGSSDSTVRVWDVNTG 337

Query: 694 ECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRL 744
           E + T+  H E V  ++F+N    +++ S D  I VW ++S   I++R+ L
Sbjct: 338 EMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWDMASPTDITLRRVL 386



 Score = 38.9 bits (89), Expect = 0.038
 Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 20/182 (10%)

Query: 415 ITCSSDNTIRLWNTESSGVHGSTLHR-----NILSSDLIKIIYVDGNTQALLDTELPGGD 469
           IT SSD+T+R+W+  +  +  + +H      ++  ++ + +      + A+ D   P   
Sbjct: 321 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDI 380

Query: 470 KADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEY 529
                L+  R  +  V         ASGDR  T++V    +   +  +  H   I CL+Y
Sbjct: 381 TLRRVLVGHRAAVNVVDFDDKYIVSASGDR--TIKVWNTSTCEFVRTLNGHKRGIACLQY 438

Query: 530 SKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF-------AASDGQV 582
                  +L+ S S D  I + D      L + L+ H   +  ++F        A DG++
Sbjct: 439 RD-----RLVVSGSSDNTIRLWDIECGACL-RVLEGHEELVRCIRFDNKRIVSGAYDGKI 492

Query: 583 RM 584
           ++
Sbjct: 493 KV 494



 Score = 38.5 bits (88), Expect = 0.050
 Identities = 71/321 (22%), Positives = 119/321 (37%), Gaps = 83/321 (25%)

Query: 252 TSSGLLC-EFSDRRLLDK--------W----VELRNIDSFTTTVAHCISVSQDYIFCGCA 298
           TS G+ C ++ D++++          W    +E + I +  T    C+   +  I  G +
Sbjct: 266 TSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSS 325

Query: 299 DGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQW 358
           D TVR+++ +    L+TL   H                  V + R+ + + +T       
Sbjct: 326 DSTVRVWDVNTGEMLNTLIH-HC---------------EAVLHLRFNNGMMVTCS----- 364

Query: 359 LSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCV---------------------WSVEV 397
                 D SI VWD+  P  +      + H + V                     W+   
Sbjct: 365 -----KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST 419

Query: 398 YPEVKDSNQ-----ACLPPSS--FITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKI 450
              V+  N      ACL       ++ SSDNTIRLW+ E     G+ L       +L++ 
Sbjct: 420 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIEC----GACLRVLEGHEELVRC 475

Query: 451 IYVDGN--TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL 508
           I  D         D ++   D   A  LDPR    ++C+    +H     R+  L+  E 
Sbjct: 476 IRFDNKRIVSGAYDGKIKVWDLVAA--LDPRAPAGTLCLRTLVEH---SGRVFRLQFDEF 530

Query: 509 QSLSEMLKVEAHDSEILCLEY 529
           Q +S      +HD  IL  ++
Sbjct: 531 QIVS-----SSHDDTILIWDF 546



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 22/101 (21%), Positives = 41/101 (40%), Gaps = 10/101 (9%)

Query: 42  EKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPD 101
           E VL +  + G  + C     +  +       + +P       +L   R  +  + F  D
Sbjct: 348 EAVLHLRFNNGMMVTCSKDRSIAVWD------MASPTDITLRRVLVGHRAAVNVVDF--D 399

Query: 102 GKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAF 142
            KY+V+        ++VW+ +    V  L  HK G+AC+ +
Sbjct: 400 DKYIVSASGDR--TIKVWNTSTCEFVRTLNGHKRGIACLQY 438


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 58/247 (23%), Positives = 110/247 (44%), Gaps = 21/247 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C+  + Q + SG R  T+++ +  +L     +  H   +LCL+Y +     +++ + S D
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE-----RVIITGSSD 362

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
             + V D      L  TL  H  ++  ++F  ++G   M++C  D+SI         D  
Sbjct: 363 STVRVWDVNTGEMLN-TLIHHCEAVLHLRF--NNGM--MVTCSKDRSIAVWDMASPTDIT 417

Query: 606 QFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
              R   V  +  +  +D +  +  +A G  DR I+++N S+ +  +   G +     L 
Sbjct: 418 --LRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWNTSTCEFVRTLNGHKRGIACL- 472

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
                     + +  SD  + ++D   G C+  + GH E+V  ++F N  K ++S + D 
Sbjct: 473 ----QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDG 526

Query: 726 CIFVWRL 732
            I VW L
Sbjct: 527 KIKVWDL 533



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 31/111 (27%), Positives = 62/111 (55%), Gaps = 7/111 (6%)

Query: 634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG 693
           G +D  I+I++ ++ + K++  G     G+++ +Q D     I T  SD  + ++D ++G
Sbjct: 319 GLRDNTIKIWDKNTLECKRILTG---HTGSVLCLQYDER--VIITGSSDSTVRVWDVNTG 373

Query: 694 ECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRL 744
           E + T+  H E V  ++F+N    +++ S D  I VW ++S   I++R+ L
Sbjct: 374 EMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWDMASPTDITLRRVL 422



 Score = 38.9 bits (89), Expect = 0.038
 Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 20/182 (10%)

Query: 415 ITCSSDNTIRLWNTESSGVHGSTLHR-----NILSSDLIKIIYVDGNTQALLDTELPGGD 469
           IT SSD+T+R+W+  +  +  + +H      ++  ++ + +      + A+ D   P   
Sbjct: 357 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDI 416

Query: 470 KADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEY 529
                L+  R  +  V         ASGDR  T++V    +   +  +  H   I CL+Y
Sbjct: 417 TLRRVLVGHRAAVNVVDFDDKYIVSASGDR--TIKVWNTSTCEFVRTLNGHKRGIACLQY 474

Query: 530 SKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF-------AASDGQV 582
                  +L+ S S D  I + D      L + L+ H   +  ++F        A DG++
Sbjct: 475 RD-----RLVVSGSSDNTIRLWDIECGACL-RVLEGHEELVRCIRFDNKRIVSGAYDGKI 528

Query: 583 RM 584
           ++
Sbjct: 529 KV 530



 Score = 38.5 bits (88), Expect = 0.050
 Identities = 71/321 (22%), Positives = 119/321 (37%), Gaps = 83/321 (25%)

Query: 252 TSSGLLC-EFSDRRLLDK--------W----VELRNIDSFTTTVAHCISVSQDYIFCGCA 298
           TS G+ C ++ D++++          W    +E + I +  T    C+   +  I  G +
Sbjct: 302 TSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSS 361

Query: 299 DGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQW 358
           D TVR+++ +    L+TL   H                  V + R+ + + +T       
Sbjct: 362 DSTVRVWDVNTGEMLNTLIH-HC---------------EAVLHLRFNNGMMVTCS----- 400

Query: 359 LSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCV---------------------WSVEV 397
                 D SI VWD+  P  +      + H + V                     W+   
Sbjct: 401 -----KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTST 455

Query: 398 YPEVKDSNQ-----ACLPPSS--FITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKI 450
              V+  N      ACL       ++ SSDNTIRLW+ E     G+ L       +L++ 
Sbjct: 456 CEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIEC----GACLRVLEGHEELVRC 511

Query: 451 IYVDGN--TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL 508
           I  D         D ++   D   A  LDPR    ++C+    +H     R+  L+  E 
Sbjct: 512 IRFDNKRIVSGAYDGKIKVWDLVAA--LDPRAPAGTLCLRTLVEH---SGRVFRLQFDEF 566

Query: 509 QSLSEMLKVEAHDSEILCLEY 529
           Q +S      +HD  IL  ++
Sbjct: 567 QIVS-----SSHDDTILIWDF 582



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 22/101 (21%), Positives = 41/101 (40%), Gaps = 10/101 (9%)

Query: 42  EKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPD 101
           E VL +  + G  + C     +  +       + +P       +L   R  +  + F  D
Sbjct: 384 EAVLHLRFNNGMMVTCSKDRSIAVWD------MASPTDITLRRVLVGHRAAVNVVDF--D 435

Query: 102 GKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAF 142
            KY+V+        ++VW+ +    V  L  HK G+AC+ +
Sbjct: 436 DKYIVSASGDR--TIKVWNTSTCEFVRTLNGHKRGIACLQY 474


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 21/251 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C+  + + + SG R  ++++ +  SL  +  +  H   +LCL+Y +     +++ + S D
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE-----RVIVTGSSD 299

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
             + V D      L  TL  H+ ++  ++F  S+G   M++C  D+SI       + D  
Sbjct: 300 STVRVWDVNTGEVLN-TLIHHNEAVLHLRF--SNGL--MVTCSKDRSIAVWDMASATDIT 354

Query: 606 QFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
              R   V  +  +  +D +  +  +A G  DR I++++ S+ +  +   G +     L 
Sbjct: 355 --LRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACL- 409

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
                     + +  SD  + ++D   G C+  + GH E+V  ++F N  K ++S + D 
Sbjct: 410 ----QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDG 463

Query: 726 CIFVWRLSSEM 736
            I VW L + +
Sbjct: 464 KIKVWDLQAAL 474



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 33/111 (29%), Positives = 63/111 (56%), Gaps = 7/111 (6%)

Query: 634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG 693
           G +D +I+I++ +S +  K+  G     G+++ +Q D     I T  SD  + ++D ++G
Sbjct: 256 GLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTG 310

Query: 694 ECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRL 744
           E + T+  H+E V  ++FSN    +++ S D  I VW ++S   I++R+ L
Sbjct: 311 EVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVL 359



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 26/185 (14%)

Query: 415 ITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDG-NTQALLDTELPGGDKADA 473
           +T SSD+T+R+W+  +  V  + +H N     ++ + + +G       D  +   D A A
Sbjct: 294 VTGSSDSTVRVWDVNTGEVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASA 350

Query: 474 S-------LLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC 526
           +       L+  R  +  V         ASGDR  T++V    +   +  +  H   I C
Sbjct: 351 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR--TIKVWSTSTCEFVRTLNGHKRGIAC 408

Query: 527 LEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF-------AASD 579
           L+Y       +L+ S S D  I + D      L + L+ H   +  ++F        A D
Sbjct: 409 LQYRD-----RLVVSGSSDNTIRLWDIECGACL-RVLEGHEELVRCIRFDNKRIVSGAYD 462

Query: 580 GQVRM 584
           G++++
Sbjct: 463 GKIKV 467



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 35/115 (30%), Positives = 46/115 (40%), Gaps = 9/115 (7%)

Query: 92  TITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVS 151
           T + L    D + +VTG S     VRVWDV     +  L  H   V  + FS      + 
Sbjct: 280 TGSVLCLQYDERVIVTGSSDS--TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LM 333

Query: 152 VGYQHDMIVNVW--AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA-GNRHIKFW 203
           V    D  + VW  A   +I +    V  R        D  Y V+A G+R IK W
Sbjct: 334 VTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW 388


>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
           sapiens]
          Length = 649

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 54/183 (29%), Positives = 75/183 (40%), Gaps = 20/183 (10%)

Query: 49  VSGGRGLACDPR-----SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
           V G RG  C        +G + Y    V VL++  + +Q H L  +   I  LA  PD  
Sbjct: 60  VYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHN-DDIKCLAIHPDMV 118

Query: 104 YLVTGESGHM--------PAVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVS 151
            + TG+            P VR+WD    S   V  L      V CV FS S     + +
Sbjct: 119 TIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCA 178

Query: 152 VGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVS--FSEDCSYFVTAGNRHIKFWYLDDSK 209
           V   +D +++VW W K   V   K S+    V+     D +  +T G  HI FW L+   
Sbjct: 179 VDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGS 238

Query: 210 TSK 212
            SK
Sbjct: 239 LSK 241



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 30/181 (16%)

Query: 367 SIYVWDVRDPKKVGKVYSALY-----HSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDN 421
           ++YV   R+    G V++        H   +W +  +P            + F+TC  D 
Sbjct: 350 TLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPS----------RAQFVTCGQDK 399

Query: 422 TIRLWNTESSGVHGSTLHRNIL-------SSDLIKIIYVDGNTQALLDTELPGGDKADAS 474
            + LW+++S     S +  +         S  ++ +  V G    LLDTE        A 
Sbjct: 400 LVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGR-WLLLDTET---HDLVAI 455

Query: 475 LLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL----QSLSEMLKVEAHDSEILCLEYS 530
             D    I  V  SP+G +LA G     + V+ +    + +S + K   H S I  L+++
Sbjct: 456 HTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWA 515

Query: 531 K 531
           +
Sbjct: 516 Q 516



 Score = 31.6 bits (70), Expect = 6.1
 Identities = 17/68 (25%), Positives = 28/68 (41%), Gaps = 4/68 (5%)

Query: 667 VQTDPSGIYIATSCSDKNLSIFDFSSG----ECVATMFGHSEIVTGMKFSNDCKHLISVS 722
           V   P G Y+A    D  + ++    G      +    GHS  +T + ++ D    ++ S
Sbjct: 466 VSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNS 525

Query: 723 GDSCIFVW 730
           GD  I  W
Sbjct: 526 GDYEILYW 533


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 21/251 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C+  + + + SG R  ++++ +  SL  +  +  H   +LCL+Y +     +++ + S D
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE-----RVIVTGSSD 265

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
             + V D      L  TL  H+ ++  ++F  S+G   M++C  D+SI       + D  
Sbjct: 266 STVRVWDVNTGEVLN-TLIHHNEAVLHLRF--SNGL--MVTCSKDRSIAVWDMASATDIT 320

Query: 606 QFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
              R   V  +  +  +D +  +  +A G  DR I++++ S+ +  +   G +     L 
Sbjct: 321 --LRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACL- 375

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
                     + +  SD  + ++D   G C+  + GH E+V  ++F N  K ++S + D 
Sbjct: 376 ----QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDG 429

Query: 726 CIFVWRLSSEM 736
            I VW L + +
Sbjct: 430 KIKVWDLQAAL 440



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 33/111 (29%), Positives = 63/111 (56%), Gaps = 7/111 (6%)

Query: 634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG 693
           G +D +I+I++ +S +  K+  G     G+++ +Q D     I T  SD  + ++D ++G
Sbjct: 222 GLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTG 276

Query: 694 ECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRL 744
           E + T+  H+E V  ++FSN    +++ S D  I VW ++S   I++R+ L
Sbjct: 277 EVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVL 325



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 26/185 (14%)

Query: 415 ITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDG-NTQALLDTELPGGDKADA 473
           +T SSD+T+R+W+  +  V  + +H N     ++ + + +G       D  +   D A A
Sbjct: 260 VTGSSDSTVRVWDVNTGEVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASA 316

Query: 474 S-------LLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC 526
           +       L+  R  +  V         ASGDR  T++V    +   +  +  H   I C
Sbjct: 317 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR--TIKVWSTSTCEFVRTLNGHKRGIAC 374

Query: 527 LEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF-------AASD 579
           L+Y       +L+ S S D  I + D      L + L+ H   +  ++F        A D
Sbjct: 375 LQYRD-----RLVVSGSSDNTIRLWDIECGACL-RVLEGHEELVRCIRFDNKRIVSGAYD 428

Query: 580 GQVRM 584
           G++++
Sbjct: 429 GKIKV 433



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 35/115 (30%), Positives = 46/115 (40%), Gaps = 9/115 (7%)

Query: 92  TITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVS 151
           T + L    D + +VTG S     VRVWDV     +  L  H   V  + FS      + 
Sbjct: 246 TGSVLCLQYDERVIVTGSSDS--TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LM 299

Query: 152 VGYQHDMIVNVW--AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA-GNRHIKFW 203
           V    D  + VW  A   +I +    V  R        D  Y V+A G+R IK W
Sbjct: 300 VTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW 354


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 21/251 (8%)

Query: 486 CVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRD 545
           C+  + + + SG R  ++++ +  SL  +  +  H   +LCL+Y +     +++ + S D
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE-----RVIVTGSSD 286

Query: 546 RLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
             + V D      L  TL  H+ ++  ++F  S+G   M++C  D+SI       + D  
Sbjct: 287 STVRVWDVNTGEVLN-TLIHHNEAVLHLRF--SNGL--MVTCSKDRSIAVWDMASATDIT 341

Query: 606 QFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
              R   V  +  +  +D +  +  +A G  DR I++++ S+ +  +   G +     L 
Sbjct: 342 --LRRVLVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACL- 396

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
                     + +  SD  + ++D   G C+  + GH E+V  ++F N  K ++S + D 
Sbjct: 397 ----QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYDG 450

Query: 726 CIFVWRLSSEM 736
            I VW L + +
Sbjct: 451 KIKVWDLQAAL 461



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 33/111 (29%), Positives = 63/111 (56%), Gaps = 7/111 (6%)

Query: 634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSG 693
           G +D +I+I++ +S +  K+  G     G+++ +Q D     I T  SD  + ++D ++G
Sbjct: 243 GLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTG 297

Query: 694 ECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRL 744
           E + T+  H+E V  ++FSN    +++ S D  I VW ++S   I++R+ L
Sbjct: 298 EVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVL 346



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 43/185 (23%), Positives = 78/185 (42%), Gaps = 26/185 (14%)

Query: 415 ITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDG-NTQALLDTELPGGDKADA 473
           +T SSD+T+R+W+  +  V  + +H N     ++ + + +G       D  +   D A A
Sbjct: 281 VTGSSDSTVRVWDVNTGEVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASA 337

Query: 474 S-------LLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILC 526
           +       L+  R  +  V         ASGDR  T++V    +   +  +  H   I C
Sbjct: 338 TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR--TIKVWSTSTCEFVRTLNGHKRGIAC 395

Query: 527 LEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF-------AASD 579
           L+Y       +L+ S S D  I + D      L + L+ H   +  ++F        A D
Sbjct: 396 LQYRD-----RLVVSGSSDNTIRLWDIECGACL-RVLEGHEELVRCIRFDNKRIVSGAYD 449

Query: 580 GQVRM 584
           G++++
Sbjct: 450 GKIKV 454



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 35/115 (30%), Positives = 46/115 (40%), Gaps = 9/115 (7%)

Query: 92  TITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVS 151
           T + L    D + +VTG S     VRVWDV     +  L  H   V  + FS      + 
Sbjct: 267 TGSVLCLQYDERVIVTGSSDS--TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LM 320

Query: 152 VGYQHDMIVNVW--AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA-GNRHIKFW 203
           V    D  + VW  A   +I +    V  R        D  Y V+A G+R IK W
Sbjct: 321 VTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW 375


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 31/105 (29%), Positives = 58/105 (55%), Gaps = 3/105 (2%)

Query: 626 PSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNL 685
           P+  Y A G  D+ +R+++   G   +LF G +G    ++ +   P+G Y+A++  D+ L
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGP---VLSLAFSPNGKYLASAGEDQRL 492

Query: 686 SIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 730
            ++D +SG     + GH++ +T + FS D   + S S D+ + VW
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 59/249 (23%), Positives = 106/249 (42%), Gaps = 26/249 (10%)

Query: 487 VSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDR 546
           +SP+ + LA+G     +++  L+S  + LK E H  ++         + + L      + 
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRS--KKLKSEPHQVDV---------SRIHLACDILEEE 324

Query: 547 LIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQ 606
                +AG E  +   L  H   + + +F A      ++SC  D SI +       D   
Sbjct: 325 DDEDDNAGTEMKI---LRGHCGPVYSTRFLADSSG--LLSCSEDMSIRY------WDLGS 373

Query: 607 FTRTH-HVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLI 665
           FT T  +      ++D+D+ P   Y A G  DR  R+++       +++ G   +     
Sbjct: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDC-- 431

Query: 666 KVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDS 725
            V+  P+  Y+AT  +DK + ++    G  V    GH   V  + FS + K+L S   D 
Sbjct: 432 -VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490

Query: 726 CIFVWRLSS 734
            + +W L+S
Sbjct: 491 RLKLWDLAS 499



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 4/92 (4%)

Query: 72  VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 131
           V L++ ++     +    R  + +LAFSP+GKYL +  +G    +++WD+A  +   EL+
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS--AGEDQRLKLWDLASGTLYKELR 507

Query: 132 EHKYGVACVAFSPSAKYIVSVGYQHDMIVNVW 163
            H   +  + FSP +  I S     D  V VW
Sbjct: 508 GHTDNITSLTFSPDSGLIASASM--DNSVRVW 537



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/113 (24%), Positives = 52/113 (46%), Gaps = 6/113 (5%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           +  + F P+  YL TG +     VR+W   + + V     H+  V  +AFSP+ KY+ S 
Sbjct: 429 VDCVKFHPNSNYLATGSTDK--TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASA 486

Query: 153 GYQHDMIVNVWAWKKNIVVASNK-VSSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
           G   D  + +W      +    +  +  +T+++FS D     +A  +  ++ W
Sbjct: 487 G--EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 56/223 (25%), Positives = 89/223 (39%), Gaps = 54/223 (24%)

Query: 362 VYNDHSIYVWDVRDPKKVGKVYSALYH--SSCVWSVE-VYP------EVKDSNQACLPPS 412
           +Y  H+  VWD+ D       +++  H  ++ +WS +  YP       + D +     P+
Sbjct: 379 LYQGHAYPVWDL-DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPN 437

Query: 413 S--FITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDK 470
           S    T S+D T+RLW+ +                         GN+  L          
Sbjct: 438 SNYLATGSTDKTVRLWSAQQ------------------------GNSVRLFTGH------ 467

Query: 471 ADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYS 530
                   R  + S+  SPNG++LAS      L++ +L S +   ++  H   I  L +S
Sbjct: 468 --------RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519

Query: 531 KPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAV 573
            PD+G  L+ASAS D  + V D    Y      D  SS +  V
Sbjct: 520 -PDSG--LIASASMDNSVRVWDIRNTY-CSAPADGSSSELVGV 558



 Score = 35.4 bits (80), Expect = 0.42
 Identities = 30/112 (26%), Positives = 47/112 (41%), Gaps = 6/112 (5%)

Query: 96  LAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQ 155
           L  SP   Y  +G   H    R+W       +     H   V CV F P++ Y+ +    
Sbjct: 390 LDISPYSLYFASGS--HDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT--GS 445

Query: 156 HDMIVNVW-AWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYL 205
            D  V +W A + N V         V +++FS +  Y  +AG ++ +K W L
Sbjct: 446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 32/144 (22%), Positives = 59/144 (40%), Gaps = 39/144 (27%)

Query: 289 SQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTI 348
           + +Y+  G  D TVRL++                    A    + RLF+G    R P  +
Sbjct: 437 NSNYLATGSTDKTVRLWS--------------------AQQGNSVRLFTG---HRGP-VL 472

Query: 349 ALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALY-HSSCVWSVEVYPEVKDSNQA 407
           +L F P  ++L+    D  + +WD+      G +Y  L  H+  + S+   P+       
Sbjct: 473 SLAFSPNGKYLASAGEDQRLKLWDLAS----GTLYKELRGHTDNITSLTFSPD------- 521

Query: 408 CLPPSSFITCSSDNTIRLWNTESS 431
                   + S DN++R+W+  ++
Sbjct: 522 ---SGLIASASMDNSVRVWDIRNT 542



 Score = 31.6 bits (70), Expect = 6.1
 Identities = 21/93 (22%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 115 AVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNI---VV 171
           ++R WD+   +     Q H Y V  +  SP + Y  S    HD    +W++ +     + 
Sbjct: 365 SIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFAS--GSHDRTARLWSFDRTYPLRIY 422

Query: 172 ASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
           A +     V  V F  + +Y  T   ++ ++ W
Sbjct: 423 AGHLAD--VDCVKFHPNSNYLATGSTDKTVRLW 453


>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
          Length = 919

 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 72/286 (25%), Positives = 115/286 (40%), Gaps = 32/286 (11%)

Query: 474 SLLDPRVGIRSVCVSPNGQHLASGDRMGTLRV-----------HEL--QSLSEMLKVEAH 520
           ++L+    +R+V   P G   A G    TLRV           HE   Q +    + + H
Sbjct: 601 NILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHH 660

Query: 521 DSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD----EHSSSITAVKF- 575
              I C+ +S      +LLA+ S D+ + VL    E       D     H  +I  + F 
Sbjct: 661 KGSIYCVAWSPCG---QLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFM 717

Query: 576 -AASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTH--HVVRKTTLYDMDVEPSWKYTA 632
                G   +IS GA     + T  + G G+     H  H++    LY       W   A
Sbjct: 718 EGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL---ALYTWS---GWMI-A 770

Query: 633 IGCQDRNIRIFNISSGKQKKLFKGS-QGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS 691
            G QD+ +R +++      ++   +  G    +  V  DPSG  +AT   D +  ++D  
Sbjct: 771 SGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIR 830

Query: 692 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMT 737
            G  V +   HS  V  ++FS    +L++ S D  I V  L  ++T
Sbjct: 831 GGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLT 876



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 26/117 (22%), Positives = 50/117 (42%), Gaps = 10/117 (8%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           + ++A  P G+ L TG+     +  ++D+     V     H   V  V FSP A Y+++ 
Sbjct: 803 VASVAVDPSGRLLATGQEDS--SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTG 860

Query: 153 GYQHDMIVNVWAWKKN------IVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFW 203
            Y  DM + V   + +      I+V        +     ++D S+  ++ +R +  W
Sbjct: 861 SY--DMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 915


>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
          Length = 927

 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 72/286 (25%), Positives = 115/286 (40%), Gaps = 32/286 (11%)

Query: 474 SLLDPRVGIRSVCVSPNGQHLASGDRMGTLRV-----------HEL--QSLSEMLKVEAH 520
           ++L+    +R+V   P G   A G    TLRV           HE   Q +    + + H
Sbjct: 609 NILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHH 668

Query: 521 DSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD----EHSSSITAVKF- 575
              I C+ +S      +LLA+ S D+ + VL    E       D     H  +I  + F 
Sbjct: 669 KGSIYCVAWSPCG---QLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFM 725

Query: 576 -AASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTH--HVVRKTTLYDMDVEPSWKYTA 632
                G   +IS GA     + T  + G G+     H  H++    LY       W   A
Sbjct: 726 EGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL---ALYTWS---GWMI-A 778

Query: 633 IGCQDRNIRIFNISSGKQKKLFKGS-QGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS 691
            G QD+ +R +++      ++   +  G    +  V  DPSG  +AT   D +  ++D  
Sbjct: 779 SGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIR 838

Query: 692 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMT 737
            G  V +   HS  V  ++FS    +L++ S D  I V  L  ++T
Sbjct: 839 GGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLT 884



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 26/117 (22%), Positives = 50/117 (42%), Gaps = 10/117 (8%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           + ++A  P G+ L TG+     +  ++D+     V     H   V  V FSP A Y+++ 
Sbjct: 811 VASVAVDPSGRLLATGQEDS--SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTG 868

Query: 153 GYQHDMIVNVWAWKKN------IVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFW 203
            Y  DM + V   + +      I+V        +     ++D S+  ++ +R +  W
Sbjct: 869 SY--DMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923


>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
          Length = 920

 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 72/286 (25%), Positives = 115/286 (40%), Gaps = 32/286 (11%)

Query: 474 SLLDPRVGIRSVCVSPNGQHLASGDRMGTLRV-----------HEL--QSLSEMLKVEAH 520
           ++L+    +R+V   P G   A G    TLRV           HE   Q +    + + H
Sbjct: 602 NILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHH 661

Query: 521 DSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLD----EHSSSITAVKF- 575
              I C+ +S      +LLA+ S D+ + VL    E       D     H  +I  + F 
Sbjct: 662 KGSIYCVAWSPCG---QLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFM 718

Query: 576 -AASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTH--HVVRKTTLYDMDVEPSWKYTA 632
                G   +IS GA     + T  + G G+     H  H++    LY       W   A
Sbjct: 719 EGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL---ALYTWS---GWMI-A 771

Query: 633 IGCQDRNIRIFNISSGKQKKLFKGS-QGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFS 691
            G QD+ +R +++      ++   +  G    +  V  DPSG  +AT   D +  ++D  
Sbjct: 772 SGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIR 831

Query: 692 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMT 737
            G  V +   HS  V  ++FS    +L++ S D  I V  L  ++T
Sbjct: 832 GGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLT 877



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 26/117 (22%), Positives = 50/117 (42%), Gaps = 10/117 (8%)

Query: 93  ITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSV 152
           + ++A  P G+ L TG+     +  ++D+     V     H   V  V FSP A Y+++ 
Sbjct: 804 VASVAVDPSGRLLATGQEDS--SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTG 861

Query: 153 GYQHDMIVNVWAWKKN------IVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFW 203
            Y  DM + V   + +      I+V        +     ++D S+  ++ +R +  W
Sbjct: 862 SY--DMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 76/368 (20%), Positives = 143/368 (38%), Gaps = 62/368 (16%)

Query: 371 WDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTES 430
           W  R P+K    Y+   H S V  V  +P            S  ++ S D TI++W+ E+
Sbjct: 94  WIPRPPEK----YALSGHRSPVTRVIFHPVF----------SVMVSASEDATIKVWDYET 139

Query: 431 SGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELP--------GGDKADASLLDPRVGI 482
            G    TL  +   +D ++ I  D + + L               G +   ++      +
Sbjct: 140 -GDFERTLKGH---TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195

Query: 483 RSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASA 542
            SV + PNG H+ S  R  T+++ E+Q+   +     H   +  +   +P+    L+AS 
Sbjct: 196 SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV---RPNQDGTLIASC 252

Query: 543 SRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSG 602
           S D+ + V     +   +  L EH   +  + +A       +      ++      +KSG
Sbjct: 253 SNDQTVRVWVVATK-ECKAELREHEHVVECISWAPESSYSSISEATGSET------KKSG 305

Query: 603 DGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDG 662
               F  +                       G +D+ I+++++S+G          G D 
Sbjct: 306 KPGPFLLS-----------------------GSRDKTIKMWDVSTGM---CLMTLVGHDN 339

Query: 663 TLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVS 722
            +  V     G +I +   DK L ++D+ +  C+ T+  H   VT + F     ++++ S
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGS 399

Query: 723 GDSCIFVW 730
            D  + VW
Sbjct: 400 VDQTVKVW 407



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 3/109 (2%)

Query: 626 PSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNL 685
           P +       +D  I++++  +G  ++  KG      ++  +  D SG  +A+  +D  +
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKG---HTDSVQDISFDHSGKLLASCSADMTI 174

Query: 686 SIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 734
            ++DF   EC+ TM GH   V+ +    +  H++S S D  I +W + +
Sbjct: 175 KLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 55/231 (23%), Positives = 97/231 (41%), Gaps = 25/231 (10%)

Query: 563 LDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDM 622
           L  H S +T V F        M+S   D +I     + +GD  +  + H      ++ D+
Sbjct: 104 LSGHRSPVTRVIFHPVFSV--MVSASEDATIKVWDYE-TGDFERTLKGH----TDSVQDI 156

Query: 623 DVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSD 682
             + S K  A    D  I++++    +     +   G D  +  V   P+G +I ++  D
Sbjct: 157 SFDHSGKLLASCSADMTIKLWDFQGFE---CIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213

Query: 683 KNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQ 742
           K + +++  +G CV T  GH E V  ++ + D   + S S D  + VW       ++ ++
Sbjct: 214 KTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW------VVATKE 267

Query: 743 RLAELRQRQR------GGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDS 787
             AELR+ +          +   SS   A+G    ++     PGP L S S
Sbjct: 268 CKAELREHEHVVECISWAPESSYSSISEATGSETKKSG---KPGPFLLSGS 315



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 6/104 (5%)

Query: 102 GKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVN 161
           G +L++G       +++WDV+    +  L  H   V  V F    K+I+S     D  + 
Sbjct: 308 GPFLLSGSRDK--TIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCA--DDKTLR 363

Query: 162 VWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFVTAG-NRHIKFW 203
           VW +K K  +   N     VT++ F +   Y VT   ++ +K W
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 15/33 (45%), Positives = 23/33 (69%)

Query: 116 VRVWDVAEHSQVAELQEHKYGVACVAFSPSAKY 148
           VRVW VA     AEL+EH++ V C++++P + Y
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSY 290



 Score = 31.2 bits (69), Expect = 8.0
 Identities = 17/78 (21%), Positives = 34/78 (43%), Gaps = 4/78 (5%)

Query: 86  LNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPS 145
           L     ++  ++F   GK L +  +     +++WD      +  +  H + V+ VA  P+
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADM--TIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203

Query: 146 AKYIVSVGYQHDMIVNVW 163
             +IVS     D  + +W
Sbjct: 204 GDHIVSA--SRDKTIKMW 219


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,462,716
Number of Sequences: 37866
Number of extensions: 3772149
Number of successful extensions: 23203
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 929
Number of HSP's that attempted gapping in prelim test: 17393
Number of HSP's gapped (non-prelim): 5373
length of query: 1514
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1399
effective length of database: 13,892,928
effective search space: 19436206272
effective search space used: 19436206272
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.