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Search of human proteins with 186928844
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
(1444 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 2907 0.0
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 358 2e-98
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 358 2e-98
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 354 3e-97
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 354 3e-97
gi|23510413 sorting nexin 26 [Homo sapiens] 302 2e-81
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 125 3e-28
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 125 3e-28
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 118 5e-26
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 118 5e-26
gi|188497642 ARHGAP15 [Homo sapiens] 113 1e-24
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 110 1e-23
gi|229094128 active breakpoint cluster region-related protein i... 107 8e-23
gi|38679957 active breakpoint cluster region-related protein is... 107 8e-23
gi|38679954 active breakpoint cluster region-related protein is... 107 8e-23
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 106 1e-22
gi|156119615 myosin IXA [Homo sapiens] 106 1e-22
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 106 1e-22
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 106 1e-22
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 105 3e-22
gi|54860079 nadrin isoform 1 [Homo sapiens] 102 3e-21
gi|54860105 nadrin isoform 2 [Homo sapiens] 102 3e-21
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 102 3e-21
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 102 3e-21
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 100 1e-20
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 100 1e-20
gi|208022687 GTPase regulator associated with the focal adhesion... 100 2e-20
gi|7662208 GTPase regulator associated with the focal adhesion k... 100 2e-20
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 98 5e-20
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 97 9e-20
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 2907 bits (7535), Expect = 0.0
Identities = 1444/1444 (100%), Positives = 1444/1444 (100%)
Query: 1 MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGV 60
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGV
Sbjct: 1 MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGV 60
Query: 61 TSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS 120
TSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS
Sbjct: 61 TSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS 120
Query: 121 HCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
HCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR
Sbjct: 121 HCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
Query: 181 SKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPA 240
SKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPA
Sbjct: 181 SKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPA 240
Query: 241 LSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSK 300
LSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSK
Sbjct: 241 LSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSK 300
Query: 301 SKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKET 360
SKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKET
Sbjct: 301 SKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKET 360
Query: 361 KGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHL 420
KGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHL
Sbjct: 361 KGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHL 420
Query: 421 QGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQ 480
QGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQ
Sbjct: 421 QGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQ 480
Query: 481 RKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEK 540
RKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEK
Sbjct: 481 RKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEK 540
Query: 541 PLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLN 600
PLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLN
Sbjct: 541 PLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLN 600
Query: 601 ELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQEL 660
ELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQEL
Sbjct: 601 ELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQEL 660
Query: 661 KIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTR 720
KIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTR
Sbjct: 661 KIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTR 720
Query: 721 DPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPP 780
DPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPP
Sbjct: 721 DPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPP 780
Query: 781 LPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEAT 840
LPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEAT
Sbjct: 781 LPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEAT 840
Query: 841 PRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQH 900
PRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQH
Sbjct: 841 PRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQH 900
Query: 901 GLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPT 960
GLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPT
Sbjct: 901 GLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPT 960
Query: 961 VKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPP 1020
VKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPP
Sbjct: 961 VKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPP 1020
Query: 1021 NQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTS 1080
NQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTS
Sbjct: 1021 NQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTS 1080
Query: 1081 PGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDP 1140
PGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDP
Sbjct: 1081 PGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDP 1140
Query: 1141 KVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAV 1200
KVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAV
Sbjct: 1141 KVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAV 1200
Query: 1201 PVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKE 1260
PVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKE
Sbjct: 1201 PVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKE 1260
Query: 1261 EKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDN 1320
EKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDN
Sbjct: 1261 EKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDN 1320
Query: 1321 LLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPT 1380
LLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPT
Sbjct: 1321 LLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPT 1380
Query: 1381 QTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSG 1440
QTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSG
Sbjct: 1381 QTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSG 1440
Query: 1441 RQIE 1444
RQIE
Sbjct: 1441 RQIE 1444
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 358 bits (919), Expect = 2e-98
Identities = 195/359 (54%), Positives = 249/359 (69%), Gaps = 20/359 (5%)
Query: 6 AKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSN 63
++QK K+KG+A FGCDL E+L+ SGQ+VP VLKSCAEF+E +G+VDGIYRLSGV+SN
Sbjct: 3 SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
Query: 64 IQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP 123
IQ+LRQEF S++ PDL R+VYLQDIHCV SLCK YFRELP+PLLTY LY+KF EAV
Sbjct: 63 IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
Query: 124 EEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183
E +L +I V++ELP +YRTLE+L+RHL H+ASFS++TNMHARNLA+VWAPNLLRSK+
Sbjct: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Query: 184 IEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSL 243
IEA+G NG AAF+ VRVQ +V+EFIL HVDQ+F A L E +SL S
Sbjct: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRAS- 238
Query: 244 PMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKK 303
S E+ R L + P+ + + PP +HT++E+ ++KRK S K +K
Sbjct: 239 ----GSPEDLMPRPLPYHLPSILQAGDG------PPQMRPYHTIIEIAEHKRKGSLKVRK 288
Query: 304 WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKG 362
W+SIFNLGRSG ++K KL R + K T+RPAKSMDSL + E +G
Sbjct: 289 WRSIFNLGRSGHETKRKLPRG----AEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEG 343
Score = 32.3 bits (72), Expect = 3.4
Identities = 13/31 (41%), Positives = 23/31 (74%)
Query: 1189 SFMVKMCQARAVPVIPPKIQYTQIPQPLPSQ 1219
S +V++ Q R+VPV+PPK Q+ ++P + S+
Sbjct: 715 STLVQVQQVRSVPVVPPKPQFAKMPSAMCSK 745
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 358 bits (919), Expect = 2e-98
Identities = 195/359 (54%), Positives = 249/359 (69%), Gaps = 20/359 (5%)
Query: 6 AKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSN 63
++QK K+KG+A FGCDL E+L+ SGQ+VP VLKSCAEF+E +G+VDGIYRLSGV+SN
Sbjct: 3 SRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVSSN 62
Query: 64 IQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP 123
IQ+LRQEF S++ PDL R+VYLQDIHCV SLCK YFRELP+PLLTY LY+KF EAV
Sbjct: 63 IQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQL 122
Query: 124 EEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKE 183
E +L +I V++ELP +YRTLE+L+RHL H+ASFS++TNMHARNLA+VWAPNLLRSK+
Sbjct: 123 EPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKD 182
Query: 184 IEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPALSL 243
IEA+G NG AAF+ VRVQ +V+EFIL HVDQ+F A L E +SL S
Sbjct: 183 IEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAA---LSGGEVESGWRSLPGTRAS- 238
Query: 244 PMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKK 303
S E+ R L + P+ + + PP +HT++E+ ++KRK S K +K
Sbjct: 239 ----GSPEDLMPRPLPYHLPSILQAGDG------PPQMRPYHTIIEIAEHKRKGSLKVRK 288
Query: 304 WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKETKG 362
W+SIFNLGRSG ++K KL R + K T+RPAKSMDSL + E +G
Sbjct: 289 WRSIFNLGRSGHETKRKLPRG----AEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEG 343
Score = 32.3 bits (72), Expect = 3.4
Identities = 13/31 (41%), Positives = 23/31 (74%)
Query: 1189 SFMVKMCQARAVPVIPPKIQYTQIPQPLPSQ 1219
S +V++ Q R+VPV+PPK Q+ ++P + S+
Sbjct: 926 STLVQVQQVRSVPVVPPKPQFAKMPSAMCSK 956
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 354 bits (909), Expect = 3e-97
Identities = 290/839 (34%), Positives = 419/839 (49%), Gaps = 97/839 (11%)
Query: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLS 58
MK++ KQKLK++G FGCDL E+L +SG +VP VL+SC FIE +GIVDGIYRLS
Sbjct: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
Query: 59 GVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEA 118
GV SNIQRLR EF S+ PDLT+E Y+QDIH VGSLCKLYFRELPNPLLTY+LYEKF++A
Sbjct: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
Query: 119 VSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNL 178
VS +E +L +I +VIQ+LPP HYRTLE+L+RHL+ +A + S TNMHA+NLA+VWAPNL
Sbjct: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
Query: 179 LRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDE---NRPIMKS 235
LRSK+IE+ +G AAF+ VR+Q VV+EFILNHVD +F+ +++ +RP KS
Sbjct: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRP--KS 587
Query: 236 LTLPALSLPMKLVSLEEAQARSLA-TNHPARKERRENSLPEIVPPMGTLFHTVLELPDNK 294
L + + S KL++LEEAQAR+ A N P E + + E + FHT++E P +
Sbjct: 588 LLVSSPS--TKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLER 645
Query: 295 RKLSSKSKK-----WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVE----KATIRPAK 345
++ +K KK W+S FNLG+S S SK KL RN S + ++++ + T+R AK
Sbjct: 646 KRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAK 705
Query: 346 SMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSC---DLTKQEGEWGQEG 402
S +SL S+ ++K R + + A+ + G+ C D + E +EG
Sbjct: 706 SEESLTSLHAVDGDSKLFRPRRPRSSSDALSAS-FNGEMLGNRCNSYDNLPHDNESEEEG 764
Query: 403 ---------MPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGM 453
P AE DV + A P + P + E ++ L
Sbjct: 765 GLLHIPALMSPHSAE---DVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDS 821
Query: 454 FYTSNDSPS---KSVFT-SSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPC 509
S D PS K T SS Q S + + E + L +S +S P
Sbjct: 822 PGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPS 881
Query: 510 RTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGT 569
K + + S P+ + L +++ + S+ + + V E GT
Sbjct: 882 SFTEKVVYAFS---------------PKIGRKL-SKSPSMSISEPISVTLPPRVSEVIGT 925
Query: 570 VECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQES 629
V S +Q + +K E +++ ++ K E V +E E S +Q
Sbjct: 926 V--SNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYE------SEVQPL 977
Query: 630 PRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESS 689
+ AE V L ++ ++++ + K + S + + A+ P Q + S
Sbjct: 978 DQVAAEEVELPGKEDQSVSSS--------QSKAVASGQTQTG----AVTHDPPQDSVPVS 1025
Query: 690 LGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQ-STQ-----GASTAASREKPE--- 740
IP PP P V+ L + + A Q STQ G S A +
Sbjct: 1026 SVSLIPPPPP--------PKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAV 1077
Query: 741 --PEQGLHPDLASLAPLEIVPFEKASP--QATVEVGGPGNLSPPLPPAPPPPTPLEEST 795
E L +++A L+ F+ P Q ++ PGN PLP P +T
Sbjct: 1078 ATTEDNLSSSYSAVA-LDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNT 1135
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 354 bits (909), Expect = 3e-97
Identities = 290/839 (34%), Positives = 419/839 (49%), Gaps = 97/839 (11%)
Query: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLS 58
MK++ KQKLK++G FGCDL E+L +SG +VP VL+SC FIE +GIVDGIYRLS
Sbjct: 1 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 60
Query: 59 GVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEA 118
GV SNIQRLR EF S+ PDLT+E Y+QDIH VGSLCKLYFRELPNPLLTY+LYEKF++A
Sbjct: 61 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 120
Query: 119 VSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNL 178
VS +E +L +I +VIQ+LPP HYRTLE+L+RHL+ +A + S TNMHA+NLA+VWAPNL
Sbjct: 121 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180
Query: 179 LRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDE---NRPIMKS 235
LRSK+IE+ +G AAF+ VR+Q VV+EFILNHVD +F+ +++ +RP KS
Sbjct: 181 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRP--KS 238
Query: 236 LTLPALSLPMKLVSLEEAQARSLA-TNHPARKERRENSLPEIVPPMGTLFHTVLELPDNK 294
L + + S KL++LEEAQAR+ A N P E + + E + FHT++E P +
Sbjct: 239 LLVSSPS--TKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLER 296
Query: 295 RKLSSKSKK-----WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVE----KATIRPAK 345
++ +K KK W+S FNLG+S S SK KL RN S + ++++ + T+R AK
Sbjct: 297 KRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAK 356
Query: 346 SMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSC---DLTKQEGEWGQEG 402
S +SL S+ ++K R + + A+ + G+ C D + E +EG
Sbjct: 357 SEESLTSLHAVDGDSKLFRPRRPRSSSDALSAS-FNGEMLGNRCNSYDNLPHDNESEEEG 415
Query: 403 ---------MPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGM 453
P AE DV + A P + P + E ++ L
Sbjct: 416 GLLHIPALMSPHSAE---DVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDS 472
Query: 454 FYTSNDSPS---KSVFT-SSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPC 509
S D PS K T SS Q S + + E + L +S +S P
Sbjct: 473 PGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPS 532
Query: 510 RTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGT 569
K + + S P+ + L +++ + S+ + + V E GT
Sbjct: 533 SFTEKVVYAFS---------------PKIGRKL-SKSPSMSISEPISVTLPPRVSEVIGT 576
Query: 570 VECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQES 629
V S +Q + +K E +++ ++ K E V +E E S +Q
Sbjct: 577 V--SNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYE------SEVQPL 628
Query: 630 PRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESS 689
+ AE V L ++ ++++ + K + S + + A+ P Q + S
Sbjct: 629 DQVAAEEVELPGKEDQSVSSS--------QSKAVASGQTQTG----AVTHDPPQDSVPVS 676
Query: 690 LGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQ-STQ-----GASTAASREKPE--- 740
IP PP P V+ L + + A Q STQ G S A +
Sbjct: 677 SVSLIPPPPP--------PKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAV 728
Query: 741 --PEQGLHPDLASLAPLEIVPFEKASP--QATVEVGGPGNLSPPLPPAPPPPTPLEEST 795
E L +++A L+ F+ P Q ++ PGN PLP P +T
Sbjct: 729 ATTEDNLSSSYSAVA-LDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNT 786
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 302 bits (773), Expect = 2e-81
Identities = 177/358 (49%), Positives = 233/358 (65%), Gaps = 14/358 (3%)
Query: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLS 58
M+++ ++Q+L+++G FGCDL E+L +SGQDVP VL+ C+EFIE HG+VDGIYRLS
Sbjct: 293 MRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLS 352
Query: 59 GVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEA 118
GV+SNIQRLR EF S++ P+L+ +LQDIH V SLCKLYFRELPNPLLTY+LY KF+EA
Sbjct: 353 GVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEA 412
Query: 119 VSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNL 178
+S EE +L R+ +VIQ+LPP HYRTLEYL+RHLA +A S+ T+MHARNLA+VWAPNL
Sbjct: 413 MSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNL 472
Query: 179 LRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTL 238
LRS E+E+ G G AAF VRVQ VV+EF+L HVD +F++ + + R ++
Sbjct: 473 LRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKS 532
Query: 239 PALSLP-MKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKL 297
A S P +L++LEEAQAR+ E + P+ P E + +RK
Sbjct: 533 LAGSCPSTRLLTLEEAQART----QGRLGTPTEPTTPK--APASPAERRKGERGEKQRKP 586
Query: 298 SSKSKKWKSIFNLGRSGSDSKSK-LSRNGSVFVRGQRLS--VEKATIRPAKSMDSLCS 352
S WK+ F LGR S + K L G Q + T+R AKS +SL S
Sbjct: 587 GGSS--WKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSS 642
Score = 36.2 bits (82), Expect = 0.23
Identities = 49/172 (28%), Positives = 70/172 (40%), Gaps = 40/172 (23%)
Query: 681 PIQPILESSLGPFIPSEPPGSL--PCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREK 738
P+ P +ES L P PP SL P G+ P P P N + A A R +
Sbjct: 705 PLGPDMESPLPP-----PPLSLLRPGGAPPPP-----------PKNPARLMALALAERAQ 748
Query: 739 PEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGG-----------PGNLSPP--LPPAP 785
EQ + P PF ++ ++EVGG P +L+ P P P
Sbjct: 749 QVAEQQSQQECGGTPPASQSPFHRS---LSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGP 805
Query: 786 PPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYID-QLKS----QDSPEISS 832
PP P ++S LL P S R LR + QL++ +D+PE ++
Sbjct: 806 PPYLPRQQSDGSLLRSQRP-MGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAA 856
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 125 bits (314), Expect = 3e-28
Identities = 69/206 (33%), Positives = 116/206 (56%), Gaps = 8/206 (3%)
Query: 13 KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF 71
K + CDLT +++ P V+ C IE+ G+ +G+YR+SG + I+ ++ F
Sbjct: 260 KHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF 319
Query: 72 GSD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLAR 130
D + D++ +Y +DI+ + KLYFR+LP PL+TY+ Y KF E+ + QL
Sbjct: 320 DRDGEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLET 378
Query: 131 IQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCN 190
+ ++ LPP+H TL YL+ HL + + M+A NL +V+ P L+RS E++A
Sbjct: 379 LHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM--- 435
Query: 191 GDAAFLAVRVQQVVIEFILNHVDQIF 216
AA +R Q++V+E ++ + D +F
Sbjct: 436 --AALNDIRYQRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 125 bits (314), Expect = 3e-28
Identities = 69/206 (33%), Positives = 116/206 (56%), Gaps = 8/206 (3%)
Query: 13 KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF 71
K + CDLT +++ P V+ C IE+ G+ +G+YR+SG + I+ ++ F
Sbjct: 234 KHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF 293
Query: 72 GSD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLAR 130
D + D++ +Y +DI+ + KLYFR+LP PL+TY+ Y KF E+ + QL
Sbjct: 294 DRDGEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLET 352
Query: 131 IQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCN 190
+ ++ LPP+H TL YL+ HL + + M+A NL +V+ P L+RS E++A
Sbjct: 353 LHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM--- 409
Query: 191 GDAAFLAVRVQQVVIEFILNHVDQIF 216
AA +R Q++V+E ++ + D +F
Sbjct: 410 --AALNDIRYQRLVVELLIKNEDILF 433
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 118 bits (295), Expect = 5e-26
Identities = 66/206 (32%), Positives = 110/206 (53%), Gaps = 8/206 (3%)
Query: 13 KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEF 71
K + CDLT +++ P V+ C IE G+ +G+YR+SG T +I+ ++ F
Sbjct: 269 KRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAF 328
Query: 72 GSD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLAR 130
D + D++ VY DI+ + KLYFR+LP P++TY+ Y KF +A + +L
Sbjct: 329 DRDGEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEA 387
Query: 131 IQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCN 190
+ V+ LPP+HY TL YL+ HL + M+A NL +V+ P L+R E
Sbjct: 388 VHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTL 447
Query: 191 GDAAFLAVRVQQVVIEFILNHVDQIF 216
D +R Q+++++ ++ + D +F
Sbjct: 448 HD-----MRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 118 bits (295), Expect = 5e-26
Identities = 66/206 (32%), Positives = 110/206 (53%), Gaps = 8/206 (3%)
Query: 13 KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEF 71
K + CDLT +++ P V+ C IE G+ +G+YR+SG T +I+ ++ F
Sbjct: 133 KRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAF 192
Query: 72 GSD-QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLAR 130
D + D++ VY DI+ + KLYFR+LP P++TY+ Y KF +A + +L
Sbjct: 193 DRDGEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEA 251
Query: 131 IQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCN 190
+ V+ LPP+HY TL YL+ HL + M+A NL +V+ P L+R E
Sbjct: 252 VHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTL 311
Query: 191 GDAAFLAVRVQQVVIEFILNHVDQIF 216
D +R Q+++++ ++ + D +F
Sbjct: 312 HD-----MRYQKLIVQILIENEDVLF 332
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 113 bits (283), Expect = 1e-24
Identities = 68/201 (33%), Positives = 109/201 (54%), Gaps = 8/201 (3%)
Query: 19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP 77
FG L + E VP+ +K C E +E G+ VDGIYR+SG + IQ+LR ++
Sbjct: 279 FGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKL 338
Query: 78 DLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQE 137
+L + +DIH V K++FRELP PL Y +E+F EA+ ++ +++++Q+
Sbjct: 339 NLDDSQW-EDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQK 397
Query: 138 LPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLA 197
LPP + T++ L HL I + +SK M ++L +V+ P LLR A G+ A
Sbjct: 398 LPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR-----AENETGNMAIHM 452
Query: 198 VRVQQVVIEFILNHVDQIFNN 218
V Q + E +L+ +IF +
Sbjct: 453 V-YQNQIAELMLSEYSKIFGS 472
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 110 bits (275), Expect = 1e-23
Identities = 68/212 (32%), Positives = 113/212 (53%), Gaps = 11/212 (5%)
Query: 8 QKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNI 64
Q ++ KG FG +L + VP +K C E +E HG+ +DGIYR+SG + I
Sbjct: 641 QAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVI 700
Query: 65 QRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPE 124
Q+LR D+ DL + +DIH + K++FRELP PL T+ + F A+ P
Sbjct: 701 QKLRFAVNHDEKLDLNDSKW-EDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPR 759
Query: 125 EGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEI 184
+ ++A ++++I++LP + T++ L RHL + K M +++A+V+ P LL+ ++
Sbjct: 760 Q-RVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKE 818
Query: 185 EATGCNGDAAFLAVRVQQVVIEFILNHVDQIF 216
G+ A V Q ++E IL + IF
Sbjct: 819 -----TGNIAVHTV-YQNQIVELILLELSSIF 844
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 107 bits (267), Expect = 8e-23
Identities = 71/218 (32%), Positives = 107/218 (49%), Gaps = 8/218 (3%)
Query: 1 MKNKGAKQKLKR---KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYR 56
MK LKR K FG ++ + VPY+++ C E +E GI + GIYR
Sbjct: 578 MKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYR 637
Query: 57 LSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFT 116
+SGV ++IQ L+ F ++ D+ + DI+ + KLYFRELP PLLT LY F
Sbjct: 638 ISGVATDIQALKAVFDANN-KDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFM 696
Query: 117 EAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
E ++ + + ++++ LP + T +L+ HL +A M NLA V+ P
Sbjct: 697 EGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGP 756
Query: 177 NLLRSKEIEATGCNGDAAFL---AVRVQQVVIEFILNH 211
LLR E+E+ AA + V Q V+ + L H
Sbjct: 757 TLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 794
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 107 bits (267), Expect = 8e-23
Identities = 71/218 (32%), Positives = 107/218 (49%), Gaps = 8/218 (3%)
Query: 1 MKNKGAKQKLKR---KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYR 56
MK LKR K FG ++ + VPY+++ C E +E GI + GIYR
Sbjct: 624 MKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYR 683
Query: 57 LSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFT 116
+SGV ++IQ L+ F ++ D+ + DI+ + KLYFRELP PLLT LY F
Sbjct: 684 ISGVATDIQALKAVFDANN-KDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFM 742
Query: 117 EAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
E ++ + + ++++ LP + T +L+ HL +A M NLA V+ P
Sbjct: 743 EGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGP 802
Query: 177 NLLRSKEIEATGCNGDAAFL---AVRVQQVVIEFILNH 211
LLR E+E+ AA + V Q V+ + L H
Sbjct: 803 TLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 840
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 107 bits (267), Expect = 8e-23
Identities = 71/218 (32%), Positives = 107/218 (49%), Gaps = 8/218 (3%)
Query: 1 MKNKGAKQKLKR---KGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYR 56
MK LKR K FG ++ + VPY+++ C E +E GI + GIYR
Sbjct: 587 MKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYR 646
Query: 57 LSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFT 116
+SGV ++IQ L+ F ++ D+ + DI+ + KLYFRELP PLLT LY F
Sbjct: 647 ISGVATDIQALKAVFDANN-KDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFM 705
Query: 117 EAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
E ++ + + ++++ LP + T +L+ HL +A M NLA V+ P
Sbjct: 706 EGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGP 765
Query: 177 NLLRSKEIEATGCNGDAAFL---AVRVQQVVIEFILNH 211
LLR E+E+ AA + V Q V+ + L H
Sbjct: 766 TLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH 803
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 106 bits (265), Expect = 1e-22
Identities = 66/212 (31%), Positives = 110/212 (51%), Gaps = 7/212 (3%)
Query: 9 KLKRKGAASAFGCDLTEYLESS-GQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQR 66
K +K A AFG L E ++ Q VP ++ +C +E G+ GIYR+ G + +
Sbjct: 799 KKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSS 858
Query: 67 LRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEG 126
L+++ ++ QD++ + SL K +FR+LP PL T + Y F EA
Sbjct: 859 LQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARE 918
Query: 127 QLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEA 186
++ ++ +I++LP +Y TL++L+ HL IA S K M RNLALV+ P L+R+ E
Sbjct: 919 RMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNM 978
Query: 187 TGCNGDAAFLAVRVQQVVIEFILNHVDQIFNN 218
T + R + ++E ++ H D F++
Sbjct: 979 TDM---VTHMPDRYK--IVETLIQHSDWFFSD 1005
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 106 bits (265), Expect = 1e-22
Identities = 66/165 (40%), Positives = 94/165 (56%), Gaps = 9/165 (5%)
Query: 19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP 77
FG +L+ L S + VP V++ +IE HG+ +GIYR SG T+ I+ LRQ +D
Sbjct: 2061 FGVELSR-LTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD--- 2116
Query: 78 DLTREVYLQD--IHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVI 135
V L D IH + S+ K + R+LPNPL+T+ELYE+F A+ + + + +VI
Sbjct: 2117 --AESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVI 2174
Query: 136 QELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
+L +H TLE LI HL IA M A LA+V+AP +LR
Sbjct: 2175 DQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILR 2219
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 106 bits (265), Expect = 1e-22
Identities = 65/219 (29%), Positives = 109/219 (49%), Gaps = 10/219 (4%)
Query: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRL 57
++ + Q L+ KG FGC L E VP ++ C +E G+ +DG+YR+
Sbjct: 307 LQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRI 366
Query: 58 SGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTE 117
SG + IQ+LR + D+ DL + +D+H + KL+FRELP PL + + +F
Sbjct: 367 SGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFRQFIA 425
Query: 118 AVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
A+ + + ++++++ LP ++ TL L +HL + + M +++A+V+ P
Sbjct: 426 AIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPT 485
Query: 178 LLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIF 216
LLR E+E T F Q V+E IL IF
Sbjct: 486 LLR-PEVEETSMPMTMVF-----QNQVVELILQQCADIF 518
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 106 bits (265), Expect = 1e-22
Identities = 65/219 (29%), Positives = 109/219 (49%), Gaps = 10/219 (4%)
Query: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRL 57
++ + Q L+ KG FGC L E VP ++ C +E G+ +DG+YR+
Sbjct: 334 LQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRI 393
Query: 58 SGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTE 117
SG + IQ+LR + D+ DL + +D+H + KL+FRELP PL + + +F
Sbjct: 394 SGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFRQFIA 452
Query: 118 AVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
A+ + + ++++++ LP ++ TL L +HL + + M +++A+V+ P
Sbjct: 453 AIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPT 512
Query: 178 LLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIF 216
LLR E+E T F Q V+E IL IF
Sbjct: 513 LLR-PEVEETSMPMTMVF-----QNQVVELILQQCADIF 545
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 105 bits (262), Expect = 3e-22
Identities = 77/273 (28%), Positives = 126/273 (46%), Gaps = 24/273 (8%)
Query: 19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQCP 77
+G L +L+ G+++ +++C + + G+ + G++RL+ S ++RL+Q SD
Sbjct: 274 YGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPH- 332
Query: 78 DLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQE 137
+ E + D H V K Y RELP PL+T++LY+ + A S +L +Q V
Sbjct: 333 --SLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSR 390
Query: 138 LPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLA 197
LPP + L YL++ LA +A M N+A+V PNLL E E DAA ++
Sbjct: 391 LPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVS 450
Query: 198 VRVQQVVIEFILNHVDQIFNNGAPGSLE------------NDENRPIMKSLTLPALSLPM 245
V+E ++ D +F PG + D + S LP+ ++P
Sbjct: 451 SIQVVGVVEALIQSADTLF----PGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPT 506
Query: 246 KLV----SLEEAQARSLATNHPARKERRENSLP 274
+ A A + A A KER E+ +P
Sbjct: 507 PATTPAPAPAPAPAPAPALASAATKERTESEVP 539
Score = 38.9 bits (89), Expect = 0.036
Identities = 43/144 (29%), Positives = 56/144 (38%), Gaps = 24/144 (16%)
Query: 663 IESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGS------------LPCGSFPAP 710
+E + P PA T P + S P P PPGS L S AP
Sbjct: 558 VEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAP 617
Query: 711 -VSTPLEVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIV-PFEKASPQAT 768
V PL PA + ++ + + S P P AS +P+ + P + AT
Sbjct: 618 TVPPPLPPTPPQPARRQSRRSPASPSPASPGP--------ASPSPVSLSNPAQVDLGAAT 669
Query: 769 VEVGGPGNLS-PPLPPA-PPPPTP 790
E G P +S P PPA PP P P
Sbjct: 670 AEGGAPEAISGVPTPPAIPPQPRP 693
Score = 31.2 bits (69), Expect = 7.6
Identities = 31/121 (25%), Positives = 42/121 (34%), Gaps = 16/121 (13%)
Query: 673 PPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRD-----PANQST 727
P PAL ++ + ES + P P S P + P+E R PA +
Sbjct: 521 PAPALASAATKERTESEVPP-----RPASPKVTRSPPETAAPVEDMARRTKRPAPARPTM 575
Query: 728 QGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPP 787
+ SR P P L P S + +P + PPLPP PP
Sbjct: 576 PPPQVSGSRSSP-PAPPLPPGSGSPGTPQALPRRLVGSSLRAPT-----VPPPLPPTPPQ 629
Query: 788 P 788
P
Sbjct: 630 P 630
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 102 bits (254), Expect = 3e-21
Identities = 66/200 (33%), Positives = 105/200 (52%), Gaps = 7/200 (3%)
Query: 18 AFGCDLTEYLESSGQDVPYVLKSCAEFI-ETHGIVDGIYRLSGVTSNIQRLRQEFGSDQC 76
AFG L E+L+ SG+++ +++C + ET +G++R+ S +++L+ C
Sbjct: 249 AFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAAL---DC 305
Query: 77 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136
+ + D H V K Y RELP PL+T+ LYE++T+ S ++ +L + Q
Sbjct: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQ 365
Query: 137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 196
+LPP ++ YLI+ LA +A S M N+A+V PNLL ++ E T AA
Sbjct: 366 KLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN-EGTLAE-MAAAT 423
Query: 197 AVRVQQVVIEFILNHVDQIF 216
+V V VIE I+ H D F
Sbjct: 424 SVHV-VAVIEPIIQHADWFF 442
Score = 34.3 bits (77), Expect = 0.89
Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 722 PANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGP----GNL 777
P QS+ G S P+P P + P + P A ++ P +L
Sbjct: 651 PGGQSSSGTSQHPPSLSPKP-----PTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSL 705
Query: 778 SPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQ 821
SP P PPP P ++TP++ +K + + L ++ ++Q
Sbjct: 706 SPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQ 749
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 102 bits (254), Expect = 3e-21
Identities = 66/200 (33%), Positives = 105/200 (52%), Gaps = 7/200 (3%)
Query: 18 AFGCDLTEYLESSGQDVPYVLKSCAEFI-ETHGIVDGIYRLSGVTSNIQRLRQEFGSDQC 76
AFG L E+L+ SG+++ +++C + ET +G++R+ S +++L+ C
Sbjct: 249 AFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAAL---DC 305
Query: 77 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136
+ + D H V K Y RELP PL+T+ LYE++T+ S ++ +L + Q
Sbjct: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQ 365
Query: 137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 196
+LPP ++ YLI+ LA +A S M N+A+V PNLL ++ E T AA
Sbjct: 366 KLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN-EGTLAE-MAAAT 423
Query: 197 AVRVQQVVIEFILNHVDQIF 216
+V V VIE I+ H D F
Sbjct: 424 SVHV-VAVIEPIIQHADWFF 442
Score = 34.3 bits (77), Expect = 0.89
Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 9/104 (8%)
Query: 722 PANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGP----GNL 777
P QS+ G S P+P P + P + P A ++ P +L
Sbjct: 573 PGGQSSSGTSQHPPSLSPKP-----PTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSL 627
Query: 778 SPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQ 821
SP P PPP P ++TP++ +K + + L ++ ++Q
Sbjct: 628 SPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQ 671
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 102 bits (253), Expect = 3e-21
Identities = 57/180 (31%), Positives = 94/180 (52%), Gaps = 2/180 (1%)
Query: 8 QKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQR 66
+++ + FG + + VPY+++ C E IE G+ + GIYR+SGV ++IQ
Sbjct: 997 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1056
Query: 67 LRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEG 126
L+ F + D++ + D++ + KLYFRELP PL T E Y F E ++
Sbjct: 1057 LKAAFDVNN-KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1115
Query: 127 QLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEA 186
+ + + N++ LP ++ T +L+ HL +A + M NLA V+ P LLR E E+
Sbjct: 1116 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1175
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 102 bits (253), Expect = 3e-21
Identities = 57/180 (31%), Positives = 94/180 (52%), Gaps = 2/180 (1%)
Query: 8 QKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQR 66
+++ + FG + + VPY+++ C E IE G+ + GIYR+SGV ++IQ
Sbjct: 1041 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1100
Query: 67 LRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEG 126
L+ F + D++ + D++ + KLYFRELP PL T E Y F E ++
Sbjct: 1101 LKAAFDVNN-KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1159
Query: 127 QLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEA 186
+ + + N++ LP ++ T +L+ HL +A + M NLA V+ P LLR E E+
Sbjct: 1160 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 100 bits (248), Expect = 1e-20
Identities = 58/201 (28%), Positives = 107/201 (53%), Gaps = 11/201 (5%)
Query: 26 YLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQE-FGSDQCPDLTREV 83
YL +G + ++ C + +ET GI + G+YR+ GV S +Q+L F PD+ ++
Sbjct: 389 YLNEAGFNF---VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDI 445
Query: 84 YLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHY 143
L D + S K Y R L PL+TY+L++ F AV + ++ + ++ +LP +
Sbjct: 446 ELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNR 505
Query: 144 RTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQV 203
L+ LI+HL ++ S + M NL +++ P L+R++E AA + ++ Q +
Sbjct: 506 EMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETV------AAMMNIKFQNI 559
Query: 204 VIEFILNHVDQIFNNGAPGSL 224
V+E ++ H ++IF+ S+
Sbjct: 560 VVEILIEHYEKIFHTAPDPSI 580
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 100 bits (248), Expect = 1e-20
Identities = 81/344 (23%), Positives = 151/344 (43%), Gaps = 21/344 (6%)
Query: 11 KRKGAASAFGCDLTEYLES-SGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLR 68
K+ A FG L + + + + +P ++ C + +E G+ GIYR+ G + I ++
Sbjct: 1137 KKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQ 1196
Query: 69 QEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQL 128
+E ++ +D++ + SL K +FR+LP PL T + Y F EA +L
Sbjct: 1197 EELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRL 1256
Query: 129 ARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATG 188
++ +I +LP HY TL++L HL +A S K M RNLA+V+ P L+R+ E T
Sbjct: 1257 KTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMT- 1315
Query: 189 CNGDAAFLAVRVQQVVIEFILNHVDQIF-NNGAPGSLENDENRPIMKSLTLPALSLPMKL 247
+ Q ++E ++ H D F GA L + + S +P + +
Sbjct: 1316 ----HMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTN 1371
Query: 248 V---SLEEAQARSLATNHPARKE------RRENSLPEIVPPMGTLFHTVLELPDNKRKLS 298
+ + AT+ + + + + S +V + + P K + S
Sbjct: 1372 IGRTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPS 1431
Query: 299 SKSKKWKSIF----NLGRSGSDSKSKLSRNGSVFVRGQRLSVEK 338
S + ++F N+ + +D+K + + R Q++ + K
Sbjct: 1432 SSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIAK 1475
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 99.8 bits (247), Expect = 2e-20
Identities = 78/294 (26%), Positives = 139/294 (47%), Gaps = 47/294 (15%)
Query: 37 VLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQ-----EFGSDQCPDLTREVYLQDIHC 90
+++ C +ET GI + G+YR+ GV S +Q+L + S+ D+ E +I
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAE---WEIKT 448
Query: 91 VGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLI 150
+ S K Y R LP PL+ Y+ F +A +E +++ I +++ LP + + L+ L+
Sbjct: 449 ITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLM 508
Query: 151 RHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILN 210
HLA++A+ + M NL +V+ P LLR +E AA + ++ Q +VIE ++
Sbjct: 509 NHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETV------AAIMDIKFQNIVIEILIE 562
Query: 211 HVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRE 270
+ ++IFN T+P +P+ L ++ +S + P+ ER
Sbjct: 563 NHEKIFN-------------------TVP--DMPLTNAQLHLSRKKSSDSKPPSCSER-- 599
Query: 271 NSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRN 324
P+ TLFHTV +++ S + +S+ + S +S S L N
Sbjct: 600 --------PL-TLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPN 644
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 99.8 bits (247), Expect = 2e-20
Identities = 78/294 (26%), Positives = 139/294 (47%), Gaps = 47/294 (15%)
Query: 37 VLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQ-----EFGSDQCPDLTREVYLQDIHC 90
+++ C +ET GI + G+YR+ GV S +Q+L + S+ D+ E +I
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAE---WEIKT 448
Query: 91 VGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLI 150
+ S K Y R LP PL+ Y+ F +A +E +++ I +++ LP + + L+ L+
Sbjct: 449 ITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLM 508
Query: 151 RHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILN 210
HLA++A+ + M NL +V+ P LLR +E AA + ++ Q +VIE ++
Sbjct: 509 NHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETV------AAIMDIKFQNIVIEILIE 562
Query: 211 HVDQIFNNGAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRE 270
+ ++IFN T+P +P+ L ++ +S + P+ ER
Sbjct: 563 NHEKIFN-------------------TVP--DMPLTNAQLHLSRKKSSDSKPPSCSER-- 599
Query: 271 NSLPEIVPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRN 324
P+ TLFHTV +++ S + +S+ + S +S S L N
Sbjct: 600 --------PL-TLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPN 644
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 98.2 bits (243), Expect = 5e-20
Identities = 75/272 (27%), Positives = 128/272 (47%), Gaps = 32/272 (11%)
Query: 11 KRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQ 69
K +G FG D + S+ VP+++K C IE + GIYR++GV + +++L Q
Sbjct: 751 KLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQ 810
Query: 70 EFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFT------------- 116
F + + +L E+ H + ++ KLY R+LP PL+++ LY +
Sbjct: 811 AFENGK--ELV-ELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEA 867
Query: 117 EAVSHCPEEGQ---------LARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHA 167
+A S ++G R++ ++++LPP + +L+YL+RHL I M
Sbjct: 868 KAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP 927
Query: 168 RNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFN---NGAPGSL 224
NL +V+ P LLR + EAT ++ + Q VIE ++ H +F PG
Sbjct: 928 GNLGIVFGPTLLRPRPTEAT--VSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQ 985
Query: 225 ENDENRPIMKSLTLPALSLPMKLV-SLEEAQA 255
+ N+ + +P L +V L+EA A
Sbjct: 986 DESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA 1017
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 97.4 bits (241), Expect = 9e-20
Identities = 61/210 (29%), Positives = 113/210 (53%), Gaps = 13/210 (6%)
Query: 18 AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQC 76
+FG L E+L SG+++ + +++C + G+ + G++R++ S +++L+ C
Sbjct: 252 SFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAAL---DC 308
Query: 77 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136
+ + Y D H + K Y RELP PL+T+ELY+++ +A + ++ +L + N +
Sbjct: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACE 368
Query: 137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 196
+LP +++ + YLI+ L+ ++ + M N+A+V PNLL +A G N
Sbjct: 369 KLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---QAEG-NITEMMT 424
Query: 197 AVRVQQV-VIEFILNHVDQIFNNGAPGSLE 225
V +Q V +IE I+ H D F PG +E
Sbjct: 425 TVSLQIVGIIEPIIQHADWFF----PGEIE 450
Score = 31.2 bits (69), Expect = 7.6
Identities = 42/183 (22%), Positives = 68/183 (37%), Gaps = 21/183 (11%)
Query: 1215 PLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEKPKQDPGAIKSSP 1274
P SQ + G QP + P ++ +Q PA D SP +L + K +P
Sbjct: 605 PGSSQGTACAGTQPGAQPGAQPGASPSPSQPPA-DQSPHTLRKVSK----------KLAP 653
Query: 1275 VDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDNLLSSKLE------- 1327
+ P G G + +S + P G +L S +L
Sbjct: 654 IPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPL 713
Query: 1328 -RPSGGSKPFHRSRP-GRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPTQTVSP 1385
PS + +SRP +P+ PP P +L SS + +L + SP +++S
Sbjct: 714 ASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGM-SPGESMST 772
Query: 1386 GLL 1388
L+
Sbjct: 773 DLV 775
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,299,383
Number of Sequences: 37866
Number of extensions: 3930475
Number of successful extensions: 26518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 1022
Number of HSP's that attempted gapping in prelim test: 18695
Number of HSP's gapped (non-prelim): 7019
length of query: 1444
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1329
effective length of database: 13,892,928
effective search space: 18463701312
effective search space used: 18463701312
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.