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Search of human proteins with 18641362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18641362 protein tyrosine phosphatase, receptor type, C
isoform 2 precursor [Homo sapiens]
(1143 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 2352 0.0
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 2290 0.0
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 2290 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 471 e-132
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 471 e-132
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 471 e-132
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 438 e-122
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 433 e-121
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 397 e-110
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 397 e-110
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 397 e-110
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 397 e-110
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 397 e-110
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 397 e-110
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 396 e-110
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 396 e-110
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 396 e-110
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 396 e-110
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 396 e-110
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 356 8e-98
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 356 8e-98
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 347 5e-95
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 347 5e-95
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 337 4e-92
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 330 4e-90
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 322 1e-87
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 317 4e-86
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 317 4e-86
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 315 2e-85
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 310 4e-84
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 2352 bits (6094), Expect = 0.0
Identities = 1143/1143 (100%), Positives = 1143/1143 (100%)
Query: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP 60
MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP
Sbjct: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP 60
Query: 61 SKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSI 120
SKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSI
Sbjct: 61 SKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSI 120
Query: 121 SHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQ 180
SHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQ
Sbjct: 121 SHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQ 180
Query: 181 CGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSE 240
CGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSE
Sbjct: 181 CGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSE 240
Query: 241 AAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYI 300
AAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYI
Sbjct: 241 AAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYI 300
Query: 301 IAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVE 360
IAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVE
Sbjct: 301 IAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVE 360
Query: 361 AGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFL 420
AGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFL
Sbjct: 361 AGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFL 420
Query: 421 AFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYK 480
AFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYK
Sbjct: 421 AFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYK 480
Query: 481 RKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDA 540
RKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDA
Sbjct: 481 RKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDA 540
Query: 541 GSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCA 600
GSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCA
Sbjct: 541 GSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCA 600
Query: 601 EYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG 660
EYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG
Sbjct: 601 EYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG 660
Query: 661 VPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYG 720
VPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYG
Sbjct: 661 VPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYG 720
Query: 721 YVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSP 780
YVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSP
Sbjct: 721 YVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSP 780
Query: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE
Sbjct: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
Query: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE
Sbjct: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
Query: 901 LKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYT 960
LKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYT
Sbjct: 901 LKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYT 960
Query: 961 NWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALL 1020
NWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALL
Sbjct: 961 NWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALL 1020
Query: 1021 NLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQE 1080
NLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQE
Sbjct: 1021 NLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQE 1080
Query: 1081 DKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALN 1140
DKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALN
Sbjct: 1081 DKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALN 1140
Query: 1141 QGS 1143
QGS
Sbjct: 1141 QGS 1143
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 2290 bits (5935), Expect = 0.0
Identities = 1115/1122 (99%), Positives = 1117/1122 (99%), Gaps = 3/1122 (0%)
Query: 25 SPTPSP---TDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE 81
+PTP +DAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE
Sbjct: 135 NPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE 194
Query: 82 TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE 141
TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE
Sbjct: 195 TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE 254
Query: 142 KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE
Sbjct: 255 KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
Query: 202 YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL 261
YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL
Sbjct: 315 YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL 374
Query: 262 CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP 321
CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP
Sbjct: 375 CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP 434
Query: 322 PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL 381
PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL
Sbjct: 435 PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL 494
Query: 382 QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL 441
QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL
Sbjct: 495 QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL 554
Query: 442 HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501
HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF
Sbjct: 555 HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614
Query: 502 SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561
SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA
Sbjct: 615 SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674
Query: 562 AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621
AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN
Sbjct: 675 AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734
Query: 622 QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681
QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF
Sbjct: 735 QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794
Query: 682 FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741
FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL
Sbjct: 795 FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854
Query: 742 IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN 801
IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN
Sbjct: 855 IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN 914
Query: 802 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861
QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM
Sbjct: 915 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974
Query: 862 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921
SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG
Sbjct: 975 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034
Query: 922 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981
DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV
Sbjct: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094
Query: 982 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041
KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL
Sbjct: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154
Query: 1042 RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP 1101
RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP
Sbjct: 1155 RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP 1214
Query: 1102 LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1143
LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Sbjct: 1215 LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1256
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/61 (62%), Positives = 45/61 (73%), Gaps = 3/61 (4%)
Query: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP 60
MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPT L ++ ++ P S + T T A +P
Sbjct: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTG--LTTAKMPSV-PLSSDPLPTHTTAFSP 57
Query: 61 S 61
+
Sbjct: 58 A 58
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 2290 bits (5934), Expect = 0.0
Identities = 1113/1117 (99%), Positives = 1115/1117 (99%)
Query: 27 TPSPTDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFT 86
T + +DAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFT
Sbjct: 188 TANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFT 247
Query: 87 AKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLH 146
AKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLH
Sbjct: 248 AKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLH 307
Query: 147 DCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDS 206
DCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDS
Sbjct: 308 DCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDS 367
Query: 207 EILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKE 266
EILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKE
Sbjct: 368 EILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKE 427
Query: 267 TEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVW 326
TEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVW
Sbjct: 428 TEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVW 487
Query: 327 NMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTD 386
NMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTD
Sbjct: 488 NMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTD 547
Query: 387 YTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRS 446
YTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRS
Sbjct: 548 YTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRS 607
Query: 447 CNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPI 506
CNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPI
Sbjct: 608 CNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPI 667
Query: 507 KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPR 566
KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPR
Sbjct: 668 KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPR 727
Query: 567 DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRC 626
DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRC
Sbjct: 728 DETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRC 787
Query: 627 PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI 686
PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI
Sbjct: 788 PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI 847
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 747 VEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENK 806
VEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENK
Sbjct: 908 VEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENK 967
Query: 807 SKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKP 866
SKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKP
Sbjct: 968 SKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKP 1027
Query: 867 EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVD 926
EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVD
Sbjct: 1028 EVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVD 1087
Query: 927 LKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLP 986
LKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLP
Sbjct: 1088 LKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLP 1147
Query: 987 QKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP 1046
QKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP
Sbjct: 1148 QKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARP 1207
Query: 1047 GMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPE 1106
GMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPE
Sbjct: 1208 GMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPE 1267
Query: 1107 KLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1143
KLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Sbjct: 1268 KLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1304
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/61 (62%), Positives = 45/61 (73%), Gaps = 3/61 (4%)
Query: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP 60
MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPT L ++ ++ P S + T T A +P
Sbjct: 1 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTG--LTTAKMPSV-PLSSDPLPTHTTAFSP 57
Query: 61 S 61
+
Sbjct: 58 A 58
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 471 bits (1212), Expect = e-132
Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)
Query: 416 LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 466
++A + L+IV I +L +L YK H + + E VE L
Sbjct: 147 MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206
Query: 467 --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 524
P+ D L E R++AD+ +LF EF ++P + + A K N+ KNRYV+IL
Sbjct: 207 RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266
Query: 525 PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584
PYD++RV L+ + G S+YINAS+I+G++E K+IAAQGP++ETV+DFWRMIWEQ
Sbjct: 267 PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326
Query: 585 IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 638
IVMVT +E KCA+YWP ++G +G++ V + DY ++K ++ N
Sbjct: 327 IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 639 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 698
+K + R +T FTSWPD GVP P +LK ++V A + ++G IVVHCSAGVGRTG
Sbjct: 385 RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441
Query: 699 TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 758
T++ IDAML+ + E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+ +G+TE+
Sbjct: 442 TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501
Query: 759 LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 817
++ L +L + + P + + LE EF++L S + + GN N KNR +IPY
Sbjct: 502 VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561
Query: 818 DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 875
++NRV P+K EE + Y+NASFI Y + + IA+QGP
Sbjct: 562 EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600
Query: 876 LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 934
L TI DFW+MI++ K IVMLTEL+ QE CAQYW +G +YGDI V+LK ++
Sbjct: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
Query: 935 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994
+YT+R + +++ SR + Q+ + W +P++ K +IS+I V QK +
Sbjct: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715
Query: 995 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054
H P+ +HC G+ +TG FCAL +LE + E ++D+FQ VK+LR RP MV T EQ
Sbjct: 716 NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1055 YQFLYDVI 1062
Y+F Y V+
Sbjct: 772 YEFCYKVV 779
Score = 197 bits (501), Expect = 5e-50
Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)
Query: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
P N KNR + I+PY++NRV + G+ ++Y+NAS+IDG+++ YIA+QGP T++
Sbjct: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606
Query: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
DFWRMIWE K+ IVM+T EE + KCA+YWPS +G ++GD+ V++ + + C Y +
Sbjct: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664
Query: 632 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 690
+ L + N +E + R++ F WP+ G+P D ++ + V PI VHC
Sbjct: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723
Query: 691 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 749
SAG GRTGT+ + +LE ++AE +DV+ V LR QR MVQ QY ++ + EY
Sbjct: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
Score = 160 bits (404), Expect = 8e-39
Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
EF LP+ T ++EENK KNR N++PYD++RV L E DSD
Sbjct: 235 EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINASFI Y + IAAQGP +ET+ DFW+MI+++ IVM+T LK
Sbjct: 286 ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335
Query: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 958
+ CAQYW +G TYG+I V ++D YT+R F ++ + RK R + Q+
Sbjct: 336 RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395
Query: 959 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1018
+T+W +P P ++ ++ VK PQ + +++HC G +TG F
Sbjct: 396 FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445
Query: 1019 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
+ +L+ TE VD++ V +R R MV T QY F+Y + Y
Sbjct: 446 IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 471 bits (1212), Expect = e-132
Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)
Query: 416 LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 466
++A + L+IV I +L +L YK H + + E VE L
Sbjct: 156 MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 215
Query: 467 --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 524
P+ D L E R++AD+ +LF EF ++P + + A K N+ KNRYV+IL
Sbjct: 216 RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 275
Query: 525 PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584
PYD++RV L+ + G S+YINAS+I+G++E K+IAAQGP++ETV+DFWRMIWEQ
Sbjct: 276 PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 335
Query: 585 IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 638
IVMVT +E KCA+YWP ++G +G++ V + DY ++K ++ N
Sbjct: 336 IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 393
Query: 639 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 698
+K + R +T FTSWPD GVP P +LK ++V A + ++G IVVHCSAGVGRTG
Sbjct: 394 RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 450
Query: 699 TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 758
T++ IDAML+ + E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+ +G+TE+
Sbjct: 451 TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 510
Query: 759 LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 817
++ L +L + + P + + LE EF++L S + + GN N KNR +IPY
Sbjct: 511 VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 570
Query: 818 DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 875
++NRV P+K EE + Y+NASFI Y + + IA+QGP
Sbjct: 571 EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 609
Query: 876 LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 934
L TI DFW+MI++ K IVMLTEL+ QE CAQYW +G +YGDI V+LK ++
Sbjct: 610 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 669
Query: 935 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994
+YT+R + +++ SR + Q+ + W +P++ K +IS+I V QK +
Sbjct: 670 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 724
Query: 995 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054
H P+ +HC G+ +TG FCAL +LE + E ++D+FQ VK+LR RP MV T EQ
Sbjct: 725 NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 780
Query: 1055 YQFLYDVI 1062
Y+F Y V+
Sbjct: 781 YEFCYKVV 788
Score = 197 bits (501), Expect = 5e-50
Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)
Query: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
P N KNR + I+PY++NRV + G+ ++Y+NAS+IDG+++ YIA+QGP T++
Sbjct: 556 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 615
Query: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
DFWRMIWE K+ IVM+T EE + KCA+YWPS +G ++GD+ V++ + + C Y +
Sbjct: 616 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 673
Query: 632 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 690
+ L + N +E + R++ F WP+ G+P D ++ + V PI VHC
Sbjct: 674 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 732
Query: 691 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 749
SAG GRTGT+ + +LE ++AE +DV+ V LR QR MVQ QY ++ + EY
Sbjct: 733 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 791
Score = 160 bits (404), Expect = 8e-39
Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
EF LP+ T ++EENK KNR N++PYD++RV L E DSD
Sbjct: 244 EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 294
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINASFI Y + IAAQGP +ET+ DFW+MI+++ IVM+T LK
Sbjct: 295 ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 344
Query: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 958
+ CAQYW +G TYG+I V ++D YT+R F ++ + RK R + Q+
Sbjct: 345 RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 404
Query: 959 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1018
+T+W +P P ++ ++ VK PQ + +++HC G +TG F
Sbjct: 405 FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 454
Query: 1019 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
+ +L+ TE VD++ V +R R MV T QY F+Y + Y
Sbjct: 455 IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 502
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 471 bits (1212), Expect = e-132
Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)
Query: 416 LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 466
++A + L+IV I +L +L YK H + + E VE L
Sbjct: 147 MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206
Query: 467 --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 524
P+ D L E R++AD+ +LF EF ++P + + A K N+ KNRYV+IL
Sbjct: 207 RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266
Query: 525 PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584
PYD++RV L+ + G S+YINAS+I+G++E K+IAAQGP++ETV+DFWRMIWEQ
Sbjct: 267 PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326
Query: 585 IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 638
IVMVT +E KCA+YWP ++G +G++ V + DY ++K ++ N
Sbjct: 327 IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 639 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 698
+K + R +T FTSWPD GVP P +LK ++V A + ++G IVVHCSAGVGRTG
Sbjct: 385 RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441
Query: 699 TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 758
T++ IDAML+ + E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+ +G+TE+
Sbjct: 442 TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501
Query: 759 LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 817
++ L +L + + P + + LE EF++L S + + GN N KNR +IPY
Sbjct: 502 VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561
Query: 818 DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 875
++NRV P+K EE + Y+NASFI Y + + IA+QGP
Sbjct: 562 EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600
Query: 876 LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 934
L TI DFW+MI++ K IVMLTEL+ QE CAQYW +G +YGDI V+LK ++
Sbjct: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
Query: 935 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994
+YT+R + +++ SR + Q+ + W +P++ K +IS+I V QK +
Sbjct: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715
Query: 995 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054
H P+ +HC G+ +TG FCAL +LE + E ++D+FQ VK+LR RP MV T EQ
Sbjct: 716 NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
Query: 1055 YQFLYDVI 1062
Y+F Y V+
Sbjct: 772 YEFCYKVV 779
Score = 197 bits (501), Expect = 5e-50
Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)
Query: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
P N KNR + I+PY++NRV + G+ ++Y+NAS+IDG+++ YIA+QGP T++
Sbjct: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606
Query: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
DFWRMIWE K+ IVM+T EE + KCA+YWPS +G ++GD+ V++ + + C Y +
Sbjct: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664
Query: 632 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 690
+ L + N +E + R++ F WP+ G+P D ++ + V PI VHC
Sbjct: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723
Query: 691 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 749
SAG GRTGT+ + +LE ++AE +DV+ V LR QR MVQ QY ++ + EY
Sbjct: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
Score = 160 bits (404), Expect = 8e-39
Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
EF LP+ T ++EENK KNR N++PYD++RV L E DSD
Sbjct: 235 EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINASFI Y + IAAQGP +ET+ DFW+MI+++ IVM+T LK
Sbjct: 286 ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335
Query: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 958
+ CAQYW +G TYG+I V ++D YT+R F ++ + RK R + Q+
Sbjct: 336 RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395
Query: 959 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1018
+T+W +P P ++ ++ VK PQ + +++HC G +TG F
Sbjct: 396 FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445
Query: 1019 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
+ +L+ TE VD++ V +R R MV T QY F+Y + Y
Sbjct: 446 IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 438 bits (1126), Expect = e-122
Identities = 257/674 (38%), Positives = 383/674 (56%), Gaps = 55/674 (8%)
Query: 413 SKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQE-----LVERDDEKQLMNV 467
S+ L+A+L +++ + LL+ Y + K+R + + ++E +++++M +
Sbjct: 44 SQPLLAWLLLPLLLLLLVLLLAAY-FFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL 102
Query: 468 E----------PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNK 517
PI + L E + + AD+ + F EF S+P + + A K N+ K
Sbjct: 103 SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREK 162
Query: 518 NRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI 577
NRY +ILP D++RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+
Sbjct: 163 NRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV 222
Query: 578 WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV 637
WEQK+ IVM+T +E KC +YWP ++G +G++ V + DY I+K I
Sbjct: 223 WEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280
Query: 638 NKKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG 695
+ R V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVG
Sbjct: 281 PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340
Query: 696 RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGET 755
RTGT+I IDAM+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+T
Sbjct: 341 RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400
Query: 756 EVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNV 814
E+++S L +L M + LE EF++L + R + GN N K R +
Sbjct: 401 ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460
Query: 815 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874
IPYD+NRV L + +E + YINASFI Y + + IA QG
Sbjct: 461 IPYDFNRVILSMK-------------------RGQEYTDYINASFIDGYRQKDYFIATQG 501
Query: 875 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKS 933
PL T+ DFW+MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S
Sbjct: 502 PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLS 561
Query: 934 STYTLRVF-----ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK 988
++R F + + + + R V Q+ + W +PAE K +I +I V QK
Sbjct: 562 EAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QK 616
Query: 989 NSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM 1048
+ H P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP M
Sbjct: 617 QQQQTGNH----PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHM 672
Query: 1049 VSTFEQYQFLYDVI 1062
V T EQY+F Y V+
Sbjct: 673 VQTLEQYEFCYKVV 686
Score = 173 bits (439), Expect = 7e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 493 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 551
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 429 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 488
Query: 552 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 611
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 489 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 546
Query: 612 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 666
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 547 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605
Query: 667 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 725
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665
Query: 726 RRQRCLMVQVEAQYILIHQALVEY 749
R QR MVQ QY ++ + ++
Sbjct: 666 RLQRPHMVQTLEQYEFCYKVVQDF 689
Score = 158 bits (399), Expect = 3e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 138 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 188
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 189 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 238
Query: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 959
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 239 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 298
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 299 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 348
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 349 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 395
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 433 bits (1113), Expect = e-121
Identities = 246/603 (40%), Positives = 352/603 (58%), Gaps = 39/603 (6%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI + L E + + AD+ + F EF S+P + + A K N+ KNRY +ILP D+
Sbjct: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+WEQK+ IVM+
Sbjct: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGR 646
T +E KC +YWP ++G +G++ V + DY I+K I + R
Sbjct: 176 TNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPR 233
Query: 647 EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAM 706
V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVGRTGT+I IDAM
Sbjct: 234 LVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM 293
Query: 707 LEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYL 766
+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+TE+++S L +L
Sbjct: 294 MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHL 353
Query: 767 HNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLK 825
M + LE EF++L + R + GN N K R +IPYD+NRV L
Sbjct: 354 QTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS 413
Query: 826 HELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ 885
+ +E + YINASFI Y + + IA QGPL T+ DFW+
Sbjct: 414 MK-------------------RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR 454
Query: 886 MIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF--- 941
MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S ++R F
Sbjct: 455 MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVT 514
Query: 942 --ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 999
+ + + + R V Q+ + W +PAE K +I +I V QK + H
Sbjct: 515 LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QKQQQQTGNH--- 566
Query: 1000 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP MV T EQY+F Y
Sbjct: 567 -PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 625
Query: 1060 DVI 1062
V+
Sbjct: 626 KVV 628
Score = 173 bits (439), Expect = 7e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 493 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 551
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
Query: 552 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 611
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 488
Query: 612 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 666
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 489 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
Query: 667 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 725
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
Query: 726 RRQRCLMVQVEAQYILIHQALVEY 749
R QR MVQ QY ++ + ++
Sbjct: 608 RLQRPHMVQTLEQYEFCYKVVQDF 631
Score = 158 bits (399), Expect = 3e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 80 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 130
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 131 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
Query: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 959
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 290
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 337
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 397 bits (1020), Expect = e-110
Identities = 235/600 (39%), Positives = 334/600 (55%), Gaps = 33/600 (5%)
Query: 462 KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV 521
+ +++ PI + E +R A++ E++SI +F + + N+ KNRY
Sbjct: 1365 ESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYA 1423
Query: 522 DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 581
+++ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ+
Sbjct: 1424 NVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR 1483
Query: 582 ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE 641
+ IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K
Sbjct: 1484 SATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNG 1540
Query: 642 KATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYI 701
+ REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I
Sbjct: 1541 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1600
Query: 702 GIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 761
IDAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV
Sbjct: 1601 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1660
Query: 762 LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYN 820
L+ Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+
Sbjct: 1661 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1720
Query: 821 RVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI 880
RV L+ E S YINASFI Y + + IA QGPL ET
Sbjct: 1721 RVCLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761
Query: 881 GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLR 939
DFW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR
Sbjct: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821
Query: 940 VFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 999
F++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G
Sbjct: 1822 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG------ 1874
Query: 1000 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
P+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1875 -PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1933
Score = 198 bits (503), Expect = 3e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1817
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1818 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1876
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 1877 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1936
Query: 747 VEY 749
+EY
Sbjct: 1937 LEY 1939
Score = 155 bits (392), Expect = 2e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 1393 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1436
Query: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 1437 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492
Query: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1602
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1603 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
Score = 33.9 bits (76), Expect = 0.91
Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)
Query: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577
Query: 280 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 332
Y +++LKP T+Y A+ +A G A + SAPP V ++V
Sbjct: 578 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 632
Query: 333 TSDNSMHVKCRPP 345
T ++ V RPP
Sbjct: 633 T---AILVSWRPP 642
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 397 bits (1020), Expect = e-110
Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)
Query: 423 LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 468
++ V I L+V+ ++ + S + ++Q + +D E + +N +
Sbjct: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
Query: 469 ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 525
PI L + +R A++G F E++SI +F + + N+ KNRY +++
Sbjct: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1386
Query: 526 YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 585
YD++RV L+ I+G GS+YINA+YIDG+++ YIA QGP ET+ DFWRM+WEQ+ +
Sbjct: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446
Query: 586 VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 645
VM+TR EE +R KC +YWP+ GT G + V + Y ++ + +K +
Sbjct: 1447 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1503
Query: 646 REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 705
RE+ QF +WPDHGVPE P +L RRV A + +GP+VVHCSAGVGRTG +I IDA
Sbjct: 1504 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1563
Query: 706 MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 765
MLE ++ E VD+YG+V +R QR MVQ E QY+ IH+AL+E G TEV L+ +
Sbjct: 1564 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1623
Query: 766 LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 824
+ + + P + +E EF+ L S ++ ++ I N NK KNR N++PY+ RV L
Sbjct: 1624 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1683
Query: 825 KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 884
+ E S YINASF+ Y + + IA QGPL E+ DFW
Sbjct: 1684 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1724
Query: 885 QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 943
+M+++ +IVMLT+L+ +E C QYW E Y VD Y LR F++
Sbjct: 1725 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784
Query: 944 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
++ SRT+ Q+Q+T+W + +P + I I V K ++ +G P+
Sbjct: 1785 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1836
Query: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
+HC G +TG+F L +LE E VVD+FQ VK LR RP MV T +QYQ Y
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
Score = 197 bits (500), Expect = 6e-50
Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS++DG+++ + YIA QGP E
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
+ +DFWRM+WE +T+IVM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1776
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R + QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1777 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY L ++A
Sbjct: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895
Query: 747 VEY 749
+EY
Sbjct: 1896 LEY 1898
Score = 156 bits (395), Expect = 9e-38
Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)
Query: 801 NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 860
N E NK KNR +NVI YD++RV L D S YINA++I
Sbjct: 1371 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1411
Query: 861 MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 919
Y K IA QGPL ET+GDFW+M+++++ +VM+T L+ + C QYW G +T
Sbjct: 1412 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1471
Query: 920 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 979
G I+V L DT + +TYT+R F L S + R + Q+Q+ W +P P +++ ++
Sbjct: 1472 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1531
Query: 980 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1039
VK P + P+++HC G +TG F + +LE + E+ VDI+ V
Sbjct: 1532 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1581
Query: 1040 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1077
+R R MV T +QY F+++ + + +V N
Sbjct: 1582 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1619
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 397 bits (1020), Expect = e-110
Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)
Query: 423 LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 468
++ V I L+V+ ++ + S + ++Q + +D E + +N +
Sbjct: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
Query: 469 ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 525
PI L + +R A++G F E++SI +F + + N+ KNRY +++
Sbjct: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1377
Query: 526 YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 585
YD++RV L+ I+G GS+YINA+YIDG+++ YIA QGP ET+ DFWRM+WEQ+ +
Sbjct: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437
Query: 586 VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 645
VM+TR EE +R KC +YWP+ GT G + V + Y ++ + +K +
Sbjct: 1438 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1494
Query: 646 REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 705
RE+ QF +WPDHGVPE P +L RRV A + +GP+VVHCSAGVGRTG +I IDA
Sbjct: 1495 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1554
Query: 706 MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 765
MLE ++ E VD+YG+V +R QR MVQ E QY+ IH+AL+E G TEV L+ +
Sbjct: 1555 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1614
Query: 766 LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 824
+ + + P + +E EF+ L S ++ ++ I N NK KNR N++PY+ RV L
Sbjct: 1615 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1674
Query: 825 KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 884
+ E S YINASF+ Y + + IA QGPL E+ DFW
Sbjct: 1675 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1715
Query: 885 QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 943
+M+++ +IVMLT+L+ +E C QYW E Y VD Y LR F++
Sbjct: 1716 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775
Query: 944 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
++ SRT+ Q+Q+T+W + +P + I I V K ++ +G P+
Sbjct: 1776 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1827
Query: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
+HC G +TG+F L +LE E VVD+FQ VK LR RP MV T +QYQ Y
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
Score = 197 bits (500), Expect = 6e-50
Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS++DG+++ + YIA QGP E
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
+ +DFWRM+WE +T+IVM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1767
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R + QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1768 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY L ++A
Sbjct: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886
Query: 747 VEY 749
+EY
Sbjct: 1887 LEY 1889
Score = 156 bits (395), Expect = 9e-38
Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)
Query: 801 NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 860
N E NK KNR +NVI YD++RV L D S YINA++I
Sbjct: 1362 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1402
Query: 861 MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 919
Y K IA QGPL ET+GDFW+M+++++ +VM+T L+ + C QYW G +T
Sbjct: 1403 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1462
Query: 920 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 979
G I+V L DT + +TYT+R F L S + R + Q+Q+ W +P P +++ ++
Sbjct: 1463 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1522
Query: 980 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1039
VK P + P+++HC G +TG F + +LE + E+ VDI+ V
Sbjct: 1523 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1572
Query: 1040 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1077
+R R MV T +QY F+++ + + +V N
Sbjct: 1573 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1610
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 464 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 924 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 982
Query: 524 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 983 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1042
Query: 584 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 1043 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1099
Query: 644 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159
Query: 704 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219
Query: 764 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279
Query: 823 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 1280 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320
Query: 883 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380
Query: 942 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1432
Query: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
Score = 198 bits (503), Expect = 3e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1374
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1375 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1433
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 1434 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1493
Query: 747 VEY 749
+EY
Sbjct: 1494 LEY 1496
Score = 155 bits (392), Expect = 2e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 950 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 993
Query: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 994 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1049
Query: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1050 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1159
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213
Score = 32.3 bits (72), Expect = 2.6
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568
Query: 280 KYDLQNLKPYTKYVLSLHA 298
Y +++LKP T+Y L A
Sbjct: 569 SYVVEDLKPNTEYAFRLAA 587
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 464 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 1329 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 1387
Query: 524 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 1388 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1447
Query: 584 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 1448 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1504
Query: 644 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 1505 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1564
Query: 704 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1624
Query: 764 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 1625 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1684
Query: 823 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 1685 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725
Query: 883 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785
Query: 942 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1786 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1837
Query: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1838 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
Score = 198 bits (503), Expect = 3e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1779
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1780 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1838
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 1839 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1898
Query: 747 VEY 749
+EY
Sbjct: 1899 LEY 1901
Score = 155 bits (392), Expect = 2e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 1355 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1398
Query: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 1399 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1454
Query: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1455 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1564
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
Score = 33.9 bits (76), Expect = 0.91
Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)
Query: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
Query: 280 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 332
Y +++LKP T+Y A+ +A G A + SAPP V ++V
Sbjct: 565 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 619
Query: 333 TSDNSMHVKCRPP 345
T ++ V RPP
Sbjct: 620 T---AILVSWRPP 629
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 397 bits (1019), Expect = e-110
Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)
Query: 464 LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523
+++ PI + E +R A++ E++SI +F + + N+ KNRY ++
Sbjct: 920 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 978
Query: 524 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583
+ YD++RV L I G GS+YINA+Y+DG++ YIA QGP ET DFWRM+WEQ++
Sbjct: 979 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1038
Query: 584 VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643
IVM+TR EE +R KC +YWP+ GT +G + V + + ++ ++ +K +
Sbjct: 1039 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1095
Query: 644 TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703
REV QFT+WPDHGVPE P L RRV + +GPIVVHCSAGVGRTG +I I
Sbjct: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155
Query: 704 DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763
DAMLE ++ E VDVYG+V +R QR MVQ E QY IH+AL+E G TEV L+
Sbjct: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215
Query: 764 PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822
Y+ + + +P + +E EF+RL + ++ ++ I N NK KNR N++PY+ RV
Sbjct: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Query: 823 PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882
L+ E S YINASFI Y + + IA QGPL ET D
Sbjct: 1276 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316
Query: 883 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941
FW+M+++ ++VMLT+L+ +E C QYW E Y VD Y LR F
Sbjct: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376
Query: 942 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001
++ ++ SRTV Q+Q+T+W + +P + I I V K ++ +G P
Sbjct: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1428
Query: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
+ +HC G +TG+F L +LE E VVDIFQ VK LR RP MV T ++YQF Y
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
Score = 198 bits (503), Expect = 3e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E +Y +QA
Sbjct: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1489
Query: 747 VEY 749
+EY
Sbjct: 1490 LEY 1492
Score = 155 bits (392), Expect = 2e-37
Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)
Query: 781 LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840
L E++ + + + +H N E NK KNR +NVI YD++RV L+
Sbjct: 946 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 989
Query: 841 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900
+ S YINA+++ Y IA QGPL ET GDFW+M+++++ IVM+T
Sbjct: 990 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1045
Query: 901 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959
L+ + C QYW G +TYG I+V L DT + +T+ +R F L + + R V Q+Q+
Sbjct: 1046 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105
Query: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
T W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1155
Query: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
+LE + E+ VD++ V +R R MV T +QY F+++ + N +V
Sbjct: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209
Score = 32.3 bits (72), Expect = 2.6
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279
+KT G PG+P + + + ++W+PP Q S + L + + + ++
Sbjct: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
Query: 280 KYDLQNLKPYTKYVLSLHA 298
Y +++LKP T+Y L A
Sbjct: 565 SYVVEDLKPNTEYAFRLAA 583
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 926 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 984
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 985 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1044
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 1045 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1101
Query: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161
Query: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1221
Query: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 1222 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1279
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 1280 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1322
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1323 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1382
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1383 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1434
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1487
Score = 197 bits (501), Expect = 5e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1371
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1372 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
Query: 747 VEY 749
+EY
Sbjct: 1491 LEY 1493
Score = 156 bits (395), Expect = 9e-38
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 927 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 981
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 982 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1022
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082
Query: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1135
Query: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1136 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192
Query: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
F++D + N +V N
Sbjct: 1193 IFIHDALLEAVTCGNTEVPARN 1214
Score = 34.3 bits (77), Expect = 0.70
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 484
Query: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 485 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 544
Query: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 298
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 545 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 584
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 1336 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1394
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 1395 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1454
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 1455 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1511
Query: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1512 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1571
Query: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1631
Query: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 1632 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1689
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 1690 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1732
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1733 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1792
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1793 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1844
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1897
Score = 197 bits (501), Expect = 5e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1781
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1782 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900
Query: 747 VEY 749
+EY
Sbjct: 1901 LEY 1903
Score = 156 bits (395), Expect = 9e-38
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 1337 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1391
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 1392 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1432
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492
Query: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1545
Query: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1546 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1602
Query: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
F++D + N +V N
Sbjct: 1603 IFIHDALLEAVTCGNTEVPARN 1624
Score = 39.3 bits (90), Expect = 0.022
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
Query: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Query: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
Query: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Score = 32.3 bits (72), Expect = 2.6
Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
Query: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
Query: 342 CRPP 345
R P
Sbjct: 732 WRSP 735
Score = 32.3 bits (72), Expect = 2.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 787 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 843
Query: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 844 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 901
Query: 398 YPGEPFI 404
GE +
Sbjct: 902 GFGEEMV 908
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1381
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 1382 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1441
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 1442 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1498
Query: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1499 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1558
Query: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1618
Query: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 1619 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1676
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 1677 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1719
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1720 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1779
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1780 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1831
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1884
Score = 197 bits (501), Expect = 5e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1768
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1769 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887
Query: 747 VEY 749
+EY
Sbjct: 1888 LEY 1890
Score = 156 bits (395), Expect = 9e-38
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 1324 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1378
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 1379 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1419
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479
Query: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1532
Query: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1533 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1589
Query: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
F++D + N +V N
Sbjct: 1590 IFIHDALLEAVTCGNTEVPARN 1611
Score = 39.3 bits (90), Expect = 0.022
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 474
Query: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 475 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 534
Query: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 535 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 592
Query: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Score = 32.3 bits (72), Expect = 2.6
Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)
Query: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659
Query: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 718
Query: 342 CRPP 345
R P
Sbjct: 719 WRSP 722
Score = 32.3 bits (72), Expect = 2.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 774 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 830
Query: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 888
Query: 398 YPGEPFI 404
GE +
Sbjct: 889 GFGEEMV 895
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 1327 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1385
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 1386 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1445
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 1446 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1502
Query: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562
Query: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622
Query: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1680
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 1681 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1723
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1724 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1783
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1784 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1835
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1888
Score = 197 bits (501), Expect = 5e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1772
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1773 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1831
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 1832 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1891
Query: 747 VEY 749
+EY
Sbjct: 1892 LEY 1894
Score = 156 bits (395), Expect = 9e-38
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 1328 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1382
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 1383 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1423
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483
Query: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1536
Query: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1537 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1593
Query: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
F++D + N +V N
Sbjct: 1594 IFIHDALLEAVTCGNTEVPARN 1615
Score = 39.3 bits (90), Expect = 0.022
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)
Query: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
Query: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Query: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 317
L Y + E+ + ++ Y LQ LKP + Y L A + + +A + T
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605
Query: 318 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 361
+S P + +++ + S S+ V +PP +NG Y ++ A
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Score = 33.5 bits (75), Expect = 1.2
Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 37/218 (16%)
Query: 232 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 281
PQ I C S ++ +++W PP N T IK T D L + + KY
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672
Query: 282 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 341
L+ L+ +T+Y +++ A+ + + T + P + V + S+ V
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731
Query: 342 CRP--PRDRNGPHERYHLEV-------EAGNTLVRNESHKNC-DFRVKDLQYSTDY--TF 389
R P ++G Y + G ++++ + D + LQ T Y T
Sbjct: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791
Query: 390 KAYFHNGD--------------YPGEPFILHHSTSYNS 413
AY GD PG+P ++ + T N+
Sbjct: 792 TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 829
Score = 32.3 bits (72), Expect = 2.6
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)
Query: 283 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 342
+ L+P T Y L++ AY K S TT + P + ++ T N+ ++
Sbjct: 778 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 834
Query: 343 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 397
PP D GP + Y L ++E TL S K F D+ Y F+ N
Sbjct: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 892
Query: 398 YPGEPFI 404
GE +
Sbjct: 893 GFGEEMV 899
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 396 bits (1018), Expect = e-110
Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)
Query: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
PI L + +R A++ F E++SI +F + + N+ KNRY +++ YD+
Sbjct: 925 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 983
Query: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
+RV LS I G GS+Y+NA+YIDG+++ YIA QG ET DFWRMIWEQ++ +VM+
Sbjct: 984 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1043
Query: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 648
T+ EE +R KC +YWPS GT G V V + Y ++ + K + REV
Sbjct: 1044 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1100
Query: 649 THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 708
QFT+WPDHGVPE P L RRV + +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1101 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1160
Query: 709 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 768
++ E VD+YG+V +R QR MVQ E QYI IH AL+E G TEV L+ Y+
Sbjct: 1161 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1220
Query: 769 MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ + + + +E EF+RL S ++ ++ I N NK KNR N++PY+ RV L+
Sbjct: 1221 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1278
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
E S YINASFI Y + + IA QGPL ET DFW+M+
Sbjct: 1279 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1321
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
++ ++VMLT+L+ +E C QYW E Y VD Y LR F++ +
Sbjct: 1322 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1381
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ SRTV Q+Q+T+W + +P + I I V K ++ +G P+ +HC
Sbjct: 1382 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1433
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
G +TG+F L +LE E VVDIFQ VK LR RP MV T +QYQF Y
Sbjct: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1486
Score = 197 bits (501), Expect = 5e-50
Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A P N+ KNR V+I+PY+ RV L I G GS+YINAS+IDG+++ + YIA QGP E
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
T +DFWRM+WE +T++VM+T+ E R KC +YWP+ E + + VV P
Sbjct: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686
YI+++ + + ++ R V QFT WP+ GVP+ + +V+ F GPI
Sbjct: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VHCSAGVGRTG +I + +LE + E VD++ V LR QR MVQ E QY ++A
Sbjct: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1489
Query: 747 VEY 749
+EY
Sbjct: 1490 LEY 1492
Score = 156 bits (395), Expect = 9e-38
Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ + EL ++ +K D E++ + + + +H N E NK KNR +NVI
Sbjct: 926 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 980
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L S + SD Y+NA++I Y K IA QG L
Sbjct: 981 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1021
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 935
ET GDFW+MI++++ +VM+T+L+ + C QYW G +T+G ++V L DT + +T
Sbjct: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081
Query: 936 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 995
Y +R F L + + R V Q+Q+T W +P P ++ ++ VK P
Sbjct: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1134
Query: 996 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1055
+ P+++HC G +TG F + +LE + E+ VDI+ V +R R MV T +QY
Sbjct: 1135 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191
Query: 1056 QFLYDVIASTYPAQNGQVKKNN 1077
F++D + N +V N
Sbjct: 1192 IFIHDALLEAVTCGNTEVPARN 1213
Score = 34.3 bits (77), Expect = 0.70
Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)
Query: 154 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 201
+ TTI ++WK E +T D TQ++ + + + D++ + NL P+
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487
Query: 202 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 259
Y + +S I + T G PG+P E+ +++W PP+ + N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547
Query: 260 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 298
L Y + E+ + ++ Y LQ LKP + Y L A
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 587
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 356 bits (913), Expect = 8e-98
Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)
Query: 442 HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501
H R+C D + RD + + V AD+L + K +G F E++++P
Sbjct: 848 HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 900
Query: 502 SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561
+ A++ N+NKNRY +I+ YD++RV L ++GD S+YINA+YIDG+ PR YIA
Sbjct: 901 TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959
Query: 562 AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621
QGP ETV DFWRMIW++ + IVMVT E R KC YWP + T +GD+ V +
Sbjct: 960 TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1016
Query: 622 QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681
+ + +Y+I+ V KK RE+ FTSWPDHGVP LL R+V +
Sbjct: 1017 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1075
Query: 682 FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741
+GPIVVHCSAG GRTG +I ID ML+ E E VD++ V +LR QR +VQ E QY+
Sbjct: 1076 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1135
Query: 742 IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 797
+H A++E G T + + E +N+ + DP + S ++ EFQ L P R
Sbjct: 1136 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1194
Query: 798 HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 857
IG N KNR+ +V+P D +P ++ E S YINA
Sbjct: 1195 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1234
Query: 858 SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 917
+ + S+ +P + Q PL T+ DFW+++F +VML E+ + C QYW E
Sbjct: 1235 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1292
Query: 918 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 973
YG I+V+ D R+F + + R R V QY W + P +
Sbjct: 1293 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1352
Query: 974 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1033
L+ +++ +++ Q + EG ++HC +G ++G FCA+ ++ E + + ++D
Sbjct: 1353 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
Query: 1034 IFQVVKALRKARPGMVSTFEQYQFLYDV 1061
+F +VK LR + MV T EQY+F+Y+V
Sbjct: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
Score = 165 bits (417), Expect = 3e-40
Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 814
+ +++L ++ MK+ + + E++ LP + SW T ++EN++KNR N+
Sbjct: 869 IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 921
Query: 815 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874
I YD++RV L D D SD YINA++I Y +P IA QG
Sbjct: 922 ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 962
Query: 875 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 934
P++ET+ DFW+MI+Q IVM+T L + C +YW + + YGDI+V L +T+ +
Sbjct: 963 PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1022
Query: 935 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994
Y +R F ++ + R + + +T+W +P L+ ++ VK P +
Sbjct: 1023 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1076
Query: 995 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054
+ P+++HC G+ +TG F A+ +L+ AE E VVDIF V+ LR R +V T EQ
Sbjct: 1077 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132
Query: 1055 YQFLYDVI 1062
Y F++D I
Sbjct: 1133 YVFVHDAI 1140
Score = 131 bits (330), Expect = 3e-30
Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)
Query: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
P N +KNR +D+LP D L ++G++ SNYINA+ +D K+P ++ Q P TV
Sbjct: 1200 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1258
Query: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
DFWR++++ + +VM+ E C +YWP G +G + V+ D I
Sbjct: 1259 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1314
Query: 632 QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 686
+ I N G R V H+Q+ WP + P LLK+ RR+ + + G
Sbjct: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1374
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VVHC G GR+GT+ I ++ E ++ +N +DV+ V LR + MV+ QY +++
Sbjct: 1375 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1434
Query: 747 VEY 749
+EY
Sbjct: 1435 LEY 1437
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 356 bits (913), Expect = 8e-98
Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)
Query: 442 HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501
H R+C D + RD + + V AD+L + K +G F E++++P
Sbjct: 867 HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 919
Query: 502 SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561
+ A++ N+NKNRY +I+ YD++RV L ++GD S+YINA+YIDG+ PR YIA
Sbjct: 920 TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 978
Query: 562 AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621
QGP ETV DFWRMIW++ + IVMVT E R KC YWP + T +GD+ V +
Sbjct: 979 TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1035
Query: 622 QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681
+ + +Y+I+ V KK RE+ FTSWPDHGVP LL R+V +
Sbjct: 1036 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094
Query: 682 FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741
+GPIVVHCSAG GRTG +I ID ML+ E E VD++ V +LR QR +VQ E QY+
Sbjct: 1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1154
Query: 742 IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 797
+H A++E G T + + E +N+ + DP + S ++ EFQ L P R
Sbjct: 1155 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1213
Query: 798 HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 857
IG N KNR+ +V+P D +P ++ E S YINA
Sbjct: 1214 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1253
Query: 858 SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 917
+ + S+ +P + Q PL T+ DFW+++F +VML E+ + C QYW E
Sbjct: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1311
Query: 918 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 973
YG I+V+ D R+F + + R R V QY W + P +
Sbjct: 1312 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1371
Query: 974 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1033
L+ +++ +++ Q + EG ++HC +G ++G FCA+ ++ E + + ++D
Sbjct: 1372 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
Query: 1034 IFQVVKALRKARPGMVSTFEQYQFLYDV 1061
+F +VK LR + MV T EQY+F+Y+V
Sbjct: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1452
Score = 165 bits (417), Expect = 3e-40
Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 814
+ +++L ++ MK+ + + E++ LP + SW T ++EN++KNR N+
Sbjct: 888 IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 940
Query: 815 IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874
I YD++RV L D D SD YINA++I Y +P IA QG
Sbjct: 941 ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 981
Query: 875 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 934
P++ET+ DFW+MI+Q IVM+T L + C +YW + + YGDI+V L +T+ +
Sbjct: 982 PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1041
Query: 935 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994
Y +R F ++ + R + + +T+W +P L+ ++ VK P +
Sbjct: 1042 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1095
Query: 995 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054
+ P+++HC G+ +TG F A+ +L+ AE E VVDIF V+ LR R +V T EQ
Sbjct: 1096 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1151
Query: 1055 YQFLYDVI 1062
Y F++D I
Sbjct: 1152 YVFVHDAI 1159
Score = 131 bits (330), Expect = 3e-30
Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)
Query: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571
P N +KNR +D+LP D L ++G++ SNYINA+ +D K+P ++ Q P TV
Sbjct: 1219 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1277
Query: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631
DFWR++++ + +VM+ E C +YWP G +G + V+ D I
Sbjct: 1278 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1333
Query: 632 QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 686
+ I N G R V H+Q+ WP + P LLK+ RR+ + + G
Sbjct: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1393
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
VVHC G GR+GT+ I ++ E ++ +N +DV+ V LR + MV+ QY +++
Sbjct: 1394 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1453
Query: 747 VEY 749
+EY
Sbjct: 1454 LEY 1456
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 347 bits (889), Expect = 5e-95
Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)
Query: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 531
AD+L + K A EG F E++S S P A+K N+ KNRY +I+ YD++RV
Sbjct: 883 ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 940
Query: 532 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 591
L I GD S+YIN +YIDG+ P YIA QGP ET+ DFWRM+W + I+MVT
Sbjct: 941 RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1000
Query: 592 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 651
E R KC +YWP + T + D+ V + + + +Y+I+ V K+ RE+
Sbjct: 1001 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1056
Query: 652 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 711
FT WPDHGVP LL R+V + S +GP+VVHCSAG GRTG +I ID ML+ E
Sbjct: 1057 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1116
Query: 712 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 771
E VD+Y V +LR +R MVQ E QY+ IH A++E G+T V S++ ++M K
Sbjct: 1117 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1176
Query: 772 RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
DP + S ++ EF+ L P+ R I N KNR +++P D +P
Sbjct: 1177 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1234
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
++ E S YINA+ + SY +P I Q PL T+ DFW+++
Sbjct: 1235 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1275
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
+VML ++ ++C QYW E G +G I+V+ D R+F + ++
Sbjct: 1276 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1333
Query: 947 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
R R V Q+Q+ W + P + + +I+ V + + N EG +
Sbjct: 1334 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1386
Query: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
+HC +G ++G FCA+ + E + VD+F VK LR +P MV +QY+F Y+V
Sbjct: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
Score = 160 bits (405), Expect = 6e-39
Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)
Query: 802 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861
++EN+ KNR N+I YD++RV L ++ + D++S+ YIN ++I
Sbjct: 920 KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 960
Query: 862 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921
Y +P IA QGP++ETI DFW+M++ I+M+T L + C +YW + + Y
Sbjct: 961 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
Query: 922 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981
DI+V L +T+ + Y +R F + + R + Q+ +T W +P L+ ++ V
Sbjct: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
Query: 982 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041
K K P + PL++HC G+ +TG F + +L+ AE E VVDI+ V+ L
Sbjct: 1081 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1130
Query: 1042 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1094
R R MV T EQY F++D I ++ PA QV+ + +K++ ++K+
Sbjct: 1131 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1188
Query: 1095 DANCVN 1100
+ +N
Sbjct: 1189 EFRTLN 1194
Score = 127 bits (318), Expect = 8e-29
Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)
Query: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
EF+++ V +++ A P N KNR +DILP D L I+G++ SNYINA+
Sbjct: 1189 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1247
Query: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
+D +K+P +I Q P TV DFWR++ + T +VM+ + C +YWP E G
Sbjct: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1303
Query: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 667
G + V+ D I + I N G R V QF WP + P
Sbjct: 1304 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1363
Query: 668 LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
LKL R+V+ + ++G VVHC G GR+GT+ I + E L + VDV+ V
Sbjct: 1364 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1423
Query: 725 LRRQRCLMVQVEAQYILIHQALVEYNQFG 753
LR + MV + QY ++ +EY G
Sbjct: 1424 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1452
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 347 bits (889), Expect = 5e-95
Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)
Query: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 531
AD+L + K A EG F E++S S P A+K N+ KNRY +I+ YD++RV
Sbjct: 896 ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 953
Query: 532 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 591
L I GD S+YIN +YIDG+ P YIA QGP ET+ DFWRM+W + I+MVT
Sbjct: 954 RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1013
Query: 592 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 651
E R KC +YWP + T + D+ V + + + +Y+I+ V K+ RE+
Sbjct: 1014 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1069
Query: 652 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 711
FT WPDHGVP LL R+V + S +GP+VVHCSAG GRTG +I ID ML+ E
Sbjct: 1070 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1129
Query: 712 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 771
E VD+Y V +LR +R MVQ E QY+ IH A++E G+T V S++ ++M K
Sbjct: 1130 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1189
Query: 772 RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
DP + S ++ EF+ L P+ R I N KNR +++P D +P
Sbjct: 1190 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1247
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
++ E S YINA+ + SY +P I Q PL T+ DFW+++
Sbjct: 1248 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1288
Query: 888 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
+VML ++ ++C QYW E G +G I+V+ D R+F + ++
Sbjct: 1289 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1346
Query: 947 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
R R V Q+Q+ W + P + + +I+ V + + N EG +
Sbjct: 1347 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1399
Query: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
+HC +G ++G FCA+ + E + VD+F VK LR +P MV +QY+F Y+V
Sbjct: 1400 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457
Score = 160 bits (405), Expect = 6e-39
Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)
Query: 802 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861
++EN+ KNR N+I YD++RV L ++ + D++S+ YIN ++I
Sbjct: 933 KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 973
Query: 862 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921
Y +P IA QGP++ETI DFW+M++ I+M+T L + C +YW + + Y
Sbjct: 974 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1033
Query: 922 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981
DI+V L +T+ + Y +R F + + R + Q+ +T W +P L+ ++ V
Sbjct: 1034 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
Query: 982 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041
K K P + PL++HC G+ +TG F + +L+ AE E VVDI+ V+ L
Sbjct: 1094 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143
Query: 1042 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1094
R R MV T EQY F++D I ++ PA QV+ + +K++ ++K+
Sbjct: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1201
Query: 1095 DANCVN 1100
+ +N
Sbjct: 1202 EFRTLN 1207
Score = 127 bits (318), Expect = 8e-29
Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)
Query: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
EF+++ V +++ A P N KNR +DILP D L I+G++ SNYINA+
Sbjct: 1202 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1260
Query: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
+D +K+P +I Q P TV DFWR++ + T +VM+ + C +YWP E G
Sbjct: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1316
Query: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 667
G + V+ D I + I N G R V QF WP + P
Sbjct: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
Query: 668 LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
LKL R+V+ + ++G VVHC G GR+GT+ I + E L + VDV+ V
Sbjct: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
Query: 725 LRRQRCLMVQVEAQYILIHQALVEYNQFG 753
LR + MV + QY ++ +EY G
Sbjct: 1437 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1465
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 337 bits (864), Expect = 4e-92
Identities = 210/561 (37%), Positives = 293/561 (52%), Gaps = 42/561 (7%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YIDG++ P YIA QGP E
Sbjct: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHE 965
Query: 569 TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628
TV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V + + +
Sbjct: 966 TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAE 1022
Query: 629 YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVV 688
Y+++ + + REV FT WPDHGVP LL RRV + +GPIVV
Sbjct: 1023 YVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081
Query: 689 HCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE 748
HCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI IH A++E
Sbjct: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141
Query: 749 YNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----HIGNQEE 804
GET + + E +M + D + S L+ EFQ L S R Q I
Sbjct: 1142 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCSIACLPR 1200
Query: 805 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 864
N KNR +++P D +P ++ E S YINA+ + SY
Sbjct: 1201 NHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAALMDSYR 1240
Query: 865 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDI 923
+P I Q PL T+ DFW++++ IVML E+ + C QYW EG YG I
Sbjct: 1241 QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPI 1298
Query: 924 EVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKELISMIQV 980
+V+ R+F + + R V Q+QY W S ++P + + +I
Sbjct: 1299 QVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ 1358
Query: 981 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA 1040
V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+F VK
Sbjct: 1359 VEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
Query: 1041 LRKARPGMVSTFEQYQFLYDV 1061
LR ++P MV EQY+F YDV
Sbjct: 1412 LRNSKPNMVEAPEQYRFCYDV 1432
Score = 163 bits (412), Expect = 1e-39
Identities = 100/306 (32%), Positives = 158/306 (51%), Gaps = 34/306 (11%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 876
YD++RV L+ + D SSD YINA++I Y +P IA QGP+
Sbjct: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDGYQRPSHYIATQGPV 963
Query: 877 KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY 936
ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V + + + Y
Sbjct: 964 HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEY 1023
Query: 937 TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 996
+R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1024 VVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-------- 1075
Query: 997 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1056
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV T EQY
Sbjct: 1076 --AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYI 1133
Query: 1057 FLYDVI 1062
F++D I
Sbjct: 1134 FIHDAI 1139
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1235
Query: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1291
Query: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 667
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 1292 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1351
Query: 668 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 1352 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411
Query: 725 LRRQRCLMVQVEAQYILIHQALVEY 749
LR + MV+ QY + +EY
Sbjct: 1412 LRNSKPNMVEAPEQYRFCYDVALEY 1436
Score = 33.9 bits (76), Expect = 0.91
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 258 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 312
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
Query: 313 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 357
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 330 bits (847), Expect = 4e-90
Identities = 210/567 (37%), Positives = 293/567 (51%), Gaps = 48/567 (8%)
Query: 509 ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID------GFKEPRKYIAA 562
A+K N+ KNRY +I+ YD++RV L + D S+YINA+YID G++ P YIA
Sbjct: 906 AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIAT 965
Query: 563 QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQ 622
QGP ETV DFWRMIW++++ IVMVT E R KC +YWP + T +GD V +
Sbjct: 966 QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVE 1022
Query: 623 HKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF 682
+ +Y+++ + + REV FT WPDHGVP LL RRV +
Sbjct: 1023 MEPLAEYVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081
Query: 683 SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI 742
+GPIVVHCSAG GRTG YI ID ML+ E E VD+Y V LR +R MVQ E QYI I
Sbjct: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1141
Query: 743 HQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----H 798
H A++E GET + + E +M + D + S L+ EFQ L S R Q
Sbjct: 1142 HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCS 1200
Query: 799 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 858
I N KNR +++P D +P ++ E S YINA+
Sbjct: 1201 IACLPRNHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAA 1240
Query: 859 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGK 917
+ SY +P I Q PL T+ DFW++++ IVML E+ + C QYW EG
Sbjct: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGM 1298
Query: 918 QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKEL 974
YG I+V+ R+F + + R V Q+QY W S ++P +
Sbjct: 1299 LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSF 1358
Query: 975 ISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDI 1034
+ +I V++ + EG +IHC +G ++G+FCA+ ++E + + VVD+
Sbjct: 1359 LKLILQVEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1411
Query: 1035 FQVVKALRKARPGMVSTFEQYQFLYDV 1061
F VK LR ++P MV EQY+F YDV
Sbjct: 1412 FHAVKTLRNSKPNMVEAPEQYRFCYDV 1438
Score = 156 bits (395), Expect = 9e-38
Identities = 100/312 (32%), Positives = 158/312 (50%), Gaps = 40/312 (12%)
Query: 757 VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 816
+ +++L +++ MK D E+ F+ + SW + +++N++KNR N+I
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922
Query: 817 YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEVMI 870
YD++RV L+ + D SSD YINA++I Y +P I
Sbjct: 923 YDHSRVILQPV---------EDDPSSD----------YINANYIDIWLYRDGYQRPSHYI 963
Query: 871 AAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDT 930
A QGP+ ET+ DFW+MI+Q + IVM+T L + C +YW + + YGD +V +
Sbjct: 964 ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEM 1023
Query: 931 DKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNS 990
+ + Y +R F L + R V Q+ +T W +P L+S I+ VK P
Sbjct: 1024 EPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-- 1081
Query: 991 SEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVS 1050
+ P+++HC G+ +TG + + +L+ AE E VVDI+ VKALR R MV
Sbjct: 1082 --------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQ 1133
Query: 1051 TFEQYQFLYDVI 1062
T EQY F++D I
Sbjct: 1134 TEEQYIFIHDAI 1145
Score = 122 bits (306), Expect = 2e-27
Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)
Query: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
EFQ++ V + ++ A P N +KNR++D+LP D L I+G++ SNYINA+
Sbjct: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1241
Query: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
+D +++P +I Q P TV DFWR++++ T IVM+ + C +YWP EEG
Sbjct: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1297
Query: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 667
+G + V+ D I + I N G V Q+ W H VP
Sbjct: 1298 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1357
Query: 668 LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
LKL +V + G ++HC G GR+G + I ++E ++ +N VDV+ V
Sbjct: 1358 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1417
Query: 725 LRRQRCLMVQVEAQYILIHQALVEY 749
LR + MV+ QY + +EY
Sbjct: 1418 LRNSKPNMVEAPEQYRFCYDVALEY 1442
Score = 33.9 bits (76), Expect = 0.91
Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)
Query: 258 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 312
N T+CY E++ DCL++D ++ + +L PYT L + I+ + +
Sbjct: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480
Query: 313 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 357
T P V ++ TS +N + + + P D NG +Y +
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 322 bits (826), Expect = 1e-87
Identities = 211/680 (31%), Positives = 338/680 (49%), Gaps = 72/680 (10%)
Query: 416 LIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHAD-- 473
+++ L F+ +V + +L+ K + ++ + + R + PI D
Sbjct: 1643 IVSALTFICLVVLVGILIYWRKCF-----QTAHFYLEDSTSPRVISTPPTPIFPISDDVG 1697
Query: 474 -ILLETYKRKIAD--EGRLFLAEFQSIPRVFSK---------FPIKEARKPFNQNKNRYV 521
I ++ + + +AD F EF+++ + + + P N++KNRY+
Sbjct: 1698 AIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI 1757
Query: 522 DILPYDYNRVELSEINGDAG--SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE 579
+I+ YD++RV+L+++ G ++YINA+Y+DG+ P+ YIAAQGP T +DFWRMIWE
Sbjct: 1758 NIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE 1817
Query: 580 QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK 639
VIVM+T E R KC +YWP+ +G+ +G+ +V + Y ++ + N
Sbjct: 1818 HNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
Query: 640 KEKA-------TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSA 692
K K +GR VT +T WPD GVPE +L R+ GP+VVHCSA
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
Query: 693 GVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF 752
GVGRTGTYI +D+ML+ ++ E V+++G++ +R QR +VQ E QY+ IH LVE
Sbjct: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
Query: 753 GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRN 811
ETEV S +H Y+ N P+ + LE +FQ L ++ + ++ N+ KNR
Sbjct: 1996 KETEVLDSHIHAYV-NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRT 2054
Query: 812 SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIA 871
S++IP + +RV + S S E + YINAS+IM Y++ I
Sbjct: 2055 SSIIPVERSRVGI--------------------SSLSGEGTDYINASYIMGYYQSNEFII 2094
Query: 872 AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG--DIEVDL-- 927
Q PL TI DFW+MI+ +++VM+ + ++ ++ YW + +V L
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESFKVTLMA 2153
Query: 928 ---KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQK 984
K ++ F L ++ V +Q W P + +I V+K++
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPI--SKTFELISVIKEE 2211
Query: 985 LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA 1044
++ P+++H G G FCAL L+ E E VD++QV K +
Sbjct: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261
Query: 1045 RPGMVSTFEQYQFLYDVIAS 1064
RPG+ + EQYQFLY VI S
Sbjct: 2262 RPGVFADIEQYQFLYKVILS 2281
Score = 150 bits (380), Expect = 5e-36
Identities = 92/287 (32%), Positives = 145/287 (50%), Gaps = 36/287 (12%)
Query: 796 TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYI 855
T N +NK KNR N++ YD++RV L ++ +E D + + YI
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKL------AQLAEKDG-----------KLTDYI 1783
Query: 856 NASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-G 914
NA+++ Y +P+ IAAQGPLK T DFW+MI++ V+VIVM+T L + C QYW
Sbjct: 1784 NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA 1843
Query: 915 EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK--------RKDSRTVYQYQYTNWSVEQ 966
+G + YG+ V K + YT+R F LR++K R R V QY YT W
Sbjct: 1844 DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMG 1903
Query: 967 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESA 1026
+P +++ ++ K H P+++HC G +TG + L ++L+
Sbjct: 1904 VPEYSLPVLTFVRKAAYA----------KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953
Query: 1027 ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073
+ E V+IF +K +R R +V T EQY F++D + ++ +V
Sbjct: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 317 bits (812), Expect = 4e-86
Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)
Query: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 530
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 867 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919
Query: 531 VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 590
V+L + GD ++YINA+YIDG+ +IA QGP+ E V DFWRM+W++ + IVM+T+
Sbjct: 920 VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 979
Query: 591 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 650
E R KC+ YWP E + +GD+ + + + + +Y+++ + + A EV
Sbjct: 980 LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1035
Query: 651 IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 710
FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D ML+
Sbjct: 1036 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1095
Query: 711 EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 770
E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE M
Sbjct: 1096 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1155
Query: 771 KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ DP S S L EFQ L S I N+ KNR+ +V+P D +P
Sbjct: 1156 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1212
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
S+D DS++ YINA+ SY + I PL+ T DFW+++
Sbjct: 1213 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1255
Query: 888 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 945
+ IVML +L + C QYW E G+Q YG +EV+ RVF +++
Sbjct: 1256 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1315
Query: 946 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1002
R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 1316 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1366
Query: 1003 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY F YDV
Sbjct: 1367 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1425
Score = 137 bits (344), Expect = 8e-32
Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)
Query: 791 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 849
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 888 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932
Query: 850 EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 909
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L + C
Sbjct: 933 ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 988
Query: 910 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 969
++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W +P
Sbjct: 989 SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1048
Query: 970 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1029
L++ I+ VK P + P++IHC G+ +TG + L +L+ AE E
Sbjct: 1049 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1098
Query: 1030 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062
VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1099 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1131
Score = 114 bits (285), Expect = 5e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 402 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 459
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 1070 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1129
Query: 460 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 510
E L I TYK I EFQ++ V ++E A
Sbjct: 1130 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1189
Query: 511 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 570
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 1190 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1248
Query: 571 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 629
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 1249 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1306
Query: 630 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 686
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 1307 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1366
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 1367 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1426
Query: 747 VEY 749
+EY
Sbjct: 1427 LEY 1429
Score = 35.0 bits (79), Expect = 0.41
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 175 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 232
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 233 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 286
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
Query: 287 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 344
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
Query: 345 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 374
+ R P Y +E E L R ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
Score = 32.3 bits (72), Expect = 2.6
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 242 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 289
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
Query: 290 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 348
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 349 NGPHERYHLEVEA 361
NG +Y + ++
Sbjct: 514 NGLITQYEISYQS 526
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 317 bits (812), Expect = 4e-86
Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)
Query: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 530
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 877 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 929
Query: 531 VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 590
V+L + GD ++YINA+YIDG+ +IA QGP+ E V DFWRM+W++ + IVM+T+
Sbjct: 930 VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 989
Query: 591 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 650
E R KC+ YWP E + +GD+ + + + + +Y+++ + + A EV
Sbjct: 990 LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1045
Query: 651 IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 710
FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D ML+
Sbjct: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
Query: 711 EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 770
E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE M
Sbjct: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
Query: 771 KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
+ DP S S L EFQ L S I N+ KNR+ +V+P D +P
Sbjct: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1222
Query: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
S+D DS++ YINA+ SY + I PL+ T DFW+++
Sbjct: 1223 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1265
Query: 888 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 945
+ IVML +L + C QYW E G+Q YG +EV+ RVF +++
Sbjct: 1266 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1325
Query: 946 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1002
R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 1326 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1376
Query: 1003 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY F YDV
Sbjct: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1435
Score = 137 bits (344), Expect = 8e-32
Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)
Query: 791 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 849
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 898 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 942
Query: 850 EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 909
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L + C
Sbjct: 943 ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 998
Query: 910 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 969
++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W +P
Sbjct: 999 SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1058
Query: 970 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1029
L++ I+ VK P + P++IHC G+ +TG + L +L+ AE E
Sbjct: 1059 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1108
Query: 1030 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062
VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1109 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1141
Score = 114 bits (285), Expect = 5e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 402 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 459
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 1080 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1139
Query: 460 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 510
E L I TYK I EFQ++ V ++E A
Sbjct: 1140 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1199
Query: 511 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 570
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 1200 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1258
Query: 571 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 629
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 1259 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1316
Query: 630 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 686
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 1317 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1376
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
Query: 747 VEY 749
+EY
Sbjct: 1437 LEY 1439
Score = 35.0 bits (79), Expect = 0.41
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 175 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 232
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 233 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 286
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
Query: 287 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 344
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
Query: 345 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 374
+ R P Y +E E L R ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
Score = 32.3 bits (72), Expect = 2.6
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 242 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 289
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
Query: 290 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 348
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 349 NGPHERYHLEVEA 361
NG +Y + ++
Sbjct: 514 NGLITQYEISYQS 526
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 315 bits (806), Expect = 2e-85
Identities = 201/598 (33%), Positives = 307/598 (51%), Gaps = 59/598 (9%)
Query: 490 FLAEFQSIPRVFSKFPI--KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG--SNYI 545
F +F+ + R + I + + P N++KNRY++IL YD++RV+L + G S+YI
Sbjct: 848 FSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYI 907
Query: 546 NASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS 605
NA+Y+DG+ + + YIA QGP T +DFWRMIWEQ +IVM+T E R KC +YWP+
Sbjct: 908 NANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 967
Query: 606 MEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----------TGREVTHIQFTS 655
E + +G+++V + K Y +++ +I N K K R V +T
Sbjct: 968 --ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQ 1025
Query: 656 WPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK 715
WPD GVPE +L RR +A +GP++VHCSAGVGRTGTYI ID+ML+ ++ ++
Sbjct: 1026 WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST 1085
Query: 716 VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPP 775
V+V G++ +R QR +VQ E QYI IH AL+E ETEV+ ++LH Y++++
Sbjct: 1086 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG 1145
Query: 776 SEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRNSNVIPYDYNRVPLKHELEMSKES 834
+ + LE +F+ + + + Q+E NK KNRNS+V+P + RV L M
Sbjct: 1146 GK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM---- 1200
Query: 835 EHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV 894
+ + YINAS+IM Y++ I Q PL T DFW+MI+ ++
Sbjct: 1201 ---------------KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI 1245
Query: 895 IVMLTELKH-GDQEICAQYWGEGKQ-------TYGDIEVDLKDTDKSSTYTLRVFELRHS 946
IVML + + + E YW ++ T I D + F L +
Sbjct: 1246 IVMLPDNQSLAEDEFV--YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEAT 1303
Query: 947 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1006
+ V +Q W P +I V+K++ ++ P ++H
Sbjct: 1304 QDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRDG----------PTIVHD 1351
Query: 1007 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS 1064
G+ G+ CAL L + E E VD+FQV K + RPG+ + EQYQF+Y + S
Sbjct: 1352 EYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS 1409
Score = 150 bits (380), Expect = 5e-36
Identities = 94/305 (30%), Positives = 153/305 (50%), Gaps = 40/305 (13%)
Query: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
E QR + + +H N ENK KNR N++ YD++RV L+ K+S+H
Sbjct: 854 EVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLRPL--PGKDSKH------- 903
Query: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
S YINA+++ Y K + IA QGPLK T DFW+MI+++ +IVM+T L
Sbjct: 904 --------SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVE 955
Query: 904 GDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----------RKDS 951
+ C QYW E + YG+I V LK T + YT+R F +R++K R++
Sbjct: 956 KGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNE 1015
Query: 952 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1011
R V QY YT W +P +++ ++ S + ++ P+L+HC G
Sbjct: 1016 RVVIQYHYTQWPDMGVPEYALPVLTFVR----------RSSAARMPETGPVLVHCSAGVG 1065
Query: 1012 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1071
+TG + + ++L+ + + V++ +K +R R +V T EQY F++D + +
Sbjct: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
Query: 1072 QVKKN 1076
+V N
Sbjct: 1126 EVSSN 1130
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 310 bits (795), Expect = 4e-84
Identities = 208/605 (34%), Positives = 302/605 (49%), Gaps = 55/605 (9%)
Query: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 530
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 867 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919
Query: 531 VELSEINGDAGSNYINASYID------GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584
V+L + GD ++YINA+YID G+ +IA QGP+ E V DFWRM+W++ +
Sbjct: 920 VKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSS 979
Query: 585 IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT 644
IVM+T+ E R KC+ YWP E + +GD+ + + + + +Y+++ + + A
Sbjct: 980 IVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
Query: 645 GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID 704
EV FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D
Sbjct: 1037 -HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLD 1095
Query: 705 AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP 764
ML+ E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE
Sbjct: 1096 VMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA 1155
Query: 765 YLHNMKKRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNR 821
M + DP S S L EFQ L S I N+ KNR+ +V+P D
Sbjct: 1156 TYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RC 1214
Query: 822 VPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG 881
+P S+D DS++ YINA+ SY + I PL+ T
Sbjct: 1215 LPFL--------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTP 1255
Query: 882 DFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLR 939
DFW++++ IVML +L + C QYW E G+Q YG +EV+ R
Sbjct: 1256 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1315
Query: 940 VFELRHSKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 996
VF +++ R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 1316 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-- 1371
Query: 997 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1056
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY
Sbjct: 1372 -----TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH 1426
Query: 1057 FLYDV 1061
F YDV
Sbjct: 1427 FCYDV 1431
Score = 130 bits (328), Expect = 5e-30
Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 36/279 (12%)
Query: 791 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 849
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 888 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932
Query: 850 EPSKYINASFI------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L
Sbjct: 933 ----YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 988
Query: 904 GDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWS 963
+ C++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W
Sbjct: 989 VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1048
Query: 964 VEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLL 1023
+P L++ I+ VK P + P++IHC G+ +TG + L +L
Sbjct: 1049 EHGVPYHATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVML 1098
Query: 1024 ESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062
+ AE E VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1099 DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
Score = 114 bits (285), Expect = 5e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 402 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 459
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 1076 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1135
Query: 460 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 510
E L I TYK I EFQ++ V ++E A
Sbjct: 1136 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1195
Query: 511 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 570
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 1196 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1254
Query: 571 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 629
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 1255 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1312
Query: 630 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 686
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 1313 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
Query: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
Query: 747 VEY 749
+EY
Sbjct: 1433 LEY 1435
Score = 35.0 bits (79), Expect = 0.41
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 175 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 232
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 233 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 286
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
Query: 287 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 344
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
Query: 345 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 374
+ R P Y +E E L R ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
Score = 32.3 bits (72), Expect = 2.6
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 242 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 289
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
Query: 290 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 348
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
Query: 349 NGPHERYHLEVEA 361
NG +Y + ++
Sbjct: 514 NGLITQYEISYQS 526
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,293,504
Number of Sequences: 37866
Number of extensions: 2175777
Number of successful extensions: 10729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 109
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 9009
Number of HSP's gapped (non-prelim): 1091
length of query: 1143
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1030
effective length of database: 13,968,660
effective search space: 14387719800
effective search space used: 14387719800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.