Search of human proteins with 17149832

Search of human proteins with 17149832

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17149832 G protein-coupled receptor kinase interacting
ArfGAP 2 isoform 2 [Homo sapiens]
         (631 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17149832 G protein-coupled receptor kinase interacting ArfGAP...  1265   0.0  
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP...  1177   0.0  
gi|206725420 G protein-coupled receptor kinase interacting ArfGA...  1170   0.0  
gi|206725422 G protein-coupled receptor kinase interacting ArfGA...   906   0.0  
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP...   906   0.0  
gi|206725415 G protein-coupled receptor kinase interacting ArfGA...   902   0.0  
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo...   716   0.0  
gi|146231998 G protein-coupled receptor kinase interactor 1 isof...   713   0.0  
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]              135   1e-31
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]               131   2e-30
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]               131   2e-30
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]         128   1e-29
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]           128   1e-29
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]    127   3e-29
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do...   125   2e-28
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do...   125   2e-28
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do...   121   2e-27
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat...   120   3e-27
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do...   117   4e-26
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...   111   2e-24
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea...   111   2e-24
gi|7661880 centaurin beta1 [Homo sapiens]                              88   3e-17
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do...    84   4e-16
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    84   4e-16
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,...    80   6e-15
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...    80   6e-15
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    80   7e-15
gi|187608516 centaurin, beta 2 [Homo sapiens]                          77   5e-14
gi|46094081 development and differentiation enhancing factor 1 [...    72   1e-12
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai...    71   3e-12

>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 2 [Homo sapiens]
          Length = 631

 Score = 1265 bits (3273), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
           SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420

Query: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKASRLEKQNSTPESDYDNTPNDMEPDGMGSSR 480
           SDGPVTVQEFMEVKNALVASEAKIQQLMKASRLEKQNSTPESDYDNTPNDMEPDGMGSSR
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKASRLEKQNSTPESDYDNTPNDMEPDGMGSSR 480

Query: 481 KGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDS 540
           KGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDS
Sbjct: 481 KGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDS 540

Query: 541 YIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDV 600
           YIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDV
Sbjct: 541 YIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDV 600

Query: 601 QLVTQQVIQCAYDIAKAAKQLVTITTKENNN 631
           QLVTQQVIQCAYDIAKAAKQLVTITTKENNN
Sbjct: 601 QLVTQQVIQCAYDIAKAAKQLVTITTKENNN 631


>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 3 [Homo sapiens]
          Length = 679

 Score = 1177 bits (3044), Expect = 0.0
 Identities = 603/679 (88%), Positives = 616/679 (90%), Gaps = 48/679 (7%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SLDS 418
           SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK  +L S
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTLQS 420

Query: 419 DLSD------------------------------------GPVTVQE-------FMEVKN 435
           + S+                                     P+++ E       ++ +  
Sbjct: 421 ENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGE 480

Query: 436 ALVASEAKIQQL---MKASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 492
           A    E++++       ASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD
Sbjct: 481 ASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 540

Query: 493 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 552
           GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV
Sbjct: 541 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 600

Query: 553 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 612
           TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY
Sbjct: 601 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 660

Query: 613 DIAKAAKQLVTITTKENNN 631
           DIAKAAKQLVTITTKENNN
Sbjct: 661 DIAKAAKQLVTITTKENNN 679


>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 6 [Homo sapiens]
          Length = 681

 Score = 1170 bits (3026), Expect = 0.0
 Identities = 602/681 (88%), Positives = 615/681 (90%), Gaps = 50/681 (7%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 298
           HKNGQHFIIPQMAD   SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW
Sbjct: 241 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 300

Query: 299 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 358
           LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ
Sbjct: 301 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 360

Query: 359 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK--SL 416
           GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK  +L
Sbjct: 361 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 420

Query: 417 DSDLSD------------------------------------GPVTVQE-------FMEV 433
            S+ S+                                     P+++ E       ++ +
Sbjct: 421 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 480

Query: 434 KNALVASEAKIQQL---MKASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 490
             A    E++++       ASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP
Sbjct: 481 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 540

Query: 491 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 550
           GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV
Sbjct: 541 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 600

Query: 551 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 610
           AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC
Sbjct: 601 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 660

Query: 611 AYDIAKAAKQLVTITTKENNN 631
           AYDIAKAAKQLVTITTKENNN
Sbjct: 661 AYDIAKAAKQLVTITTKENNN 681


>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 5 [Homo sapiens]
          Length = 729

 Score =  906 bits (2342), Expect = 0.0
 Identities = 466/524 (88%), Positives = 470/524 (89%), Gaps = 28/524 (5%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
           SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420

Query: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKA----------------------SRLEKQNS 458
           SDGPVTVQEFMEVKNALVASEAKIQQLMK                       S L KQ +
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT 480

Query: 459 T------PESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVP 496
           T        S+Y +T N        S+R  R  SM   G G  P
Sbjct: 481 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKP 524


>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 1 [Homo sapiens]
          Length = 759

 Score =  906 bits (2342), Expect = 0.0
 Identities = 466/524 (88%), Positives = 470/524 (89%), Gaps = 28/524 (5%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
           SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420

Query: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKA----------------------SRLEKQNS 458
           SDGPVTVQEFMEVKNALVASEAKIQQLMK                       S L KQ +
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT 480

Query: 459 T------PESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVP 496
           T        S+Y +T N        S+R  R  SM   G G  P
Sbjct: 481 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKP 524


>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
           isoform 4 [Homo sapiens]
          Length = 471

 Score =  902 bits (2332), Expect = 0.0
 Identities = 449/451 (99%), Positives = 450/451 (99%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
           SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420

Query: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKAS 451
           SDGPVTVQEFMEVKNALVASEAKIQQLMK +
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKVN 451


>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
           2 [Homo sapiens]
          Length = 761

 Score =  716 bits (1847), Expect = 0.0
 Identities = 374/534 (70%), Positives = 420/534 (78%), Gaps = 44/534 (8%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MS++   +EVCADCS PDP WAS++RG  +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1   MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61  LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ 
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
           HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298

Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
           TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG 
Sbjct: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358

Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQKSL 416
           SLS   DN+EL L++       +S  +DQ DYDSVASDEDTD E    T A+++NR +S+
Sbjct: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411

Query: 417 D-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKAS---------------RLEKQN--- 457
           D SDLSDG VT+QE++E+K AL  SEAK+QQLMK +               +L+ +N   
Sbjct: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471

Query: 458 ----------STPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEP 501
                       P    ++TP  M P G    R  +  SM  PG  L P    P
Sbjct: 472 RQPPGPVPTPPLPSERAEHTP--MAPGGSTHRRDRQAFSMYEPGSALKPFGGPP 523



 Score =  204 bits (520), Expect = 2e-52
 Identities = 107/178 (60%), Positives = 135/178 (75%), Gaps = 4/178 (2%)

Query: 451 SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLP 510
           S+L +  S  +SDY+NT +     G+    +G++   +   +   P+         P LP
Sbjct: 585 SKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLP 640

Query: 511 STEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRT 570
           STEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P  + VR+
Sbjct: 641 STEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRS 700

Query: 571 SLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 628
           SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 701 SLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758


>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
           1 [Homo sapiens]
          Length = 770

 Score =  713 bits (1840), Expect = 0.0
 Identities = 374/542 (69%), Positives = 420/542 (77%), Gaps = 51/542 (9%)

Query: 1   MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
           MS++   +EVCADCS PDP WAS++RG  +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1   MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60

Query: 61  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
           LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61  LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120

Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
           PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ 
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180

Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
           LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240

Query: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
           HKNG H+IIPQMAD         SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299

Query: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
           E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359

Query: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
           AKRRQQG SLS   DN+EL L++       +S  +DQ DYDSVASDEDTD E    T A+
Sbjct: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412

Query: 409 KTNRQKSLD-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKAS---------------R 452
           ++NR +S+D SDLSDG VT+QE++E+K AL  SEAK+QQLMK +               +
Sbjct: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472

Query: 453 LEKQN-------------STPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTA 499
           L+ +N               P    ++TP  M P G    R  +  SM  PG  L P   
Sbjct: 473 LQAENLQLRQPPGPVPTPPLPSERAEHTP--MAPGGSTHRRDRQAFSMYEPGSALKPFGG 530

Query: 500 EP 501
            P
Sbjct: 531 PP 532



 Score =  204 bits (520), Expect = 2e-52
 Identities = 107/178 (60%), Positives = 135/178 (75%), Gaps = 4/178 (2%)

Query: 451 SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLP 510
           S+L +  S  +SDY+NT +     G+    +G++   +   +   P+         P LP
Sbjct: 594 SKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLP 649

Query: 511 STEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRT 570
           STEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P  + VR+
Sbjct: 650 STEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRS 709

Query: 571 SLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 628
           SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 710 SLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 767


>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
          Length = 911

 Score =  135 bits (339), Expect = 1e-31
 Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC  P+P WAS+N G  +C EC  +HR LG H+S+VR L    WPP LL 
Sbjct: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++  + N  ANS+WE +L        G  K  P D     K  +IRAKY+   F+  LP 
Sbjct: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
            D        L +QL  +V   +L   + LL+ G++      +    G T LH++S    
Sbjct: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++  +LL  YG D  ++D+ G TP+ YAR+ G  E A+ L++
Sbjct: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876


>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
          Length = 804

 Score =  131 bits (329), Expect = 2e-30
 Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P+WAS+N G  +C EC  +HR+LG H+S+VR L    WP  L++
Sbjct: 563 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 622

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N  ANS+WE S         GR K +  D     K  +IRAKY+   F+  LPC
Sbjct: 623 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 674

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L + L  +    +L T + LL+ G++           G T LH+A + G 
Sbjct: 675 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 728

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++ A+LL  YG D   +D+ G T + YARQ    E  + L++
Sbjct: 729 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770


>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
          Length = 857

 Score =  131 bits (329), Expect = 2e-30
 Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P+WAS+N G  +C EC  +HR+LG H+S+VR L    WP  L++
Sbjct: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N  ANS+WE S         GR K +  D     K  +IRAKY+   F+  LPC
Sbjct: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L + L  +    +L T + LL+ G++           G T LH+A + G 
Sbjct: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++ A+LL  YG D   +D+ G T + YARQ    E  + L++
Sbjct: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823


>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
          Length = 1192

 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)

Query: 3    KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
            +  + + +C DC  P+P+WAS+N G  +C EC  +HR+LG H+S+VR L    WP  L  
Sbjct: 938  RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997

Query: 63   MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
            ++  + N+ AN +WE       S   GR K + +D     +  +IRAKY+ L F+  L  
Sbjct: 998  VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047

Query: 123  RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
                S + + L +QL ++V+  ++ T L LL+    G         +  +PLH+A++   
Sbjct: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103

Query: 180  ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
            ++  +LL  YGAD   +D+ G+T + YARQ G    A+ L++
Sbjct: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145


>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
          Length = 836

 Score =  128 bits (322), Expect = 1e-29
 Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           +  + + +C DC  P+P+WAS+N G  +C EC  +HR+LG H+S+VR L    WP  L  
Sbjct: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++  + N+ AN +WE       S   GR K + +D     +  +IRAKY+ L F+  L  
Sbjct: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
               S + + L +QL ++V+  ++ T L LL+    G         +  +PLH+A++   
Sbjct: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++  +LL  YGAD   +D+ G+T + YARQ G    A+ L++
Sbjct: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789


>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
          Length = 686

 Score =  127 bits (319), Expect = 3e-29
 Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG H+S+VR L+   WP  L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581

Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178
           C      T   L +QL  +    +L+T + LL+ G+  + N    E  G T LH+A + G
Sbjct: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635

Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678


>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 4 [Homo sapiens]
          Length = 663

 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558

Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612

Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229
            ++ A+LL  YG D   +D+ G T + YARQ    E     V +QY   D+
Sbjct: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661


>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 7 [Homo sapiens]
          Length = 663

 Score =  125 bits (313), Expect = 2e-28
 Identities = 75/222 (33%), Positives = 114/222 (51%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N+ ANSIWE S         GR K   +      K  +IR+KY+   F+  LPC
Sbjct: 508 VMSSIGNDLANSIWEGS-------SQGRTKPT-EKSTREEKERWIRSKYEEKLFLAPLPC 559

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L +QL  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 560 ------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 613

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 614 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655


>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 8 [Homo sapiens]
          Length = 663

 Score =  121 bits (304), Expect = 2e-27
 Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +H SLG  +S+VR L+   WP  L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
           ++ ++ N+ ANSIWE          S + +  P +K     K  +IR+KY+   F+  LP
Sbjct: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558

Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
           C      T   L +QL  +    +L+T + LL+ G++           G T LH+A + G
Sbjct: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612

Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
            ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655


>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
           protein 11 [Homo sapiens]
          Length = 550

 Score =  120 bits (302), Expect = 3e-27
 Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N+ ANSIWE S         G+ K +  +     K  +IR+KY+   F+  LPC
Sbjct: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L + L  +    +L T + LL+ G++           G T LH+A + G 
Sbjct: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542


>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
           domain 5 [Homo sapiens]
          Length = 686

 Score =  117 bits (292), Expect = 4e-26
 Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C D    +P WAS+N G  +C EC  +HRSLG  +S+VR L+   WP  L +
Sbjct: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N+ ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L + L  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678


>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 9 [Homo sapiens]
          Length = 684

 Score =  111 bits (277), Expect = 2e-24
 Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 19/222 (8%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRS G  +S+VR L+   WP  L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRK 530

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N  ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 531 VMSSIGNELANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC 582

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L +QL  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 583 ------TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++  +LL   G D   +D+ G T + YARQ    E    L++
Sbjct: 637 VVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676


>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
           and PH domain 10 [Homo sapiens]
          Length = 684

 Score =  111 bits (277), Expect = 2e-24
 Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 19/222 (8%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           + +R +  C DC   +P WAS+N G  +C EC  +HRS G  +S+VR L+   WP  L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRK 530

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           ++ ++ N  ANSIWE S         G+ K + +      K  +IR+KY+   F+  LPC
Sbjct: 531 VMSSIGNELANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC 582

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
                 T   L +QL  +    +L+T + LL+ G++           G T LH+A + G 
Sbjct: 583 ------TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636

Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
           ++  +LL   G D   +D+ G T + YARQ    E    L++
Sbjct: 637 VVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676


>gi|7661880 centaurin beta1 [Homo sapiens]
          Length = 740

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 83/324 (25%), Positives = 136/324 (41%), Gaps = 57/324 (17%)

Query: 11  CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
           C DC  P P WAS+N G  LC +C  +HRSLG H S+VR L    W P L++++  L N 
Sbjct: 420 CCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479

Query: 71  GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLP--------- 121
             N I+E + ++  ++       + Q+     K  +I AKY    F+ +LP         
Sbjct: 480 IINQIYE-ARVEAMAVKKPGPSCSRQE-----KEAWIHAKYVEKKFLTKLPEIRGRRGGR 533

Query: 122 ---------------------CRDDDSVTAKDLSKQLH-------SSVRTGNLETCLRLL 153
                                 R      ++DL   LH       +S    +L T    L
Sbjct: 534 GRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLG-SLHPGALLFRASGHPPSLPTMADAL 592

Query: 154 SLGAQANFFHPEKGN-TPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGH 212
           + GA  N+ +  + N TPL  A+ A  +L  E L   GA+    DS+G+ P+ +A   GH
Sbjct: 593 AHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGH 652

Query: 213 HELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAK-KKLQ 271
             LA   ++   +L  R              G+  +   M  ++ D+  L + AK ++ +
Sbjct: 653 TGLACLFLKRGADLGAR-----------DSEGRDPLTIAMETANADIVTLLRLAKMREAE 701

Query: 272 SLSNHLFEELAMDVYDEVDRRETD 295
           +      +E  +D++ +     +D
Sbjct: 702 AAQGQAGDETYLDIFRDFSLMASD 725


>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
           domain 1 isoform a [Homo sapiens]
          Length = 1205

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 61/184 (33%), Positives = 84/184 (45%), Gaps = 25/184 (13%)

Query: 11  CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMVETLY 68
           CADC  P P WAS+N    +C  C   HR LG  +S+VR LK     W  TL+++   L 
Sbjct: 305 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 364

Query: 69  NNGANSIWEHSL-----LDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCR 123
           N   N  W  ++     L P+S  S RR               + AKY+   +    P  
Sbjct: 365 NGAGNRFWAANVPPSEALQPSSSPSTRRC-------------HLEAKYREGKYRRYHPLF 411

Query: 124 DDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQ 182
            +     ++L K L ++V T +L     LL  GA  N F  + +  TPL +A +AGQ LQ
Sbjct: 412 GNQ----EELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQ 467

Query: 183 AELL 186
            E L
Sbjct: 468 MEFL 471


>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           1 isoform c [Homo sapiens]
          Length = 1450

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 61/184 (33%), Positives = 84/184 (45%), Gaps = 25/184 (13%)

Query: 11  CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMVETLY 68
           CADC  P P WAS+N    +C  C   HR LG  +S+VR LK     W  TL+++   L 
Sbjct: 550 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 609

Query: 69  NNGANSIWEHSL-----LDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCR 123
           N   N  W  ++     L P+S  S RR               + AKY+   +    P  
Sbjct: 610 NGAGNRFWAANVPPSEALQPSSSPSTRRC-------------HLEAKYREGKYRRYHPLF 656

Query: 124 DDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQ 182
            +     ++L K L ++V T +L     LL  GA  N F  + +  TPL +A +AGQ LQ
Sbjct: 657 GNQ----EELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQ 712

Query: 183 AELL 186
            E L
Sbjct: 713 MEFL 716


>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
           member 1 [Homo sapiens]
          Length = 284

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 56/180 (31%), Positives = 89/180 (49%), Gaps = 19/180 (10%)

Query: 46  SQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKA 104
           S+VR L+   WP  L +++ ++ N+ ANSIWE S          + +  P +K     K 
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS---------SQGQTKPSEKSTREEKE 162

Query: 105 EFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHP 164
            +IR+KY+   F+  LPC D        L +QL  +    +L+T + LL+ G++      
Sbjct: 163 RWIRSKYEEKLFLAPLPCTD------LSLGQQLLRATADEDLQTAILLLAHGSREEVNET 216

Query: 165 ---EKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
                G T LH+A + G ++ A+LL  YG D   +D+ G T + YARQ    E    L++
Sbjct: 217 CGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 276


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 43/111 (38%), Positives = 57/111 (51%), Gaps = 6/111 (5%)

Query: 11  CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
           C DC  PDP WAS+N G  LC EC  +HRSLG H S+VR L    W P LL+++  L N+
Sbjct: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477

Query: 71  GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLP 121
             N I+E          +G RK         +K  +I+ KY    F+ + P
Sbjct: 478 AVNQIYEAQCEG-----AGSRKPTASSS-RQDKEAWIKDKYVEKKFLRKAP 522



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 1/71 (1%)

Query: 138 HSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
           H + R  +L      L+ GA+ N+   E +G TPL  A   G ++  E L   GAD   +
Sbjct: 673 HRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732

Query: 197 DSSGKTPVDYA 207
           DS G+ P+ +A
Sbjct: 733 DSRGRAPLHHA 743



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 1/83 (1%)

Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
           L  +V  G+L  C  LL  GA  N     +G  PLH A+  G+  Q  L    GAD    
Sbjct: 707 LVQAVLGGSLIVCEFLLQNGADVNQ-RDSRGRAPLHHATLLGRTGQVCLFLKRGADQHAL 765

Query: 197 DSSGKTPVDYARQGGHHELAERL 219
           D   + P+  A Q  + ++   L
Sbjct: 766 DQEQRDPLAIAVQAANADIVTLL 788


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           2 [Homo sapiens]
          Length = 1704

 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 60/183 (32%), Positives = 88/183 (48%), Gaps = 15/183 (8%)

Query: 7   SSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMV 64
           S+  CADC  PDP WAS+N    +C +C   HRSLG   S+VR LK   + W   L+++ 
Sbjct: 696 SNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELF 755

Query: 65  ETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRD 124
             + N  AN  W  +L     +       +P +K    +  FI  KY+   F   L    
Sbjct: 756 IVIGNKRANDFWAGNLQKDEEL----HMDSPVEK----RKNFITQKYKEGKFRKTLLA-- 805

Query: 125 DDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK-GNTPLHVASKAGQILQA 183
             S+T ++L+K L ++V   ++   + LL  GA       +   +TP  +A KAGQ LQ 
Sbjct: 806 --SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQM 863

Query: 184 ELL 186
           E L
Sbjct: 864 EFL 866


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 44/109 (40%), Positives = 58/109 (53%), Gaps = 7/109 (6%)

Query: 11  CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
           C DC   DP WAS+N G  LC EC  +HRSLG H S+VR L    W P LL+++  L N+
Sbjct: 414 CCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGND 473

Query: 71  GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHR 119
             N ++E ++        G +K  PQ      K  +IRAKY    FV +
Sbjct: 474 VINRVYEANV-----EKMGIKK--PQPGQRQEKEAYIRAKYVERKFVDK 515



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 30/99 (30%), Positives = 43/99 (43%), Gaps = 3/99 (3%)

Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
           L  +V  G+L TC  LL  GA  N     +G  PLH A+  G   Q  L    GA+    
Sbjct: 645 LIQAVLGGSLVTCEFLLQNGANVNQ-RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT 703

Query: 197 DSSGKTPVDYARQGGHHELAE--RLVEIQYELTDRLAFY 233
           D  GK P+  A +  + ++    RL  +  E+ +    Y
Sbjct: 704 DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLY 742



 Score = 36.2 bits (82), Expect = 0.094
 Identities = 24/78 (30%), Positives = 37/78 (47%), Gaps = 1/78 (1%)

Query: 136 QLHSSVRTGNLETCLRLLSLGAQANFFHPEKGN-TPLHVASKAGQILQAELLAVYGADPG 194
           QL+ +    NL      L+ GA  N+ + E+   TPL  A   G ++  E L   GA+  
Sbjct: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVN 668

Query: 195 TQDSSGKTPVDYARQGGH 212
            +D  G+ P+ +A   GH
Sbjct: 669 QRDVQGRGPLHHATVLGH 686


>gi|46094081 development and differentiation enhancing factor 1
           [Homo sapiens]
          Length = 1129

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 56/211 (26%), Positives = 95/211 (45%), Gaps = 20/211 (9%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           +RL  +++C DC   +P+W S N G   C EC  +HR +G HIS+++ L+      + L 
Sbjct: 446 QRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELL 505

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           + + + NN  N I E +L  P+       K  P   +   K E+I AKY      HR   
Sbjct: 506 LAKNVGNNSFNDIMEANLPSPSP------KPTPSSDMTVRK-EYITAKY----VDHRFSR 554

Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQ--ANFFHP--EKGNTPLHVASKAG 178
           +   + +AK    +L  ++++ +L   +++ + G +       P  E G T LH+A +  
Sbjct: 555 KTCSTSSAK--LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTA 612

Query: 179 QILQAELLAVYGADPGTQDSS---GKTPVDY 206
                 L+     + G  D     G T + Y
Sbjct: 613 DQTSLHLVDFLVQNCGNLDKQTALGNTVLHY 643


>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
           isoform b [Homo sapiens]
          Length = 961

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 64/254 (25%), Positives = 99/254 (38%), Gaps = 41/254 (16%)

Query: 3   KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
           +R+  ++VC DC  PDP+W S N G   C EC  +HR LG H S+++ L       + L 
Sbjct: 428 QRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELL 487

Query: 63  MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
           + + + N G N I E  L    S+     K NP   ++  K ++I AKY    +  +   
Sbjct: 488 LAKNIGNAGFNEIMECCLPAEDSV-----KPNPGSDMNARK-DYITAKYIERRYARKKHA 541

Query: 123 RDD-------DSVTAKDLSKQLHSSVRTGNL-------------ETCLRLLSLGAQANFF 162
            +        ++V  +D+   L +     +L             ET L L          
Sbjct: 542 DNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSL 601

Query: 163 H---------------PEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYA 207
           H                 KG+T LH           +LL    A     + SG+TP+D A
Sbjct: 602 HIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIA 661

Query: 208 RQGGHHELAERLVE 221
           ++  H    E L +
Sbjct: 662 KRLKHEHCEELLTQ 675


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,174,982
Number of Sequences: 37866
Number of extensions: 1093525
Number of successful extensions: 4584
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 284
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 3138
Number of HSP's gapped (non-prelim): 1303
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.