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Search of human proteins with 170784869
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
(807 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 1625 0.0
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 1600 0.0
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 65 3e-10
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 65 3e-10
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 60 8e-09
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 60 8e-09
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 60 8e-09
gi|83415184 transmembrane and tetratricopeptide repeat containin... 59 1e-08
gi|195963398 suppressor of G2 allele of SKP1 isoform a [Homo sap... 57 7e-08
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 57 7e-08
gi|27262638 sperm associated antigen 1 [Homo sapiens] 55 3e-07
gi|27262636 sperm associated antigen 1 [Homo sapiens] 55 3e-07
gi|5730041 suppressor of G2 allele of SKP1 isoform b [Homo sapiens] 54 4e-07
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 54 4e-07
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 54 8e-07
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 54 8e-07
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 51 5e-06
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 51 5e-06
gi|116534937 interferon-induced protein with tetratricopeptide r... 50 6e-06
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 49 2e-05
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 49 2e-05
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 48 4e-05
gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens] 47 5e-05
gi|224809432 transmembrane and tetratricopeptide repeat containi... 47 7e-05
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 47 9e-05
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 47 9e-05
gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens] 47 9e-05
gi|22749211 transmembrane and tetratricopeptide repeat containin... 46 1e-04
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 46 1e-04
gi|4503729 FK506 binding protein 52 [Homo sapiens] 44 5e-04
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 1625 bits (4207), Expect = 0.0
Identities = 807/807 (100%), Positives = 807/807 (100%)
Query: 1 MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ 60
MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ
Sbjct: 1 MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ 60
Query: 61 HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK 120
HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK
Sbjct: 61 HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK 120
Query: 121 ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRIN 180
ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRIN
Sbjct: 121 ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRIN 180
Query: 181 EAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
EAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF
Sbjct: 181 EAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300
FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT
Sbjct: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300
Query: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360
LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML
Sbjct: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360
Query: 361 NDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIE 420
NDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIE
Sbjct: 361 NDPLPGQKASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIE 420
Query: 421 DYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGL 480
DYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGL
Sbjct: 421 DYEEQPGLQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGL 480
Query: 481 AALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSL 540
AALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSL
Sbjct: 481 AALEVMQAVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSL 540
Query: 541 SRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKV 600
SRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKV
Sbjct: 541 SRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKV 600
Query: 601 EDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEE 660
EDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEE
Sbjct: 601 EDLLPIMKQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEE 660
Query: 661 RTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIA 720
RTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIA
Sbjct: 661 RTQLYHAEIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIA 720
Query: 721 YSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPS 780
YSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPS
Sbjct: 721 YSVIVGALMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPS 780
Query: 781 VSETFPTLRSMIEVLNTDSSPRCLKKL 807
VSETFPTLRSMIEVLNTDSSPRCLKKL
Sbjct: 781 VSETFPTLRSMIEVLNTDSSPRCLKKL 807
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 1600 bits (4143), Expect = 0.0
Identities = 807/860 (93%), Positives = 807/860 (93%), Gaps = 53/860 (6%)
Query: 1 MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ 60
MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ
Sbjct: 1 MAPAGCCCCCCFWGGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEHYSPLSLLKQELQ 60
Query: 61 HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK 120
HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK
Sbjct: 61 HRQQQEAPAGGGGCSPQSGDWGDQYSAECGESSFLNFHDSDCEPKGSSPCDSLLSLNTEK 120
Query: 121 ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQ--------- 171
ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQ
Sbjct: 121 ILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAI 180
Query: 172 --------------------------------------------ILSPLGRINEAVNDLT 187
ILSPLGRINEAVNDLT
Sbjct: 181 YGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLT 240
Query: 188 KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLK 247
KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLK
Sbjct: 241 KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLK 300
Query: 248 EAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMM 307
EAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMM
Sbjct: 301 EAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMM 360
Query: 308 LYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQ 367
LYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQ
Sbjct: 361 LYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQ 420
Query: 368 KASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPG 427
KASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPG
Sbjct: 421 KASPEYLKVKYLREYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPG 480
Query: 428 LQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQ 487
LQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQ
Sbjct: 481 LQPHIKDVLHQNFESYKPEVQELICVADRLGSLMQYETPGFLPNKRIHRAMGLAALEVMQ 540
Query: 488 AVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSLSRGFNNH 547
AVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSLSRGFNNH
Sbjct: 541 AVQRTWTNSKVRMNGKTRLMQWRDMFDIAVKWRRIADPDQPVLWLDQMPARSLSRGFNNH 600
Query: 548 INLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIM 607
INLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIM
Sbjct: 601 INLIRGQVINMRYLEYFEKILHFIKDRILVYHGANNPKGLLEVREALEKVHKVEDLLPIM 660
Query: 608 KQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHA 667
KQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHA
Sbjct: 661 KQFNTKTKDGFTVNTKVPSLKDQGKEYDGFTITITGDKVGNILFSVETQTTEERTQLYHA 720
Query: 668 EIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGA 727
EIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGA
Sbjct: 721 EIDALYKDLTAKGKVLILSSEFGEADAVCNLILSLVYYFYNLMPLSRGSSVIAYSVIVGA 780
Query: 728 LMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPSVSETFPT 787
LMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPSVSETFPT
Sbjct: 781 LMASGKEVAGKIPKGKLVDFEAMTAPGSEAFSKVAKSWMNLKSISPSYKTLPSVSETFPT 840
Query: 788 LRSMIEVLNTDSSPRCLKKL 807
LRSMIEVLNTDSSPRCLKKL
Sbjct: 841 LRSMIEVLNTDSSPRCLKKL 860
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/217 (26%), Positives = 95/217 (43%), Gaps = 24/217 (11%)
Query: 136 FATDNDSTNEELAIAYVLIGS-----GLYDEAIRHFSTMLQILSPL--GRIN-----EAV 183
F+T N LA AY +G+ G EAI H+ L++ G IN A
Sbjct: 67 FSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 126
Query: 184 NDLTKAIQLQPSARLYRHRGTLYFISEDYAT----------AHEDFQQSLELNKNQPIAM 233
D+ A+Q SA Y LY + D A + +++E N +A
Sbjct: 127 GDMEGAVQAYVSALQYNP--DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAW 184
Query: 234 LYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLL 293
G F +G + AI F++A+ +F+DAY +LG +E F+ A ++ +AL L
Sbjct: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 244
Query: 294 NQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
+ NH + Y G + A+ ++R ++L+P+
Sbjct: 245 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH 281
Score = 60.5 bits (145), Expect = 6e-09
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 2/144 (1%)
Query: 222 SLELNKNQPIAMLYKGL--TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGN 279
+L + +N +A Y L + RG L+EAIE ++ AL+ K DFID Y +L A G+
Sbjct: 69 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGD 128
Query: 280 FEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKG 339
E A +++ AL N + G +L G L+EA + + ++ +P V G
Sbjct: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
Query: 340 LSHVAMGQFYEGIKAQTKVMLNDP 363
A G+ + I K + DP
Sbjct: 189 CVFNAQGEIWLAIHHFEKAVTLDP 212
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/159 (23%), Positives = 80/159 (50%), Gaps = 1/159 (0%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
+ + G I A++ KA+ L P+ Y + G + + + A + ++L L+ N
Sbjct: 190 VFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 249
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
+ ++ +GL+ AI++++ A++ + F DAY +L A +E G+ A + + A
Sbjct: 250 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTA 309
Query: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEP 329
L L H +L + G+++EA++ +++ L++ P
Sbjct: 310 LRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 348
Score = 53.9 bits (128), Expect = 6e-07
Identities = 46/206 (22%), Positives = 92/206 (44%), Gaps = 31/206 (15%)
Query: 126 KSIAEQKRFPFATDN--DSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRINEAV 183
++I Q FP A N ++ E+ ++A Y+ A+R T L+ L I
Sbjct: 274 RAIELQPHFPDAYCNLANALKEKGSVAEA---EDCYNTALRLCPTHADSLNNLANIKREQ 330
Query: 184 NDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHR 243
++ +A+ RLYR ++ ++A AH + L+ +
Sbjct: 331 GNIEEAV------RLYRKALEVF---PEFAAAHSNLASVLQ-----------------QQ 364
Query: 244 GLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQL 303
G L+EA+ +KEA++ F DAY ++G +E+ + + A + + +A+ +N
Sbjct: 365 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 424
Query: 304 RGMMLYHHGSLQEALKNFKRCLQLEP 329
+ G++ EA+ +++ L+L+P
Sbjct: 425 LASIHKDSGNIPEAIASYRTALKLKP 450
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/180 (23%), Positives = 85/180 (47%), Gaps = 7/180 (3%)
Query: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAH 216
++ E S + +L G++ EA+ +AI++ P+ A Y + G +D A
Sbjct: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
Query: 217 EDFQQSLELNKNQPIAMLYKGLTFFHR--GLLKEAIESFKEALKQKVDFIDAYKSLGQAY 274
+ + +++++N A + L H+ G + EAI S++ ALK K DF DAY +L
Sbjct: 406 QCYTRAIQINP--AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL 463
Query: 275 RELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC 334
+ + ++ E +K + + + ++ +L + HH L F++ + E + +C
Sbjct: 464 QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVH-PHHSMLYPLSHGFRKAI-AERHGNLC 521
Score = 46.6 bits (109), Expect = 9e-05
Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 8/198 (4%)
Query: 166 FSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLE 224
+S + + G++ EA+ A++L+P Y + + D A + + +L+
Sbjct: 82 YSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQ 141
Query: 225 LNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAAT 284
N + G G L+EA + +A++ + +F A+ +LG + G A
Sbjct: 142 YNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAI 201
Query: 285 ESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQ-------YM 337
F+KA+ L+ N + G +L A+ + R L L P + V Y
Sbjct: 202 HHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 261
Query: 338 KGLSHVAMGQFYEGIKAQ 355
+GL +A+ + I+ Q
Sbjct: 262 QGLIDLAIDTYRRAIELQ 279
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/217 (26%), Positives = 95/217 (43%), Gaps = 24/217 (11%)
Query: 136 FATDNDSTNEELAIAYVLIGS-----GLYDEAIRHFSTMLQILSPL--GRIN-----EAV 183
F+T N LA AY +G+ G EAI H+ L++ G IN A
Sbjct: 77 FSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 136
Query: 184 NDLTKAIQLQPSARLYRHRGTLYFISEDYAT----------AHEDFQQSLELNKNQPIAM 233
D+ A+Q SA Y LY + D A + +++E N +A
Sbjct: 137 GDMEGAVQAYVSALQYNP--DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAW 194
Query: 234 LYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLL 293
G F +G + AI F++A+ +F+DAY +LG +E F+ A ++ +AL L
Sbjct: 195 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 254
Query: 294 NQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
+ NH + Y G + A+ ++R ++L+P+
Sbjct: 255 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH 291
Score = 60.5 bits (145), Expect = 6e-09
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 2/144 (1%)
Query: 222 SLELNKNQPIAMLYKGL--TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGN 279
+L + +N +A Y L + RG L+EAIE ++ AL+ K DFID Y +L A G+
Sbjct: 79 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGD 138
Query: 280 FEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKG 339
E A +++ AL N + G +L G L+EA + + ++ +P V G
Sbjct: 139 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 198
Query: 340 LSHVAMGQFYEGIKAQTKVMLNDP 363
A G+ + I K + DP
Sbjct: 199 CVFNAQGEIWLAIHHFEKAVTLDP 222
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/159 (23%), Positives = 80/159 (50%), Gaps = 1/159 (0%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
+ + G I A++ KA+ L P+ Y + G + + + A + ++L L+ N
Sbjct: 200 VFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 259
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
+ ++ +GL+ AI++++ A++ + F DAY +L A +E G+ A + + A
Sbjct: 260 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTA 319
Query: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEP 329
L L H +L + G+++EA++ +++ L++ P
Sbjct: 320 LRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 358
Score = 53.9 bits (128), Expect = 6e-07
Identities = 46/206 (22%), Positives = 92/206 (44%), Gaps = 31/206 (15%)
Query: 126 KSIAEQKRFPFATDN--DSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRINEAV 183
++I Q FP A N ++ E+ ++A Y+ A+R T L+ L I
Sbjct: 284 RAIELQPHFPDAYCNLANALKEKGSVAEA---EDCYNTALRLCPTHADSLNNLANIKREQ 340
Query: 184 NDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHR 243
++ +A+ RLYR ++ ++A AH + L+ +
Sbjct: 341 GNIEEAV------RLYRKALEVF---PEFAAAHSNLASVLQ-----------------QQ 374
Query: 244 GLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQL 303
G L+EA+ +KEA++ F DAY ++G +E+ + + A + + +A+ +N
Sbjct: 375 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 434
Query: 304 RGMMLYHHGSLQEALKNFKRCLQLEP 329
+ G++ EA+ +++ L+L+P
Sbjct: 435 LASIHKDSGNIPEAIASYRTALKLKP 460
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/180 (23%), Positives = 85/180 (47%), Gaps = 7/180 (3%)
Query: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAH 216
++ E S + +L G++ EA+ +AI++ P+ A Y + G +D A
Sbjct: 356 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 415
Query: 217 EDFQQSLELNKNQPIAMLYKGLTFFHR--GLLKEAIESFKEALKQKVDFIDAYKSLGQAY 274
+ + +++++N A + L H+ G + EAI S++ ALK K DF DAY +L
Sbjct: 416 QCYTRAIQINP--AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL 473
Query: 275 RELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC 334
+ + ++ E +K + + + ++ +L + HH L F++ + E + +C
Sbjct: 474 QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVH-PHHSMLYPLSHGFRKAI-AERHGNLC 531
Score = 46.6 bits (109), Expect = 9e-05
Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 8/198 (4%)
Query: 166 FSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLE 224
+S + + G++ EA+ A++L+P Y + + D A + + +L+
Sbjct: 92 YSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQ 151
Query: 225 LNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAAT 284
N + G G L+EA + +A++ + +F A+ +LG + G A
Sbjct: 152 YNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAI 211
Query: 285 ESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQ-------YM 337
F+KA+ L+ N + G +L A+ + R L L P + V Y
Sbjct: 212 HHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 271
Query: 338 KGLSHVAMGQFYEGIKAQ 355
+GL +A+ + I+ Q
Sbjct: 272 QGLIDLAIDTYRRAIELQ 289
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 4/201 (1%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
I LG++ A+NDL + I L+P Y HR +Y + A +D + NKN
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
A L K + + + AI ++ +A+K D Y G+ Y E+ N A + F K
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKC 1044
Query: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVAMGQF 348
+ + L RG+ + + A+++F L ++ N QY+ + + + +F
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKF 1104
Query: 349 YEGIKAQTKVMLNDPLPGQKA 369
A+ L++ P Q+A
Sbjct: 1105 TIYQIAEMDKGLSELSPMQQA 1125
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 16/227 (7%)
Query: 123 SQAKSIAEQKRFPFATDNDSTN----EELAIAYVLIGSGLYD----EAIRHFSTMLQILS 174
+Q K F A D D N E A+ + +G+ A ST + L+
Sbjct: 1387 AQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT 1446
Query: 175 PLGRINE-------AVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLELN 226
G I+E A+ D AI L P L Y + G +YF ++ A + F ++L+ +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 227 KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 286
++ + +T +EA E F ++ + Y + Y L +E A E
Sbjct: 1507 PENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEED 1566
Query: 287 FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
KAL L N R + G ++EA+ ++ + L LE Y V
Sbjct: 1567 LNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASV 1613
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 7/172 (4%)
Query: 185 DLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRG 244
D T+ ++L + +RG +Y Y A EDF+Q+ +++ +
Sbjct: 1263 DATETVKLNT----FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRIN 1318
Query: 245 LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQTL 301
+EA+ F ALK F+DAY G +Y E G+ EA A + F KAL +N +++
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 302 QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 353
G L G Q+A +F + +P N + + + + MG + ++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 14/245 (5%)
Query: 154 IGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 213
+ S L E I+++ + ++IL+ E +ND TK A Y RG +Y
Sbjct: 886 VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934
Query: 214 TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 273
+A D Q+ + L A ++ L + + + EA++ K + +AY S +
Sbjct: 935 SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994
Query: 274 YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
YR + A ++ +A+ RG M Y + A+ +F +C+ +P
Sbjct: 995 YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053
Query: 334 CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 391
+GL + ++ I+ T ++ D Q L +KY L +++ Y A +D
Sbjct: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113
Query: 392 TPLTE 396
L+E
Sbjct: 1114 KGLSE 1118
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 19/245 (7%)
Query: 137 ATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLG-----------RINE---A 182
AT+ N L + + G Y A+ F I G RINE A
Sbjct: 1264 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEA 1323
Query: 183 VNDLTKAIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGL 238
VN T A+++ P Y RG Y D AT A +DF ++L +N A + G
Sbjct: 1324 VNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
Query: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298
+G ++A F A+ AY+ ++GN AA + A+ ++
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-A 1442
Query: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
+ L RG++ G Q A+K+++ + L P + + G + QF + +K
Sbjct: 1443 EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKA 1502
Query: 359 MLNDP 363
+ DP
Sbjct: 1503 LKFDP 1507
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 4/201 (1%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
I LG++ A+NDL + I L+P Y HR +Y + A +D + NKN
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
A L K + + + AI ++ +A+K D Y G+ Y E+ N A + F K
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKC 1044
Query: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVAMGQF 348
+ + L RG+ + + A+++F L ++ N QY+ + + + +F
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKF 1104
Query: 349 YEGIKAQTKVMLNDPLPGQKA 369
A+ L++ P Q+A
Sbjct: 1105 TIYQIAEMDKGLSELSPMQQA 1125
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 16/227 (7%)
Query: 123 SQAKSIAEQKRFPFATDNDSTN----EELAIAYVLIGSGLYD----EAIRHFSTMLQILS 174
+Q K F A D D N E A+ + +G+ A ST + L+
Sbjct: 1387 AQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT 1446
Query: 175 PLGRINE-------AVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLELN 226
G I+E A+ D AI L P L Y + G +YF ++ A + F ++L+ +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 227 KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 286
++ + +T +EA E F ++ + Y + Y L +E A E
Sbjct: 1507 PENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEED 1566
Query: 287 FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
KAL L N R + G ++EA+ ++ + L LE Y V
Sbjct: 1567 LNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASV 1613
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 7/172 (4%)
Query: 185 DLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRG 244
D T+ ++L + +RG +Y Y A EDF+Q+ +++ +
Sbjct: 1263 DATETVKLNT----FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRIN 1318
Query: 245 LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQTL 301
+EA+ F ALK F+DAY G +Y E G+ EA A + F KAL +N +++
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 302 QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 353
G L G Q+A +F + +P N + + + + MG + ++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 14/245 (5%)
Query: 154 IGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 213
+ S L E I+++ + ++IL+ E +ND TK A Y RG +Y
Sbjct: 886 VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934
Query: 214 TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 273
+A D Q+ + L A ++ L + + + EA++ K + +AY S +
Sbjct: 935 SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994
Query: 274 YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
YR + A ++ +A+ RG M Y + A+ +F +C+ +P
Sbjct: 995 YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053
Query: 334 CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 391
+GL + ++ I+ T ++ D Q L +KY L +++ Y A +D
Sbjct: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113
Query: 392 TPLTE 396
L+E
Sbjct: 1114 KGLSE 1118
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 19/245 (7%)
Query: 137 ATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLG-----------RINE---A 182
AT+ N L + + G Y A+ F I G RINE A
Sbjct: 1264 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEA 1323
Query: 183 VNDLTKAIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGL 238
VN T A+++ P Y RG Y D AT A +DF ++L +N A + G
Sbjct: 1324 VNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
Query: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298
+G ++A F A+ AY+ ++GN AA + A+ ++
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-A 1442
Query: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
+ L RG++ G Q A+K+++ + L P + + G + QF + +K
Sbjct: 1443 EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKA 1502
Query: 359 MLNDP 363
+ DP
Sbjct: 1503 LKFDP 1507
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 60.1 bits (144), Expect = 8e-09
Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 4/201 (1%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
I LG++ A+NDL + I L+P Y HR +Y + A +D + NKN
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
A L K + + + AI ++ +A+K D Y G+ Y E+ N A + F K
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKC 1044
Query: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVAMGQF 348
+ + L RG+ + + A+++F L ++ N QY+ + + + +F
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKF 1104
Query: 349 YEGIKAQTKVMLNDPLPGQKA 369
A+ L++ P Q+A
Sbjct: 1105 TIYQIAEMDKGLSELSPMQQA 1125
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 16/227 (7%)
Query: 123 SQAKSIAEQKRFPFATDNDSTN----EELAIAYVLIGSGLYD----EAIRHFSTMLQILS 174
+Q K F A D D N E A+ + +G+ A ST + L+
Sbjct: 1387 AQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT 1446
Query: 175 PLGRINE-------AVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLELN 226
G I+E A+ D AI L P L Y + G +YF ++ A + F ++L+ +
Sbjct: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
Query: 227 KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 286
++ + +T +EA E F ++ + Y + Y L +E A E
Sbjct: 1507 PENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEED 1566
Query: 287 FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
KAL L N R + G ++EA+ ++ + L LE Y V
Sbjct: 1567 LNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASV 1613
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 7/172 (4%)
Query: 185 DLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRG 244
D T+ ++L + +RG +Y Y A EDF+Q+ +++ +
Sbjct: 1263 DATETVKLNT----FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRIN 1318
Query: 245 LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQTL 301
+EA+ F ALK F+DAY G +Y E G+ EA A + F KAL +N +++
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 302 QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 353
G L G Q+A +F + +P N + + + + MG + ++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 14/245 (5%)
Query: 154 IGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 213
+ S L E I+++ + ++IL+ E +ND TK A Y RG +Y
Sbjct: 886 VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934
Query: 214 TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 273
+A D Q+ + L A ++ L + + + EA++ K + +AY S +
Sbjct: 935 SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994
Query: 274 YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333
YR + A ++ +A+ RG M Y + A+ +F +C+ +P
Sbjct: 995 YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053
Query: 334 CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 391
+GL + ++ I+ T ++ D Q L +KY L +++ Y A +D
Sbjct: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113
Query: 392 TPLTE 396
L+E
Sbjct: 1114 KGLSE 1118
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 19/245 (7%)
Query: 137 ATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLG-----------RINE---A 182
AT+ N L + + G Y A+ F I G RINE A
Sbjct: 1264 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEA 1323
Query: 183 VNDLTKAIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGL 238
VN T A+++ P Y RG Y D AT A +DF ++L +N A + G
Sbjct: 1324 VNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
Query: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298
+G ++A F A+ AY+ ++GN AA + A+ ++
Sbjct: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-A 1442
Query: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
+ L RG++ G Q A+K+++ + L P + + G + QF + +K
Sbjct: 1443 EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKA 1502
Query: 359 MLNDP 363
+ DP
Sbjct: 1503 LKFDP 1507
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 59.3 bits (142), Expect = 1e-08
Identities = 56/250 (22%), Positives = 108/250 (43%), Gaps = 30/250 (12%)
Query: 123 SQAKSIAEQKRFPFATD---------NDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQIL 173
S A +AEQ+RF A + DS++ L+ +GL ++A+ H+ ++ L
Sbjct: 479 SLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK-L 537
Query: 174 SP--------LGRINEAVNDLT-------KAIQLQPSARLYRHRGTLYFISEDYATAHED 218
SP LGR+ ++ + + +A+Q+ A + G LY+ + Y A +
Sbjct: 538 SPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQI 597
Query: 219 FQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELG 278
+Q++ L +Q L G KEA + + ++ ++ Y+ L Y +
Sbjct: 598 YQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQE 657
Query: 279 NFEAATESFQKALLLNQNHVQTLQ----LRGMMLYHHGSLQEALKNFKRCLQLEP-YNEV 333
N + A ++ KAL L + + +G L L +A ++++ +QL P +
Sbjct: 658 NHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQA 717
Query: 334 CQYMKGLSHV 343
M G+ H+
Sbjct: 718 WMNMGGIQHI 727
Score = 57.8 bits (138), Expect = 4e-08
Identities = 98/439 (22%), Positives = 175/439 (39%), Gaps = 72/439 (16%)
Query: 173 LSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPI 231
L GR EA+ A++L P A + GTL + D A A +Q++L+L+
Sbjct: 385 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNR 441
Query: 232 AMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKAL 291
A+ G + +EAI K+++K +F DAY SL E F+ A E +Q +
Sbjct: 442 ALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGI 501
Query: 292 LLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEG 351
+ G+ L G ++A+ ++++ ++L P + V V +G+ Y
Sbjct: 502 KNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAM-------VNLGRLYRS 554
Query: 352 IKAQTKVMLNDPLPGQKASPEYLKVKYLREYSRYLH-AHLDTPLTEYNIDVDLPGSFKDH 410
+ G+ + E Y R L AH L+ G +++
Sbjct: 555 L-------------GENSMAE-------EWYKRALQVAHKAEILSPLGALYYNTGRYEE- 593
Query: 411 WAKNLPFLIEDYEEQPGLQPH-------IKDVLHQNFESYKPEVQELICVADRLGSLMQY 463
++ Y+E LQP + VL ++ + E V++ G L Y
Sbjct: 594 -------ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECY 646
Query: 464 ETPGFLPNKRIHRAMGLAALEVMQAVQRTWTNSKVRMN---GKTRLMQWRDMFDIAVKWR 520
+ +K+ + L A++ +A+Q + KV K ++ +++ D A +
Sbjct: 647 RLLSAIYSKQENHDKALDAID--KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESY 704
Query: 521 RIA---DPDQPVLWLDQMPARSLSRGFNNHINLIRGQVINMRYLEYFEKILHFIKDRILV 577
R+A +PDQ W++ I I+G+ ++ R Y+E+ L + D L+
Sbjct: 705 RVAVQLNPDQAQAWMNM-----------GGIQHIKGKYVSAR--AYYERALQLVPDSKLL 751
Query: 578 YHGANN----PKGLLEVRE 592
K L EVRE
Sbjct: 752 KENLAKLDRLEKRLQEVRE 770
Score = 50.1 bits (118), Expect = 8e-06
Identities = 46/203 (22%), Positives = 86/203 (42%), Gaps = 2/203 (0%)
Query: 158 LYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAH 216
L+ + R + +L + EA+ L +I+ P A Y +L E + A
Sbjct: 435 LHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAE 494
Query: 217 EDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRE 276
E +Q ++ + G+ GL ++A+ +++A+K A +LG+ YR
Sbjct: 495 EIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRS 554
Query: 277 LGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
LG A E +++AL + + + L G + Y+ G +EAL+ ++ L+P +
Sbjct: 555 LGENSMAEEWYKRALQV-AHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRL 613
Query: 337 MKGLSHVAMGQFYEGIKAQTKVM 359
MGQ E K ++
Sbjct: 614 ALAQVLAVMGQTKEAEKMTNHIV 636
>gi|195963398 suppressor of G2 allele of SKP1 isoform a [Homo
sapiens]
Length = 365
Score = 57.0 bits (136), Expect = 7e-08
Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 3/97 (3%)
Query: 182 AVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
A+ +LTKA++ +P A+ Y R + + +Y A D ++SLELN N AML KG+
Sbjct: 30 ALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICE 89
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYREL 277
+H A+E+F E QK+D + +GQA +L
Sbjct: 90 YHEKNYAAALETFTEG--QKLDIETGFHRVGQAGLQL 124
Score = 40.0 bits (92), Expect = 0.009
Identities = 24/80 (30%), Positives = 39/80 (48%)
Query: 249 AIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMML 308
A+E +AL+QK D Y + LGN+ A +K+L LN N+ + +G+
Sbjct: 30 ALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICE 89
Query: 309 YHHGSLQEALKNFKRCLQLE 328
YH + AL+ F +L+
Sbjct: 90 YHEKNYAAALETFTEGQKLD 109
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 57.0 bits (136), Expect = 7e-08
Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 28/245 (11%)
Query: 136 FATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSP------LGRINEAVNDLTKA 189
+A D ++A ++ + Y + + + + QIL L A L +
Sbjct: 385 YAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEK 444
Query: 190 IQLQPSARLYRHRGTLYF-------------ISEDYATAH----EDFQQSLELNKNQPIA 232
+Q + + G L+F S D A A E + ++ + + +A
Sbjct: 445 VQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLA 504
Query: 233 MLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALL 292
LY+ + FH EA + +K L++ +++D Y LG R+ GNF A++ F++AL
Sbjct: 505 RLYEAMCEFH-----EAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQ 559
Query: 293 LNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGI 352
+NQ+H L G + K F+R L+ M L +V + ++
Sbjct: 560 INQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPT 619
Query: 353 KAQTK 357
+ + K
Sbjct: 620 RDREK 624
Score = 35.0 bits (79), Expect = 0.28
Identities = 22/102 (21%), Positives = 41/102 (40%), Gaps = 2/102 (1%)
Query: 237 GLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQN 296
G H+G +EA + F + + D D + +L Y E + +A + ++ L
Sbjct: 654 GAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYK 713
Query: 297 HVQT--LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
H T + L+ G LQE + + + P + V +
Sbjct: 714 HQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMF 755
Score = 33.5 bits (75), Expect = 0.81
Identities = 29/134 (21%), Positives = 58/134 (43%), Gaps = 5/134 (3%)
Query: 179 INEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHE---DFQQSLELNKNQPIAML 234
I V L++A + PS + H +F +DY+ + E+ Q +
Sbjct: 251 IKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCY 310
Query: 235 YKGLTFFHRGLLKEAIESFKEALK-QKVDFIDAYKSLGQAYRELGNFEAATESFQKALLL 293
+F + +A + + +A + F+ + LGQ Y G+ E A++ F+K L
Sbjct: 311 QLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKA 370
Query: 294 NQNHVQTLQLRGMM 307
N+ +T+++ G +
Sbjct: 371 YPNNYETMKILGSL 384
>gi|27262638 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 55.1 bits (131), Expect = 3e-07
Identities = 35/113 (30%), Positives = 58/113 (51%)
Query: 177 GRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYK 236
G EAV T++I P+ Y +R +++ +A +D ++ LEL A+L +
Sbjct: 223 GDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRR 282
Query: 237 GLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQK 289
T+ H+ L+EA E + L + D A K+L + R+L N EAA+E+ K
Sbjct: 283 ATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTK 335
Score = 37.4 bits (85), Expect = 0.056
Identities = 47/244 (19%), Positives = 91/244 (37%), Gaps = 35/244 (14%)
Query: 155 GSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYA 213
GS + D+ +S G + + D +A++L P S + R Y E Y
Sbjct: 479 GSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYG 538
Query: 214 TAHEDFQQSLEL-----------NKNQPIAMLYKGLTFFHR---------GLLKEAIESF 253
A+ D++ L++ N+ I M G + + + +A
Sbjct: 539 KAYVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPA 598
Query: 254 KEALKQKVDFIDAYKSLG-------QAYRELGN-------FEAATESFQKALLLNQNHVQ 299
KE + ++ +++ G +A +E GN ++ A + + L +N
Sbjct: 599 KEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECA 658
Query: 300 TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVM 359
R + +EA ++ + LQL N Y + L+H + + + + KV+
Sbjct: 659 IYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVI 718
Query: 360 LNDP 363
L DP
Sbjct: 719 LLDP 722
Score = 34.7 bits (78), Expect = 0.36
Identities = 79/357 (22%), Positives = 126/357 (35%), Gaps = 47/357 (13%)
Query: 14 GGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEH-YSPLSLLKQELQHRQQQEAPAGGG 72
G A AA + L G G RP A + +P + + R A AGGG
Sbjct: 372 GAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGG 431
Query: 73 GCSPQSGDWGDQYSAEC---GESSFLNFHDSDC-----------EPKGSSPCDSLLSLNT 118
G G + A G F + ++ EP GS D L L +
Sbjct: 432 ATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYS 491
Query: 119 EKILSQAKS------IAEQKR----FPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFST 168
+ K I + R PF+ A+AY + Y +A + T
Sbjct: 492 NRAACYLKEGNCSGCIQDCNRALELHPFSM---KPLLRRAMAYETLEQ--YGKAYVDYKT 546
Query: 169 MLQILSPLGRINEAVNDLTKAI----------QLQP------SARLYRHRGTLYFISEDY 212
+LQI L N++VN L++ + +L P S L IS+
Sbjct: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606
Query: 213 ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 272
+ QQ + K A+ +G + K+A+ + E LK Y +
Sbjct: 607 GDSSSHRQQGITDEKTFK-ALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRAL 665
Query: 273 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEP 329
Y +L FE A + +AL L +V+ R + + Q++L + + + L+P
Sbjct: 666 CYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
>gi|27262636 sperm associated antigen 1 [Homo sapiens]
Length = 926
Score = 55.1 bits (131), Expect = 3e-07
Identities = 35/113 (30%), Positives = 58/113 (51%)
Query: 177 GRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYK 236
G EAV T++I P+ Y +R +++ +A +D ++ LEL A+L +
Sbjct: 223 GDYEEAVMYYTRSISALPTVVAYNNRAQAEIKLQNWNSAFQDCEKVLELEPGNVKALLRR 282
Query: 237 GLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQK 289
T+ H+ L+EA E + L + D A K+L + R+L N EAA+E+ K
Sbjct: 283 ATTYKHQNKLREATEDLSKVLDVEPDNDLAKKTLSEVERDLKNSEAASETQTK 335
Score = 37.4 bits (85), Expect = 0.056
Identities = 47/244 (19%), Positives = 91/244 (37%), Gaps = 35/244 (14%)
Query: 155 GSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYA 213
GS + D+ +S G + + D +A++L P S + R Y E Y
Sbjct: 479 GSEIADDLSILYSNRAACYLKEGNCSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYG 538
Query: 214 TAHEDFQQSLEL-----------NKNQPIAMLYKGLTFFHR---------GLLKEAIESF 253
A+ D++ L++ N+ I M G + + + +A
Sbjct: 539 KAYVDYKTVLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPA 598
Query: 254 KEALKQKVDFIDAYKSLG-------QAYRELGN-------FEAATESFQKALLLNQNHVQ 299
KE + ++ +++ G +A +E GN ++ A + + L +N
Sbjct: 599 KEMISKQAGDSSSHRQQGITDEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECA 658
Query: 300 TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVM 359
R + +EA ++ + LQL N Y + L+H + + + + KV+
Sbjct: 659 IYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVI 718
Query: 360 LNDP 363
L DP
Sbjct: 719 LLDP 722
Score = 34.7 bits (78), Expect = 0.36
Identities = 79/357 (22%), Positives = 126/357 (35%), Gaps = 47/357 (13%)
Query: 14 GGAVAAAGAARRVLLLLLLGVLSAGLRPGALATEH-YSPLSLLKQELQHRQQQEAPAGGG 72
G A AA + L G G RP A + +P + + R A AGGG
Sbjct: 372 GAARAAQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGG 431
Query: 73 GCSPQSGDWGDQYSAEC---GESSFLNFHDSDC-----------EPKGSSPCDSLLSLNT 118
G G + A G F + ++ EP GS D L L +
Sbjct: 432 ATGHPGGGQGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYS 491
Query: 119 EKILSQAKS------IAEQKR----FPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFST 168
+ K I + R PF+ A+AY + Y +A + T
Sbjct: 492 NRAACYLKEGNCSGCIQDCNRALELHPFSM---KPLLRRAMAYETLEQ--YGKAYVDYKT 546
Query: 169 MLQILSPLGRINEAVNDLTKAI----------QLQP------SARLYRHRGTLYFISEDY 212
+LQI L N++VN L++ + +L P S L IS+
Sbjct: 547 VLQIDCGLQLANDSVNRLSRILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQA 606
Query: 213 ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 272
+ QQ + K A+ +G + K+A+ + E LK Y +
Sbjct: 607 GDSSSHRQQGITDEKTFK-ALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRAL 665
Query: 273 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEP 329
Y +L FE A + +AL L +V+ R + + Q++L + + + L+P
Sbjct: 666 CYLKLCQFEEAKQDCDQALQLADGNVKAFYRRALAHKGLKNYQKSLIDLNKVILLDP 722
>gi|5730041 suppressor of G2 allele of SKP1 isoform b [Homo sapiens]
Length = 333
Score = 54.3 bits (129), Expect = 4e-07
Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 182 AVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
A+ +LTKA++ +P A+ Y R + + +Y A D ++SLELN N AML KG+
Sbjct: 30 ALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICE 89
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDA 266
+H A+E+F E QK+D DA
Sbjct: 90 YHEKNYAAALETFTEG--QKLDSADA 113
Score = 40.0 bits (92), Expect = 0.009
Identities = 24/80 (30%), Positives = 39/80 (48%)
Query: 249 AIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMML 308
A+E +AL+QK D Y + LGN+ A +K+L LN N+ + +G+
Sbjct: 30 ALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICE 89
Query: 309 YHHGSLQEALKNFKRCLQLE 328
YH + AL+ F +L+
Sbjct: 90 YHEKNYAAALETFTEGQKLD 109
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 54.3 bits (129), Expect = 4e-07
Identities = 69/329 (20%), Positives = 122/329 (37%), Gaps = 55/329 (16%)
Query: 176 LGRINEAVNDLTKAIQL-QPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAML 234
LG+ A+ +A +L Q + + G Y + + A + +L LN++ + +
Sbjct: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHD-LTYI 172
Query: 235 YKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLN 294
G G L +AIE +K+A++ + + +LG Y +LG ++ A E AL +
Sbjct: 173 MLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYD 232
Query: 295 QNHVQTLQLRGMMLYHHGSLQEALKNF--------------------------------- 321
+ + + G M+ HG AL +
Sbjct: 233 PTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISC 292
Query: 322 -KRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKYL- 379
KR L P++ Y GL H+ M Q+ + + P G+ + + L
Sbjct: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLE 352
Query: 380 ------REYSRYLHAHLDTPLTEYNIDVDLPGSFKDHWAKNLPFLIEDYEEQPGLQPHIK 433
R Y+ +H PL N V L + KN + Y+E +K
Sbjct: 353 DIENAKRAYAEAVHLDKCNPLVNLNYAVLL---YNQGEKKN---ALAQYQEMEKKVSLLK 406
Query: 434 DVLHQNFESYKPEVQELICVADRLGSLMQ 462
D F+S E++ +A +LG+ +Q
Sbjct: 407 DNSSLEFDS------EMVEMAQKLGAALQ 429
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 1/125 (0%)
Query: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298
+ F G K AIE + EA K + +LG Y L F A + AL LN++ +
Sbjct: 110 SLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL 169
Query: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
+ L G + G L +A++ +K+ ++ P N GL ++ +G + + +
Sbjct: 170 TYIML-GKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNA 228
Query: 359 MLNDP 363
+ DP
Sbjct: 229 LTYDP 233
Score = 33.9 bits (76), Expect = 0.62
Identities = 32/156 (20%), Positives = 64/156 (41%), Gaps = 2/156 (1%)
Query: 177 GRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235
G I E++ L P SA + F+ + A E + ++ +LN+
Sbjct: 81 GNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
Query: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 295
G+ + + +A + AL + Y LG+ + G+ + A E ++KA+ +
Sbjct: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSP 199
Query: 296 NHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYN 331
+ + L G++ G Q+A ++ L +P N
Sbjct: 200 ENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTN 235
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 53.5 bits (127), Expect = 8e-07
Identities = 45/183 (24%), Positives = 81/183 (44%), Gaps = 16/183 (8%)
Query: 161 EAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQ 220
E + +ST L L ++ DLT + P A + G + + ++ A + FQ
Sbjct: 540 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEA--WCAAGNCFSLQREHDIAIKFFQ 597
Query: 221 QSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 280
++++++ N A G F L +A+ F+ A++ +A+ LG Y + F
Sbjct: 598 RAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 657
Query: 281 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ-------LEPYNEV 333
A FQKAL +N ++L H G +Q ALK ++ L ++P N +
Sbjct: 658 SLAEMHFQKALDINPQ-------SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 710
Query: 334 CQY 336
C++
Sbjct: 711 CKF 713
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/199 (19%), Positives = 82/199 (41%), Gaps = 1/199 (0%)
Query: 182 AVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
A+ +AIQ+ P+ A Y G + ++E+ A F+ ++ +N A G+ +
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 651
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300
+ + A F++AL +G L E A ++ KA++++ +
Sbjct: 652 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 711
Query: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360
R +L+ + + AL+ + Q+ P + ++ G + +GQ + + + M
Sbjct: 712 KFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMD 771
Query: 361 NDPLPGQKASPEYLKVKYL 379
DP E + +YL
Sbjct: 772 LDPKGANNQIKEAIDKRYL 790
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 53.5 bits (127), Expect = 8e-07
Identities = 45/183 (24%), Positives = 81/183 (44%), Gaps = 16/183 (8%)
Query: 161 EAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQ 220
E + +ST L L ++ DLT + P A + G + + ++ A + FQ
Sbjct: 534 EGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEA--WCAAGNCFSLQREHDIAIKFFQ 591
Query: 221 QSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 280
++++++ N A G F L +A+ F+ A++ +A+ LG Y + F
Sbjct: 592 RAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKF 651
Query: 281 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQ-------LEPYNEV 333
A FQKAL +N ++L H G +Q ALK ++ L ++P N +
Sbjct: 652 SLAEMHFQKALDINPQ-------SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704
Query: 334 CQY 336
C++
Sbjct: 705 CKF 707
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/199 (19%), Positives = 82/199 (41%), Gaps = 1/199 (0%)
Query: 182 AVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
A+ +AIQ+ P+ A Y G + ++E+ A F+ ++ +N A G+ +
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300
+ + A F++AL +G L E A ++ KA++++ +
Sbjct: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 705
Query: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360
R +L+ + + AL+ + Q+ P + ++ G + +GQ + + + M
Sbjct: 706 KFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMD 765
Query: 361 NDPLPGQKASPEYLKVKYL 379
DP E + +YL
Sbjct: 766 LDPKGANNQIKEAIDKRYL 784
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 50.8 bits (120), Expect = 5e-06
Identities = 30/122 (24%), Positives = 60/122 (49%), Gaps = 7/122 (5%)
Query: 205 LYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFI 264
LY++ +D+A A ++ ++ P A+ KG T F G ++A E +KEAL+
Sbjct: 468 LYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 527
Query: 265 DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
+A ++G Y +L + A + F K + +N + +LY ++ E ++N +
Sbjct: 528 EALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQA 580
Query: 325 LQ 326
++
Sbjct: 581 IE 582
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 8/184 (4%)
Query: 159 YDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQ--------LQPSARLYRHRGTLYFISE 210
Y EA+R+ S+ + L +G E +N L +A+ L+ SA + +Y + E
Sbjct: 516 YKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELME 575
Query: 211 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 270
+ + A E Q + + P + G + G +A + + E+ + I+ + L
Sbjct: 576 NPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWL 635
Query: 271 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
G Y + +E A + F++A L+ V+ + G+ Q+AL +K + P
Sbjct: 636 GAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPE 695
Query: 331 NEVC 334
N C
Sbjct: 696 NVEC 699
Score = 32.7 bits (73), Expect = 1.4
Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 1/138 (0%)
Query: 201 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 260
++G F + DY A E ++++L + + A+ GLT+ L EA++ F +
Sbjct: 498 NKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAIL 557
Query: 261 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 320
+ + + Y + N A E + + + Q L G + G +A +
Sbjct: 558 RNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQY 617
Query: 321 FKRCLQLEPYN-EVCQYM 337
+ + P N EV +++
Sbjct: 618 YYESYRYFPCNIEVIEWL 635
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 50.8 bits (120), Expect = 5e-06
Identities = 30/122 (24%), Positives = 60/122 (49%), Gaps = 7/122 (5%)
Query: 205 LYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFI 264
LY++ +D+A A ++ ++ P A+ KG T F G ++A E +KEAL+
Sbjct: 459 LYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCT 518
Query: 265 DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
+A ++G Y +L + A + F K + +N + +LY ++ E ++N +
Sbjct: 519 EALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAE-------VLYQIANIYELMENPSQA 571
Query: 325 LQ 326
++
Sbjct: 572 IE 573
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 8/184 (4%)
Query: 159 YDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQ--------LQPSARLYRHRGTLYFISE 210
Y EA+R+ S+ + L +G E +N L +A+ L+ SA + +Y + E
Sbjct: 507 YKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELME 566
Query: 211 DYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSL 270
+ + A E Q + + P + G + G +A + + E+ + I+ + L
Sbjct: 567 NPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWL 626
Query: 271 GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 330
G Y + +E A + F++A L+ V+ + G+ Q+AL +K + P
Sbjct: 627 GAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPE 686
Query: 331 NEVC 334
N C
Sbjct: 687 NVEC 690
Score = 32.7 bits (73), Expect = 1.4
Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 1/138 (0%)
Query: 201 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 260
++G F + DY A E ++++L + + A+ GLT+ L EA++ F +
Sbjct: 489 NKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAIL 548
Query: 261 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 320
+ + + Y + N A E + + + Q L G + G +A +
Sbjct: 549 RNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQY 608
Query: 321 FKRCLQLEPYN-EVCQYM 337
+ + P N EV +++
Sbjct: 609 YYESYRYFPCNIEVIEWL 626
>gi|116534937 interferon-induced protein with tetratricopeptide
repeats 1 isoform 2 [Homo sapiens]
Length = 478
Score = 50.4 bits (119), Expect = 6e-06
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 22/164 (13%)
Query: 177 GRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYK 236
G +++A+ L KA+Q P++ L H+ L + ++ Q E K QP +
Sbjct: 265 GSVDKALELLKKALQETPTSVLLHHQIGLCYKAQ--------MIQIKEATKGQPRGQNRE 316
Query: 237 GLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQN 296
L +++ AI F+ A+++K F A+ L + Y E GN A E+FQK L +
Sbjct: 317 KLD----KMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPV 372
Query: 297 HVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGL 340
+T+Q + +H+G QE K N + Y+K +
Sbjct: 373 VEETMQ---DIHFHYGRFQEFQKK-------SDVNAIIHYLKAI 406
>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
sapiens]
Length = 631
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/200 (21%), Positives = 92/200 (46%), Gaps = 14/200 (7%)
Query: 177 GRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235
G+ +EA++ TK + P + L +R + YF + +A A D ++ LN++ A
Sbjct: 147 GKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSR 206
Query: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFE-----------AAT 284
+G F L+EA + ++ L+ + + +A L + + L + E +T
Sbjct: 207 RGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKST 266
Query: 285 ESFQKALLLNQNHVQTL--QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSH 342
E +K + QN Q + + RG + G + A++ + R + + N + + +++
Sbjct: 267 EGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAY 326
Query: 343 VAMGQFYEGIKAQTKVMLND 362
+ + ++ E K T+ +L D
Sbjct: 327 LKIQKYEEAEKDCTQAILLD 346
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/127 (24%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKS 269
E + E + + ++ + + + KG +F +G EAI+ + + + D Y
Sbjct: 113 ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDA-----DPYNP 167
Query: 270 L-----GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
+ AY L F A A+ LN+++ + RG + L+EA K+++R
Sbjct: 168 VLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERV 227
Query: 325 LQLEPYN 331
L+LEP N
Sbjct: 228 LELEPNN 234
>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
sapiens]
Length = 665
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/200 (21%), Positives = 92/200 (46%), Gaps = 14/200 (7%)
Query: 177 GRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLY 235
G+ +EA++ TK + P + L +R + YF + +A A D ++ LN++ A
Sbjct: 147 GKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSR 206
Query: 236 KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFE-----------AAT 284
+G F L+EA + ++ L+ + + +A L + + L + E +T
Sbjct: 207 RGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKST 266
Query: 285 ESFQKALLLNQNHVQTL--QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSH 342
E +K + QN Q + + RG + G + A++ + R + + N + + +++
Sbjct: 267 EGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAY 326
Query: 343 VAMGQFYEGIKAQTKVMLND 362
+ + ++ E K T+ +L D
Sbjct: 327 LKIQKYEEAEKDCTQAILLD 346
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/127 (24%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKS 269
E + E + + ++ + + + KG +F +G EAI+ + + + D Y
Sbjct: 113 ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDA-----DPYNP 167
Query: 270 L-----GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRC 324
+ AY L F A A+ LN+++ + RG + L+EA K+++R
Sbjct: 168 VLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERV 227
Query: 325 LQLEPYN 331
L+LEP N
Sbjct: 228 LELEPNN 234
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 47.8 bits (112), Expect = 4e-05
Identities = 25/107 (23%), Positives = 52/107 (48%)
Query: 196 ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKE 255
A ++ +G Y+ +DY A+ + +++++ + T G +EA+ ++
Sbjct: 28 AETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQ 87
Query: 256 ALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQ 302
+++ F+ + G+ + LGN AA SFQ+AL L+ + Q Q
Sbjct: 88 SVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQ 134
Score = 45.4 bits (106), Expect = 2e-04
Identities = 56/262 (21%), Positives = 109/262 (41%), Gaps = 37/262 (14%)
Query: 107 SSPCDSLLSLNTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAI--- 163
++ CD +++ ++L ++ E + F + ++ AY Y +AI
Sbjct: 4 AAECDVVMAATEPELLDDQEAKREAETFKEQGNAYYAKKDYNEAY-----NYYTKAIDMC 58
Query: 164 ----RHFSTMLQILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHED 218
++ L LGR EA+ D ++++L S R + G + + A
Sbjct: 59 PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 118
Query: 219 FQQSLELN----------KNQPIAMLYKGL--TFFHRGLLKEAIESFKEALKQKVDFIDA 266
FQ++LEL+ KN M Y+ + T F + ++ + AL +F A
Sbjct: 119 FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRAL----EFAPA 174
Query: 267 ---YKSL-GQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFK 322
+K L + LG + A L ++ + L +RG+ LY+ +++A++ F
Sbjct: 175 CHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFV 234
Query: 323 RCLQLEPYNE----VCQYMKGL 340
+ L++ P +E C+ K L
Sbjct: 235 QALRMAPDHEKACIACRNAKAL 256
Score = 34.7 bits (78), Expect = 0.36
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 17/99 (17%)
Query: 174 SPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIA 232
S L ++++A+ D T A++L + + Y R Y +E Y A D+++ + K +
Sbjct: 305 SKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKE-- 362
Query: 233 MLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLG 271
H+ LLK A +++ ++ D YK LG
Sbjct: 363 ---------HKQLLKNAQLELRKSKRK-----DYYKILG 387
Score = 32.7 bits (73), Expect = 1.4
Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 17/128 (13%)
Query: 179 INEAVNDLTKAIQLQP-------------SARLYRHRGTLYFISEDYATAHEDFQQSLEL 225
I +AV +A+++ P + + + G F +Y A+E + ++L +
Sbjct: 226 IEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGI 285
Query: 226 NKN--QPIAMLY--KGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFE 281
+ N + A LY +G L +AIE A+K +I AY Q Y + +E
Sbjct: 286 DPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYE 345
Query: 282 AATESFQK 289
A ++K
Sbjct: 346 EAVRDYEK 353
>gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens]
Length = 873
Score = 47.4 bits (111), Expect = 5e-05
Identities = 38/165 (23%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 172 ILSPLGRINEAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
IL+ G++ A+ + +AI+ P L+ RGT+Y +++ A EDF + L++
Sbjct: 260 ILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQ 319
Query: 231 IAMLYKG-----LTF-------FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELG 278
M+ + LT+ + +G +E + +AL+ + Y + G + +LG
Sbjct: 320 EDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLG 379
Query: 279 NFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKR 323
N A +Q+AL L+ G++ G ++ K F++
Sbjct: 380 NLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQK 424
Score = 39.7 bits (91), Expect = 0.011
Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 7/95 (7%)
Query: 249 AIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQ------ 302
A+ F AL +D Y +AY +L +F +A ++ ++A L Q++ + L+
Sbjct: 80 AVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLERLTFVL 139
Query: 303 -LRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
L+G L+ + +AL F +L+P +Y
Sbjct: 140 YLQGQCLFEQCAFLDALNVFSHAAELQPEKPCFRY 174
Score = 34.3 bits (77), Expect = 0.47
Identities = 39/150 (26%), Positives = 65/150 (43%), Gaps = 9/150 (6%)
Query: 177 GRINEAVNDLTKAIQLQPSAR-LYRHRGTLYFISEDYATAHEDFQQSLELN-----KNQP 230
G E V L KA++ + + LY +RG +F + A A D+QQ+L L+ N
Sbjct: 345 GAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEADYQQALALSPQDEGANTR 404
Query: 231 IAMLYKGLTFF--HRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQ 288
+ +L + + F R ++A F A++ Y ++ + L N A +
Sbjct: 405 MGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSRQLLQNIFGARQDVA 464
Query: 289 KALLLNQNHVQTLQLRGMMLYHHGSLQEAL 318
LLLN + L L L+ S++E L
Sbjct: 465 TVLLLNPKQPK-LSLLMTNLFPGMSVEEVL 493
Score = 30.4 bits (67), Expect = 6.8
Identities = 28/116 (24%), Positives = 40/116 (34%), Gaps = 13/116 (11%)
Query: 257 LKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMM--------- 307
LKQ D Y + Y L ALLLN H Q L M
Sbjct: 197 LKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQ 256
Query: 308 ----LYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVM 359
L G LQ AL+ R ++ P + +G + + +F ++ KV+
Sbjct: 257 DAGILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVL 312
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 47.0 bits (110), Expect = 7e-05
Identities = 27/91 (29%), Positives = 49/91 (53%)
Query: 246 LKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRG 305
L+EA + +++A+ + DF AY S G+ ++ A E++ KAL L++N+
Sbjct: 545 LEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLA 604
Query: 306 MMLYHHGSLQEALKNFKRCLQLEPYNEVCQY 336
++ EALKNF R L+L P +++ +
Sbjct: 605 IVHIELKEPNEALKNFNRALELNPKHKLALF 635
Score = 38.9 bits (89), Expect = 0.019
Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%)
Query: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGR 178
E +L K + ++ + A + D N +L Y+ AI H +++ P
Sbjct: 571 ELLLKMNKPLKAKEAYLKALELDRNNADL----------WYNLAIVH----IELKEP--- 613
Query: 179 INEAVNDLTKAIQLQPSARLYRHRGTLYFI-SEDYATAHEDFQQSLELNKNQPIAMLYKG 237
NEA+ + +A++L P +L + S + E ++ L +P+
Sbjct: 614 -NEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPL----DA 668
Query: 238 LTFFHRGLL-------KEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290
+F+ G+L EA K+A+K + DF A +L Y + A ++
Sbjct: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
Query: 291 LLLNQNHVQTLQLRG-MMLYHHGSLQEALKNFKRCLQLEPYN 331
L +H++ L L+G +++ + A K F+R L+++P N
Sbjct: 729 LRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSN 770
>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo
sapiens]
Length = 504
Score = 46.6 bits (109), Expect = 9e-05
Identities = 43/157 (27%), Positives = 68/157 (43%), Gaps = 4/157 (2%)
Query: 141 DSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYR 200
D T L ++L+ G DEA F +L+ EA + L K+ ++Q RL R
Sbjct: 103 DFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQ---RL-R 158
Query: 201 HRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQK 260
+ F S DY A + LE+ + F G ++AI K A K K
Sbjct: 159 SQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLK 218
Query: 261 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNH 297
D +A+ + Y +LG+ E + ++ L L+Q+H
Sbjct: 219 NDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDH 255
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/96 (20%), Positives = 41/96 (42%)
Query: 213 ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 272
A A F +++ + + IA + F G K A+ + ++ K+DF A G
Sbjct: 54 ADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGH 113
Query: 273 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMML 308
+ G + A + F+K L N + + + + ++
Sbjct: 114 LLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLI 149
Score = 31.2 bits (69), Expect = 4.0
Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 16/92 (17%)
Query: 181 EAVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLT 239
EA+ ++ +Q++P + + R Y I E Y A +D++ + E N+N
Sbjct: 324 EAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQ--------- 374
Query: 240 FFHRGLLKEAIESFKEALKQKVDFIDAYKSLG 271
++E +E + LKQ D YK LG
Sbjct: 375 -----QIREGLEKAQRLLKQS-QKRDYYKILG 400
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 46.6 bits (109), Expect = 9e-05
Identities = 37/187 (19%), Positives = 73/187 (39%), Gaps = 9/187 (4%)
Query: 182 AVNDLTKAIQLQP-SARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTF 240
+ D A + P +A +Y HRG L + + A DF + + L +A K
Sbjct: 386 STQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFAL 445
Query: 241 FHRGL-------LKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLL 293
+ + ++ A++ F+E +K+ + Y QA + F A E + K + L
Sbjct: 446 YRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDL 505
Query: 294 NQNHVQTLQLRGMM-LYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGI 352
++ T +G++ L L L+ + ++++ + G V G + I
Sbjct: 506 EPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAI 565
Query: 353 KAQTKVM 359
K +
Sbjct: 566 DMFNKAI 572
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/177 (21%), Positives = 70/177 (39%), Gaps = 12/177 (6%)
Query: 176 LGRINEAVNDLTKAIQLQPS-----ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230
+G N A DL K I L+ + A RG++Y + + +DF + +++
Sbjct: 342 IGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNA 401
Query: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVD--FIDAYKSLG---QAY--RELGNFEAA 283
++G ++EA+ F E ++ + + A K QAY +AA
Sbjct: 402 DVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAA 461
Query: 284 TESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGL 340
+ F++ + + L L +A + + +C+ LEP N KGL
Sbjct: 462 MKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGL 518
Score = 36.6 bits (83), Expect = 0.096
Identities = 27/113 (23%), Positives = 53/113 (46%), Gaps = 5/113 (4%)
Query: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFH-RGLLKEAIESFKEALK--QKVDFIDA 266
+ + A E + + ++L + ++KGL + L +E +A++ K DF A
Sbjct: 490 QQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDF--A 547
Query: 267 YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALK 319
Y+++G + GN E A + F KA+ L ++ ++ L + H + A K
Sbjct: 548 YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKK 600
>gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens]
Length = 151
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 3/126 (2%)
Query: 147 LAIAYVLIGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLY 206
L +A +G Y EA +S ++ + +E+ L A Y +RG +
Sbjct: 12 LTLAQAHFNNGEYAEAEALYSAYIRRCACAASSDESPGSKCSPEDL---ATAYNNRGQIK 68
Query: 207 FISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDA 266
+ D+ A +D+ ++E+ N + +GL + G +A+E FK+ L F DA
Sbjct: 69 YFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNPGFQDA 128
Query: 267 YKSLGQ 272
SL Q
Sbjct: 129 TLSLKQ 134
Score = 37.7 bits (86), Expect = 0.043
Identities = 21/68 (30%), Positives = 33/68 (48%)
Query: 262 DFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNF 321
D AY + GQ +F A + + A+ + N RG++LY G +AL++F
Sbjct: 56 DLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDF 115
Query: 322 KRCLQLEP 329
K+ L L P
Sbjct: 116 KKVLDLNP 123
Score = 31.2 bits (69), Expect = 4.0
Identities = 16/60 (26%), Positives = 31/60 (51%)
Query: 304 RGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDP 363
RG + Y EA+ ++ ++++P EV Y +GL +G F + ++ KV+ +P
Sbjct: 64 RGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNP 123
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/212 (25%), Positives = 87/212 (41%), Gaps = 29/212 (13%)
Query: 159 YDEAIRHFSTMLQILSPLG-------RINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISE 210
Y A+ + S M +L LG R EA++ AI +P+ A Y + G +
Sbjct: 516 YRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQG 575
Query: 211 DYATAHEDFQQSLEL----------NKNQPIAMLYK-GLTFFHRGLLKEAIESFKEAL-K 258
A F + E+ +K+ + LY G + +G +EA+ +KEA+ K
Sbjct: 576 RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
Query: 259 QKVDFI--DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 316
F Y +G+AY L A + ++L +H+ G +L G E
Sbjct: 636 MPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSE 695
Query: 317 ALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQF 348
A K F + ++L+P KG ++ GQF
Sbjct: 696 AEKLFLKAIELDP-------TKGNCYMHYGQF 720
Score = 35.0 bits (79), Expect = 0.28
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 3/129 (2%)
Query: 203 GTLYFISEDYATAHEDFQQSLELNKNQPIAM-LYK--GLTFFHRGLLKEAIESFKEALKQ 259
G LY Y A ++++++ Q LY G + L EA + E+L+
Sbjct: 613 GKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRS 672
Query: 260 KVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALK 319
K D I A+ + G+ G A + F KA+ L+ G L L EA +
Sbjct: 673 KTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAE 732
Query: 320 NFKRCLQLE 328
K+ +L+
Sbjct: 733 MAKKAAELD 741
Score = 32.7 bits (73), Expect = 1.4
Identities = 43/212 (20%), Positives = 78/212 (36%), Gaps = 29/212 (13%)
Query: 190 IQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEA 249
I++ P A+ + + G + + A ++ +L N + GL EA
Sbjct: 488 IKVNP-AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEA 546
Query: 250 IESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQ---------- 299
+ +K A+ + AY + G G E A +F K + +++
Sbjct: 547 LHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVT 606
Query: 300 -TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
L G + + G +EAL +K +Q P Q + + MG+ Y
Sbjct: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM----MGEAY--------- 653
Query: 359 MLNDPLPGQKASPEYLKVKYLREYSRYLHAHL 390
M LP E+ ++ LR + ++ AHL
Sbjct: 654 MRLSKLP----EAEHWYMESLRSKTDHIPAHL 681
>gi|24308141 small glutamine-rich tetratricopeptide repeat
(TPR)-containing, beta [Homo sapiens]
Length = 304
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 7/115 (6%)
Query: 180 NEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLT 239
N D+ KA QL + G + E+YA A + + Q++EL+ N + +
Sbjct: 76 NSVPEDVGKADQL-------KDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAA 128
Query: 240 FFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLN 294
G +AI+ ++A+ + AY +G A L FE A S+QKAL L+
Sbjct: 129 QSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLD 183
Score = 35.8 bits (81), Expect = 0.16
Identities = 29/143 (20%), Positives = 58/143 (40%)
Query: 241 FHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQT 300
F K + ++ + V D K G + + N+ AA + + +A+ L+ N+
Sbjct: 62 FTSSFCKNDVLPLSNSVPEDVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVY 121
Query: 301 LQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVML 360
R G +A+K+ ++ + ++ GL+ A+ +F E + + K +
Sbjct: 122 YCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALD 181
Query: 361 NDPLPGQKASPEYLKVKYLREYS 383
DP S + + LRE S
Sbjct: 182 LDPENDSYKSNLKIAEQKLREVS 204
>gi|4503729 FK506 binding protein 52 [Homo sapiens]
Length = 459
Score = 44.3 bits (103), Expect = 5e-04
Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 15/141 (10%)
Query: 210 EDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFK--------------- 254
+ + A E ++ + E Q + +G +F G K+A+ +K
Sbjct: 250 KSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNE 309
Query: 255 EALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSL 314
EA K + + ++ +L + +L F AA ES KAL L+ N+ + L RG
Sbjct: 310 EAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDF 369
Query: 315 QEALKNFKRCLQLEPYNEVCQ 335
+ A +F++ LQL P N+ +
Sbjct: 370 ELARADFQKVLQLYPNNKAAK 390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,919,129
Number of Sequences: 37866
Number of extensions: 1356489
Number of successful extensions: 4543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 4062
Number of HSP's gapped (non-prelim): 372
length of query: 807
length of database: 18,247,518
effective HSP length: 110
effective length of query: 697
effective length of database: 14,082,258
effective search space: 9815333826
effective search space used: 9815333826
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.