Guide to the Human Genome
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Search of human proteins with 17017980

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
         (720 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                    1478   0.0  
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                    1437   0.0  
gi|14780904 kelch-like 1 protein [Homo sapiens]                       932   0.0  
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     903   0.0  
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     903   0.0  
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     815   0.0  
gi|40807500 kelch-like 20 [Homo sapiens]                              459   e-129
gi|38194229 kelch-like 17 [Homo sapiens]                              444   e-124
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              405   e-113
gi|166235129 kelch-like 3 [Homo sapiens]                              401   e-111
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            399   e-111
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            399   e-111
gi|11056006 kelch-like 12 [Homo sapiens]                              395   e-110
gi|34101268 kelch-like 8 [Homo sapiens]                               395   e-110
gi|55925604 kelch-like 18 [Homo sapiens]                              395   e-110
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]            357   2e-98
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]        334   1e-91
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]        334   1e-91
gi|5174473 intracisternal A particle-promoted polypeptide isofor...   322   8e-88
gi|148664209 kelch-like 10 [Homo sapiens]                             322   1e-87
gi|223890235 intracisternal A particle-promoted polypeptide isof...   319   5e-87
gi|45643138 kelch-like 13 [Homo sapiens]                              266   5e-71
gi|40018614 DRE1 protein [Homo sapiens]                               265   8e-71
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    263   5e-70
gi|24308181 kelch-like 9 [Homo sapiens]                               261   1e-69
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                    257   2e-68
gi|24475847 influenza virus NS1A binding protein [Homo sapiens]       250   4e-66
gi|8922854 kelch-like 26 [Homo sapiens]                               246   5e-65
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]               245   1e-64
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo...   243   3e-64

>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score = 1478 bits (3826), Expect = 0.0
 Identities = 720/720 (100%), Positives = 720/720 (100%)

Query: 1   MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
           MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN
Sbjct: 1   MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60

Query: 61  GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
           GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC
Sbjct: 61  GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120

Query: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
           EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ
Sbjct: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180

Query: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
           LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240

Query: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
           YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300

Query: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
           NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR
Sbjct: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360

Query: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
           QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420

Query: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
           TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV
Sbjct: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480

Query: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
           VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV
Sbjct: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540

Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
           ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600

Query: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
           APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR
Sbjct: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660

Query: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESMQELLQNFYTTQKLKETLGH 720
           DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESMQELLQNFYTTQKLKETLGH
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESMQELLQNFYTTQKLKETLGH 720


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score = 1437 bits (3719), Expect = 0.0
 Identities = 699/701 (99%), Positives = 700/701 (99%)

Query: 1   MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60
           MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN
Sbjct: 1   MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRN 60

Query: 61  GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120
           GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC
Sbjct: 61  GLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEAC 120

Query: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180
           EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ
Sbjct: 121 EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQ 180

Query: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
           LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240

Query: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
           YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300

Query: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360
           NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR
Sbjct: 301 NVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNR 360

Query: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420
           QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR
Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420

Query: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480
           TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV
Sbjct: 421 TKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYV 480

Query: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
           VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV
Sbjct: 481 VGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540

Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600
           ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLC 600

Query: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660
           APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR
Sbjct: 601 APMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPR 660

Query: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESM 701
           DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE +
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEV 701



 Score =  151 bits (381), Expect = 2e-36
 Identities = 76/190 (40%), Positives = 109/190 (57%), Gaps = 6/190 (3%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +YAVGG D      T+E++D     W ++ +M+  R   GV  ++NKLY +GGRDG  
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS------YLNTVER 542
            L ++E F+P    W++  PMS  R G+GVAT  G +Y VGGHD  +        + VER
Sbjct: 583 CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER 642

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
           +DP+G  W+ VA +S PR  V V  L +KLY +GG DG + L ++E +D   N+W    P
Sbjct: 643 YDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVP 702

Query: 603 MSKRRGGVGV 612
           ++  R G  V
Sbjct: 703 VNIGRAGACV 712



 Score = 96.3 bits (238), Expect = 9e-20
 Identities = 58/171 (33%), Positives = 83/171 (48%), Gaps = 12/171 (7%)

Query: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
           PE R           +STVG       LYA+GG D      ++E +D  TN W     M+
Sbjct: 545 PEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMS 604

Query: 464 GRRLQFGVAVIDNKLYVVGGRDG------LKTLNTVECFNPVGKIWTVMPPMSTHRHGLG 517
            RR   GVA  +  LYVVGG D        +  + VE ++P G  W+ + P+S  R  + 
Sbjct: 605 KRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVA 664

Query: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
           V  L   +Y VGG+DG +YLNTVE +D +  +W     ++  R+   VV +
Sbjct: 665 VCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 6/102 (5%)

Query: 429 GALYAVGGMDAMKG------TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
           G LY VGG DA         +  +E+YD + +SW  +  ++  R    V  + +KLYVVG
Sbjct: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676

Query: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
           G DG   LNTVE ++     W    P++  R G  V  ++ P
Sbjct: 677 GYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP 718


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  932 bits (2410), Expect = 0.0
 Identities = 475/734 (64%), Positives = 563/734 (76%), Gaps = 40/734 (5%)

Query: 1   MSVSGKKEFDVKQILRLRWRWFSHPFQ--GSTNTGSCLQQEG---YEHRGTPVQGRLKSH 55
           MS SG+K+FDVK ILRLRW+ FSHP    G    G CLQQ+G   +EH G P Q RL   
Sbjct: 1   MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWG-PSQSRLLK- 58

Query: 56  SRDRNGLK-----------KSNSPVH--------HNILAPVPGPAPAHQRAVQNLQQHNL 96
           S++R+G+             S+SP          +  L PV              Q    
Sbjct: 59  SQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPART 118

Query: 97  IVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTAR------LDTQHS-- 147
           + + ++ E+  + VP  + F    EK     E+  + DN   +T          T HS  
Sbjct: 119 LFYVESLEE--EVVPGMD-FPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMT 175

Query: 148 --EDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSD 205
              D++++ SEE +  ++HAEQT RKME+YLK++QLCDV+LI G+ +IPAHRLVLS+VSD
Sbjct: 176 PQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSD 235

Query: 206 YFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLT 265
           YFAAMFT+DV EAKQEE++MEG+DPNAL  LVQ+AYTG L+LKEDTIE+LLAAACLLQL 
Sbjct: 236 YFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLP 295

Query: 266 QVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPA 325
           QV++VC +FL+K LHPSNCLGIR+F DAQGC EL+ VAH YTME+ +EVI+NQEFLLLPA
Sbjct: 296 QVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPA 355

Query: 326 NEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLE 385
            E+ KLL SDD+NVPDEETIFHALM WV +D+Q+R  +L MLL++IRLPLLPPQ+LADLE
Sbjct: 356 EELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE 415

Query: 386 TSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTT 445
             ++F  DLECQKL++EAMKYHLLPERR++MQSPRTKPRKSTVG LYAVGGMD  KG TT
Sbjct: 416 NHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT 475

Query: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
           IEKYDLRTN W+  G MNGRRLQFGVAVID+KL+V+GGRDGLKTLNTVEC+NP  K WTV
Sbjct: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535

Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
           +PPMSTHRHGLGV  LEGP+YAVGGHDGWSYLNTVERWDP+ +QW +VASMS  RSTVGV
Sbjct: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595

Query: 566 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625
            ALN KLY++GGRDGSSCL SMEY+DPHTNKW++CAPM KRRGGVGVAT +GFLY VGGH
Sbjct: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655

Query: 626 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN 685
           DAPASNHCSRL D VERYDPK D+W+ VAPLS+PRDAV VC LGD+LY VGGYDG TYLN
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715

Query: 686 TVESYDAQRNEWKE 699
           T+ESYD Q NEW +
Sbjct: 716 TMESYDPQTNEWTQ 729



 Score =  159 bits (401), Expect = 1e-38
 Identities = 80/190 (42%), Positives = 115/190 (60%), Gaps = 6/190 (3%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +YAVGG D      T+E++D ++  W  + +M+  R   GVA ++ KLY VGGRDG  
Sbjct: 553 GPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS 612

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS------YLNTVER 542
            L+++E ++P    W +  PM   R G+GVAT +G +YAVGGHD  +       L+ VER
Sbjct: 613 CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVER 672

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
           +DP+   W  VA +S PR  VGV  L ++LYA+GG DG + L +ME +DP TN+W+  A 
Sbjct: 673 YDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMAS 732

Query: 603 MSKRRGGVGV 612
           ++  R G  V
Sbjct: 733 LNIGRAGACV 742



 Score =  107 bits (268), Expect = 3e-23
 Identities = 58/146 (39%), Positives = 82/146 (56%), Gaps = 6/146 (4%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG-- 486
           G LY+VGG D     +++E YD  TN W     M  RR   GVA  D  LY VGG D   
Sbjct: 600 GKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPA 659

Query: 487 ----LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVER 542
                + L+ VE ++P    WT++ P+S  R  +GV  L   +YAVGG+DG +YLNT+E 
Sbjct: 660 SNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMES 719

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVAL 568
           +DP+  +W  +AS++  R+   VV +
Sbjct: 720 YDPQTNEWTQMASLNIGRAGACVVVI 745



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 42/135 (31%), Positives = 68/135 (50%), Gaps = 11/135 (8%)

Query: 401 MEAMKYHLLPERRSMMQSPRTKPR-----KSTVGALYAVGGMDAMKGTTT------IEKY 449
           + +M+Y+     +  M +P  K R      +  G LYAVGG DA            +E+Y
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERY 673

Query: 450 DLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 509
           D +T++W  +  ++  R   GV ++ ++LY VGG DG   LNT+E ++P    WT M  +
Sbjct: 674 DPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 733

Query: 510 STHRHGLGVATLEGP 524
           +  R G  V  ++ P
Sbjct: 734 NIGRAGACVVVIKQP 748


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  903 bits (2334), Expect = 0.0
 Identities = 451/710 (63%), Positives = 540/710 (76%), Gaps = 39/710 (5%)

Query: 6   KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
           +KEFDVKQIL++RWRWF H    S N+    QQ  + +RG              NG +K 
Sbjct: 5   RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 53

Query: 66  NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
             P    +    P  +  ++R+ Q        + FQ +   P +    VP      E C 
Sbjct: 54  LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 101

Query: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
                ++   D     ++N  DS++   +  S+ +++        S+E F  +NHAEQT 
Sbjct: 102 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 161

Query: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
           +KMENYL+ KQLCDV+L+AG  RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 162 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 221

Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
           PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C  FL+KQLHPSNCLGIRS
Sbjct: 222 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 281

Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
           F DAQGCT+L  VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 282 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 341

Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
           + WV HD++ R+ +L  LL+YIRLPLL PQ LAD+E + +F  D+ECQKL+MEAMKYHLL
Sbjct: 342 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 401

Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
           PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W  +  MNGRRLQF
Sbjct: 402 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 461

Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
           GVAV+D+KLYVVGGRDGLKTLNTVEC+NP  K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 462 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 521

Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
           GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV  L+ KLYA+GGRDGSSCLKS+E 
Sbjct: 522 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 581

Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
           FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN  SRLSDCVERYDPK D 
Sbjct: 582 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 641

Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           W+ VA +S+ RDAV VC LGDKLY VGGYDG  YLNTVE+YD Q NEW +
Sbjct: 642 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 691



 Score =  168 bits (425), Expect = 2e-41
 Identities = 87/192 (45%), Positives = 113/192 (58%), Gaps = 6/192 (3%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +YAVGG D      T+E++D +   W  + TM+  R   GVAV+  KLY VGGRDG  
Sbjct: 515 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 574

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT------VER 542
            L +VECF+P    WT+   MS  R G+GV T  G +YA+GGHD  +   T      VER
Sbjct: 575 CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVER 634

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
           +DP+   W  VASMS  R  VGV  L +KLYA+GG DG + L ++E +DP TN+W+  AP
Sbjct: 635 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 694

Query: 603 MSKRRGGVGVAT 614
           +   R G  V T
Sbjct: 695 LCLGRAGACVVT 706



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 6/100 (6%)

Query: 429 GALYAVGGMDAMKGTTT------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
           G LYA+GG DA     T      +E+YD +T+ W  + +M+  R   GV ++ +KLY VG
Sbjct: 609 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 668

Query: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
           G DG   LNTVE ++P    WT + P+   R G  V T++
Sbjct: 669 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 708


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  903 bits (2334), Expect = 0.0
 Identities = 451/710 (63%), Positives = 540/710 (76%), Gaps = 39/710 (5%)

Query: 6   KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKS 65
           +KEFDVKQIL++RWRWF H    S N+    QQ  + +RG              NG +K 
Sbjct: 51  RKEFDVKQILKIRWRWFGHQ-ASSPNSTVDSQQGEFWNRG----------QTGANGGRKF 99

Query: 66  NSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKS----VPEKNLFKEAC- 120
             P    +    P  +  ++R+ Q        + FQ +   P +    VP      E C 
Sbjct: 100 LDPCSLQL----PLASIGYRRSSQ--------LDFQNSPSWPMASTSEVPAFEFTAEDCG 147

Query: 121 -----EKRAQDLEMMADDNIEDSTARLDTQHSEDMNATR------SEEQFHVINHAEQTL 169
                ++   D     ++N  DS++   +  S+ +++        S+E F  +NHAEQT 
Sbjct: 148 GAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTF 207

Query: 170 RKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
           +KMENYL+ KQLCDV+L+AG  RIPAHRLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+
Sbjct: 208 KKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVE 267

Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
           PN+L SL+QYAYTG L+LKED IE LL+ ACLLQL+QV++ C  FL+KQLHPSNCLGIRS
Sbjct: 268 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRS 327

Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
           F DAQGCT+L  VAH YTMEHF+EVI+NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL
Sbjct: 328 FADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNAL 387

Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
           + WV HD++ R+ +L  LL+YIRLPLL PQ LAD+E + +F  D+ECQKL+MEAMKYHLL
Sbjct: 388 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLL 447

Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
           PERR M+QSPRTKPRKSTVG L+AVGGMD+ KG T+IEKYDLRTN W  +  MNGRRLQF
Sbjct: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507

Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
           GVAV+D+KLYVVGGRDGLKTLNTVEC+NP  K W+VMPPMSTHRHGLGVA LEGPMYAVG
Sbjct: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567

Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
           GHDGWSYLNTVERWDP+ RQWN+VA+MSTPRSTVGV  L+ KLYA+GGRDGSSCLKS+E 
Sbjct: 568 GHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVEC 627

Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
           FDPHTNKW+LCA MSKRRGGVGV T+NG LY +GGHDAPASN  SRLSDCVERYDPK D 
Sbjct: 628 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 687

Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           W+ VA +S+ RDAV VC LGDKLY VGGYDG  YLNTVE+YD Q NEW +
Sbjct: 688 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 737



 Score =  168 bits (425), Expect = 2e-41
 Identities = 87/192 (45%), Positives = 113/192 (58%), Gaps = 6/192 (3%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +YAVGG D      T+E++D +   W  + TM+  R   GVAV+  KLY VGGRDG  
Sbjct: 561 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 620

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT------VER 542
            L +VECF+P    WT+   MS  R G+GV T  G +YA+GGHD  +   T      VER
Sbjct: 621 CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVER 680

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
           +DP+   W  VASMS  R  VGV  L +KLYA+GG DG + L ++E +DP TN+W+  AP
Sbjct: 681 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 740

Query: 603 MSKRRGGVGVAT 614
           +   R G  V T
Sbjct: 741 LCLGRAGACVVT 752



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 6/100 (6%)

Query: 429 GALYAVGGMDAMKGTTT------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
           G LYA+GG DA     T      +E+YD +T+ W  + +M+  R   GV ++ +KLY VG
Sbjct: 655 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714

Query: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
           G DG   LNTVE ++P    WT + P+   R G  V T++
Sbjct: 715 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 754


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  815 bits (2105), Expect = 0.0
 Identities = 382/503 (75%), Positives = 439/503 (87%)

Query: 197 RLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLL 256
           RLVLS+VSDYFAAMFTNDV EA+QEE++MEGV+PN+L SL+QYAYTG L+LKED IE LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233

Query: 257 AAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK 316
           + ACLLQL+QV++ C  FL+KQLHPSNCLGIRSF DAQGCT+L  VAH YTMEHF+EVI+
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293

Query: 317 NQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL 376
           NQEF+LLPA+EI+KLL SDD+N+P+EETI +AL+ WV HD++ R+ +L  LL+YIRLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353

Query: 377 PPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG 436
            PQ LAD+E + +F  D+ECQKL+MEAMKYHLLPERR M+QSPRTKPRKSTVG L+AVGG
Sbjct: 354 APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG 413

Query: 437 MDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
           MD+ KG T+IEKYDLRTN W  +  MNGRRLQFGVAV+D+KLYVVGGRDGLKTLNTVEC+
Sbjct: 414 MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECY 473

Query: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
           NP  K W+VMPPMSTHRHGLGVA LEGPMYAVGGHDGWSYLNTVERWDP+ RQWN+VA+M
Sbjct: 474 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 533

Query: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
           STPRSTVGV  L+ KLYA+GGRDGSSCLKS+E FDPHTNKW+LCA MSKRRGGVGV T+N
Sbjct: 534 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 593

Query: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
           G LY +GGHDAPASN  SRLSDCVERYDPK D W+ VA +S+ RDAV VC LGDKLY VG
Sbjct: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653

Query: 677 GYDGHTYLNTVESYDAQRNEWKE 699
           GYDG  YLNTVE+YD Q NEW +
Sbjct: 654 GYDGQAYLNTVEAYDPQTNEWTQ 676



 Score =  168 bits (425), Expect = 2e-41
 Identities = 87/192 (45%), Positives = 113/192 (58%), Gaps = 6/192 (3%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +YAVGG D      T+E++D +   W  + TM+  R   GVAV+  KLY VGGRDG  
Sbjct: 500 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 559

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT------VER 542
            L +VECF+P    WT+   MS  R G+GV T  G +YA+GGHD  +   T      VER
Sbjct: 560 CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVER 619

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAP 602
           +DP+   W  VASMS  R  VGV  L +KLYA+GG DG + L ++E +DP TN+W+  AP
Sbjct: 620 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 679

Query: 603 MSKRRGGVGVAT 614
           +   R G  V T
Sbjct: 680 LCLGRAGACVVT 691



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 39/100 (39%), Positives = 56/100 (56%), Gaps = 6/100 (6%)

Query: 429 GALYAVGGMDAMKGTTT------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVG 482
           G LYA+GG DA     T      +E+YD +T+ W  + +M+  R   GV ++ +KLY VG
Sbjct: 594 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 653

Query: 483 GRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
           G DG   LNTVE ++P    WT + P+   R G  V T++
Sbjct: 654 GYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVK 693



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 21/48 (43%), Positives = 26/48 (54%)

Query: 6  KKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLK 53
          +KEFDVKQIL++RWRWF H      +T    Q E +    T   G  K
Sbjct: 51 RKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRK 98


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  459 bits (1182), Expect = e-129
 Identities = 235/539 (43%), Positives = 342/539 (63%), Gaps = 10/539 (1%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           H  QTL  +    K ++LCDV+L+ G  +I AHR++LSA S YF AMFT ++ E++Q EV
Sbjct: 50  HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
            +  +D  A+  L+ +AYT  + ++E  +++LL AACLLQL ++ + C  FL +QL PSN
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           CLGIR+F D   C ELL +A K+T  +F EV++++EF+LLPAN++  ++ SD++NV  EE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
            +F+A+M WV + +Q R+ +L  +L ++RLPLL P+ L+  + +  +   D EC+ L+ E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289

Query: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
           A  Y LLP+ R +MQ PRT+PRK       L+AVGG  +    +++E+YD +TN W  + 
Sbjct: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349

Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVA 519
           +M+ RR   GV+V+D+ LY VGG DG   LN+VE ++P    W+  + P ST R  +GVA
Sbjct: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409

Query: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
            L G +YAVGG DG S LN VER+DP+  +W  VASMST R  V V  L   LYA+GG D
Sbjct: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469

Query: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
           G+S L ++E ++P  N+W   APM  RR  +G A Y   +Y VGG D       + LS  
Sbjct: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-----DTTELSS- 523

Query: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
            ERY+P+ + WS V  ++  R  V +  +  +L  VGG+DG TYL T+E +D   N W+
Sbjct: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582



 Score =  165 bits (418), Expect = 1e-40
 Identities = 84/186 (45%), Positives = 114/186 (61%), Gaps = 2/186 (1%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G LYAVGG D +     +E+YD + N W  + +M+ RRL   VAV+   LY VGG DG  
Sbjct: 413 GFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS 472

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
            LNTVE +NP    W  + PM T R  LG A  +  +YAVGG D  + L++ ER++P   
Sbjct: 473 PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTN 532

Query: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRR- 607
           QW+ V +M++ RS VG+  +N +L A+GG DG++ LK++E FDP  N W L   M+ RR 
Sbjct: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592

Query: 608 -GGVGV 612
            GGVGV
Sbjct: 593 GGGVGV 598



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 35/92 (38%), Positives = 51/92 (55%)

Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
           +YAVGG D     ++ E+Y+ RTN W  +  M  RR   G+AV++ +L  VGG DG   L
Sbjct: 509 IYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYL 568

Query: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
            T+E F+P    W +   M+  R G GV  ++
Sbjct: 569 KTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK 600



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 31/62 (50%), Positives = 40/62 (64%)

Query: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           VERYDP+ + W  VA +S  R  V V  L D LY VGG+DG +YLN+VE YD + N+W  
Sbjct: 335 VERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSS 394

Query: 700 SM 701
            +
Sbjct: 395 DV 396



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 23/46 (50%), Positives = 25/46 (54%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
           G L AVGG D      TIE +D   N+W   G MN RRL  GV VI
Sbjct: 554 GQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  444 bits (1141), Expect = e-124
 Identities = 229/537 (42%), Positives = 324/537 (60%), Gaps = 9/537 (1%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           H       M    +   LCD++L      I AH++VL++ S YF AMFTN++ E++Q  V
Sbjct: 74  HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
            +  +DP AL+ LVQ+AYT  + + E  +++LL AA LLQL  V D C  FL+ QL PSN
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           CLGIR F DA  C++LL  AH+Y ++HF++V K +EF+LLP  ++ +L+ SD +NVP EE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
            ++ A++ WV HDV  R+  +  L+  +RLPLL    LL  ++  S+     +C+ LL+E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313

Query: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
           A+K+HLLPE+R ++ + RT+PR+       L+AVGG          E YD RT+ W  + 
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373

Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
           +M+ RR + GVA + N+LY VGG DG   L TVE ++PV   W     M T R  LGVA 
Sbjct: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433

Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
           L G +Y+ GG+DG S LN+ ER+DP    W  VA+MST R  V V  L+  LYA+GG D 
Sbjct: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493

Query: 581 SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
           SS L ++E ++P  N WS  A M  RR   GVA   G LYV GG+D       +   + V
Sbjct: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG------TSCLNSV 547

Query: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
           ERY PK  +W +VAP+++ R    +  +   LY VGG DG + LN++E Y+ + N+W
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604



 Score =  160 bits (406), Expect = 3e-39
 Identities = 82/185 (44%), Positives = 108/185 (58%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G LY+ GG D      + E+YD  T +W  +  M+ RR    VA +D  LY VGG D   
Sbjct: 436 GLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSS 495

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
            L TVE + P   +W+ +  M + R   GVA LEG +Y  GG+DG S LN+VER+ P+  
Sbjct: 496 HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAG 555

Query: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
            W  VA M+  RST  +VA++  LYA+GG DGSS L S+E ++P TNKW   + M  RR 
Sbjct: 556 AWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRS 615

Query: 609 GVGVA 613
            VGVA
Sbjct: 616 SVGVA 620



 Score =  121 bits (304), Expect = 2e-27
 Identities = 63/154 (40%), Positives = 92/154 (59%), Gaps = 1/154 (0%)

Query: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
           M + R   R +T+ G LYAVGG D+     T+EKY+ + N W  + +M  RR   GVAV+
Sbjct: 469 MSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVL 528

Query: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
           +  LYV GG DG   LN+VE ++P    W  + PM+  R    +  ++G +YAVGG+DG 
Sbjct: 529 EGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGS 588

Query: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
           S LN++E+++P   +W   + M T RS+VGV  L
Sbjct: 589 SSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 622



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 36/94 (38%), Positives = 49/94 (52%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           GALY  GG D      ++E+Y  +  +W  +  MN RR    +  +D  LY VGG DG  
Sbjct: 530 GALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSS 589

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
           +LN++E +NP    W     M T R  +GVA LE
Sbjct: 590 SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 36/80 (45%), Positives = 45/80 (56%), Gaps = 6/80 (7%)

Query: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
           L+ VGG    A +      DC E YD + D W  VA +S  R  V V  +G++LY VGGY
Sbjct: 344 LFAVGGGSLFAIH-----GDC-EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGY 397

Query: 679 DGHTYLNTVESYDAQRNEWK 698
           DG + L TVESYD   N W+
Sbjct: 398 DGTSDLATVESYDPVTNTWQ 417


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  405 bits (1041), Expect = e-113
 Identities = 222/552 (40%), Positives = 327/552 (59%), Gaps = 27/552 (4%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           H+EQ L+ +    +  +LCD++L  G ++I AH++VL++VS YF AMFT ++ E +  EV
Sbjct: 17  HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
             + +D  AL ++V+YAYTG + + +DT+ESLL AA LLQ+  V+  C  FL  QL P N
Sbjct: 77  EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           C+GI  F +  GC +L   A KY  ++F  V + +EF  L   ++ +++ +D +NV  EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADL-ETSSMFTGDLECQKLLME 402
           T+F+AL  W+ +DVQ RQ  L  LL+ +RLPLL  + L  L E + +   D  C+ LL E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256

Query: 403 AMKYHLLPERR-----SMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSW 456
           A+KYH +PE R      +M  PR  P+      L AVGG   +     ++E Y  + +SW
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311

Query: 457 LHIGTMNGRRLQFGVAVIDNKLYVVGG-----RDGL---KTLNTVECFNPVGKIWTVMPP 508
           + +  +N  R +FG+ V+D K+YV+GG     R G+   K  N+VEC+NP    WT +  
Sbjct: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371

Query: 509 MSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
           M+  R  LGV  L G +YA+GG+DG SYL +VE++ P+ R+W  VA M+T RS      L
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431

Query: 569 NNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAP 628
           +  +YAIGG  G + + S+E +DP  + W + A M+ +R   GV    GF++VVGGH   
Sbjct: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487

Query: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE 688
             N  S LS  +ERYDP  + W+   P+  PR  V    + + LYVVGG+ G +YLNTV+
Sbjct: 488 --NGVSHLSS-IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544

Query: 689 SYDAQRNEWKES 700
            YD   + W +S
Sbjct: 545 KYDPISDTWLDS 556



 Score =  128 bits (321), Expect = 2e-29
 Identities = 69/209 (33%), Positives = 108/209 (51%), Gaps = 7/209 (3%)

Query: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
           P+  +     R    +ST+G       LYA+GG D      ++EKY  +   W  +  M 
Sbjct: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420

Query: 464 GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
             R  F  AV+D  +Y +GG  G   +N+VE ++P    W ++  M+  R   GV  + G
Sbjct: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479

Query: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
            ++ VGGH+G S+L+++ER+DP   QW     M  PR+ VG   ++N LY +GG  GSS 
Sbjct: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539

Query: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
           L +++ +DP ++ W   A M   R   G+
Sbjct: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568



 Score =  108 bits (270), Expect = 2e-23
 Identities = 64/183 (34%), Positives = 96/183 (52%), Gaps = 9/183 (4%)

Query: 392 GDLECQKLLMEAMKYHLLPERRSMMQ-SPRTKPRKSTV-----GALYAVGGMDAMKGTTT 445
           G  + Q  L    KY  +P+ R     +P T  R         G +YA+GG        +
Sbjct: 392 GGYDGQSYLQSVEKY--IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNS 448

Query: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
           +E+YD   +SW  + +M  +R+ FGV V+   ++VVGG +G+  L+++E ++P    WTV
Sbjct: 449 VERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTV 508

Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
             PM   R G+G A ++  +Y VGGH G SYLNTV+++DP    W   A M   R   G+
Sbjct: 509 CRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568

Query: 566 VAL 568
            AL
Sbjct: 569 TAL 571


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  401 bits (1030), Expect = e-111
 Identities = 217/534 (40%), Positives = 320/534 (59%), Gaps = 14/534 (2%)

Query: 171 KMENYLKEKQL-CDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVD 229
           K+ N L+ KQL CDV+++A  + I AHR+VL+A S YF AMFT D+ E+K +++ ++ VD
Sbjct: 38  KVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVD 97

Query: 230 PNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS 289
              L+ L+ Y YT  +++ E+ ++ LL AA LLQL  V   C +FL  QLHP+NCLGIR+
Sbjct: 98  GQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRA 157

Query: 290 FGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHAL 349
           F D   CT+LL  A+ Y  +HF EV+  +EFL L  +++  L+ SD + V  EE +F A+
Sbjct: 158 FADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAV 217

Query: 350 MQWVGHDVQNRQGELGMLLSYIRLPLLP-PQLLADLETSSMFTGDLECQKLLMEAMKYHL 408
           + W+ ++ + R   +  L+ ++RLPLLP   L+  +E  ++   +  C+  L+EAMKYHL
Sbjct: 218 ISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHL 277

Query: 409 LP-ERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGR 465
           LP ++R ++++PRTKPR   S    +  VGG  A K   ++E YD   + W  I  +  R
Sbjct: 278 LPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSR 336

Query: 466 RLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
           R + GV  +   +Y VGG +G   + TV+ ++ V   WT +  M   R  LG A L   +
Sbjct: 337 RCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLL 396

Query: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--C 583
           YAVGG DG + L +VE +  +  +W +VA M+T RS+VGV  +  KLYA+GG DG+S  C
Sbjct: 397 YAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQC 456

Query: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
           L ++E ++P TN+W   A MS RR G GV   +G LY  GGHD P       +   VE Y
Sbjct: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL------VRKSVEVY 510

Query: 644 DPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
           DP  ++W  VA +++ R    VC +   LYVVGG DG   L +VE Y+   ++W
Sbjct: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564



 Score =  167 bits (422), Expect = 4e-41
 Identities = 91/199 (45%), Positives = 114/199 (57%), Gaps = 9/199 (4%)

Query: 424 RKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNK 477
           R+ST+GA      LYAVGG D   G  ++E Y  +TN W  +  MN RR   GV V++ K
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442

Query: 478 LYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS 535
           LY VGG DG   + L+TVE +NP    W  +  MST R G GV  L G +YA GGHDG  
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502

Query: 536 YLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTN 595
              +VE +DP    W  VA M+  R   GV A+N  LY +GG DGS  L S+EY++P T+
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562

Query: 596 KWSLC-APMSKRRGGVGVA 613
           KW+L    MS  R   GVA
Sbjct: 563 KWTLLPTNMSTGRSYAGVA 581


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  399 bits (1025), Expect = e-111
 Identities = 215/539 (39%), Positives = 315/539 (58%), Gaps = 11/539 (2%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           H ++  + M     +  LCDV ++A  + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 42  HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
           R++ VD   L  L+ Y YT  +Q+ E+ ++ LL AA LLQL  V   C  FL  QLHP N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           CLGIR+F D   CT+LLN A+ Y  +HF +V+ ++EFL L   ++  L+ SD + +  EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
            +F A++ WV HD   RQ  +  L+ ++RLPLLP + L   +E  ++      C+  L+E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281

Query: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
           AMKYHLLP E+R +M+S RT+ R    +  L  V G  A K   ++E YD +   W  + 
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 341

Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
            +  RR + G+  +   ++ VGG +G   + TV+ ++PV   WT +  M   R  LG A 
Sbjct: 342 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 401

Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
           L G +YAVGG DG + L++VE ++ +  +W +VA M+T RS+VGV  +   LYA+GG DG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 461

Query: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
           +S  CL ++E ++  TN+W+  A MS RR G GV   N  LY VGGHD P       +  
Sbjct: 462 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 515

Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
            VE YDP  ++W  VA +++ R    VC +   LYVVGG DG   L +VE Y+   ++W
Sbjct: 516 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 574



 Score =  168 bits (426), Expect = 1e-41
 Identities = 89/200 (44%), Positives = 118/200 (59%), Gaps = 9/200 (4%)

Query: 422 KPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
           + R+ST+GA      LYAVGG D   G +++E Y++++N W H+  MN RR   GV V+ 
Sbjct: 391 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 450

Query: 476 NKLYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDG 533
             LY VGG DG   + L+TVEC+N     WT +  MST R G GV  L   +YAVGGHDG
Sbjct: 451 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 510

Query: 534 WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH 593
                +VE +DP    W  VA M+  R   GV A+N  LY +GG DGS  L S+EY++P 
Sbjct: 511 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 570

Query: 594 TNKWSLCAP-MSKRRGGVGV 612
           T+KW++ +  MS  R   GV
Sbjct: 571 TDKWTVVSSCMSTGRSYAGV 590


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  399 bits (1025), Expect = e-111
 Identities = 215/539 (39%), Positives = 315/539 (58%), Gaps = 11/539 (2%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           H ++  + M     +  LCDV ++A  + I AHR+VL+A S YF AMFT ++ E++ + V
Sbjct: 38  HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
           R++ VD   L  L+ Y YT  +Q+ E+ ++ LL AA LLQL  V   C  FL  QLHP N
Sbjct: 98  RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           CLGIR+F D   CT+LLN A+ Y  +HF +V+ ++EFL L   ++  L+ SD + +  EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
            +F A++ WV HD   RQ  +  L+ ++RLPLLP + L   +E  ++      C+  L+E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277

Query: 403 AMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
           AMKYHLLP E+R +M+S RT+ R    +  L  V G  A K   ++E YD +   W  + 
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA 337

Query: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
            +  RR + G+  +   ++ VGG +G   + TV+ ++PV   WT +  M   R  LG A 
Sbjct: 338 ELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAV 397

Query: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
           L G +YAVGG DG + L++VE ++ +  +W +VA M+T RS+VGV  +   LYA+GG DG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG 457

Query: 581 SS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
           +S  CL ++E ++  TN+W+  A MS RR G GV   N  LY VGGHD P       +  
Sbjct: 458 ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL------VRK 511

Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
            VE YDP  ++W  VA +++ R    VC +   LYVVGG DG   L +VE Y+   ++W
Sbjct: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570



 Score =  168 bits (426), Expect = 1e-41
 Identities = 89/200 (44%), Positives = 118/200 (59%), Gaps = 9/200 (4%)

Query: 422 KPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
           + R+ST+GA      LYAVGG D   G +++E Y++++N W H+  MN RR   GV V+ 
Sbjct: 387 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 446

Query: 476 NKLYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDG 533
             LY VGG DG   + L+TVEC+N     WT +  MST R G GV  L   +YAVGGHDG
Sbjct: 447 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 506

Query: 534 WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH 593
                +VE +DP    W  VA M+  R   GV A+N  LY +GG DGS  L S+EY++P 
Sbjct: 507 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 566

Query: 594 TNKWSLCAP-MSKRRGGVGV 612
           T+KW++ +  MS  R   GV
Sbjct: 567 TDKWTVVSSCMSTGRSYAGV 586


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  395 bits (1016), Expect = e-110
 Identities = 205/540 (37%), Positives = 305/540 (56%), Gaps = 11/540 (2%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
           HA+  L  M +  K   LCDV L       PAHR+VL+A SDYF AMFT+++ E  +  V
Sbjct: 15  HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74

Query: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
            ++G+  + +  L+ + YT  + +  + ++ LL AACLLQL  V   C  FL  QL PSN
Sbjct: 75  DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134

Query: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
           CLGIR F +   C +L+  A  ++ +HF EV++++EF+LL   E+ KL+  D+I V  EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194

Query: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
            +F A++ WV H  + R+  L  LL Y+R+PLL P+ + D ++        L+C+ L+ E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254

Query: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSWLHIGT 461
           A K+HL PE RS MQ PRT+ R      L  VGG  + +     +EKYD +T  W  + +
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314

Query: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGK---IWTVMPPMSTHRHGLGV 518
           +  +R       + +++YV+GG DG   L++VEC +       +W  + PM+  R   G 
Sbjct: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374

Query: 519 ATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 578
            TL   +Y  GG DG     ++ER+DP   QW+ +  M T R   G+V  +  +Y +GG 
Sbjct: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434

Query: 579 DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
           DG + L S+E +DPHT  W+   PM+ +R G GVA  N  +YVVGG D  A  H S    
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA--HLS---- 488

Query: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
            VE Y+ + DSW+TV  ++ PR  V    L  +LY + GYDG++ L+++E YD   + W+
Sbjct: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548



 Score =  144 bits (362), Expect = 4e-34
 Identities = 73/182 (40%), Positives = 103/182 (56%)

Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
           +Y  GG D  +  T++E+YD   + W  +G M   R   G+ V    +Y +GG DGL  L
Sbjct: 381 IYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNIL 440

Query: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQW 550
           N+VE ++P    WT + PM+T R G GVA L   +Y VGG DG ++L++VE ++     W
Sbjct: 441 NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSW 500

Query: 551 NYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGV 610
             V SM+TPR  VG   L  +LYAI G DG+S L S+E +DP  + W +   M  +R   
Sbjct: 501 TTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDA 560

Query: 611 GV 612
           GV
Sbjct: 561 GV 562



 Score =  110 bits (274), Expect = 6e-24
 Identities = 55/143 (38%), Positives = 81/143 (56%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
           G +Y +GG D +    ++EKYD  T  W ++  M  +R   GVA++++ +YVVGG DG  
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485

Query: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
            L++VE +N     WT +  M+T R  +G   L G +YA+ G+DG S L+++E +DP   
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545

Query: 549 QWNYVASMSTPRSTVGVVALNNK 571
            W  V SM T R   GV  L  K
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLREK 568


>gi|34101268 kelch-like 8 [Homo sapiens]
          Length = 620

 Score =  395 bits (1015), Expect = e-110
 Identities = 209/531 (39%), Positives = 313/531 (58%), Gaps = 15/531 (2%)

Query: 175 YLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
           + +  +LCDV L  G   I  H+LVL+ V  YF AMF +++ EAKQ  + +   D +A+ 
Sbjct: 60  FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119

Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
            LV++ Y+  L L  D ++ LL AAC+LQ+  V   C  ++    HPSNCL +R+F ++ 
Sbjct: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179

Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
              +L+++A +Y  +HF EV++ ++F+ +    + KLL S D+N+ +E+ +++A ++W+ 
Sbjct: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239

Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTG-DLECQKLLMEAMKYHLLPERR 413
            + Q+    L   L+ +RLPLLP   L  +         +L+C+ LL EA  YHL    R
Sbjct: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299

Query: 414 SMMQ---SPRTKPRKSTVGALYAVGGMDAMKGT-TTIEKYDLRTNSWLHIGTMNGRRLQF 469
           ++     S RT PRK T G L+ VGG         +IE Y +  NSW     MN RR   
Sbjct: 300 AVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHV 359

Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
           GV  ++ K+Y VGG DG + L ++E F+P+   W +   M+T R G+ +A+L GP+YA+G
Sbjct: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419

Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
           G D  +  N VER+D E  QW+ VA M+TPR  VG VAL N +YA+GG DG + L S+E 
Sbjct: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479

Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD--APASNHCSRLSDCVERYDPKG 647
           +DPH +KW     M +RR G GV+  +G LYVVGG D  +P S+        VERYDP+ 
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRS 531

Query: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
           + W  VA L+ PR  V +  +  K++ VGG++G+ YLNTVE++D   N W+
Sbjct: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWE 582



 Score =  155 bits (393), Expect = 9e-38
 Identities = 80/209 (38%), Positives = 121/209 (57%), Gaps = 4/209 (1%)

Query: 409 LPERRSMMQSPRTKPR----KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNG 464
           L  +  M  S  TK R     S  G +YA+GG+D       +E+YD+ ++ W  +  MN 
Sbjct: 389 LTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNT 448

Query: 465 RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
            R   G   + N +Y VGG DG+ +L++VE ++P    W  +  M   R G GV+ L G 
Sbjct: 449 PRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGC 508

Query: 525 MYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCL 584
           +Y VGG D  S L++VER+DP   +W+YVA+++TPR  VG+  +  K++A+GG +G++ L
Sbjct: 509 LYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL 568

Query: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVA 613
            ++E FDP  N+W L   +S  R G GVA
Sbjct: 569 NTVEAFDPVLNRWELVGSVSHCRAGAGVA 597



 Score =  133 bits (334), Expect = 7e-31
 Identities = 71/178 (39%), Positives = 103/178 (57%), Gaps = 7/178 (3%)

Query: 523 GPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS 581
           G ++ VGG  G      ++E +      W +   M++ R  VGV+++  K+YA+GG DG+
Sbjct: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377

Query: 582 SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641
             L SME FDP TNKW + A M+ +R G+ +A+  G +Y +GG D    N C    + VE
Sbjct: 378 EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD---DNTCF---NDVE 431

Query: 642 RYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           RYD + D WSTVAP++ PR  V    L + +Y VGG DG   L++VE YD   ++W E
Sbjct: 432 RYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE 489



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 16/48 (33%), Positives = 27/48 (56%)

Query: 426 STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
           + +G ++AVGG +      T+E +D   N W  +G+++  R   GVAV
Sbjct: 551 TVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  395 bits (1014), Expect = e-110
 Identities = 207/530 (39%), Positives = 304/530 (57%), Gaps = 10/530 (1%)

Query: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
           ME   ++ +LCDV L  G  +  AHR+VL+A   YF AMFTND++E KQ+E+ M+G+DP+
Sbjct: 28  MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87

Query: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
           AL +L+ +AY G L + +  ++SLL  A  LQL  + D C  FL ++LHP NCLG+R F 
Sbjct: 88  ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147

Query: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
           +   C  L + A+ +  +HF+EV  ++EFL LP  ++ +L+  D++NV  EE +F A + 
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207

Query: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
           WV +D + R   L  LLS IRLPL  PQ L+D ++   +     +C+ L+ EA  YHL+P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267

Query: 411 ERRSMMQSPRTKPR--KSTVGALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
           ERR  + + RT+PR   S  G +YAVGG++ A      +E +D   N W     M   R 
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327

Query: 468 QFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA 527
           + GVAV++  LY +GG DG   L+TVE +NP    WT +  M++ R  +G   L+G +Y 
Sbjct: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387

Query: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSM 587
            GG+DG S L++VE + PE  +W  V SMS+ RS  GV     ++Y  GG DG     S+
Sbjct: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447

Query: 588 EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKG 647
           E+++ HT  W   A M  +R   G A+    ++V GG+D       S      E Y    
Sbjct: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501

Query: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
           D W  + P+   R  V++     +LY VGGYDG + L++VE YD + + W
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 1/107 (0%)

Query: 416 MQSPRTKPRKSTVGA-LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
           M + R +   +++G+ ++  GG D     +  E Y    + W  I  M+ RR +  +   
Sbjct: 463 MLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVAS 522

Query: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
             +LY VGG DG   L++VE ++P    WT M PM+ H  G+GV  +
Sbjct: 523 CGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCI 569


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score =  357 bits (916), Expect = 2e-98
 Identities = 194/486 (39%), Positives = 283/486 (58%), Gaps = 11/486 (2%)

Query: 217 EAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLI 276
           E++ + VR++ VD   L  L+ Y YT  +Q+ E+ ++ LL AA LLQL  V   C  FL 
Sbjct: 3   ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62

Query: 277 KQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD 336
            QLHP NCLGIR+F D   CT+LLN A+ Y  +HF +V+ ++EFL L   ++  L+ SD 
Sbjct: 63  SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122

Query: 337 INVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLE 395
           + +  EE +F A++ WV HD   RQ  +  L+ ++RLPLLP + L   +E  ++      
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182

Query: 396 CQKLLMEAMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRT 453
           C+  L+EAMKYHLLP E+R +M+S RT+ R    +  L  V G  A K   ++E YD + 
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242

Query: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHR 513
             W  +  +  RR + G+  +   ++ VGG +G   + TV+ ++PV   WT +  M   R
Sbjct: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302

Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
             LG A L G +YAVGG DG + L++VE ++ +  +W +VA M+T RS+VGV  +   LY
Sbjct: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362

Query: 574 AIGGRDGSS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASN 631
           A+GG DG+S  CL ++E ++  TN+W+  A MS RR G GV   N  LY VGGHD P   
Sbjct: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420

Query: 632 HCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYD 691
               +   VE YDP  ++W  VA +++ R    VC +   LYVVGG DG   L +VE Y+
Sbjct: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476

Query: 692 AQRNEW 697
              ++W
Sbjct: 477 PTTDKW 482



 Score =  168 bits (426), Expect = 1e-41
 Identities = 89/200 (44%), Positives = 118/200 (59%), Gaps = 9/200 (4%)

Query: 422 KPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
           + R+ST+GA      LYAVGG D   G +++E Y++++N W H+  MN RR   GV V+ 
Sbjct: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358

Query: 476 NKLYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDG 533
             LY VGG DG   + L+TVEC+N     WT +  MST R G GV  L   +YAVGGHDG
Sbjct: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418

Query: 534 WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH 593
                +VE +DP    W  VA M+  R   GV A+N  LY +GG DGS  L S+EY++P 
Sbjct: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478

Query: 594 TNKWSLCAP-MSKRRGGVGV 612
           T+KW++ +  MS  R   GV
Sbjct: 479 TDKWTVVSSCMSTGRSYAGV 498


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  334 bits (857), Expect = 1e-91
 Identities = 197/590 (33%), Positives = 304/590 (51%), Gaps = 29/590 (4%)

Query: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
           C + A D  M A      +  + +   S+  N T S   + + +H +Q    M      +
Sbjct: 23  CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74

Query: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
           QLCDV L   +   PA     H++VL++ S  F AMFTN + E   E V +EG+ P  + 
Sbjct: 75  QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134

Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
            L+++AYT  + + E  +  ++  A + Q+  V+  CS+FL++QL PSN +GI +F +  
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194

Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
           GC EL   A +Y   HF EV K +EF  L   ++  L+  DD+NV  E  +FHA + WV 
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254

Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
           +D + R+  +  LL  +R   L P  L   L+   +   D  C+  L++  +   L +  
Sbjct: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314

Query: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
            +M       R   VG L    G    +  + +E Y+    +WL +  +   R      V
Sbjct: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369

Query: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
           +   LY VGGR    DG    + ++C+NP+   W+   PMS  R+ +GV  ++G +YAVG
Sbjct: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429

Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
           G  G  + N+VER++PE  +W+ VA M T R  VGV  LN  LYA+GG DG++ L S E 
Sbjct: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489

Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
           + P  N+W +   M+  R G GV   +  +Y  GG+D           + VERYD + ++
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543

Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           W+ VAP+   R A+ +     ++YV+GGYDGHT+L++VE YD   + W E
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593



 Score =  153 bits (386), Expect = 6e-37
 Identities = 79/199 (39%), Positives = 111/199 (55%), Gaps = 1/199 (0%)

Query: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
           M  PR +     + G +YAVGG        ++E+Y+   + W  +  M  RR+  GVAV+
Sbjct: 409 MSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL 468

Query: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
           +  LY VGG DG   LN+ EC+ P    W ++  M+T R G GV  L   +YA GG+DG 
Sbjct: 469 NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ 528

Query: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594
             LN+VER+D E   W +VA M   RS +G+     ++Y +GG DG + L S+E +DP T
Sbjct: 529 DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDT 588

Query: 595 NKWSLCAPMSKRRGGVGVA 613
           + WS    M+  R GVGVA
Sbjct: 589 DTWSEVTRMTSGRSGVGVA 607



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 34/94 (36%), Positives = 54/94 (57%)

Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
           +YA GG D      ++E+YD+ T +W  +  M  RR   G+ V   ++YV+GG DG   L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578

Query: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
           ++VEC++P    W+ +  M++ R G+GVA    P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 16/45 (35%), Positives = 23/45 (51%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
           G +Y +GG D      ++E YD  T++W  +  M   R   GVAV
Sbjct: 564 GRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  334 bits (857), Expect = 1e-91
 Identities = 197/590 (33%), Positives = 304/590 (51%), Gaps = 29/590 (4%)

Query: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
           C + A D  M A      +  + +   S+  N T S   + + +H +Q    M      +
Sbjct: 23  CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74

Query: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
           QLCDV L   +   PA     H++VL++ S  F AMFTN + E   E V +EG+ P  + 
Sbjct: 75  QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134

Query: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
            L+++AYT  + + E  +  ++  A + Q+  V+  CS+FL++QL PSN +GI +F +  
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194

Query: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
           GC EL   A +Y   HF EV K +EF  L   ++  L+  DD+NV  E  +FHA + WV 
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254

Query: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
           +D + R+  +  LL  +R   L P  L   L+   +   D  C+  L++  +   L +  
Sbjct: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314

Query: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
            +M       R   VG L    G    +  + +E Y+    +WL +  +   R      V
Sbjct: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369

Query: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
           +   LY VGGR    DG    + ++C+NP+   W+   PMS  R+ +GV  ++G +YAVG
Sbjct: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429

Query: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
           G  G  + N+VER++PE  +W+ VA M T R  VGV  LN  LYA+GG DG++ L S E 
Sbjct: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489

Query: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
           + P  N+W +   M+  R G GV   +  +Y  GG+D           + VERYD + ++
Sbjct: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543

Query: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
           W+ VAP+   R A+ +     ++YV+GGYDGHT+L++VE YD   + W E
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593



 Score =  153 bits (386), Expect = 6e-37
 Identities = 79/199 (39%), Positives = 111/199 (55%), Gaps = 1/199 (0%)

Query: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
           M  PR +     + G +YAVGG        ++E+Y+   + W  +  M  RR+  GVAV+
Sbjct: 409 MSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL 468

Query: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
           +  LY VGG DG   LN+ EC+ P    W ++  M+T R G GV  L   +YA GG+DG 
Sbjct: 469 NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ 528

Query: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594
             LN+VER+D E   W +VA M   RS +G+     ++Y +GG DG + L S+E +DP T
Sbjct: 529 DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDT 588

Query: 595 NKWSLCAPMSKRRGGVGVA 613
           + WS    M+  R GVGVA
Sbjct: 589 DTWSEVTRMTSGRSGVGVA 607



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 34/94 (36%), Positives = 54/94 (57%)

Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
           +YA GG D      ++E+YD+ T +W  +  M  RR   G+ V   ++YV+GG DG   L
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578

Query: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
           ++VEC++P    W+ +  M++ R G+GVA    P
Sbjct: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 16/45 (35%), Positives = 23/45 (51%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
           G +Y +GG D      ++E YD  T++W  +  M   R   GVAV
Sbjct: 564 GRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score =  322 bits (825), Expect = 8e-88
 Identities = 189/564 (33%), Positives = 293/564 (51%), Gaps = 24/564 (4%)

Query: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
           ++  F    HA+  L ++      +  CDV L  G     AHRLVL+A S YFAA+FT  
Sbjct: 10  ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69

Query: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
           + E+ ++ V + G++      L+ + YTG++ +  + ++ L+ AA +LQLT+V+ +C  F
Sbjct: 70  MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129

Query: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
           L  Q+ P NC+GI  F +   C +LL  +  Y   HF+EV   +EFL L  +++ K+L S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189

Query: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
           +++++ DE  +F A MQW+  D+  R+  +  +L  IR PLLPPQ LL  +E  S F   
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249

Query: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
           +  Q LL E  +    P+     S +Q+ + +PRK     LYAVGG   ++G        
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309

Query: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
            + +E++D  +  W  + +++  R   GV V+   +Y +GG       +  EC++PV K 
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369

Query: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
           WT +  M+  R GLGV    G +YA+GG  G    NT+ER+DP+  +W  V +M+  R  
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429

Query: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
            G   +   +Y IGG       L+S E +DP + +WS   PM  RR  +GVA  N  +Y 
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489

Query: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
           VGG      N        VE+Y  + + W  VA + VPR  + V  +   LYV GG    
Sbjct: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544

Query: 681 HTY-----LNTVESYDAQRNEWKE 699
           H +     L++VE Y+   + W E
Sbjct: 545 HDFLAPGTLDSVEVYNPHSDTWTE 568



 Score =  124 bits (312), Expect = 2e-28
 Identities = 75/195 (38%), Positives = 111/195 (56%), Gaps = 12/195 (6%)

Query: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG--RDG 486
           GA+YA+GG    +   TIE++D   N W  +G M   R  FG   +   +YV+GG   +G
Sbjct: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449

Query: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERWDP 545
           ++ L + E ++P+ K W+ +PPM T R  LGVA L   +Y+VGG ++    L+TVE++  
Sbjct: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508

Query: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS------SCLKSMEYFDPHTNKWSL 599
           E  +W  VASM  PR+ + VVA+N  LY  GGR  S        L S+E ++PH++ W+ 
Sbjct: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568

Query: 600 CAPM--SKRRGGVGV 612
              M  S+  GGV V
Sbjct: 569 IGNMITSRCEGGVAV 583



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 45/146 (30%), Positives = 69/146 (47%), Gaps = 14/146 (9%)

Query: 572 LYAIGGR--------DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
           LYA+GG           S  L  +E FD  +  W+  + + + R G+GV    G +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349

Query: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY 683
           G         S + DC E YDP    W+TVA ++ PR  + VC     +Y +GG+ G   
Sbjct: 350 GEKD------SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEI 403

Query: 684 LNTVESYDAQRNEWKESMQELLQNFY 709
            NT+E +D   N+W+      +  +Y
Sbjct: 404 GNTIERFDPDENKWEVVGNMAVSRYY 429



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 7/98 (7%)

Query: 431 LYAVGGMDAMKGTT-TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK- 488
           +Y+VGG +  +    T+EKY      W+ + +M   R    V  ++  LYV GGR     
Sbjct: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546

Query: 489 -----TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
                TL++VE +NP    WT +  M T R   GVA L
Sbjct: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score =  322 bits (824), Expect = 1e-87
 Identities = 180/564 (31%), Positives = 300/564 (53%), Gaps = 20/564 (3%)

Query: 149 DMNATRSEEQFHVINHAEQTLRKME----NYLK-EKQLCDVLLIAGHLRIPAHRLVLSAV 203
           +M +  +  +FH   H E+ +  M     N L+ E +LCDV++        AH+ +L + 
Sbjct: 2   EMESAAASTRFHQ-PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSC 60

Query: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
           S YF A+FT+     +++   + G+ P+ +  +++YAYT  + +  D +E LLAAA    
Sbjct: 61  SSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFN 120

Query: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIK-NQEFLL 322
           +  ++  C  FL  +L   NC+GI  F D   C EL   A+ + + +F E++K + EFL 
Sbjct: 121 IMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE 180

Query: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LL 381
           L   E+  ++  D++NV  E+ +F A+++W+ HD QNR+  + +LL  +RL L+  +  +
Sbjct: 181 LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFM 240

Query: 382 ADLETSSMFTGDLECQKLLMEAMK----YHLLPERRSMMQSPRTKPRKSTVGALYAVGGM 437
            +++ +       EC+ +++ A+K     ++     S   +P T+PR      L+A+GG 
Sbjct: 241 NNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLP-YAILFAIGGW 299

Query: 438 DAMKGTTTIEKYDLRTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECF 496
                T  IE YD R + W+++       R   G A +   +Y++GG D +   N+V+ F
Sbjct: 300 SGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRF 359

Query: 497 NPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASM 556
           +PV K W  + PM + R  + V  L   +YA+GG DG+  LNT ER++PE  QW  +A M
Sbjct: 360 DPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419

Query: 557 STPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYN 616
              RS      L  K+Y  GG +G+ CL + E ++  +N+W++ APM  RR G+GV  Y 
Sbjct: 420 HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYG 479

Query: 617 GFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 676
             +Y VGG D       +RL    E Y P  ++W T+  +  PR    +  + D L+VVG
Sbjct: 480 EHVYAVGGFDG-----ANRLRS-AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVG 533

Query: 677 GYDGHTYLNTVESYDAQRNEWKES 700
           G++G T    VE YD + +EW ++
Sbjct: 534 GFNGFTTTFNVECYDEKTDEWYDA 557


>gi|223890235 intracisternal A particle-promoted polypeptide isoform
           2 [Homo sapiens]
          Length = 582

 Score =  319 bits (818), Expect = 5e-87
 Identities = 192/574 (33%), Positives = 296/574 (51%), Gaps = 21/574 (3%)

Query: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
           ++  F    HA+  L ++      +  CDV L  G     AHRLVL+A S YFAA+FT  
Sbjct: 10  ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69

Query: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
           + E+ ++ V + G++      L+ + YTG++ +  + ++ L+ AA +LQLT+V+ +C  F
Sbjct: 70  MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129

Query: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
           L  Q+ P NC+GI  F +   C +LL  +  Y   HF+EV   +EFL L  +++ K+L S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189

Query: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
           +++++ DE  +F A MQW+  D+  R+  +  +L  IR PLLPPQ LL  +E  S F   
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249

Query: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
           +  Q LL E  +    P+     S +Q+ + +PRK     LYAVGG   ++G        
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309

Query: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
            + +E++D  +  W  + +++  R   GV V+   +Y +GG       +  EC++PV K 
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369

Query: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
           WT +  M+  R GLGV    G +YA+GG  G    NT+ER+DP+  +W  V +M+  R  
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429

Query: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
            G   +   +Y IGG       L+S E +DP + +WS   PM  RR  +GVA  N  +Y 
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489

Query: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
           VGG      N        VE+Y  + + W  VA + VPR  + V  +   LYV GG    
Sbjct: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544

Query: 681 HTYL-NTVESYDAQRNEWKESMQELLQNFYTTQK 713
           H +L      Y+  R +W E+M  L  +  T  K
Sbjct: 545 HDFLAPDTHRYEVFRLKW-ENMCILFNDHKTLTK 577


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score =  266 bits (680), Expect = 5e-71
 Identities = 169/546 (30%), Positives = 268/546 (49%), Gaps = 15/546 (2%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
           H+   L+  +    E  LCDV L+ G      P HR+++++ SDYF AMFT  + E    
Sbjct: 74  HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133

Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
            +++ GV    L  ++ + YT  L L  D ++  L AA  LQ+  V+D C  FLI  +  
Sbjct: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193

Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
            NC+ +    +    TE+    + + +++F  ++   EFL LP   ++ +L S+ +    
Sbjct: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253

Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
           E  +F A  +W+  + + R      L+  IR PL+ PQ L+  ++T      D  C  LL
Sbjct: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312

Query: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
           +EA  Y ++P  + +MQS RT  R  T   L  +GG+    +  +  +  YD + + W  
Sbjct: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371

Query: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
           +  M+  R Q G+AVI N LYVVGG+      G   ++TV  F+P    W  +  ++  R
Sbjct: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431

Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
               ++ L+G +YAVGG +    L TVE ++P   +W YVA MS P            +Y
Sbjct: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491

Query: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
             GG    +  K +  FDP T+KW   APM+  RG   + T    LYV+GG+    ++  
Sbjct: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551

Query: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
             +  C E Y P  D W+ +A +   +  V V    +K+YVVGGY  +    +  V+ YD
Sbjct: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610

Query: 692 AQRNEW 697
             ++EW
Sbjct: 611 PDKDEW 616


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score =  265 bits (678), Expect = 8e-71
 Identities = 163/522 (31%), Positives = 262/522 (50%), Gaps = 24/522 (4%)

Query: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
           +HAE  L+    +   +   DV++       P HR VLSA S YF AMF ND  E+++  
Sbjct: 47  SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106

Query: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
           V + G+   A+   +QY YTG +++  + ++ L   + L Q++ + D C+ FL +QL P 
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166

Query: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
           NCLGI+ F D      L      + ++ F +V +++EFL L  +E+   +CSD++ +  E
Sbjct: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226

Query: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLM 401
           E +F A+M+WV   V  R+  L  LL+++RLPLL P   +  +E   +     EC +LL 
Sbjct: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286

Query: 402 EAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTT--IEKYDLRTNSWL 457
           EA +YH+L      M SPRT+PR+ST     +  VGG + + G      E YD  T  W 
Sbjct: 287 EARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343

Query: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
            +  +    + ++ V  + N + V GGR   +    V  +N    IW  +  ++  R   
Sbjct: 344 SLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGRWRH 400

Query: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI- 575
            +A L G +Y VGG+DG + L++VE +D    +W  VA +    S+  V +   KL+ I 
Sbjct: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460

Query: 576 GGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSR 635
           GG D ++C   ++ +DP TN W L A +   +  +   + N  +YV GG           
Sbjct: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG----------- 509

Query: 636 LSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
           L+  +  YDP  D W  V      ++   +     K+Y++GG
Sbjct: 510 LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG 551



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 64/198 (32%), Positives = 93/198 (46%), Gaps = 18/198 (9%)

Query: 505 VMPPMSTHRHGLG---VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMST-PR 560
           +M P +  R   G   V  + G    VGG +    L   E +DP   +W  +A +    +
Sbjct: 298 MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTK 353

Query: 561 STVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
           S   V AL N +   GGR  S   + +  ++   N W   A ++K R    +A   G +Y
Sbjct: 354 SEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410

Query: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY-D 679
           VVGG+D       +RLS  VE YD   + W+ VAPL     + AV     KL+V+GG  D
Sbjct: 411 VVGGYDGQ-----NRLSS-VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPD 464

Query: 680 GHTYLNTVESYDAQRNEW 697
            +T  + V+SYD + N W
Sbjct: 465 DNTCSDKVQSYDPETNSW 482



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 50/185 (27%), Positives = 78/185 (42%), Gaps = 17/185 (9%)

Query: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
           V T+E         + +  L+   R+   G +   ++  + PR + G    +  +  +GG
Sbjct: 266 VQTVEVDQLIQNSPECYQLLHEARRYHILGNEM--MSPRTRPRRSTGY---SEVIVVVGG 320

Query: 578 --RDGSSCLKSMEYFDPHTNKWSLCAPMSK-RRGGVGVATYNGFLYVVGGHDAPASNHCS 634
             R G   L   E +DP T +W   A + +  +    V      + V GG          
Sbjct: 321 CERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN------- 373

Query: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQR 694
             S  V  Y+ + + W  VA L+  R    +  L  K+YVVGGYDG   L++VE YD+  
Sbjct: 374 --SRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431

Query: 695 NEWKE 699
           N W E
Sbjct: 432 NRWTE 436



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 10/87 (11%)

Query: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGLKT 489
           +Y  GG+     T  I  YD   + W+H+     R+   G++V + K+Y++GG R+  + 
Sbjct: 504 IYVAGGL-----TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558

Query: 490 LNTVECFNPVGKIWT---VMP-PMSTH 512
            +T+ C++P   I T    MP P+S H
Sbjct: 559 TDTILCYDPATSIITGVAAMPRPVSYH 585


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  263 bits (671), Expect = 5e-70
 Identities = 165/533 (30%), Positives = 261/533 (48%), Gaps = 18/533 (3%)

Query: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
           M N  K+K LCDV+L+    +IPAHR+VL+A S +F  MFT ++LE+K  EV ++  +P+
Sbjct: 34  MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93

Query: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
            +  LV++AYT  + +  + ++SLL AA   Q+  V  +C +FL +Q+  SNCLGI    
Sbjct: 94  IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153

Query: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
           +   C EL   A  +  +HF EV K  EFL L    ++ LL  D + V  E+ ++ A ++
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213

Query: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL- 409
           W+ +D  NRQ  +  +L+ +R PL+    L+  ++   +   + EC K+++  M+YHLL 
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273

Query: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
           PE R  +       RK     +   GG        +   ++ +  SW  I     +R   
Sbjct: 274 PEDREELVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDA 329

Query: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
                DN +Y++GG   L  +  ++C+N V   W       T R  L     EG +Y  G
Sbjct: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388

Query: 530 GHD-GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CL 584
           G + G S L   E +D     W+   SM T R + G+V  N  +Y  GG  G++     L
Sbjct: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448

Query: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644
            S E +DP T  W+   PM + R   G+      ++ VGG +           D VE YD
Sbjct: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502

Query: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
            K + W  V+P+      V    +G  +YV+ G+ G   L  +  Y+ + ++W
Sbjct: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score =  261 bits (668), Expect = 1e-69
 Identities = 167/546 (30%), Positives = 265/546 (48%), Gaps = 15/546 (2%)

Query: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR--IPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
           H+   L+  +    E  LCDV L+ G      P HR ++++ SDYF AMFT  + E    
Sbjct: 32  HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91

Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
            +++ GV+   L  ++ + YT  L L  D ++  L AA  LQ+  V+D C  FLI  +  
Sbjct: 92  CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151

Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
            NC+ +    +     E+    + + +++F  ++   EFL LP   ++ +L S+ +    
Sbjct: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211

Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
           E  +F A  +W+  +   R      L+  IR PL+ PQ L+  ++T      D  C  LL
Sbjct: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270

Query: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
           +EA  Y ++P  + +MQS RT  R  +   L  +GG+    +  +  +  YD R   W  
Sbjct: 271 LEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELRMYDERAQEWRS 329

Query: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
           +  M+  R Q G+AVI N LYVVGG+      G   ++TV  F+P    W  +  ++  R
Sbjct: 330 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 389

Query: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
               ++ L+G +YAVGG      L TVE ++P   +W+YVA MS P            +Y
Sbjct: 390 TFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMY 449

Query: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
             GG    +    +  FDP T+KW   APM+  RG   + T    LYV+GG+    ++  
Sbjct: 450 ISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDY 509

Query: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
             +  C E Y P  D W+ +A +   +  V V    +K+YVVGGY  +    +  V+ YD
Sbjct: 510 DDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 568

Query: 692 AQRNEW 697
            +++EW
Sbjct: 569 PEKDEW 574



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 11/162 (6%)

Query: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD-----GSSCLKSMEYFDPHTNKW 597
           +D   ++W  +A M  PR   G+  + N LY +GG+      G + + ++  FDP  NKW
Sbjct: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379

Query: 598 SLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLS 657
              A ++++R    ++   G LY VGG  A            VE Y+P+ + WS VA +S
Sbjct: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGE------LATVECYNPRMNEWSYVAKMS 433

Query: 658 VPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
            P    A    G  +Y+ GG    T+ N +  +D   ++W +
Sbjct: 434 EPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQ 475


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score =  257 bits (657), Expect = 2e-68
 Identities = 162/527 (30%), Positives = 258/527 (48%), Gaps = 18/527 (3%)

Query: 178 EKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLV 237
           +K LCDV+L+    +IPAHR+VL+A S +F  MFT ++LE+K  EV ++  +P+ +  LV
Sbjct: 18  KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77

Query: 238 QYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCT 297
           ++AYT  + +  + ++SLL AA   Q+  V  +C +FL +Q+  SNCLGI    +   C 
Sbjct: 78  EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137

Query: 298 ELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDV 357
           EL   A  +  +HF EV K  EFL L    ++ LL  D + V  E+ ++ A ++W+ +D 
Sbjct: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197

Query: 358 QNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL-PERRSM 415
            NRQ  +  +L+ +R PL+    L+  ++   +   + EC K+++  M+YHLL PE R  
Sbjct: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE 257

Query: 416 MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
           +       RK     +   GG        +   ++ +  SW  I     +R        D
Sbjct: 258 LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313

Query: 476 NKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD-GW 534
           N +Y++GG   L  +  ++C+N V   W       T R  L     EG +Y  GG + G 
Sbjct: 314 NVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372

Query: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CLKSMEYF 590
           S L   E +D     W+   SM T R + G+V  N  +Y  GG  G++     L S E +
Sbjct: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432

Query: 591 DPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSW 650
           DP T  W+   PM + R   G+      ++ VGG +           D VE YD K + W
Sbjct: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYDIKLNEW 486

Query: 651 STVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
             V+P+      V    +G  +YV+ G+ G   L  +  Y+ + ++W
Sbjct: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533


>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
          Length = 642

 Score =  250 bits (638), Expect = 4e-66
 Identities = 170/584 (29%), Positives = 278/584 (47%), Gaps = 57/584 (9%)

Query: 163 NHAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
           N  E ++ K+    K  Q CDV L + GH  + AHR VL+  S Y   +F +D       
Sbjct: 13  NFIESSVAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGIS 71

Query: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
            V+ + ++P A+  L+ YAYT  L+  ++ ++ + +AA  L++ +V  VC ++L+ ++  
Sbjct: 72  HVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131

Query: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
           ++C+  R+F    G + LLN    Y  EH +++ + +EFL LP  ++  +L  D++ +P 
Sbjct: 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPS 190

Query: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIR----------------------------- 372
              ++  ++ WV   +      L  L+  ++                             
Sbjct: 191 NGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDH 250

Query: 373 ---LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVG 429
              +   PP+     + SS  TG L      +++ K H      S   S  T    + + 
Sbjct: 251 IQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPK-HEWKIVASEKTSNNTYLCLAVLD 309

Query: 430 ALYAV----GGMDAMKGTTTIEK------YDLRTNSWLH--IGTMNGRRLQFGVAVIDNK 477
            ++ V    G        T+  K      ++++ +  +   +  M   R   G A ++ K
Sbjct: 310 GIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGK 369

Query: 478 LYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY- 536
           L   GG +  + L TVEC+NP    W+ + PM T R    +A L G +Y VGG +G S  
Sbjct: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429

Query: 537 LNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHT 594
           L+  E +D     W  V  + T R   GV ALN KLY +GG D  G   LK+ + FDP T
Sbjct: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489

Query: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
             W+ CAP++ RR    V    G+LY++GG +   S +C    + VERY+P+ ++W+ +A
Sbjct: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE---SWNCL---NTVERYNPENNTWTLIA 543

Query: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
           P++V R    V  L  KL+V GG+DG   ++ VE YD  RNEWK
Sbjct: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWK 587



 Score =  182 bits (463), Expect = 7e-46
 Identities = 106/305 (34%), Positives = 158/305 (51%), Gaps = 10/305 (3%)

Query: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNS 455
           + L  E  +  L+ +  S MQ  R+    + + G L A GG +  +   T+E Y+  T+ 
Sbjct: 335 KSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH 394

Query: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT-LNTVECFNPVGKIWTVMPPMSTHRH 514
           W  +  M   R +F +AV+  +LYVVGG +G    L+  E ++     W  +P + T+R 
Sbjct: 395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRC 454

Query: 515 GLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572
             GV  L G +Y VGG D  G   L   + +DP  + W   A ++  R    V  L   L
Sbjct: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514

Query: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632
           Y IGG +  +CL ++E ++P  N W+L APM+  R G GVA  NG L+V GG D      
Sbjct: 515 YIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDG----- 569

Query: 633 CSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDA 692
            S    CVE YDP  + W  +  ++ PR    +  +G+ +Y VGG+DG+ +LNTVE Y+ 
Sbjct: 570 -SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNL 628

Query: 693 QRNEW 697
           + NEW
Sbjct: 629 ESNEW 633



 Score =  164 bits (416), Expect = 2e-40
 Identities = 85/240 (35%), Positives = 127/240 (52%), Gaps = 10/240 (4%)

Query: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTI-EKYDLRTNSWLHIGTMNGRRLQFGVAV 473
           M++PR + + + + G LY VGG +      +  E YD   + W+ +  +   R   GV  
Sbjct: 401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460

Query: 474 IDNKLYVVGGRD--GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGH 531
           ++ KLY+VGG D  G K L   + F+PV K+WT   P++  RH   V  L G +Y +GG 
Sbjct: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520

Query: 532 DGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFD 591
           + W+ LNTVER++PE   W  +A M+  R   GV  LN KL+  GG DGS  +  +E +D
Sbjct: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYD 580

Query: 592 PHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWS 651
           P  N+W +   M+  R   G+AT    +Y VGG D       +   + VE Y+ + + WS
Sbjct: 581 PTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDG------NEFLNTVEVYNLESNEWS 634


>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score =  246 bits (628), Expect = 5e-65
 Identities = 165/561 (29%), Positives = 265/561 (47%), Gaps = 26/561 (4%)

Query: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218
           F   +H+   L+ +     + QL DV+L       PAH++VL+A SDYF AMFT  + EA
Sbjct: 40  FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99

Query: 219 KQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278
            Q+ + ++GV    L  ++ +AY+  + L  D ++ +L AA  LQ+  V+++C  FL   
Sbjct: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159

Query: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338
           +    CL I           L      +T  HF+++ + ++FL LP   +   L S+ + 
Sbjct: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219

Query: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQ 397
              E  +F A ++W+ HD   R+     +L +IR PL+    L D ++T  +   D+ C+
Sbjct: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278

Query: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEK--YDLRTNS 455
           + L+EA  Y +LP R+  MQSPRT  R S V +L   GG        ++    Y L    
Sbjct: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVR-SDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337

Query: 456 WLHIGTMNGRRLQFG-----VAVIDNKLYVVGG-----RDGLKTLNTVECFNPVGKIWTV 505
             H   +    ++ G     VAV+DN +YV GG     R G   ++    ++P    W  
Sbjct: 338 ARHFRELT--EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395

Query: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
           +  M   R    +  L G +YA GG +    L +VER+ P   +W Y  S+         
Sbjct: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455

Query: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
            A   +LY  GG   S    K++  +DP  ++W   APMS+ R    +    G +Y +GG
Sbjct: 456 AASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGG 515

Query: 625 HDAPASNHCSRLSD--CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-- 680
                 +H  R  D   VE Y P+ D W++V+P+   +     C L  K+Y+VGGY+   
Sbjct: 516 R----MDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571

Query: 681 HTYLNTVESYDAQRNEWKESM 701
           +     V+ Y+   +EW+  +
Sbjct: 572 NNVTGIVQVYNTDTDEWERDL 592


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score =  245 bits (625), Expect = 1e-64
 Identities = 166/569 (29%), Positives = 268/569 (47%), Gaps = 24/569 (4%)

Query: 143 DTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202
           +T+ S     + +   FH  +H +  L  +    K     DV L AG    P HR VL+A
Sbjct: 7   ETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAA 66

Query: 203 VSDYFAAMFTNDVLEAKQEEVRME-GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACL 261
            S YF AMF++ + E++ + V  +  + P  L  L+ +AY+  + + E+  ESLL A  +
Sbjct: 67  SSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 126

Query: 262 LQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFL 321
           LQ   V D  + FL K L PSNCLG+    DA  C  L   + +  + HF  V ++++F 
Sbjct: 127 LQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFN 186

Query: 322 LLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL 381
            L  + +  L+ SD++   DE  +F A++QWV HD++ R+  L  LL  +RL LLP   L
Sbjct: 187 SLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCL 246

Query: 382 ADLETSSMFTGDLECQKLLM-EAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDA 439
            +  +S       E  KL+M EA++    + +   ++ SP  +PRK+    L  +GG   
Sbjct: 247 QEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGGQTF 305

Query: 440 MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNP 498
           M     I + D +    +    +   R +F  + I  K+YV GGR     ++  V  ++ 
Sbjct: 306 M--CDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDT 363

Query: 499 VGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQ 549
           V + W+   PM   R G G A LE  +Y VGGH   +          L  VE++DP   +
Sbjct: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423

Query: 550 WNYVASMSTPRSTVGVVALNNKLYAIGGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
           W  VA +    S   VV+   KL+  GG       +  ++ +DP  N+W++ A   +   
Sbjct: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483

Query: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668
               A     ++++GG            +    R+D + + W+ +  ++  R +      
Sbjct: 484 YTAAAVLGSQIFIMGG-------DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536

Query: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
           G+KLYVVGGY G     T++ YD   + W
Sbjct: 537 GNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 46/178 (25%), Positives = 80/178 (44%), Gaps = 11/178 (6%)

Query: 431 LYAVGGMDAMKGT---------TTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
           LY VGG  ++ G            +EKYD   N W+ +  +        V     KL+V 
Sbjct: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449

Query: 482 GGRDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
           GG    + + + V+C++P    WT+             A L   ++ +GG   ++  +  
Sbjct: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY 509

Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
            R+D E  QW  +  M+  R +   +A  NKLY +GG  G+   K+++ +DP ++ W+
Sbjct: 510 -RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 28/127 (22%), Positives = 52/127 (40%), Gaps = 2/127 (1%)

Query: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
           L+  GG    +   + ++ YD   N W               AV+ ++++++GG D   T
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504

Query: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
             +   F+     WT +  M+  R           +Y VGG+ G     T++ +DP    
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564

Query: 550 WNYVASM 556
           WN + ++
Sbjct: 565 WNCITTV 571


>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
           sapiens]
          Length = 589

 Score =  243 bits (621), Expect = 3e-64
 Identities = 162/553 (29%), Positives = 273/553 (49%), Gaps = 24/553 (4%)

Query: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218
           FH  ++A+  L  +    +++   DVLL AG+   P HR VL+A S YF AMF+  + E+
Sbjct: 23  FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82

Query: 219 KQEEVRMEG-VDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIK 277
           +  EV  +  + P  L  L+ YAY+  + + E+  ESLL A  +L+   + D C+ FL K
Sbjct: 83  QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142

Query: 278 QLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDI 337
            LHP+NCLG+    DA  CT+L  ++ +  + +F  + KN++FL LP + + +LL S+++
Sbjct: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202

Query: 338 NVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLLADLETSSMFTGDLEC 396
              DE  ++ + + W+ +D++ R   L  LL  +RL LLP   L+ ++    + T   + 
Sbjct: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKS 262

Query: 397 QKLLMEAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNS 455
           ++++ EA++  L + +   ++ S   +PRK T  AL+ +GG   M     +   D +   
Sbjct: 263 KEIVEEAIRCKLKILQNDGVVTSLCARPRK-TGHALFLLGGQTFM--CDKLYLVDQKAKE 319

Query: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNPVGKIWTVMPPMSTHRH 514
            +    +   R +F    I  K+Y+ GGR     ++  V  ++ + + W+   PM   R 
Sbjct: 320 IIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARF 379

Query: 515 GLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
           G G A L+  +Y VGGH   +          L  VE +DP   +W  VA +    S   V
Sbjct: 380 GHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439

Query: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
           V+   KL+A GG   S   L  ++ +D   N+W++ A   +       A     ++++GG
Sbjct: 440 VSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG 499

Query: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
               ++  CS      E Y      W+ V  ++  R +      G+KLYVVGGY G    
Sbjct: 500 DTEFSA--CSAYKFNSETY-----QWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRC 552

Query: 685 NTVESYDAQRNEW 697
            T++ YD   + W
Sbjct: 553 KTLDCYDPTLDVW 565



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 46/178 (25%), Positives = 71/178 (39%), Gaps = 11/178 (6%)

Query: 431 LYAVGGMDAMKGTTT---------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
           LY VGG  A  G            +E YD   N W  +  +        V     KL+  
Sbjct: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449

Query: 482 GGRD-GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
           GG       L  V+C++     WTV             A L   ++ +GG   +S  +  
Sbjct: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAY 509

Query: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
            +++ E  QW  V  ++  R +   VA  NKLY +GG  G    K+++ +DP  + W+
Sbjct: 510 -KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 29/127 (22%), Positives = 51/127 (40%), Gaps = 2/127 (1%)

Query: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
           L+A GG          ++ YD   N W    T          AV+ N+++++GG      
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505

Query: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
            +  + FN     WT +  ++  R           +Y VGG+ G     T++ +DP    
Sbjct: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564

Query: 550 WNYVASM 556
           WN + ++
Sbjct: 565 WNSITTV 571


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,708,620
Number of Sequences: 37866
Number of extensions: 1351633
Number of successful extensions: 4967
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 3470
Number of HSP's gapped (non-prelim): 466
length of query: 720
length of database: 18,247,518
effective HSP length: 110
effective length of query: 610
effective length of database: 14,082,258
effective search space: 8590177380
effective search space used: 8590177380
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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