Search of human proteins with 16933565

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16933565 protocadherin 21 precursor [Homo sapiens]
         (859 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16933565 protocadherin 21 precursor [Homo sapiens]                1714   0.0  
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]      281   2e-75
gi|16933559 protocadherin LKC precursor [Homo sapiens]                264   3e-70
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]            226   5e-59
gi|47059046 dachsous 2 isoform 1 [Homo sapiens]                       223   6e-58
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]           219   9e-57
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]            218   2e-56
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]       212   1e-54
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   206   6e-53
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...   206   6e-53
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]        195   2e-49
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]        195   2e-49
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...   194   2e-49
gi|16933557 dachsous 1 precursor [Homo sapiens]                       191   3e-48
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]           186   1e-46
gi|11056030 protocadherin gamma subfamily A, 2 isoform 1 precurs...   186   1e-46
gi|14196462 protocadherin gamma subfamily A, 2 isoform 2 precurs...   186   1e-46
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s...   179   1e-44
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]        179   1e-44
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]        179   1e-44
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ...   179   1e-44
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]        177   5e-44
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]        177   5e-44
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]        177   5e-44
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]         176   1e-43
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]        176   1e-43
gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precur...   172   9e-43
gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precur...   172   9e-43
gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precurs...   165   2e-40
gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precurs...   165   2e-40

>gi|16933565 protocadherin 21 precursor [Homo sapiens]
          Length = 859

 Score = 1714 bits (4438), Expect = 0.0
 Identities = 859/859 (100%), Positives = 859/859 (100%)

Query: 1   MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGT 60
           MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGT
Sbjct: 1   MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGT 60

Query: 61  DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK 120
           DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK
Sbjct: 61  DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK 120

Query: 121 VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP 180
           VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP
Sbjct: 121 VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP 180

Query: 181 FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240
           FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ
Sbjct: 181 FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240

Query: 241 DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG 300
           DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG
Sbjct: 241 DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG 300

Query: 301 AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360
           AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ
Sbjct: 301 AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360

Query: 361 NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVT 420
           NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVT
Sbjct: 361 NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVT 420

Query: 421 IIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVAR 480
           IIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVAR
Sbjct: 421 IIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVAR 480

Query: 481 IPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEA 540
           IPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEA
Sbjct: 481 IPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEA 540

Query: 541 TARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDA 600
           TARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDA
Sbjct: 541 TARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDA 600

Query: 601 EEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKD 660
           EEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKD
Sbjct: 601 EEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKD 660

Query: 661 RGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLIS 720
           RGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLIS
Sbjct: 661 RGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLIS 720

Query: 721 TATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNN 780
           TATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNN
Sbjct: 721 TATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNN 780

Query: 781 NSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTL 840
           NSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTL
Sbjct: 781 NSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTL 840

Query: 841 ISELKQKFEKKSVHNKAYF 859
           ISELKQKFEKKSVHNKAYF
Sbjct: 841 ISELKQKFEKKSVHNKAYF 859


>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
          Length = 3354

 Score =  281 bits (719), Expect = 2e-75
 Identities = 235/720 (32%), Positives = 349/720 (48%), Gaps = 62/720 (8%)

Query: 8   ALALGLLRLCLAQAN----FAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63
           A  L L+  C  Q N    F  HFFD              + EDTPVGS V  L   D +
Sbjct: 12  AWLLVLISGCWGQVNRLPFFTNHFFDT----------YLLISEDTPVGSSVTQLLAQDMD 61

Query: 64  GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVI 123
            DP+ + +S + ++R  F+V+P  G + L + LDRE + E     S+SD   ++  KV I
Sbjct: 62  NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120

Query: 124 LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAV 183
            V D ND AP F  +PY   +PE+ P G+ IF V+A D D G+GGSV Y  Q     FA+
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180

Query: 184 DRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
           D   G++ +     LDYE ++ + +TV A D            S    + + + DVQDM 
Sbjct: 181 DSARGIVTVI--RELDYETTQAYQLTVNATD-----QDKTRPLSTLANLAIIITDVQDMD 233

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAI 302
           P+F+  PY   +YE + PG+ V  + A+D D+G+P  I Y++V+GN +  F ++  SG +
Sbjct: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVL 293

Query: 303 SIT---QSPAQLQREVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPPTFYGESG 358
           ++         L    + L V+ TE++   +P+ A  T    I ++D+N++ P F     
Sbjct: 294 TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF----- 348

Query: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQ--GANAKFNLQLVGPRG-IFRVVPQTVLN 415
             + + +++ E    G  L  L I V D D+  G N+ F + LVG     F + P +V  
Sbjct: 349 NSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407

Query: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
           +A + I V  +  +D+E      F L A E + P+     A V I L++ NDN P F   
Sbjct: 408 KADIRIRV--AIPLDYETVDRYDFDLFANE-SVPDHV-GYAKVKITLINENDNRPIFSQP 463

Query: 476 YYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWAS 535
            Y   + EN   G+SV+ V A D D G +GEV Y  +    D F +   TGLI     A 
Sbjct: 464 LYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIML--IAR 520

Query: 536 LDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP----- 590
           LD E   R+   + A D  G+ +   V I +LDVND+ P F K      +    P     
Sbjct: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEP-ANVFDINSHTGEIWLKNSIRSLDALHNITPGRD 649
           V++ A DED+  PNN + YSI  A    + FDI+ + G   +  S R LD    I+ G  
Sbjct: 581 VRLRATDEDS-PPNNQITYSIVSASAFGSYFDISLYEGYGVISVS-RPLD-YEQISNG-- 635

Query: 650 CLWSLEVQAKDRGSPSFSTTALLKIDITDAE----TLSRSPMAAFLIQTKDNPMKAVGVL 705
            L  L V A D G+P  ++T  + I++ D      T S+    A+ +   +N M    VL
Sbjct: 636 -LIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK---PAYFVSVVENIMAGATVL 691



 Score =  175 bits (443), Expect = 2e-43
 Identities = 180/656 (27%), Positives = 279/656 (42%), Gaps = 60/656 (9%)

Query: 46   EDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            E  P G  +Y +   D +      +SY +      R  F ++ + G +    ELDRER  
Sbjct: 901  EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVG-MPRMDFLINSSSGVVVTTTELDRERIA 959

Query: 103  EIEAIISISDG---LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
            E +  +  SD           + I V D NDE P F    Y   V ED+P    +  ++ 
Sbjct: 960  EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019

Query: 160  VDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG- 216
             D D G    ++YF+   N+   F+V     V+R   G  LD E +  + + + A D G 
Sbjct: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVG--LDRETTAAYMLILEAIDNGP 1077

Query: 217  -GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDR 275
             G+ H      + T TV V V DV D  P+F+ + Y   V ED   G  +L++ A D D 
Sbjct: 1078 VGKRH------TGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADE 1131

Query: 276  GKPNRILYSLVNGNDG-AFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQ 334
            G+  R+ Y +++GN G  F I+ ++G   + + P  L RE    HV + E         +
Sbjct: 1132 GEFGRVWYRILHGNHGNNFRIHVSNGL--LMRGPRPLDRERNSSHVLIVEAYNHDLGPMR 1189

Query: 335  ATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK 394
            ++V V + + D+N+  P F      Q    L + E    G  +  ++ T  DS  G    
Sbjct: 1190 SSVRVIVYVEDINDEAPVF----TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245

Query: 395  FNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSS 454
            + + L G  G F +      +E+   II  N   +D+E        + A +   P     
Sbjct: 1246 YRI-LSGAEGKFEI------DESTGLIITVN--YLDYETKTSYMMNVSATD-QAPPFNQG 1295

Query: 455  TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGT 514
               V I LL+  D   +F +  Y A I EN   G+ +V V A   D       +++ Y +
Sbjct: 1296 FCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355

Query: 515  --GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY-SVAEVFITLLDVND 571
                 LF I   TG+I  Q    +D E    Y   V A+D   K  S  +V+IT+LD ND
Sbjct: 1356 TQAKALFKIDAITGVITVQ--GLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDEND 1413

Query: 572  HPPQF------GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI--- 622
            + P+F        S+ +   V      ++A D DA   N  V +S+     A  F+I   
Sbjct: 1414 NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTT 1472

Query: 623  NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
            N   GE+++   +   +  H I         L+V A DRG+P      +L++ I D
Sbjct: 1473 NDSIGEVFVARPLDREELDHYI---------LQVVASDRGTPPRKKDHILQVTILD 1519



 Score =  173 bits (439), Expect = 5e-43
 Identities = 168/587 (28%), Positives = 260/587 (44%), Gaps = 51/587 (8%)

Query: 36   NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDP 85
            N N  +FS P       E+  VG+ V T+  TD +      +SY  S DP     FS+D 
Sbjct: 454  NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FSLDK 510

Query: 86   TFGNITLVEELDREREDEIE-AIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALV 144
              G I L+  LD E        II+   G      +V I V D ND  P F ++ YV  +
Sbjct: 511  DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570

Query: 145  PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH---SPFAVDRHSGVLRLQAGATLDYE 201
             E+ P+ + + ++ A D D+     +TY + +     S F +  + G   +     LDYE
Sbjct: 571  RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630

Query: 202  RSRTH--YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDT 259
            +      Y+TV+A D G      +   ++T  VT+ V D  D  P F    Y+  V E+ 
Sbjct: 631  QISNGLIYLTVMAMDAG------NPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684

Query: 260  LPGSEVLKVVAMDGDRGKP---NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVY 316
            + G+ VL + A D DR +      I+YSL       F IN  SG I+ T   + L RE  
Sbjct: 685  MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTT---SLLDRETK 739

Query: 317  ELHVQVTEMSPAGSPAAQAT--VPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG 374
              ++ +      G    Q T    V I ++D+N++ PT+       N  E++    PP  
Sbjct: 740  SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT----PPDS 795

Query: 375  EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKS 434
            ++   + +   D D G N      +  P   + +   T   + + T  + +    D  ++
Sbjct: 796  DVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTT--GKIRTTHAMLDRENPDPHEA 850

Query: 435  KVLTFKLLAVEV--NTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
            +++   +++V      P K +S+A V + LLD NDN P F +L +VA + E  P G S+ 
Sbjct: 851  ELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIY 910

Query: 493  AVTAVDPDTGPWGEVKY-STYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAE 551
             V A+D D G  G V Y    G     FLI+ S+G++ T     LD E  A Y   V A 
Sbjct: 911  QVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT--TELDRERIAEYQLRVVAS 968

Query: 552  D--MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAI 596
            D     K S + + I +LDVND  P F  +V   ++    P +   +
Sbjct: 969  DAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015



 Score =  167 bits (424), Expect = 3e-41
 Identities = 164/599 (27%), Positives = 269/599 (44%), Gaps = 54/599 (9%)

Query: 79   SVFSVDPTFGNITLVEELDRE-REDEIEAIISISDGLNLVAEK------VVILVTDANDE 131
            + F +D   G IT  +ELD E        I++ +D   +++ +      V++ V D ND 
Sbjct: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740

Query: 132  APRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH--SPFAVDRHSGV 189
             P F ++        +   G  ++   A DRD+G  G V Y + +      F +    GV
Sbjct: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800

Query: 190  LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT 249
            LR++    LD E    + +T+ A+D G          S+T  V + V D+ D  PV +  
Sbjct: 1801 LRVRKDVELDRETIAFYNLTICARDRGMP------PLSSTMLVGIRVLDINDNDPVLLNL 1854

Query: 250  PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSP 308
            P    + E++   S V  V+A D D G   R+ +++  GN + AF IN T+G +++ +  
Sbjct: 1855 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPL 1914

Query: 309  AQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMN 368
             + +   Y+L + V +       A +    + I + D N++ P F      ++ ++  + 
Sbjct: 1915 DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLF-----TKSTYQAEVM 1969

Query: 369  EHPPQGEILRGLK--ITVNDSDQGANAKFNLQLVGPR-GIFRVVPQTVLNEAQVTIIVEN 425
            E+ P G  L  L   I   D+DQ   A    QL+G + G+F +   T +   +  +I++ 
Sbjct: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029

Query: 426  SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENA 485
             A        +L   LLA ++      +STA ++I +LD NDN P F        + EN 
Sbjct: 2030 EAF----SPPILELLLLAEDIGL---LNSTAHLLITILDDNDNRPTFSPATLTVHLLENC 2082

Query: 486  PGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYN 545
            P G SV+ VTA D D+G  GE+ Y       D FLIH  TG+I     A++D E    Y 
Sbjct: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGN-ATIDREEQESYR 2141

Query: 546  FYVKAEDMEGKYSVAEVFITLL--DVNDHPPQFGKSVQKKTMV----LGTPV-KIEAIDE 598
              V A D           +T+L  D+ND  P+F   +Q  +++     GT +  I AID 
Sbjct: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201

Query: 599  DAEEPNNLVDYSITH-----------AEPANVFDINSHTGEIWLKNSI-RSLDALHNIT 645
            D    N  ++Y I                 + F +N +TG + +K+ + R L A + +T
Sbjct: 2202 DL---NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257



 Score =  160 bits (405), Expect = 5e-39
 Identities = 147/524 (28%), Positives = 234/524 (44%), Gaps = 59/524 (11%)

Query: 121  VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP 180
            V + + D ND  P F Q  Y   V ED+P G+II  V A D D+G+   + Y L +  S 
Sbjct: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447

Query: 181  FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240
            FA++  +G + + +  +LD E+   + +T +AKD  G +  A      +  V + V DV 
Sbjct: 2448 FAINPTTGDIYVLS--SLDREKKDHYILTALAKDNPGDV--ASNRRENSVQVVIQVLDVN 2503

Query: 241  DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG 300
            D  P F    +   VYE+   G+ V+ ++A D D G    + YSL      AF ++  SG
Sbjct: 2504 DCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG 2563

Query: 301  AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360
             ++ TQ P Q   E + L V  T+    G P    T  + + ++D+N++ P F     P 
Sbjct: 2564 LVT-TQRPLQ-SYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRPVFVR---PP 2615

Query: 361  NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG-----IFRVVPQTVLN 415
            N   L + E  P    +   ++   D D+G N       +   G      F + P     
Sbjct: 2616 NGTILHIREEIPLRSNV--YEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP----- 2668

Query: 416  EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF--- 472
               ++ +++ +  +D E   V +  L+A ++  P  + +   + + L D +DN P F   
Sbjct: 2669 ---ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725

Query: 473  ---DSLYYVARIPENAPGGSSVVAVT-AVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGL 527
                  Y +  +PE++P G+ V  VT AVD D GP   V Y    G     F + P   L
Sbjct: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2785

Query: 528  IYTQPWASLDAEATARYNFYVKAE---------------DMEGKYSVAEVFITLLDVNDH 572
            +  +    LD E  A ++F VKA                D+    ++ EV + L D+ND 
Sbjct: 2786 LVLR---DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842

Query: 573  PPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 611
            PP+F K+     V     V    +++ A+D D    N+LV YSI
Sbjct: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN-NSLVFYSI 2885



 Score =  158 bits (400), Expect = 2e-38
 Identities = 178/696 (25%), Positives = 285/696 (40%), Gaps = 65/696 (9%)

Query: 11   LGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE---GDPI 67
            LG +R  +    +     D     T    +   L E   +G+ V  +  TD +   G  +
Sbjct: 1185 LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLV 1244

Query: 68   SYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG---LNLVAEKVVIL 124
            +Y I         F +D + G I  V  LD E +      +S +D     N     V I 
Sbjct: 1245 NYRIL--SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302

Query: 125  VTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP---- 180
            + +  DEA +F    Y A + E++  G+ I +V A   D  +   +TY      S     
Sbjct: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKA 1360

Query: 181  -FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDV 239
             F +D  +GV+ +Q    +D E+   + +TVVA DGG ++        +T  V + V D 
Sbjct: 1361 LFKIDAITGVITVQG--LVDREKGDFYTLTVVADDGGPKV-------DSTVKVYITVLDE 1411

Query: 240  QDMAPVFVGTPYYGY-VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINE 297
             D +P F  T      + ED   G  V  V A D D G   ++++SL +GN  GAFEI  
Sbjct: 1412 NDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471

Query: 298  TSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES 357
            T+ +I        L RE  + ++     S  G+P  +    + + I+D+N++PP      
Sbjct: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531

Query: 358  GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            G    + +S+NE+   G  +  +++   D D G N+  +  +             +  E 
Sbjct: 1532 G----YNVSVNENVGGGTAV--VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE- 1584

Query: 418  QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
                I    A  D E+           +  TP   S+T  V + ++D NDN P F   +Y
Sbjct: 1585 ----IATRPAPPDRERQSFYHLVATVEDEGTP-TLSATTHVYVTIVDENDNAPMFQQPHY 1639

Query: 478  VARIPENAPG-GSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWAS 535
               + E      +S++ + A+D D GP G V Y+   G   + F I    G+I       
Sbjct: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAA--KE 1697

Query: 536  LDAEAT-ARYNFYVKAEDM-----EGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVL-- 587
            LD E +  RY   V A D          S   V + + D+ND+ P F +  +    V   
Sbjct: 1698 LDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEG 1757

Query: 588  --GTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI---RSLDALH 642
              G  V      +    PN  V+YSI   +P   F I+   G + ++  +   R   A +
Sbjct: 1758 QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817

Query: 643  NITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
            N+T          + A+DRG P  S+T L+ I + D
Sbjct: 1818 NLT----------ICARDRGMPPLSSTMLVGIRVLD 1843



 Score =  154 bits (388), Expect = 4e-37
 Identities = 180/717 (25%), Positives = 298/717 (41%), Gaps = 87/717 (12%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDP---TFGNITLVEELD 97
            L E+ P G  V  +  TD +      + Y I      R +  +       GN T+    D
Sbjct: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATI----D 2133

Query: 98   REREDEIEAIISISDGLNLVAEK---VVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154
            RE ++     +  +D   +       V IL+ D ND  P F+       V E    G++I
Sbjct: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVI 2193

Query: 155  FKVHAVDRDTG-----------SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERS 203
              + A+D D             +       + N    FAV+ ++G + +++   ++ E  
Sbjct: 2194 ANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELV 2251

Query: 204  RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF--VGTPYY-GYVYEDTL 260
             T+ +T+   D    L    V       +TVNV DV D  P F   G  YY   + E   
Sbjct: 2252 ATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGAT 2310

Query: 261  PGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHV 320
            PG+ ++ V A+D D+G    + Y+L++     +   E S A  +  +      EV+ L+ 
Sbjct: 2311 PGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF 2370

Query: 321  QVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGL 380
             V   S  GSP   A +PV + IVD+N++ P F      Q  ++ ++ E  P G I+  L
Sbjct: 2371 TV-RASDNGSPPRAAEIPVYLEIVDINDNNPIF-----DQPSYQEAVFEDVPVGTII--L 2422

Query: 381  KITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFK 440
             +T  D+D G  A     L      F + P T      + ++    +++D EK     + 
Sbjct: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTT----GDIYVL----SSLDREKKD--HYI 2472

Query: 441  LLAVEVNTPEKFSS-----TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVT 495
            L A+  + P   +S     +  VVIQ+LD ND  P+F    +   + EN P G+SV+ + 
Sbjct: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532

Query: 496  AVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--M 553
            A D D GP GE+ YS  G G + F +   +GL+ TQ       ++  +++  V A D   
Sbjct: 2533 ATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQ----RPLQSYEKFSLTVVATDGGE 2588

Query: 554  EGKYSVAEVFITLLDVNDHPPQFGK-------SVQKKTMVLGTPVKIEAIDEDAEEPNNL 606
               +    + + ++DVND+ P F +        ++++  +     ++ A D+D E  N  
Sbjct: 2589 PPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGA 2647

Query: 607  VDYSITHAEPANVFDINSHTGEIWLKNSIRSL-DALHNITPGRDCLWSLEVQAKDRGSP- 664
            V YS             +   E ++ + I  L      +      ++SL + A D G P 
Sbjct: 2648 VRYSFLKT-------AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700

Query: 665  SFSTTALLKI---DITDAETL-----SRSPMAAFLIQTKDNPMKAVGVLAGTMATVV 713
             + T   L++   DI D E L       SP    L   + +P    G L G +   V
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR---GTLVGNVTGAV 2754



 Score =  150 bits (378), Expect = 6e-36
 Identities = 181/665 (27%), Positives = 297/665 (44%), Gaps = 67/665 (10%)

Query: 43   SLPEDTPVGSHVYTLNGTD-PEGD--PISYHISFDPSTRSVFSVDPTFGNITL-VEELDR 98
            S+PED P G  +  L  TD  EG+   + Y I    +  + F +  + G +      LDR
Sbjct: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRI-LHGNHGNNFRIHVSNGLLMRGPRPLDR 1168

Query: 99   EREDEIEAIISISD---GLNLVAEKVVILVTDANDEAPRFIQEPYVAL-VPEDIPAGSII 154
            ER      I+   +   G    + +V++ V D NDEAP F Q+ Y  L + E    G+ +
Sbjct: 1169 ERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSV 1228

Query: 155  FKVHAVDRDTGSGGSVTY-FLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
              V A DRD+G GG V Y  L      F +D  +G+  +     LDYE   ++ + V A 
Sbjct: 1229 IVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGL--IITVNYLDYETKTSYMMNVSAT 1286

Query: 214  DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG 273
            D       A        +V + + +  D A  F    Y   + E+   G+E+++V A   
Sbjct: 1287 D------QAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSI 1340

Query: 274  DRGKPNRILYSL----VNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
            D    N+I Y             F+I+  +G I++     + + + Y L    T ++  G
Sbjct: 1341 D--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL----TVVADDG 1394

Query: 330  SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
             P   +TV V I ++D N++ P F   S       +S+ E  P G+ +  +K    D+  
Sbjct: 1395 GPKVDSTVKVYITVLDENDNSPRFDFTSDS----AVSIPEDCPVGQRVATVKAWDPDAGS 1450

Query: 390  GANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
                 F+L      G F +V     N++   + V  +  +D E+      +++A +  TP
Sbjct: 1451 NGQVVFSLASGNIAGAFEIV---TTNDSIGEVFV--ARPLDREELDHYILQVVASDRGTP 1505

Query: 450  EKFSSTADVVIQ--LLDTNDNVPKFDSLY-YVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
             +     D ++Q  +LD NDN P  +S + Y   + EN  GG++VV V A D D G    
Sbjct: 1506 PR---KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV 1562

Query: 507  VK-YSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVA---EV 562
            +  Y T G     F +   +G I T+P A  D E  + Y+     ED EG  +++    V
Sbjct: 1563 LSYYITEGNKDMAFRMDRISGEIATRP-APPDRERQSFYHLVATVED-EGTPTLSATTHV 1620

Query: 563  FITLLDVNDHPPQFGKSVQKKTMVLG------TPVKIEAIDEDAEEPNNLVDYSITHAEP 616
            ++T++D ND+ P F +   +  +  G      + + I+A+D D E PN  V Y+I     
Sbjct: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-EGPNGTVTYAIVAGNI 1679

Query: 617  ANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRG---SPSFSTTALLK 673
             N F I+ H G I    + + LD  + I+ GR   ++L V A D+    S   ++T  + 
Sbjct: 1680 VNTFRIDRHMGVI---TAAKELD--YEISHGR---YTLIVTATDQCPILSHRLTSTTTVL 1731

Query: 674  IDITD 678
            +++ D
Sbjct: 1732 VNVND 1736



 Score =  143 bits (361), Expect = 6e-34
 Identities = 147/513 (28%), Positives = 228/513 (44%), Gaps = 62/513 (12%)

Query: 36   NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFG 88
            N N  +F  P       ED PVG+ + T+  TD +    +          S F+++PT G
Sbjct: 2396 NDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTG 2455

Query: 89   NITLVEELDREREDEIEAIISISDGLNLVAE-------KVVILVTDANDEAPRFIQEPYV 141
            +I ++  LDRE++D         D    VA        +VVI V D ND  P+F +  + 
Sbjct: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515

Query: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH-SPFAVDRHSGVLRLQAGATLDY 200
              V E+ PAG+ +  + A D+D G  G +TY L+      F VD  SG++  Q      Y
Sbjct: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ-SY 2574

Query: 201  ERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG--YVYED 258
            E+     +TVVA DGG      +     TT + V V DV D  PVFV  P     ++ E+
Sbjct: 2575 EKFS---LTVVATDGG------EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625

Query: 259  TLPGSEVLKVVAMDGDRGKPNRILYSLV----NGNDGAFEINETSGAISITQSPAQLQRE 314
                S V +V A D D G    + YS +    N +   F I+  SG I   Q   +L RE
Sbjct: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ---RLDRE 2682

Query: 315  VYELHVQVTEMSPAGSPAAQATV-PVTIRIVDLNNHPPTFYG--ESGPQNRFELSMNEHP 371
               ++  +   S  G P    T+ P+ + + D++++ P F    +  PQ +  L++ EH 
Sbjct: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHS 2741

Query: 372  PQGEILRGLKITVNDSDQGANA--KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI 429
            P+G ++  +   V D+D+G NA   + +        F + P   L      +++ +   +
Sbjct: 2742 PRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGCL------LVLRD---L 2791

Query: 430  DFEKSKVLTFKLLAVEVNT---PEKFSSTADVVIQLL---------DTNDNVPKFDSLYY 477
            D E+  + +F + A    +   P   S T D+V  L          D ND  P+F    Y
Sbjct: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851

Query: 478  VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS 510
             A +  +A  GS ++ V A+D D G    V YS
Sbjct: 2852 TAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884



 Score =  135 bits (341), Expect = 1e-31
 Identities = 181/689 (26%), Positives = 292/689 (42%), Gaps = 75/689 (10%)

Query: 46  EDTPVGSHVYTLNGTDPE-GDP--ISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
           E +P G+ V  +   D + G P  I Y I    +T S+F++D   G +TL   LDRE   
Sbjct: 247 EHSPPGTTVRIITAIDQDKGRPRGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPL 305

Query: 103 EIEAIISISDGLNL----------VAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG- 151
                I    G  L          V     ILV D ND AP F    Y   + E    G 
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365

Query: 152 SIIFKVHAVDRDTGSGGSVTYFL----QNLH----SPFAVDRHSGVLRLQAGATLDYERS 203
           ++   +  VD+D   G +  + +     N H    SP +V   + + R++    LDYE  
Sbjct: 366 ALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADI-RIRVAIPLDYETV 424

Query: 204 RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGS 263
             +   + A +        D V  A   +T+  E+  D  P+F    Y   +YE+   G+
Sbjct: 425 DRYDFDLFANESV-----PDHVGYAKVKITLINEN--DNRPIFSQPLYNISLYENVTVGT 477

Query: 264 EVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVT 323
            VL V+A D D G    + Y   +  D  F +++ +G I +      + R  YEL  + T
Sbjct: 478 SVLTVLATDNDAGTFGEVSYFFSDDPD-RFSLDKDTGLIML------IARLDYELIQRFT 530

Query: 324 EMSPAGSPAAQATVP-VTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKI 382
               A     + T   V I ++D+N++ PTF  ++     +  ++ E+ P    L  L+ 
Sbjct: 531 LTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDA-----YVGALRENEPSVTQLVRLRA 585

Query: 383 TVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEK--SKVLTFK 440
           T  DS       +++      G +  +    L E    I V  S  +D+E+  + ++   
Sbjct: 586 TDEDSPPNNQITYSIVSASAFGSYFDIS---LYEGYGVISV--SRPLDYEQISNGLIYLT 640

Query: 441 LLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD 500
           ++A++   P   +ST  V I++ D NDN P F    Y   + EN   G++V+ + A D D
Sbjct: 641 VMAMDAGNPP-LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLD 699

Query: 501 TG-PWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED----MEG 555
               +G+        G+  F I+  +G I T   + LD E  + Y   V+A D       
Sbjct: 700 RSREYGQESIIYSLEGSTQFRINARSGEITTT--SLLDRETKSEYILIVRAVDGGVGHNQ 757

Query: 556 KYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDYS 610
           K  +A V ITLLD+ND+ P +  +     +V  TP       + A+D D  E   LV YS
Sbjct: 758 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLV-YS 816

Query: 611 ITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSP-----S 665
           I    P   + +NS TG+I  + +   LD  +      + +  + V   D G P     S
Sbjct: 817 I--QPPNKFYSLNSTTGKI--RTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATS 872

Query: 666 FSTTALLKIDITDAE-TLSRSPMAAFLIQ 693
            +T  +  +D+ D + T    P  A +++
Sbjct: 873 SATVFVNLLDLNDNDPTFQNLPFVAEVLE 901



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 74/276 (26%), Positives = 116/276 (42%), Gaps = 32/276 (11%)

Query: 38   NMALFSLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRS--VFSVDPTFGNITL 92
            N  +  + E+ P+ S+VY +  TD +      + Y        R    F +DP  G I  
Sbjct: 2616 NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQT 2675

Query: 93   VEELDREREDEIEAIISISDGLNLVAEKVV----ILVTDANDEAPRFIQEP------YVA 142
             + LDRE +     I+  SD    V  + +    + + D +D  P F++ P       + 
Sbjct: 2676 AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLL 2735

Query: 143  LVPEDIPAGSIIFKVH-AVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLD 199
             VPE  P G+++  V  AVD D G    V YF+   N    F +     +L L+     D
Sbjct: 2736 TVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----D 2790

Query: 200  YERSRTHYITVVAKDGGGRLHGA--------DVVFSATTT-VTVNVEDVQDMAPVFVGTP 250
             +R R    + + K    R            D+V   T   V V +ED+ D  P F    
Sbjct: 2791 LDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850

Query: 251  YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLV 286
            Y   V  D   GSE+++V+A+D D G  + + YS++
Sbjct: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 20/157 (12%)

Query: 41   LFSLPEDTPVGSHVYTLNGT---DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELD 97
            L ++PE +P G+ V  + G    D   + I Y+     +    F + P  G + ++ +LD
Sbjct: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLD 2792

Query: 98   REREDEIEAIISISDG------------LNLVAE----KVVILVTDANDEAPRFIQEPYV 141
            RERE     I+  S              L+LVA+    +V +++ D ND+ PRF +  Y 
Sbjct: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852

Query: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH 178
            A V  D   GS + +V A+D D G+   V Y +  +H
Sbjct: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIH 2889


>gi|16933559 protocadherin LKC precursor [Homo sapiens]
          Length = 1310

 Score =  264 bits (674), Expect = 3e-70
 Identities = 219/724 (30%), Positives = 336/724 (46%), Gaps = 66/724 (9%)

Query: 21  ANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSV 80
           AN AP F          NM    LPED PVG+  + L   D + DP++Y +S        
Sbjct: 20  ANVAPKFL--------ANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMS--GPNAYF 69

Query: 81  FSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPY 140
           F+V P  G + L   LD E     +  IS+SD    V  +++++V D ND AP F    +
Sbjct: 70  FAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF 129

Query: 141 VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQA------ 194
              + E +P GS++F V AVD+D GS G V Y ++ +        H  + R+ A      
Sbjct: 130 STSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH--LFRILANGSIVL 187

Query: 195 GATLDYERSRTHY-ITVVAKDGGGRLHGA-DVVFSATTTVTVNVEDVQDMAPVFVGTPYY 252
             +L Y      Y + + A D GG  H    +  S    ++++V D  D+ P FV   Y 
Sbjct: 188 NGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYS 247

Query: 253 GYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVN---------GNDGAFEINETSGAIS 303
             V ED   G+ VL V A+DGD+G  + ++YS+           G DG   +N +     
Sbjct: 248 ASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQ 307

Query: 304 ITQSPAQLQREV--YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGP-- 359
           + ++  ++Q +V   E H+ +          A+ ++ VT+R++D+N+H P FY  S P  
Sbjct: 308 LLEADEEVQLQVTATETHLNIY------GQEAKVSIWVTVRVMDVNDHKPEFYNCSLPAC 361

Query: 360 -------QNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG-IFRVVPQ 411
                  Q  F   ++EH      +  L + V D D+G+N  F L L GP    F V P+
Sbjct: 362 TFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421

Query: 412 TVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPK 471
                A V ++V  SA +D+E+   +  +++A + +  + F S A V I L D ND+ P 
Sbjct: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATD-SVSQNF-SVAMVTIHLRDINDHRPT 479

Query: 472 FDSLYYVARIPENAPGGSSVV-AVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIY 529
           F    YV  +PE++  GS V  ++ A DPDTG WG++ YS   G GADLF + P +G + 
Sbjct: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVT 539

Query: 530 TQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKS----VQKKTM 585
            +    LD E+ A Y   ++A D     S   + I LLD+ND+ P    S    VQ++  
Sbjct: 540 VRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEG 599

Query: 586 VLGTPVKIEAIDEDAEEPNN-LVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNI 644
                V I+A D D    NN  + +++     ++ F ++  TG   L  ++  LD    I
Sbjct: 600 --NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTG---LLRNLGPLDR-EAI 653

Query: 645 TPGRDCLWSLEVQAKDRGSPSFSTTALLKI---DITDAETLSRSPMAAFLIQTKDNPMKA 701
            P  +    L V   D G P   T   + I   DI D   +       F ++ +D P   
Sbjct: 654 DPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEED-PGVL 712

Query: 702 VGVL 705
           VGV+
Sbjct: 713 VGVV 716



 Score =  148 bits (374), Expect = 2e-35
 Identities = 176/691 (25%), Positives = 297/691 (42%), Gaps = 87/691 (12%)

Query: 45   PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEI 104
            P+    G+ + +L G D E   +S      P   +  +       ++ + + +R+    +
Sbjct: 396  PDKGSNGTFLLSLGGPDAEAFSVS------PERAAGSASVQVLVRVSALVDYERQTAMAV 449

Query: 105  EAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF-KVHAVDRD 163
            + + + S   N     V I + D ND  P F Q  YV  VPE    GS++   +HA D D
Sbjct: 450  QVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPD 509

Query: 164  TGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHG 221
            TG+ G +TY L   N    F VD  SG + ++ G  LD E    +Y+T+ A DGG     
Sbjct: 510  TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---- 565

Query: 222  ADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPN-- 279
                 S++TT+ +++ D+ D APV  G+ Y  +V E+   G+  + + A D D    N  
Sbjct: 566  ----LSSSTTLQIHLLDINDNAPVVSGS-YNIFVQEEE--GNVSVTIQAHDNDEPGTNNS 618

Query: 280  RILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQ-----VTEMSPAGSPAA 333
            R+L++L+ G     F ++  +G +   ++   L RE  +  ++        +S  G P  
Sbjct: 619  RLLFNLLPGPYSHNFSLDPDTGLL---RNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL 675

Query: 334  QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQG-AN 392
               V VTI + D+N++ P F      Q+ +  ++ E  P   +L G+ +   D+DQ  AN
Sbjct: 676  GTKVNVTITVEDINDNLPIFN-----QSSYNFTVKEEDPG--VLVGV-VKAWDADQTEAN 727

Query: 393  AKFNLQLVGPRGIFRVVPQTVLNE--AQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPE 450
             + +  L G    + ++   VL    A+  + +    ++D+E   V    + A E   P+
Sbjct: 728  NRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA-ENPDPQ 786

Query: 451  KFSSTADVVIQLLDTNDNVPKFD--SLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
               +  DV + + D NDN P  D  SL  + R+ EN      V  V A D DT    E++
Sbjct: 787  GGETIVDVCVNVKDVNDNPPTLDVASLRGI-RVAENGSQHGQVAVVVASDVDTSAQLEIQ 845

Query: 509  YSTY---GTGADL------FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM------ 553
                     G D+      +    + G +Y     ++D EA       V+A D+      
Sbjct: 846  LVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF 905

Query: 554  EGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVL--------GTPVKIEAIDEDAEEPNN 605
            +   +   + IT+ DVND+ P F    + KT V+             + A D+D+   N 
Sbjct: 906  QAYSNNGSLLITIEDVNDNAPYF--LPENKTFVIIPELVLPNREVASVRARDDDSGN-NG 962

Query: 606  LVDYSITHAEPAN----------VFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLE 655
            ++ +SI   +  +          VF I + +       SI+ + +L +   G    + + 
Sbjct: 963  VILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQG---TYQVT 1019

Query: 656  VQAKDRGS--PSFSTTALLKIDITDAETLSR 684
            VQA+DR S  P    T  L +   D    SR
Sbjct: 1020 VQARDRPSLGPFLEATTTLNLFTVDQSYRSR 1050



 Score =  125 bits (315), Expect = 1e-28
 Identities = 161/592 (27%), Positives = 257/592 (43%), Gaps = 94/592 (15%)

Query: 43  SLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
           S+ ED   G+ V T+   D +    DP+ Y IS+  STR  +      G I +   LDRE
Sbjct: 249 SVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISY--STRPGWFDIGADGVIRVNGSLDRE 306

Query: 100 R----EDEIEAIISISDG-LNLVAEK------VVILVTDANDEAPRFIQ--EPYVALVPE 146
           +    ++E++  ++ ++  LN+  ++      V + V D ND  P F     P     PE
Sbjct: 307 QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPE 366

Query: 147 D----------------IPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP----FAV--D 184
           +                IP   +   V+  D D GS G+   FL +L  P    F+V  +
Sbjct: 367 EAQVNFTGYVDEHASPRIPIDDLTMVVY--DPDKGSNGT---FLLSLGGPDAEAFSVSPE 421

Query: 185 RHSGVLRLQA----GATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240
           R +G   +Q      A +DYER     + VVA D   +         +   VT+++ D+ 
Sbjct: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNF-------SVAMVTIHLRDIN 474

Query: 241 DMAPVFVGTPYYGYVYEDTLPGSEVLKVV-AMDGDRGKPNRILYSLVNGNDG-AFEINET 298
           D  P F  + Y   V E +  GS V   + A D D G   +I YSL+ GN    F+++  
Sbjct: 475 DHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPV 534

Query: 299 SGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESG 358
           SG +++      L RE   ++    + +  G+ ++  T+   I ++D+N++ P   G   
Sbjct: 535 SGTVTVRNGEL-LDRESQAVYYLTLQATDGGNLSSSTTLQ--IHLLDINDNAPVVSGS-- 589

Query: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK--FNLQLVGPRGI-FRVVPQTVLN 415
               + + + E   +G +   ++   ND     N++  FNL L GP    F + P T L 
Sbjct: 590 ----YNIFVQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNL-LPGPYSHNFSLDPDTGLL 642

Query: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
                +  E   AID      +   +L  +   P    +  +V I + D NDN+P F+  
Sbjct: 643 RNLGPLDRE---AIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIFNQS 698

Query: 476 YYVARIPENAPGGSSVVAVTAVDPD-TGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWA 534
            Y   + E  PG   V  V A D D T     + +S  G+GA+ F+I    GL+    WA
Sbjct: 699 SYNFTVKEEDPG-VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIR---GLVLGAGWA 754

Query: 535 ----------SLDAEATARYNFYVKAE--DMEGKYSVAEVFITLLDVNDHPP 574
                     SLD E    +N  V AE  D +G  ++ +V + + DVND+PP
Sbjct: 755 EGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPP 806



 Score =  107 bits (266), Expect = 6e-23
 Identities = 145/605 (23%), Positives = 254/605 (41%), Gaps = 86/605 (14%)

Query: 123 ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDT-----GSGGSVTYFLQNL 177
           ++V+ A + AP+F+      ++PED+P G+  F + A D+D      G  G   YF    
Sbjct: 14  LVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYF---- 69

Query: 178 HSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVE 237
              FAV   +G ++L   + LDYE   T  +T+           +D        + V VE
Sbjct: 70  ---FAVTPKTGEVKL--ASALDYETLYTFKVTISV---------SDPYIQVQREMLVIVE 115

Query: 238 DVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSL------VNGNDG 291
           D  D APVF  T +   + E    GS V  V+A+D D G    ++YS+         ++ 
Sbjct: 116 DRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175

Query: 292 AFEINETSGAISITQSPAQLQREV-YELHVQVTEMSPA--GSPAAQATVPV--TIRIVDL 346
            F I   +G+I +  S +   +   Y+L ++  ++      +   Q ++PV  +I +VD 
Sbjct: 176 LFRI-LANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQ 234

Query: 347 NNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN--AKFNLQLVGPRG 404
            +  P F  E      +  S+ E   +G  +  L +   D D+G N    +++      G
Sbjct: 235 PDLDPQFVREF-----YSASVAEDAAKGTSV--LTVEAVDGDKGINDPVIYSISYSTRPG 287

Query: 405 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNT-PEKFSSTADVVIQLL 463
            F +    V+   +V   ++    ++ ++   L        +N   ++   +  V ++++
Sbjct: 288 WFDIGADGVI---RVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVM 344

Query: 464 DTNDNVPKF--------------DSLYYVARIPENAPGGSSVVAVTAV--DPDTGPWGEV 507
           D ND+ P+F                + +   + E+A     +  +T V  DPD G  G  
Sbjct: 345 DVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTF 404

Query: 508 KYSTYGTGADLFLIHPSTGL------IYTQPWASLDAE-ATARYNFYVKAEDMEGKYSVA 560
             S  G  A+ F + P          +  +  A +D E  TA     V  + +   +SVA
Sbjct: 405 LLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVA 464

Query: 561 EVFITLLDVNDHPPQFGKSVQKKTM----VLGTPV--KIEAIDEDAEEPNNLVDYSITHA 614
            V I L D+NDH P F +S+   T+      G+ V   I A D D       + YS+   
Sbjct: 465 MVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQ-ITYSLLPG 523

Query: 615 EPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLK- 673
             A++F ++  +G + ++N          +      ++ L +QA D G+ S STT  +  
Sbjct: 524 NGADLFQVDPVSGTVTVRNG-------ELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL 576

Query: 674 IDITD 678
           +DI D
Sbjct: 577 LDIND 581


>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
          Length = 4557

 Score =  226 bits (577), Expect = 5e-59
 Identities = 197/683 (28%), Positives = 318/683 (46%), Gaps = 55/683 (8%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDPI----SYHISF-DPSTRSVFSVDPTFGNITLVEELD 97
            ++ E  P G  V  L+  D +   +    SYHI+  +P  R    +  +   + +   LD
Sbjct: 2932 NVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLD 2991

Query: 98   REREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
            RE +D     I+ +DGL +    V + V+D ND +P   Q  Y AL+PEDIP+  II KV
Sbjct: 2992 REEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKV 3051

Query: 158  HAVDRDTGSGGSVTYFLQNL-HSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
             A D D GS G + Y L    +S F +D  SG L+  A   LD ER   + +   A DGG
Sbjct: 3052 SAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLA--LLDRERIPVYSLMAKATDGG 3109

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
            GR           + + + +EDV D  PVF    Y   VYE+T   + + +V A+D D G
Sbjct: 3110 GRF--------CQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIG 3161

Query: 277  KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQAT 336
               +++YSL +   G F I+ +SG I + Q   + Q+  Y + V+ T+ SP  S ++  T
Sbjct: 3162 INRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTT 3221

Query: 337  VPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFN 396
              VTI ++D+N++PP F      +  + +++ E    G  +  +  T  D    A   + 
Sbjct: 3222 --VTITVLDINDNPPVF-----ERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYL 3274

Query: 397  LQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTA 456
            ++    +G F++ P+T      +++    S  +D+E  K     + A +  TP   S+ A
Sbjct: 3275 IRSGNEQGKFKINPKT----GGISV----SEVLDYELCKRFYLVVEAKDGGTP-ALSAVA 3325

Query: 457  DVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTG 515
             V I L D NDN PKF    Y A I E+A  G SV+ + A D D+ P G++ +S   G  
Sbjct: 3326 TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR 3385

Query: 516  ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHP 573
             + F + P  GL+  +    LD E  + Y+  V+A D  +    S A V I + DVND+ 
Sbjct: 3386 DNEFTVDPVLGLVKVK--KKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNS 3443

Query: 574  PQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGE 628
            P F  +     +Q+   V  + +++   D D+        +SI        F ++ H   
Sbjct: 3444 PVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPH--- 3500

Query: 629  IWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRS--P 686
                  +RS     +        + L VQAKD G P   +   +++ + +  T   +  P
Sbjct: 3501 ----GILRSAVVFQHT---ESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIP 3553

Query: 687  MAAFLIQTKDN-PMKAVGVLAGT 708
            +  F++  +D+ P   +G +  T
Sbjct: 3554 LEIFIVTMEDDFPGGVIGKIHAT 3576



 Score =  197 bits (500), Expect = 5e-50
 Identities = 193/689 (28%), Positives = 312/689 (45%), Gaps = 62/689 (8%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            ++ ED PVG+++  +   D +      + + IS D +T S F++D   G + ++  +DRE
Sbjct: 734  AVKEDLPVGANILKIKAYDADSGFNGKVLFTIS-DGNTDSCFNIDMETGQLKVLMPMDRE 792

Query: 100  REDEIEAIISISDGLNLVAEK---VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFK 156
              D     I+I D  N        + I V DAND +P FIQ+ Y   + E    G+ I +
Sbjct: 793  HTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQ 852

Query: 157  VHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            V A D+D GS G VTY +      FA++  +G++ +     LD E    + + + A+D  
Sbjct: 853  VEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYV--ADQLDRESKANYSLKIEARD-- 908

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
             +      +FS  T + V ++DV D +P F+ + Y   V ED   G+ +  +   D D G
Sbjct: 909  -KAESGQQLFSVVT-LKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLG 966

Query: 277  KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQAT 336
               ++ YSLVN  +G FEI++ SGAI +++     +++ Y L V+  +    G P + ++
Sbjct: 967  LGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KGRPVSLSS 1023

Query: 337  VP-VTIRIVDLNN--HPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
            V  V + +VD+N   H P F     P      S+ E+   G  +  L++T  D D G + 
Sbjct: 1024 VSFVEVEVVDVNENLHTPYF-----PDFAVVGSVKENSRIGTSV--LQVTARDEDSGRDG 1076

Query: 394  KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS 453
            +    +    G+ R    ++ +E+ V   +  +  +D E        + A +      + 
Sbjct: 1077 EIQYSIRDGSGLGRF---SIDDESGV---ITAADILDRETMGSYWLTVYATDRGVVPLY- 1129

Query: 454  STADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TY 512
            ST +V I++ D NDN P      Y   + EN+P   SV+ + A DPD+    ++ Y  T 
Sbjct: 1130 STIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITS 1189

Query: 513  GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVN 570
            G   + F I+  TGLI T     LD E  A +   V   D     K S   V + +LD N
Sbjct: 1190 GNPQNFFAINIKTGLITTTS-RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDEN 1248

Query: 571  DHPPQFGKSV------QKKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDIN 623
            D+ PQF + V      ++     G P+ +  A D D E PN  + YSI        F I+
Sbjct: 1249 DNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRD-EGPNAEISYSIVDGNDDGKFFID 1307

Query: 624  SHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLS 683
              TG +          +    T G   +  L ++A D G P  S+TA L I+       S
Sbjct: 1308 PKTGMV---------SSRKQFTAGSYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPS 1356

Query: 684  RSPMA------AFLIQTKDNPMKAVGVLA 706
              P+        F +   D   + VGV++
Sbjct: 1357 PIPLTFDEPFYNFTVMESDRVTEIVGVVS 1385



 Score =  185 bits (470), Expect = 1e-46
 Identities = 165/605 (27%), Positives = 270/605 (44%), Gaps = 70/605 (11%)

Query: 62   PEGDPISYHI---SFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
            P   P+ + I   +FD    S F  +   G I + + LD E+       + ++DG N+  
Sbjct: 1388 PANTPLWFDIVGGNFD----SAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAV 1443

Query: 119  EKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH 178
             +V I V D ND  P F Q  Y   + ED+   + I ++ A DRD     S T     +H
Sbjct: 1444 TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYT-----VH 1498

Query: 179  S--------PFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATT 230
            S         F +D  +GV  L     LD+E    H + ++ +D                
Sbjct: 1499 SSIDSISMRKFRIDPSTGV--LYTAERLDHEAQDKHILNIMVRDQEFPYR------RNLA 1550

Query: 231  TVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND 290
             V VNVED  D +P F    Y   V+E    GS VL+V A+D D+G+   ++Y++  GN 
Sbjct: 1551 RVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610

Query: 291  G-AFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNH 349
            G  F+I    G I+I + P       + L ++VT+    GSP   AT  V I +   +N 
Sbjct: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQ---GSPPMSATAIVRISVTMSDNS 1667

Query: 350  PPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVV 409
             P F  +      ++  +NE+     +  G  + +  +   +   + ++     GIF + 
Sbjct: 1668 HPKFIHKD-----YQAEVNEN-----VDIGTSVILISAISQSTLIYEVKDGDINGIFTIN 1717

Query: 410  PQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNV 469
            P +         ++    A+D+E++   +++L+ ++       +S A V IQ++D NDN 
Sbjct: 1718 PYSG--------VITTQKALDYERTS--SYQLI-IQATNMAGMASNATVNIQIVDENDNA 1766

Query: 470  PKFDSLYYVARIPENAPGGS-------SVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLI 521
            P F    Y   + E AP  S       S + + A D D+     + Y     T    F +
Sbjct: 1767 PVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTV 1826

Query: 522  HPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY----SVAEVFITLLDVNDHPPQFG 577
              STG I T   A+LD E  A ++F+V   D         S  EV I + DVND+PP F 
Sbjct: 1827 DSSTGAIRT--IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFT 1884

Query: 578  KSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD---INSHTGEIWLKNS 634
            ++V +  ++L T V +E +   A +P++ V   +T++      D   I+S++G + +KN+
Sbjct: 1885 QAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNN 1944

Query: 635  IRSLD 639
              S D
Sbjct: 1945 NLSKD 1949



 Score =  176 bits (447), Expect = 6e-44
 Identities = 186/741 (25%), Positives = 310/741 (41%), Gaps = 105/741 (14%)

Query: 32   VGSTNGNMALFS-------LPEDTPVGSHVYTLNGTD-PEGDPISYHISFDPSTRSVFSV 83
            +G+ N N  LF        +  D PVG H+  ++  D  E + + Y I    +    F +
Sbjct: 568  IGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKI-ISGNELGFFYL 626

Query: 84   DPTFGNITLVEELDRE--REDEIEAIISISDGLNL------------------------- 116
            +P  G + L + L     +       I+ +DG NL                         
Sbjct: 627  NPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRET 686

Query: 117  -----VAEKVVILVT---------------DANDEAPRFIQE-PYVALVPEDIPAGSIIF 155
                 +AEK++I                    N + P F +  P    V ED+P G+ I 
Sbjct: 687  RVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANIL 746

Query: 156  KVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
            K+ A D D+G  G V + +   N  S F +D  +G L++     +D E +  + + +   
Sbjct: 747  KIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVL--MPMDREHTDLYLLNITIY 804

Query: 214  DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG 273
            D G          S+   +T+NVED  D +PVF+   Y   + E +  G+E+++V A D 
Sbjct: 805  DLGNPQK------SSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDK 858

Query: 274  DRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 333
            D G    + YS++      F IN ++G + +     +  +  Y L ++  + + +G    
Sbjct: 859  DLGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLF 917

Query: 334  QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
             + V + + + D+N+  P F   S     + + + E  P G ++  L+   +D D G   
Sbjct: 918  -SVVTLKVFLDDVNDCSPAFIPSS-----YSVKVLEDLPVGTVIAWLE--THDPDLGLGG 969

Query: 394  KFNLQLVGP-RGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKF 452
            +    LV    G F +         + +  +  S  +D+EK +     + A +   P   
Sbjct: 970  QVRYSLVNDYNGRFEI--------DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSL 1021

Query: 453  SSTADVVIQLLDTNDNV--PKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS 510
            SS + V ++++D N+N+  P F     V  + EN+  G+SV+ VTA D D+G  GE++YS
Sbjct: 1022 SSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYS 1081

Query: 511  TY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLL 567
               G+G   F I   +G+I       LD E    Y   V A D  +   YS  EV+I + 
Sbjct: 1082 IRDGSGLGRFSIDDESGVITAAD--ILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVE 1139

Query: 568  DVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEP----NNLVDYSITHAEPANVFDIN 623
            DVND+ P   + +    ++  +P  +  I   AE+P    N  + Y IT   P N F IN
Sbjct: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAIN 1199

Query: 624  SHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRG-SPSFSTTALLKIDITDAETL 682
              TG I    + R LD        +     LEV   D G SP  ST  ++   + + +  
Sbjct: 1200 IKTGLI--TTTSRKLDR------EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNK 1251

Query: 683  SRSPMAAFLIQTKDNPMKAVG 703
             + P   + I+  +   K  G
Sbjct: 1252 PQFPEKVYQIKLPERDRKKRG 1272



 Score =  172 bits (437), Expect = 9e-43
 Identities = 171/608 (28%), Positives = 276/608 (45%), Gaps = 62/608 (10%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISY-HISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            LPED P    +  ++  D +     Y   S   S  S F +DP  G +  +  LDRER  
Sbjct: 3038 LPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIP 3097

Query: 103  EIEAIISISDGLNLVAEKVV-ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
                +   +DG     +  + +++ D ND  P F  + Y   V E+    +++ +V AVD
Sbjct: 3098 VYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVD 3157

Query: 162  RDTGSGGSVTYFL-QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLH 220
             D G    V Y L  +    F++D  SG++ L+    LD E+  ++ I+V A D      
Sbjct: 3158 PDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQ--PLDREQQSSYNISVRATD-----Q 3210

Query: 221  GADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNR 280
                  S+ TTVT+ V D+ D  PVF    Y   V EDT PG++VL V A   D G    
Sbjct: 3211 SPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAE 3270

Query: 281  ILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPV 339
            I Y + +GN+ G F+IN  +G IS+++    L  E+ +    V E    G+PA  A   V
Sbjct: 3271 ITYLIRSGNEQGKFKINPKTGGISVSEV---LDYELCKRFYLVVEAKDGGTPALSAVATV 3327

Query: 340  TIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQL 399
             I + D+N++PP F      Q+ +   ++E    G+ +  + +   D D   N + +  +
Sbjct: 3328 NINLTDVNDNPPKF-----SQDVYSAVISEDALVGDSV--ILLIAEDVDSQPNGQIHFSI 3380

Query: 400  V-GPR-GIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTAD 457
            V G R   F V P        V  +V+    +D E+    +  + AV+   P   SSTA 
Sbjct: 3381 VNGDRDNEFTVDP--------VLGLVKVKKKLDRERVSGYSLLVQAVDSGIPA-MSSTAT 3431

Query: 458  VVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDT---GPWGEVKYSTYGT 514
            V I + D NDN P F    Y A I EN P G+S++ +   D D+   GP       + G 
Sbjct: 3432 VNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILS-GN 3490

Query: 515  GADLFLIHPSTGL---IYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITL--LDV 569
              + F++ P   L   +  Q   SL+      Y   V+A+D      V+  +I +  ++ 
Sbjct: 3491 EEEEFVLDPHGILRSAVVFQHTESLE------YVLCVQAKDSGKPQQVSHTYIRVRVIEE 3544

Query: 570  NDHPPQFGKSVQKKTMVL--------GTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
            + H P    ++  +  ++        G   KI A D+D  +   ++ +++  +E  ++F 
Sbjct: 3545 STHKPT---AIPLEIFIVTMEDDFPGGVIGKIHATDQDMYD---VLTFALK-SEQKSLFK 3597

Query: 622  INSHTGEI 629
            +NSH G+I
Sbjct: 3598 VNSHDGKI 3605



 Score =  170 bits (431), Expect = 5e-42
 Identities = 186/679 (27%), Positives = 283/679 (41%), Gaps = 73/679 (10%)

Query: 32   VGSTNGNMALFS-------LPEDTPVGSHVYTLNGTDPEG---DPISYHISFDPSTRSVF 81
            +   N N  +F+       + E  P G  V  +  +D +    D + Y I    + R+ F
Sbjct: 2384 ISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSI-LSGNDRTSF 2442

Query: 82   SVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYV 141
             +D   G ITL     +  E      +S+SDGL     +V I V  AN  +P F Q  YV
Sbjct: 2443 LMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYV 2502

Query: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVL---RLQAGA 196
            A V E++ AG+ +  V A D D G+ G ++Y + N      F +D +  V+   RL    
Sbjct: 2503 AEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDREN 2562

Query: 197  TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
             L+ + S    I V A DGGGR        +   TV V V D  D AP F+   Y   V 
Sbjct: 2563 PLEGDVS----IFVRALDGGGR--------TTFCTVRVIVVDENDNAPQFMTVEYRASVR 2610

Query: 257  EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETSGAISITQSPAQLQ 312
             D   G  V +V A+D D G  +RI YSL +    +     EI+  +G +    +  QL+
Sbjct: 2611 ADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLK 2670

Query: 313  REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPP 372
              V    V+  +    G P   + +PV I ++     PP  +  S  Q+++  ++ E   
Sbjct: 2671 NTVLSFFVKAVD---GGIPVKHSLIPVYIHVL-----PPETFLPSFTQSQYSFTIAEDTA 2722

Query: 373  QGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 432
             G  +  L+I  + +   +            GIF +         Q T  ++    +D E
Sbjct: 2723 IGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVI--------EQETGTIKLDKRLDRE 2774

Query: 433  KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
             S    FK+ A           T DV I++LD NDN P F++  Y   I E  P G+ + 
Sbjct: 2775 TSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLT 2834

Query: 493  AVTAVDPDTGPWGEVKYSTYGTG-----ADLFLIHPSTGLIYTQPWASLDAEATARYNFY 547
             V A+D D G  G+V YS +         + F I  +TG I T     LD E    + F 
Sbjct: 2835 QVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST--LKDLDHETDPTFTFS 2892

Query: 548  VKAEDMEGKYSV---AEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDED 599
            V A D+   +S+   A V + + D+ND+ P F + V +  +    P       +   D D
Sbjct: 2893 VVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRD 2952

Query: 600  AEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAK 659
              + N  V Y IT   P   F +     E W     R LD           ++ L + A 
Sbjct: 2953 TSDVNRQVSYHITGGNPRGRFALGLVQSE-WKVYVKRPLDR------EEQDIYFLNITAT 3005

Query: 660  DRGSPSFSTTALLKIDITD 678
            D     F T A++++ ++D
Sbjct: 3006 D---GLFVTQAMVEVSVSD 3021



 Score =  147 bits (371), Expect = 4e-35
 Identities = 167/656 (25%), Positives = 288/656 (43%), Gaps = 69/656 (10%)

Query: 47   DTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDE 103
            D   G+ +Y +   D +  P   ++Y +  D      F ++P  GN+ L E  + +  + 
Sbjct: 2096 DAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH---FEINPNSGNVILKEAFNSDLSN- 2151

Query: 104  IE---AIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV 160
            IE    I++   G   ++  V + +T  N   P F +  Y A V EDI   + I  ++A 
Sbjct: 2152 IEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211

Query: 161  DRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGR 218
              +   G  + Y +   +    F +D  +GVL++ +   LDYE +  + +T+ A D    
Sbjct: 2212 SPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVS--PLDYEVTSAYKLTIRASDA--- 2263

Query: 219  LHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKP 278
            L GA     A  TV + V DV D  P+F    Y   + E +L G+ VL+VV++D D    
Sbjct: 2264 LTGA----RAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENN 2319

Query: 279  NRILYSLVNGNDGA---FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQA 335
              + Y +V     +   F I+ +SG I   +    L  E+ +          +G P+  +
Sbjct: 2320 KMVHYQIVQDTYNSTDYFHIDSSSGLILTAR---MLDHELVQHCTLKVRSIDSGFPSLSS 2376

Query: 336  TVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKF 395
             V V I I D+N++PP F      Q  +E  ++E  P+G  +  ++ +  DS      ++
Sbjct: 2377 EVLVHIYISDVNDNPPVFN-----QLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEY 2431

Query: 396  NLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSST 455
            ++     R  F      +++     I + N       K ++     L V V+    F+ST
Sbjct: 2432 SILSGNDRTSF------LMDSKSGVITLSNH-----RKQRMEPLYSLNVSVSDG-LFTST 2479

Query: 456  ADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTG 515
            A V I++L  N   P F    YVA + EN   G+ V+ V A D D G +G++ Y+     
Sbjct: 2480 AQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDF 2539

Query: 516  A-DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPP 574
            A D FLI  S G + T      +       + +V+A D  G+ +   V + ++D ND+ P
Sbjct: 2540 AKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAP 2598

Query: 575  QFGKSVQKKTMVLG------TPVKIEAIDEDAEEPNNLVDYSI---THAEPANVFDINSH 625
            QF  +V+ +  V           +++AID D +  N+ + YS+        A++ +I+  
Sbjct: 2599 QF-MTVEYRASVRADVGRGHLVTQVQAIDPD-DGANSRITYSLYSEASVSVADLLEIDPD 2656

Query: 626  TGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAET 681
             G +  K +   L         ++ + S  V+A D G P   +   + I +   ET
Sbjct: 2657 NGWMVTKGNFNQL---------KNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPET 2703



 Score =  145 bits (365), Expect = 2e-34
 Identities = 165/670 (24%), Positives = 292/670 (43%), Gaps = 68/670 (10%)

Query: 22   NFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVF 81
            +F   F+   +   N N+   ++     VG+ +          +P+ Y I  +P  +  F
Sbjct: 1981 HFTQSFYSTSISENNTNITKVAIVN--AVGNRL---------NEPLKYSI-LNPGNK--F 2026

Query: 82   SVDPTFGNI-TLVEELDREREDEIEAIISIS---DGLNLVAEKVVILVTDANDEAPRFIQ 137
             +  T G I T     DRE ++  E ++  S   D L +    V + + D ND +P F+ 
Sbjct: 2027 KIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVG 2086

Query: 138  EPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGAT 197
             PY A V  D   G++I++V A+D+D G  G VTY LQ+ +  F ++ +SG + L+    
Sbjct: 2087 LPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFN 2146

Query: 198  LDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYE 257
             D      + +T++AKDGG          S +T+V + +  V    PVF    Y   V E
Sbjct: 2147 SDLSNIE-YGVTILAKDGGKP--------SLSTSVELPITIVNKAMPVFDKPFYTASVNE 2197

Query: 258  DTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVY 316
            D    + +L + A   +      I+Y +++G+    F I+  +G + +           Y
Sbjct: 2198 DIRMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254

Query: 317  ELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEI 376
            +L ++ ++        A+A V V + + D+N++PP F      Q  +  +++E    G  
Sbjct: 2255 KLTIRASD----ALTGARAEVTVDLLVNDVNDNPPIF-----DQPTYNTTLSEASLIGTP 2305

Query: 377  LRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKV 436
            +  L++   D+D   N   + Q+V  +  +       ++ +   I+   +  +D E  + 
Sbjct: 2306 V--LQVVSIDADSENNKMVHYQIV--QDTYNSTDYFHIDSSSGLIL--TARMLDHELVQH 2359

Query: 437  LTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTA 496
             T K+ +++   P   SS   V I + D NDN P F+ L Y + + E AP G  V  V A
Sbjct: 2360 CTLKVRSIDSGFP-SLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418

Query: 497  VDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEG 555
             D D+  +  ++YS   G     FL+   +G+I          E     N  V     +G
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVS----DG 2474

Query: 556  KY-SVAEVFITLLDVNDHPPQFGKSVQ----KKTMVLGTPV-KIEAIDEDAEEPNNLVDY 609
             + S A+V I +L  N + P F +S      ++ +  GT V  + A D D       + Y
Sbjct: 2475 LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQ-ISY 2533

Query: 610  SITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS-PSFST 668
            +I +    + F I+S+ G++     +   + L           S+ V+A D G   +F T
Sbjct: 2534 AIINDFAKDRFLIDSN-GQVITTERLDRENPLEGDV-------SIFVRALDGGGRTTFCT 2585

Query: 669  TALLKIDITD 678
              ++ +D  D
Sbjct: 2586 VRVIVVDEND 2595



 Score =  142 bits (358), Expect = 1e-33
 Identities = 174/662 (26%), Positives = 286/662 (43%), Gaps = 77/662 (11%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            S+ E++ +G+ V  +   D +      I Y I  D S    FS+D   G IT  + LDRE
Sbjct: 1051 SVKENSRIGTSVLQVTARDEDSGRDGEIQYSIR-DGSGLGRFSIDDESGVITAADILDRE 1109

Query: 100  REDEIEAIISISDG--LNLVAE-KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFK 156
                    +  +D   + L +  +V I V D ND AP   +  Y  +V E+ P    + +
Sbjct: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQ 1169

Query: 157  VHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 214
            + A D D+ S   +TY +   N  + FA++  +G++   +   LD E+   H++ V   D
Sbjct: 1170 IQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS-RKLDREQQAEHFLEVTVTD 1228

Query: 215  GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-------GSEVLK 267
            GG           +T  V V V D  D  P F        VY+  LP       G  + +
Sbjct: 1229 GGPSPK------QSTIWVVVQVLDENDNKPQFPEK-----VYQIKLPERDRKKRGEPIYR 1277

Query: 268  VVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMS 326
              A D D G    I YS+V+GND G F I+  +G +S   S  Q     Y+  +   +  
Sbjct: 1278 AFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVS---SRKQFTAGSYD--ILTIKAV 1332

Query: 327  PAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
              G P   +T  + I  +     PP+    +  +  +  ++ E     EI+  + +    
Sbjct: 1333 DNGRPQKSSTARLHIEWI--KKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSV---- 1386

Query: 387  SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEV 446
              Q AN      +VG  G F            + I    +  +D E+  +     ++VEV
Sbjct: 1387 --QPANTPLWFDIVG--GNFDSAFDAEKGVGTIVI----AKPLDAEQRSIYN---MSVEV 1435

Query: 447  NTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
                  + T  V I++LD NDN P+F    Y   I E+    + ++ + A D D     +
Sbjct: 1436 TDGTNVAVT-QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--K 1492

Query: 507  VKYSTYGTGADL----FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY--SVA 560
            + Y+ + +   +    F I PSTG++YT     LD EA  ++   +   D E  Y  ++A
Sbjct: 1493 LSYTVHSSIDSISMRKFRIDPSTGVLYTAE--RLDHEAQDKHILNIMVRDQEFPYRRNLA 1550

Query: 561  EVFITLLDVNDHPPQFGKSVQKKTM----VLGTPV-KIEAIDEDAEEPNNLVDYSITHAE 615
             V + + D NDH P F   + + ++     LG+ V ++ A+D+D  E   L+ Y+I    
Sbjct: 1551 RVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELI-YTIEAGN 1609

Query: 616  PANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKID 675
              N+F I    G I +    +  D     T G+   + L ++  D+GSP  S TA+++I 
Sbjct: 1610 TGNMFKIEPVLGIITI---CKEPDMT---TMGQ---FVLSIKVTDQGSPPMSATAIVRIS 1660

Query: 676  IT 677
            +T
Sbjct: 1661 VT 1662



 Score =  126 bits (316), Expect = 1e-28
 Identities = 150/556 (26%), Positives = 241/556 (43%), Gaps = 49/556 (8%)

Query: 96  LDREREDEIEAIISIS-DGLNLVA-EKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSI 153
           L+RE +D    I+  S  G +L A  KV I V D ND  P F    Y   + E  P  + 
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176

Query: 154 IFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
           + +V A D D GS G   Y+ +N    F+V   SGV+ L     L+Y+    + + ++A 
Sbjct: 177 VAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISL--SGRLNYDEKNRYDLEILAV 234

Query: 214 DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG 273
           D G +L+G + V S+T  + V++E + + AP      +  +  E     + V      DG
Sbjct: 235 DRGMKLYGNNGV-SSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDG 293

Query: 274 DRGKPNRILYSLVNGN--DGAFEINETSGAISI-TQSPAQLQREVYELHVQVT-EMSPAG 329
             G+   +  S+V G+  D  F   E         +   Q+  E +     +T +    G
Sbjct: 294 ANGEIESV--SIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKG 351

Query: 330 SP-AAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSD 388
           SP    A   V I     +  P  F  E      +++S++E  P G ++  +K+    S 
Sbjct: 352 SPQKCSALKAVYIGNPTRDTVPIRFEKEV-----YDVSISEFSPPGVVVAIVKL----SP 402

Query: 389 QGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNT 448
           +  + ++ L        F++ P++ L        +  +  ++  K +V   ++      T
Sbjct: 403 EPIDVEYKLSPGEDAVYFKINPRSGL--------IVTARPLNTVKKEVYKLEV------T 448

Query: 449 PEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
            ++    A V I + D ND+ P+F    Y A + E+ P G+SV+ V+A D D G  G + 
Sbjct: 449 NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYIT 508

Query: 509 YSTYGTGADLFLIHPSTGLIYTQPWASLDAEATAR-YNFYVKAEDMEGKY---SVAEVFI 564
           YS        F+I+  TG+I T     LD E++   Y F V+A D    Y   S   V I
Sbjct: 509 YSIASLNLLPFVINQFTGVISTT--EELDFESSPEIYRFIVRASDWGSPYRHESEVNVTI 566

Query: 565 TLLDVNDHPPQFGKSVQKKTMVLGTPV-----KIEAIDEDAEEPNNLVDYSITHAEPANV 619
            + +VND+ P F K   +  +    PV      + AID D  E   LV Y I        
Sbjct: 567 RIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELE---LVKYKIISGNELGF 623

Query: 620 FDINSHTGEIWLKNSI 635
           F +N  +G + LK S+
Sbjct: 624 FYLNPDSGVLQLKKSL 639



 Score =  115 bits (287), Expect = 2e-25
 Identities = 160/702 (22%), Positives = 282/702 (40%), Gaps = 108/702 (15%)

Query: 43  SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
           ++ E TP+ + V  +  TD +         +  +   +FSV PT G I+L   L+ + ++
Sbjct: 166 TIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKN 225

Query: 103 EIE-AIISISDGLNLVAE-------KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154
             +  I+++  G+ L          K+ + +   N+ AP      +V    E  P  +++
Sbjct: 226 RYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVV 285

Query: 155 FKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVL---RLQAGATLDYERSRTHY-ITV 210
                 D   G   SV+    +    F + +    L   +++    +D+E     Y +T+
Sbjct: 286 TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345

Query: 211 VAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVA 270
            AKD      G+    SA   V +     +D  P+      Y     +  P   V+ +V 
Sbjct: 346 QAKD-----KGSPQKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVK 399

Query: 271 MDGDRGKPNRILYSLVNGNDGA-FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
           +  +   P  + Y L  G D   F+IN  SG I   +    +++EVY+L V   E    G
Sbjct: 400 LSPE---PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE----G 452

Query: 330 SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
              AQ    VTI I D N+H P F      Q  ++  +NE  P G  +  L ++ +D D+
Sbjct: 453 DLKAQ----VTISIEDANDHTPEF-----QQPLYDAYVNESVPVGTSV--LTVSASDKDK 501

Query: 390 GANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKS-KVLTFKLLAVEVNT 448
           G N      +        ++P  V+N  Q T ++  +  +DFE S ++  F + A +  +
Sbjct: 502 GENGYITYSIAS----LNLLP-FVIN--QFTGVISTTEELDFESSPEIYRFIVRASDWGS 554

Query: 449 PEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
           P +  S  +V I++ + NDN P F+ +     I  + P G  + AV+A+D D      VK
Sbjct: 555 PYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDID--ELELVK 612

Query: 509 YSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDME------------- 554
           Y    G     F ++P +G++  +   +        +   + A D E             
Sbjct: 613 YKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVL 672

Query: 555 -------------------------------GKYSVAEVFITLLDVNDHPPQFGKS---- 579
                                          GK ++ + F+    +N   P F KS    
Sbjct: 673 HGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSD 732

Query: 580 --VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRS 637
             V++   V    +KI+A D D+   N  V ++I+     + F+I+  TG++     +  
Sbjct: 733 VAVKEDLPVGANILKIKAYDADSGF-NGKVLFTISDGNTDSCFNIDMETGQL---KVLMP 788

Query: 638 LDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDA 679
           +D  H        L+ L +   D G+P  S+  LL I++ DA
Sbjct: 789 MDREHT------DLYLLNITIYDLGNPQKSSWRLLTINVEDA 824



 Score =  100 bits (248), Expect = 8e-21
 Identities = 128/463 (27%), Positives = 206/463 (44%), Gaps = 53/463 (11%)

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
           G + G D+   A T V + V D+ D+ P+F  T Y   + E T   + V +V A D D G
Sbjct: 131 GSVRGEDL--EAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIG 188

Query: 277 KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTE--MSPAGSPAAQ 334
                 Y   N  D  F ++ TSG IS++      ++  Y+L +   +  M   G+    
Sbjct: 189 SNGEFYYYFKNKVD-LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVS 247

Query: 335 ATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK 394
           +T  + + I  +N H PT +           S+ + P          +TV+D D GAN +
Sbjct: 248 STAKLYVHIERINEHAPTIH----VVTHVPFSLEKEPTYA------VVTVDDLDDGANGE 297

Query: 395 F-NLQLVGPRGI---FRVVPQTVLNEAQVTIIVENSAAIDFEKSKV-LTFKLLAVEVNTP 449
             ++ +V    +   F       LNE +    ++    ID+E         L A +  +P
Sbjct: 298 IESVSIVAGDPLDQFFLAKEGKWLNEYK----IKERKQIDWESFPYGYNLTLQAKDKGSP 353

Query: 450 EKFSSTADVVIQLLDTNDNVP-KFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
           +K S+   V I    T D VP +F+   Y   I E +P G  VVA+  + P+     +V+
Sbjct: 354 QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPG-VVVAIVKLSPEP---IDVE 408

Query: 509 YS-TYGTGADLFLIHPSTGLIYT-QPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITL 566
           Y  + G  A  F I+P +GLI T +P  ++  E      + ++  + EG    A+V I++
Sbjct: 409 YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEV-----YKLEVTNKEGDLK-AQVTISI 462

Query: 567 LDVNDHPPQFGKSVQ----KKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
            D NDH P+F + +      +++ +GT V  + A D+D  E N  + YSI        F 
Sbjct: 463 EDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGE-NGYITYSIASLN-LLPFV 520

Query: 622 INSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSP 664
           IN  TG I   ++   LD     +P    ++   V+A D GSP
Sbjct: 521 INQFTGVI---STTEELD--FESSPE---IYRFIVRASDWGSP 555



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 56/248 (22%), Positives = 105/248 (42%), Gaps = 39/248 (15%)

Query: 32   VGSTNGNMALFS-------LPEDTPVGSHVYTLNGTDPE----GDPISYHISFDPSTRSV 80
            +   N N  +F+       + E+ PVG+ +  L  TD +    G P S+ I    +    
Sbjct: 3436 ISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI-LSGNEEEE 3494

Query: 81   FSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKV------VILVTDANDEAPR 134
            F +DP   +  L   +  +  + +E ++ +    +   ++V      V ++ ++  +   
Sbjct: 3495 FVLDP---HGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTA 3551

Query: 135  FIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN-LHSPFAVDRHSGVLRLQ 193
               E ++  + +D P G +I K+HA D+D      +T+ L++   S F V+ H G +   
Sbjct: 3552 IPLEIFIVTMEDDFPGG-VIGKIHATDQDMYD--VLTFALKSEQKSLFKVNSHDGKIIAL 3608

Query: 194  AGATLDYERSRTHYITVVAKDGGGR------LHGADVVFS-ATTTVTVNVEDVQDMAPVF 246
             G  LD   S  + + V   DG  +      +H   +V      TVT+  E+V      F
Sbjct: 3609 GG--LD---SGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVS--PEDF 3661

Query: 247  VGTPYYGY 254
            VG   +G+
Sbjct: 3662 VGLHMHGF 3669


>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
          Length = 2916

 Score =  223 bits (568), Expect = 6e-58
 Identities = 199/665 (29%), Positives = 314/665 (47%), Gaps = 69/665 (10%)

Query: 34   STNGNMALFSLPEDTPVGSHVYTLNGTDPEGD----PISYHI-SFDPSTRSVFSVDPTFG 88
            S    + + S+ E+ P+G+ VY  N  D +G      I Y+I S +P T   F + P+FG
Sbjct: 1054 SFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNP-FLIHPSFG 1112

Query: 89   NITLVEELDREREDEIEAIISISDGLNLVAEKVV------ILVTDANDEAPRFIQEPYVA 142
             +  V  LDRE    +   ++ SD    V ++ +      I++ D ND  P FI  P  A
Sbjct: 1113 TLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-A 1171

Query: 143  LVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDY 200
             V ED+  GS++  + A D D G  G VTY +   N +  F +D  SG+L       LDY
Sbjct: 1172 HVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTC--PLDY 1229

Query: 201  ERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTL 260
            E    H +TV+A D G          S++ T+TV V DV D APVF    Y   V E+  
Sbjct: 1230 EMKTQHILTVLALDDG------TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQN 1283

Query: 261  PGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELH 319
            PG  V +V A+D D G  +++ + ++ G     FEIN  +G +  T    +  +EV+ L 
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343

Query: 320  VQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRG 379
            V V +    G P+  +T  +   + D N+H P F   S      E+  N+ P   E++  
Sbjct: 1344 VLVRD---GGFPSLSSTTTILCTVEDENDHAPEFIVSSYD---IEVLENQEP---EVV-- 1392

Query: 380  LKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTF 439
              +  +D D G N      ++            +  E   T       A+D E+    T 
Sbjct: 1393 YTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTT------RALDREQISNFTL 1446

Query: 440  KLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDP 499
             +L  ++  P + SS   + +++LD ND+ P F +LYY + + E+A  G+ V+ ++AVD 
Sbjct: 1447 VILCSDLGDPPR-SSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDK 1505

Query: 500  DTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKY 557
            D G  G+ +Y      +  F I P +G + T    +LD EA +++ F   A D  ++G  
Sbjct: 1506 DEGLNGQTEYFLTDEASGAFTIDPMSGTLKTS--NTLDREARSQHTFSAVARDCSIQGSR 1563

Query: 558  S---VAEVFITLLDVNDHPP-----QFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDY 609
            S   + +V++T  DVND+ P      F   +  ++    T V + A D D   PN  V +
Sbjct: 1564 STTVIIKVYVT--DVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDL-GPNGTVVF 1620

Query: 610  SITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTT 669
            S   AE  ++F I+ +TGEI  + +  S        P    +W L+++  D+G P+ +TT
Sbjct: 1621 SF--AETQSMFSIDKYTGEIQFQQNPSS-----EYFP----IW-LQLKVTDQGIPARTTT 1668

Query: 670  ALLKI 674
             LL I
Sbjct: 1669 GLLVI 1673



 Score =  183 bits (465), Expect = 5e-46
 Identities = 176/648 (27%), Positives = 301/648 (46%), Gaps = 76/648 (11%)

Query: 74   DPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAP 133
            +P T+  F++D   G + LV+ LD E   E E +I ISD ++     +V+ V D ND  P
Sbjct: 1933 NPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPP 1990

Query: 134  RFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQ 193
             F Q+ Y   VPE IP G  +  + A D +  S  +++Y + +    F++D  +G +   
Sbjct: 1991 VFSQDFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKEFSIDPKNGTIFTI 2048

Query: 194  AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
            +   L    S T ++ V A DGG      +    A T V + +ED+ + AP F    Y  
Sbjct: 2049 SPVLLLDTISTTQFL-VEASDGG------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101

Query: 254  YVYEDTLPGSEVLKVVAMDGDRGKPNR-ILYSLVNGN-DGAFEIN----------ETSGA 301
             + ED L GS ++    +D D  + N  + YS+++GN    F +           +  G 
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161

Query: 302  ISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQN 361
            + +  S   L RE    H  V   S +G P   +T  ++I+++D+N++PP F   S    
Sbjct: 2162 LVLLHS---LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS---- 2214

Query: 362  RFELSMNEHPPQGEILRGLKITVNDSDQGANAK--FNLQLVGPRGIFRVVPQTVLNEAQV 419
             +   + E  P G  +    ++ ND D G++A+  +N+     +G F +   T      V
Sbjct: 2215 -YHTHVKESTPLGSHI--TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENT-----GV 2266

Query: 420  TIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVA 479
              +++    +D+EK    T  + A +    +K  S A V + +LD ND+ P+F    +  
Sbjct: 2267 LYLIK---PLDYEKMTKFTLTVQASDAE--KKHFSFAVVFVSVLDDNDHAPQFMFSSFSC 2321

Query: 480  RIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-------TYGTG--ADLFLIHPSTGLIYT 530
             +PEN P  S++ ++ A+D D GP+GE+ YS       T+G     DLFLI P TG I+ 
Sbjct: 2322 IVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHA 2381

Query: 531  QPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGK--------SVQK 582
            +    LD E   +Y   V+A+D     +   V++ +  +++  P F +           K
Sbjct: 2382 K--QILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNK 2439

Query: 583  KTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALH 642
               ++G   ++EA D DA   + ++ YS+  + P   F +N   G I+L   IR+L  + 
Sbjct: 2440 DRQLIG---RVEASDADA-GIDGVILYSLGTSSP--FFSVNKTNGNIYL---IRALPLIK 2490

Query: 643  NITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAF 690
            +     D   +LE++       S S  A   + +  + +   +P+A F
Sbjct: 2491 SQLNKED---TLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535



 Score =  171 bits (434), Expect = 2e-42
 Identities = 169/635 (26%), Positives = 290/635 (45%), Gaps = 63/635 (9%)

Query: 81   FSVDPTFGNITLVEELDREREDE-IEAIISISDGLNLVAEKVVIL---VTDANDEAPRFI 136
            F +D + G++ L +ELD E     +  +I+     NL     V L   V D ND +P F 
Sbjct: 997  FEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQ 1056

Query: 137  QEPYVALVPEDIPAGSIIFKVHAVDRDTGS--GGSVTYFLQNLH---SPFAVDRHSGVLR 191
             E  V  V E++P G++++  +A D D GS     + Y++++ +   +PF +  H     
Sbjct: 1057 DELIVISVEENVPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGTNPFLI--HPSFGT 1113

Query: 192  LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
            L   + LD E   T  +TV A D    +    +    + T  + + DV D  P F+  P 
Sbjct: 1114 LVTVSRLDRESIPTVILTVTASDQAVNVTDRRL---RSLTAQIVILDVNDHNPTFISFP- 1169

Query: 252  YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDG-AFEINETSGAISITQSPAQ 310
              +V ED   GS V  + A D D G+  ++ YS+++GN+   F ++E+SG ++ T     
Sbjct: 1170 NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT---CP 1226

Query: 311  LQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEH 370
            L  E+   H+        G+PA  ++  +T+ ++D+N+  P F      Q+ +E S+ E+
Sbjct: 1227 LDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVF-----KQHLYEASVKEN 1281

Query: 371  PPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAID 430
               GE +   ++   D D G N+K   +++ P   F +     +N     ++   +  +D
Sbjct: 1282 QNPGEFV--TRVEALDRDSGVNSKLQFEIM-PGASFELFE---INSDTGEVV--TTTILD 1333

Query: 431  FEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSS 490
             E  +V T ++L  +   P   SST  ++  + D ND+ P+F    Y   + EN      
Sbjct: 1334 REIQEVFTLRVLVRDGGFP-SLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQE-PEV 1391

Query: 491  VVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVK 549
            V  V A D D G    V+Y    G   + F I+  +G + T    +LD E  + +   + 
Sbjct: 1392 VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTT--RALDREQISNFTLVIL 1449

Query: 550  AEDM--EGKYSVAEVFITLLDVNDHPPQF-----GKSVQKKTMVLGTPVKIEAIDEDAEE 602
              D+    + SV  + + +LD NDH P F       SV++   V    + + A+D+D E 
Sbjct: 1450 CSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKD-EG 1508

Query: 603  PNNLVDYSITHAEPANVFDINSHTGEIWLKNSI-RSLDALHNITP-GRDCLWSLEVQAKD 660
             N   +Y +T  E +  F I+  +G +   N++ R   + H  +   RDC     +Q   
Sbjct: 1509 LNGQTEYFLTD-EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC----SIQG-- 1561

Query: 661  RGSPSFSTTALLKIDITDAE----TLSRSPMAAFL 691
                S STT ++K+ +TD       L ++P   FL
Sbjct: 1562 ----SRSTTVIIKVYVTDVNDNDPVLEQNPFDVFL 1592



 Score =  145 bits (366), Expect = 2e-34
 Identities = 169/675 (25%), Positives = 299/675 (44%), Gaps = 66/675 (9%)

Query: 46   EDTPVGSHVYTLNGTDPEG--DPISYHISFDPSTRSVFSVDPTFGNITLVEE--LDRERE 101
            E+   G+ + T+    P+   D + Y I F  +   V S+    G +T+ E   LD E  
Sbjct: 1695 ENCEAGTSIVTVKAFAPDSIQDSMKYSI-FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVR 1753

Query: 102  DEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
            +E++ I+      +    KV +L+ D ND +P F Q  Y A V E     + + +V A D
Sbjct: 1754 NEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATD 1813

Query: 162  RDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG-GR 218
             D+G  G + Y +   N    F +D  SGV+  +  A LDYE + ++ + V A D G  R
Sbjct: 1814 LDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK--AILDYELTSSYSLIVQATDKGMPR 1871

Query: 219  LHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKP 278
            L       S TT + V V D+ D AP F+ +     + ED+LPG  V  V   D D    
Sbjct: 1872 L-------SNTTVIKVQVTDINDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSA 1923

Query: 279  NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVP 338
                ++  +     F I++ +G + + ++    +   YEL +Q+++       A      
Sbjct: 1924 FIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGA------ 1977

Query: 339  VTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQ 398
            + +R++D+N++PP F      Q+ +++++ E  P G  +    +T++ +D  +N   + +
Sbjct: 1978 LVVRVLDVNDNPPVF-----SQDFYQVTVPESIPVGYSV----LTLSATDLESNENISYR 2028

Query: 399  LVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADV 458
            ++     F + P+   N    TI    S  +  +      F + A +   P+  + T  V
Sbjct: 2029 ILSSSKEFSIDPK---NGTIFTI----SPVLLLDTISTTQFLVEASDGGNPDLRALTL-V 2080

Query: 459  VIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD-TGPWGEVKYSTY-GTGA 516
             I + D N+  P+F    Y   + E+A  GS++V  + +D D T     V+YS   G   
Sbjct: 2081 EIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQ 2140

Query: 517  DLFLI--------HPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITL 566
            + F +        +P   + Y     SLD EA+A +   + A D       S A + I +
Sbjct: 2141 NNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQV 2200

Query: 567  LDVNDHPPQFGK----SVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
            LDVND+PP F      +  K++  LG+ + + + ++     +  + Y+I        F +
Sbjct: 2201 LDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYL 2260

Query: 623  NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETL 682
              +TG ++L   I+ LD    +T      ++L VQA D     FS   +    + D +  
Sbjct: 2261 EENTGVLYL---IKPLD-YEKMTK-----FTLTVQASDAEKKHFSFAVVFVSVLDDNDHA 2311

Query: 683  SRSPMAAFLIQTKDN 697
             +   ++F     +N
Sbjct: 2312 PQFMFSSFSCIVPEN 2326



 Score =  138 bits (348), Expect = 2e-32
 Identities = 153/611 (25%), Positives = 256/611 (41%), Gaps = 54/611 (8%)

Query: 80   VFSVDPTFGNITLVEELDREREDEIEAIISISDG-LNLVAEKVVILVT--DANDEAPRFI 136
            +F ++   G +     LDRE ++     + + DG    ++    IL T  D ND AP FI
Sbjct: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375

Query: 137  QEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQA 194
               Y   V E+     +++ V A D D G+  +V Y +   N    F ++  SG   L  
Sbjct: 1376 VSSYDIEVLEN-QEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG--ELST 1432

Query: 195  GATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGY 254
               LD E+     + ++  D G      D   S+   + V V D  D +P F    Y   
Sbjct: 1433 TRALDREQISNFTLVILCSDLG------DPPRSSVIHLQVRVLDANDHSPSFPTLYYQSS 1486

Query: 255  VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQRE 314
            V ED   G+ VL + A+D D G   +  Y L +   GAF I+  SG +  + +  +  R 
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARS 1546

Query: 315  VYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG 374
             +       + S  GS +   TV + + + D+N++ P        QN F++ ++   P  
Sbjct: 1547 QHTFSAVARDCSIQGSRST--TVIIKVYVTDVNDNDPVL-----EQNPFDVFLSPESPTN 1599

Query: 375  EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKS 434
            +    + +  +D D G N          + +F +   T   + Q     +N ++  F   
Sbjct: 1600 QTT--VIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQ-----QNPSSEYFP-- 1650

Query: 435  KVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAV 494
              +  +L   +   P +  +T  +++  ++  D    F    Y   + EN   G+S+V V
Sbjct: 1651 --IWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTV 1706

Query: 495  TAVDPDTGPWGEVKYSTYGTGAD--LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED 552
             A  PD+     +KYS +    D  L L   S  L   +P   LD E        V AE 
Sbjct: 1707 KAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEP-KFLDFEVRNEVQLIVLAES 1764

Query: 553  MEGKYSVAEVFITLLDVNDHPPQFGK-----SVQKKTMVLGTPVKIEAIDEDAEEPNNLV 607
              G  +  +V + + D ND+ P F +     SV +  +     +++ A D D+   N L+
Sbjct: 1765 -SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDS-GLNGLI 1822

Query: 608  DYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFS 667
            +YSI        F I++ +G I  K  +      + +T      +SL VQA D+G P  S
Sbjct: 1823 EYSILSGNQEEAFQIDALSGVITTKAILD-----YELTSS----YSLIVQATDKGMPRLS 1873

Query: 668  TTALLKIDITD 678
             T ++K+ +TD
Sbjct: 1874 NTTVIKVQVTD 1884



 Score =  121 bits (304), Expect = 2e-27
 Identities = 144/558 (25%), Positives = 227/558 (40%), Gaps = 68/558 (12%)

Query: 43   SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPSTRSVFSVDPTFGNI-TLVEELDRER 100
            ++PE  PVG  V TL+ TD E  + ISY I    S+   FS+DP  G I T+   L  + 
Sbjct: 2000 TVPESIPVGYSVLTLSATDLESNENISYRIL---SSSKEFSIDPKNGTIFTISPVLLLDT 2056

Query: 101  EDEIEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
                + ++  SDG N        V I + D N+ AP F  + Y   + ED   GS +   
Sbjct: 2057 ISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTF 2116

Query: 158  HAVDRD-TGSGGSVTYFL--QNLHSPFAVDR---HSGVLRLQAG-----ATLDYERSRTH 206
              +D D T     V Y +   N  + F V+    HS     Q G      +LD E S +H
Sbjct: 2117 SNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH 2176

Query: 207  YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL 266
             + ++A D G          S+T  +++ V DV D  P F    Y+ +V E T  GS + 
Sbjct: 2177 ELVILASDSG------CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHIT 2230

Query: 267  KVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEM 325
             V A D D G    I+Y++++GN+ G F + E +G + + +     +   + L VQ ++ 
Sbjct: 2231 VVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDA 2290

Query: 326  SPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVN 385
                   A     V + ++D N+H P F   S     F   + E+ P    +    I   
Sbjct: 2291 EKKHFSFA----VVFVSVLDDNDHAPQFMFSS-----FSCIVPENLPISSTI--CSINAL 2339

Query: 386  DSDQGANAKFNLQLVGP----------RGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSK 435
            D D G   +    +V P            +F + P T    A+  +  EN          
Sbjct: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG--------- 2390

Query: 436  VLTFKLLAVEVNTPEKFSSTADVV--IQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVA 493
                    + V   +K  +TA +V  + +   ++  P F    Y   +PE       +  
Sbjct: 2391 ----NKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGR 2446

Query: 494  VTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIY---TQPW--ASLDAEATARYNFYV 548
            V A D D G  G + YS  GT +  F ++ + G IY     P   + L+ E T       
Sbjct: 2447 VEASDADAGIDGVILYS-LGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA 2505

Query: 549  KAEDMEGKYSVAEVFITL 566
             +   + K++   VF+ +
Sbjct: 2506 HSPKSDSKFASCTVFVNV 2523



 Score =  121 bits (303), Expect = 3e-27
 Identities = 172/710 (24%), Positives = 274/710 (38%), Gaps = 108/710 (15%)

Query: 59   GTDPEGDPISYHISFDPSTRS-VFSVDPTFGNITLVEELDRERED----EIEAIISISDG 113
            G      P+ Y  S +PS  S +F + P  G I L  + D E        + A I     
Sbjct: 613  GPQRAASPLRY--SLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF 670

Query: 114  LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYF 173
            L  V+  V++ V D ND +P F+ +     V E      +I K+ A+D D+G  G + YF
Sbjct: 671  LQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYF 730

Query: 174  LQNLHSPFAVDRHSG------VLRLQAGAT------------------------------ 197
            L +    F ++ ++G      V+    GA                               
Sbjct: 731  LLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGE 790

Query: 198  ------LDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFV---- 247
                  LD E    H +TV+  D G          +AT  V V+V D+ D  P F     
Sbjct: 791  LINWVALDREHRGHHEMTVLVTDRGSPPR------NATMAVYVSVTDINDNRPFFPQCLP 844

Query: 248  GTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA--FEINETSGAISIT 305
            G   +  V E       V  V A D D G    + YS V+  D +  F+I+  +G I  T
Sbjct: 845  GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS-VSSEDSSDHFKIDANNGEIRTT 903

Query: 306  QSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFEL 365
               +   R  Y + V  T+    G P  Q    V I+++ L+            QN   L
Sbjct: 904  TILSYDYRPSYRMSVIATDQ---GVPPLQGQAVVNIQVIPLSKGRAIM-----SQNIRHL 955

Query: 366  SMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPR--GIFRVVPQTVLNEAQVTIIV 423
             + E+    +I+  +K + +   Q  N K +  +V     G F +   T      + +  
Sbjct: 956  IIPENLKPTKIMSLIKSS-DHLQQHYNGKLHFSIVADDKDGHFEIDSST----GDLFL-- 1008

Query: 424  ENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPE 483
              S  +D+E +    F+++  + +     SST  + I + D ND+ P F     V  + E
Sbjct: 1009 --SKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEE 1066

Query: 484  NAPGGSSVVAVTAVDPDTGPW--GEVKY--STYGTGADLFLIHPSTGLIYTQPWASLDAE 539
            N P G+ V    A D D G +    ++Y   ++  G + FLIHPS G + T   + LD E
Sbjct: 1067 NVPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTV--SRLDRE 1123

Query: 540  ATARYNFYVKAEDM-----EGKYSVAEVFITLLDVNDHPP---QFGKSVQKKTMVLGTPV 591
            +       V A D      + +       I +LDVNDH P    F  +  K+ + +G+ V
Sbjct: 1124 SIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSLV 1183

Query: 592  KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCL 651
                  +  E  N  V YSI        F ++  +G +     +       +I       
Sbjct: 1184 HHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHI------- 1236

Query: 652  WSLEVQAKDRGSPSFSTTALLKI---DITDAETLSRSPMAAFLIQTKDNP 698
              L V A D G+P+ S++  L +   D+ D   + +  +    ++   NP
Sbjct: 1237 --LTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284



 Score =  115 bits (289), Expect = 1e-25
 Identities = 167/670 (24%), Positives = 281/670 (41%), Gaps = 81/670 (12%)

Query: 45   PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTF-----GNITLVEELDRE 99
            P   P G+ +Y +   D          +F       F +   F     G +     LDRE
Sbjct: 742  PNTGPAGT-IYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800

Query: 100  REDEIEAIISISDGLNL---VAEKVVILVTDANDEAPRFIQ-----EPYVALVPEDIPAG 151
                 E  + ++D  +        V + VTD ND  P F Q     E +V ++ E  P  
Sbjct: 801  HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVL-EGQPVN 859

Query: 152  SIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQAGATLDYERSRTHYIT 209
             ++  V A D D G+   VTY + +  S   F +D ++G +R     + DY  S  + ++
Sbjct: 860  MLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPS--YRMS 917

Query: 210  VVAKDGG-GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268
            V+A D G   L G  V       V + V  +     +      +  + E+  P   +  +
Sbjct: 918  VIATDQGVPPLQGQAV-------VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLI 970

Query: 269  VAMDGDRGKPN-RILYSLV-NGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMS 326
             + D  +   N ++ +S+V +  DG FEI+ ++G + +++         Y   V  T+ S
Sbjct: 971  KSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHS 1030

Query: 327  PAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
               + +  +TV ++I + D N+H P+F  E        +S+ E+ P G ++       +D
Sbjct: 1031 K--NLSLSSTVFLSIDVEDQNDHSPSFQDE-----LIVISVEENVPIGTLVYVFNAKDDD 1083

Query: 387  SD----------QGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKV 436
                        +  N   N  L+ P     V    +  E+  T+I+  +A+        
Sbjct: 1084 GSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQ------ 1137

Query: 437  LTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTA 496
                  AV V      S TA +VI  LD ND+ P F S +  A + E+   GS V  +TA
Sbjct: 1138 ------AVNVTDRRLRSLTAQIVI--LDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITA 1188

Query: 497  VDPDTGPWGEVKYSTYGTGADL-FLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--M 553
             DPD G  G+V YS      ++ F++  S+GL+ T     LD E   ++   V A D   
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT--CPLDYEMKTQHILTVLALDDGT 1246

Query: 554  EGKYSVAEVFITLLDVNDHPPQFGK-----SVQKKTMVLGTPVKIEAIDEDAEEPNNLVD 608
                S   + +T+LDVND  P F +     SV++         ++EA+D D+   N+ + 
Sbjct: 1247 PALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDS-GVNSKLQ 1305

Query: 609  YSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFST 668
            + I       +F+INS TGE+ +  +I   +           +++L V  +D G PS S+
Sbjct: 1306 FEIMPGASFELFEINSDTGEV-VTTTILDREIQE--------VFTLRVLVRDGGFPSLSS 1356

Query: 669  TALLKIDITD 678
            T  +   + D
Sbjct: 1357 TTTILCTVED 1366



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 144/649 (22%), Positives = 255/649 (39%), Gaps = 97/649 (14%)

Query: 88  GNITLVEELDREREDEIEAIISISDGLNLVA---EKVVILVTDANDEAPRFIQEPYVALV 144
           G I L   L       +  ++S  DG  L A     V I +         F +  Y  LV
Sbjct: 327 GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386

Query: 145 PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGATLDYER 202
            ED+P  S I  V A +    S   + Y + +  L   F++    G +R +    LD+E 
Sbjct: 387 YEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRK--PLDHET 443

Query: 203 SRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPG 262
                +TV A+ G            ++T V + V DV D  P F+ T     + + T PG
Sbjct: 444 QPVVVLTVQAQLGSAPA-------CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPG 496

Query: 263 SEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQS-PAQLQREVYELHVQ 321
           + +    A D D G+   I YS+ +   G F I+   G + +  S  A  QRE     + 
Sbjct: 497 TALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRE-----LT 551

Query: 322 VTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEH-PPQGEILRGL 380
           +T  +       QA + V   +++   H P++  E      +++ ++E   P  ++L+  
Sbjct: 552 LTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE---HLVYQVEVSESLSPMTQMLQTQ 608

Query: 381 KITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFK 440
              +      +  +++L+      +F + P T          +      D+E ++   F+
Sbjct: 609 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGW--------IYLRRQFDYESTQTYNFR 660

Query: 441 LLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD 500
           + A         + +  V++++ D NDN P F       ++ E+      +  +TA+D D
Sbjct: 661 VFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMD 720

Query: 501 TGPWGEVKYSTYGTGADLFLIHPST---GLIYTQPWA----------------------- 534
           +G  G++ Y     G   F ++P+T   G IY   WA                       
Sbjct: 721 SGKNGQLLYFLLSDG-KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVL 779

Query: 535 ----------------SLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVNDHPPQF 576
                           +LD E    +   V   D     + +   V++++ D+ND+ P F
Sbjct: 780 KSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 839

Query: 577 -----GKSVQKKTMVLGTPVKI---EAIDEDAEEPNNL-VDYSITHAEPANVFDINSHTG 627
                GK +  K +  G PV +       +D +E NN  V YS++  + ++ F I+++ G
Sbjct: 840 PQCLPGKELHVKVLE-GQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNG 898

Query: 628 EIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDI 676
           EI    +I S D   +        + + V A D+G P     A++ I +
Sbjct: 899 EI-RTTTILSYDYRPS--------YRMSVIATDQGVPPLQGQAVVNIQV 938



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 55/162 (33%), Positives = 79/162 (48%), Gaps = 18/162 (11%)

Query: 156 KVHAVDRDTGSGGSVTYFLQN------LHSPFAVDRHSGVLRLQAGATLDYERSR---TH 206
           +V A D D+G  G + Y L +          F +D H G    Q   + D +R R   T+
Sbjct: 78  EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDG----QICVSQDIDRERDPATY 133

Query: 207 YITVVAKDGGGR--LHGADVV--FSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPG 262
            + V AKDG  +   H A V    SA   V V++EDV D  PVF  + Y   + ++T PG
Sbjct: 134 DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193

Query: 263 SEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAIS 303
           +E++ V+A D D G    + Y L+ GN    F I+ T+G  S
Sbjct: 194 TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS 235



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 39/116 (33%), Positives = 54/116 (46%), Gaps = 11/116 (9%)

Query: 453 SSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY 512
           S+ A V + L D NDN P F+   YV  I +    G+ ++ V A D D+G +G V Y   
Sbjct: 158 SAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 217

Query: 513 -GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLL 567
            G  + LF I  +TGL       S + E  +  NF    E M       E+F+ LL
Sbjct: 218 PGNVSSLFTIDSTTGLY------SPEVEILSAVNFSADKEVMNS----LEMFLPLL 263



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 39/125 (31%), Positives = 62/125 (49%), Gaps = 16/125 (12%)

Query: 81  FSVDPTFGNITLVEELDREREDEI-EAIISISDG-------LNLV-----AEKVV-ILVT 126
           F +DP  G I + +++DRER+    + ++   DG       L LV     A+  V + + 
Sbjct: 109 FRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLE 168

Query: 127 DANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVD 184
           D ND  P F    YV  + ++   G+ I  V A D+D+G  G+V Y L   N+ S F +D
Sbjct: 169 DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTID 228

Query: 185 RHSGV 189
             +G+
Sbjct: 229 STTGL 233



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 24/156 (15%)

Query: 494 VTAVDPDTGPWGEVKYSTYG-----TGADLFLIHPSTGLIYTQPWASLDAEA-TARYNFY 547
           VTA D D+G +G ++YS Y           F I P  G I       +D E   A Y+  
Sbjct: 79  VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS--QDIDRERDPATYDLL 136

Query: 548 VKAEDME------------GKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEA 595
           V+A+D +            G  + A V + L DVND+ P F  S    ++   T    E 
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196

Query: 596 IDEDAEEPNN----LVDYSITHAEPANVFDINSHTG 627
           I+  A + ++     V Y +     +++F I+S TG
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232


>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
          Length = 4588

 Score =  219 bits (558), Expect = 9e-57
 Identities = 202/717 (28%), Positives = 322/717 (44%), Gaps = 75/717 (10%)

Query: 27   FFDNGVGSTNGNMALF--SLP------EDTPVGSHVYTLNGTDPE---GDPISYHISFDP 75
            FFD+   S N ++  F  +LP      E+ PVGS V  +N TD +      + Y +S   
Sbjct: 703  FFDSH--SVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS-GG 759

Query: 76   STRSVFSVDPTFGNITLVEELDREREDEIEAIISISD-GLNLVA--EKVVILVTDANDEA 132
            +  S F +D   G + ++  LDRE  D+    I++ D G+   A    + ++V DAND  
Sbjct: 760  NEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNP 819

Query: 133  PRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRL 192
            P F+QE Y   V ED    S I +V A D+D G  G VTY +      F++D  +GV+ +
Sbjct: 820  PEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNI 879

Query: 193  QAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYY 252
                 LD E    H + + A+D   +      +FS T  V V++EDV D  P F+   Y 
Sbjct: 880  --ARPLDRELQHEHSLKIEARD---QAREEPQLFS-TVVVKVSLEDVNDNPPTFIPPNYR 933

Query: 253  GYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQ 312
              V ED   G+ ++ + A D D G+  ++ YSL++  +G F++++ SGA+ I Q     +
Sbjct: 934  VKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEK 993

Query: 313  REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTF--YGESGPQNRFELSMNEH 370
            ++VY L V+  +     S ++   V V +  V+ N HPP F  + E G       ++ E 
Sbjct: 994  KQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG-------TVKED 1046

Query: 371  PPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAID 430
             P G ++  +     D+ +    +++++     G+F++         + T ++E S  +D
Sbjct: 1047 APVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKI--------GEETGVIETSDRLD 1098

Query: 431  FEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSS 490
             E +      + A +       SS  ++ I++ D NDN P+     Y   I EN+P   S
Sbjct: 1099 RESTSHYWLTVFATDQGV-VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVS 1157

Query: 491  VVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVK 549
            VV + A DPD+    ++ Y  T G     F IHP TGLI T     LD E    +   V 
Sbjct: 1158 VVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS-RKLDREQQDEHILEVT 1216

Query: 550  AED--MEGKYSVAEVFITLLDVNDHPPQF------------GKSVQKKTMVLGTPVKIEA 595
              D     K ++A V + +LD ND+ PQF             K  +++         + A
Sbjct: 1217 VTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276

Query: 596  IDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLE 655
             D+D E PN  + YSI        F I   TG +  K    S    ++I         L 
Sbjct: 1277 TDKD-EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDI---------LS 1324

Query: 656  VQAKDRGSPSFSTTALLKIDITDAETLSRSPMA------AFLIQTKDNPMKAVGVLA 706
            ++A D G P  S+T  L I+       S  P++       F +   D     +GV++
Sbjct: 1325 IKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381



 Score =  204 bits (518), Expect = 4e-52
 Identities = 187/690 (27%), Positives = 303/690 (43%), Gaps = 66/690 (9%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDPISYHISF-----DPSTRSVFSVDPTFGNITLVEELD 97
            ++ ED P G  +  L+ TD + + I+  +++     DP  +           + + + LD
Sbjct: 2926 TVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLD 2985

Query: 98   REREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
            RE+ D     I+ +DG       V + V DAND +P   +  Y   +PED+  G +I ++
Sbjct: 2986 REKRDNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045

Query: 158  HAVDRDTGSGGSVTYFLQNLHSP-FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
             A D D  S   +TY L    +  F ++  +G   L+    LD E    +++ V A DGG
Sbjct: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTG--ELKTSTPLDREEQAVYHLLVRATDGG 3103

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
            GR   A +V +        +EDV D AP F   PY   V+E+T PG+ + +V A D D G
Sbjct: 3104 GRFCQASIVLT--------LEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAG 3155

Query: 277  KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP-AAQA 335
               +ILYSL++  DG F INE SG I + +   +  + VY L ++  +    G P    A
Sbjct: 3156 LNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQ---GLPRRLTA 3212

Query: 336  TVPVTIRIVDLNNHPPTF-YGESGPQNRFELSMNEHPPQGEILRG---LKITVNDSDQGA 391
            T  V + ++D+N++PP F Y E G       +++E     +IL G   L++     D  A
Sbjct: 3213 TGTVIVSVLDINDNPPVFEYREYG------ATVSE-----DILVGTEVLQVYAASRDIEA 3261

Query: 392  NAKFNLQLV--GPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
            NA+    ++     G F +  +T         I+EN   +D+E S      + A +  TP
Sbjct: 3262 NAEITYSIISGNEHGKFSIDSKT-----GAVFIIEN---LDYESSHEYYLTVEATDGGTP 3313

Query: 450  EKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKY 509
               S  A V + + D NDN P F    Y   I E+A    SV+ V A D D      + Y
Sbjct: 3314 -SLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHY 3372

Query: 510  STY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITL 566
            S   G     F I P  G +  +    LD E  + Y   V+A D     + +   V I +
Sbjct: 3373 SIIDGNQGSSFTIDPVRGEV--KVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDV 3430

Query: 567  LDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
             DVND+ P F +      +Q+   V  + +++   DED+        ++I        F+
Sbjct: 3431 SDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFE 3490

Query: 622  INSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAET 681
            +N   G +   ++I+  +  H         + L+V+  D G P  S+   + I + +   
Sbjct: 3491 VNPQ-GVLLTSSAIKRKEKDH---------YLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540

Query: 682  LSRSPMAAFLIQTKDNPMKAVGVLAGTMAT 711
               + +   +  T      + GV+    AT
Sbjct: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHAT 3570



 Score =  193 bits (490), Expect = 7e-49
 Identities = 186/676 (27%), Positives = 304/676 (44%), Gaps = 75/676 (11%)

Query: 42   FSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERE 101
            F++ E  PV +H+  +   +P G P+ + I+   +  S F VD   G I + + LD E++
Sbjct: 1365 FTVMESDPV-AHMIGVISVEPPGIPLWFDIT-GGNYDSHFDVDKGTGTIIVAKPLDAEQK 1422

Query: 102  DEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
                  +  +DG   +  +V I V D ND  P+F    Y  ++PED    + I ++ AVD
Sbjct: 1423 SNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVD 1482

Query: 162  RDTGSGGSVTYFLQNLHSP-----FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            +D  +   + Y LQ+   P     F +D  +G   L     LD+E    H +TV+ +D  
Sbjct: 1483 QDEKN--KLIYTLQSSRDPLSLKKFRLDPATG--SLYTSEKLDHEAVHQHTLTVMVRD-- 1536

Query: 217  GRLHGADVVFSAT-TTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDR 275
                  DV        + VNV D  D AP F  + Y G VYE    GS VL+V A+D D+
Sbjct: 1537 -----QDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDK 1591

Query: 276  GKPNRILYSLVNGNDG-AFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQ 334
            GK   +LYS+ +GN G +F I+   G+I   +   +  +  Y+L V+ T+    GSP   
Sbjct: 1592 GKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATD---KGSPPMS 1648

Query: 335  ATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK 394
                V I +   +N  P F         + + ++E      +  G  + +  +   ++  
Sbjct: 1649 EITSVRIFVTIADNASPKF-----TSKEYSVELSE-----TVSIGSFVGMVTAHSQSSVV 1698

Query: 395  FNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSS 454
            + ++       F + P +       TII +   A+DFE   + T   L ++       S+
Sbjct: 1699 YEIKDGNTGDAFDINPHS------GTIITQK--ALDFETLPIYT---LIIQGTNMAGLST 1747

Query: 455  TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSV-------VAVTAVDPDTGPWGEV 507
               V++ L D NDN P F    Y   I E+A   S V       + + A D D      +
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807

Query: 508  KYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAE----V 562
             Y          F I  STG I+T    SLD E T+ ++F V+  DM      AE    V
Sbjct: 1808 VYHIVEPSVHTYFAIDSSTGAIHTV--LSLDYEETSIFHFTVQVHDMGTPRLFAEYAANV 1865

Query: 563  FITLLDVNDHPPQFGKSVQKKTMVLGT-----PVKIEAIDEDAEEPNNLVDYSITHAEPA 617
             + ++D+ND PP F K + + +++L T      + + A D D+   + L+ YSIT     
Sbjct: 1866 TVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLI-YSITEGNIG 1924

Query: 618  NVFDINSHTGEIWLKNSIRSLDALHNIT----PGRDC-LWSLEVQAKDRGSPSFSTT--- 669
              F ++  TG + ++N+ + L + + +T     GR   L S+++  K+        T   
Sbjct: 1925 EKFSMDYKTGALTVQNTTQ-LRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDV 1983

Query: 670  --ALLKIDITDAETLS 683
              A++K + T+AETL+
Sbjct: 1984 YSAVVKENSTEAETLA 1999



 Score =  184 bits (467), Expect = 3e-46
 Identities = 191/677 (28%), Positives = 294/677 (43%), Gaps = 69/677 (10%)

Query: 32   VGSTNGNMALFS-------LPEDTPVGSHVYTLNGTDPEG---DPISYHISFDPSTRSVF 81
            V   N N  LF        + E  P G  V  +   D +    D + Y I    +    F
Sbjct: 2380 VTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSI-LSGNDHKHF 2438

Query: 82   SVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYV 141
             +D   G ITL        +      +S+SDG+   + +V + V   N  +P F+Q  Y 
Sbjct: 2439 VIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYE 2498

Query: 142  ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGATLD 199
              + E+ P  +++ +V   D D+G  G VTY + N      F ++    +  L+    LD
Sbjct: 2499 VELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LD 2555

Query: 200  YERSRTHYITV--VAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYE 257
             E      I+V  +AKD GG++        A  TV V + D  D AP F  T Y   +  
Sbjct: 2556 RETPAEKVISVRLMAKDAGGKV--------AFCTVNVILTDDNDNAPQFRATKYEVNIGS 2607

Query: 258  DTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA---FEINETSGAISITQSPAQLQRE 314
                G+ V+KV+A D D G    I Y++   ++      EIN+ SG I+  +S   L+ E
Sbjct: 2608 SAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENE 2667

Query: 315  VYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG 374
             +   V+  +    GSP+ ++ V V ++I+      P F   S P   F +S        
Sbjct: 2668 FFTFFVRAVDN---GSPSKESVVLVYVKILPPEMQLPKF---SEPFYTFTVSE------- 2714

Query: 375  EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKS 434
            ++  G +I +  ++      ++L + G           V++     + +E S  +D E +
Sbjct: 2715 DVPIGTEIDLIRAEHSGTVLYSL-VKGNTPESNRDESFVIDRQSGRLKLEKS--LDHETT 2771

Query: 435  KVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAV 494
            K   F +LA       +  ++ DV IQ+ D NDN P F+S  Y A I EN PGGS V+ +
Sbjct: 2772 KWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQI 2831

Query: 495  TAVDPDTGPWGEVKYSTYGTGA----DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKA 550
             A D D+G  G+V YS   + +    + F I+  TG I T     LD E    Y   V A
Sbjct: 2832 RASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITT--LKELDHEKRDNYQIKVVA 2889

Query: 551  EDMEGKY---SVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEE 602
             D   K    S A V +T+ DVND PP+F   + K T+    P       +   D D+EE
Sbjct: 2890 SDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEE 2949

Query: 603  PNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRG 662
             N  V Y IT  +P   F + +   E W     + LD        RD  + L + A D  
Sbjct: 2950 INRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLD-----REKRD-NYLLTITATD-- 3000

Query: 663  SPSFSTTALLKIDITDA 679
              +FS+ A++++ + DA
Sbjct: 3001 -GTFSSKAIVEVKVLDA 3016



 Score =  167 bits (423), Expect = 4e-41
 Identities = 171/631 (27%), Positives = 286/631 (45%), Gaps = 58/631 (9%)

Query: 61   DPEGDPISYHISFDPSTRSVFSVDPTFGNI-TLVEELDREREDEIEAIISISDGL--NLV 117
            +P  +P+ YHI  +P  R  F +  T G + T     DRE+++  + ++ +++    + V
Sbjct: 2006 NPINEPLFYHI-LNPDRR--FKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAV 2062

Query: 118  AEKVV-ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN 176
            A  VV ++V D ND AP F+  PY A+V  D   G +I  V AVDRD+G  G V Y+L+ 
Sbjct: 2063 AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKE 2122

Query: 177  LHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNV 236
             H  F +    G + L+    LD   ++ + +TVVAKDGG     A+V+   T       
Sbjct: 2123 HHEHFQIG-PLGEISLKKQFELD-TLNKEYLVTVVAKDGGNPAFSAEVIVPITV------ 2174

Query: 237  EDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEI 295
              +    PVF    Y   + E     S V+ V A   +  K   + YS+ +G+    F I
Sbjct: 2175 --MNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLK---VFYSITDGDPFSQFTI 2229

Query: 296  NETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYG 355
            N  +G I++           Y+L ++ T+        A A V V I + D+N++PP F  
Sbjct: 2230 NFNTGVINVIAPLDFEAHPAYKLSIRATD----SLTGAHAEVFVDIIVDDINDNPPVF-- 2283

Query: 356  ESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLN 415
                Q  + ++++E    G  +  +++   DSD   N   + Q+ G             +
Sbjct: 2284 ---AQQSYAVTLSEASVIGTSV--VQVRATDSDSEPNRGISYQMFGNHS----KSHDHFH 2334

Query: 416  EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
                T ++     +D+E+S+  T  + AV+   P   SS   V + + D NDN P F+  
Sbjct: 2335 VDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMP-TLSSDVIVTVDVTDLNDNPPLFEQQ 2393

Query: 476  YYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWA 534
             Y ARI E+AP G  V  V A D D+    +++YS   G     F+I  +TG+I     +
Sbjct: 2394 IYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGII---TLS 2450

Query: 535  SLDAEATARYNFYVKAEDMEGKY-SVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP--- 590
            +L   A   + + +     +G + S  +V +T++  N H P F ++  +  +    P   
Sbjct: 2451 NLHRHALKPF-YSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHT 2509

Query: 591  --VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGR 648
              ++++  D D+    + V Y I +    + F IN        +  I +L+ L   TP  
Sbjct: 2510 LVMEVKTTDGDSGIYGH-VTYHIVNDFAKDRFYINE-------RGQIFTLEKLDRETPAE 2561

Query: 649  DCLWSLEVQAKDRGSP-SFSTTALLKIDITD 678
              + S+ + AKD G   +F T  ++  D  D
Sbjct: 2562 KVI-SVRLMAKDAGGKVAFCTVNVILTDDND 2591



 Score =  154 bits (388), Expect = 4e-37
 Identities = 163/665 (24%), Positives = 291/665 (43%), Gaps = 82/665 (12%)

Query: 78   RSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQ 137
            ++ FS++   G I+++E + R++    E  ++ SD     + KV++ V  AN   P F Q
Sbjct: 408  KAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSD--RKASTKVLVKVLGANSNPPEFTQ 465

Query: 138  EPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNL-HSPFAVDRHSGVLRLQAGA 196
              Y A   E++P G+ +  + AVD D G  G VTY + NL H PFA+D  +G   +    
Sbjct: 466  TAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGA--VSTSE 523

Query: 197  TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
             LDYE     Y   +     G  +  +V   AT T    + ++ D  P+F      G + 
Sbjct: 524  NLDYELMPRVYTLRIRASDWGLPYRREVEVLATIT----LNNLNDNTPLFEKINCEGTIP 579

Query: 257  EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQ---LQ 312
             D   G ++  V A+D D  +   + Y +  GN+   F +N  SG +S+ +S       +
Sbjct: 580  RDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637

Query: 313  REVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPP--------------TFYGES 357
               + L +  T+     +P     TV  + ++V+L                     + + 
Sbjct: 638  VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697

Query: 358  GPQNRF--ELSMNEHPPQ--GEILRGLKITVN-------------DSDQGANAKFNLQLV 400
              ++ F    S+N H PQ    +  G+++  N             D D G N K    + 
Sbjct: 698  EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757

Query: 401  GPR--GIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADV 458
            G      F +  +T +        ++  + +D E +   T  +   ++  P+K ++   +
Sbjct: 758  GGNEDSCFMIDMETGM--------LKILSPLDRETTDKYTLNITVYDLGIPQK-AAWRLL 808

Query: 459  VIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADL 518
             + ++D NDN P+F    Y   + E+    S ++ V A D D GP G V YS   T  D 
Sbjct: 809  HVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV-TDTDT 867

Query: 519  FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK----YSVAEVFITLLDVNDHPP 574
            F I   TG++       LD E    ++  ++A D   +    +S   V ++L DVND+PP
Sbjct: 868  FSIDSVTGVVNIA--RPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925

Query: 575  QF----GKSVQKKTMVLGTPVK-IEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEI 629
             F     +   ++ +  GT +  +EA D D  + +  V YS+      N FD++  +G +
Sbjct: 926  TFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ-SGQVRYSLLDHGEGN-FDVDKLSGAV 983

Query: 630  WLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSP-SFSTTALLKIDITDAETLSRSPMA 688
             +   ++ LD        +  +++L V+AKD+G P S S+T  +++++ D       P+ 
Sbjct: 984  RI---VQQLDF------EKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVF 1034

Query: 689  AFLIQ 693
            +  ++
Sbjct: 1035 SSFVE 1039



 Score =  141 bits (355), Expect = 3e-33
 Identities = 174/666 (26%), Positives = 277/666 (41%), Gaps = 73/666 (10%)

Query: 46   EDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            E+T  G+ +  +  TD +      I Y  S   S    FS++   G I L + LDRE + 
Sbjct: 3136 ENTEPGTLLTRVQATDADAGLNRKILY--SLIDSADGQFSINELSGIIQLEKPLDRELQA 3193

Query: 103  EIE-AIISISDGL--NLVAEKVVIL-VTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVH 158
                ++ ++  GL   L A   VI+ V D ND  P F    Y A V EDI  G+ + +V+
Sbjct: 3194 VYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVY 3253

Query: 159  AVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            A  RD  +   +TY +   N H  F++D  +G + +     LDYE S  +Y+TV A DGG
Sbjct: 3254 AASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGG 3311

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                      S   TV VNV D+ D  PVF    Y   + ED +    V+ V+A D D  
Sbjct: 3312 ------TPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGP 3365

Query: 277  KPNRILYSLVNGNDGA-FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQA 335
              + I YS+++GN G+ F I+   G + +T+    L RE    +    + S  GSP    
Sbjct: 3366 SNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKL---LDRETISGYTLTVQASDNGSPPRVN 3422

Query: 336  TVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKF 395
            T  V I + D+N++ P F      +  + + + E+ P G  +  L +T  DS       F
Sbjct: 3423 TTTVNIDVSDVNDNAPVF-----SRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFF 3477

Query: 396  NLQLVG-PRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEV--NTPEKF 452
               + G     F V PQ VL           S+AI   K K     LL V+V  N   + 
Sbjct: 3478 FTIVTGNDEKAFEVNPQGVLL---------TSSAI---KRKEKDHYLLQVKVADNGKPQL 3525

Query: 453  SSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY 512
            SS   + I++++ +   P    L            G  +  + A D D   +  + YS  
Sbjct: 3526 SSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV--YDTLTYSLD 3583

Query: 513  GTGADLFLIHPSTGLI----------YTQPWASLDAEATARYNFYVKAEDMEGK---YSV 559
                +LF +  + G +          Y    +  D + T   +  V    +  +   +++
Sbjct: 3584 PQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTI 3643

Query: 560  AEVFITLLD---VNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEP 616
            A  F  L     V D+   F ++++    V    ++I ++   + EP+  +D  +   +P
Sbjct: 3644 AIRFANLTPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQ--SSEPHPHLDVLLFVEKP 3701

Query: 617  AN--------VFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSL--EVQAKDRGSPSF 666
             +        +  INS   +I     +R L+    +  G DC W    E  + D    S 
Sbjct: 3702 GSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDESVMST 3761

Query: 667  STTALL 672
             +TA L
Sbjct: 3762 HSTARL 3767



 Score =  139 bits (350), Expect = 1e-32
 Identities = 164/621 (26%), Positives = 275/621 (44%), Gaps = 71/621 (11%)

Query: 81   FSVDPTFGNITLVE--ELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQE 138
            F + P  G I+L +  ELD   ++ +  +++   G    + +V++ +T  N   P F + 
Sbjct: 2127 FQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKP 2185

Query: 139  PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGA 196
             Y A + E I   S +  V A   ++  G  V Y + +    S F ++ ++GV+ + A  
Sbjct: 2186 FYSAEIAESIQVHSPVVHVQA---NSPEGLKVFYSITDGDPFSQFTINFNTGVINVIA-- 2240

Query: 197  TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
             LD+E    + +++ A D    L GA     A   V + V+D+ D  PVF    Y   + 
Sbjct: 2241 PLDFEAHPAYKLSIRATDS---LTGAH----AEVFVDIIVDDINDNPPVFAQQSYAVTLS 2293

Query: 257  EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETSGAISITQSPAQLQ 312
            E ++ G+ V++V A D D  +PNR +   + GN       F ++ ++G IS+ ++    Q
Sbjct: 2294 EASVIGTSVVQVRATDSD-SEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQ 2352

Query: 313  REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPP 372
               + + V+  +    G P   + V VT+ + DLN++PP F      Q  +E  ++EH P
Sbjct: 2353 SRQHTIFVRAVD---GGMPTLSSDVIVTVDVTDLNDNPPLF-----EQQIYEARISEHAP 2404

Query: 373  QGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 432
             G  +  +K    DS      ++++        F      V++ A   I + N       
Sbjct: 2405 HGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHF------VIDSATGIITLSN-----LH 2453

Query: 433  KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
            +  +  F  L + V+    F S+  V + ++  N + P F    Y   + ENAP  + V+
Sbjct: 2454 RHALKPFYSLNLSVSDGV-FRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM 2512

Query: 493  AVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAE 551
             V   D D+G +G V Y      A D F I+   G I+T      +  A    +  + A+
Sbjct: 2513 EVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQIFTLEKLDRETPAEKVISVRLMAK 2571

Query: 552  DMEGKYSVAEVFITLLDVNDHPPQF---------GKSVQKKTMVLGTPVKIEAIDEDAEE 602
            D  GK +   V + L D ND+ PQF         G S  K T V    VK+ A D D E 
Sbjct: 2572 DAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSV----VKVLASDAD-EG 2626

Query: 603  PNNLVDYSITHAEPANV---FDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAK 659
             N  + Y+I  A+  +V    +IN  +G I  K S+  L+         +  ++  V+A 
Sbjct: 2627 SNADITYAI-EADSESVKENLEINKLSGVITTKESLIGLE---------NEFFTFFVRAV 2676

Query: 660  DRGSPSFSTTALLKIDITDAE 680
            D GSPS  +  L+ + I   E
Sbjct: 2677 DNGSPSKESVVLVYVKILPPE 2697



 Score =  138 bits (348), Expect = 2e-32
 Identities = 162/664 (24%), Positives = 300/664 (45%), Gaps = 93/664 (14%)

Query: 46   EDTPVGSHVYTLNGTDPEG---DPISYHISFDPSTRSVFSVDPTFGNITLVE-ELDRERE 101
            E++P    V  +   DP+    D + Y I+   + +  FS+ P  G IT    +LDRE++
Sbjct: 1150 ENSPKDVSVVQIEAFDPDSSSNDKLMYKIT-SGNPQGFFSIHPKTGLITTTSRKLDREQQ 1208

Query: 102  DEIEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG------- 151
            DE    ++++D  +       +V++ + D ND  P+F+Q+ Y   +PE            
Sbjct: 1209 DEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268

Query: 152  SIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVL---RLQAGATLDYERSRTH 206
              ++ V A D+D G    ++Y ++  N H  F ++  +GV+   R  A    D       
Sbjct: 1269 EPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI------ 1322

Query: 207  YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ----DMAPVFVGTPYYGYVYEDTLPG 262
             +++ A D G            ++T  +++E +      + P+     ++ +   ++ P 
Sbjct: 1323 -LSIKAVDNGRP--------QKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPV 1373

Query: 263  SEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQ 321
            + ++ V++++   G P  + + +  GN D  F++++ +G I + +     Q+  Y L V+
Sbjct: 1374 AHMIGVISVEPP-GIP--LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVE 1430

Query: 322  VTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP-PQGEILRGL 380
             T+ +            V I+++D N+H P F       +++E+ + E   P+ EIL+  
Sbjct: 1431 ATDGTTT------ILTQVFIKVIDTNDHRPQF-----STSKYEVVIPEDTAPETEILQ-- 1477

Query: 381  KITVNDSDQGANAKFNLQLV-GPRGI--FRVVPQTVLNEAQVTIIVENSAAIDFEKSKVL 437
             I+  D D+     + LQ    P  +  FR+ P T          +  S  +D E     
Sbjct: 1478 -ISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGS--------LYTSEKLDHEAVHQH 1528

Query: 438  TFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAV 497
            T  ++  + + P K  + A +V+ + DTND+ P F +  Y  R+ E+A  GS V+ VTA+
Sbjct: 1529 TLTVMVRDQDVPVK-RNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTAL 1587

Query: 498  DPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK 556
            D D G   EV YS   G   + F+I P  G I T     LD    A Y+  VKA D +G 
Sbjct: 1588 DKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTA--KELDRSNQAEYDLMVKATD-KGS 1644

Query: 557  YSVAE-----VFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEA-IDEDAEEPNNLVDYS 610
              ++E     +F+T+ D  +  P+F  + ++ ++ L   V I + +        + V Y 
Sbjct: 1645 PPMSEITSVRIFVTIAD--NASPKF--TSKEYSVELSETVSIGSFVGMVTAHSQSSVVYE 1700

Query: 611  ITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTA 670
            I      + FDIN H+G I  + ++   + L         +++L +Q  +    S +TT 
Sbjct: 1701 IKDGNTGDAFDINPHSGTIITQKAL-DFETLP--------IYTLIIQGTNMAGLSTNTTV 1751

Query: 671  LLKI 674
            L+ +
Sbjct: 1752 LVHL 1755



 Score =  124 bits (310), Expect = 5e-28
 Identities = 160/657 (24%), Positives = 278/657 (42%), Gaps = 81/657 (12%)

Query: 46   EDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            E   VGS V  +   D +      + Y I       S F +DP  G+I   +ELDR  + 
Sbjct: 1573 ESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNS-FMIDPVLGSIKTAKELDRSNQA 1631

Query: 103  EIEAIISISD-GLNLVAE--KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
            E + ++  +D G   ++E   V I VT A++ +P+F  + Y   + E +  GS +  V A
Sbjct: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691

Query: 160  VDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGG 217
                  S  SV Y ++  N    F ++ HSG +  Q    LD+E    + + +   +  G
Sbjct: 1692 -----HSQSSVVYEIKDGNTGDAFDINPHSGTIITQKA--LDFETLPIYTLIIQGTNMAG 1744

Query: 218  RLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLK-------VVA 270
                     S  TTV V+++D  D APVF+   Y G + E     S VL        + A
Sbjct: 1745 --------LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRA 1796

Query: 271  MDGDRGKPNRILYSLVNGNDGA-FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
             D D+     ++Y +V  +    F I+ ++GAI    S    +  ++   VQV +M   G
Sbjct: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDM---G 1853

Query: 330  SPA--AQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLK-ITVND 386
            +P   A+    VT+ ++D+N+ PP F   + P     L +  +       +G+K ITVN 
Sbjct: 1854 TPRLFAEYAANVTVHVIDINDCPPVF---AKPLYEASLLLPTY-------KGVKVITVNA 1903

Query: 387  SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEV 446
            +D  ++A   L          +   T  N  +   +   + A+  + +  L  +      
Sbjct: 1904 TDADSSAFSQL----------IYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVR 1953

Query: 447  NTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
             +  +F+    V I + ++ ++  KF    Y A + EN+    ++  +TA+     P  E
Sbjct: 1954 ASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIG---NPINE 2010

Query: 507  VKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITL 566
              +         F I  ++G++ T      D E    ++  V+  +     +VA V + +
Sbjct: 2011 PLFYHILNPDRRFKISRTSGVLST-TGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKV 2069

Query: 567  L--DVNDHPPQFGK----SVQKKTMVLGTPVK-IEAIDEDAEEPNNLVDYSITHAEPANV 619
            +  D ND+ P F      +V K    +G  ++ + A+D D+     +  Y   H E   +
Sbjct: 2070 IVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQI 2129

Query: 620  FDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDI 676
              +    GEI LK     LD L+         + + V AKD G+P+FS   ++ I +
Sbjct: 2130 GPL----GEISLKKQF-ELDTLNK-------EYLVTVVAKDGGNPAFSAEVIVPITV 2174



 Score =  109 bits (273), Expect = 1e-23
 Identities = 155/642 (24%), Positives = 250/642 (38%), Gaps = 135/642 (21%)

Query: 96  LDREREDEIEAII-SISDGLNLVAE-KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSI 153
           L+RE +D    I+ ++    N+ A  KV + V D ND  P F    Y   +PE+    + 
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167

Query: 154 IFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
           I +V A D D G+ G   Y  ++    FA+   SGV+ L     LDY  ++ + + ++A 
Sbjct: 168 IARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLT--GRLDYLETKLYEMEILAA 225

Query: 214 DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT----------PYYGYVYED----- 258
           D G +L+G+  + S+   +TV++E   + APV              P Y  V  D     
Sbjct: 226 DRGMKLYGSSGI-SSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTVDDCDQG 284

Query: 259 -----------------------TLPGSEVLKVVAMDGDRGKPNRILYSLV-----NGND 290
                                  + PGS+  KV A+ G     +   Y+L       G  
Sbjct: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTP 344

Query: 291 GAFE----INETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDL 346
             F     I+ TS        P + +++VY    +++E +P  +P       V ++ +  
Sbjct: 345 PQFSSVKVIHVTSP--QFKAGPVKFEKDVY--RAEISEFAPPNTPV------VMVKAIPA 394

Query: 347 NNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIF 406
            +H    +  +  + +F L+ N          GL   +    +   A F L++       
Sbjct: 395 YSHLRYVFKSTPGKAKFSLNYN---------TGLISILEPVKRQQAAHFELEV------- 438

Query: 407 RVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTN 466
                                  D + S  +  K+L    N PE F+ TA          
Sbjct: 439 --------------------TTSDRKASTKVLVKVLGANSNPPE-FTQTA---------- 467

Query: 467 DNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTG 526
                     Y A   EN P G++V++++AVDPD G  G V YS        F I   TG
Sbjct: 468 ----------YKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTG 517

Query: 527 LIYTQPWASLDAEATAR-YNFYVKAEDMEGKY-SVAEVF--ITLLDVNDHPPQFGKSVQK 582
            + T    +LD E   R Y   ++A D    Y    EV   ITL ++ND+ P F K   +
Sbjct: 518 AVSTS--ENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCE 575

Query: 583 KTMV--LGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDA 640
            T+   LG   +I  +     +   LV Y I      + F +N ++G + LK S+  +D 
Sbjct: 576 GTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL--MDG 633

Query: 641 LHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETL 682
           L      +    SL + A D    +F+T   + I +  +  L
Sbjct: 634 L----GAKVSFHSLRITATD--GENFATPLYINITVAASHKL 669



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 157/708 (22%), Positives = 272/708 (38%), Gaps = 120/708 (16%)

Query: 43  SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERE 101
           SLPE+T + + +  ++ TD + G    ++ SF   T  +F++ PT G I L   LD    
Sbjct: 157 SLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-DMFAIHPTSGVIVLTGRLDYLET 215

Query: 102 DEIEAIISISD-GLNLVAE-------KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSI 153
              E  I  +D G+ L          K+ + +  AN+ AP       V L P ++     
Sbjct: 216 KLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA---VTLSPSELDRDPA 272

Query: 154 IFKVHAVDRDTGSGG---SVTYFLQNLHSPFAVDRH---SGVLRLQAGATLDYERSRTHY 207
              V   D D G+ G   S++    +L   F   R    S   +++A   +D++     Y
Sbjct: 273 YAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGY 332

Query: 208 -ITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL 266
            +T+ AKD      G    FS+   + V     +     F    Y   + E   P + V+
Sbjct: 333 NLTLQAKD-----KGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVV 387

Query: 267 KVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMS 326
            V A+        R ++    G    F +N  +G ISI +   + Q   +EL V  ++  
Sbjct: 388 MVKAIPAYSHL--RYVFKSTPGK-AKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR- 443

Query: 327 PAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
                  +A+  V ++++  N++PP F      Q  ++ + +E+ P G  +  L     D
Sbjct: 444 -------KASTKVLVKVLGANSNPPEF-----TQTAYKAAFDENVPIGTTVMSLSAV--D 489

Query: 387 SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFE-KSKVLTFKLLAVE 445
            D+G N      +         VP  +      T  V  S  +D+E   +V T ++ A +
Sbjct: 490 PDEGENGYVTYSIAN----LNHVPFAI---DHFTGAVSTSENLDYELMPRVYTLRIRASD 542

Query: 446 VNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWG 505
              P +        I L + NDN P F+ +     IP +   G  +  V+A+D D     
Sbjct: 543 WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD----- 597

Query: 506 EVKYSTY----GTGADLFLIHPSTGLIYTQ-----------PWASLDAEATARYNF---- 546
           E++   Y    G   D F ++P++G++  +            + SL   AT   NF    
Sbjct: 598 ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657

Query: 547 -----------------------------YVKAEDMEGKYSVAEVFITLLDVNDHPPQF- 576
                                         ++A  +  +  V ++F     VN H PQF 
Sbjct: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717

Query: 577 -----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWL 631
                G  V++   V  + + + + D D      LV Y+++     + F I+  TG    
Sbjct: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLV-YAVSGGNEDSCFMIDMETG---- 772

Query: 632 KNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDA 679
              ++ L  L   T  +   ++L +   D G P  +   LL + + DA
Sbjct: 773 --MLKILSPLDRETTDK---YTLNITVYDLGIPQKAAWRLLHVVVVDA 815



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 69/262 (26%), Positives = 113/262 (43%), Gaps = 22/262 (8%)

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
           N+A ++ E     T  + A+E NT     +   V +Q+LDTND  P F    Y   +PEN
Sbjct: 104 NTAILNREVKDHYTLIVKALEKNT--NVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPEN 161

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
               +S+  V+A D D G  GE  YS +    D+F IHP++G+I       LD   T  Y
Sbjct: 162 TAIRTSIARVSATDADIGTNGEFYYS-FKDRTDMFAIHPTSGVIVLT--GRLDYLETKLY 218

Query: 545 NFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIE--------AI 596
              + A D   K   +    ++  +  H  Q  +     T V  +P +++         +
Sbjct: 219 EMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTV 278

Query: 597 DE-DAEEPNNLVDYSITHAEPANVF-DINSHTGEIWLK-NSIRSLDALHNITPGRDCLWS 653
           D+ D     ++   SI   +    F  + S  G    K  +I  +D            ++
Sbjct: 279 DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGID-----WDSHPFGYN 333

Query: 654 LEVQAKDRGS-PSFSTTALLKI 674
           L +QAKD+G+ P FS+  ++ +
Sbjct: 334 LTLQAKDKGTPPQFSSVKVIHV 355


>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
          Length = 4981

 Score =  218 bits (554), Expect = 2e-56
 Identities = 190/656 (28%), Positives = 302/656 (46%), Gaps = 58/656 (8%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISY--HISFDPSTRSVFSVDPTFGNITLVEELDRERE 101
            +PE+TP+ + V+    TDP+  P SY  +   +P     FS+    G + L  ELDRE  
Sbjct: 2059 IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK-FSIGTIDGEVRLTGELDREEV 2117

Query: 102  DEIEAIISISD----GLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
                  +  +D     L+   E VV++V D ND  P F Q  Y   + E+   G+ I +V
Sbjct: 2118 SNYTLTVVATDKGQPSLSSSTE-VVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQV 2176

Query: 158  HAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDG 215
             A D D G+ G V Y + N   +  F +D  +G + +     LD E++ T+++TV A D 
Sbjct: 2177 FAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITV--AKPLDREKTPTYHLTVQATDR 2234

Query: 216  GGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYED--TLPGSEVLKVVAMDG 273
            G          + T+TV++ + D+ D  PVF  +PY   V E+  TLP + +L+VVA D 
Sbjct: 2235 GSTPR------TDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT-ILQVVARDD 2287

Query: 274  DRGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPA 332
            DRG  +++ Y L  GN D AF ++  SG + +TQS   L RE  E  V +   + +GSPA
Sbjct: 2288 DRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVTQS---LDRETKERFVLMITATDSGSPA 2343

Query: 333  AQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN 392
               T  + + + D+N++ PTF  ++     +  ++ E  P G  +    + VN SD  A+
Sbjct: 2344 LTGTGTINVIVDDVNDNVPTFASKA-----YFTTIPEDAPTGTDV----LLVNASDADAS 2394

Query: 393  AKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKF 452
                ++++G    F + P T     Q+      SA +D E     T  ++  +  +PE  
Sbjct: 2395 KNAVIRIIGGNSQFTINPST----GQII----TSALLDRETKDNYTLVVVCSDAGSPEPL 2446

Query: 453  SSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY 512
            SS+  V++ + D NDN P+F    YV  IP     GS V AVT  D D GP  E+ YS  
Sbjct: 2447 SSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLS 2506

Query: 513  GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDH 572
            G  ++ F I P  G I       L+  +   ++ +VK      K     V +  ++  D 
Sbjct: 2507 GRNSEKFHIDPLRGAIMAA--GPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADF 2564

Query: 573  PPQFGKSVQKKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWL 631
            P    K  Q        PV  +      +      + Y I      N F I+  TG++ +
Sbjct: 2565 PKVRAKE-QTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSI 2623

Query: 632  KNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRSPM 687
               +   + +         +W   ++A+D G P FS+    K+DIT  +    +P+
Sbjct: 2624 SQPL-DFEKIQKYV-----VW---IEARDGGFPPFSSYE--KLDITVLDVNDNAPI 2668



 Score =  203 bits (516), Expect = 6e-52
 Identities = 184/654 (28%), Positives = 297/654 (45%), Gaps = 53/654 (8%)

Query: 38   NMALFSLPEDTPVGSHVYTLNGTDP-EGDPISYHISFDPSTRSVFSVDPTFGNITLVEEL 96
            +M   ++ E+   GS +  L   D  EG       +        F +DP  G++     L
Sbjct: 1743 DMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRL 1802

Query: 97   DREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFK 156
            DRER  +   ++   DGL     ++ I V+D ND  P+F +  Y   +PED   GS++  
Sbjct: 1803 DRERRSKYSLLVRADDGLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAA 1862

Query: 157  VHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 214
            + A D D+G  G +TY +   +    F ++  +GV  L     LDYE  + + +TV A+D
Sbjct: 1863 ILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLT--RLLDYEVQQYYILTVRAED 1920

Query: 215  GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGD 274
            GGG+          T  V  N+ DV D  P+F    Y   + E+   GS VL     D D
Sbjct: 1921 GGGQF--------TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDAD 1972

Query: 275  RGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 333
             G  +++ YS+ +G+  G F +++ +G + + ++  +  +  Y L VQV ++    +   
Sbjct: 1973 DGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRF 2031

Query: 334  QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
             +T  V+I ++D+N++PPTF     P+  +   + E+ P   ++   K    D D G N+
Sbjct: 2032 TSTAQVSIILLDVNDNPPTFL---SPKLTY---IPENTPIDTVV--FKAQATDPDSGPNS 2083

Query: 394  KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS 453
                 L+ P G  +    T+  E ++T        +D E+    T  ++A +   P   S
Sbjct: 2084 YIEYTLLNPLG-NKFSIGTIDGEVRLT------GELDREEVSNYTLTVVATDKGQP-SLS 2135

Query: 454  STADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TY 512
            S+ +VV+ +LD NDN P F    Y   I EN   G+ ++ V A D D G  G+V+Y    
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195

Query: 513  GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVN 570
            G     F I   TG I       LD E T  Y+  V+A D     +   + V I LLD+N
Sbjct: 2196 GNTNQEFRIDSVTGAITVA--KPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIN 2253

Query: 571  DHPPQFGKSVQKKTMV--LG----TPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINS 624
            D  P F  S     +   LG    T +++ A D+D    N+ + Y +      N F + S
Sbjct: 2254 DFVPVFELSPYSVNVPENLGTLPRTILQVVARDDD-RGSNSKLSYVLFGGNEDNAFTL-S 2311

Query: 625  HTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
             +GE+ +  S      L   T  R   + L + A D GSP+ + T  + + + D
Sbjct: 2312 ASGELGVTQS------LDRETKER---FVLMITATDSGSPALTGTGTINVIVDD 2356



 Score =  195 bits (495), Expect = 2e-49
 Identities = 168/605 (27%), Positives = 279/605 (46%), Gaps = 45/605 (7%)

Query: 44   LPEDTPVGSHVYTLNGTDPEG--DPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERE 101
            +PE++P+G  V  +  +D +   + IS +   D S    F+++P+ G+I +   L+RE  
Sbjct: 2781 VPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNREDT 2838

Query: 102  DEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
            D     +S  D    V+  V I VTD ND APRF +  Y    PE    GS + +V A D
Sbjct: 2839 DRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATD 2898

Query: 162  RDTGSGGSVTYFLQNLHSPFAVDRHSG------VLRLQAGATLDYERSRTHYITVVAKDG 215
             D GS G V YF+++    F ++  +G      +L+ Q            H   V + D 
Sbjct: 2899 PDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR 2958

Query: 216  GGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG-D 274
            G           + TTVT+N+ D  D AP F+ + Y+  V ++   G+++++V A+D  D
Sbjct: 2959 G------KPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKD 3012

Query: 275  RGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 333
             G  + + Y + N N  G F+++  +G IS+  S      + + + V   +    G+P  
Sbjct: 3013 FGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKD---KGNPPL 3069

Query: 334  QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
             +   V I + + N H P F      Q+    ++ E    G I+R +     D+      
Sbjct: 3070 SSQATVHITVTEENYHTPEF-----SQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLI 3124

Query: 394  KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS 453
            K+++      GIF +   T         I+  + A+D+E  +     + A++     + +
Sbjct: 3125 KYSISSGNEEGIFAINSSTG--------ILTLAKALDYELCQKHEMTISAIDGGWVAR-T 3175

Query: 454  STADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYG 513
                V + ++D NDN P F S  Y   + ENAP G++V+ + A D D+G    + Y+   
Sbjct: 3176 GYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQS 3235

Query: 514  TGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM--EGKYSVAEVFITLLDVND 571
            + +DLF+I P+TG+I TQ +  LD E    Y+  VKA ++  E + S A V I L   N+
Sbjct: 3236 SDSDLFVIDPNTGVITTQGF--LDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNE 3293

Query: 572  HPPQFGKSVQ----KKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHT 626
            + P+F   +      +    GT V ++ A D D       V Y I        F IN  T
Sbjct: 3294 YVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGE-VHYLIFGNSRKKGFQINKKT 3352

Query: 627  GEIWL 631
            G+I++
Sbjct: 3353 GQIYV 3357



 Score =  192 bits (489), Expect = 9e-49
 Identities = 177/618 (28%), Positives = 280/618 (45%), Gaps = 48/618 (7%)

Query: 44  LPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRER 100
           +PED  VGS V  +   D +      I Y +  + +    F +DP  G IT+ E LD E 
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP---FQMDPETGLITVREPLDFEA 315

Query: 101 EDEIEAIISISD----GLNLVAEKVVILVTDANDEAP-----RFIQEPYVALVPEDIPAG 151
             +    +   D     L   AE ++ L+ D ND  P      F      A V E+   G
Sbjct: 316 RRQYSLTVQAMDRGVPSLTGRAEALIQLL-DVNDNDPVVKFRYFPATSRYASVDENAQVG 374

Query: 152 SIIFKVHAVDRDT-GSGGSVTYFL----QNLHSPFAVDRHSGVLRLQAGATLDYERSRTH 206
           +++  +   D D+  + G+++  +    +  H      +   +  ++  + LD ER  ++
Sbjct: 375 TVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSY 434

Query: 207 YITVVAKDGGGRLHGADV-VFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEV 265
            +TV   D  G   GA V   S+  ++ + V D+ D  PVF    Y   + E+  PGS V
Sbjct: 435 NLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV 494

Query: 266 LKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTE 324
             + A DGD G    + YS+V+GN  G F I+E SG ++ T S   L RE+    V    
Sbjct: 495 SGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVT-TGSSGGLDRELASQIVLNIS 553

Query: 325 MSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITV 384
               G     +   + + ++D+N+  P F    G    +++S+ E+ P G  L  L+ T 
Sbjct: 554 ARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEG----YDVSVVENAPTGTELLMLRATD 609

Query: 385 NDSDQGANAKFNLQLVGP-RGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
            D       +F+LQ     R  FR+ P        V+  +   +++D E+    +  +LA
Sbjct: 610 GDLGDNGTVRFSLQEAETDRRSFRLDP--------VSGRLSTISSLDREEQAFYSLLVLA 661

Query: 444 VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGP 503
            ++ +P + SS A + + LLD NDN P F  + Y A I EN PGGS +  V+A DPD G 
Sbjct: 662 TDLGSPPQ-SSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGT 720

Query: 504 WGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYS--VAE 561
            G VKYS        F ++  +G+I T+   +LD E    Y   + A D     S   A 
Sbjct: 721 NGTVKYSISAGDRSRFQVNAQSGVISTR--MALDREEKTAYQLQIVATDGGNLQSPNQAI 778

Query: 562 VFITLLDVNDHPPQFGK----SVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPA 617
           V IT+LD  D+PP F +     V  + + LG    + ++     + N+ + Y IT  +  
Sbjct: 779 VTITVLDTQDNPPVFSQVAYSFVVFENVALG--YHVGSVSASTMDLNSNISYLITTGDQK 836

Query: 618 NVFDINSHTGEIWLKNSI 635
            +F IN  TG++   N I
Sbjct: 837 GMFAINQVTGQLTTANVI 854



 Score =  191 bits (484), Expect = 3e-48
 Identities = 208/704 (29%), Positives = 312/704 (44%), Gaps = 90/704 (12%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGD--PISYHI----SFDPSTRSVFSVDPTFGNITLVEELD 97
            L E  P+G++V ++    P G   P+ Y+I      + +   +F++    G I     LD
Sbjct: 1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697

Query: 98   RERED-----EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGS 152
            RE+       ++ AI   +        +V I + D ND  P F  +     V E+I  GS
Sbjct: 1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757

Query: 153  IIFKVHAVDRDTGSGGSVTY-FLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVV 211
             I ++ A+D D G+   VTY  +      F +D  SG   L A   LD ER   + + V 
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISGADDSFRIDPESG--DLIATRRLDRERRSKYSLLVR 1815

Query: 212  AKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAM 271
            A DG         + S+   + + V DV D  P F    Y   + EDT+PGS V  ++A 
Sbjct: 1816 ADDG---------LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILAT 1866

Query: 272  DGDRGKPNRILYSLVN--GNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
            D D G    I Y +VN    DG F +N  +G  ++T+    L  EV + ++        G
Sbjct: 1867 DDDSGVNGEITY-IVNEDDEDGIFFLNPITGVFNLTR---LLDYEVQQYYILTVRAEDGG 1922

Query: 330  SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
                  T+ V   I+D+N++PP F       N +  S+ E+ P G  +  L   V D+D 
Sbjct: 1923 GQF--TTIRVYFNILDVNDNPPIF-----SLNSYSTSLMENLPVGSTV--LVFNVTDADD 1973

Query: 390  GANAKFNLQLVG--PRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
            G N++    +      G F V    VL   +         A+D E     +F  L V+V+
Sbjct: 1974 GINSQLTYSIASGDSLGQFTVDKNGVLKVLK---------ALDRESQ---SFYNLVVQVH 2021

Query: 448  -----TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTG 502
                    +F+STA V I LLD NDN P F S   +  IPEN P  + V    A DPD+G
Sbjct: 2022 DLPQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSG 2080

Query: 503  PWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVA-- 560
            P   ++Y+      + F I    G +  +    LD E  + Y   V A D +G+ S++  
Sbjct: 2081 PNSYIEYTLLNPLGNKFSIGTIDGEV--RLTGELDREEVSNYTLTVVATD-KGQPSLSSS 2137

Query: 561  -EVFITLLDVNDHPPQFGKSVQK----KTMVLGTP-VKIEAIDEDAEEPNNLVDYSITHA 614
             EV + +LD+ND+ P F +++ K    +  + GT  +++ A D D E  N  V Y I + 
Sbjct: 2138 TEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGD-EGTNGQVRYGIVNG 2196

Query: 615  EPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS---PSFSTTAL 671
                 F I+S TG I +    + LD     TP     + L VQA DRGS      ST ++
Sbjct: 2197 NTNQEFRIDSVTGAITV---AKPLD--REKTP----TYHLTVQATDRGSTPRTDTSTVSI 2247

Query: 672  LKIDITD-AETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVA 714
            + +DI D       SP +        N  + +G L  T+  VVA
Sbjct: 2248 VLLDINDFVPVFELSPYSV-------NVPENLGTLPRTILQVVA 2284



 Score =  187 bits (474), Expect = 5e-47
 Identities = 184/650 (28%), Positives = 290/650 (44%), Gaps = 50/650 (7%)

Query: 42   FSLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRER 100
            F + E+  +G HV +++ +  +    ISY I+     + +F+++   G +T    +DRE 
Sbjct: 800  FVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQ-KGMFAINQVTGQLTTANVIDREE 858

Query: 101  EDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV 160
            +   +  +  S G       V I V D ND +P F+Q      V E+  AG  IF+  AV
Sbjct: 859  QSFYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAV 918

Query: 161  DRDTGSGGSVTYFL-QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRL 219
            D D G  G V Y L QN  + FA++  +G + L     +    + ++ I ++A D G   
Sbjct: 919  DPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDV---HAGSYQIEILASDMG--- 972

Query: 220  HGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPN 279
                   S++  +TV V DV D +PVF    Y   + E     S   KV A D D G   
Sbjct: 973  ---VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANG 1029

Query: 280  RILYSLVNGNDG-AFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVP 338
             I Y++  GN G AF I    G + I    ++L RE+ + +V +   S        ATV 
Sbjct: 1030 EIAYTIAEGNTGDAFGI-FPDGQLYI---KSELDRELQDRYVLMVVASDRAVEPLSATVN 1085

Query: 339  VTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN--AKFN 396
            VT+ + D+N++ P F         +     E    G  +   K++  D D G N   +++
Sbjct: 1086 VTVILEDVNDNRPLF-----NSTNYTFYFEEEQRAGSFVG--KVSAVDKDFGPNGEVRYS 1138

Query: 397  LQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTA 456
             ++V P      +   + N  Q     +  + +    + V +F ++A +   P+     A
Sbjct: 1139 FEMVQPDFELHAISGEITNTHQ----FDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQA 1194

Query: 457  DVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY-GTG 515
             V + + D NDN PKF   +Y A I E+A   + V+ V+A D D G  G + YS   G  
Sbjct: 1195 TVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNE 1254

Query: 516  ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDME--GKYSVAEVFITLLDVNDHP 573
               F I  ++G +       LD EAT  Y+  ++A D       S   + I +LD ND+ 
Sbjct: 1255 ERQFAIDSTSGQVTL--IGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNT 1312

Query: 574  PQFGKSV----QKKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGE 628
            P F KS       + M +G  V  + A D D+ +  +L  YSIT       F I+ +TG 
Sbjct: 1313 PSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLY-YSITGTNNHGTFSISPNTGS 1371

Query: 629  IWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
            I+L    + LD           L+ L + AKD+G P  S+T  + I + D
Sbjct: 1372 IFL---AKKLDF------ETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412



 Score =  187 bits (474), Expect = 5e-47
 Identities = 168/626 (26%), Positives = 277/626 (44%), Gaps = 54/626 (8%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            +L E  PV S  + +  +D +      I+Y I+ + +T   F + P  G + +  ELDRE
Sbjct: 1004 TLSESEPVNSRFFKVQASDKDSGANGEIAYTIA-EGNTGDAFGIFPD-GQLYIKSELDRE 1061

Query: 100  REDEIEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFK 156
             +D    ++  SD           V +++ D ND  P F    Y     E+  AGS + K
Sbjct: 1062 LQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK 1121

Query: 157  VHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVL----RLQAGATLDYERSRTHYITVVA 212
            V AVD+D G  G V Y  + +   F +   SG +    +    + +    +     TV+A
Sbjct: 1122 VSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIA 1181

Query: 213  KDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMD 272
             D      G         TV V ++D+ D AP F+   Y   + E     ++VL+V A D
Sbjct: 1182 TD-----QGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASD 1236

Query: 273  GDRGKPNRILYSLVNGNDGA-FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP 331
             D G    I YS++ GN+   F I+ TSG +++           Y L +Q  +   +G+ 
Sbjct: 1237 VDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVD---SGTI 1293

Query: 332  AAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGA 391
               +T  + I I+D N++ P+F     P++   + + E+   GE++    +T  DSD G 
Sbjct: 1294 PLNSTCTLNIDILDENDNTPSF-----PKSTLFVDVLENMRIGELVSS--VTATDSDSGD 1346

Query: 392  NAKFNLQLVGPR--GIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
            NA     + G    G F + P T          +  +  +DFE   +    + A +   P
Sbjct: 1347 NADLYYSITGTNNHGTFSISPNTGS--------IFLAKKLDFETQSLYKLNITAKDQGRP 1398

Query: 450  EKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKY 509
             + SST  VVI + D NDN P F        I EN P G+SV++VTA DPD    G++ Y
Sbjct: 1399 PR-SSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY 1457

Query: 510  STYG--TGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM-----EGKYSVAEV 562
            +        + F I    G IYT   A +D E    +   VKA D        +Y++  V
Sbjct: 1458 TIIQQMPRGNHFTIDEVKGTIYTN--AEIDREFANLFELTVKANDQAVPIETRRYALKNV 1515

Query: 563  FITLLDVNDHPPQF----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPAN 618
             I + D+ND+ P F      +     ++      I A D D E  N  ++Y I + +  +
Sbjct: 1516 TILVTDLNDNVPMFISQNALAADPSAVIGSVLTTIMAADPD-EGANGEIEYEIINGD-TD 1573

Query: 619  VFDINSHTGEIWLKNSIRSLDALHNI 644
             F ++ ++G++ + +++     ++N+
Sbjct: 1574 TFIVDRYSGDLRVASALVPSQLIYNL 1599



 Score =  187 bits (474), Expect = 5e-47
 Identities = 184/675 (27%), Positives = 294/675 (43%), Gaps = 79/675 (11%)

Query: 32   VGSTNGNMALFS-------LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD 84
            V   N N+  F+       +PED P G+ V  +N +D   D     +       S F+++
Sbjct: 2354 VDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASD--ADASKNAVIRIIGGNSQFTIN 2411

Query: 85   PTFGNITLVEELDREREDEIEAIISISDGLN----LVAEKVVILVTDANDEAPRFIQEPY 140
            P+ G I     LDRE +D    ++  SD  +      +  V++ VTD ND  PRF   PY
Sbjct: 2412 PSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPY 2471

Query: 141  VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHS-PFAVDRHSGVLRLQAGATLD 199
            V  +P     GS +F V   D D G    + Y L   +S  F +D   G   + A   L+
Sbjct: 2472 VTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGA--IMAAGPLN 2529

Query: 200  YERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDT 259
                 T   +V  KDGG         F  T + TV V  V       V      +++ + 
Sbjct: 2530 GASEVT--FSVHVKDGGS--------FPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPEN 2579

Query: 260  LPGSEVLKVVAMDGDRGKPNRILYSLVNGNDG-AFEINETSGAISITQSPAQLQREVYEL 318
             P S ++  +     RG+P  + Y + +GN G  F+I++ +G +SI+Q    L  E  + 
Sbjct: 2580 QPVSSLVTTITGSSLRGEP--MSYYIASGNLGNTFQIDQLTGQVSISQ---PLDFEKIQK 2634

Query: 319  HVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILR 378
            +V   E    G P   +   + I ++D+N++ P F               E P   EIL 
Sbjct: 2635 YVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIF--------------KEDPFISEILE 2680

Query: 379  GLK------ITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 432
             L       ++  D D G N + + ++V          +   +    T  + +   +D E
Sbjct: 2681 NLSPRKILTVSAMDKDSGPNGQLDYEIVNGN------MENSFSINHATGEIRSVRPLDRE 2734

Query: 433  KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
            K       + + +  +P + S++  V+I +LD NDN P+F  + + A +PEN+P G +V 
Sbjct: 2735 KVSHYVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVT 2792

Query: 493  AVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTG-LIYTQPWASLDAEATARYNFYVKAE 551
             VT  D D G     +YS        F I+PSTG ++ ++P   L+ E T RY   V A 
Sbjct: 2793 RVTTSDEDIGINAISRYSIMDASLP-FTINPSTGDIVISRP---LNREDTDRYRIRVSAH 2848

Query: 552  DMEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNL 606
            D  G     +V I + D+ND+ P+F ++       + T +     ++ A D D E  N  
Sbjct: 2849 D-SGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPD-EGSNGQ 2906

Query: 607  VDYSITHAEPANVFDINSHTGEIWLKNSIR--SLDALHNITPGRDCLWSLEVQAKDRGSP 664
            V Y I     +  F IN+ TGEI+ K  ++  ++    N+   R    S  V + DRG P
Sbjct: 2907 VFYFI--KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRH---SFIVTSSDRGKP 2961

Query: 665  SFSTTALLKIDITDA 679
            S  +   + I+I D+
Sbjct: 2962 SLISETTVTINIVDS 2976



 Score =  175 bits (444), Expect = 1e-43
 Identities = 182/663 (27%), Positives = 288/663 (43%), Gaps = 71/663 (10%)

Query: 45   PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFG-----------NITLV 93
            PE T +GS V  +  TDP+         F  S    F ++ T G           N+T  
Sbjct: 2882 PELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGF 2941

Query: 94   EELDREREDEIEAIISISDGL-NLVAEKVVIL-VTDANDEAPRFIQEPYVALVPEDIPAG 151
              ++  R   I  + S   G  +L++E  V + + D+ND AP+F++  Y   V +++  G
Sbjct: 2942 SNVNINRHSFI--VTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVG 2999

Query: 152  SIIFKVHAVD-RDTGSGGSVTYFLQNLH--SPFAVDRHSGVLRLQAGATLDYERSRTHYI 208
            + + +V A+D +D G    V YF+ N +    F +D  +G + + +    D  ++   +I
Sbjct: 3000 TKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQN--FFI 3057

Query: 209  TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268
            TV AKD G      +   S+  TV + V +     P F  +     + E    GS V  V
Sbjct: 3058 TVTAKDKG------NPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV 3111

Query: 269  VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSP 327
             A D D      I YS+ +GN+ G F IN ++G +++ ++   L  E+ + H        
Sbjct: 3112 SARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKA---LDYELCQKHEMTISAID 3168

Query: 328  AGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDS 387
             G  A      VT+ ++D+N++ P F  +      +  ++ E+ P G  +  L  T  DS
Sbjct: 3169 GGWVARTGYCSVTVNVIDVNDNSPVFLSDD-----YFPTVLENAPSGTTVIHLNATDADS 3223

Query: 388  DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
               A   + +Q      +F + P T         ++     +DFE  +  ++ L     N
Sbjct: 3224 GTNAVIAYTVQS-SDSDLFVIDPNTG--------VITTQGFLDFETKQ--SYHLTVKAFN 3272

Query: 448  TP-EKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
             P E+  S A V IQL  TN+ VP+F S  Y   I E AP G+ V  V A D D G  GE
Sbjct: 3273 VPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGE 3332

Query: 507  VKYSTYGTGADL-FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAE---- 561
            V Y  +G      F I+  TG IY      LD E   R +  V A++  G    A+    
Sbjct: 3333 VHYLIFGNSRKKGFQINKKTGQIYVS--GILDREKEERVSLKVLAKNF-GSIRGADIDEV 3389

Query: 562  -VFITLLDVNDHPPQFGKSVQKKTMVLGTPVK-----IEAIDEDAEEPNNLVDYSITHAE 615
             V +T+LD ND PP F  ++    +  G P+      + A D D+    +   Y I    
Sbjct: 3390 TVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGN 3448

Query: 616  PANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKID 675
                F IN  TG+I +   +          P    +++L V A D G+PS + +A L + 
Sbjct: 3449 ENGAFSINPQTGQITVTAELD-----RETLP----IYNLSVLAVDSGTPSATGSASLLVT 3499

Query: 676  ITD 678
            + D
Sbjct: 3500 LED 3502



 Score =  170 bits (431), Expect = 5e-42
 Identities = 179/686 (26%), Positives = 298/686 (43%), Gaps = 85/686 (12%)

Query: 34  STNGNMALFSLPEDTPVGSHVYTLNGTDP---------EGDPISYHISFDPSTRSVFSVD 84
           S++G   +     D+ +GS     NG D          E       I+ +PS    F   
Sbjct: 148 SSSGRQVILDTATDSDIGS-----NGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAF--- 199

Query: 85  PTFGNITLVEE--LDREREDEIEAIISISDGLNLVAE---KVVILVTDANDEAPRFIQEP 139
                + LV +  LDRE   + + ++ + D          +V + V D ND  P F    
Sbjct: 200 -----LHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSH 254

Query: 140 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLD 199
           Y A VPED   GS + +V A D D G+   + Y LQ+  +PF +D  +G++ ++    LD
Sbjct: 255 YQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVR--EPLD 312

Query: 200 YERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPV-----FVGTPYYGY 254
           +E  R + +TV A D G          +      + + DV D  PV     F  T  Y  
Sbjct: 313 FEARRQYSLTVQAMDRG------VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYAS 366

Query: 255 VYEDTLPGSEVLKVVAMDGDRGKPN-RILYSLVNGNDGA-FEINETS-GAISITQSPAQL 311
           V E+   G+ V  +   D D    N  I   ++ GN+   FE+  +    +S+ +  + L
Sbjct: 367 VDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASAL 426

Query: 312 QRE---VYELHVQVTEM--SPAGS--PAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFE 364
            RE    Y L V V++   +P G+   A  +   + I + D+N+HPP F      Q  + 
Sbjct: 427 DRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVF-----SQQVYR 481

Query: 365 LSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVE 424
           ++++E  P G  + G+  T  DS   AN ++++      G F +      +E    +   
Sbjct: 482 VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI------SEHSGLVTTG 535

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLY-YVARIPE 483
           +S  +D E +  +   + A +     K  S A +V+ LLD ND  P F     Y   + E
Sbjct: 536 SSGGLDRELASQIVLNISARDQGVHPKV-SYAQLVVTLLDVNDEKPVFSQPEGYDVSVVE 594

Query: 484 NAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGAD--LFLIHPSTGLIYTQPWASLDAEAT 541
           NAP G+ ++ + A D D G  G V++S      D   F + P +G + T   +SLD E  
Sbjct: 595 NAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLST--ISSLDREEQ 652

Query: 542 ARYNFYVKAEDMEG--KYSVAEVFITLLDVND-----HPPQFGKSVQKKTMVLGTPVKIE 594
           A Y+  V A D+    + S+A + ++LLD+ND     +P Q+   +++          + 
Sbjct: 653 AFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712

Query: 595 AIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSL 654
           A D D    N  V YSI+  + +  F +N+ +G I   ++  +LD            + L
Sbjct: 713 ATDPDL-GTNGTVKYSISAGDRSR-FQVNAQSGVI---STRMALDREEKTA------YQL 761

Query: 655 EVQAKDRGSPSFSTTALLKIDITDAE 680
           ++ A D G+      A++ I + D +
Sbjct: 762 QIVATDGGNLQSPNQAIVTITVLDTQ 787



 Score =  167 bits (422), Expect = 5e-41
 Identities = 183/667 (27%), Positives = 289/667 (43%), Gaps = 62/667 (9%)

Query: 41  LFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRER 100
           +F + E+ P G    TL GT       +Y +S    + ++F+++ + G +     +DRE 
Sbjct: 48  VFQVLEEQPPG----TLVGTIQTRPGFTYRLS---ESHALFAINSSTGALYTTSTIDRES 100

Query: 101 -EDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
              ++  ++ +S       E V +LV D ND AP F     V    ED  +G  +    A
Sbjct: 101 LPSDVINLVVLSSAPTYPTE-VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTA 159

Query: 160 VDRDTGSGG----SVTYFLQNLHSPFAVD------RHSGVLRLQAGATLDYERSRTHYIT 209
            D D GS G    S      N    F +D           L L +   LD E +  + + 
Sbjct: 160 TDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLL 219

Query: 210 VVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVV 269
           V  +D G      +        V V V+D+ D  PVF  + Y   V ED + GS VL+V 
Sbjct: 220 VEVEDKG------EPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVA 273

Query: 270 AMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
           A D D G    I Y L       F+++  +G I++ +      R  Y L VQ  +    G
Sbjct: 274 AADADEGTNADIRYRL-QDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMD---RG 329

Query: 330 SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
            P+        I+++D+N++ P       P      S++E+   G ++  L +T  DS  
Sbjct: 330 VPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS-P 388

Query: 390 GANAKFNLQLVG--PRGIFRVVPQTVLNEAQVTIIVENSAAIDFEK--SKVLTFKLL--- 442
            AN   ++Q++G   +  F V    V N +    +++ ++A+D E+  S  LT  +    
Sbjct: 389 AANGNISVQILGGNEQRHFEVQSSKVPNLS----LIKVASALDRERIPSYNLTVSVSDNY 444

Query: 443 -AVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDT 501
            A      +  SS A +VI + D ND+ P F    Y   + E AP GS V  ++A D D+
Sbjct: 445 GAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS 504

Query: 502 GPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYS 558
           G    ++YS   G G   F I   +GL+ T     LD E  ++    + A D  +  K S
Sbjct: 505 GLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVS 564

Query: 559 VAEVFITLLDVNDHPPQFGK------SVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSIT 612
            A++ +TLLDVND  P F +      SV +        + + A D D  + N  V +S+ 
Sbjct: 565 YAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGD-NGTVRFSLQ 623

Query: 613 HAE-PANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTAL 671
            AE     F ++  +G +   ++I SLD            +SL V A D GSP  S+ A 
Sbjct: 624 EAETDRRSFRLDPVSGRL---STISSLDR------EEQAFYSLLVLATDLGSPPQSSMAR 674

Query: 672 LKIDITD 678
           + + + D
Sbjct: 675 INVSLLD 681



 Score =  165 bits (418), Expect = 1e-40
 Identities = 178/709 (25%), Positives = 315/709 (44%), Gaps = 69/709 (9%)

Query: 42   FSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERE 101
            F  PE+ PV S V T+ G+   G+P+SY+I+   +  + F +D   G +++ + LD E+ 
Sbjct: 2574 FMFPENQPVSSLVTTITGSSLRGEPMSYYIA-SGNLGNTFQIDQLTGQVSISQPLDFEKI 2632

Query: 102  DEIEAIISISDG---LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVH 158
             +    I   DG        EK+ I V D ND AP F ++P+++ + E++    I+  V 
Sbjct: 2633 QKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVS 2691

Query: 159  AVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            A+D+D+G  G + Y +   N+ + F+++  +G +R  +   LD E+   + +T+ + D G
Sbjct: 2692 AMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIR--SVRPLDREKVSHYVLTIKSSDKG 2749

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                      S +  V +N+ D  D AP F    +  +V E++  G  V +V   D D G
Sbjct: 2750 SPSQ------STSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTRVTTSDEDIG 2802

Query: 277  KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQAT 336
                  YS+++ +   F IN ++G I I++   +   + Y + V       A       +
Sbjct: 2803 INAISRYSIMDAS-LPFTINPSTGDIVISRPLNREDTDRYRIRVS------AHDSGWTVS 2855

Query: 337  VPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFN 396
              VTI + D+N++ P F      +  + L   E    G   +  ++   D D+G+N +  
Sbjct: 2856 TDVTIFVTDINDNAPRF-----SRTSYYLDCPELTEIGS--KVTQVFATDPDEGSNGQVF 2908

Query: 397  LQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTA 456
              +      FR+   T     +  +  +N            +F + + +   P   S T 
Sbjct: 2909 YFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETT 2968

Query: 457  DVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAV-DPDTGPWGEVKY-STYGT 514
             V I ++D+NDN P+F    Y   + +N   G+ ++ VTA+ D D G   EV+Y  +   
Sbjct: 2969 -VTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDN 3027

Query: 515  GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK--YSVAEVFITLLDVNDH 572
                F +   TG I     +SL ++    +   V A+D       S A V IT+ + N H
Sbjct: 3028 HLGKFKLDNDTGWISVA--SSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYH 3085

Query: 573  PPQFGKSVQKKTM----VLGTPVK-IEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTG 627
             P+F +S    T+     +G+ V+ + A D DA   N L+ YSI+      +F INS TG
Sbjct: 3086 TPEFSQSHMSATIPESHSIGSIVRTVSARDRDA-AMNGLIKYSISSGNEEGIFAINSSTG 3144

Query: 628  EIWLKNSI---------RSLDALHNITPGRDCLWSLEVQAKD--RGSPSF---------- 666
             + L  ++          ++ A+      R    S+ V   D    SP F          
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204

Query: 667  ----STTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMAT 711
                S T ++ ++ TDA++   + + A+ +Q+ D+ +  +    G + T
Sbjct: 3205 ENAPSGTTVIHLNATDADS-GTNAVIAYTVQSSDSDLFVIDPNTGVITT 3252



 Score =  156 bits (395), Expect = 7e-38
 Identities = 159/598 (26%), Positives = 264/598 (44%), Gaps = 43/598 (7%)

Query: 46   EDTPVGSHVYTLNGTDPE-GDPISYHISFD-PSTRSVFSVDPTFGNITLVEELDREREDE 103
            E+  +G  V ++  TD + GD    + S    +    FS+ P  G+I L ++LD E +  
Sbjct: 1326 ENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSL 1385

Query: 104  IEAIISISDG---LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV 160
             +  I+  D           VVI V D ND  P F        + E+IP G+ +  V A 
Sbjct: 1386 YKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAH 1445

Query: 161  DRDTGSGGSVTY-FLQNLH--SPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGG 217
            D D    G ++Y  +Q +   + F +D   G +     A +D E +    +TV A D   
Sbjct: 1446 DPDADINGQLSYTIIQQMPRGNHFTIDEVKGTI--YTNAEIDREFANLFELTVKANDQAV 1503

Query: 218  RLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGK 277
             +        A   VT+ V D+ D  P+F+            + GS +  ++A D D G 
Sbjct: 1504 PIETRRY---ALKNVTILVTDLNDNVPMFISQNALA-ADPSAVIGSVLTTIMAADPDEGA 1559

Query: 278  PNRILYSLVNGNDGAFEINETSGAISITQS--PAQLQREVYELHVQVTEMSPAGSPAAQA 335
               I Y ++NG+   F ++  SG + +  +  P+QL   +Y L V  T++ P      ++
Sbjct: 1560 NGEIEYEIINGDTDTFIVDRYSGDLRVASALVPSQL---IYNLIVSATDLGPE---RRKS 1613

Query: 336  TVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKF 395
            T  +TI +  L+   P F      Q ++   + E  P G  +  ++     S +G+ A  
Sbjct: 1614 TTELTIILQGLDG--PVF-----TQPKYITILKEGEPIGTNVISIEAA---SPRGSEAPV 1663

Query: 396  NLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTF-KLLAVEVNTPEKFSS 454
               +V  R   + V + +    + T I++ +A +D E+   L    + A+E +T    + 
Sbjct: 1664 EYYIVSVRCEEKTVGR-LFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQ 1722

Query: 455  TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGT 514
             A+V I L D NDN P F +      + EN   GS ++ +TA+D D G    V Y+    
Sbjct: 1723 RAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG 1782

Query: 515  GADLFLIHPSTG-LIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHP 573
              D F I P +G LI T+    LD E  ++Y+  V+A+D   + S   + IT+ DVNDH 
Sbjct: 1783 ADDSFRIDPESGDLIATR---RLDRERRSKYSLLVRADD-GLQSSDMRINITVSDVNDHT 1838

Query: 574  PQFGKSVQK----KTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTG 627
            P+F + V      +  + G+ V      +D    N  + Y +   +   +F +N  TG
Sbjct: 1839 PKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITG 1896



 Score =  151 bits (381), Expect = 3e-36
 Identities = 175/631 (27%), Positives = 277/631 (43%), Gaps = 62/631 (9%)

Query: 67   ISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLN--LVAEKVV-I 123
            + Y IS D +    F +D   G I++   L  +        ++  D  N  L ++  V I
Sbjct: 3019 VEYFISND-NHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHI 3077

Query: 124  LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPF 181
             VT+ N   P F Q    A +PE    GSI+  V A DRD    G + Y +   N    F
Sbjct: 3078 TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIF 3137

Query: 182  AVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQD 241
            A++  +G+L L     LDYE  + H +T+ A DGG       V  +   +VTVNV DV D
Sbjct: 3138 AINSSTGILTL--AKALDYELCQKHEMTISAIDGGW------VARTGYCSVTVNVIDVND 3189

Query: 242  MAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGA 301
             +PVF+   Y+  V E+   G+ V+ + A D D G    I Y++ + +   F I+  +G 
Sbjct: 3190 NSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGV 3249

Query: 302  ISITQSPAQLQ-REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360
            I+ TQ     + ++ Y L V+   + P     + ATV   I++   N + P F  +    
Sbjct: 3250 IT-TQGFLDFETKQSYHLTVKAFNV-PDEERCSFATV--NIQLKGTNEYVPRFVSKL--- 3302

Query: 361  NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGP--RGIFRVVPQTVLNEAQ 418
              +   ++E  P+G I+   ++  +D D G + + +  + G   +  F++  +T     Q
Sbjct: 3303 --YYFEISEAAPKGTIVG--EVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKT----GQ 3354

Query: 419  VTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS-STADVVIQLLDTNDNVPKFDSLYY 477
            + +    S  +D EK + ++ K+LA    +          V + +LD ND  P F    Y
Sbjct: 3355 IYV----SGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIY 3409

Query: 478  VARIPENAPGGSSVVAVTAVDPDTGP-WGEVKYSTYGTGAD--LFLIHPSTGLIYTQPWA 534
              +I E  P G+ V  V+A D D+ P W    Y   G+G +   F I+P TG I     A
Sbjct: 3410 SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFI-GSGNENGAFSINPQTGQITVT--A 3466

Query: 535  SLDAEATARYNFYVKAEDMEGKYSV--AEVFITLLDVNDHPPQF----GKSVQKKTMVLG 588
             LD E    YN  V A D     +   A + +TL D+ND+ P      G+ ++ K    G
Sbjct: 3467 ELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVMENKRP--G 3524

Query: 589  TPVK-IEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPG 647
            T V  +++ D D         Y +    PA  +   S  G +   ++ R +D        
Sbjct: 3525 TLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVL---STTREIDREQIAD-- 3579

Query: 648  RDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
                + L V  KD G P  S+T  + I + D
Sbjct: 3580 ----FYLSVVTKDSGVPQMSSTGTVHITVID 3606



 Score =  149 bits (377), Expect = 8e-36
 Identities = 150/548 (27%), Positives = 249/548 (45%), Gaps = 46/548 (8%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            ++PE   +GS V T++  D +      I Y IS   +   +F+++ + G +TL + LD E
Sbjct: 3097 TIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS-SGNEEGIFAINSSTGILTLAKALDYE 3155

Query: 100  REDEIEAIISISDGLNLVAE----KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 155
               + E  IS  DG   VA      V + V D ND +P F+ + Y   V E+ P+G+ + 
Sbjct: 3156 LCQKHEMTISAIDG-GWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVI 3214

Query: 156  KVHAVDRDTGSGGSVTYFLQNLHSP-FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 214
             ++A D D+G+   + Y +Q+  S  F +D ++GV+  Q    LD+E  +++++TV A  
Sbjct: 3215 HLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQG--FLDFETKQSYHLTVKA-- 3270

Query: 215  GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGD 274
                 +  D    +  TV + ++   +  P FV   YY  + E    G+ V +V A D D
Sbjct: 3271 ----FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRD 3326

Query: 275  RGKPNRILYSLV-NGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEM-SPAGSPA 332
             G    + Y +  N     F+IN+ +G I ++    + + E   L V      S  G+  
Sbjct: 3327 LGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADI 3386

Query: 333  AQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDS-DQGA 391
             + TV VT+  +D N+ PP F       N + + ++E  P G  +  +    +DS    +
Sbjct: 3387 DEVTVNVTV--LDAND-PPIF-----TLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWS 3438

Query: 392  NAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEK 451
               + +      G F + PQT     Q+T+  E    +D E   +    +LAV+  TP  
Sbjct: 3439 RFSYFIGSGNENGAFSINPQT----GQITVTAE----LDRETLPIYNLSVLAVDSGTPSA 3490

Query: 452  FSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGP-WGEVKYS 510
              S A +++ L D NDN P          + EN   G+ V+ + + DPD  P  G   Y 
Sbjct: 3491 TGS-ASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYY 3547

Query: 511  TYGTG-ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLL 567
               TG A  +    + G++ T     +D E  A +   V  +D  +    S   V IT++
Sbjct: 3548 LLSTGPATSYFSLSTAGVLSTT--REIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVI 3605

Query: 568  DVNDHPPQ 575
            D ND+P Q
Sbjct: 3606 DQNDNPSQ 3613



 Score =  117 bits (293), Expect = 5e-26
 Identities = 127/469 (27%), Positives = 205/469 (43%), Gaps = 45/469 (9%)

Query: 46   EDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            E+ P G+ V  LN TD +      I+Y +    S   +F +DP  G IT    LD E + 
Sbjct: 3205 ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS--DLFVIDPNTGVITTQGFLDFETKQ 3262

Query: 103  EIEAII---SISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
                 +   ++ D        V I +   N+  PRF+ + Y   + E  P G+I+ +V A
Sbjct: 3263 SYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFA 3322

Query: 160  VDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGG 217
             DRD G+ G V Y +   +    F +++ +G  ++     LD E+     + V+AK+ G 
Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKTG--QIYVSGILDREKEERVSLKVLAKNFGS 3380

Query: 218  RLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGK 277
             + GAD+      TV V V D  D  P+F    Y   + E    G+ V  V A D D   
Sbjct: 3381 -IRGADI---DEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIP 3435

Query: 278  P-NRILYSLVNGND-GAFEINETSGAISITQSPAQLQRE---VYELHVQVTEMSPAGSPA 332
              +R  Y + +GN+ GAF IN  +G I++T   A+L RE   +Y L V   +   +G+P+
Sbjct: 3436 SWSRFSYFIGSGNENGAFSINPQTGQITVT---AELDRETLPIYNLSVLAVD---SGTPS 3489

Query: 333  AQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN 392
            A  +  + + + D+N++ P      G     E+  N+ P  G ++  L+ T  D D   N
Sbjct: 3490 ATGSASLLVTLEDINDNGPMLTVSEG-----EVMENKRP--GTLVMTLQST--DPDLPPN 3540

Query: 393  -AKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEK 451
               F   L+         P T         ++  +  ID E+       ++  +   P+ 
Sbjct: 3541 QGPFTYYLLS------TGPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQ- 3593

Query: 452  FSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD 500
             SST  V I ++D NDN  +  ++        N   G  + +V   DPD
Sbjct: 3594 MSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD 3642



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 62/238 (26%), Positives = 99/238 (41%), Gaps = 21/238 (8%)

Query: 38   NMALFSLPEDTPVGSHVYTLNGTDPEGDP----ISYHISFDPSTRSVFSVDPTFGNITLV 93
            N+    + E  P+G+HV  ++  D +  P     SY I    +    FS++P  G IT+ 
Sbjct: 3407 NIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIG-SGNENGAFSINPQTGQITVT 3465

Query: 94   EELDREREDEIE-AIISISDGLNLVAEKVVILVT--DANDEAPRFIQEPYVALVPEDIPA 150
             ELDRE       +++++  G         +LVT  D ND  P          V E+   
Sbjct: 3466 AELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSE--GEVMENKRP 3523

Query: 151  GSIIFKVHAVDRD-TGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYIT 209
            G+++  + + D D   + G  TY+L +     +    S    L     +D E+    Y++
Sbjct: 3524 GTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYLS 3583

Query: 210  VVAKDGGGRLHGADVVFSATTTVTVNVEDVQD----MAPVFVGTPYYGYVYEDTLPGS 263
            VV KD G          S+T TV + V D  D       V +   YYG ++   + GS
Sbjct: 3584 VVTKDSG------VPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGS 3635


>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
          Length = 530

 Score =  212 bits (539), Expect = 1e-54
 Identities = 163/499 (32%), Positives = 248/499 (49%), Gaps = 40/499 (8%)

Query: 8   ALALGLLRLCLAQAN----FAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63
           A  L L+  C  Q N    F  HFFD              + EDTPVGS V  L   D +
Sbjct: 12  AWLLVLISGCWGQVNRLPFFTNHFFDT----------YLLISEDTPVGSSVTQLLAQDMD 61

Query: 64  GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVI 123
            DP+ + +S + ++R  F+V+P  G + L + LDRE + E     S+SD   ++  KV I
Sbjct: 62  NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120

Query: 124 LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAV 183
            V D ND AP F  +PY   +PE+ P G+ IF V+A D D G+GGSV Y  Q     FA+
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180

Query: 184 DRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
           D   G++ +     LDYE ++ + +TV A D            S    + + + DVQDM 
Sbjct: 181 DSARGIVTVI--RELDYETTQAYQLTVNATD-----QDKTRPLSTLANLAIIITDVQDMD 233

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAI 302
           P+F+  PY   +YE + PG+ V  + A+D D+G+P  I Y++V+GN +  F ++  SG +
Sbjct: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVL 293

Query: 303 SIT---QSPAQLQREVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPPTFYGESG 358
           ++         L    + L V+ TE++   +P+ A  T    I ++D+N++ P F     
Sbjct: 294 TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF----- 348

Query: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQ--GANAKFNLQLVGPRG-IFRVVPQTVLN 415
             + + +++ E    G  L  L I V D D+  G N+ F + LVG     F + P +V  
Sbjct: 349 NSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407

Query: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
           +A + I V  +  +D+E      F L A E + P+     A V I L++ NDN P F   
Sbjct: 408 KADIRIRV--AIPLDYETVDRYDFDLFANE-SVPDHV-GYAKVKITLINENDNRPIFSQP 463

Query: 476 YYVARIPENAPGGSSVVAV 494
            Y   + EN   G+SV+ V
Sbjct: 464 LYNISLYENVTVGTSVLTV 482



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 124/479 (25%), Positives = 196/479 (40%), Gaps = 70/479 (14%)

Query: 143 LVPEDIPAGSIIFKVHAVDRDTG------SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGA 196
           L+ ED P GS + ++ A D D        SG   + F       FAV+  +GV+ L+   
Sbjct: 41  LISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF-------FAVEPDTGVVWLRQ-- 91

Query: 197 TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
            LD E      +     D  G +         T  V + V DV D AP F   PY   + 
Sbjct: 92  PLDRETKSEFTVEFSVSDHQGVI---------TRKVNIQVGDVNDNAPTFHNQPYSVRIP 142

Query: 257 EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVY 316
           E+T  G+ +  V A D D G    +LYS    +   F I+   G +++ +       + Y
Sbjct: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAY 201

Query: 317 ELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEI 376
           +L V  T+       +  A + + I   D+ +  P F         +  ++ EH P G  
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIII--TDVQDMDPIFINLP-----YSTNIYEHSPPGTT 254

Query: 377 LRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA----QVTIIVENSAAIDFE 432
           +R   IT  D D+G           PRGI   +     N       ++ ++  +  +D E
Sbjct: 255 VR--IITAIDQDKGR----------PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302

Query: 433 KSK-----VLTFKLLAVEVN---TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
                   +LT K    E+N   TP   + T    I ++D NDN P+F+S  Y   I E 
Sbjct: 303 NPLYSHGFILTVK--GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360

Query: 485 APGGSSV-VAVTAVDPDTGPWGEVKYSTY--GTGADLFLIHPST----GLIYTQPWASLD 537
           A  G ++ + +  VD D        +  Y  G  +  F+I P++      I  +    LD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420

Query: 538 AEATARYNFYVKA-EDMEGKYSVAEVFITLLDVNDHPPQFGKSVQK----KTMVLGTPV 591
            E   RY+F + A E +      A+V ITL++ ND+ P F + +      + + +GT V
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 73/237 (30%), Positives = 106/237 (44%), Gaps = 21/237 (8%)

Query: 455 TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGT 514
           T  V IQ+ D NDN P F +  Y  RIPEN P G+ +  V A DPD G  G V YS +  
Sbjct: 115 TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS-FQP 173

Query: 515 GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK---YSVAEVFITLLDVND 571
            +  F I  + G++       LD E T  Y   V A D +      ++A + I + DV D
Sbjct: 174 PSQFFAIDSARGIVTV--IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD 231

Query: 572 HPPQFGKSVQKKTMVL-----GTPVK-IEAIDEDAEEPNNLVDYSITHAEPANVFDINSH 625
             P F  ++   T +      GT V+ I AID+D   P   + Y+I      ++F ++  
Sbjct: 232 MDPIF-INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIFALDYI 289

Query: 626 TGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTA----LLKIDITD 678
           +G + L      LD  + +      L     +  D  +PS +T      +L IDI D
Sbjct: 290 SGVLTLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 81/366 (22%), Positives = 158/366 (43%), Gaps = 45/366 (12%)

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA--FEINETSGAISITQSPA 309
           Y  + EDT  GS V +++A D D    N  L   V+G + +  F +   +G + + Q   
Sbjct: 39  YLLISEDTPVGSSVTQLLAQDMD----NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94

Query: 310 QLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNE 369
           +  +  + +   V++           T  V I++ D+N++ PTF+ +      + + + E
Sbjct: 95  RETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQP-----YSVRIPE 143

Query: 370 HPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI 429
           + P G  +    +   D D GA          P   F +     +    VT+I E    +
Sbjct: 144 NTPVGTPI--FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGI----VTVIRE----L 193

Query: 430 DFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGS 489
           D+E ++     + A + +     S+ A++ I + D  D  P F +L Y   I E++P G+
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253

Query: 490 SVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAE---ATARYN 545
           +V  +TA+D D G    + Y+   G    +F +   +G++       LD E    +  + 
Sbjct: 254 TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLN--GLLDRENPLYSHGFI 311

Query: 546 FYVKAEDMEGKYSVAEVFIT------LLDVNDHPPQFGKS------VQKKTMVLGTPVKI 593
             VK  ++    + ++  +T      ++D+ND+ P+F  S       +   +    P+ I
Sbjct: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371

Query: 594 EAIDED 599
           + +D+D
Sbjct: 372 QVVDKD 377



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 67/246 (27%), Positives = 100/246 (40%), Gaps = 31/246 (12%)

Query: 46  EDTPVGSHVYTLNGTDPE-GDP--ISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
           E +P G+ V  +   D + G P  I Y I    +T S+F++D   G +TL   LDRE   
Sbjct: 247 EHSPPGTTVRIITAIDQDKGRPRGIGYTI-VSGNTNSIFALDYISGVLTLNGLLDRENPL 305

Query: 103 EIEAIISISDGLNL----------VAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG- 151
                I    G  L          V     ILV D ND AP F    Y   + E    G 
Sbjct: 306 YSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGF 365

Query: 152 SIIFKVHAVDRDTGSGGSVTYFL----QNLH----SPFAVDRHSGVLRLQAGATLDYERS 203
           ++   +  VD+D   G +  + +     N H    SP +V   + + R++    LDYE  
Sbjct: 366 ALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADI-RIRVAIPLDYETV 424

Query: 204 RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGS 263
             +   + A +        D V  A   +T+  E+  D  P+F    Y   +YE+   G+
Sbjct: 425 DRYDFDLFANESV-----PDHVGYAKVKITLINEN--DNRPIFSQPLYNISLYENVTVGT 477

Query: 264 EVLKVV 269
            VL V+
Sbjct: 478 SVLTVL 483


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
           sapiens]
          Length = 2923

 Score =  206 bits (525), Expect = 6e-53
 Identities = 195/656 (29%), Positives = 303/656 (46%), Gaps = 57/656 (8%)

Query: 43  SLPEDTPVGSHVYTLNGTDP---EGDPISYHIS--FDPSTRSVFSVDPTFGNITLVEELD 97
           ++PE+ P G+ V +L   DP   E   + Y +   FD  +   FS+DP  G +T  EELD
Sbjct: 189 TVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELD 248

Query: 98  RE-REDEIEAIISISDGL--NLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154
           RE +   +  + +   G+        + ILVTD ND  P F Q+ Y   + E++  G  +
Sbjct: 249 RETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEV 308

Query: 155 FKVHAVDRDTGSGGSVTYFLQNLH--SP---FAVDRHSGVLRLQAGATLDYERSRTHYIT 209
             V A D D     ++ Y L      SP   F +D  SGV+R +    +D E   ++ +T
Sbjct: 309 LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRG--PVDREEVESYQLT 366

Query: 210 VVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVV 269
           V A D G R  G     S T  V ++VED  D AP F    Y   V ED  PG+ VL+V 
Sbjct: 367 VEASDQG-RDPGPR---STTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT 422

Query: 270 AMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPA 328
           A D D+G    + YS+++GN  G F ++  +GA+ +  SP   +    E  ++V      
Sbjct: 423 ASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVV-SPLDYE-TTKEYTLRVRAQDGG 480

Query: 329 GSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSD 388
             P +  +  VT++++D+N++ P F         F+ ++ E  P G ++  L +   D+D
Sbjct: 481 RPPLSNVSGLVTVQVLDINDNAPIFV-----STPFQATVLESVPLGYLV--LHVQAIDAD 533

Query: 389 QGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNT 448
            G NA+   +L G    F   P T+ N    T  +  +A +D E+    +F + A +  T
Sbjct: 534 AGDNARLEYRLAGVGHDF---PFTINNG---TGWISVAAELDREEVDFYSFGVEARDHGT 587

Query: 449 PEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
           P   +++A V + +LD NDN P F    Y  R+ E+A  G+SVV V+AVD D      + 
Sbjct: 588 P-ALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVIT 644

Query: 509 YS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLL 567
           Y  T G   + F I   +G         LD +   +Y   V A D   +   A++ + + 
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVT 703

Query: 568 DVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
           D N H P F  S     V +      T V I A DED  E N  + Y +  + P   F I
Sbjct: 704 DANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE-NARITYFMEDSIPQ--FRI 760

Query: 623 NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
           ++ TG +  +  +   D +          ++L + A+D G P  S T  L+I + D
Sbjct: 761 DADTGAVTTQAELDYEDQVS---------YTLAITARDNGIPQKSDTTYLEILVND 807



 Score =  197 bits (501), Expect = 3e-50
 Identities = 155/493 (31%), Positives = 238/493 (48%), Gaps = 41/493 (8%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGN--ITLVEELDRERE 101
            L ED  VG+ V T++  D +   +  +     +TR+ FS+    G   ++L   LD + E
Sbjct: 619  LNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678

Query: 102  DEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
             +    ++ SDG      ++V+ VTDAN   P F    Y   V ED PAG+ +  + A D
Sbjct: 679  RQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738

Query: 162  RDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHG 221
             DTG    +TYF+++    F +D  +G +  Q  A LDYE   ++ + + A+D G     
Sbjct: 739  EDTGENARITYFMEDSIPQFRIDADTGAVTTQ--AELDYEDQVSYTLAITARDNGIPQK- 795

Query: 222  ADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRI 281
                 S TT + + V DV D AP F+   Y G VYED  P + VL++ A D D G   R+
Sbjct: 796  -----SDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRV 850

Query: 282  LYSLVNGN--DGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPV 339
             Y+   G+  DG F +  TSG   I ++  +L RE    +V        G P A+  + V
Sbjct: 851  FYTFQGGDDGDGDFIVESTSG---IVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEV 907

Query: 340  TIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQL 399
            T+ ++D+N++PP F      Q+ F++ + E+ P G  L   ++T  D D+G NA+   Q+
Sbjct: 908  TVTVLDVNDNPPVF-----EQDEFDVFVEENSPIG--LAVARVTATDPDEGTNAQIMYQI 960

Query: 400  VGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVV 459
            V   G    V Q  +   ++T +V+    +D+E        + A    T     S A V 
Sbjct: 961  V--EGNIPEVFQLDIFSGELTALVD----LDYEDRPEYVLVIQA----TSAPLVSRATVH 1010

Query: 460  IQLLDTNDNVP---KFDSLY--YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYG 513
            ++LLD NDN P    F+ L+  YV     + PGG ++  V A DPD      + YS   G
Sbjct: 1011 VRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHDPDIS--DSLTYSFERG 1067

Query: 514  TGADLFLIHPSTG 526
                L L++ STG
Sbjct: 1068 NELSLVLLNASTG 1080



 Score =  188 bits (477), Expect = 2e-47
 Identities = 181/670 (27%), Positives = 289/670 (43%), Gaps = 76/670 (11%)

Query: 46   EDTPVGSHVYTLNGTDPE--GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDE 103
            ED   G+ V  +  +D +   + + ++     + R  F +D   G + +V  LD E   E
Sbjct: 410  EDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKE 469

Query: 104  IEAIISISDG----LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
                +   DG    L+ V+  V + V D ND AP F+  P+ A V E +P G ++  V A
Sbjct: 470  YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQA 529

Query: 160  VDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRL 219
            +D D G    + Y L  +   F    ++G   +   A LD E    +   V A+D     
Sbjct: 530  IDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARD----- 584

Query: 220  HGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPN 279
            HG   + +A+ +V+V V DV D  P F    Y   + ED   G+ V+ V A+  DR   +
Sbjct: 585  HGTPAL-TASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAV--DRDAHS 641

Query: 280  RILYSLVNGND-GAFEINETSGAISITQS-PAQLQREVYELHVQVTEMSPAGSPAAQATV 337
             I Y + +GN    F I   SG   ++ + P       Y+L  Q      A     Q T 
Sbjct: 642  VITYQITSGNTRNRFSITSQSGGGLVSLALPLD-----YKLERQYVLAVTASDGTRQDTA 696

Query: 338  PVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNL 397
             + + + D N H P F       + + +++NE  P G  +  + I+  D D G NA+   
Sbjct: 697  QIVVNVTDANTHRPVF-----QSSHYTVNVNEDRPAGTTV--VLISATDEDTGENARITY 749

Query: 398  QLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTAD 457
             +      FR+   T          V   A +D+E     T  + A +   P+K S T  
Sbjct: 750  FMEDSIPQFRIDADTG--------AVTTQAELDYEDQVSYTLAITARDNGIPQK-SDTTY 800

Query: 458  VVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYG--TG 515
            + I + D NDN P+F    Y   + E+ P  +SV+ ++A D D+G  G V Y+  G   G
Sbjct: 801  LEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDG 860

Query: 516  ADLFLIHPSTGLIYTQPWASLDAEATARY--NFYVKAEDMEGKYSVAEVFITLLDVNDHP 573
               F++  ++G++ T     LD E  A+Y    Y   + M    +  EV +T+LDVND+P
Sbjct: 861  DGDFIVESTSGIVRT--LRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918

Query: 574  P-----QFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGE 628
            P     +F   V++ + +     ++ A D D E  N  + Y I       VF ++  +GE
Sbjct: 919  PVFEQDEFDVFVEENSPIGLAVARVTATDPD-EGTNAQIMYQIVEGNIPEVFQLDIFSGE 977

Query: 629  IWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRSPMA 688
                     L AL            +++  +DR  P +    +L I  T A  +SR+ + 
Sbjct: 978  ---------LTAL------------VDLDYEDR--PEY----VLVIQATSAPLVSRATVH 1010

Query: 689  AFLIQTKDNP 698
              L+   DNP
Sbjct: 1011 VRLLDRNDNP 1020



 Score =  184 bits (467), Expect = 3e-46
 Identities = 159/516 (30%), Positives = 243/516 (47%), Gaps = 50/516 (9%)

Query: 132 APRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP-----FAVDRH 186
           AP+F    Y A VPE+ PAG+ +  + A+D D G  G + Y +  L        F++D  
Sbjct: 178 APQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237

Query: 187 SGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF 246
           +G   +     LD E   TH   V A+D G          SA  T+T+ V D  D  PVF
Sbjct: 238 TGA--VTTAEELDRETKSTHVFRVTAQDHGMPRR------SALATLTILVTDTNDHDPVF 289

Query: 247 VGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETSGAI 302
               Y   + E+   G EVL V A DGD      ILY L+ G+ G+    FEI+  SG I
Sbjct: 290 EQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349

Query: 303 SITQSPAQLQR-EVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQN 361
             T+ P   +  E Y+L V+ ++      P +  T  V + + D N++ P F      + 
Sbjct: 350 R-TRGPVDREEVESYQLTVEASDQGRDPGPRS-TTAAVFLSVEDDNDNAPQF-----SEK 402

Query: 362 RFELSMNEHPPQGEILRGLKITVNDSDQGANA--KFNLQLVGPRGIFRVVPQTVLNEAQV 419
           R+ + + E    G  +  L++T +D D+G+NA   +++     RG F +  QT       
Sbjct: 403 RYVVQVREDVTPGAPV--LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTG------ 454

Query: 420 TIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVA 479
              ++  + +D+E +K  T ++ A +   P   + +  V +Q+LD NDN P F S  + A
Sbjct: 455 --ALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA 512

Query: 480 RIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADL-FLIHPSTGLIYTQPWASLDA 538
            + E+ P G  V+ V A+D D G    ++Y   G G D  F I+  TG I     A LD 
Sbjct: 513 TVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVA--AELDR 570

Query: 539 EATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGK-----SVQKKTMVLGTPV 591
           E    Y+F V+A D       + A V +T+LDVND+ P F +      + +   V  + V
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630

Query: 592 KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTG 627
            + A+D DA   ++++ Y IT     N F I S +G
Sbjct: 631 TVSAVDRDA---HSVITYQITSGNTRNRFSITSQSG 663



 Score =  151 bits (381), Expect = 3e-36
 Identities = 172/663 (25%), Positives = 277/663 (41%), Gaps = 84/663 (12%)

Query: 81   FSVDPTFGNITLVEELDRERED----EIEAIISISDGLNLVAEKVVILVTDANDEAPRFI 136
            F+++   G I++  ELDRE  D     +EA    +  L   A  V + V D ND  P F 
Sbjct: 553  FTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASAS-VSVTVLDVNDNNPTFT 611

Query: 137  QEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGA 196
            Q  Y   + ED   G+ +  V AVDRD  S  +      N  + F++   SG   +    
Sbjct: 612  QPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLAL 671

Query: 197  TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
             LDY+  R + + V A DG  +          T  + VNV D     PVF  + Y   V 
Sbjct: 672  PLDYKLERQYVLAVTASDGTRQ---------DTAQIVVNVTDANTHRPVFQSSHYTVNVN 722

Query: 257  EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV- 315
            ED   G+ V+ + A D D G+  RI Y  +  +   F I+  +GA++ TQ+    + +V 
Sbjct: 723  EDRPAGTTVVLISATDEDTGENARITY-FMEDSIPQFRIDADTGAVT-TQAELDYEDQVS 780

Query: 316  YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGE 375
            Y L +   +    G P    T  + I + D+N++ P F  +S   + +E    + PP   
Sbjct: 781  YTLAITARDN---GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE----DVPPFTS 833

Query: 376  ILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI------ 429
            +L+   I+  D D G N +      G             ++     IVE+++ I      
Sbjct: 834  VLQ---ISATDRDSGLNGRVFYTFQGG------------DDGDGDFIVESTSGIVRTLRR 878

Query: 430  -DFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGG 488
             D E       +  AV+   P    +  +V + +LD NDN P F+   +   + EN+P G
Sbjct: 879  LDRENVAQYVLRAYAVDKGMPPA-RTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIG 937

Query: 489  SSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFY 547
             +V  VTA DPD G   ++ Y    G   ++F +   +G +       LD E    Y   
Sbjct: 938  LAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTAL--VDLDYEDRPEYVLV 995

Query: 548  VKAEDMEGKYSVAEVFITLLDVNDHPPQFGK---------SVQKKTMVLGTPVKIEAIDE 598
            ++A       S A V + LLD ND+PP  G          + +  +   G   ++ A D 
Sbjct: 996  IQATSAP-LVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDP 1054

Query: 599  DAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI---RSLDALHNITPGRDCLWSLE 655
            D  +    + YS       ++  +N+ TGE+ L  ++   R L+A+            + 
Sbjct: 1055 DISDS---LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAI------------MS 1099

Query: 656  VQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKD-NPMKAVGVLAGTMATVVA 714
            V   D G  S +    L++ I   E L+ S      ++ +D +P + +  L G     VA
Sbjct: 1100 VLVSD-GVHSVTAQCALRVTIITDEMLTHS----ITLRLEDMSPERFLSPLLGLFIQAVA 1154

Query: 715  ITV 717
             T+
Sbjct: 1155 ATL 1157



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 66/259 (25%), Positives = 114/259 (44%), Gaps = 29/259 (11%)

Query: 467 DNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYST----YGTGADLFLIH 522
           +  P+F    Y A +PEN P G+ V ++ A+DPD G  G ++Y+            F + 
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235

Query: 523 PSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSV 580
           P TG + T     LD E  + + F V A+D  M  + ++A + I + D NDH P F +  
Sbjct: 236 PVTGAVTTA--EELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQE 293

Query: 581 QKKTMVLGTPV-----KIEAIDEDAEEPNNLVDYSI---THAEPANVFDINSHTGEIWLK 632
            K+++     V      + A D DA  PN  + Y +   +   P+ VF+I+  +G I  +
Sbjct: 294 YKESLRENLEVGYEVLTVRATDGDA-PPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTR 352

Query: 633 NSIRSLDALHNITPGRDCLWSLEVQAKDRG---SPSFSTTALLKIDITDAETLSRSPMAA 689
             +   +            + L V+A D+G    P  +T A+      D +   +     
Sbjct: 353 GPVDREEVES---------YQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKR 403

Query: 690 FLIQTKDNPMKAVGVLAGT 708
           +++Q +++      VL  T
Sbjct: 404 YVVQVREDVTPGAPVLRVT 422


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score =  206 bits (525), Expect = 6e-53
 Identities = 188/697 (26%), Positives = 304/697 (43%), Gaps = 69/697 (9%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSV----FSVDPTFGNITLVEE 95
            +L E+   G  +  L  TD +  P   + Y     P+ R+     F +DP  G I+    
Sbjct: 441  TLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR 500

Query: 96   LDREREDEIEAIISISD-----GLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPA 150
            +DRE  +  E ++  SD     G      +V I V D ND AP+F ++ YVA V ED+  
Sbjct: 501  VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560

Query: 151  GSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 208
             +++ +V A DRD  + G V Y +   N    FA+D  +G   +Q  A LD+E  R + +
Sbjct: 561  HTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTG--EIQVVAPLDFEAEREYAL 618

Query: 209  TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268
             + A+D      G   + + T   ++ V D+ D  P+FV TP+   V E+   G  V+ +
Sbjct: 619  RIRAQDA-----GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673

Query: 269  VAMDGDRGKPNRILYSLVN-GNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSP 327
             A+D D G+  R+ YSL     D  F IN  +G +S++     L RE  E +    E   
Sbjct: 674  QAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVS---GPLDRESVEHYFFGVEARD 730

Query: 328  AGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDS 387
             GSP   A+  VT+ ++D+N++ P F         + L +NE    G  +    ++V   
Sbjct: 731  HGSPPLSASASVTVTVLDVNDNRPEF-----TMKEYHLRLNEDAAVGTSV----VSVTAV 781

Query: 388  DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
            D+ AN+  + Q+ G     R    T      VT+    +  +D+++ +     L A    
Sbjct: 782  DRDANSAISYQITGGNTRNRFAISTQGGVGLVTL----ALPLDYKQERYFKLVLTA---- 833

Query: 448  TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEV 507
            +         V I + D N + P F S +Y   + E+ P GS++V ++A D D G    +
Sbjct: 834  SDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARI 893

Query: 508  KYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFIT 565
             Y         F I   +G I  Q  A LD E    Y   + A D  +  K     V + 
Sbjct: 894  TY-LLEDNLPQFRIDADSGAITLQ--APLDYEDQVTYTLAITARDNGIPQKADTTYVEVM 950

Query: 566  LLDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPAN-V 619
            + DVND+ PQF  S     V +      + ++I A D DA   N  V Y+  + E  +  
Sbjct: 951  VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDA-HANGRVQYTFQNGEDGDGD 1009

Query: 620  FDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDA 679
            F I   +G   +  ++R LD           ++ L   A DRG P   T   +++ + D 
Sbjct: 1010 FTIEPTSG---IVRTVRRLDR------EAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDV 1060

Query: 680  -ETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAI 715
             +     P   F ++ K+N      ++   +A + A+
Sbjct: 1061 NDNAPVFPAEEFEVRVKEN-----SIVGSVVAQITAV 1092



 Score =  196 bits (498), Expect = 8e-50
 Identities = 175/575 (30%), Positives = 268/575 (46%), Gaps = 60/575 (10%)

Query: 128 ANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP-----FA 182
           A +  P+F Q  Y  LVPE+  AG+ + +V A D D G  G + Y L  L +      F+
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377

Query: 183 VDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDM 242
           +D  SG++R    A LD E    HY+ V A+D     HG+  + SATT V V V D  D 
Sbjct: 378 IDPQSGLIR--TAAALDRESMERHYLRVTAQD-----HGSPRL-SATTMVAVTVADRNDH 429

Query: 243 APVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVN------GNDGAFEIN 296
           +PVF    Y   + E+   G  +L++ A DGD      + Y  V           AFEI+
Sbjct: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489

Query: 297 ETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGE 356
             SG IS +    +   E YEL V+ ++      P + ATV V I ++D N++ P F   
Sbjct: 490 PRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRS-ATVRVHITVLDENDNAPQF--- 545

Query: 357 SGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTVL 414
              + R+   + E      ++  L++T  D D+ AN   +  ++    RG F +   ++ 
Sbjct: 546 --SEKRYVAQVREDVRPHTVV--LRVTATDRDKDANGLVHYNIISGNSRGHFAI--DSLT 599

Query: 415 NEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDS 474
            E QV       A +DFE  +    ++ A +   P   ++T    IQ++D ND++P F S
Sbjct: 600 GEIQVV------APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS 653

Query: 475 LYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADL-FLIHPSTGLIYTQPW 533
             +   + ENAP G SV+ + AVD D G    ++YS  G   D  F+I+ +TG +     
Sbjct: 654 TPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVS-- 711

Query: 534 ASLDAEATARYNFYVKAEDMEGK--YSVAEVFITLLDVNDHPPQFGKS-----VQKKTMV 586
             LD E+   Y F V+A D       + A V +T+LDVND+ P+F        + +   V
Sbjct: 712 GPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAV 771

Query: 587 LGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITP 646
             + V + A+D DA   N+ + Y IT     N F I++  G + L      LD       
Sbjct: 772 GTSVVSVTAVDRDA---NSAISYQITGGNTRNRFAISTQ-GGVGLVTLALPLDY------ 821

Query: 647 GRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAET 681
            ++  + L + A DR   +      + I+ITDA T
Sbjct: 822 KQERYFKLVLTASDR---ALHDHCYVHINITDANT 853



 Score =  177 bits (450), Expect = 3e-44
 Identities = 180/657 (27%), Positives = 284/657 (43%), Gaps = 59/657 (8%)

Query: 44  LPEDTPVGSHVYTLNGTDP---EGDPISYHISFDPSTRSV--FSVDPTFGNITLVEELDR 98
           +PE+   G+ V  +   DP   E   + Y ++   ++RS+  FS+DP  G I     LDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393

Query: 99  EREDEIEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 155
           E  +     ++  D  +        V + V D ND +P F Q  Y   + E++  G  I 
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL 453

Query: 156 KVHAVDRDTGSGGSVTYFLQN-------LHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 208
           ++ A D D     ++ Y             + F +D  SG+  +     +D E   ++ +
Sbjct: 454 QLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL--ISTSGRVDREHMESYEL 511

Query: 209 TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268
            V A D G          SAT  V + V D  D AP F    Y   V ED  P + VL+V
Sbjct: 512 VVEASDQGQEPGPR----SATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRV 567

Query: 269 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSP 327
            A D D+     + Y++++GN  G F I+  +G I +  +P   + E  E  +++     
Sbjct: 568 TATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLDFEAE-REYALRIRAQDA 625

Query: 328 AGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDS 387
              P +  T   +I++VD+N+H P F         F++S+ E+ P G  +  + I   D+
Sbjct: 626 GRPPLSNNTGLASIQVVDINDHIPIFV-----STPFQVSVLENAPLGHSV--IHIQAVDA 678

Query: 388 DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
           D G NA+    L G      V P T       T  V  S  +D E  +   F + A +  
Sbjct: 679 DHGENARLEYSLTG------VAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHG 732

Query: 448 TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEV 507
           +P   S++A V + +LD NDN P+F    Y  R+ E+A  G+SVV+VTAVD D      +
Sbjct: 733 SP-PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN--SAI 789

Query: 508 KYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITL 566
            Y  T G   + F I    G+        LD +    +   + A D    +    V I +
Sbjct: 790 SYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-RALHDHCYVHINI 848

Query: 567 LDVNDHPPQF-----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
            D N H P F       SV +   +  T V I A D+D  E N  + Y +    P   F 
Sbjct: 849 TDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGE-NARITYLLEDNLPQ--FR 905

Query: 622 INSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
           I++ +G I L+     LD    +T      ++L + A+D G P  + T  +++ + D
Sbjct: 906 IDADSGAITLQ---APLDYEDQVT------YTLAITARDNGIPQKADTTYVEVMVND 953



 Score =  169 bits (429), Expect = 8e-42
 Identities = 147/467 (31%), Positives = 221/467 (47%), Gaps = 40/467 (8%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDP-ISYHISFDPSTRSVFSVDPT--FGNITLVEELDRER 100
            L ED  VG+ V ++   D + +  ISY I+   +TR+ F++      G +TL   LD ++
Sbjct: 765  LNEDAAVGTSVVSVTAVDRDANSAISYQIT-GGNTRNRFAISTQGGVGLVTLALPLDYKQ 823

Query: 101  EDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV 160
            E   + +++ SD        V I +TDAN   P F    Y   V ED P GS I  + A 
Sbjct: 824  ERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISAS 883

Query: 161  DRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLH 220
            D D G    +TY L++    F +D  SG + LQ  A LDYE   T+ + + A+D  G   
Sbjct: 884  DDDVGENARITYLLEDNLPQFRIDADSGAITLQ--APLDYEDQVTYTLAITARD-NGIPQ 940

Query: 221  GADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNR 280
             AD     TT V V V DV D AP FV + Y G V ED  P + VL++ A D D     R
Sbjct: 941  KAD-----TTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR 995

Query: 281  ILYSLVNG--NDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVP 338
            + Y+  NG   DG F I  TSG   I ++  +L RE   ++         G P  +  V 
Sbjct: 996  VQYTFQNGEDGDGDFTIEPTSG---IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVS 1052

Query: 339  VTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQ 398
            + + + D+N++ P F     P   FE+ + E+   G ++   +IT  D D+G NA    Q
Sbjct: 1053 IQVMVQDVNDNAPVF-----PAEEFEVRVKENSIVGSVV--AQITAVDPDEGPNAHIMYQ 1105

Query: 399  LVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADV 458
            +V   G    + Q  +   ++T +++    +D+E  +    + + V   T     S A V
Sbjct: 1106 IV--EGNIPELFQMDIFSGELTALID----LDYEARQ----EYVIVVQATSAPLVSRATV 1155

Query: 459  VIQLLDTNDNVP---KFDSLY--YVARIPENAPGGSSVVAVTAVDPD 500
             ++L+D NDN P    F  L+  YV+   +  P G  +  + A DPD
Sbjct: 1156 HVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPD 1201



 Score =  152 bits (383), Expect = 2e-36
 Identities = 176/664 (26%), Positives = 270/664 (40%), Gaps = 69/664 (10%)

Query: 43   SLPEDTPVGS---HVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            S+ E+ P+G    H+  ++    E   + Y ++   +  + F ++   G +++   LDRE
Sbjct: 659  SVLENAPLGHSVIHIQAVDADHGENARLEYSLT-GVAPDTPFVINSATGWVSVSGPLDRE 717

Query: 100  REDE----IEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 155
              +     +EA    S  L+  A  V + V D ND  P F  + Y   + ED   G+ + 
Sbjct: 718  SVEHYFFGVEARDHGSPPLSASAS-VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVV 776

Query: 156  KVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDG 215
             V AVDRD  S  S      N  + FA+    GV  +     LDY++ R   + + A D 
Sbjct: 777  SVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR 836

Query: 216  GGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDR 275
                H           V +N+ D     PVF    Y   V ED   GS ++ + A D D 
Sbjct: 837  ALHDH---------CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDV 887

Query: 276  GKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV-YELHVQVTEMSPAGSPAAQ 334
            G+  RI Y L+  N   F I+  SGAI++ Q+P   + +V Y L +   +    G P   
Sbjct: 888  GENARITY-LLEDNLPQFRIDADSGAITL-QAPLDYEDQVTYTLAITARD---NGIPQKA 942

Query: 335  ATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAK 394
             T  V + + D+N++ P F       +   L   + PP   +   L+I+  D D  AN +
Sbjct: 943  DTTYVEVMVNDVNDNAPQFVA----SHYTGLVSEDAPPFTSV---LQISATDRDAHANGR 995

Query: 395  FNLQLVGPR---GIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEK 451
                        G F + P         + IV     +D E   V      AV+   P  
Sbjct: 996  VQYTFQNGEDGDGDFTIEP--------TSGIVRTVRRLDREAVSVYELTAYAVDRGVP-P 1046

Query: 452  FSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS- 510
              +   + + + D NDN P F +  +  R+ EN+  GS V  +TAVDPD GP   + Y  
Sbjct: 1047 LRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQI 1106

Query: 511  TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVN 570
              G   +LF +   +G +       LD EA   Y   V+A       S A V + L+D N
Sbjct: 1107 VEGNIPELFQMDIFSGEL--TALIDLDYEARQEYVIVVQATSAP-LVSRATVHVRLVDQN 1163

Query: 571  DHPPQFGK---------SVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
            D+ P             S +  T   G   +I A D D  +    + YS        +  
Sbjct: 1164 DNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDH---LFYSFERGNELQLLV 1220

Query: 622  INSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAET 681
            +N  +GE+ L    R LD        R  + S+ V   D G  S +   +L++ I   E 
Sbjct: 1221 VNQTSGELRLS---RKLD------NNRPLVASMLVTVTD-GLHSVTAQCVLRVVIITEEL 1270

Query: 682  LSRS 685
            L+ S
Sbjct: 1271 LANS 1274


>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
          Length = 1237

 Score =  195 bits (495), Expect = 2e-49
 Identities = 204/743 (27%), Positives = 334/743 (44%), Gaps = 102/743 (13%)

Query: 43  SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSV------DPTFGNITLV 93
           ++PE+T +GS       +D +  P    SY +   P  + +F +      +     + ++
Sbjct: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235

Query: 94  EELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQEPYVALVPEDIPA 150
             LDRER D  +  I + DG +       +L   V D ND AP+F +  Y A + E+ P 
Sbjct: 236 GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPI 295

Query: 151 GSIIFKVHAVDRDTGSGGSVTYFLQN----LHSPFAVDRHSGVLRLQAGATLDYERSRTH 206
           G  + +V A D D G+   + Y        +     +DR++G++ +Q    +D E   T 
Sbjct: 296 GHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG--PVDREDLSTL 353

Query: 207 YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF----VGTPYY----GYVYED 258
             +V+AKD G          SA   V V V+D+ D AP      +G   +      + ED
Sbjct: 354 RFSVLAKDRGTNPK------SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISED 407

Query: 259 TLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQ------ 312
               + V  V   D D G+ N  +  +V G D  F++ + S   S ++    LQ      
Sbjct: 408 VAEETAVALVQVSDRDEGE-NAAVTCVVAG-DVPFQLRQASETGSDSKKKYFLQTTTPLD 465

Query: 313 -REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
             +V +  +++  +  +G+P   +T  + +++VD+N++ P F      Q+  E++  E+ 
Sbjct: 466 YEKVKDYTIEIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVF-----TQSVTEVAFPENN 519

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLV---GPRGIFRVVPQTVLNEAQVTIIVENSAA 428
             GE++   +IT +D+D G+NA+    L      +G+F + P+T   E QV        +
Sbjct: 520 KPGEVIA--EITASDADSGSNAELVYSLEPEPAAKGLFTISPET--GEIQV------KTS 569

Query: 429 IDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGG 488
           +D E+ +    K++A +  +P     TA V++ +LD NDN PKF    Y   + EN P  
Sbjct: 570 LDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628

Query: 489 SSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYV 548
           S V  VT +D D G   +V+ S      D F+I   TG I +    S D E  + Y F +
Sbjct: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSS--LSFDREQQSTYTFQL 685

Query: 549 KAED--MEGKYSVAEVFITLLDVNDHPPQFG-------KSVQKKTMVLGTPVKIEAIDED 599
           KA D  +  + +   V I +LD ND+ P          K +  +T +  T  ++ A D D
Sbjct: 686 KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD 745

Query: 600 AEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI-RSLDALHNITPGRDCLWSLEVQA 658
           +     L+ YSI    P  +F I SH+G I L+  I R    LH           L V+ 
Sbjct: 746 SGVNAELI-YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHR----------LVVKV 794

Query: 659 KDRGSPSFSTTALLKIDITDAETL-SRSPMAAFLIQTKDNPM--------------KAVG 703
            DRG P    TAL+ + +   ETL +R+ +   L  + D P+              +   
Sbjct: 795 SDRGKPPRYGTALVHLYVN--ETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGN 852

Query: 704 VLAGTMATVVAITVLISTATFWR 726
           +L G +A VVA+ +LI+ A   R
Sbjct: 853 ILFGVVAGVVAVALLIALAVLVR 875



 Score =  142 bits (358), Expect = 1e-33
 Identities = 164/656 (25%), Positives = 267/656 (40%), Gaps = 58/656 (8%)

Query: 49  PVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDE--IEA 106
           P   H+Y L    P       ++  D  T  +F+ + +     L E  ++   D   +E 
Sbjct: 84  PDVGHLYKLEVGAP-------YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEF 136

Query: 107 IISISDGLNLVAEKVV---ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRD 163
            +SI+D +   + +++   I V D ND  P F        +PE+   GS+     A DRD
Sbjct: 137 EVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 164 TGSGGSVTYFLQN-------LHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            G  G  +Y LQ             A D+     +L     LD ER  ++ +T+  +DGG
Sbjct: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                +  +   T      V D  D AP F    Y   + E++  G  V++V A D D+G
Sbjct: 257 SPPRASSALLRVT------VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQG 310

Query: 277 KPNRILYSLVNGNDGA---FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP-A 332
               I Y+     +       ++  +G I++ Q P   + ++  L   V       +P +
Sbjct: 311 ANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QGPVD-REDLSTLRFSVLAKDRGTNPKS 368

Query: 333 AQATVPVTIRIVDLNNHPPTFYGES-GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGA 391
           A+A V VT++  D+N++ PT      G     +   N      E      + V+D D+G 
Sbjct: 369 ARAQVVVTVK--DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE 426

Query: 392 NAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEK 451
           NA     + G             ++++    ++ +  +D+EK K  T +++AV+   P  
Sbjct: 427 NAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP- 485

Query: 452 FSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYST 511
            SST  + +Q++D NDN P F         PEN   G  +  +TA D D+G   E+ YS 
Sbjct: 486 LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545

Query: 512 YGTGA--DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLL 567
               A   LF I P TG I  Q   SLD E    Y   V A D         A V + +L
Sbjct: 546 EPEPAAKGLFTISPETGEI--QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVL 603

Query: 568 DVNDHPPQF-----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
           D ND+ P+F       SV +    L     +  ID D  E N  V  S           +
Sbjct: 604 DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGE-NAQVQLS-----------V 651

Query: 623 NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
               G+  ++N   ++ +  +    +   ++ +++A D G P  S    + I++ D
Sbjct: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707


>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
          Length = 1060

 Score =  195 bits (495), Expect = 2e-49
 Identities = 204/743 (27%), Positives = 334/743 (44%), Gaps = 102/743 (13%)

Query: 43  SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSV------DPTFGNITLV 93
           ++PE+T +GS       +D +  P    SY +   P  + +F +      +     + ++
Sbjct: 176 AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVM 235

Query: 94  EELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQEPYVALVPEDIPA 150
             LDRER D  +  I + DG +       +L   V D ND AP+F +  Y A + E+ P 
Sbjct: 236 GNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPI 295

Query: 151 GSIIFKVHAVDRDTGSGGSVTYFLQN----LHSPFAVDRHSGVLRLQAGATLDYERSRTH 206
           G  + +V A D D G+   + Y        +     +DR++G++ +Q    +D E   T 
Sbjct: 296 GHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG--PVDREDLSTL 353

Query: 207 YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF----VGTPYY----GYVYED 258
             +V+AKD G          SA   V V V+D+ D AP      +G   +      + ED
Sbjct: 354 RFSVLAKDRGTNPK------SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISED 407

Query: 259 TLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQ------ 312
               + V  V   D D G+ N  +  +V G D  F++ + S   S ++    LQ      
Sbjct: 408 VAEETAVALVQVSDRDEGE-NAAVTCVVAG-DVPFQLRQASETGSDSKKKYFLQTTTPLD 465

Query: 313 -REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
             +V +  +++  +  +G+P   +T  + +++VD+N++ P F      Q+  E++  E+ 
Sbjct: 466 YEKVKDYTIEIVAVD-SGNPPLSSTNSLKVQVVDVNDNAPVF-----TQSVTEVAFPENN 519

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLV---GPRGIFRVVPQTVLNEAQVTIIVENSAA 428
             GE++   +IT +D+D G+NA+    L      +G+F + P+T   E QV        +
Sbjct: 520 KPGEVIA--EITASDADSGSNAELVYSLEPEPAAKGLFTISPET--GEIQV------KTS 569

Query: 429 IDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGG 488
           +D E+ +    K++A +  +P     TA V++ +LD NDN PKF    Y   + EN P  
Sbjct: 570 LDREQRESYELKVVAADRGSPS-LQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPAL 628

Query: 489 SSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYV 548
           S V  VT +D D G   +V+ S      D F+I   TG I +    S D E  + Y F +
Sbjct: 629 SPVGMVTVIDGDKGENAQVQLSVEQDNGD-FVIQNGTGTILSS--LSFDREQQSTYTFQL 685

Query: 549 KAED--MEGKYSVAEVFITLLDVNDHPPQFG-------KSVQKKTMVLGTPVKIEAIDED 599
           KA D  +  + +   V I +LD ND+ P          K +  +T +  T  ++ A D D
Sbjct: 686 KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFD 745

Query: 600 AEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI-RSLDALHNITPGRDCLWSLEVQA 658
           +     L+ YSI    P  +F I SH+G I L+  I R    LH           L V+ 
Sbjct: 746 SGVNAELI-YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHR----------LVVKV 794

Query: 659 KDRGSPSFSTTALLKIDITDAETL-SRSPMAAFLIQTKDNPM--------------KAVG 703
            DRG P    TAL+ + +   ETL +R+ +   L  + D P+              +   
Sbjct: 795 SDRGKPPRYGTALVHLYVN--ETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGN 852

Query: 704 VLAGTMATVVAITVLISTATFWR 726
           +L G +A VVA+ +LI+ A   R
Sbjct: 853 ILFGVVAGVVAVALLIALAVLVR 875



 Score =  142 bits (358), Expect = 1e-33
 Identities = 164/656 (25%), Positives = 267/656 (40%), Gaps = 58/656 (8%)

Query: 49  PVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDE--IEA 106
           P   H+Y L    P       ++  D  T  +F+ + +     L E  ++   D   +E 
Sbjct: 84  PDVGHLYKLEVGAP-------YLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEF 136

Query: 107 IISISDGLNLVAEKVV---ILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRD 163
            +SI+D +   + +++   I V D ND  P F        +PE+   GS+     A DRD
Sbjct: 137 EVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196

Query: 164 TGSGGSVTYFLQN-------LHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
            G  G  +Y LQ             A D+     +L     LD ER  ++ +T+  +DGG
Sbjct: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGG 256

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                +  +   T      V D  D AP F    Y   + E++  G  V++V A D D+G
Sbjct: 257 SPPRASSALLRVT------VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQG 310

Query: 277 KPNRILYSLVNGNDGA---FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP-A 332
               I Y+     +       ++  +G I++ Q P   + ++  L   V       +P +
Sbjct: 311 ANAEIEYTFHQAPEVVRRLLRLDRNTGLITV-QGPVD-REDLSTLRFSVLAKDRGTNPKS 368

Query: 333 AQATVPVTIRIVDLNNHPPTFYGES-GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGA 391
           A+A V VT++  D+N++ PT      G     +   N      E      + V+D D+G 
Sbjct: 369 ARAQVVVTVK--DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGE 426

Query: 392 NAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEK 451
           NA     + G             ++++    ++ +  +D+EK K  T +++AV+   P  
Sbjct: 427 NAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPP- 485

Query: 452 FSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYST 511
            SST  + +Q++D NDN P F         PEN   G  +  +TA D D+G   E+ YS 
Sbjct: 486 LSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSL 545

Query: 512 YGTGA--DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLL 567
               A   LF I P TG I  Q   SLD E    Y   V A D         A V + +L
Sbjct: 546 EPEPAAKGLFTISPETGEI--QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVL 603

Query: 568 DVNDHPPQF-----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
           D ND+ P+F       SV +    L     +  ID D  E N  V  S           +
Sbjct: 604 DCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGE-NAQVQLS-----------V 651

Query: 623 NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
               G+  ++N   ++ +  +    +   ++ +++A D G P  S    + I++ D
Sbjct: 652 EQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLD 707


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
           sapiens]
          Length = 3014

 Score =  194 bits (494), Expect = 2e-49
 Identities = 184/678 (27%), Positives = 314/678 (46%), Gaps = 79/678 (11%)

Query: 46  EDTPVGSHVYTLNGTDPEGDPISYHISFDP--STRSVFSVDPTFGNITLVEELDREREDE 103
           E+  VG  V T+  +D +  PI+ ++ +        VF ++ + G ++    LDRE   E
Sbjct: 364 ENLEVGYEVLTIRASDRDS-PINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAE 422

Query: 104 IEAIISISD-----GLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVH 158
            + ++  +D     G       V I V D ND  P+F ++ YV  VPED+   + + +V 
Sbjct: 423 YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ 482

Query: 159 AVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
           A DRD G   ++ Y +   N+   F +   SG+  L     LD+E  + + +++ A+DG 
Sbjct: 483 ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGI--LDVINPLDFEDVQKYSLSIKAQDG- 539

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
               G   + +++  V+V V DV D  P+FV +P+   V E+   G  V+ + A+D D G
Sbjct: 540 ----GRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSG 595

Query: 277 KPNRILYSLVN--------GNDG----------AFEINETSGAISITQSPAQLQREVYEL 318
           +  R+ Y LV+        G+ G           F+I+ +SG I++    A+L RE  E 
Sbjct: 596 ENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC---AELDREEVEH 652

Query: 319 HVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILR 378
           +    E    GSP   ++  V+I ++D+N++ P F      Q  +EL +NE    G  + 
Sbjct: 653 YSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF-----TQPTYELRLNEDAAVGSSV- 706

Query: 379 GLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLT 438
              +T+   D+ AN+    QL G     R    +      +T+    +  +D+++ +   
Sbjct: 707 ---LTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITL----ALPLDYKQEQQY- 758

Query: 439 FKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVD 498
             +LAV  +   + S TA V+I + D N + P F S +Y   + E+ P G+S+  ++A D
Sbjct: 759 --VLAVTASDGTR-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSAND 815

Query: 499 PDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGK 556
            DTG    + Y         F I P +G +YT     LD E    Y   + A+D  +  K
Sbjct: 816 EDTGENARITY-VIQDPVPQFRIDPDSGTMYTM--MELDYENQVAYTLTIMAQDNGIPQK 872

Query: 557 YSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDYSI 611
                + I +LD ND+ PQF     + ++    P     +++ A D D+  PN  + Y+ 
Sbjct: 873 SDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS-GPNGRLLYTF 931

Query: 612 THAEPAN-VFDINSHTGEIWLKNSI-RSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTT 669
              +  +  F I   +G I  +  + R   A++N       LW+L V   DRGSP+   +
Sbjct: 932 QGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN-------LWALAV---DRGSPT-PLS 980

Query: 670 ALLKIDITDAETLSRSPM 687
           A ++I +T  +    +PM
Sbjct: 981 ASVEIQVTILDINDNAPM 998



 Score =  192 bits (487), Expect = 1e-48
 Identities = 192/693 (27%), Positives = 294/693 (42%), Gaps = 100/693 (14%)

Query: 44   LPEDTPVGSHVYTLNGTD-PEGDPISYHISF-DPSTRSVFSVDPTFGNITLVEELDRERE 101
            +PED  + + V  +  TD  +G   + H S    +    F +    G + ++  LD E  
Sbjct: 468  VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDV 527

Query: 102  DEIEAIISISDG----LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
             +    I   DG    L   +  V + V D ND  P F+  P+ A V E++P G  +  +
Sbjct: 528  QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHI 587

Query: 158  HAVDRDTGSGGSVTYFLQNLHS-------------------PFAVDRHSGVLRLQAGATL 198
             AVD D+G    + Y L +  S                   PF +   SG + + A   L
Sbjct: 588  QAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCA--EL 645

Query: 199  DYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYED 258
            D E    +   V A D     HG+  + S++T+V++ V DV D  PVF    Y   + ED
Sbjct: 646  DREEVEHYSFGVEAVD-----HGSPPM-SSSTSVSITVLDVNDNDPVFTQPTYELRLNED 699

Query: 259  TLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDG---AFEINETSGAISITQSPAQLQREV 315
               GS VL + A D D      I Y L  GN     A       G I++       Q + 
Sbjct: 700  AAVGSSVLTLQARDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ 757

Query: 316  YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGE 375
            Y L V       A       T  V I + D N H P F       + + +S++E  P G 
Sbjct: 758  YVLAVT------ASDGTRSHTAHVLINVTDANTHRPVFQS-----SHYTVSVSEDRPVGT 806

Query: 376  ILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSK 435
             +  L  + ND D G NA+    +  P   FR+ P +      +  ++E    +D+E   
Sbjct: 807  SIATL--SANDEDTGENARITYVIQDPVPQFRIDPDS----GTMYTMME----LDYENQV 856

Query: 436  VLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVT 495
              T  ++A +   P+K S T  + I +LD NDN P+F   +Y   I E+AP  +S++ V+
Sbjct: 857  AYTLTIMAQDNGIPQK-SDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVS 915

Query: 496  AVDPDTGPWGEVKYSTYG--TGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM 553
            A D D+GP G + Y+  G   G   F I P++G+I TQ    LD E  A YN +  A D 
Sbjct: 916  ATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ--RRLDRENVAVYNLWALAVDR 973

Query: 554  EGKYSVA---EVFITLLDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNN 605
                 ++   E+ +T+LD+ND+ P F K      V++   V     KI A D D E PN 
Sbjct: 974  GSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPD-EGPNA 1032

Query: 606  LVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPS 665
             + Y I   +  + F ++   G++    ++  LD               EV+ +      
Sbjct: 1033 QIMYQIVEGDMRHFFQLDLLNGDL---RAMVELD--------------FEVRRE------ 1069

Query: 666  FSTTALLKIDITDAETLSRSPMAAFLIQTKDNP 698
                 +L +  T A  +SR+ +   L+   DNP
Sbjct: 1070 ----YVLVVQATSAPLVSRATVHILLVDQNDNP 1098



 Score =  184 bits (466), Expect = 4e-46
 Identities = 160/497 (32%), Positives = 234/497 (47%), Gaps = 48/497 (9%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGN--ITLVEELDRERE 101
            L ED  VGS V TL   D + + +  +     +TR+ F++    G   ITL   LD ++E
Sbjct: 696  LNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQE 755

Query: 102  DEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
             +    ++ SDG       V+I VTDAN   P F    Y   V ED P G+ I  + A D
Sbjct: 756  QQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSAND 815

Query: 162  RDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHG 221
             DTG    +TY +Q+    F +D  SG +       LDYE    + +T++A+D G     
Sbjct: 816  EDTGENARITYVIQDPVPQFRIDPDSGTMYTM--MELDYENQVAYTLTIMAQDNGIPQK- 872

Query: 222  ADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRI 281
                 S TTT+ + + D  D AP F+   Y G ++ED  P + +L+V A D D G   R+
Sbjct: 873  -----SDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRL 927

Query: 282  LYSLVNGN--DGAFEINETSGAISITQSPAQLQRE---VYELHVQVTEMSPAGSPA-AQA 335
            LY+   G+  DG F I  TSG I   ++  +L RE   VY L     +    GSP    A
Sbjct: 928  LYTFQGGDDGDGDFYIEPTSGVI---RTQRRLDRENVAVYNLWALAVD---RGSPTPLSA 981

Query: 336  TVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKF 395
            +V + + I+D+N++ P F      ++  EL + E+ P G ++   KI  ND D+G NA+ 
Sbjct: 982  SVEIQVTILDINDNAPMF-----EKDELELFVEENNPVGSVV--AKIRANDPDEGPNAQI 1034

Query: 396  NLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSST 455
              Q+V   G  R   Q  L    +  +VE    +DFE  +    + + V   T     S 
Sbjct: 1035 MYQIV--EGDMRHFFQLDLLNGDLRAMVE----LDFEVRR----EYVLVVQATSAPLVSR 1084

Query: 456  ADVVIQLLDTNDN---VPKFDSLY--YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS 510
            A V I L+D NDN   +P F  L+  YV     + P G  +  + A DPD      + Y+
Sbjct: 1085 ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVS--DSLNYT 1141

Query: 511  -TYGTGADLFLIHPSTG 526
               G    L L+ P+TG
Sbjct: 1142 FVQGNELRLLLLDPATG 1158



 Score =  178 bits (451), Expect = 2e-44
 Identities = 192/675 (28%), Positives = 306/675 (45%), Gaps = 69/675 (10%)

Query: 36  NGNMALFSLPEDTPVGSHV------YTLNGTDPEGDPISYHIS--FDPSTRSVFSVDPTF 87
           N  +ALF   E+ P G+ +      YT+ G   E + +SY++   FD  +R  F +D   
Sbjct: 249 NYQVALF---ENEPAGTLILQLHAHYTIEG---EEERVSYYMEGLFDERSRGYFRIDSAT 302

Query: 88  GNITLVEELDRERED----EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVAL 143
           G ++    LDRE ++     ++A+   S         + +LV D ND +P F Q  Y   
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAV-DYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361

Query: 144 VPEDIPAGSIIFKVHAVDRDTGSGGSVTY-FLQNLHSPFAVDRHSGVLRLQAGATLDYER 202
           V E++  G  +  + A DRD+    ++ Y  L      F ++  SGV+  +  A LD E 
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTR--AVLDREE 419

Query: 203 SRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPG 262
           +  + + V A D  GR  G     SAT TV + VED  D  P F    Y   V ED    
Sbjct: 420 AAEYQLLVEAND-QGRNPGP---LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475

Query: 263 SEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQ 321
           + VL+V A D D+G+   I YS+++GN  G F ++  SG + +  +P   + +V +  + 
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVI-NPLDFE-DVQKYSLS 533

Query: 322 VTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLK 381
           +        P   ++  V+++++D+N++ P F   S P   F+ ++ E+ P G  +  + 
Sbjct: 534 IKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV--SSP---FQATVLENVPLGYPV--VH 586

Query: 382 ITVNDSDQGANAKFNLQLVGPRGIF----RVVPQTVLNEAQVTIIVENS-------AAID 430
           I   D+D G NA+ + +LV     F       P+           + NS       A +D
Sbjct: 587 IQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELD 646

Query: 431 FEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSS 490
            E+ +  +F + AV+  +P   SST+ V I +LD NDN P F    Y  R+ E+A  GSS
Sbjct: 647 REEVEHYSFGVEAVDHGSPPMSSSTS-VSITVLDVNDNDPVFTQPTYELRLNEDAAVGSS 705

Query: 491 VVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVK 549
           V+ + A D D      + Y  T G   + F +    G         LD +   +Y   V 
Sbjct: 706 VLTLQARDRDAN--SVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT 763

Query: 550 AEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPV-----KIEAIDEDAEEPN 604
           A D    ++ A V I + D N H P F  S    ++    PV      + A DED  E N
Sbjct: 764 ASDGTRSHT-AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGE-N 821

Query: 605 NLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSP 664
             + Y I   +P   F I+  +G ++   ++  LD  + +       ++L + A+D G P
Sbjct: 822 ARITYVI--QDPVPQFRIDPDSGTMY---TMMELDYENQVA------YTLTIMAQDNGIP 870

Query: 665 SFSTTALLKIDITDA 679
             S T  L+I I DA
Sbjct: 871 QKSDTTTLEILILDA 885



 Score =  156 bits (395), Expect = 7e-38
 Identities = 148/524 (28%), Positives = 230/524 (43%), Gaps = 57/524 (10%)

Query: 134 RFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP-----FAVDRHSG 188
           +F    Y   + E+ PAG++I ++HA     G    V+Y+++ L        F +D  +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303

Query: 189 VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVG 248
            +     + LD E   TH + V A D            SATT +TV V+D  D +PVF  
Sbjct: 304 AV--STDSVLDRETKETHVLRVKAVDYSTPPR------SATTYITVLVKDTNDHSPVFEQ 355

Query: 249 TPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSP 308
           + Y   V E+   G EVL + A D D      + Y ++ G    F++NE+SG +S     
Sbjct: 356 SEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVL 415

Query: 309 AQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMN 368
            + +   Y+L V+  +      P + AT  V I + D N++ P F      +  + + + 
Sbjct: 416 DREEAAEYQLLVEANDQGRNPGPLS-ATATVYIEVEDENDNYPQF-----SEQNYVVQVP 469

Query: 369 EHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAA 428
           E    G     L++   D DQG NA  +  ++       V  Q  L+     + V N   
Sbjct: 470 E--DVGLNTAVLRVQATDRDQGQNAAIHYSILSG----NVAGQFYLHSLSGILDVIN--P 521

Query: 429 IDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGG 488
           +DFE  +  +  + A +   P   +S+  V +Q+LD NDN P F S  + A + EN P G
Sbjct: 522 LDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLG 581

Query: 489 SSVVAVTAVDPDTGPWGEVKYSTYGTGADL------------------FLIHPSTGLIYT 530
             VV + AVD D+G    + Y    T +                    F IH S+G I  
Sbjct: 582 YPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITV 641

Query: 531 QPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGK-----SVQKK 583
              A LD E    Y+F V+A D       S   V IT+LDVND+ P F +      + + 
Sbjct: 642 --CAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNED 699

Query: 584 TMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTG 627
             V  + + ++A D DA   N+++ Y +T     N F ++S  G
Sbjct: 700 AAVGSSVLTLQARDRDA---NSVITYQLTGGNTRNRFALSSQRG 740



 Score =  156 bits (394), Expect = 9e-38
 Identities = 168/631 (26%), Positives = 257/631 (40%), Gaps = 68/631 (10%)

Query: 75   PSTRSVFSVDPTFGNITLVEELDREREDE----IEAIISISDGLNLVAEKVVILVTDAND 130
            P+    F +  + G IT+  ELDRE  +     +EA+   S  ++  +  V I V D ND
Sbjct: 624  PTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS-STSVSITVLDVND 682

Query: 131  EAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSG 188
              P F Q  Y   + ED   GS +  + A DRD  S   +TY L   N  + FA+    G
Sbjct: 683  NDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS--VITYQLTGGNTRNRFALSSQRG 740

Query: 189  VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVG 248
               +     LDY++ + + + V A DG           S T  V +NV D     PVF  
Sbjct: 741  GGLITLALPLDYKQEQQYVLAVTASDG---------TRSHTAHVLINVTDANTHRPVFQS 791

Query: 249  TPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSP 308
            + Y   V ED   G+ +  + A D D G+  RI Y ++      F I+  SG +      
Sbjct: 792  SHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 850

Query: 309  AQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMN 368
                +  Y L +   +    G P    T  + I I+D N++ P F  +    + FE    
Sbjct: 851  DYENQVAYTLTIMAQDN---GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFE---- 903

Query: 369  EHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPR---GIFRVVPQTVLNEAQVTIIVEN 425
            + PP   IL+   ++  D D G N +      G     G F + P +         ++  
Sbjct: 904  DAPPSTSILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSG--------VIRT 952

Query: 426  SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENA 485
               +D E   V     LAV+  +P   S++ ++ + +LD NDN P F+       + EN 
Sbjct: 953  QRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENN 1012

Query: 486  PGGSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P GS V  + A DPD GP  ++ Y    G     F +    G +  +    LD E    Y
Sbjct: 1013 PVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDL--RAMVELDFEVRREY 1070

Query: 545  NFYVKAEDMEGKYSVAEVFITLLDVNDHPP-------QFGKSVQKKTMVLGTPVKIEAID 597
               V+A       S A V I L+D ND+PP        F   V  K+    T V I  I 
Sbjct: 1071 VLVVQATSAP-LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGV-IGCIP 1128

Query: 598  EDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI---RSLDALHNITPGRDCLWSL 654
                + ++ ++Y+        +  ++  TGE+ L   +   R L+AL            +
Sbjct: 1129 AHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL------------M 1176

Query: 655  EVQAKDRGSPSFSTTALLKIDITDAETLSRS 685
            EV   D G  S +    L++ I   + L+ S
Sbjct: 1177 EVSVSD-GIHSVTAFCTLRVTIITDDMLTNS 1206


>gi|16933557 dachsous 1 precursor [Homo sapiens]
          Length = 3298

 Score =  191 bits (484), Expect = 3e-48
 Identities = 200/751 (26%), Positives = 330/751 (43%), Gaps = 87/751 (11%)

Query: 46   EDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIE 105
            ED  +GS +  + G D +  P+ +++      +  FSV    G ++L   LD E+ D  +
Sbjct: 2287 EDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQ 2346

Query: 106  AIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTG 165
              +   DG +     + +LV D ND AP F Q  Y  ++ E  P GS I  V A DRD+G
Sbjct: 2347 LQLLAHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSG 2406

Query: 166  SGGSVTYFLQNLHSPFAVDRHSGVLRLQAG-ATLDYERSRTHYITVVAKDGGGRLHGADV 224
            + G ++Y L +    F+VD ++G L    G   L ++ S    + + A+D     HGA  
Sbjct: 2407 ANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARD-----HGAP- 2460

Query: 225  VFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRIL-Y 283
              +A  TV V ++D  D AP F  + Y   V ED  PGS +L + A D D  + +  + Y
Sbjct: 2461 GRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDY 2520

Query: 284  SLVNGNDGAF--------EINETSG----AISITQSPAQLQREVYELHVQVTEMSPAGSP 331
            S+++GN G          E  E++G    A+        L  E    +      +  G P
Sbjct: 2521 SIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQP 2580

Query: 332  AAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGA 391
               + VPVT+ ++D+N++PP F   S     + +++ E  P G  L  L +  +D+D G 
Sbjct: 2581 PQSSVVPVTVTVLDVNDNPPVFTRAS-----YRVTVPEDTPVGAEL--LHVEASDADPGP 2633

Query: 392  N--AKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
            +   +F +    P G+F       L+E+  T+ + +  A+D E       +L+    +  
Sbjct: 2634 HGLVRFTVSSGDPSGLFE------LDESSGTLRLAH--ALDCETQ--ARHQLVVQAADPA 2683

Query: 450  EKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKY 509
                + A V I++ D ND+ P F        + EN P G+ V  + A+D D G +G ++Y
Sbjct: 2684 GAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRY 2743

Query: 510  STYGT-----GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFI 564
            S         G + F ++ STG +  +     D E T  +   V A D  G  S +    
Sbjct: 2744 SLLEAGPGPEGREAFALNSSTGELRAR--VPFDYEHTESFRLLVGAAD-AGNLSASVTVS 2800

Query: 565  TLLDVNDH------PPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPAN 618
             L+   D        P F   V +      +   ++A DED    + LV YS+  + P  
Sbjct: 2801 VLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDG-GADGLVLYSLATSSP-- 2857

Query: 619  VFDINSHTGEIWLKNSIRSLDALHNITPG-----RDCLWSLEVQAKDRG--SPSFSTTAL 671
             F IN  TG ++L+   R+  +    + G     R+    L ++   RG    S S T  
Sbjct: 2858 YFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRSATVP 2917

Query: 672  LKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVV--AITVLISTATFWRNKK 729
            + +DIT    L  +P         D  +  VG +A ++  VV  A+  L+      R++K
Sbjct: 2918 VTVDITHT-ALGLAP---------DLNLLLVGAVAASLGVVVVLALAALVLGLVRARSRK 2967

Query: 730  S-------NKVLP-----MRRVLRKRPSPAP 748
            +       ++  P     ++++ R+ PSP P
Sbjct: 2968 AEAAPGPMSQAAPLASDSLQKLGREPPSPPP 2998



 Score =  185 bits (470), Expect = 1e-46
 Identities = 182/618 (29%), Positives = 277/618 (44%), Gaps = 62/618 (10%)

Query: 44  LPEDTPVGSHVYTLNGTDPEGD--PISYHISFDPSTR--SVFSVDPTFGNITLVEELDRE 99
           + E+ P G+ +  ++   P G   P+ Y IS    +   +  ++D   G +     LDRE
Sbjct: 51  IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDRE 110

Query: 100 REDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
           + D         DG  +   +V + V D ND AP F Q      VPE    G+      A
Sbjct: 111 QRDRYRFTAVTPDGATV---EVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPA 167

Query: 160 VDRDTGSGGSVTYFL--QNLHSPFAVDRHSG-----VLRLQAGATLDYERSRTHY-ITVV 211
            D D G  G+  Y L        F ++   G     V  L     LD E +R+HY + + 
Sbjct: 168 RDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRE-NRSHYMLQLE 226

Query: 212 AKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAM 271
           A DGG     A  +   T      + D+ D AP F  + Y+  V E   PGS VL+V A 
Sbjct: 227 AYDGGSPPRRAQALLDVT------LLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFAS 280

Query: 272 DGDRGKPNRILYSL---VNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPA 328
           D D G    + Y +    +  DG F I+  +G + + +     QR V+EL VQ  +    
Sbjct: 281 DADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARD---G 337

Query: 329 GSPAAQATVPVTIRIVDLNNHPPT-----FYGESGPQNRFELSMNEHPPQGEILRGLKIT 383
           G+     +  VT+ + D N++ P+        +  PQ      ++E  P G+++   +I+
Sbjct: 338 GAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQ------VSEAAPPGQLV--ARIS 389

Query: 384 VNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
           V+D D G  A  N+ L G  G F +  Q       V  +V  +  +D E+      ++ A
Sbjct: 390 VSDPDDGDFAHVNVSLEGGEGHFALSTQD-----SVIYLVCVARRLDREERDAYNLRVTA 444

Query: 444 VEVNTPEKFSSTADVVIQLLDTNDNVPKFD-SLYYVARIPENAPGGSSVVAVTAVDPDTG 502
            +  +P    + A  V+ + D NDN P FD  LY    +PE A  GS VV VTA DPD G
Sbjct: 445 TDSGSP-PLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQG 503

Query: 503 PWGEVKYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSV 559
             G+V YS   G     F I P++G+I T   ASLD E   +    V A D  +    S 
Sbjct: 504 TNGQVTYSLAPGAHTHWFSIDPTSGIITTA--ASLDYELEPQPQLIVVATDGGLPPLASS 561

Query: 560 AEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDYSI--- 611
           A V + L DVND+ PQF ++    ++  GT      +++ A D D+  P  L+ YS+   
Sbjct: 562 ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADS-GPFGLLSYSLGAG 620

Query: 612 THAEPANVFDINSHTGEI 629
             +  +  F I++H+G++
Sbjct: 621 LGSSGSPPFRIDAHSGDV 638



 Score =  181 bits (458), Expect = 3e-45
 Identities = 167/613 (27%), Positives = 270/613 (44%), Gaps = 65/613 (10%)

Query: 90  ITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQEPYVALVPE 146
           + +  ELDRE        +   DG +       +L   + D ND AP F Q  Y A+V E
Sbjct: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266

Query: 147 DIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHS----PFAVDRHSGVLRLQAGATLDYER 202
            +  GS + +V A D D G  G+VTY +    S    PF++D H+G+L+L+    LD+E+
Sbjct: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLER--PLDFEQ 324

Query: 203 SRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAP----VFVGTPYYGYVYED 258
            R H + V A+DGG            +  VTV+V D  D  P    +F+       V E 
Sbjct: 325 RRVHELVVQARDGGAHPE------LGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEA 378

Query: 259 TLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQRE---V 315
             PG  V ++   D D G    +  SL  G +G F ++     I +     +L RE    
Sbjct: 379 APPGQLVARISVSDPDDGDFAHVNVSL-EGGEGHFALSTQDSVIYLVCVARRLDREERDA 437

Query: 316 YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-GPQNRFELSMNEHPPQG 374
           Y L V  T+   +GSP  +A     + + D+N++ P F  +   P+   E+++    P  
Sbjct: 438 YNLRVTATD---SGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVAL----PGS 490

Query: 375 EILRGLKITVNDSDQGANAKFNLQLVGPRGI--FRVVPQTVLNEAQVTIIVENSAAIDFE 432
            ++R   +T  D DQG N +    L        F + P +         I+  +A++D+E
Sbjct: 491 FVVR---VTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSG--------IITTAASLDYE 539

Query: 433 KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
                   ++A +   P   +S+A V + L D NDN P+F   +Y A +PE    G+  +
Sbjct: 540 LEPQPQLIVVATDGGLPP-LASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL 598

Query: 493 AVTAVDPDTGPWGEVKYS----TYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYV 548
            VTA D D+GP+G + YS       +G+  F I   +G + T      D +  + ++F V
Sbjct: 599 QVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRD-QGPSSFDFTV 657

Query: 549 KAEDMEGKYSVAEVFITLLDVNDHPPQF-----GKSVQKKTMVLGTPVKIEAIDEDAEEP 603
            A D  G  S+  V + L D ND+PPQF       S+  ++      +++ A D D +  
Sbjct: 658 TAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD-QGS 716

Query: 604 NNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
           +  + Y I       +F ++  +G          L     +    + +  LE+ A+D G 
Sbjct: 717 HGRLSYHILAGNSPPLFTLDEQSG---------LLTVAWPLARRANSVVQLEIGAEDGGG 767

Query: 664 PSFSTTALLKIDI 676
                +A + I I
Sbjct: 768 LQAEPSARVDISI 780



 Score =  180 bits (456), Expect = 6e-45
 Identities = 184/652 (28%), Positives = 284/652 (43%), Gaps = 57/652 (8%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDE 103
            L E+ P G+ + TL  TDP+    +  +++   +   FS+DP  G +T +  LDRE ++E
Sbjct: 1658 LRENNPPGTSLLTLRATDPDVGA-NGQVTYGGVSSESFSLDPDTGVLTTLRALDREEQEE 1716

Query: 104  IEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV 160
            I   +   D  +   L    V + V D ND AP F        VPE     ++   + A 
Sbjct: 1717 INLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LRAS 1775

Query: 161  DRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGR 218
            D D G+ G + Y + +      F +D  SG         LD E      + + A+DGG  
Sbjct: 1776 DPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR--PLDREVEPAFQLRIEARDGG-- 1831

Query: 219  LHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKP 278
                    SAT  +TV V D  D AP F    Y   V ED   G+ +L++ A D D G  
Sbjct: 1832 ----QPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGAN 1887

Query: 279  NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVP 338
              + Y L  G  GAF +  +SG +    +  + Q   Y   V   + + AG      TV 
Sbjct: 1888 GHVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG--PLSTTVS 1945

Query: 339  VTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPP--QGEILRGLKITVNDSDQGANAKFN 396
            VTI + D+N+H PTF     P +   L +    P      L    +   D D GANA   
Sbjct: 1946 VTITVRDVNDHAPTF-----PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASIL 2000

Query: 397  LQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTA 456
             +L G        P T ++     I V  S      + +VL   ++A ++  P + S+T 
Sbjct: 2001 YRLAG-----TPPPGTTVDSYTGEIRVARSPVALGPRDRVLF--IVATDLGRPAR-SATG 2052

Query: 457  DVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY-GTG 515
             +++ L    +  P+F      A I ENAP G+ +V+  AV    G  G + YS   G  
Sbjct: 2053 VIIVGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE 2111

Query: 516  ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQ 575
               F I PSTG I  +    LD E + R    ++AE   G ++   + +TL D ND+ P+
Sbjct: 2112 KGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAES-GGAFAFTVLTLTLQDANDNAPR 2170

Query: 576  FGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPA-NVFDINSHTGEI 629
            F +      + +   + G  +++EA D D +     + YS+  ++PA  +F ++  TG I
Sbjct: 2171 FLRPHYVAFLPESRPLEGPLLQVEADDLD-QGSGGQISYSLAASQPARGLFHVDPTTGTI 2229

Query: 630  WLKNSIRSLDALHNITPGRDCLWS---LEVQAKDRGSPSFSTTALLKIDITD 678
                +   LD           +W+   L + A DRGSP+   +A L + + D
Sbjct: 2230 ---TTTAILDRE---------IWAETRLVLMATDRGSPALVGSATLTVMVID 2269



 Score =  171 bits (432), Expect = 3e-42
 Identities = 182/675 (26%), Positives = 284/675 (42%), Gaps = 77/675 (11%)

Query: 33   GSTNGNMALFSLPEDTPVGSHVYTL-NGTDPEGDPISYHISFDPSTRSVFSVDPTFGNIT 91
            GS  G++A    PE   VG+  YTL  G DPEG                F++D   G + 
Sbjct: 1348 GSLLGSVAA---PEPAGVGALTYTLVGGADPEG---------------TFALDAASGRLY 1389

Query: 92   LVEELDREREDEIEAIISISDGLNLVAEKVV---ILVTDANDEAPRFIQEPYVALVPEDI 148
            L   LD E      A+   ++G      +++   + V D N+ AP F ++P    +PE+ 
Sbjct: 1390 LARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENP 1449

Query: 149  PAGSIIFKVHAVDRD-TGSGGSVTYFLQNLHSP---FAVDRHSGVLRLQAGATLDYERSR 204
              G+ ++   A D D  G    V Y L     P     +D  +G L    G  LD E + 
Sbjct: 1450 EPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRG--LDRETTP 1507

Query: 205  THYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSE 264
               + V A D   R   A    +A  +  V V D  D APVF  +P    + ED  PG  
Sbjct: 1508 ALLLLVEATD---RPANASRRRAARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPA 1563

Query: 265  VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTE 324
             L VVA D D G+  R+ Y L +G DG F ++ ++GA+S+ +    L RE    HV    
Sbjct: 1564 ALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVR---PLDREQRAEHVLTVV 1620

Query: 325  MSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITV 384
             S  GSP   AT  +T+ + D+N+  PTF      Q  + + + E+ P G  L  L+ T 
Sbjct: 1621 ASDHGSPPRSATQVLTVSVADVNDEAPTF-----QQQEYSVLLRENNPPGTSLLTLRAT- 1674

Query: 385  NDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAV 444
             D D GAN +     V     F + P T         ++    A+D E+ + +   + A 
Sbjct: 1675 -DPDVGANGQVTYGGVSSES-FSLDPDTG--------VLTTLRALDREEQEEINLTVYAQ 1724

Query: 445  EVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPW 504
            +  +P + +    V + + D ND+ P F S +    +PE      ++  + A DPD G  
Sbjct: 1725 DRGSPPQLTHVT-VRVAVEDENDHAPTFGSAHLSLEVPE-GQDPQTLTMLRASDPDVGAN 1782

Query: 505  GEVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAE 561
            G+++Y    G  +  F++  ++G   T     LD E    +   ++A D       +   
Sbjct: 1783 GQLQYRILDGDPSGAFVLDLASGEFGTM--RPLDREVEPAFQLRIEARDGGQPALSATLL 1840

Query: 562  VFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITH---AEPAN 618
            + +T+LD NDH P F        +    P     +   A +P+   +  +T+   A  A 
Sbjct: 1841 LTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAG 1900

Query: 619  VFDINSHTGEIWLKNSIRSLDALHNITPGRDC-LWSLEVQAKDRGSPS-FSTTALLKIDI 676
             F +   +GE      +R+  AL        C  ++  V A D  +    STT  + I +
Sbjct: 1901 AFLLEPSSGE------LRTAAALDR----EQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950

Query: 677  TD----AETLSRSPM 687
             D    A T   SP+
Sbjct: 1951 RDVNDHAPTFPTSPL 1965



 Score =  165 bits (417), Expect = 2e-40
 Identities = 175/670 (26%), Positives = 288/670 (42%), Gaps = 70/670 (10%)

Query: 31   GVGSTNGNMALFSL-PEDTPVGSH---VYTLNGTDPEGDPISYHISFDPSTRSVFSVDPT 86
            G   +   +AL +L  ED   G++   +Y L GT P G  +  +       RS  ++ P 
Sbjct: 1973 GPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPR 2032

Query: 87   FGNITLVE-ELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVP 145
               + +V  +L R        II    GL   AE+            PRF +    A + 
Sbjct: 2033 DRVLFIVATDLGRPARSATGVIIV---GLQGEAER-----------GPRFPRASSEATIR 2078

Query: 146  EDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYERS 203
            E+ P G+ I    AV    G+ G +TY +   N    F++   +G + +++   LD+E S
Sbjct: 2079 ENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVS 2137

Query: 204  RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGS 263
                + + A+ GG           A T +T+ ++D  D AP F+   Y  ++ E      
Sbjct: 2138 PRLRLVLQAESGGA---------FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEG 2188

Query: 264  EVLKVVAMDGDRGKPNRILYSLVNGND--GAFEINETSGAISITQSPAQLQREVYELHVQ 321
             +L+V A D D+G   +I YSL       G F ++ T+G I+ T   A L RE++     
Sbjct: 2189 PLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTT---AILDREIWAETRL 2245

Query: 322  VTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLK 381
            V   +  GSPA   +  +T+ ++D N++ PT      PQ  +EL ++E    G  +   +
Sbjct: 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPTI-----PQ-PWELRVSEDALLGSEI--AQ 2297

Query: 382  ITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKL 441
            +T ND D G    + L   GP+  F V         +    V  +  +DFE+      +L
Sbjct: 2298 VTGNDVDSGPVLWYVLSPSGPQDPFSV--------GRYGGRVSLTGPLDFEQCDRYQLQL 2349

Query: 442  LAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDT 501
            LA +          A++ + + D NDN P F    Y   + E+ P GS++++V+A D D+
Sbjct: 2350 LAHD----GPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405

Query: 502  GPWGEVKYSTYGTGADLFLIHPSTGLIYT-QPWASLDAEATARYNFYVKAED--MEGKYS 558
            G  G + Y    + AD F + P+ G ++T     +L  + +   +  ++A D    G+ +
Sbjct: 2406 GANGHISYH-LASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAA 2464

Query: 559  VAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDYSITH 613
             A V + L D NDH P F  S  +  +    P     + +EA D D    +  VDYSI  
Sbjct: 2465 RATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIIS 2524

Query: 614  AEPANVFDINSHTGEIWLK-----NSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFST 668
                 VF +     E          ++  L  L  +       ++L V A DRG P  S+
Sbjct: 2525 GNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSS 2584

Query: 669  TALLKIDITD 678
               + + + D
Sbjct: 2585 VVPVTVTVLD 2594



 Score =  153 bits (387), Expect = 6e-37
 Identities = 165/644 (25%), Positives = 273/644 (42%), Gaps = 64/644 (9%)

Query: 19   AQANFAPHFFDNGVGSTNGNMALFS---LPEDTPVGSHVYTLNGTDPE---GDPISYHIS 72
            A+A F  H  D    +   +  L+    LPE    GS V  +   DP+      ++Y ++
Sbjct: 454  AEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA 513

Query: 73   FDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG-LNLVAEKVVILVT--DAN 129
                T   FS+DPT G IT    LD E E + + I+  +DG L  +A    + V   D N
Sbjct: 514  PGAHTHW-FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVN 572

Query: 130  DEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL-----QNLHSPFAVD 184
            D  P+F +  Y A +PE    G+   +V A D D+G  G ++Y L      +   PF +D
Sbjct: 573  DNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRID 632

Query: 185  RHSGVLRLQAGATLDYERSRTHY-ITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             HSG   +    TLD ++  + +  TV A DGGG          +   V V + D  D  
Sbjct: 633  AHSG--DVCTTRTLDRDQGPSSFDFTVTAVDGGG--------LKSMVYVKVFLSDENDNP 682

Query: 244  PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA-FEINETSGAI 302
            P F    Y   +   + PG+ VL++ A D D+G   R+ Y ++ GN    F ++E SG +
Sbjct: 683  PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLL 742

Query: 303  SITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNR 362
            ++    A+    V +L +   +    G   A+ +  V I IV     PP F      Q +
Sbjct: 743  TVAWPLARRANSVVQLEIGAED---GGGLQAEPSARVDISIVPGTPTPPIF-----EQLQ 794

Query: 363  FELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTVLNEAQVT 420
            +  S+ E    G     + I    +  G  A   L L G  PRG+F +          V+
Sbjct: 795  YVFSVPEDVAPGT---SVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSL--------DAVS 843

Query: 421  IIVENSAAIDFEKSKVLTFKLLAVEVNT----PEKFSSTADVVIQLLDTNDNVPKFDSLY 476
             +++    +D E    L   +L +EV      P  F+  A V + L D NDN P F +  
Sbjct: 844  GLLQTLRPLDRE----LLGPVLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPE 898

Query: 477  YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASL 536
                +P N   G+ +  + A+DPD+G    V ++    G   F + P+TG  + +    L
Sbjct: 899  DTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTG--HVRLMRPL 956

Query: 537  DAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDH--PPQFGKSVQKKTMVLGTPVK 592
                   +   ++A D     + S   + + + DV      P+F     +  +  GT   
Sbjct: 957  GPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAG 1016

Query: 593  IEAIDEDAEEPN-NLVDYSITHAEPANVFDINSHTGEIWLKNSI 635
             + +   A+ P+   + Y +     ++ F +   +G +W++ ++
Sbjct: 1017 TQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAAL 1060



 Score =  152 bits (384), Expect = 1e-36
 Identities = 188/696 (27%), Positives = 306/696 (43%), Gaps = 78/696 (11%)

Query: 46   EDTPVGSHVYTLNGTDPE-GDPISYHISFDPSTR--SVFSVDPTFGNITLVEELDRERED 102
            E  P G  V  ++ +DP+ GD    ++S +      ++ + D     + +   LDRE  D
Sbjct: 377  EAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERD 436

Query: 103  EIEAIISISDGLN--LVAEKVVIL-VTDANDEAPRFIQEPYVALVPEDIPA----GSIIF 155
                 ++ +D  +  L AE   +L VTD ND AP F ++ Y    PE +P     GS + 
Sbjct: 437  AYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYR---PEPLPEVALPGSFVV 493

Query: 156  KVHAVDRDTGSGGSVTYFLQ-NLHSP-FAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
            +V A D D G+ G VTY L    H+  F++D  SG++     A+LDYE      + VVA 
Sbjct: 494  RVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIIT--TAASLDYELEPQPQLIVVAT 551

Query: 214  DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG 273
            DGG          +++ TV+V ++DV D  P F  T Y   + E T PG+  L+V A D 
Sbjct: 552  DGGLP------PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDA 605

Query: 274  DRGKPNRILYSLVNGNDGA----FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAG 329
            D G    + YSL  G   +    F I+  SG +  T++   L R+        T  +  G
Sbjct: 606  DSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRT---LDRDQGPSSFDFTVTAVDG 662

Query: 330  SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
                ++ V V + + D N++PP FY        +  S++   P G  +  L++  +D DQ
Sbjct: 663  G-GLKSMVYVKVFLSDENDNPPQFY-----PREYAASISAQSPPGTAV--LRLRAHDPDQ 714

Query: 390  GANAKFNLQLVGPRG--IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
            G++ + +  ++      +F +  Q+ L      +    ++ +  E         +  E  
Sbjct: 715  GSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLE---------IGAEDG 765

Query: 448  TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEV 507
               +   +A V I ++      P F+ L YV  +PE+   G+SV  V A +P  G    V
Sbjct: 766  GGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPV 824

Query: 508  KYS-TYGTGADLFLIHPSTGLIYTQPWASLDAEATARY-NFYVKA-EDMEGKYSVAEVFI 564
              S + G    LF +   +GL+ T     LD E         V+A   +   ++VA V +
Sbjct: 825  TLSLSGGDPRGLFSLDAVSGLLQTL--RPLDRELLGPVLELEVRAGSGVPPAFAVARVRV 882

Query: 565  TLLDVNDHPPQFGKSVQKKTMVL------GTPV-KIEAIDEDAEEPNNLVDYSITHAEPA 617
             L DVND+ P F     + T++L      GTP+  + A+D D+   N+ V +++  A   
Sbjct: 883  LLDDVNDNSPAF--PAPEDTVLLPPNTAPGTPIYTLRALDPDSGV-NSRVTFTLL-AGGG 938

Query: 618  NVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDIT 677
              F ++  TG + L         +  + P       LE++A+D GSP  ++   L++ + 
Sbjct: 939  GAFTVDPTTGHVRL---------MRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQ 989

Query: 678  DAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVV 713
            D  T   +P         D P    G  AGT    V
Sbjct: 990  DVGTRGLAPRFNSPTYRVDLPS---GTTAGTQVLQV 1022



 Score =  137 bits (346), Expect = 3e-32
 Identities = 171/674 (25%), Positives = 276/674 (40%), Gaps = 80/674 (11%)

Query: 44   LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED- 102
            LP  T  G+ V  +    P+G PI+YH++ + ++ S F ++P  G + +   LDRE ++ 
Sbjct: 1009 LPSGTTAGTQVLQVQAQAPDGGPITYHLAAEGAS-SPFGLEPQSGWLWVRAALDREAQEL 1067

Query: 103  EIEAIISISD-----GLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
             I  ++++S      G       V + + + N+ +PR  ++P    V E+ P G+ + +V
Sbjct: 1068 YILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRV 1127

Query: 158  HAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLRLQAGATLDYERSRTHYITVVAKDGG 216
             A DRD+G  G +TY LQ L       R H     +    TLD E+  ++ + V  +DGG
Sbjct: 1128 FATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGG 1187

Query: 217  GRLHGADVVFSATTTVTVNVEDVQDMAPVFV--------GTPYYGYVYEDTLPGSEVLKV 268
                      S T TV V V D+ D +P F+        G P    V +   PG+ V  +
Sbjct: 1188 SPPR------STTGTVHVAVLDLNDNSPTFLQASGAAGGGLPI--QVPDRVPPGTLVTTL 1239

Query: 269  VAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPA 328
             A D D G+   ILY+L       F ++  SG +       + +R  Y L +   +    
Sbjct: 1240 QAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQ--- 1296

Query: 329  GSPAAQATVPVTIRIVDLNN--HPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
            GSP   A++ + ++++       PP    E  P     + +     +G     L  +V  
Sbjct: 1297 GSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA 1356

Query: 387  SDQGANAKFNLQLVG---PRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
             +          LVG   P G F       L+ A   + +  +  +DFE      ++ L 
Sbjct: 1357 PEPAGVGALTYTLVGGADPEGTF------ALDAASGRLYL--ARPLDFEAGP--PWRALT 1406

Query: 444  VEVNTPEKFSS-TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD-T 501
            V    P    +    V +Q+ D N++ P F        +PEN   G+++    A D D  
Sbjct: 1407 VRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP 1466

Query: 502  GPWGEVKYSTYGTGADL--FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYS- 558
            GP  +V+Y        +    +   TG +       LD E T      V+A D     S 
Sbjct: 1467 GPNSDVRYRLLRQEPPVPALRLDARTGALSAP--RGLDRETTPALLLLVEATDRPANASR 1524

Query: 559  ------VAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPN----NLVD 608
                   A VF+T  D ND+ P F  S  +  +    P    A+   A +P+      V 
Sbjct: 1525 RRAARVSARVFVT--DENDNAPVFA-SPSRVRLPEDQPPGPAALHVVARDPDLGEAARVS 1581

Query: 609  YSITHAEPANVFDINSHTGEIWLKNSIRSLD----ALHNITPGRDCLWSLEVQAKDRGSP 664
            Y +      + F ++S TG +   + +R LD    A H +T          V A D GSP
Sbjct: 1582 YRLASGGDGH-FRLHSSTGAL---SVVRPLDREQRAEHVLT----------VVASDHGSP 1627

Query: 665  SFSTTALLKIDITD 678
              S T +L + + D
Sbjct: 1628 PRSATQVLTVSVAD 1641



 Score =  110 bits (275), Expect = 6e-24
 Identities = 96/327 (29%), Positives = 152/327 (46%), Gaps = 40/327 (12%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISF-DPSTRSVFSVDPTFGNITLVEELDR 98
            ++PEDTPVG+ +  +  +D +  P   + + +S  DPS   +F +D + G + L   LD 
Sbjct: 2610 TVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS--GLFELDESSGTLRLAHALDC 2667

Query: 99   EREDEIEAIISISD--GLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFK 156
            E +   + ++  +D  G +     V I V D ND  P F        V E+ P G+++  
Sbjct: 2668 ETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT 2727

Query: 157  VHAVDRDTGSGGSVTYFLQNL------HSPFAVDRHSGVLRLQAGATLDYERSRTHYITV 210
            +HA+D D G+ G + Y L            FA++  +G LR  A    DYE + +  + V
Sbjct: 2728 LHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELR--ARVPFDYEHTESFRLLV 2785

Query: 211  VAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVA 270
             A D G          SA+ TV+V V    +  PVF+   ++  V E    G  +  V A
Sbjct: 2786 GAADAGN--------LSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHVQA 2837

Query: 271  MDGDRGKPNRILYSLVNGNDGAFEINETSGAISI---TQSP----------AQLQREV-Y 316
             D D G    +LYSL   +   F IN+T+GA+ +   +++P           + +RE   
Sbjct: 2838 TDEDGGADGLVLYSLATSSP-YFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPR 2896

Query: 317  ELHVQVTEMSPAGSPAAQATVPVTIRI 343
            EL ++V    P    +  ATVPVT+ I
Sbjct: 2897 ELRLEVIARGPLPG-SRSATVPVTVDI 2922



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 107/399 (26%), Positives = 162/399 (40%), Gaps = 43/399 (10%)

Query: 295 INETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFY 354
           I+E SG +   +   + QR+ Y      T ++P G     ATV VT+R+ D+N+H P F 
Sbjct: 94  IDEHSGVVRTARVLDREQRDRYRF----TAVTPDG-----ATVEVTVRVADINDHAPAF- 143

Query: 355 GESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQG--ANAKFNLQLVGPRGIFRVVPQT 412
               PQ R  L + EH   G   R       D+D G      + L   G    FR+  + 
Sbjct: 144 ----PQARAALQVPEHTAFG--TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRP 197

Query: 413 VLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF 472
             +   V  +V  +  +D E       +L A +  +P +  + A + + LLD ND+ P F
Sbjct: 198 GPDGTPVPELVV-TGELDRENRSHYMLQLEAYDGGSPPR-RAQALLDVTLLDINDHAPAF 255

Query: 473 DSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS---TYGTGADLFLIHPSTGLIY 529
           +   Y A + E+   GS V+ V A D D G  G V Y        G   F I   TGL+ 
Sbjct: 256 NQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQ 315

Query: 530 TQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFIT--LLDVNDHPPQF--------GKS 579
            +    LD E    +   V+A D      +   F+T  + D ND+ P          G  
Sbjct: 316 LE--RPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSP 373

Query: 580 VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD 639
              +    G  V   ++ +  +     V+ S+   E    F +++    I+L    R LD
Sbjct: 374 QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGE--GHFALSTQDSVIYLVCVARRLD 431

Query: 640 ALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
                   RD  ++L V A D GSP     A   + +TD
Sbjct: 432 -----REERDA-YNLRVTATDSGSPPLRAEAAFVLHVTD 464



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 83/318 (26%), Positives = 139/318 (43%), Gaps = 38/318 (11%)

Query: 423 VENSAAIDFEKSKVLTFKLLAVEVNTPEKFSS------TADVVIQLLDTNDNVPKFDSLY 476
           V    AID     V T ++L  E     +F++      T +V +++ D ND+ P F    
Sbjct: 88  VGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQAR 147

Query: 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTG--------L 527
              ++PE+   G+      A D D G  G   Y+  G GA + F +    G        L
Sbjct: 148 AALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPEL 207

Query: 528 IYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS----VQ 581
           + T     LD E  + Y   ++A D     + + A + +TLLD+NDH P F +S    V 
Sbjct: 208 VVT---GELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVV 264

Query: 582 KKTMVLGTPV-KIEAIDEDAEEPNNLVDYSIT--HAEPANVFDINSHTGEIWLKNSIRSL 638
            +++  G+PV ++ A D DA   N  V Y I    +E    F I++HTG + L+   R L
Sbjct: 265 SESLAPGSPVLQVFASDADA-GVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLE---RPL 320

Query: 639 DALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNP 698
           D        +  +  L VQA+D G+     +A + + + DA   ++  M    +    +P
Sbjct: 321 DF------EQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND-NQPSMTVIFLSADGSP 373

Query: 699 MKAVGVLAGTMATVVAIT 716
             +     G +   ++++
Sbjct: 374 QVSEAAPPGQLVARISVS 391


>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
          Length = 4349

 Score =  186 bits (471), Expect = 1e-46
 Identities = 174/618 (28%), Positives = 287/618 (46%), Gaps = 63/618 (10%)

Query: 96   LDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 155
            LDRE   +    ++ SDG    +  V I V D ND +P+  Q  Y   V ED+  G  I 
Sbjct: 2972 LDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL 3031

Query: 156  KVHAVDRDTGSGGSVTYFLQNLHSP----FAVDRHSGVLRLQAGATLDYERSRTHYITVV 211
            KV A D DT +   +TY   +LH P    F +D H+G   L     LD ER     +   
Sbjct: 3032 KVSATDLDTDTNAQITY---SLHGPGAHEFKLDPHTG--ELTTLTALDRERKDVFNLVAK 3086

Query: 212  AKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAM 271
            A DGGGR   AD+        T++VEDV D AP F  +     V+++T   + V  V A 
Sbjct: 3087 ATDGGGRSCQADI--------TLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFAR 3138

Query: 272  DGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV-YELHVQVTEMSPAGS 330
            D D+G   +++YSL +  +G F I+ T+G I + + P Q++ +   EL V+ +++   G+
Sbjct: 3139 DPDQGANAQVVYSLPDSAEGHFSIDATTGVIRL-EKPLQVRPQAPLELTVRASDL---GT 3194

Query: 331  PAAQATV-PVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQ 389
            P   +T+  VT+ +V L ++ P F          E    + PP  E+L+   +T   +++
Sbjct: 3195 PIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPE----DAPPGTEVLQLATLTRPGAEK 3250

Query: 390  GANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
                 + +     +G FR+       +A+  I+  N A++DFE S    F  +     + 
Sbjct: 3251 TG---YRVVSGNEQGRFRL-------DARTGILYVN-ASLDFETSPKY-FLSIECSRKSS 3298

Query: 450  EKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKY 509
               S    V++ + D N++ P+F    Y  R+ ENA  G  ++ V+A D D     ++ Y
Sbjct: 3299 SSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITY 3358

Query: 510  STYGTGADL--FLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFIT 565
            S  G G  L  F IHP  G +  Q   +LD E  + Y+  ++A D      +   ++ I 
Sbjct: 3359 SLIG-GNQLGHFTIHPKKGEL--QVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQ 3415

Query: 566  LLDVNDHPPQFGKSVQKKTMVLGTPVK---IEAIDEDAEEPNNLVDYS--ITHAEPANVF 620
            + DVND+PP+F +     T+   +P+    ++ I  D + P N   YS  IT     + F
Sbjct: 3416 VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAF 3475

Query: 621  DINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAE 680
             +   T + WL  +         ++      + L++QA D G P  S+   +++ +T+  
Sbjct: 3476 RV---TPDGWLVTA-------EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQS 3525

Query: 681  TLSRS--PMAAFLIQTKD 696
              + S  P+  F+   +D
Sbjct: 3526 HYAPSALPLEIFITVGED 3543



 Score =  176 bits (447), Expect = 6e-44
 Identities = 176/660 (26%), Positives = 293/660 (44%), Gaps = 67/660 (10%)

Query: 42   FSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRS----VFSVDPTFGNITLVEELD 97
            FS PED P GS +  +     + DP+ Y +    +  S    VFS+DP  G I + + +D
Sbjct: 2698 FSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMD 2756

Query: 98   RE-----REDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGS 152
             E     + D +   +  +D ++LV+  V I V D ND  P F  +PY A++ E++P G+
Sbjct: 2757 HESTKLYQIDVMAHCLQNTDVVSLVS--VNIQVGDVNDNRPVFEADPYKAVLTENMPVGT 2814

Query: 153  IIFKVHAVDRDTGSGGSVTYFL-----QNLHSPFAVDRHSG-VLRLQAGATLDYERSRTH 206
             + +V A+D+DTG  G V+Y L      N+H  FA+D  SG +  LQ    LD E  +T+
Sbjct: 2815 SVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQ---ELDCETCQTY 2871

Query: 207  YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL 266
            +  VVA D     HG  +  S+   V V++ D  D AP F    Y G V E++ PG  V 
Sbjct: 2872 HFHVVAYD-----HGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVA 2926

Query: 267  KVVAMDGDRGKPNRILYSLVNGND--GAFEINETSGAISITQSPAQLQREVYELHVQVTE 324
             +  +D D  + NR +   +   D  G F I++      I+      +    +  ++VT 
Sbjct: 2927 TLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVT- 2985

Query: 325  MSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITV 384
               A     QA+V V I ++D+N++ P        Q  +   ++E    G  +  LK++ 
Sbjct: 2986 ---ASDGKFQASVTVEIFVLDVNDNSP-----QCSQLLYTGKVHEDVFPGHFI--LKVSA 3035

Query: 385  NDSDQGANAKFNLQLVGPRG-IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
             D D   NA+    L GP    F++ P T     ++T +     A+D E+  V  F L+A
Sbjct: 3036 TDLDTDTNAQITYSLHGPGAHEFKLDPHT----GELTTL----TALDRERKDV--FNLVA 3085

Query: 444  VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGP 503
               +   + S  AD+ + + D NDN P+F   +    + +N    + V  V A DPD G 
Sbjct: 3086 KATDGGGR-SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA 3144

Query: 504  WGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY---SVA 560
              +V YS   +    F I  +TG+I  +    L     A     V+A D+       ++ 
Sbjct: 3145 NAQVVYSLPDSAEGHFSIDATTGVIRLE--KPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202

Query: 561  EVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAID-EDAEEPN-NLVDYSITHAEPAN 618
             V ++++ + D+ P F  +     +    P   E +       P      Y +       
Sbjct: 3203 TVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQG 3262

Query: 619  VFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
             F +++ TG +++  S+         +P     + L ++   + S S S    + ++ITD
Sbjct: 3263 RFRLDARTGILYVNASLD-----FETSP----KYFLSIECSRKSSSSLSDVTTVMVNITD 3313



 Score =  174 bits (442), Expect = 2e-43
 Identities = 169/635 (26%), Positives = 279/635 (43%), Gaps = 65/635 (10%)

Query: 81   FSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPY 140
            F ++ + G I++     +  +      +  SDG+      V I  T+AN  +P F Q  Y
Sbjct: 2427 FFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLY 2486

Query: 141  VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQN--LHSPFAVDRHSGVLRLQAGATL 198
             A + E+   G+ +  + A+D+D+G  G++ Y + N      F+++ +  +  LQ    L
Sbjct: 2487 EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQ---KL 2543

Query: 199  DYERS--RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
            D E S  R   I V+A+DGGGR+        A  TV + + D  D  P F  + Y   + 
Sbjct: 2544 DRENSTERVIAIKVMARDGGGRV--------AFCTVKIILTDENDNPPQFKASEYTVSIQ 2595

Query: 257  EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND---GAFEINETSGAISITQSPAQLQR 313
             +    S V++V+A D D G+   + YS VN  D      EIN  +G + +  S   L+ 
Sbjct: 2596 SNVSKDSPVIQVLAYDADEGQNADVTYS-VNPEDLVKDVIEINPVTGVVKVKDSLVGLEN 2654

Query: 314  EVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQ 373
            +  +  ++  +    G P   + VPV +++V      P F      +  +  S  E  P+
Sbjct: 2655 QTLDFFIKAQD---GGPPHWNSLVPVRLQVVPKKVSLPKF-----SEPLYTFSAPEDLPE 2706

Query: 374  GEILRGLK-ITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 432
            G  +  +K +   D    +  +         G+F + P T         +++    +D E
Sbjct: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTG--------VIKVRKPMDHE 2758

Query: 433  KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV 492
             +K+    ++A  +   +   S   V IQ+ D NDN P F++  Y A + EN P G+SV+
Sbjct: 2759 STKLYQIDVMAHCLQNTD-VVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI 2817

Query: 493  AVTAVDPDTGPWGEVKYSTYGTGA----DLFLIHPSTGLIYTQPWASLDAEATARYNFYV 548
             VTA+D DTG  G+V Y           +LF I   +G I T     LD E    Y+F+V
Sbjct: 2818 QVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITT--LQELDCETCQTYHFHV 2875

Query: 549  KAEDMEGK----YSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDED 599
             A D  G+     S A V +++ D ND+ P+F     + ++V  +        ++ +D D
Sbjct: 2876 VAYD-HGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDAD 2934

Query: 600  AEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAK 659
              E N  V   IT  +P   F I S  G+ W  +S ++LD  H         + L V A 
Sbjct: 2935 ISEQNRQVTCYITEGDPLGQFGI-SQVGDEWRISSRKTLDREHT------AKYLLRVTAS 2987

Query: 660  DRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQT 694
            D    +  T  +  +D+ D      SP  + L+ T
Sbjct: 2988 DGKFQASVTVEIFVLDVND-----NSPQCSQLLYT 3017



 Score =  169 bits (427), Expect = 1e-41
 Identities = 166/603 (27%), Positives = 263/603 (43%), Gaps = 56/603 (9%)

Query: 46   EDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            ED   G  +  ++ TD + D    I+Y +   P     F +DP  G +T +  LDRER+D
Sbjct: 3022 EDVFPGHFILKVSATDLDTDTNAQITYSLH-GPGAHE-FKLDPHTGELTTLTALDRERKD 3079

Query: 103  EIEAIISISDGLNLVAEKVVIL-VTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVD 161
                +   +DG     +  + L V D ND APRF        V ++    + +  V A D
Sbjct: 3080 VFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARD 3139

Query: 162  RDTGSGGSVTYFL-QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLH 220
             D G+   V Y L  +    F++D  +GV+RL+    L         +TV A D      
Sbjct: 3140 PDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEK--PLQVRPQAPLELTVRASD-----L 3192

Query: 221  GADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNR 280
            G  +  S   TVTV+V  ++D  PVF+ T +   V ED  PG+EVL++  +   R    +
Sbjct: 3193 GTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLT--RPGAEK 3250

Query: 281  ILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPV 339
              Y +V+GN+ G F ++  +G + +    A L  E    +    E S   S +      V
Sbjct: 3251 TGYRVVSGNEQGRFRLDARTGILYVN---ASLDFETSPKYFLSIECSRKSSSSLSDVTTV 3307

Query: 340  TIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQL 399
             + I D+N H P F     PQ+ +   + E+   G+++  L ++  D D   N+     L
Sbjct: 3308 MVNITDVNEHRPQF-----PQDPYSTRVLENALVGDVI--LTVSATDEDGPLNSDITYSL 3360

Query: 400  VGPR--GIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTAD 457
            +G    G F + P+    E QV      + A+D E++   + KL A +   P     T D
Sbjct: 3361 IGGNQLGHFTIHPKK--GELQV------AKALDREQASSYSLKLRATDSGQPPLHEDT-D 3411

Query: 458  VVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS---TYGT 514
            + IQ+ D NDN P+F  L Y   + EN+P GS V+ +   DPD+ P     YS   T G 
Sbjct: 3412 IAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDS-PENGPPYSFRITKGN 3470

Query: 515  GADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDH 572
                F + P   L+  +    L   A   Y   ++A D  +    S+  V + + + + +
Sbjct: 3471 NGSAFRVTPDGWLVTAE---GLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHY 3527

Query: 573  PP-----QFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEP-ANVFDINSHT 626
             P     +   +V +     G   KI A D D   P + + YS+   E     F + +  
Sbjct: 3528 APSALPLEIFITVGEDEFQGGMVGKIHATDRD---PQDTLTYSLAEEETLGRHFSVGAPD 3584

Query: 627  GEI 629
            G+I
Sbjct: 3585 GKI 3587



 Score =  163 bits (413), Expect = 6e-40
 Identities = 182/689 (26%), Positives = 301/689 (43%), Gaps = 70/689 (10%)

Query: 46   EDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            E  P+ + +  L  TDP+      + Y I+ D +    F ++   G +T+   LD E  +
Sbjct: 726  ESVPINTPLARLAATDPDAGFNGKLVYVIA-DGNEEGCFDIELETGLLTVAAPLDYEATN 784

Query: 103  EIEAIISISDGLNLVAEK----VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVH 158
                 +++ D L    +     + + V D ND APRF    Y   + ED   G+ I ++ 
Sbjct: 785  FYILNVTVYD-LGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELT 843

Query: 159  AVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGR 218
              D D+   G V Y L +    F++   +G   L     LD E    + + V A+D   +
Sbjct: 844  TKDADSEDNGRVRYTLLSPTEKFSLHPLTG--ELVVTGHLDRESEPRYILKVEARDQPSK 901

Query: 219  LHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKP 278
             H    +FS T  + + +EDV D +P  +       V ED  PG+ +  + A D D G  
Sbjct: 902  GHQ---LFSVTDLI-ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA 957

Query: 279  NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQAT-- 336
              + Y L++G  G F ++  +GA+ + +     +R  Y L +  ++    G P A+ T  
Sbjct: 958  GEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWASD---GGRPLARRTLC 1014

Query: 337  -VPVTIRIVDLNNHPPTF--YGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
             V V +  V+ N HPP F  +   G        + E+ P G  +  + +   D D G + 
Sbjct: 1015 HVEVIVLDVNENLHPPHFASFVHQG-------QVQENSPSGTQV--IVVAAQDDDSGLDG 1065

Query: 394  KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS 453
            +    L    G+         +  Q T +++  A +D E +      +LAV+  +    S
Sbjct: 1066 ELQYFLRAGTGL------AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVP-LS 1118

Query: 454  STADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TY 512
            S  +V I++ D NDN P+     +   I E+AP G+SV+ + A DPD+   G++ ++ T 
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178

Query: 513  GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVN 570
            G     F+IHP TGL+ T     LD E    +   V   D       S + V + +LDVN
Sbjct: 1179 GNYMGFFMIHPVTGLLSTA--QQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236

Query: 571  DHPPQFGKSV------QKKTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDIN 623
            D+PP F   +      ++ + V   PV ++ A D D E  N  V YSI  ++    F I+
Sbjct: 1237 DNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLD-EGLNGRVTYSIEDSD-EEAFSID 1294

Query: 624  SHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETLS 683
              TG +   ++  + +  +NI         L ++A D G P  S +  L I+       S
Sbjct: 1295 LVTGVVSSSSTFTAGE--YNI---------LTIKATDSGQPPLSASVRLHIEWIPWPRPS 1343

Query: 684  RSPMA------AFLIQTKDNPMKAVGVLA 706
              P+A      +F +   D     VGV++
Sbjct: 1344 SIPLAFDETYYSFTVMETDPVNHMVGVIS 1372



 Score =  163 bits (412), Expect = 7e-40
 Identities = 172/667 (25%), Positives = 294/667 (44%), Gaps = 80/667 (11%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED 102
            ++ +D+PV   V   +  + +   ++Y ++ +   + V  ++P  G + + + L      
Sbjct: 2597 NVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ 2655

Query: 103  EIEAIISISDG------------LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPA 150
             ++  I   DG            L +V +KV +         P+F +  Y    PED+P 
Sbjct: 2656 TLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSL---------PKFSEPLYTFSAPEDLPE 2706

Query: 151  GSIIFKVHAVDRDTGSGGSVTYFL-------QNLHSPFAVDRHSGVLRLQAGATLDYERS 203
            GS I  V AV     +   V Y L        N    F++D  +GV++++    +D+E +
Sbjct: 2707 GSEIGIVKAV----AAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRK--PMDHEST 2760

Query: 204  RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGS 263
            + + I V+A      L   DVV  +  +V + V DV D  PVF   PY   + E+   G+
Sbjct: 2761 KLYQIDVMAHC----LQNTDVV--SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGT 2814

Query: 264  EVLKVVAMDGDRGKPNRILYSLVNGNDGA-----FEINETSGAISITQSPAQLQREVYEL 318
             V++V A+D D G+  ++ Y L + + G+     F I+  SG I+  Q       + Y  
Sbjct: 2815 SVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQELDCETCQTYHF 2873

Query: 319  HVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILR 378
            HV   +       ++QA V V+I   D N++ P F  E      +  S+ E+   GE++ 
Sbjct: 2874 HVVAYDHGQTIQLSSQALVQVSI--TDENDNAPRFASEE-----YRGSVVENSEPGELVA 2926

Query: 379  GLKITVND-SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVL 437
             LK    D S+Q       +    P G F +    V +E +++    +   +D E     
Sbjct: 2927 TLKTLDADISEQNRQVTCYITEGDPLGQFGI--SQVGDEWRIS----SRKTLDREH---- 2976

Query: 438  TFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAV 497
            T K L     +  KF ++  V I +LD NDN P+   L Y  ++ E+   G  ++ V+A 
Sbjct: 2977 TAKYLLRVTASDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSAT 3036

Query: 498  DPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY 557
            D DT    ++ YS +G GA  F + P TG + T    +LD E    +N   KA D  G+ 
Sbjct: 3037 DLDTDTNAQITYSLHGPGAHEFKLDPHTGELTT--LTALDRERKDVFNLVAKATDGGGRS 3094

Query: 558  SVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPA 617
              A++ + + DVND+ P+F  S     +   T VK       A +P+   +  + ++ P 
Sbjct: 3095 CQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPD 3154

Query: 618  NV---FDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSP-SFSTTALLK 673
            +    F I++ TG I L+  ++       + P       L V+A D G+P   ST   + 
Sbjct: 3155 SAEGHFSIDATTGVIRLEKPLQ-------VRP--QAPLELTVRASDLGTPIPLSTLGTVT 3205

Query: 674  IDITDAE 680
            + +   E
Sbjct: 3206 VSVVGLE 3212



 Score =  149 bits (375), Expect = 1e-35
 Identities = 185/773 (23%), Positives = 316/773 (40%), Gaps = 79/773 (10%)

Query: 42   FSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSV-FSVDPTFGNITLVEELDRER 100
            F++ E  PV   V  ++    EG P  +  +     + + F ++ T G+I +   LD  R
Sbjct: 1356 FTVMETDPVNHMVGVIS---VEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRR 1412

Query: 101  EDEIEAIISISDGLNLVAEKV-VILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHA 159
                   + ++DG   +A +V + ++ + N   P+F++  Y   VP+D   G  + +V A
Sbjct: 1413 RSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQA 1472

Query: 160  VDRDTGSGGSVTYFLQNLHSP-----FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 214
            +D+D G   S+ Y +     P     F +D  SGVL       L    S+ H +TV+ +D
Sbjct: 1473 IDQDKGK--SLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVMVRD 1529

Query: 215  GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGD 274
                +    V       VT++VED     P F    Y   V +   PG+E+L+V AMD D
Sbjct: 1530 QEIPIKRNFV------WVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583

Query: 275  RGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 333
            RG    + YSL+ GN +G F IN   G I++ Q   Q     + L V+  +    GSP  
Sbjct: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQ---GSPQW 1640

Query: 334  QATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANA 393
                 V I +   +   P F      ++ + + + E  P G       I +  +   +  
Sbjct: 1641 HDLATVIIHVYPSDRSAPIF-----SKSEYFVEIPESIPVGS-----PILLVSAMSPSEV 1690

Query: 394  KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFS 453
             + L+     G+F +   + L   Q  +          +  K+ +++L     N    F+
Sbjct: 1691 TYELREGNKDGVFSMNSYSGLISTQKKL----------DHEKISSYQLKIRGSNMAGAFT 1740

Query: 454  STADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVV-------AVTAVDPDTGPWGE 506
                VV+ ++D NDN P F    +V +I E AP  S ++        + A D D      
Sbjct: 1741 DVM-VVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSL 1799

Query: 507  VKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY----SVAE 561
            + Y      A   F I PS G +     + +D E+   + F V   D           A+
Sbjct: 1800 LVYKILEPEALKFFKIDPSMGTLTIV--SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQ 1857

Query: 562  VFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFD 621
            V I + DVND PP+F + + +  +V      +E +   A + ++ V+YSI          
Sbjct: 1858 VIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAVT 1917

Query: 622  INSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAET 681
            I+  TG I + N      A   ++        L ++A D     +  TAL+KI +T    
Sbjct: 1918 IHPVTGSISVLN-----PAFLGLSR------KLTIRASD---GLYQDTALVKISLTQVLD 1963

Query: 682  LS-RSPMAAFLIQTKDN--PMKAVGVLA--GTMATVVAITVLISTATFWRNKKSNKVLPM 736
             S +     +    K+N    KA+ +L   G          L++    +   +S  VL  
Sbjct: 1964 KSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQT 2023

Query: 737  RRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNNNSPESSLLP 789
            R V   R       + +E   +++ +   + +++     E+ N+N P+   LP
Sbjct: 2024 RGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVS--IEDVNDNPPKFKHLP 2074



 Score =  146 bits (369), Expect = 7e-35
 Identities = 157/581 (27%), Positives = 254/581 (43%), Gaps = 76/581 (13%)

Query: 44  LPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSV-FSVDPTFGNITLVEELDRERED 102
           L E +P GS V  +  T P    + Y +   PS+ +V F ++   G IT  + +D     
Sbjct: 371 LSEFSPPGSRVVMVRVT-PAFPNLQYVLK--PSSENVGFKLNARTGLITTTKLMDFHDRA 427

Query: 103 EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDR 162
             +  I  S G    +  VVI + D N+ AP F +  Y   + E+IP G+ +  V A DR
Sbjct: 428 HYQLHIRTSPGQ--ASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDR 485

Query: 163 DTGSGGSVTYFLQNLHS-PFAVDRHSGVLRLQAGATLDYE-RSRTHYITVVAKDGGGRLH 220
           D G  G VTY +    + PF++D + G+  +     +DYE   R +   V A D G    
Sbjct: 486 DHGENGYVTYSIAGPKALPFSIDPYLGI--ISTSKPMDYELMKRIYTFRVRASDWGSPFR 543

Query: 221 GADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNR 280
               V     ++ + + ++ D  P+F      G + +D   G  ++ + A+D D  +   
Sbjct: 544 REKEV-----SIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQN 596

Query: 281 ILYSLVNGND-GAFEINETSGAISITQSPAQL---QREVYELHVQVTEMSPAGSPAA--- 333
           + Y +V+GN+   F++N  SG IS+ +    L   Q   Y L +  ++     SP     
Sbjct: 597 LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNI 656

Query: 334 ------QATVPVT--------------IRIVDLNNHPPT---FYGESGPQ-NRFELSMNE 369
                    VPVT              +  + L N   +   F   S  Q N +     +
Sbjct: 657 TVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFED 716

Query: 370 HPPQG-EILRGL-------KITVNDSDQGANAKFNLQLV--GPRGIFRVVPQTVLNEAQV 419
           H PQ  ++L  +       ++   D D G N K    +      G F +  +T L    +
Sbjct: 717 HFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGL----L 772

Query: 420 TIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVA 479
           T+    +A +D+E +      +   ++ TP+K SS   + + + D NDN P+F    Y  
Sbjct: 773 TV----AAPLDYEATNFYILNVTVYDLGTPQK-SSWKLLTVNVKDWNDNAPRFPPGGYQL 827

Query: 480 RIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTG-LIYTQPWASLDA 538
            I E+   G+++  +T  D D+   G V+Y T  +  + F +HP TG L+ T     LD 
Sbjct: 828 TISEDTEVGTTIAELTTKDADSEDNGRVRY-TLLSPTEKFSLHPLTGELVVT---GHLDR 883

Query: 539 EATARYNFYVKAEDMEGK----YSVAEVFITLLDVNDHPPQ 575
           E+  RY   V+A D   K    +SV ++ ITL DVND+ PQ
Sbjct: 884 ESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQ 924



 Score =  141 bits (355), Expect = 3e-33
 Identities = 178/697 (25%), Positives = 288/697 (41%), Gaps = 92/697 (13%)

Query: 43   SLPEDTPVGSHVYTLNGTDP---EGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            +L E+ P G+ V  +  TD    E   ++Y I+   +    FS+DP  G I+  + +D E
Sbjct: 466  TLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALP--FSIDPYLGIISTSKPMDYE 523

Query: 100  REDEIEAI-ISISD-GLNLVAEKVVIL---VTDANDEAPRFIQEPYVALVPEDIPAGSII 154
                I    +  SD G     EK V +   + + ND  P F +      + +D P G  I
Sbjct: 524  LMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSI 583

Query: 155  FKVHAVDRDT--------GSGGSVTYFLQN-------LHSPF----AVDRHSGVLRLQAG 195
              + A+D D          SG  + YF  N       L  PF    A    S  L++ A 
Sbjct: 584  MTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITAS 643

Query: 196  ATLDYERSRTHYITVVAKDGGGRLH------GADVVFSATTTVTVNVEDVQDMAPVFVGT 249
               +Y    T  ITVV KD    +       G    F+ T    + +++ +     F   
Sbjct: 644  DGKNYASPTTLNITVV-KDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSL 702

Query: 250  P-----YYGYVYEDTLPGS-----------EVLKVVAMDGDRGKPNRILYSLVNGND-GA 292
                  +Y   +ED  P S            + ++ A D D G   +++Y + +GN+ G 
Sbjct: 703  STYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGC 762

Query: 293  FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPT 352
            F+I   +G +++           Y L+V V ++   G+P   +   +T+ + D N++ P 
Sbjct: 763  FDIELETGLLTVAAPLDYEATNFYILNVTVYDL---GTPQKSSWKLLTVNVKDWNDNAPR 819

Query: 353  FYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQT 412
            F     P   ++L+++E    G  +   ++T  D+D   N +    L+ P   F + P T
Sbjct: 820  F-----PPGGYQLTISEDTEVGTTIA--ELTTKDADSEDNGRVRYTLLSPTEKFSLHPLT 872

Query: 413  VLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP-EKFSSTADVVIQLLDTNDNVPK 471
               E  VT        +D E       K+ A +  +   +  S  D++I L D NDN P+
Sbjct: 873  --GELVVT------GHLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQ 924

Query: 472  FDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQ 531
              + +   ++PE+ P G+ +  + A DPD GP GEV+Y         F +   TG +  +
Sbjct: 925  CITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILE 984

Query: 532  PWASLDAEATARYNFYVKAED---MEGKYSVAEVFITLLDVND--HPPQFGKSVQ----K 582
                LD E  A YN  + A D      + ++  V + +LDVN+  HPP F   V     +
Sbjct: 985  --RELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQ 1042

Query: 583  KTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALH 642
            +    GT V + A  +D    +  + Y +        F IN  TG I    ++  LD   
Sbjct: 1043 ENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMI---QTLAPLD--- 1096

Query: 643  NITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDA 679
                     W L V A DRGS   S+   + I++TDA
Sbjct: 1097 --REFASYYW-LTVLAVDRGSVPLSSVTEVYIEVTDA 1130



 Score =  141 bits (355), Expect = 3e-33
 Identities = 158/621 (25%), Positives = 286/621 (46%), Gaps = 63/621 (10%)

Query: 97   DREREDEIEAIISISDGLN--LVAEKVV-ILVTDANDEAPRFIQEPYVALVPEDIPAGSI 153
            DRE++D  E  + + D      VA+ +V + + D ND  P+F   PY  ++ +    G +
Sbjct: 2029 DREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDV 2088

Query: 154  IFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
            +F+V A D D G+ G+VTY     ++ F +D + G + L+     DY+    +++ V+A+
Sbjct: 2089 LFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLK--KPFDYQALNKYHLKVIAR 2146

Query: 214  DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDG 273
            DGG           +   V V V +  +  P+F  +PY    Y+  +P +  L    +  
Sbjct: 2147 DGG------TPSLQSEEEVLVTVRNKSN--PLF-QSPY----YKVRVPENITLYTPILHT 2193

Query: 274  DRGKPN--RILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYELHV-QVTEMSPAG 329
                P   R++Y++V       F  +  +G +++T     L  E    HV  V     A 
Sbjct: 2194 QARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVT---GPLDYESKTKHVFTVRATDTAL 2250

Query: 330  SPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEH-PPQGEILRGLKITVNDSD 388
               ++ATV V +   D+N++PPTF      Q  +  S++E  P Q  +   +++  +D D
Sbjct: 2251 GSFSEATVEVLVE--DVNDNPPTF-----SQLVYTTSISEGLPAQTPV---IQLLASDQD 2300

Query: 389  QGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNT 448
             G N   + Q+V          Q   +  +++ + E    +D+E  +    K+ A++   
Sbjct: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE----LDYEAQQHFHVKVRAMDKGD 2356

Query: 449  PEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
            P     T  VV+ + D NDN P+F    Y A + E A  G  V+ V A+DPD+     ++
Sbjct: 2357 PPLTGETL-VVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLE 2415

Query: 509  YSTYGTGADL-FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLL 567
            Y       D  F I+ S+G+I    +        + YN  V A D   + +V  V+I   
Sbjct: 2416 YLILSGNQDRHFFINSSSGII--SMFNLCKKHLDSSYNLRVGASDGVFRATV-PVYINTT 2472

Query: 568  DVNDHPPQFGKSVQK----KTMVLGTPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
            + N + P+F + + +    +  ++GT V  + AID+D+  P   +DY+I +   +  F I
Sbjct: 2473 NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDS-GPYGTIDYTIINKLASEKFSI 2531

Query: 623  NSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS-PSFSTTALLKIDITDAET 681
            N + G+I    +++ LD  ++     + + +++V A+D G   +F T  ++  D  D   
Sbjct: 2532 NPN-GQI---ATLQKLDRENS----TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPP 2583

Query: 682  LSRSPMAAFLIQ---TKDNPM 699
              ++      IQ   +KD+P+
Sbjct: 2584 QFKASEYTVSIQSNVSKDSPV 2604



 Score =  140 bits (352), Expect = 7e-33
 Identities = 163/675 (24%), Positives = 290/675 (42%), Gaps = 78/675 (11%)

Query: 24   APHFFDNG-VGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFS 82
            AP F  +  VG  +    L+S+  D      V   + +D E + +  +   +P     F 
Sbjct: 1755 APMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFK 1814

Query: 83   VDPTFGNITLVEELDREREDEIEAIISISDGLNLV-----AEKVVILVTDANDEAPRFIQ 137
            +DP+ G +T+V E+D E     +  + + D  + V       +V+I V D ND  PRF +
Sbjct: 1815 IDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874

Query: 138  EPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRH--SGVLRLQAG 195
            + Y   +   I  G  +  V A D D+     V Y ++  ++  AV  H  +G + +   
Sbjct: 1875 QIYEVAIVGPIHPGMELLMVRASDEDS----EVNYSIKTGNADEAVTIHPVTGSISVLNP 1930

Query: 196  ATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYV 255
            A L   R     +T+ A DG         ++  T  V +++  V D +  F    Y+  V
Sbjct: 1931 AFLGLSRK----LTIRASDG---------LYQDTALVKISLTQVLDKSLQFDQDVYWAAV 1977

Query: 256  YEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV 315
             E+ L   + L ++   G+    + + Y L+NG D  F + +++G +  T+  A   RE 
Sbjct: 1978 KEN-LQDRKALVILGAQGNH-LNDTLSYFLLNGTD-MFHMVQSAGVLQ-TRGVA-FDREQ 2032

Query: 316  YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGE 375
             + H    E+    +P   A   V + I D+N++PP F         +   + +    G+
Sbjct: 2033 QDTHELAVEVRDNRTPQRVAQGLVRVSIEDVNDNPPKF-----KHLPYYTIIQDGTEPGD 2087

Query: 376  ILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSK 435
            +L   +++  D D G N     +       FR+ P   L +      +      D++   
Sbjct: 2088 VL--FQVSATDEDLGTNGAVTYEFAEDYTYFRIDP--YLGD------ISLKKPFDYQALN 2137

Query: 436  VLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVT 495
                K++A +  TP    S  +V++ +   N + P F S YY  R+PEN    + ++   
Sbjct: 2138 KYHLKVIARDGGTP-SLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPENITLYTPILHTQ 2194

Query: 496  AVDPDTGPWGEVKYSTYGTGAD----LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAE 551
            A  P      E     Y    +    LF     TG++       LD E+  ++ F V+A 
Sbjct: 2195 ARSP------EGLRLIYNIVEEEPLMLFTTDFKTGVLTVT--GPLDYESKTKHVFTVRAT 2246

Query: 552  DME-GKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNN 605
            D   G +S A V + + DVND+PP F + V   ++  G P     +++ A D+D+   N 
Sbjct: 2247 DTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGR-NR 2305

Query: 606  LVDYSITH--AEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
             V Y I    ++ +  F IN  TGE+   ++++ LD            + ++V+A D+G 
Sbjct: 2306 DVSYQIVEDGSDVSKFFQINGSTGEM---STVQELDY------EAQQHFHVKVRAMDKGD 2356

Query: 664  PSFSTTALLKIDITD 678
            P  +   L+ ++++D
Sbjct: 2357 PPLTGETLVVVNVSD 2371



 Score =  139 bits (349), Expect = 1e-32
 Identities = 149/607 (24%), Positives = 267/607 (43%), Gaps = 59/607 (9%)

Query: 43   SLPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
            S+ ED PVG+ V  L+  DP+      ++++I+   +    F + P  G ++  ++LDRE
Sbjct: 1145 SIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNIT-SGNYMGFFMIHPVTGLLSTAQQLDRE 1203

Query: 100  REDEIEAIISISDGLN---LVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGS--II 154
             +DE    +++ D          +VV+ + D ND  P F  + +   +PE +   S   +
Sbjct: 1204 NKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPV 1263

Query: 155  FKVHAVDRDTGSGGSVTYFLQNL-HSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
            +++ A D D G  G VTY +++     F++D  +GV+     ++  +     + +T+ A 
Sbjct: 1264 YRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVV----SSSSTFTAGEYNILTIKAT 1319

Query: 214  DGGGRLHGADVVFSATTTVTVNVEDV----QDMAPVFVGTPYYGYVYEDTLPGSEVLKVV 269
            D G            + +V +++E +        P+     YY +   +T P + ++ V+
Sbjct: 1320 DSGQP--------PLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVI 1371

Query: 270  AMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPA 328
            +++   G+P    +++  G+ D  F+I +T+G+I I +     +R  Y L V+VT+    
Sbjct: 1372 SVE---GRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTD---- 1424

Query: 329  GSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSD 388
            GS      V +   I ++N+H P F      + R+E+ + +    G  L  L++   D D
Sbjct: 1425 GSRTIATQVHI-FMIANINHHRPQFL-----ETRYEVRVPQDTVPGVEL--LRVQAIDQD 1476

Query: 389  QGANAKFNL---QLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVE 445
            +G +  + +   Q  G   +F++ P      + V + V             LT  +   E
Sbjct: 1477 KGKSLIYTIHGSQDPGSASLFQLDP-----SSGVLVTVGKLDLGSGPSQHTLTVMVRDQE 1531

Query: 446  VNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWG 505
            +     F     V I + D N + P+F  L+Y A +P+    G+ ++ V A+D D G   
Sbjct: 1532 IPIKRNF---VWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNA 1588

Query: 506  EVKYSTY-GTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGK--YSVAEV 562
            EV YS   G     F I+   G+I       LD    A +   VKAED      + +A V
Sbjct: 1589 EVHYSLLKGNSEGFFNINALLGIITLA--QKLDQANHAPHTLTVKAEDQGSPQWHDLATV 1646

Query: 563  FITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDI 622
             I +   +   P F KS     +    PV    +   A  P+  V Y +       VF +
Sbjct: 1647 IIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE-VTYELREGNKDGVFSM 1705

Query: 623  NSHTGEI 629
            NS++G I
Sbjct: 1706 NSYSGLI 1712



 Score =  116 bits (291), Expect = 8e-26
 Identities = 106/402 (26%), Positives = 173/402 (43%), Gaps = 31/402 (7%)

Query: 24   APHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPSTRSVFS 82
            AP FF +        +A+F   ++T V + V  +   DP+ G       S   S    FS
Sbjct: 3110 APRFFPSHCA-----VAVF---DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFS 3161

Query: 83   VDPTFGNITLVEELDREREDEIEAIISISD-GLNLVAEK---VVILVTDANDEAPRFIQE 138
            +D T G I L + L    +  +E  +  SD G  +       V + V    D  P F+  
Sbjct: 3162 IDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNT 3221

Query: 139  PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATL 198
             +   VPED P G+ + ++  + R             N    F +D  +G+L + A  +L
Sbjct: 3222 EHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGILYVNA--SL 3279

Query: 199  DYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYED 258
            D+E S  +++++           +    S  TTV VN+ DV +  P F   PY   V E+
Sbjct: 3280 DFETSPKYFLSIECS------RKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLEN 3333

Query: 259  TLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITQSPAQLQREVYE 317
             L G  +L V A D D    + I YSL+ GN  G F I+   G + + ++  + Q   Y 
Sbjct: 3334 ALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYS 3393

Query: 318  LHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEIL 377
            L ++ T+   +G P       + I++ D+N++PP F+     Q  +  ++ E+ P G  +
Sbjct: 3394 LKLRATD---SGQPPLHEDTDIAIQVADVNDNPPRFF-----QLNYSTTVQENSPIGSKV 3445

Query: 378  RGLKITVNDS-DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQ 418
              L ++  DS + G    F +        FRV P   L  A+
Sbjct: 3446 LQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAE 3487



 Score =  100 bits (248), Expect = 8e-21
 Identities = 144/625 (23%), Positives = 242/625 (38%), Gaps = 123/625 (19%)

Query: 96  LDREREDEIEAIISISDG-LNLVA-EKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSI 153
           L+RE  D    II  ++  L L A  +VV+ + D ND  P F    Y   + ED+P  S 
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166

Query: 154 IFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAK 213
           I KV A D D G      Y        FA+   SGV+ +     + +     H + V+A 
Sbjct: 167 ICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGK--HELQVLAV 224

Query: 214 DGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFV-----------GTPYYGYVYEDTLPG 262
           D   ++   +  F +   + V+VE      P              GT Y   + +    G
Sbjct: 225 DRMRKISEGN-GFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSG 283

Query: 263 SEVLKVVAMDGDRGKPNRILYSLVNGNDG-------------------AFEINETSGAIS 303
           +EV  V  + GD GK  + + S    N+                    + +    SG   
Sbjct: 284 AEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYF 343

Query: 304 ITQ------SPAQLQREVYE---LHVQVTEMSPAGS--------PA-------------- 332
            +Q       P++L    +E     VQ++E SP GS        PA              
Sbjct: 344 YSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSEN 403

Query: 333 ------AQATVPVTIRIVDLNN------HPPTFYGESGP-----------------QNRF 363
                 A+  +  T +++D ++      H  T  G++                   ++ +
Sbjct: 404 VGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTVVVIDIVDCNNHAPLFNRSSY 463

Query: 364 ELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGI-FRVVPQTVLNEAQVTII 422
           + +++E+ P G  +  L +T  D D G N      + GP+ + F + P           I
Sbjct: 464 DGTLDENIPPGTSV--LAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLG--------I 513

Query: 423 VENSAAIDFEKSK-VLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARI 481
           +  S  +D+E  K + TF++ A +  +P +      + +QL + NDN P F+ +     I
Sbjct: 514 ISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSI 573

Query: 482 PENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLI-YTQPWASLDAE 539
            ++ P G S++ ++A+D D      +KY    G   + F ++  +G+I   +P+ +L A 
Sbjct: 574 RQDWPVGKSIMTMSAIDVD--ELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAG 631

Query: 540 ATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQ-KKTMVLGTPVK------ 592
               Y+  + A D  GK   +   + +  V D  P F   V   KT VL    K      
Sbjct: 632 QPTSYSLKITASD--GKNYASPTTLNITVVKD--PHFEVPVTCDKTGVLTQFTKTILHFI 687

Query: 593 -IEAIDEDAEEPNNLVDYSITHAEP 616
            ++  +   EE  +L  Y I H  P
Sbjct: 688 GLQNQESSDEEFTSLSTYQINHYTP 712



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 143/538 (26%), Positives = 216/538 (40%), Gaps = 110/538 (20%)

Query: 228 ATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVN 287
           A T V V++ D  D+ P+F    Y   + ED    S + KV A D D G+ N   Y   N
Sbjct: 130 ALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQ-NAEFYYAFN 188

Query: 288 GNDGAFEINET------SGAISIT-QSPAQLQ-------REVYE------LHVQVTEMSP 327
                F I+ T      +G +++T +   +LQ       R++ E      L   V  + P
Sbjct: 189 TRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEP 248

Query: 328 A-GSPAAQATVPVT-----------IRIVDLNNHPPTFY------GESGPQ--------- 360
           A   P A A+V VT             +VD N+            G+ G           
Sbjct: 249 ALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYAR 308

Query: 361 -NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVG-------------PRGIF 406
            N F L   +     E L G  +++  +  G+   F  Q+ G              + ++
Sbjct: 309 SNEFSLVSVKDINWMEYLHGFNLSLQ-ARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVY 367

Query: 407 RVV------PQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA----------------- 443
           RV       P + +   +VT    N   +    S+ + FKL A                 
Sbjct: 368 RVQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRA 427

Query: 444 ---VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPD 500
              + + T    +ST  VVI ++D N++ P F+   Y   + EN P G+SV+AVTA D D
Sbjct: 428 HYQLHIRTSPGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD 486

Query: 501 TGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATAR-YNFYVKAEDMEGKY-- 557
            G  G V YS  G  A  F I P  G+I T     +D E   R Y F V+A D    +  
Sbjct: 487 HGENGYVTYSIAGPKALPFSIDPYLGIISTS--KPMDYELMKRIYTFRVRASDWGSPFRR 544

Query: 558 -SVAEVFITLLDVNDHPPQFGK-----SVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 611
                +F+ L ++ND+ P F +     S+++   V  + + + AID D  E  NL  Y I
Sbjct: 545 EKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNL-KYEI 601

Query: 612 THAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTT 669
                   FD+N  +G I LK          N+T G+   +SL++ A D  + +  TT
Sbjct: 602 VSGNELEYFDLNHFSGVISLKR------PFINLTAGQPTSYSLKITASDGKNYASPTT 653



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 61/251 (24%), Positives = 106/251 (42%), Gaps = 19/251 (7%)

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
           N+A ++ E     T  + A E     +  +   VV+ +LD ND  P F    Y   I E+
Sbjct: 103 NTALLNREVRDSYTLIIQATEKTL--ELEALTRVVVHILDQNDLKPLFSPPSYRVTISED 160

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P  S +  VTA D D G   E  Y+ + T +++F IHP++G++       L+     ++
Sbjct: 161 MPLKSPICKVTATDADLGQNAEFYYA-FNTRSEMFAIHPTSGVVTVA--GKLNVTWRGKH 217

Query: 545 NFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPN 604
              V A D   K S    F +L  +  H      +++K   +    V     ++      
Sbjct: 218 ELQVLAVDRMRKISEGNGFGSLAALVVH---VEPALRKPPAIASVVVTPPDSNDGTTYAT 274

Query: 605 NLVDYSITHAEPANVFDINSHTGEIW--LKNSIRSLDALHNITPGRDCLW-------SLE 655
            LVD + + AE  +V  +    G+ +  +K+  RS +   ++   +D  W       +L 
Sbjct: 275 VLVDANSSGAEVESVEVVGGDPGKHFKAIKSYARSNE--FSLVSVKDINWMEYLHGFNLS 332

Query: 656 VQAKDRGSPSF 666
           +QA+    P F
Sbjct: 333 LQARSGSGPYF 343



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 70/283 (24%), Positives = 110/283 (38%), Gaps = 44/283 (15%)

Query: 246 FVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPN-RILYSLVNGN-DGAFEINE-TSGAI 302
           F  + Y   +YE++ P + V     M     +P   + Y +++G+    F+  E   G  
Sbjct: 33  FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92

Query: 303 SI------TQSPAQLQREV---YELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTF 353
                   + + A L REV   Y L +Q TE +       +A   V + I+D N+  P F
Sbjct: 93  CFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE----LEALTRVVVHILDQNDLKPLF 148

Query: 354 YGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQ-- 411
              S P  R  +S  + P +  I    K+T  D+D G NA+F         +F + P   
Sbjct: 149 ---SPPSYRVTIS-EDMPLKSPIC---KVTATDADLGQNAEFYYAFNTRSEMFAIHPTSG 201

Query: 412 --TVLNEAQVT---------IIVENSAAIDFEKSKVLTFKLLAVEVNTP-EKFSSTADVV 459
             TV  +  VT         + V+    I  E +   +   L V V     K  + A VV
Sbjct: 202 VVTVAGKLNVTWRGKHELQVLAVDRMRKIS-EGNGFGSLAALVVHVEPALRKPPAIASVV 260

Query: 460 IQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTG 502
           +   D+ND         Y   + +    G+ V +V  V  D G
Sbjct: 261 VTPPDSNDGTT------YATVLVDANSSGAEVESVEVVGGDPG 297


>gi|11056030 protocadherin gamma subfamily A, 2 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  186 bits (471), Expect = 1e-46
 Identities = 176/631 (27%), Positives = 271/631 (42%), Gaps = 70/631 (11%)

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGL----NLVAEKVVILVTDANDEAPRF 135
           +F+++P  G++     +DRE      A   ++  +     L    V + +TD ND APRF
Sbjct: 74  LFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEITDINDNAPRF 133

Query: 136 IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV-----L 190
             E     + E    G  I   +A D D G      Y L N +  F++D   G       
Sbjct: 134 GVEELELKISETTTPGFRIPLKNAHDADVGENALQKYAL-NPNDHFSLDVRRGADGNKYP 192

Query: 191 RLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTP 250
            L    +LD E    H++ +VA DGG      D V S T+ + V V D  D APVF    
Sbjct: 193 ELVLERSLDREEEAVHHLVLVASDGG------DPVLSGTSRICVKVLDANDNAPVFTQPE 246

Query: 251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNG---NDGAFEINETSGAISITQS 307
           Y   + E+TL G+ +L V A D D G   +++Y L          FE+  TSG ++I + 
Sbjct: 247 YRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKD 306

Query: 308 PAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSM 367
                   +E+ ++  +      P       V + ++D+N++ P FY  S        S+
Sbjct: 307 LDYEDATFHEIDIEAQD-----GPGLLTRAKVIVTVLDVNDNAPEFYMTSATS-----SV 356

Query: 368 NEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSA 427
           +E    G I+ GL   V+D D G NA     L  P  +   + ++V N  ++      + 
Sbjct: 357 SEDSLPGTII-GL-FNVHDRDSGQNAFTTCSL--PEDLPFKLEKSVDNYYRLV----TTR 408

Query: 428 AIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPG 487
           A+D E+       L A +   P   S+ A +++Q+ D NDN P F    Y   IPEN P 
Sbjct: 409 ALDREQFSFYNITLTAKDGGNPS-LSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPR 467

Query: 488 GSSVVAVTAVDPDTGPWGEVKYS-----TYGTGADLFL-IHPSTGLIYTQPWASLDAEAT 541
           G+SV +VTA DPD+     V YS       G     ++ I+  TG++Y     S D E  
Sbjct: 468 GASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYA--LRSFDYEQL 525

Query: 542 ARYNFYVKAEDMEGKYSVAEVFITL--LDVNDHPPQF-----------GKSVQKKTMVLG 588
                +V A D       + V ++L  LD ND+ P+            G  +  ++   G
Sbjct: 526 RDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEPG 585

Query: 589 TPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPG 647
             V K+ A+D D+ + N  + Y +  A    +F +  HTGE+    ++   DAL      
Sbjct: 586 YLVTKVVAVDRDSGQ-NAWLSYHLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ---- 640

Query: 648 RDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
                SL V  +D G P  S T  L + + D
Sbjct: 641 -----SLVVAIQDHGQPPLSATVTLTVAVAD 666



 Score =  119 bits (297), Expect = 2e-26
 Identities = 106/381 (27%), Positives = 165/381 (43%), Gaps = 26/381 (6%)

Query: 43  SLPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPS-TRSVFSVDPTFGNITLVEELDR 98
           S+PE+T VG+ + T+  TD +      + Y +   P  T  VF +  T G +T++++LD 
Sbjct: 250 SIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKDLDY 309

Query: 99  EREDEIEAIISISDGLNLVAE-KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
           E     E  I   DG  L+   KV++ V D ND AP F      + V ED   G+II   
Sbjct: 310 EDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLF 369

Query: 158 HAVDRDTGSGGSVTYFLQNLHSPFAVDRH-SGVLRLQAGATLDYERSRTHYITVVAKDGG 216
           +  DRD+G     T  L     PF +++      RL     LD E+   + IT+ AKDGG
Sbjct: 370 NVHDRDSGQNAFTTCSLPE-DLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGG 428

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                 +   S    + + V D+ D AP F  T Y  Y+ E+   G+ V  V A D D  
Sbjct: 429 ------NPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSN 482

Query: 277 KPNRILYSLVNGN-DGA-----FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGS 330
               + YS       GA       IN  +G +   +S    Q    ++ V   +   +G+
Sbjct: 483 DNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARD---SGN 539

Query: 331 PAAQATVPVTIRIVDLNNHPPTFYGESGP---QNRFELSMNEHPPQGEILRGLKITVNDS 387
           P   + V +++ ++D N++ P     + P       EL+     P G ++  +     DS
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEP-GYLVTKVVAVDRDS 598

Query: 388 DQGANAKFNLQLVGPRGIFRV 408
            Q A   ++L      G+F V
Sbjct: 599 GQNAWLSYHLLKASEPGLFSV 619


>gi|14196462 protocadherin gamma subfamily A, 2 isoform 2 precursor
           [Homo sapiens]
          Length = 823

 Score =  186 bits (471), Expect = 1e-46
 Identities = 176/631 (27%), Positives = 271/631 (42%), Gaps = 70/631 (11%)

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGL----NLVAEKVVILVTDANDEAPRF 135
           +F+++P  G++     +DRE      A   ++  +     L    V + +TD ND APRF
Sbjct: 74  LFALNPRSGSLVTANRIDREELCAQSAPCLLNFNILLEDKLTIYSVEVEITDINDNAPRF 133

Query: 136 IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV-----L 190
             E     + E    G  I   +A D D G      Y L N +  F++D   G       
Sbjct: 134 GVEELELKISETTTPGFRIPLKNAHDADVGENALQKYAL-NPNDHFSLDVRRGADGNKYP 192

Query: 191 RLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTP 250
            L    +LD E    H++ +VA DGG      D V S T+ + V V D  D APVF    
Sbjct: 193 ELVLERSLDREEEAVHHLVLVASDGG------DPVLSGTSRICVKVLDANDNAPVFTQPE 246

Query: 251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNG---NDGAFEINETSGAISITQS 307
           Y   + E+TL G+ +L V A D D G   +++Y L          FE+  TSG ++I + 
Sbjct: 247 YRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKD 306

Query: 308 PAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSM 367
                   +E+ ++  +      P       V + ++D+N++ P FY  S        S+
Sbjct: 307 LDYEDATFHEIDIEAQD-----GPGLLTRAKVIVTVLDVNDNAPEFYMTSATS-----SV 356

Query: 368 NEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSA 427
           +E    G I+ GL   V+D D G NA     L  P  +   + ++V N  ++      + 
Sbjct: 357 SEDSLPGTII-GL-FNVHDRDSGQNAFTTCSL--PEDLPFKLEKSVDNYYRLV----TTR 408

Query: 428 AIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPG 487
           A+D E+       L A +   P   S+ A +++Q+ D NDN P F    Y   IPEN P 
Sbjct: 409 ALDREQFSFYNITLTAKDGGNPS-LSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPR 467

Query: 488 GSSVVAVTAVDPDTGPWGEVKYS-----TYGTGADLFL-IHPSTGLIYTQPWASLDAEAT 541
           G+SV +VTA DPD+     V YS       G     ++ I+  TG++Y     S D E  
Sbjct: 468 GASVFSVTAHDPDSNDNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYA--LRSFDYEQL 525

Query: 542 ARYNFYVKAEDMEGKYSVAEVFITL--LDVNDHPPQF-----------GKSVQKKTMVLG 588
                +V A D       + V ++L  LD ND+ P+            G  +  ++   G
Sbjct: 526 RDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEPG 585

Query: 589 TPV-KIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPG 647
             V K+ A+D D+ + N  + Y +  A    +F +  HTGE+    ++   DAL      
Sbjct: 586 YLVTKVVAVDRDSGQ-NAWLSYHLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ---- 640

Query: 648 RDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
                SL V  +D G P  S T  L + + D
Sbjct: 641 -----SLVVAIQDHGQPPLSATVTLTVAVAD 666



 Score =  119 bits (297), Expect = 2e-26
 Identities = 106/381 (27%), Positives = 165/381 (43%), Gaps = 26/381 (6%)

Query: 43  SLPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPS-TRSVFSVDPTFGNITLVEELDR 98
           S+PE+T VG+ + T+  TD +      + Y +   P  T  VF +  T G +T++++LD 
Sbjct: 250 SIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKDLDY 309

Query: 99  EREDEIEAIISISDGLNLVAE-KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKV 157
           E     E  I   DG  L+   KV++ V D ND AP F      + V ED   G+II   
Sbjct: 310 EDATFHEIDIEAQDGPGLLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLF 369

Query: 158 HAVDRDTGSGGSVTYFLQNLHSPFAVDRH-SGVLRLQAGATLDYERSRTHYITVVAKDGG 216
           +  DRD+G     T  L     PF +++      RL     LD E+   + IT+ AKDGG
Sbjct: 370 NVHDRDSGQNAFTTCSLPE-DLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGG 428

Query: 217 GRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG 276
                 +   S    + + V D+ D AP F  T Y  Y+ E+   G+ V  V A D D  
Sbjct: 429 ------NPSLSTDAHILLQVADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSN 482

Query: 277 KPNRILYSLVNGN-DGA-----FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGS 330
               + YS       GA       IN  +G +   +S    Q    ++ V   +   +G+
Sbjct: 483 DNAHVTYSFAEDTVQGAPLSSYISINSDTGVLYALRSFDYEQLRDLQVWVIARD---SGN 539

Query: 331 PAAQATVPVTIRIVDLNNHPPTFYGESGP---QNRFELSMNEHPPQGEILRGLKITVNDS 387
           P   + V +++ ++D N++ P     + P       EL+     P G ++  +     DS
Sbjct: 540 PPLSSNVSLSLFVLDQNDNAPEILYPAFPTDGSTGVELAPRSAEP-GYLVTKVVAVDRDS 598

Query: 388 DQGANAKFNLQLVGPRGIFRV 408
            Q A   ++L      G+F V
Sbjct: 599 GQNAWLSYHLLKASEPGLFSV 619


>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
           sapiens]
          Length = 1021

 Score =  179 bits (454), Expect = 1e-44
 Identities = 174/587 (29%), Positives = 265/587 (45%), Gaps = 57/587 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 417

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG ++ KV AMD D G   +I Y L       F ++  +G +++ +   +L
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KL 528

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N +   + E+ 
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYNFYVPENL 583

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 584 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 633

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF----DSLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 634 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG 692

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 693 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 749

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND---HPPQFGKSVQKKTMVLGTP 590
            VKA D+    S+  V I  L VN+   +     + V+K T    TP
Sbjct: 750 LVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796



 Score =  171 bits (434), Expect = 2e-42
 Identities = 209/805 (25%), Positives = 331/805 (41%), Gaps = 121/805 (15%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 313 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 361

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 419

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 474

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLN--EAQVTIIVE 424
           + E+   G  ++  K++  D+D G NAK N  L+GP       P+  L+     +T++ +
Sbjct: 475 IPENNSPG--IQLTKVSAMDADSGPNAKINY-LLGPDA----PPEFSLDCRTGMLTVVKK 527

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
               +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN
Sbjct: 528 ----LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P   +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESY 639

Query: 545 NFYVKAED--MEGKYSVAEVFITLLDVNDHPPQF--GKSVQKKTMVL-----GTPV-KIE 594
            FYVKAED     + S A+V I ++DVND+ P F    S     +VL     GT V ++ 
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI 699

Query: 595 AIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWS 653
           A+D D    N  V YSI      ++F I+  TG I L       D  LH +         
Sbjct: 700 AVDNDTGM-NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-------- 750

Query: 654 LEVQAKDRGSPS--FS------------TTALLKIDI----TDAETLSRSPMAAFLIQTK 695
             V+A D G P   FS            T A L  ++    T+A     + +A     T 
Sbjct: 751 --VKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTS 808

Query: 696 DNPMKAVGVLAGTMATVVAITVLI--------STATFWRNKKS---------NKVLPMRR 738
           D     V  +AGT+  VV I +                +NK++         N+ + M +
Sbjct: 809 DYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMK 868

Query: 739 VLRKRPSPAPRTIRIEWLKSKSTKA 763
             +K+   +P+ + + ++  + TKA
Sbjct: 869 KKKKKKKHSPKNLLLNFVTIEETKA 893



 Score =  135 bits (341), Expect = 1e-31
 Identities = 169/630 (26%), Positives = 265/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 75  IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 132

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 246

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 307 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 361

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 362 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 415

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++E +A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 416 ---FLLETAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  +  V+A+D D+GP  ++ Y         F +   TG++       LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK--KLD 529

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 530 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 590 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 635

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 665


>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
          Length = 1337

 Score =  179 bits (454), Expect = 1e-44
 Identities = 174/587 (29%), Positives = 265/587 (45%), Gaps = 57/587 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 417

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG ++ KV AMD D G   +I Y L       F ++  +G +++ +   +L
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KL 528

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N +   + E+ 
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYNFYVPENL 583

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 584 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 633

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF----DSLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 634 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG 692

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 693 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 749

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND---HPPQFGKSVQKKTMVLGTP 590
            VKA D+    S+  V I  L VN+   +     + V+K T    TP
Sbjct: 750 LVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796



 Score =  171 bits (434), Expect = 2e-42
 Identities = 209/805 (25%), Positives = 331/805 (41%), Gaps = 121/805 (15%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 313 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 361

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 419

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 474

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLN--EAQVTIIVE 424
           + E+   G  ++  K++  D+D G NAK N  L+GP       P+  L+     +T++ +
Sbjct: 475 IPENNSPG--IQLTKVSAMDADSGPNAKINY-LLGPDA----PPEFSLDCRTGMLTVVKK 527

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
               +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN
Sbjct: 528 ----LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P   +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESY 639

Query: 545 NFYVKAED--MEGKYSVAEVFITLLDVNDHPPQF--GKSVQKKTMVL-----GTPV-KIE 594
            FYVKAED     + S A+V I ++DVND+ P F    S     +VL     GT V ++ 
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI 699

Query: 595 AIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWS 653
           A+D D    N  V YSI      ++F I+  TG I L       D  LH +         
Sbjct: 700 AVDNDTGM-NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-------- 750

Query: 654 LEVQAKDRGSPS--FS------------TTALLKIDI----TDAETLSRSPMAAFLIQTK 695
             V+A D G P   FS            T A L  ++    T+A     + +A     T 
Sbjct: 751 --VKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTS 808

Query: 696 DNPMKAVGVLAGTMATVVAITVLI--------STATFWRNKKS---------NKVLPMRR 738
           D     V  +AGT+  VV I +                +NK++         N+ + M +
Sbjct: 809 DYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMK 868

Query: 739 VLRKRPSPAPRTIRIEWLKSKSTKA 763
             +K+   +P+ + + ++  + TKA
Sbjct: 869 KKKKKKKHSPKNLLLNFVTIEETKA 893



 Score =  135 bits (341), Expect = 1e-31
 Identities = 169/630 (26%), Positives = 265/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 75  IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 132

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 246

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 307 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 361

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 362 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 415

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++E +A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 416 ---FLLETAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  +  V+A+D D+GP  ++ Y         F +   TG++       LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK--KLD 529

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 530 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 590 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 635

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 665


>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
          Length = 1347

 Score =  179 bits (454), Expect = 1e-44
 Identities = 174/587 (29%), Positives = 265/587 (45%), Gaps = 57/587 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 417

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG ++ KV AMD D G   +I Y L       F ++  +G +++ +   +L
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KL 528

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N +   + E+ 
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYNFYVPENL 583

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 584 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 633

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF----DSLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 634 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG 692

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 693 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 749

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND---HPPQFGKSVQKKTMVLGTP 590
            VKA D+    S+  V I  L VN+   +     + V+K T    TP
Sbjct: 750 LVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796



 Score =  171 bits (434), Expect = 2e-42
 Identities = 209/805 (25%), Positives = 331/805 (41%), Gaps = 121/805 (15%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 313 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 361

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 419

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 474

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLN--EAQVTIIVE 424
           + E+   G  ++  K++  D+D G NAK N  L+GP       P+  L+     +T++ +
Sbjct: 475 IPENNSPG--IQLTKVSAMDADSGPNAKINY-LLGPDA----PPEFSLDCRTGMLTVVKK 527

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
               +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN
Sbjct: 528 ----LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P   +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESY 639

Query: 545 NFYVKAED--MEGKYSVAEVFITLLDVNDHPPQF--GKSVQKKTMVL-----GTPV-KIE 594
            FYVKAED     + S A+V I ++DVND+ P F    S     +VL     GT V ++ 
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI 699

Query: 595 AIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWS 653
           A+D D    N  V YSI      ++F I+  TG I L       D  LH +         
Sbjct: 700 AVDNDTGM-NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-------- 750

Query: 654 LEVQAKDRGSPS--FS------------TTALLKIDI----TDAETLSRSPMAAFLIQTK 695
             V+A D G P   FS            T A L  ++    T+A     + +A     T 
Sbjct: 751 --VKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTS 808

Query: 696 DNPMKAVGVLAGTMATVVAITVLI--------STATFWRNKKS---------NKVLPMRR 738
           D     V  +AGT+  VV I +                +NK++         N+ + M +
Sbjct: 809 DYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMK 868

Query: 739 VLRKRPSPAPRTIRIEWLKSKSTKA 763
             +K+   +P+ + + ++  + TKA
Sbjct: 869 KKKKKKKHSPKNLLLNFVTIEETKA 893



 Score =  135 bits (341), Expect = 1e-31
 Identities = 169/630 (26%), Positives = 265/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 75  IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 132

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 246

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 307 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 361

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 362 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 415

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++E +A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 416 ---FLLETAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  +  V+A+D D+GP  ++ Y         F +   TG++       LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK--KLD 529

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 530 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 590 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 635

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 665


>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
           sapiens]
          Length = 1025

 Score =  179 bits (454), Expect = 1e-44
 Identities = 174/587 (29%), Positives = 265/587 (45%), Gaps = 57/587 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 239 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 358

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 417

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 418 LETAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG ++ KV AMD D G   +I Y L       F ++  +G +++ +   +L
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK---KL 528

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N +   + E+ 
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYNFYVPENL 583

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 584 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 633

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF----DSLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 634 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPG 692

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 693 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 749

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND---HPPQFGKSVQKKTMVLGTP 590
            VKA D+    S+  V I  L VN+   +     + V+K T    TP
Sbjct: 750 LVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTP 796



 Score =  171 bits (434), Expect = 2e-42
 Identities = 209/805 (25%), Positives = 331/805 (41%), Gaps = 121/805 (15%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 252

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 253 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 313 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 361

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 362 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 419

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 420 TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 474

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLN--EAQVTIIVE 424
           + E+   G  ++  K++  D+D G NAK N  L+GP       P+  L+     +T++ +
Sbjct: 475 IPENNSPG--IQLTKVSAMDADSGPNAKINY-LLGPDA----PPEFSLDCRTGMLTVVKK 527

Query: 425 NSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPEN 484
               +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN
Sbjct: 528 ----LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPEN 582

Query: 485 APGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARY 544
            P   +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y
Sbjct: 583 LPRHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESY 639

Query: 545 NFYVKAED--MEGKYSVAEVFITLLDVNDHPPQF--GKSVQKKTMVL-----GTPV-KIE 594
            FYVKAED     + S A+V I ++DVND+ P F    S     +VL     GT V ++ 
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVI 699

Query: 595 AIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWS 653
           A+D D    N  V YSI      ++F I+  TG I L       D  LH +         
Sbjct: 700 AVDNDTGM-NAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL-------- 750

Query: 654 LEVQAKDRGSPS--FS------------TTALLKIDI----TDAETLSRSPMAAFLIQTK 695
             V+A D G P   FS            T A L  ++    T+A     + +A     T 
Sbjct: 751 --VKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTS 808

Query: 696 DNPMKAVGVLAGTMATVVAITVLI--------STATFWRNKKS---------NKVLPMRR 738
           D     V  +AGT+  VV I +                +NK++         N+ + M +
Sbjct: 809 DYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMK 868

Query: 739 VLRKRPSPAPRTIRIEWLKSKSTKA 763
             +K+   +P+ + + ++  + TKA
Sbjct: 869 KKKKKKKHSPKNLLLNFVTIEETKA 893



 Score =  135 bits (341), Expect = 1e-31
 Identities = 169/630 (26%), Positives = 265/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 75  IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 132

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 133 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 192

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 193 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 246

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 247 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 306

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 307 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 361

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 362 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 415

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++E +A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 416 ---FLLETAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 471

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  +  V+A+D D+GP  ++ Y         F +   TG++       LD
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVK--KLD 529

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 530 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 590 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 635

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 665


>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
          Length = 1340

 Score =  177 bits (448), Expect = 5e-44
 Identities = 168/565 (29%), Positives = 257/565 (45%), Gaps = 54/565 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 449

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG +++KV A D D G    I Y L       F ++  +G +++ +   +L
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KL 560

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N ++  + E+ 
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYKFYVPENL 615

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 616 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 665

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFD----SLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 666 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 725 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 781

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND 571
            VKA D+    S+  V I  L VN+
Sbjct: 782 LVKANDLGQPDSLFSVVIVNLFVNE 806



 Score =  169 bits (428), Expect = 1e-41
 Identities = 198/786 (25%), Positives = 317/786 (40%), Gaps = 104/786 (13%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 224

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 284

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 285 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 345 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 393

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 394 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 451

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 506

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENS 426
           + E+   G  ++ +K++  D+D G NA+ N  L+GP       P+  L+     + V   
Sbjct: 507 IPENNSPG--IQLMKVSATDADSGPNAEINY-LLGPDA----PPEFSLDRRTGMLTVVKK 559

Query: 427 AAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAP 486
             +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN P
Sbjct: 560 --LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP 616

Query: 487 GGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNF 546
              +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y F
Sbjct: 617 RHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESYTF 673

Query: 547 YVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP--------VKIEAI 596
           YVKAED     + S A+V I ++DVND+ P F       +  L  P         ++ A+
Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733

Query: 597 DEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWSLE 655
           D D    N  V YSI      ++F I+  TG I L       D  LH +           
Sbjct: 734 DNDT-GMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL---------- 782

Query: 656 VQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQ-------------------TKD 696
           V+A D G P  S  +++ +++   E+++ + +   L++                   T D
Sbjct: 783 VKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841

Query: 697 NPMKAVGVLAGTMATVVAITVLISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWL 756
                V  +AGT+  VV I   I+     R     K         +  +P P   ++  +
Sbjct: 842 YVKILVAAVAGTITVVVVI--FITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMM 899

Query: 757 KSKSTK 762
           K K  K
Sbjct: 900 KKKKKK 905



 Score =  140 bits (352), Expect = 7e-33
 Identities = 171/630 (27%), Positives = 266/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 107 IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 164

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 224

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 278

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 339 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 393

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 394 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 447

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++EN+A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 448 ---FLLENAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  ++ V+A D D+GP  E+ Y         F +   TG++       LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK--KLD 561

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 562 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 622 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 667

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 697


>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
          Length = 1048

 Score =  177 bits (448), Expect = 5e-44
 Identities = 168/565 (29%), Positives = 257/565 (45%), Gaps = 54/565 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 271 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 390

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 391 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 449

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 450 LENAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG +++KV A D D G    I Y L       F ++  +G +++ +   +L
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KL 560

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N ++  + E+ 
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYKFYVPENL 615

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 616 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 665

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFD----SLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 666 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 724

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 725 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 781

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND 571
            VKA D+    S+  V I  L VN+
Sbjct: 782 LVKANDLGQPDSLFSVVIVNLFVNE 806



 Score =  169 bits (428), Expect = 1e-41
 Identities = 198/786 (25%), Positives = 317/786 (40%), Gaps = 104/786 (13%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 224

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 284

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 285 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 345 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 393

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 394 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 451

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 452 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 506

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENS 426
           + E+   G  ++ +K++  D+D G NA+ N  L+GP       P+  L+     + V   
Sbjct: 507 IPENNSPG--IQLMKVSATDADSGPNAEINY-LLGPDA----PPEFSLDRRTGMLTVVKK 559

Query: 427 AAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAP 486
             +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN P
Sbjct: 560 --LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP 616

Query: 487 GGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNF 546
              +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y F
Sbjct: 617 RHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESYTF 673

Query: 547 YVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP--------VKIEAI 596
           YVKAED     + S A+V I ++DVND+ P F       +  L  P         ++ A+
Sbjct: 674 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733

Query: 597 DEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWSLE 655
           D D    N  V YSI      ++F I+  TG I L       D  LH +           
Sbjct: 734 DNDT-GMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL---------- 782

Query: 656 VQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQ-------------------TKD 696
           V+A D G P  S  +++ +++   E+++ + +   L++                   T D
Sbjct: 783 VKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 841

Query: 697 NPMKAVGVLAGTMATVVAITVLISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWL 756
                V  +AGT+  VV I   I+     R     K         +  +P P   ++  +
Sbjct: 842 YVKILVAAVAGTITVVVVI--FITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMM 899

Query: 757 KSKSTK 762
           K K  K
Sbjct: 900 KKKKKK 905



 Score =  140 bits (352), Expect = 7e-33
 Identities = 171/630 (27%), Positives = 266/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 107 IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 164

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 165 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 224

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 225 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 278

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 279 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 338

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 339 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 393

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 394 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 447

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++EN+A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 448 ---FLLENAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 503

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  ++ V+A D D+GP  E+ Y         F +   TG++       LD
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK--KLD 561

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 562 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 622 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 667

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 668 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 697


>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
          Length = 1037

 Score =  177 bits (448), Expect = 5e-44
 Identities = 168/565 (29%), Positives = 257/565 (45%), Gaps = 54/565 (9%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPE-GDPISYHISFDPST----RS 79
           V  TN N  +F       S+PE+ PVG+ V  L+ TD + G+    H SF        R 
Sbjct: 260 VTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319

Query: 80  VFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL-VTDANDEAP----R 134
           +F ++ T G IT+ E LDRE     + ++  SDG  + A  +V++ VTD ND  P    R
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR 379

Query: 135 FIQEPY--VALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDR-HSGVLR 191
           +I  P     ++ E+IP  + I  +   D+D    G VT F  +   PF +    S    
Sbjct: 380 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDH-EIPFRLRPVFSNQFL 438

Query: 192 LQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPY 251
           L+  A LDYE ++ + I ++A D G          + +  + + V+D  D APVF  +  
Sbjct: 439 LENAAYLDYESTKEYAIKLLAADAG------KPPLNQSAMLFIKVKDENDNAPVFTQSFV 492

Query: 252 YGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQL 311
              + E+  PG +++KV A D D G    I Y L       F ++  +G +++ +   +L
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK---KL 549

Query: 312 QREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHP 371
            RE  + ++        G P   + V V + I+D N++ P F       N ++  + E+ 
Sbjct: 550 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVF-----THNEYKFYVPENL 604

Query: 372 PQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDF 431
           P+   + GL ITV D D G N+   L ++     F +  QT         ++  + + D 
Sbjct: 605 PRHGTV-GL-ITVTDPDYGDNSAVTLSILDENDDFTIDSQTG--------VIRPNISFDR 654

Query: 432 EKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFD----SLYYVARIPENAPG 487
           EK +  TF + A +     + SS+A V I ++D NDN P F     +  Y   +P   PG
Sbjct: 655 EKQESYTFYVKAEDGGRVSR-SSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPG 713

Query: 488 GSSVVAVTAVDPDTGPWGEVKYSTYGTGA-DLFLIHPSTGLIYTQPWASLDAEATARYNF 546
            + V  V AVD DTG   EV+YS  G    DLF I   TG I        D      +  
Sbjct: 714 -TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRV 770

Query: 547 YVKAEDMEGKYSVAEVFITLLDVND 571
            VKA D+    S+  V I  L VN+
Sbjct: 771 LVKANDLGQPDSLFSVVIVNLFVNE 795



 Score =  169 bits (428), Expect = 1e-41
 Identities = 198/786 (25%), Positives = 317/786 (40%), Gaps = 104/786 (13%)

Query: 36  NGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD---- 84
           N N  LF       S+PE++ + S        DP+             ++++F +D    
Sbjct: 154 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 213

Query: 85  ---PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPRFIQE 138
                   + + +ELDRE +D     + + DG         IL   VTD ND  P F + 
Sbjct: 214 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKET 273

Query: 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFA-----VDRHSGVLRLQ 193
                +PE+ P G+ + ++HA D D G    + +   NL S  A     ++  +G++ ++
Sbjct: 274 EIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 333

Query: 194 AGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG 253
               LD E +  H + V+A DGG        +  A   V VNV DV D  P  +   Y  
Sbjct: 334 E--PLDREETPNHKLLVLASDGG--------LMPARAMVLVNVTDVNDNVPS-IDIRYIV 382

Query: 254 YVYEDTLPGSE-------VLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQ 306
               DT+  SE       +  +   D D     R+  +    ++  F +        + +
Sbjct: 383 NPVNDTVVLSENIPLNTKIALITVTDKDADHNGRV--TCFTDHEIPFRLRPVFSNQFLLE 440

Query: 307 SPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
           + A L  E  + +      + AG P    +  + I++ D N++ P F      Q+   +S
Sbjct: 441 NAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVF-----TQSFVTVS 495

Query: 367 MNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENS 426
           + E+   G  ++ +K++  D+D G NA+ N  L+GP       P+  L+     + V   
Sbjct: 496 IPENNSPG--IQLMKVSATDADSGPNAEINY-LLGPDA----PPEFSLDRRTGMLTVVKK 548

Query: 427 AAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAP 486
             +D EK     F +LA +   P   +S   V + ++D NDN P F    Y   +PEN P
Sbjct: 549 --LDREKEDKYLFTILAKDNGVPP-LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLP 605

Query: 487 GGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNF 546
              +V  +T  DPD G    V  S      D F I   TG+I  +P  S D E    Y F
Sbjct: 606 RHGTVGLITVTDPDYGDNSAVTLSILDENDD-FTIDSQTGVI--RPNISFDREKQESYTF 662

Query: 547 YVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP--------VKIEAI 596
           YVKAED     + S A+V I ++DVND+ P F       +  L  P         ++ A+
Sbjct: 663 YVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722

Query: 597 DEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLWSLE 655
           D D    N  V YSI      ++F I+  TG I L       D  LH +           
Sbjct: 723 DNDT-GMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL---------- 771

Query: 656 VQAKDRGSPSFSTTALLKIDITDAETLSRSPMAAFLIQ-------------------TKD 696
           V+A D G P  S  +++ +++   E+++ + +   L++                   T D
Sbjct: 772 VKANDLGQPD-SLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSD 830

Query: 697 NPMKAVGVLAGTMATVVAITVLISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWL 756
                V  +AGT+  VV I   I+     R     K         +  +P P   ++  +
Sbjct: 831 YVKILVAAVAGTITVVVVI--FITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMM 888

Query: 757 KSKSTK 762
           K K  K
Sbjct: 889 KKKKKK 894



 Score =  140 bits (352), Expect = 7e-33
 Identities = 171/630 (27%), Positives = 266/630 (42%), Gaps = 61/630 (9%)

Query: 71  ISFDPSTRSVFSVDPTFGNITLVEELDRERED--EIEAIISISDGLNLVAEKVVILVTDA 128
           I  +  T  +F+         L   + R+     E+E  I   +   LV  K+  L+ D 
Sbjct: 96  IRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDI 153

Query: 129 NDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL---QNLHSPFAVDR 185
           ND AP F        +PE+    S      AVD D G  G   Y L   QN+     ++ 
Sbjct: 154 NDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIET 213

Query: 186 HSG--VLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
             G  + +L     LD E   T+ + V  +DGG          S+T  + V+V D  D  
Sbjct: 214 PEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQR------SSTAILQVSVTDTNDNH 267

Query: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGA----FEINETS 299
           PVF  T     + E+   G+ V ++ A D D G+  +I +S  N         F +N T+
Sbjct: 268 PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATT 327

Query: 300 GAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES-- 357
           G I+I +    L RE    H  +   S  G   A+A V   + + D+N++ P+       
Sbjct: 328 GLITIKEP---LDREETPNHKLLVLASDGGLMPARAMV--LVNVTDVNDNVPSIDIRYIV 382

Query: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
            P N   +     P   +I     ITV D D   N +           FR+ P    N+ 
Sbjct: 383 NPVNDTVVLSENIPLNTKIAL---ITVTDKDADHNGRVTC-FTDHEIPFRLRP-VFSNQ- 436

Query: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
               ++EN+A +D+E +K    KLLA +   P   + +A + I++ D NDN P F   + 
Sbjct: 437 ---FLLENAAYLDYESTKEYAIKLLAADAGKPP-LNQSAMLFIKVKDENDNAPVFTQSFV 492

Query: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLD 537
              IPEN   G  ++ V+A D D+GP  E+ Y         F +   TG++       LD
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVK--KLD 550

Query: 538 AEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTP 590
            E   +Y F + A+D  +    S   VF++++D ND+ P F  +     V +     GT 
Sbjct: 551 REKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 610

Query: 591 VKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDC 650
             I   D D  + N+ V  SI   +  + F I+S TG I             NI+  R+ 
Sbjct: 611 GLITVTDPDYGD-NSAVTLSI--LDENDDFTIDSQTGVI-----------RPNISFDREK 656

Query: 651 --LWSLEVQAKDRGSPSFSTTALLKIDITD 678
              ++  V+A+D G  S S++A + I++ D
Sbjct: 657 QESYTFYVKAEDGGRVSRSSSAKVTINVVD 686


>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
          Length = 1203

 Score =  176 bits (445), Expect = 1e-43
 Identities = 197/745 (26%), Positives = 309/745 (41%), Gaps = 99/745 (13%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD 84
           V  TN N  +F       S+PE+T + S     + TDP+            + +SVF +D
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191

Query: 85  -------PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPR 134
                    +  + + + LDRE++D     I + DG         IL   V+D ND  P 
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 135 FIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP-----FAVDRHSGV 189
           F +      +PE+ P G+ + ++HA D D GS   + Y      +P     FA++  +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311

Query: 190 LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAP----V 245
           + +Q   +LD E +  H +TV+A DG            A  TVT+NV DV D  P     
Sbjct: 312 ITVQ--RSLDREETAIHKVTVLASDGSST--------PARATVTINVTDVNDNPPNIDLR 361

Query: 246 FVGTPYYGYVY--EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAIS 303
           ++ +P  G VY  E     +++  +   D D     +++  +    +  F +        
Sbjct: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI--EREVPFHLKAVYDNQY 419

Query: 304 ITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRF 363
           + ++ + L  E  +        S +G P+   T  V +++ D N++PP F      Q   
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF-----NQPVI 474

Query: 364 ELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIV 423
           ELS++E+  +G  L    I+  D D G NA    QL GP   F        +  + T ++
Sbjct: 475 ELSVSENNRRGLYL--TTISATDEDSGKNADIVYQL-GPNASF-------FDLDRKTGVL 524

Query: 424 ENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPE 483
             S   D E+ +   F + A +  TP    S A V++ +LD NDN PKF   ++   + E
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583

Query: 484 NAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATAR 543
           N P  S+V  +T  D D G    V  S      D F++ P +G+I +    S D E  + 
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN-DNFVLDPYSGVIKSN--VSFDREQQSS 640

Query: 544 YNFYVKAED--MEGKYSVAEVFITLLDVNDHPP--------QFGKSVQKKTMVLGTPVKI 593
           Y F VKA D     + S A+V I ++DVND+ P           K V    +      ++
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEV 700

Query: 594 EAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLW 652
            A+D D    N  + Y+I       +F I+  TG I L+      D  LH          
Sbjct: 701 FAVDVDT-GMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR--------- 750

Query: 653 SLEVQAKDRGSP-SFSTTALLKIDITDAE-------TLSRSPMAAFL----------IQT 694
            L V   D G P S  T  L+ + + D          L R  M   L           Q 
Sbjct: 751 -LVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQN 809

Query: 695 KDNPMKAVGVLAGTMATVVAITVLI 719
           +D     + ++AG M  +V I V +
Sbjct: 810 EDYLTIMIAIIAGAMVVIVVIFVTV 834



 Score =  163 bits (412), Expect = 7e-40
 Identities = 201/761 (26%), Positives = 310/761 (40%), Gaps = 91/761 (11%)

Query: 44  LPEDTPVG--------SHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNI-TLVE 94
           LPE+ P+G        SH+    GT      + Y +        +  V  + G I T   
Sbjct: 34  LPENVPIGNIPKDLNISHINAATGTSAS---LVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 95  ELDRER--------ED-----EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYV 141
            +DRE+        E+     E+E +I  +D   L+  K+ I+V D ND AP F      
Sbjct: 91  RIDREKLCAGASYAEENECFFELEVVILPNDFFRLI--KIKIIVKDTNDNAPMFPSPVIN 148

Query: 142 ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVD-----RHSGVLRLQAGA 196
             +PE+    S      A D DTG  G   Y L N  S F +D           +L    
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 197 TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
            LD E+  T+ + +  +DGG          S+T  + V V DV D  PVF       ++ 
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQK------SSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262

Query: 257 EDTLPGSEVLKVVAMDGDRGKPNRILY----SLVNGNDGAFEINETSGAISITQSPAQLQ 312
           E+   G+ V+++ A D D G    I Y     +       F +N T+G I++ +S   L 
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS---LD 319

Query: 313 REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGE--SGPQNRFELSMNEH 370
           RE   +H      S   S  A+AT  VTI + D+N++PP         P N       + 
Sbjct: 320 REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377

Query: 371 PPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAID 430
           P   +I     ITV+D D   N K          I R VP  +        ++E S+ +D
Sbjct: 378 PVNTKI---ALITVSDKDTDVNGKVIC------FIEREVPFHLKAVYDNQYLLETSSLLD 428

Query: 431 FEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSS 490
           +E +K  +FK++A +   P   + TA V ++L D NDN P F+       + EN   G  
Sbjct: 429 YEGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLY 487

Query: 491 VVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKA 550
           +  ++A D D+G   ++ Y   G  A  F +   TG++        D E   R+ F V A
Sbjct: 488 LTTISATDEDSGKNADIVYQ-LGPNASFFDLDRKTGVLTAS--RVFDREEQERFIFTVTA 544

Query: 551 ED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEP 603
            D       S A V +T+LD ND+ P+F  +     V +      T   I   D DA E 
Sbjct: 545 RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGE- 603

Query: 604 NNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
           N  V  SI +     V D  S      +K+++       +    +   ++ +V+A D G 
Sbjct: 604 NKAVTLSILNDNDNFVLDPYSGV----IKSNV-------SFDREQQSSYTFDVKATDGGQ 652

Query: 664 PSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGT-MATVVAITV----- 717
           P  S+TA + I++ D      SP+           +  +  + G+ +A V A+ V     
Sbjct: 653 PPRSSTAKVTINVMDVN--DNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMN 710

Query: 718 --LISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWL 756
             L  T     NK   ++ P+   +     PAP  + +  L
Sbjct: 711 AELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRL 751



 Score =  114 bits (284), Expect = 5e-25
 Identities = 86/320 (26%), Positives = 150/320 (46%), Gaps = 22/320 (6%)

Query: 13  LLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHIS 72
           L+R+ L   N  P  F+  V          S+ E+   G ++ T++ TD +    +  + 
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIE-------LSVSENNRRGLYLTTISATDEDSGKNADIVY 506

Query: 73  FDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK---VVILVTDAN 129
                 S F +D   G +T     DRE ++     ++  D      +    V++ V D N
Sbjct: 507 QLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566

Query: 130 DEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV 189
           D +P+F    +   V E++P  S +  +   D D G   +VT  + N +  F +D +SGV
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGV 626

Query: 190 LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT 249
           ++  +  + D E+  ++   V A DGG          S+T  VT+NV DV D +PV +  
Sbjct: 627 IK--SNVSFDREQQSSYTFDVKATDGG------QPPRSSTAKVTINVMDVNDNSPVVISP 678

Query: 250 P---YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISIT 305
           P    +  V    +PGS V +V A+D D G    + Y++V+GN+ G F I+  +G I++ 
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLE 738

Query: 306 QSPAQLQREVYELHVQVTEM 325
           + PA     ++ L V ++++
Sbjct: 739 EKPAPTDVGLHRLVVNISDL 758


>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
          Length = 1237

 Score =  176 bits (445), Expect = 1e-43
 Identities = 197/745 (26%), Positives = 309/745 (41%), Gaps = 99/745 (13%)

Query: 32  VGSTNGNMALF-------SLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVD 84
           V  TN N  +F       S+PE+T + S     + TDP+            + +SVF +D
Sbjct: 132 VKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191

Query: 85  -------PTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIL---VTDANDEAPR 134
                    +  + + + LDRE++D     I + DG         IL   V+D ND  P 
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251

Query: 135 FIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP-----FAVDRHSGV 189
           F +      +PE+ P G+ + ++HA D D GS   + Y      +P     FA++  +G+
Sbjct: 252 FKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGL 311

Query: 190 LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAP----V 245
           + +Q   +LD E +  H +TV+A DG            A  TVT+NV DV D  P     
Sbjct: 312 ITVQ--RSLDREETAIHKVTVLASDGSST--------PARATVTINVTDVNDNPPNIDLR 361

Query: 246 FVGTPYYGYVY--EDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAIS 303
           ++ +P  G VY  E     +++  +   D D     +++  +    +  F +        
Sbjct: 362 YIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFI--EREVPFHLKAVYDNQY 419

Query: 304 ITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRF 363
           + ++ + L  E  +        S +G P+   T  V +++ D N++PP F      Q   
Sbjct: 420 LLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF-----NQPVI 474

Query: 364 ELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIV 423
           ELS++E+  +G  L    I+  D D G NA    QL GP   F        +  + T ++
Sbjct: 475 ELSVSENNRRGLYL--TTISATDEDSGKNADIVYQL-GPNASF-------FDLDRKTGVL 524

Query: 424 ENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPE 483
             S   D E+ +   F + A +  TP    S A V++ +LD NDN PKF   ++   + E
Sbjct: 525 TASRVFDREEQERFIFTVTARDNGTP-PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583

Query: 484 NAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATAR 543
           N P  S+V  +T  D D G    V  S      D F++ P +G+I +    S D E  + 
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDN-DNFVLDPYSGVIKSN--VSFDREQQSS 640

Query: 544 YNFYVKAED--MEGKYSVAEVFITLLDVNDHPP--------QFGKSVQKKTMVLGTPVKI 593
           Y F VKA D     + S A+V I ++DVND+ P           K V    +      ++
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEV 700

Query: 594 EAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLD-ALHNITPGRDCLW 652
            A+D D    N  + Y+I       +F I+  TG I L+      D  LH          
Sbjct: 701 FAVDVDT-GMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHR--------- 750

Query: 653 SLEVQAKDRGSP-SFSTTALLKIDITDAE-------TLSRSPMAAFL----------IQT 694
            L V   D G P S  T  L+ + + D          L R  M   L           Q 
Sbjct: 751 -LVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNIGDSSQPYQN 809

Query: 695 KDNPMKAVGVLAGTMATVVAITVLI 719
           +D     + ++AG M  +V I V +
Sbjct: 810 EDYLTIMIAIIAGAMVVIVVIFVTV 834



 Score =  163 bits (412), Expect = 7e-40
 Identities = 201/761 (26%), Positives = 310/761 (40%), Gaps = 91/761 (11%)

Query: 44  LPEDTPVG--------SHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNI-TLVE 94
           LPE+ P+G        SH+    GT      + Y +        +  V  + G I T   
Sbjct: 34  LPENVPIGNIPKDLNISHINAATGTSAS---LVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90

Query: 95  ELDRER--------ED-----EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYV 141
            +DRE+        E+     E+E +I  +D   L+  K+ I+V D ND AP F      
Sbjct: 91  RIDREKLCAGASYAEENECFFELEVVILPNDFFRLI--KIKIIVKDTNDNAPMFPSPVIN 148

Query: 142 ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVD-----RHSGVLRLQAGA 196
             +PE+    S      A D DTG  G   Y L N  S F +D           +L    
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQ 208

Query: 197 TLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVY 256
            LD E+  T+ + +  +DGG          S+T  + V V DV D  PVF       ++ 
Sbjct: 209 NLDREQKDTYVMKIKVEDGGTPQK------SSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262

Query: 257 EDTLPGSEVLKVVAMDGDRGKPNRILY----SLVNGNDGAFEINETSGAISITQSPAQLQ 312
           E+   G+ V+++ A D D G    I Y     +       F +N T+G I++ +S   L 
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRS---LD 319

Query: 313 REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGE--SGPQNRFELSMNEH 370
           RE   +H      S   S  A+AT  VTI + D+N++PP         P N       + 
Sbjct: 320 REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377

Query: 371 PPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAID 430
           P   +I     ITV+D D   N K          I R VP  +        ++E S+ +D
Sbjct: 378 PVNTKI---ALITVSDKDTDVNGKVIC------FIEREVPFHLKAVYDNQYLLETSSLLD 428

Query: 431 FEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSS 490
           +E +K  +FK++A +   P   + TA V ++L D NDN P F+       + EN   G  
Sbjct: 429 YEGTKEFSFKIVASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLY 487

Query: 491 VVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKA 550
           +  ++A D D+G   ++ Y   G  A  F +   TG++        D E   R+ F V A
Sbjct: 488 LTTISATDEDSGKNADIVYQ-LGPNASFFDLDRKTGVLTAS--RVFDREEQERFIFTVTA 544

Query: 551 ED--MEGKYSVAEVFITLLDVNDHPPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEP 603
            D       S A V +T+LD ND+ P+F  +     V +      T   I   D DA E 
Sbjct: 545 RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGE- 603

Query: 604 NNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
           N  V  SI +     V D  S      +K+++       +    +   ++ +V+A D G 
Sbjct: 604 NKAVTLSILNDNDNFVLDPYSGV----IKSNV-------SFDREQQSSYTFDVKATDGGQ 652

Query: 664 PSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGT-MATVVAITV----- 717
           P  S+TA + I++ D      SP+           +  +  + G+ +A V A+ V     
Sbjct: 653 PPRSSTAKVTINVMDVN--DNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMN 710

Query: 718 --LISTATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWL 756
             L  T     NK   ++ P+   +     PAP  + +  L
Sbjct: 711 AELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRL 751



 Score =  114 bits (284), Expect = 5e-25
 Identities = 86/320 (26%), Positives = 150/320 (46%), Gaps = 22/320 (6%)

Query: 13  LLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHIS 72
           L+R+ L   N  P  F+  V          S+ E+   G ++ T++ TD +    +  + 
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIE-------LSVSENNRRGLYLTTISATDEDSGKNADIVY 506

Query: 73  FDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK---VVILVTDAN 129
                 S F +D   G +T     DRE ++     ++  D      +    V++ V D N
Sbjct: 507 QLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDEN 566

Query: 130 DEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV 189
           D +P+F    +   V E++P  S +  +   D D G   +VT  + N +  F +D +SGV
Sbjct: 567 DNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGV 626

Query: 190 LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT 249
           ++  +  + D E+  ++   V A DGG          S+T  VT+NV DV D +PV +  
Sbjct: 627 IK--SNVSFDREQQSSYTFDVKATDGG------QPPRSSTAKVTINVMDVNDNSPVVISP 678

Query: 250 P---YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISIT 305
           P    +  V    +PGS V +V A+D D G    + Y++V+GN+ G F I+  +G I++ 
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLE 738

Query: 306 QSPAQLQREVYELHVQVTEM 325
           + PA     ++ L V ++++
Sbjct: 739 EKPAPTDVGLHRLVVNISDL 758


>gi|11128041 protocadherin gamma subfamily A, 10 isoform 1 precursor
           [Homo sapiens]
          Length = 936

 Score =  172 bits (437), Expect = 9e-43
 Identities = 187/728 (25%), Positives = 307/728 (42%), Gaps = 77/728 (10%)

Query: 42  FSLPEDTPVGSHVYTLN---GTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDR 98
           +S+PE+   GS V  ++   G  P                 +FS++P  G++     +DR
Sbjct: 37  YSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDR 96

Query: 99  EREDEIEAIISISDGLNLVAEKVVIL-----VTDANDEAPRFIQEPYVALVPEDIPAGSI 153
           E      A   +S  + LV ++V +      VTD ND AP+F  E     + E++ AG  
Sbjct: 97  EELCAQSARCVVSFNI-LVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMR 155

Query: 154 IFKVHAVDRDTGSGGSVTYFLQ-NLHSPFAV-DRHSGVL--RLQAGATLDYERSRTHYIT 209
                A+D D G     +Y L  N H    V  R +GV    L    +LD E    H++ 
Sbjct: 156 FPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLV 215

Query: 210 VVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVV 269
           + A DGG      D + S T  V+V V D  D APVF    Y   V E+   G+++L V 
Sbjct: 216 LTASDGG------DPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVT 269

Query: 270 AMDGDRGKPNRILYSLVNGNDG---AFEINETSGAISITQSPAQLQREVYELHVQVTEMS 326
           A D D G    + YS     D     F++N+ +G I I+++    +   YE+ +Q  +  
Sbjct: 270 ATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAED-- 327

Query: 327 PAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
             G+  A A V +T+  V+ N+   T      P       + E  P G ++  L +   D
Sbjct: 328 -GGAYLATAKVLITVEDVNDNSPELTITSLFSP-------VTEDSPLGTVVALLNVHDLD 379

Query: 387 SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEV 446
           S+Q      ++    P  + + +      ++   +++    A+D E+       + A + 
Sbjct: 380 SEQNGQVTCSILAYLPFKLEKSI------DSYYRLVIHR--ALDREQVSSYNITVTATDG 431

Query: 447 NTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
            +P   S+ A  ++Q+ D NDN P F  + Y   IPEN   G+S+ +VTA+DPD+    +
Sbjct: 432 GSP-PLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQ 490

Query: 507 VKYS-----TYGTGADLFL-IHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVA 560
           + YS       G     ++ I+  TG++Y     S D E        V A D       +
Sbjct: 491 IIYSLAEDTIQGVPLSSYISINSDTGVLYA--LRSFDYEQFHELQMQVTASDSGDPPLSS 548

Query: 561 EVFITL--LDVNDHPPQF-----------GKSVQKKTMVLGTPV-KIEAIDEDAEEPNNL 606
            V ++L  LD ND+ P+            G  +  ++   G  V K+ A+D D+ + N  
Sbjct: 549 NVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ-NAW 607

Query: 607 VDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSF 666
           + Y +  A    +F +  HTGE+    ++   DAL           SL V  +D G P  
Sbjct: 608 LSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQ---------SLVVAVQDHGQPPL 658

Query: 667 STTALLKIDITDAETLSRSPMAAF----LIQTKDNPMKAVGVLAGTMATVVAITVLISTA 722
           S T  L + + D+     + + +F      +T D  +  V  +A      +A  +++   
Sbjct: 659 SATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAH 718

Query: 723 TFWRNKKS 730
              R  KS
Sbjct: 719 RLRRWHKS 726


>gi|14196448 protocadherin gamma subfamily A, 10 isoform 2 precursor
           [Homo sapiens]
          Length = 850

 Score =  172 bits (437), Expect = 9e-43
 Identities = 187/728 (25%), Positives = 307/728 (42%), Gaps = 77/728 (10%)

Query: 42  FSLPEDTPVGSHVYTLN---GTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDR 98
           +S+PE+   GS V  ++   G  P                 +FS++P  G++     +DR
Sbjct: 37  YSIPEELEKGSFVGNISKDLGLAPRELAERGVRIVSRGRTQLFSLNPRSGSLITAGRIDR 96

Query: 99  EREDEIEAIISISDGLNLVAEKVVIL-----VTDANDEAPRFIQEPYVALVPEDIPAGSI 153
           E      A   +S  + LV ++V +      VTD ND AP+F  E     + E++ AG  
Sbjct: 97  EELCAQSARCVVSFNI-LVEDRVKLFGIEIEVTDINDNAPKFQAENLDVKINENVAAGMR 155

Query: 154 IFKVHAVDRDTGSGGSVTYFLQ-NLHSPFAV-DRHSGVL--RLQAGATLDYERSRTHYIT 209
                A+D D G     +Y L  N H    V  R +GV    L    +LD E    H++ 
Sbjct: 156 FPLPEAIDPDVGVNSLQSYQLSPNKHFSLRVQSRANGVKYPELVLEHSLDREEEAIHHLV 215

Query: 210 VVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVV 269
           + A DGG      D + S T  V+V V D  D APVF    Y   V E+   G+++L V 
Sbjct: 216 LTASDGG------DPLRSGTVLVSVTVFDANDNAPVFTLPEYRVSVPENLPVGTQLLTVT 269

Query: 270 AMDGDRGKPNRILYSLVNGNDG---AFEINETSGAISITQSPAQLQREVYELHVQVTEMS 326
           A D D G    + YS     D     F++N+ +G I I+++    +   YE+ +Q  +  
Sbjct: 270 ATDRDEGANGEVTYSFRKLPDTQLLKFQLNKYTGEIKISENLDYEETGFYEIEIQAED-- 327

Query: 327 PAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVND 386
             G+  A A V +T+  V+ N+   T      P       + E  P G ++  L +   D
Sbjct: 328 -GGAYLATAKVLITVEDVNDNSPELTITSLFSP-------VTEDSPLGTVVALLNVHDLD 379

Query: 387 SDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEV 446
           S+Q      ++    P  + + +      ++   +++    A+D E+       + A + 
Sbjct: 380 SEQNGQVTCSILAYLPFKLEKSI------DSYYRLVIHR--ALDREQVSSYNITVTATDG 431

Query: 447 NTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGE 506
            +P   S+ A  ++Q+ D NDN P F  + Y   IPEN   G+S+ +VTA+DPD+    +
Sbjct: 432 GSP-PLSTEAHFMLQVADINDNPPTFSQVSYFTYIPENNARGASIFSVTALDPDSKENAQ 490

Query: 507 VKYS-----TYGTGADLFL-IHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVA 560
           + YS       G     ++ I+  TG++Y     S D E        V A D       +
Sbjct: 491 IIYSLAEDTIQGVPLSSYISINSDTGVLYA--LRSFDYEQFHELQMQVTASDSGDPPLSS 548

Query: 561 EVFITL--LDVNDHPPQF-----------GKSVQKKTMVLGTPV-KIEAIDEDAEEPNNL 606
            V ++L  LD ND+ P+            G  +  ++   G  V K+ A+D D+ + N  
Sbjct: 549 NVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ-NAW 607

Query: 607 VDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSF 666
           + Y +  A    +F +  HTGE+    ++   DAL           SL V  +D G P  
Sbjct: 608 LSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQ---------SLVVAVQDHGQPPL 658

Query: 667 STTALLKIDITDAETLSRSPMAAF----LIQTKDNPMKAVGVLAGTMATVVAITVLISTA 722
           S T  L + + D+     + + +F      +T D  +  V  +A      +A  +++   
Sbjct: 659 SATVTLTVAVADSIPQVLADLGSFESPANSETSDLTLYLVVAVAAVSCVFLAFVIVLLAH 718

Query: 723 TFWRNKKS 730
              R  KS
Sbjct: 719 RLRRWHKS 726


>gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precursor
           [Homo sapiens]
          Length = 932

 Score =  165 bits (417), Expect = 2e-40
 Identities = 182/675 (26%), Positives = 285/675 (42%), Gaps = 79/675 (11%)

Query: 42  FSLPEDTPVGSHVYTLN---GTDPEGDPISYHISFDPSTR-SVFSVDPTFGNITLVEELD 97
           +S+PE+   GS V  +    G +P+ +   + +      R  +FS++P  G++     +D
Sbjct: 33  YSIPEELEKGSFVGNIVKDLGLEPQ-ELAEHGVRIVSRGRMQLFSLNPRNGSLVTAGRID 91

Query: 98  RER------EDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG 151
           RE          +   I + D LNL   +V I+  D ND  PRF++E     + E+    
Sbjct: 92  REELCAQSPRCLVSFNILVEDKLNLYPVEVEIV--DINDNTPRFLKEELEVKILENAAPS 149

Query: 152 SIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV-----LRLQAGATLDYERSRTH 206
           S    +   D D G   S+  F  + +S F+VD  S         L    TLD E    +
Sbjct: 150 SRFPLMEVYDPDVGM-NSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVY 208

Query: 207 YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL 266
            + + A DGG      D V S+   + V V DV D  P+F    Y   V E+   G+ VL
Sbjct: 209 RLVLTAMDGG------DPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVL 262

Query: 267 KVVAMDGDRGKPNRILYSLVNGND---GAFEINETSGAISITQSPAQLQREVYELHVQVT 323
            V A D D G    + YS V   +     F +N  +G IS + +        YEL V+  
Sbjct: 263 AVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEAR 322

Query: 324 EMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKIT 383
           +      P  +    V I I+D+N++ P     SG +     ++ E  P G ++      
Sbjct: 323 D-----GPGLRDRAKVLITILDVNDNVPEVVVTSGSR-----TIAESAPPGTVI--ALFQ 370

Query: 384 VNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
           V D D G N      +  PR +   + ++V N  ++      +AA+D E+  +    + A
Sbjct: 371 VFDRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLV----TNAALDREEVFLYNITVTA 424

Query: 444 VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGP 503
            +  TP   S+   + + + DTNDN P F    Y   + EN P G+S+ +V A+DPD   
Sbjct: 425 TDKGTP-PLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQ 483

Query: 504 WGEVKYSTYG---TGADL---FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY 557
             +V YS       GA L     I+  TG++Y     S D E       +V A D     
Sbjct: 484 NAQVSYSLAEDTLQGAPLSSYVSINSDTGILYA--LRSFDYEQLRDLQLWVTASDSGDPP 541

Query: 558 SVAEVFITL--LDVNDHPPQF-----------GKSVQKKTMVLGTPV-KIEAIDEDAEEP 603
             + V ++L  LD ND+ P+            G  +  ++   G  V K+ A+D D+ + 
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ- 600

Query: 604 NNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
           N  + Y +  A    +F +  HTGE+    ++   DAL           SL V  +D G 
Sbjct: 601 NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ---------SLVVAVQDHGQ 651

Query: 664 PSFSTTALLKIDITD 678
           P  S T  L + + D
Sbjct: 652 PPLSATVTLTVAVAD 666



 Score =  120 bits (302), Expect = 4e-27
 Identities = 110/385 (28%), Positives = 174/385 (45%), Gaps = 54/385 (14%)

Query: 338 PVTIRIVDLNNHPPTFYGE---------SGPQNRFELSMNEHPPQG-EILRGLKITVNDS 387
           PV + IVD+N++ P F  E         + P +RF L     P  G   L+G K++ N  
Sbjct: 118 PVEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSH 177

Query: 388 DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
               +     +  GP+      P+ VL              +D E   V    L A++  
Sbjct: 178 ---FSVDVQSEAHGPK-----YPELVLE-----------GTLDREGEAVYRLVLTAMDGG 218

Query: 448 TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEV 507
            P + SS A +++ +LD NDN P F    Y   +PEN P G+ V+AVTA D D G  GEV
Sbjct: 219 DPVR-SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEV 277

Query: 508 KYSTYGTG---ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFI 564
            YS        + +F ++  TG I T   A+LD E ++ Y   V+A D  G    A+V I
Sbjct: 278 TYSFVKITEKISQIFCLNVLTGEISTS--ANLDYEDSSFYELGVEARDGPGLRDRAKVLI 335

Query: 565 TLLDVNDHPPQF----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVF 620
           T+LDVND+ P+     G     ++   GT + +  + +     N LV  SI  + P   F
Sbjct: 336 TILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLP---F 392

Query: 621 DINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAE 680
           ++    G  +   +  +LD           L+++ V A D+G+P  ST  ++ +++ D  
Sbjct: 393 ELEKSVGNYYRLVTNAALDREEVF------LYNITVTATDKGTPPLSTETIISLNVADTN 446

Query: 681 ----TLSRSPMAAFLIQTKDNPMKA 701
               T   S  + ++++  +NP  A
Sbjct: 447 DNPPTFPHSSYSVYVLE--NNPRGA 469


>gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precursor
           [Homo sapiens]
          Length = 818

 Score =  165 bits (417), Expect = 2e-40
 Identities = 182/675 (26%), Positives = 285/675 (42%), Gaps = 79/675 (11%)

Query: 42  FSLPEDTPVGSHVYTLN---GTDPEGDPISYHISFDPSTR-SVFSVDPTFGNITLVEELD 97
           +S+PE+   GS V  +    G +P+ +   + +      R  +FS++P  G++     +D
Sbjct: 33  YSIPEELEKGSFVGNIVKDLGLEPQ-ELAEHGVRIVSRGRMQLFSLNPRNGSLVTAGRID 91

Query: 98  RER------EDEIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG 151
           RE          +   I + D LNL   +V I+  D ND  PRF++E     + E+    
Sbjct: 92  REELCAQSPRCLVSFNILVEDKLNLYPVEVEIV--DINDNTPRFLKEELEVKILENAAPS 149

Query: 152 SIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV-----LRLQAGATLDYERSRTH 206
           S    +   D D G   S+  F  + +S F+VD  S         L    TLD E    +
Sbjct: 150 SRFPLMEVYDPDVGM-NSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVY 208

Query: 207 YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL 266
            + + A DGG      D V S+   + V V DV D  P+F    Y   V E+   G+ VL
Sbjct: 209 RLVLTAMDGG------DPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVL 262

Query: 267 KVVAMDGDRGKPNRILYSLVNGND---GAFEINETSGAISITQSPAQLQREVYELHVQVT 323
            V A D D G    + YS V   +     F +N  +G IS + +        YEL V+  
Sbjct: 263 AVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEAR 322

Query: 324 EMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKIT 383
           +      P  +    V I I+D+N++ P     SG +     ++ E  P G ++      
Sbjct: 323 D-----GPGLRDRAKVLITILDVNDNVPEVVVTSGSR-----TIAESAPPGTVI--ALFQ 370

Query: 384 VNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
           V D D G N      +  PR +   + ++V N  ++      +AA+D E+  +    + A
Sbjct: 371 VFDRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLV----TNAALDREEVFLYNITVTA 424

Query: 444 VEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGP 503
            +  TP   S+   + + + DTNDN P F    Y   + EN P G+S+ +V A+DPD   
Sbjct: 425 TDKGTP-PLSTETIISLNVADTNDNPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQ 483

Query: 504 WGEVKYSTYG---TGADL---FLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKY 557
             +V YS       GA L     I+  TG++Y     S D E       +V A D     
Sbjct: 484 NAQVSYSLAEDTLQGAPLSSYVSINSDTGILYA--LRSFDYEQLRDLQLWVTASDSGDPP 541

Query: 558 SVAEVFITL--LDVNDHPPQF-----------GKSVQKKTMVLGTPV-KIEAIDEDAEEP 603
             + V ++L  LD ND+ P+            G  +  ++   G  V K+ A+D D+ + 
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ- 600

Query: 604 NNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGS 663
           N  + Y +  A    +F +  HTGE+    ++   DAL           SL V  +D G 
Sbjct: 601 NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQ---------SLVVAVQDHGQ 651

Query: 664 PSFSTTALLKIDITD 678
           P  S T  L + + D
Sbjct: 652 PPLSATVTLTVAVAD 666



 Score =  120 bits (302), Expect = 4e-27
 Identities = 110/385 (28%), Positives = 174/385 (45%), Gaps = 54/385 (14%)

Query: 338 PVTIRIVDLNNHPPTFYGE---------SGPQNRFELSMNEHPPQG-EILRGLKITVNDS 387
           PV + IVD+N++ P F  E         + P +RF L     P  G   L+G K++ N  
Sbjct: 118 PVEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSH 177

Query: 388 DQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVN 447
               +     +  GP+      P+ VL              +D E   V    L A++  
Sbjct: 178 ---FSVDVQSEAHGPK-----YPELVLE-----------GTLDREGEAVYRLVLTAMDGG 218

Query: 448 TPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEV 507
            P + SS A +++ +LD NDN P F    Y   +PEN P G+ V+AVTA D D G  GEV
Sbjct: 219 DPVR-SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEV 277

Query: 508 KYSTYGTG---ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFI 564
            YS        + +F ++  TG I T   A+LD E ++ Y   V+A D  G    A+V I
Sbjct: 278 TYSFVKITEKISQIFCLNVLTGEISTS--ANLDYEDSSFYELGVEARDGPGLRDRAKVLI 335

Query: 565 TLLDVNDHPPQF----GKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVF 620
           T+LDVND+ P+     G     ++   GT + +  + +     N LV  SI  + P   F
Sbjct: 336 TILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLP---F 392

Query: 621 DINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAE 680
           ++    G  +   +  +LD           L+++ V A D+G+P  ST  ++ +++ D  
Sbjct: 393 ELEKSVGNYYRLVTNAALDREEVF------LYNITVTATDKGTPPLSTETIISLNVADTN 446

Query: 681 ----TLSRSPMAAFLIQTKDNPMKA 701
               T   S  + ++++  +NP  A
Sbjct: 447 DNPPTFPHSSYSVYVLE--NNPRGA 469


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,160,743
Number of Sequences: 37866
Number of extensions: 1826774
Number of successful extensions: 17689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 286
Number of HSP's that attempted gapping in prelim test: 9413
Number of HSP's gapped (non-prelim): 2984
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.