BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|11225266 transient receptor potential cation channel, subfamily M, member 5 [Homo sapiens] (1165 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|11225266 transient receptor potential cation channel, subfami... 2351 0.0 gi|21314671 transient receptor potential cation channel, subfami... 919 0.0 gi|4507689 transient receptor potential cation channel, subfamil... 758 0.0 gi|109689695 transient receptor potential cation channel, subfam... 571 e-162 gi|154091314 transient receptor potential cation channel, subfam... 470 e-132 gi|154091316 transient receptor potential cation channel, subfam... 466 e-131 gi|154091318 transient receptor potential cation channel, subfam... 466 e-131 gi|154091312 transient receptor potential cation channel, subfam... 465 e-130 gi|154091320 transient receptor potential cation channel, subfam... 465 e-130 gi|154091310 transient receptor potential cation channel, subfam... 460 e-129 gi|154091308 transient receptor potential cation channel, subfam... 459 e-129 gi|18921093 transient receptor potential cation channel, subfami... 427 e-119 gi|148612863 transient receptor potential cation channel, subfam... 418 e-116 gi|94538366 transient receptor potential cation channel, subfami... 316 9e-86 gi|45935368 transient receptor potential cation channel, subfami... 125 2e-28 gi|55953096 transient receptor potential cation channel, subfami... 120 1e-26 gi|6912736 transient receptor potential cation channel, subfamil... 69 3e-11 gi|209863032 transient receptor potential cation channel, subfam... 65 4e-10 gi|209863030 transient receptor potential cation channel, subfam... 65 4e-10 gi|209863026 transient receptor potential cation channel, subfam... 65 4e-10 gi|209863024 transient receptor potential cation channel, subfam... 65 4e-10 gi|7706747 transient receptor potential cation channel, subfamil... 65 4e-10 gi|22547184 transient receptor potential cation channel, subfami... 58 5e-08 gi|21735483 transient receptor potential cation channel, subfami... 52 4e-06 gi|22547180 transient receptor potential cation channel, subfami... 51 6e-06 gi|5730102 transient receptor potential cation channel, subfamil... 49 4e-05 gi|209863028 transient receptor potential cation channel, subfam... 47 1e-04 gi|9966865 transient receptor potential cation channel, subfamil... 46 2e-04 gi|194733735 transient receptor potential cation channel, subfam... 45 3e-04 gi|4507687 transient receptor potential cation channel, subfamil... 45 3e-04 >gi|11225266 transient receptor potential cation channel, subfamily M, member 5 [Homo sapiens] Length = 1165 Score = 2351 bits (6093), Expect = 0.0 Identities = 1165/1165 (100%), Positives = 1165/1165 (100%) Query: 1 MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW 60 MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW Sbjct: 1 MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW 60 Query: 61 HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV 120 HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV Sbjct: 61 HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV 120 Query: 121 RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL 180 RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL Sbjct: 121 RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL 180 Query: 181 SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI 240 SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI Sbjct: 181 SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI 240 Query: 241 SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT 300 SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT Sbjct: 241 SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT 300 Query: 301 KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR 360 KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR Sbjct: 301 KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR 360 Query: 361 VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR 420 VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR Sbjct: 361 VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR 420 Query: 421 SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG 480 SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG Sbjct: 421 SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG 480 Query: 481 FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM 540 FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM Sbjct: 481 FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM 540 Query: 541 GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV 600 GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV Sbjct: 541 GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV 600 Query: 601 RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV 660 RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV Sbjct: 601 RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV 660 Query: 661 YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL 720 YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL Sbjct: 661 YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL 720 Query: 721 LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL 780 LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL Sbjct: 721 LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL 780 Query: 781 EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM 840 EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM Sbjct: 781 EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM 840 Query: 841 DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900 DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG Sbjct: 841 DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900 Query: 901 RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV 960 RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV Sbjct: 901 RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV 960 Query: 961 TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020 TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL Sbjct: 961 TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020 Query: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK Sbjct: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080 Query: 1081 TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ 1140 TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ Sbjct: 1081 TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ 1140 Query: 1141 LVAADHRGGLDGWEQPGAGQPPSDT 1165 LVAADHRGGLDGWEQPGAGQPPSDT Sbjct: 1141 LVAADHRGGLDGWEQPGAGQPPSDT 1165 >gi|21314671 transient receptor potential cation channel, subfamily M, member 4 [Homo sapiens] Length = 1214 Score = 919 bits (2375), Expect = 0.0 Identities = 523/1148 (45%), Positives = 700/1148 (60%), Gaps = 63/1148 (5%) Query: 26 GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85 GE++F G+G+K F+R+ P+ ++ L+ W APNLVVS++G +++WL+ Sbjct: 76 GELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQ 135 Query: 86 DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145 D+LR+GLV+AAQSTGAWI+T L G+ RHVG AVRDH +AST +VVA+G+A G V Sbjct: 136 DLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG-TKVVAMGVAPWGVV 194 Query: 146 LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205 +R L + FP Y G LD N S F LV+ G G G RLRLE Sbjct: 195 RNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLE 254 Query: 206 KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265 +IS+Q+ G GGTG I+IPVL LL++GD L RI A + P L++ GSGG AD LA Sbjct: 255 SYISQQKTGVGGTG-IDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAE 313 Query: 266 LVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEE 325 + A + + F D+ ++ I + + LLTVY E +GSEE Sbjct: 314 TLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSE-DGSEE 372 Query: 326 LDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMV 385 +T++LKALVKAC S E YLDEL+LAVAW+RVDIA+SE+F GD++W+S LE ++ Sbjct: 373 FETIVLKALVKACGS--SEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430 Query: 386 DALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAG 445 DAL++++PEFVRL + +G + FLT RL +LY + SL+ +LL + A Sbjct: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPA 490 Query: 446 L--GTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEK-GPAKRPT 502 L G + R P +V VL+ L C Y G D + G + Sbjct: 491 LKGGAAELRPP----------DVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL 540 Query: 503 GQKWLLDLNQKS---ENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMS 559 K L+ + + PW DL LWA+L NR +MA YFW MG V++AL AC +L+ M+ Sbjct: 541 SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA 600 Query: 560 HLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATE 617 LE +AE A ++ K+E + +DLF ECY +SE RA LL+RR W TCL LA + Sbjct: 601 RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ 660 Query: 618 ADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITF--SEEAPLRT 675 ADA+AFFA DGVQ+ LT+ WWGDMA+ TPI L+ AF CP L+YT LITF SEE P R Sbjct: 661 ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE 720 Query: 676 GLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----RAVFLLTRWRKFWGA 730 LE D+DS+ + P+ + + PR G G L RW FWGA Sbjct: 721 ELEF--DMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGA 778 Query: 731 PVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTD 790 PVT+F+GNVV Y FL LF+ VLLVDF+P P P E+ LYFW FTL+ EE+RQG Sbjct: 779 PVTIFMGNVVSYLLFLLLFSRVLLVDFQPAP--PGSLELLLYFWAFTLLCEELRQGLSGG 836 Query: 791 EDT-----------HLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLA 839 + L ++ LY+ D+WN+CD+VA+ F++GV CR+ P + GRTVL Sbjct: 837 GGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLC 896 Query: 840 MDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHD 899 +DFMVFT+RL+HIF ++KQLGPKI++V +MMKDVFFFLFFL VWLVAYGV T+ LL P D Sbjct: 897 IDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRD 956 Query: 900 GRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV---NCSTHPLLLEDSP-----SCPSLYA 951 I RRV YRPYLQIFGQIP +++D A + NCS+ P P +C S YA Sbjct: 957 SDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYA 1016 Query: 952 NWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALA 1011 NWLV+LLLV FLLV N+LL+NLLIAMFSYTF VQGN+D++WK QRY LI E+H RPALA Sbjct: 1017 NWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALA 1076 Query: 1012 PPFILLSHLSLTLRRVFKK-----EAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKM 1066 PPFI++SHL L LR++ ++ + EH L ++K++TWE+V KENFL Sbjct: 1077 PPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLAR 1136 Query: 1067 EKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQG 1126 + +R+S+ E L++T+ +VD K LG +RE E+R+K LE ++ CS ++ VA+ L++ Sbjct: 1137 ARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRS 1196 Query: 1127 -----GGP 1129 GGP Sbjct: 1197 ALLPPGGP 1204 >gi|4507689 transient receptor potential cation channel, subfamily M, member 2 [Homo sapiens] Length = 1503 Score = 758 bits (1958), Expect = 0.0 Identities = 458/1172 (39%), Positives = 653/1172 (55%), Gaps = 104/1172 (8%) Query: 26 GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85 G++ F G +K K+VRV SV++ L+ W L PNL++S+ G + F MK L+ Sbjct: 128 GDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLK 187 Query: 86 DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145 + R+GLVK AQ+TGAWI+T G+ + VG+AVRD SL+S+ + ++ +G+A+ G V Sbjct: 188 SIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTV 247 Query: 146 LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205 R L FP Y D+ G QG L LDSN SHFILV+ G G+ LR RLE Sbjct: 248 HRREGLIHPTGSFPAEYILDEDG-QGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLE 306 Query: 206 KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265 K ISEQ GG +I+IP++C+++ G P TL I A P +++ GSG +ADV+A Sbjct: 307 KFISEQTKERGGV-AIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQ 365 Query: 266 LVNQP--HLLVPKVAEKQ---FKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQ 320 + N P + + + +K F+E F + F+ IV WTK +Q+I + LLTV+ + Sbjct: 366 VANLPVSDITISLIQQKLSVFFQEMFET--FTESRIVEWTKKIQDIVRRRQLLTVFREGK 423 Query: 321 EGSEELDTVILKALVKACKSHSQEPQDYLD-ELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379 +G +++D IL+AL+KA +S + D +LKLAVAW+RVDIA+SEIF + +WK D Sbjct: 424 DGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSD 483 Query: 380 LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEA 439 L M AL+SNKPEFV+LF++NG + +F+T+ L LY ++ L LQ+ Sbjct: 484 LHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQK----- 538 Query: 440 RLTLAGLGTQQAREPPAGP--PAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRR--AEK 495 + + P P P +H V++VL++ L D + Y R DR R Sbjct: 539 ------VLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592 Query: 496 GPAKRPTGQKWLLDLNQKSE-------NPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAA 548 K L L ++S +P RDL +WA++QNR E+A WA Q+ +AAA Sbjct: 593 PHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652 Query: 549 LAACKILKEMSHLE--TEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCW 606 LA KILKE+S E T++ +YE A+ +F+ECY E RA LL R + W Sbjct: 653 LACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712 Query: 607 SKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLIT 666 KTTCL LA EA F +H G+QAFLT++WWG ++ + R+ L L+ T LI+ Sbjct: 713 GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLIS 772 Query: 667 FSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRK 726 F E+ LQD V P A R R Sbjct: 773 FREKR--------LQD---------------------VGTPAA-------------RARA 790 Query: 727 FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786 F+ APV VF N++ YFAFL LF YVL+VDF+P PS E +Y W+F+LV EE+RQ Sbjct: 791 FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPV---PSWCECAIYLWLFSLVCEEMRQL 847 Query: 787 FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFT 846 F+ ++ L+KK LY D WNK D+ AI LF+ G+TCR++P+ GR +L++DF++F Sbjct: 848 FYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFC 907 Query: 847 LRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIF 906 LRL+HIF I K LGPKII+V+RMMKDVFFFLF L+VW+V++GV QA+L ++ R++W+F Sbjct: 908 LRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLF 967 Query: 907 RRVLYRPYLQIFGQIP--LDEIDEARVNCS---THPLLLEDSPSCPS--------LYANW 953 R +Y YL IFGQIP +D ++ +CS T P P CP + W Sbjct: 968 RGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPY----KPKCPESDATQQRPAFPEW 1023 Query: 954 LVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPP 1013 L +LLL +LL TN+LL+NLLIAMF+YTFQ VQ + D WKFQR++LI EYH RPA PP Sbjct: 1024 LTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPP 1083 Query: 1014 FILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDS 1073 FILLSHL L ++RV K + + L+ L + +++WE KEN+L + +++ Sbjct: 1084 FILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQR 1143 Query: 1074 EGEVLRKTAHRVDFIAKYLG-----GLREQEKRIKCLESQINYCSVLVSSVADVLAQGGG 1128 + + +++VD + L E+R+ LE Q+ + + + L G Sbjct: 1144 PEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGF 1203 Query: 1129 PRSSQHCGEGSQLVAAD---HRGGLDGWEQPG 1157 + SQ A + GG E+PG Sbjct: 1204 SSEADVPTLASQKAAEEPDAEPGGRKKTEEPG 1235 >gi|109689695 transient receptor potential cation channel, subfamily M, member 8 [Homo sapiens] Length = 1104 Score = 571 bits (1472), Expect = e-162 Identities = 374/1103 (33%), Positives = 577/1103 (52%), Gaps = 127/1103 (11%) Query: 26 GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85 G++ F GKK GK++R+ +L++LL WHL PNLV+S+ G + FA+K +R Sbjct: 104 GDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMR 162 Query: 86 DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145 + + L+ AQS GAWILT GL +++G+ VRD+++ S S++ +VA+G+A+ G V Sbjct: 163 KIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTI-SRSSEENIVAIGIAAWGMV 220 Query: 146 LHRRILE---EAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRL 202 +R L +A+ F Y DD ++ PL LD+N +H +LV+ G G +LR Sbjct: 221 SNRDTLIRNCDAEGYFLAQYLMDDF-TRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRN 279 Query: 203 RLEKHISE---QRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGI 259 +LEK+ISE Q + YGG +IP++C G TL+ I+ +++ P +++ GSG I Sbjct: 280 QLEKYISERTIQDSNYGG----KIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQI 335 Query: 260 ADVLAALVNQPHLLVPKVAEKQFKEKFPS--KHFSWEDIVRWTKLLQNITSHQHLLTVYD 317 ADV+A+LV L +++ P E+ W K L+ I HLLTV Sbjct: 336 ADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIK 395 Query: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377 E+ G E + I AL KA + Q+ ++ +LKL + W+++D+A EIF D W+S Sbjct: 396 MEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWES 455 Query: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQ---R 434 DL+EVM AL+ ++P+FVRLF++NG ++ FLT+ L EL+ S +L++ LQ Sbjct: 456 ADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELF-SNHFSTLVYRNLQIAKN 514 Query: 435 KQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAE 494 +A LT V +++ +F RGF ++ R G Sbjct: 515 SYNDALLTF----------------------VWKLVANFR----RGFRKEDRNG------ 542 Query: 495 KGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKI 554 R L D++ + +P + LF+WA+LQN+ E++ W + AAL A K+ Sbjct: 543 -----RDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKL 597 Query: 555 LKEMSHLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCL 612 LK ++ ++ + AA + E +YE A++LF+ECYS+ E A LLV W + CL Sbjct: 598 LKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCL 657 Query: 613 HLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAP 672 LA EA + F A GVQ FL++ W+G+++ T +++ LV ++F ++ Sbjct: 658 ELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKK-- 715 Query: 673 LRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPV 732 +D K LL + F+ +P Sbjct: 716 ------------PVDKHKK----------------------------LLWYYVAFFTSPF 735 Query: 733 TVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDED 792 VF NVV Y AFL LF YVLL+DF P PE+ LY VF L +E+RQ + + Sbjct: 736 VVFSWNVVFYIAFLLLFAYVLLMDFHSVPH---PPELVLYSLVFVLFCDEVRQWYVNGVN 792 Query: 793 THLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRM---LPSAFEAGRTVLAMDFMVFTLRL 849 Y D WN D + +F FI G+ R+ S+ +GR + +D+++FTLRL Sbjct: 793 ---------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRL 843 Query: 850 IHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRV 909 IHIF + + LGPKII+++RM+ DVFFFLF +VW+VA+GV Q +L ++ R WIFR V Sbjct: 844 IHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSV 903 Query: 910 LYRPYLQIFGQIPLDEIDEAR---VNCS-----THPLLLE-DSPSCPSLYANWLVILLLV 960 +Y PYL +FGQ+P D +D +C+ + PL +E D + P + W+ I L+ Sbjct: 904 IYEPYLAMFGQVPSD-VDGTTYDFAHCTFTGNESKPLCVELDEHNLPR-FPEWITIPLVC 961 Query: 961 TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL 1020 ++L TN+LL+NLL+AMF YT VQ N D WKFQRY L+ EY R + PFI+ ++ Sbjct: 962 IYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYF 1021 Query: 1021 SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080 + +++ FK + K D + + WE V KEN+L K+ + D+ E+ + Sbjct: 1022 YMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHR 1081 Query: 1081 TAHRVDFIAKYLGGLREQEKRIK 1103 + G L+E +IK Sbjct: 1082 FRQLDTKLNDLKGLLKEIANKIK 1104 >gi|154091314 transient receptor potential cation channel, subfamily M, member 3 isoform k [Homo sapiens] Length = 1707 Score = 470 bits (1209), Expect = e-132 Identities = 348/1159 (30%), Positives = 567/1159 (48%), Gaps = 136/1159 (11%) Query: 26 GEVNFGGSG-KKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84 G + F G G + +VRV P +L L+ EW L P L++S+ G Q F ++ L Sbjct: 140 GTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKL 199 Query: 85 RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144 + V KGL+KAA +TGAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G Sbjct: 200 KQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGI 256 Query: 145 VLHRRILEEAQEDF----PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTEL 200 V E QED V + L L+S SHFIL + G GK +L Sbjct: 257 V-------ENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKL 309 Query: 201 RLRLEKHISEQ----RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV-- 254 R +LEKHIS Q R G G +PV+ L+V G PN + + + P ++V Sbjct: 310 RRQLEKHISLQKINTRIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCD 363 Query: 255 GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKL 302 GSG +D+LA L+N+ LLV +K F ++ + Sbjct: 364 GSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFII 414 Query: 303 LQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVD 362 L + L+TV+ EG +++D IL AL+K + + D+L LA+AW+RVD Sbjct: 415 LMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVD 468 Query: 363 IAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSV 422 IA+S+IF +W LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + Sbjct: 469 IARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTR 528 Query: 423 SRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRG 480 S L R ++ L PP + SL ++ V++ + A R Sbjct: 529 HGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGGAYRC 572 Query: 481 FYQDGRPGDRRRAEKGPAKRPTGQKWL-----------------------LDLNQKSEN- 516 Y R GP KRP K L +DL+ N Sbjct: 573 NYTRKRFRTLYHNLFGP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINH 631 Query: 517 ---PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATRE 573 P+ +L +WAVL R +MA +FW G+E +A AL ACK+ K M+H +E + + Sbjct: 632 FPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQ 691 Query: 574 A------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHD 627 + +LA++L + Y E A LL + WS TCL LA A + F AH Sbjct: 692 ELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHT 751 Query: 628 GVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDL 683 Q LT +W G M + + +LG L P+++ ++ P + ++ LQ+ Sbjct: 752 CSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEK 810 Query: 684 DSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPV 732 ++ + EK + +E R G+ R + L + +F+ AP+ Sbjct: 811 EAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPI 870 Query: 733 TVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDED 792 F + Y +L LF Y++LV + PS E + ++FTL +E++R+ E Sbjct: 871 VKFWFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEP 926 Query: 793 THLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIH 851 L++K +++ + WN D++AI LF VG+ R+ F + GR + ++ + + +RL+ Sbjct: 927 GKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLD 986 Query: 852 IFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLY 911 IF ++K LGP ++++ +MM D+ +F+ + V L+++GV QA+L P++ + + + Y Sbjct: 987 IFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFY 1046 Query: 912 RPYLQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLL 970 PY I+G++ D+ID N + + P C + W+V ++ +LLV N+LL Sbjct: 1047 MPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILL 1104 Query: 971 MNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKK 1030 +NLLIA+F+ TF V+ ++ WKFQRY LI+ +HERP L PP I+ SH+++ + + + Sbjct: 1105 VNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCR 1164 Query: 1031 EAEHKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHR 1084 +H+ + ERD + D +KV +E E + + + R S E +R T+ R Sbjct: 1165 WRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSER 1224 Query: 1085 VDFIAKYLGGLREQEKRIK 1103 V+ ++ L + E+E +K Sbjct: 1225 VENMSMRLEEVNEREHSMK 1243 >gi|154091316 transient receptor potential cation channel, subfamily M, member 3 isoform e [Homo sapiens] Length = 1556 Score = 466 bits (1199), Expect = e-131 Identities = 343/1135 (30%), Positives = 563/1135 (49%), Gaps = 115/1135 (10%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH ++ ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211 V + L L+S SHFIL + G GK +LR +LEKHIS Q Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264 R G G +PV+ L+V G PN + + + P ++V GSG +D+LA Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225 Query: 265 ----ALVNQ---PHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317 L+N+ LLV +K F ++ +L + L+TV+ Sbjct: 226 SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276 Query: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377 EG +++D IL AL+K + + D+L LA+AW+RVDIA+S+IF +W Sbjct: 277 MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330 Query: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437 LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + S L R + Sbjct: 331 GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390 Query: 438 EARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFY--------------- 482 + G + PP SL ++ V++ + A R Y Sbjct: 391 KREYPGFGWIYFKGNLPP--DYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 448 Query: 483 -QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN----PWRDLFLWAVLQNRHEMATYF 537 +D P RR K KR ++ +DL+ N P+ +L +WAVL R +MA +F Sbjct: 449 KRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFF 504 Query: 538 WAMGQEGVAAALAACKILKEMSHLETEAEAARATRE------AKYERLALDLFSECYSNS 591 W G+E +A AL ACK+ K M+H +E + + + +LA++L + Y Sbjct: 505 WQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQD 564 Query: 592 EARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWG--DMAAGTPILR 649 E A LL + WS TCL LA A + F AH Q LT +W G M + + Sbjct: 565 EQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKV 624 Query: 650 LLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRVEELVEAP 707 +LG L P+++ ++ P + ++ LQ+ ++ + EK + +E Sbjct: 625 ILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLG 683 Query: 708 RAQGDRG-----------PRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVD 756 R G+ R + L + +F+ AP+ F + Y +L LF Y++LV Sbjct: 684 RNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVK 743 Query: 757 FRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIF 816 + PS E + ++FTL +E++R+ E L++K +++ + WN D++AI Sbjct: 744 ME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNVTDLIAIL 799 Query: 817 LFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFF 875 LF VG+ R+ F + GR + ++ + + +RL+ IF ++K LGP ++++ +MM D+ + Sbjct: 800 LFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMY 859 Query: 876 FLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEID-EARVNCS 934 F+ + V L+++GV QA+L P++ + + + Y PY I+G++ D+ID N + Sbjct: 860 FVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNET 919 Query: 935 THPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWK 994 + P C + W+V ++ +LLV N+LL+NLLIA+F+ TF V+ ++ WK Sbjct: 920 REDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWK 977 Query: 995 FQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD------LPDPLD 1048 FQRY LI+ +HERP L PP I+ SH+++ + + + +H+ + ERD + D Sbjct: 978 FQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDEL 1037 Query: 1049 QKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103 +KV +E E + + + R S E +R T+ RV+ ++ L + E+E +K Sbjct: 1038 KKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1092 >gi|154091318 transient receptor potential cation channel, subfamily M, member 3 isoform d [Homo sapiens] Length = 1544 Score = 466 bits (1198), Expect = e-131 Identities = 343/1137 (30%), Positives = 563/1137 (49%), Gaps = 131/1137 (11%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211 V + L L+S SHFIL + G GK +LR +LEKHIS Q Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264 R G G +PV+ L+V G PN + + + P ++V GSG +D+LA Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225 Query: 265 ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317 L+N+ LLV +K F ++ +L + L+TV+ Sbjct: 226 SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276 Query: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377 EG +++D IL AL+K + + D+L LA+AW+RVDIA+S+IF +W Sbjct: 277 MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330 Query: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437 LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + S L R + Sbjct: 331 GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390 Query: 438 EARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRGFY------------- 482 + L PP + SL ++ V++ + A R Y Sbjct: 391 KGNL----------------PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLF 434 Query: 483 ---QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN----PWRDLFLWAVLQNRHEMAT 535 +D P RR K KR ++ +DL+ N P+ +L +WAVL R +MA Sbjct: 435 GPKRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMAL 490 Query: 536 YFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLFSECYS 589 +FW G+E +A AL ACK+ K M+H +E + + + +LA++L + Y Sbjct: 491 FFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYK 550 Query: 590 NSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD--MAAGTPI 647 E A LL + WS TCL LA A + F AH Q LT +W G M + + Sbjct: 551 QDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL 610 Query: 648 LRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRVEELVE 705 +LG L P+++ ++ P + ++ LQ+ ++ + EK + +E Sbjct: 611 KVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAM 669 Query: 706 APRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLL 754 R G+ R + L + +F+ AP+ F + Y +L LF Y++L Sbjct: 670 LGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVL 729 Query: 755 VDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVA 814 V + PS E + ++FTL +E++R+ E L++K +++ + WN D++A Sbjct: 730 VKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNVTDLIA 785 Query: 815 IFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDV 873 I LF VG+ R+ F + GR + ++ + + +RL+ IF ++K LGP ++++ +MM D+ Sbjct: 786 ILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDM 845 Query: 874 FFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE-ARVN 932 +F+ + V L+++GV QA+L P++ + + + Y PY I+G++ D+ID N Sbjct: 846 MYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQN 905 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + P C + W+V ++ +LLV N+LL+NLLIA+F+ TF V+ ++ Sbjct: 906 ETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV 963 Query: 993 WKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD------LPDP 1046 WKFQRY LI+ +HERP L PP I+ SH+++ + + + +H+ + ERD + D Sbjct: 964 WKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDD 1023 Query: 1047 LDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103 +KV +E E + + + R S E +R T+ RV+ ++ L + E+E +K Sbjct: 1024 ELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1080 >gi|154091312 transient receptor potential cation channel, subfamily M, member 3 isoform b [Homo sapiens] Length = 1566 Score = 465 bits (1197), Expect = e-130 Identities = 344/1142 (30%), Positives = 561/1142 (49%), Gaps = 119/1142 (10%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211 V + L L+S SHFIL + G GK +LR +LEKHIS Q Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264 R G G +PV+ L+V G PN + + + P ++V GSG +D+LA Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225 Query: 265 ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317 L+N+ LLV +K F ++ +L + L+TV+ Sbjct: 226 SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276 Query: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377 EG +++D IL AL+K + + D+L LA+AW+RVDIA+S+IF +W Sbjct: 277 MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330 Query: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437 LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + S L R + Sbjct: 331 GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390 Query: 438 EARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGP 497 + G + PP SL ++ V++ + A R Y R GP Sbjct: 391 KREYPGFGWIYFKGNLPP--DYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 448 Query: 498 AKRPTGQKWL-----------------------LDLNQKSEN----PWRDLFLWAVLQNR 530 KRP K L +DL+ N P+ +L +WAVL R Sbjct: 449 -KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKR 507 Query: 531 HEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALDLF 584 +MA +FW G+E +A AL ACK+ K M+H +E + + + +LA++L Sbjct: 508 QKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELL 567 Query: 585 SECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD--MA 642 + Y E A LL + WS TCL LA A + F AH Q LT +W G M Sbjct: 568 DQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMR 627 Query: 643 AGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQSRV 700 + + +LG L P+++ ++ P + ++ LQ+ ++ + EK + + Sbjct: 628 KNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDM 686 Query: 701 EELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLF 749 E R G+ R + L + +F+ AP+ F + Y +L LF Sbjct: 687 ELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLF 746 Query: 750 TYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNK 809 Y++LV + PS E + ++FTL +E++R+ E L++K +++ + WN Sbjct: 747 NYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYWNV 802 Query: 810 CDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVER 868 D++AI LF VG+ R+ F + GR + ++ + + +RL+ IF ++K LGP ++++ + Sbjct: 803 TDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGK 862 Query: 869 MMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE 928 MM D+ +F+ + V L+++GV QA+L P++ + + + Y PY I+G++ D+ID Sbjct: 863 MMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDP 922 Query: 929 -ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQG 987 N + + P C + W+V ++ +LLV N+LL+NLLIA+F+ TF V+ Sbjct: 923 PCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKS 980 Query: 988 NADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD----- 1042 ++ WKFQRY LI+ +HERP L PP I+ SH+++ + + + +H+ + ERD Sbjct: 981 ISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKL 1040 Query: 1043 -LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKR 1101 + D +KV +E E + + + R S E +R T+ RV+ ++ L + E+E Sbjct: 1041 FITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHS 1100 Query: 1102 IK 1103 +K Sbjct: 1101 MK 1102 >gi|154091320 transient receptor potential cation channel, subfamily M, member 3 isoform a [Homo sapiens] Length = 1554 Score = 465 bits (1196), Expect = e-130 Identities = 344/1144 (30%), Positives = 561/1144 (49%), Gaps = 135/1144 (11%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211 V + L L+S SHFIL + G GK +LR +LEKHIS Q Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA----- 264 R G G +PV+ L+V G PN + + + P ++V GSG +D+LA Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKY 225 Query: 265 ----ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYD 317 L+N+ LLV +K F ++ +L + L+TV+ Sbjct: 226 SEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQHLFIILMECMKKKELITVFR 276 Query: 318 FEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKS 377 EG +++D IL AL+K + + D+L LA+AW+RVDIA+S+IF +W Sbjct: 277 MGSEGHQDIDLAILTALLKGANASAP------DQLSLALAWNRVDIARSQIFIYGQQWPV 330 Query: 378 CDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQE 437 LE+ M+DALV ++ +FV+L ++NG + FLT RL+ELY + S L R + Sbjct: 331 GSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVK 390 Query: 438 EARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEK 495 + L PP + SL ++ V++ + A R Y R Sbjct: 391 KGNL----------------PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLF 434 Query: 496 GPAKRPTGQKWL-----------------------LDLNQKSEN----PWRDLFLWAVLQ 528 GP KRP K L +DL+ N P+ +L +WAVL Sbjct: 435 GP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLM 493 Query: 529 NRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA------KYERLALD 582 R +MA +FW G+E +A AL ACK+ K M+H +E + + + +LA++ Sbjct: 494 KRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVE 553 Query: 583 LFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD-- 640 L + Y E A LL + WS TCL LA A + F AH Q LT +W G Sbjct: 554 LLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR 613 Query: 641 MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSLDTEKSPLYGLQS 698 M + + +LG L P+++ ++ P + ++ LQ+ ++ + EK + Sbjct: 614 MRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEE 672 Query: 699 RVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLF 747 +E R G+ R + L + +F+ AP+ F + Y +L Sbjct: 673 DMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLM 732 Query: 748 LFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNW 807 LF Y++LV + PS E + ++FTL +E++R+ E L++K +++ + W Sbjct: 733 LFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKLLQKVKVWLQEYW 788 Query: 808 NKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVV 866 N D++AI LF VG+ R+ F + GR + ++ + + +RL+ IF ++K LGP ++++ Sbjct: 789 NVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMI 848 Query: 867 ERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEI 926 +MM D+ +F+ + V L+++GV QA+L P++ + + + Y PY I+G++ D+I Sbjct: 849 GKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQI 908 Query: 927 DE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVV 985 D N + + P C + W+V ++ +LLV N+LL+NLLIA+F+ TF V Sbjct: 909 DPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEV 966 Query: 986 QGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERD--- 1042 + ++ WKFQRY LI+ +HERP L PP I+ SH+++ + + + +H+ + ERD Sbjct: 967 KSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGL 1026 Query: 1043 ---LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQE 1099 + D +KV +E E + + + R S E +R T+ RV+ ++ L + E+E Sbjct: 1027 KLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNERE 1086 Query: 1100 KRIK 1103 +K Sbjct: 1087 HSMK 1090 >gi|154091310 transient receptor potential cation channel, subfamily M, member 3 isoform g [Homo sapiens] Length = 1569 Score = 460 bits (1184), Expect = e-129 Identities = 343/1156 (29%), Positives = 565/1156 (48%), Gaps = 144/1156 (12%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAG- 214 V + L L+S SHFIL + G GK +LR +LEKHIS Q+ Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 215 -------------YGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252 Y GS + +PV+ L+V G PN + + + P + Sbjct: 172 RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231 Query: 253 LV--GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVR 298 +V GSG +D+LA L+N+ LLV +K F ++ Sbjct: 232 VVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQH 282 Query: 299 WTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAW 358 +L + L+TV+ EG +++D IL AL+K + + D+L LA+AW Sbjct: 283 LFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAW 336 Query: 359 DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418 +RVDIA+S+IF +W LE+ M+DALV ++ +FV+L ++NG + FLT RL+EL Sbjct: 337 NRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEEL 396 Query: 419 YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476 Y + S L R ++ L PP + SL ++ V++ + Sbjct: 397 YNTRHGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGG 440 Query: 477 ACRGFY----------------QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSEN---- 516 A R Y +D P RR K KR ++ +DL+ N Sbjct: 441 AYRCNYTRKRFRTLYHNLFGPKRDDIP--LRRGRKTTKKRE--EEVDIDLDDPEINHFPF 496 Query: 517 PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREA-- 574 P+ +L +WAVL R +MA +FW G+E +A AL ACK+ K M+H +E + + Sbjct: 497 PFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELN 556 Query: 575 ----KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQ 630 + +LA++L + Y E A LL + WS TCL LA A + F AH Q Sbjct: 557 HNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQ 616 Query: 631 AFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED--LQDLDSL 686 LT +W G M + + +LG L P+++ ++ P + ++ LQ+ ++ Sbjct: 617 MLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIHLQEKEAE 675 Query: 687 DTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFWGAPVTVF 735 + EK + +E R G+ R + L + +F+ AP+ F Sbjct: 676 EPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKF 735 Query: 736 LGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHL 795 + Y +L LF Y++LV + PS E + ++FTL +E++R+ E L Sbjct: 736 WFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-ILMSEPGKL 791 Query: 796 VKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFA 854 ++K +++ + WN D++AI LF VG+ R+ F + GR + ++ + + +RL+ IF Sbjct: 792 LQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFG 851 Query: 855 IHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPY 914 ++K LGP ++++ +MM D+ +F+ + V L+++GV QA+L P++ + + + Y PY Sbjct: 852 VNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPY 911 Query: 915 LQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNL 973 I+G++ D+ID N + + P C + W+V ++ +LLV N+LL+NL Sbjct: 912 WMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVANILLVNL 969 Query: 974 LIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAE 1033 LIA+F+ TF V+ ++ WKFQRY LI+ +HERP L PP I+ SH+++ + + + + Sbjct: 970 LIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRK 1029 Query: 1034 HKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDF 1087 H+ + ERD + D +KV +E E + + + R S E +R T+ RV+ Sbjct: 1030 HESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVEN 1089 Query: 1088 IAKYLGGLREQEKRIK 1103 ++ L + E+E +K Sbjct: 1090 MSMRLEEVNEREHSMK 1105 >gi|154091308 transient receptor potential cation channel, subfamily M, member 3 isoform f [Homo sapiens] Length = 1579 Score = 459 bits (1182), Expect = e-129 Identities = 344/1163 (29%), Positives = 563/1163 (48%), Gaps = 148/1163 (12%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH+ + ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHA---SKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAG- 214 V + L L+S SHFIL + G GK +LR +LEKHIS Q+ Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 215 -------------YGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252 Y GS + +PV+ L+V G PN + + + P + Sbjct: 172 RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231 Query: 253 LV--GSGGIADVLA---------ALVNQP---HLLVPKVAEKQFKEKFPSKHFSWEDIVR 298 +V GSG +D+LA L+N+ LLV +K F ++ Sbjct: 232 VVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLV--TIQKTFT-------YTRTQAQH 282 Query: 299 WTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAW 358 +L + L+TV+ EG +++D IL AL+K + + D+L LA+AW Sbjct: 283 LFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP------DQLSLALAW 336 Query: 359 DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418 +RVDIA+S+IF +W LE+ M+DALV ++ +FV+L ++NG + FLT RL+EL Sbjct: 337 NRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEEL 396 Query: 419 YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476 Y + S L R ++ L PP + SL ++ V++ + Sbjct: 397 YNTRHGPSNTLYHLVRDVKKGNL----------------PPDYRISLIDIGLVIEYLMGG 440 Query: 477 ACRGFYQDGRPGDRRRAEKGPAKRPTGQKWL-----------------------LDLNQK 513 A R Y R GP KRP K L +DL+ Sbjct: 441 AYRCNYTRKRFRTLYHNLFGP-KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDP 499 Query: 514 SEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR 569 N P+ +L +WAVL R +MA +FW G+E +A AL ACK+ K M+H +E + Sbjct: 500 EINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVD 559 Query: 570 ATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAF 623 + + +LA++L + Y E A LL + WS TCL LA A + F Sbjct: 560 DISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDF 619 Query: 624 FAHDGVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLED-- 679 AH Q LT +W G M + + +LG L P+++ ++ P + ++ Sbjct: 620 IAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKN-KDDMPYMSQAQEIH 678 Query: 680 LQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----------RAVFLLTRWRKFW 728 LQ+ ++ + EK + +E R G+ R + L + +F+ Sbjct: 679 LQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFY 738 Query: 729 GAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFF 788 AP+ F + Y +L LF Y++LV + PS E + ++FTL +E++R+ Sbjct: 739 NAPIVKFWFYTLAYIGYLMLFNYIVLVKME---RWPSTQEWIVISYIFTLGIEKMRE-IL 794 Query: 789 TDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTL 847 E L++K +++ + WN D++AI LF VG+ R+ F + GR + ++ + + + Sbjct: 795 MSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYI 854 Query: 848 RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFR 907 RL+ IF ++K LGP ++++ +MM D+ +F+ + V L+++GV QA+L P++ + + Sbjct: 855 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 914 Query: 908 RVLYRPYLQIFGQIPLDEIDE-ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVT 966 + Y PY I+G++ D+ID N + + P C + W+V ++ +LLV Sbjct: 915 NIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKT--GAWIVPAIMACYLLVA 972 Query: 967 NVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRR 1026 N+LL+NLLIA+F+ TF V+ ++ WKFQRY LI+ +HERP L PP I+ SH+++ + Sbjct: 973 NILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQH 1032 Query: 1027 VFKKEAEHKREHLERD------LPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK 1080 + + +H+ + ERD + D +KV +E E + + + R S E +R Sbjct: 1033 LCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRV 1092 Query: 1081 TAHRVDFIAKYLGGLREQEKRIK 1103 T+ RV+ ++ L + E+E +K Sbjct: 1093 TSERVENMSMRLEEVNEREHSMK 1115 >gi|18921093 transient receptor potential cation channel, subfamily M, member 6 [Homo sapiens] Length = 2022 Score = 427 bits (1099), Expect = e-119 Identities = 336/1164 (28%), Positives = 556/1164 (47%), Gaps = 103/1164 (8%) Query: 26 GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84 G +NF G K++R L L+L EW + P LV+S+ G Q F M S Sbjct: 96 GTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKF 155 Query: 85 RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144 +++ +GLVKAA++TGAWI+T + G+++HVG A++ HS S ++ VG+ G Sbjct: 156 KEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLR---KIWTVGIPPWGV 212 Query: 145 VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRL 204 + ++R L +D Y D L +L+S SHFIL + G GK +LR L Sbjct: 213 IENQRDL--IGKDVVCLYQTLDN-PLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNL 269 Query: 205 EKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLA 264 EK++S Q+ + PV+ L+V G PN + + V+ P ++ G+G AD+LA Sbjct: 270 EKYLSLQKIHCRSRQGV--PVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLA 327 Query: 265 ALVNQPHLLVPKVAEKQFKEKF-----PSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFE 319 HL + Q KE+ + +FS + ++L H+ +T++D + Sbjct: 328 --FTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDAD 385 Query: 320 QEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379 E ++LD IL AL+K + E +L LA+AWDRVDIAK I + WK Sbjct: 386 SEEQQDLDLAILTALLKGTNLSASE------QLNLAMAWDRVDIAKKHILIYEQHWKPDA 439 Query: 380 LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVS--RKSLLFDLLQRKQE 437 LE+ M DALV ++ +FV+L ++ G ++ FLT RL+ELY + +LL L+Q ++ Sbjct: 440 LEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQ 499 Query: 438 EA-----RLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGF-YQDGRPGDRR 491 R+TL +G E G A+ + + + + R + +Q G+R Sbjct: 500 HTLLSGYRITLIDIGL--VVEYLIGR-AYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRN 556 Query: 492 RAEKG-----------PAKRPTGQKWLLDLNQKSEN--------------PWRDLFLWAV 526 + + P K L +KS+ P+ DL +WAV Sbjct: 557 ESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAV 616 Query: 527 LQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR-ATREAK-----YERLA 580 L R +MA +FW G+E A+ AC + + M+H E+ A+ E K + +LA Sbjct: 617 LMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLA 676 Query: 581 LDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD 640 LDL + + +E A LL R WS +TCL LA + F +H Q LT +W G Sbjct: 677 LDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGR 736 Query: 641 MAAG-TPILRLLGAFLCPALVYT---------NLITFSEEAPLRTGLEDLQDLDSLDTEK 690 + L+++ + + P + T + + S++ D S ++ Sbjct: 737 LKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESAS 796 Query: 691 SPLYGLQSRVEELVEAPRAQG-DRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLF 749 Y L+ +E ++ + G + G + + + +F+ AP+ F + Y AFL LF Sbjct: 797 VKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLF 856 Query: 750 TYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNK 809 TY +LV+ +P P S E + ++FT +E +R+ E +K +++ + WN Sbjct: 857 TYTVLVEMQPQP---SVQEWLVSIYIFTNAIEVVRE-ICISEPGKFTQKVKVWISEYWNL 912 Query: 810 CDMVAIFLFIVGVTCRMLPSAFE-AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVER 868 + VAI LF G R F AGR + +D + + RL+ FA+++ GP + ++ + Sbjct: 913 TETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAK 972 Query: 869 MMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE 928 M ++F+ + +++ L+++GV +A+L P + + R +++ PY I+G++ EID Sbjct: 973 MTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV 1032 Query: 929 ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGN 988 CS+ P SCP ++L L +L V ++++NLLIA F+ + ++ Sbjct: 1033 ----CSSQP-------SCPP--GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESI 1079 Query: 989 ADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLD 1048 ++ WK+ RY I+ YHE+P L PP ILLSH+ L LRR+ A H +E + L L Sbjct: 1080 SNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLS 1139 Query: 1049 QKVVT-----WETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103 ++ + E ++ F KME E E +R T+ RV + L + E+ IK Sbjct: 1140 KEDLKKLHDFEEQCVEKYFHEKMEDVNCSCE-ERIRVTSERVTEMYFQLKEMNEKVSFIK 1198 Query: 1104 ----CLESQINYCSVLVSSVADVL 1123 L+SQ+ + L + D L Sbjct: 1199 DSLLSLDSQVGHLQDLSALTVDTL 1222 >gi|148612863 transient receptor potential cation channel, subfamily M, member 7 [Homo sapiens] Length = 1865 Score = 418 bits (1074), Expect = e-116 Identities = 333/1192 (27%), Positives = 562/1192 (47%), Gaps = 132/1192 (11%) Query: 26 GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84 G +NF GGS R K+VR+ P V+ LLL EW + P LV+S+ G Q F + + Sbjct: 93 GVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRI 152 Query: 85 RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144 + +L KGL+KAA +TGAWILT + G+A+HVG A+++H AS S++ ++ +G+A G Sbjct: 153 KQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEH--ASRSSR-KICTIGIAPWGV 209 Query: 145 VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLD--SNL-SHFILVEPGPPGKGDGLTELR 201 + +R L D Y PL L+ +NL SHFILV+ G GK LR Sbjct: 210 IENRNDL--VGRDVVAPYQT----LLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 263 Query: 202 LRLEKHISEQRAGYG-GTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGG 258 LEK I++QR G G +PV+ L+ G PN + + ++++ P ++V G+G Sbjct: 264 RELEKTINQQRIHARIGQG---VPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGR 320 Query: 259 IADVLAALVNQPHL--LVPKVAEKQFKEKFPSK-HFSWEDIVRWTKLLQNITSHQHLLTV 315 AD+LA + Q +P AE +F + + + L + L+TV Sbjct: 321 AADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITV 380 Query: 316 YDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEW 375 + + +++D IL AL+K + + D+L L +AWDRVDIAK+ +F +W Sbjct: 381 FHIGSDEHQDIDVAILTALLKGTNASA------FDQLILTLAWDRVDIAKNHVFVYGQQW 434 Query: 376 KSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKS--LLFDLLQ 433 LE+ M+DALV ++ FV+L ++NG + FLT RL+ELY + + +LF L++ Sbjct: 435 LVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVR 494 Query: 434 RKQE---------------------------------EARLTLAGLGTQQARE----PPA 456 ++ RL LG R + Sbjct: 495 DVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSS 554 Query: 457 GPPAFSLHEVSRVLKDFLQDACRGFY----QDGRPGDRRRAEKGPAKRPTGQKWLLDLNQ 512 P HE D + + Q RP E+G KR + ++D++ Sbjct: 555 TPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDE--IVDIDD 612 Query: 513 KSEN----PWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAA 568 P +L +WA L R MA + W G+E +A AL ACKI + M++ +++ Sbjct: 613 PETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLV 672 Query: 569 RATREA------KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKA 622 T E + +LA++L + + E A LL + WS +TCL LA + + Sbjct: 673 DDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRP 732 Query: 623 FFAHDGVQAFLTRIWWG--DMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDL 680 F AH Q L+ +W G +M + +L + PA++ T +E + + +D Sbjct: 733 FVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQS-QDA 791 Query: 681 QDLDSLDTEKSPLYGLQSRVEELV-----EAPRAQGDRGPRAVFLLTRWRK--------- 726 + D+E + Q+ EE+ E + G + + + +K Sbjct: 792 HQMTMDDSENN----FQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYA 847 Query: 727 FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786 F+ AP+ F N + Y FL L+T+V+LV Q PS E + ++FT +E++R+ Sbjct: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQME---QLPSVQEWIVIAYIFTYAIEKVRE- 903 Query: 787 FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPS----------AFEAGRT 836 F E + +K ++ D +N D +AI F +G R F AGR Sbjct: 904 IFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRL 963 Query: 837 VLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH 896 + ++ + + +RL+ A+++Q GP ++++ +M+ ++F+ + +++ L+++GV +A+L+ Sbjct: 964 IYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILY 1023 Query: 897 PHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956 PH+ + + +++ PY IFG++ EID N S P + WL Sbjct: 1024 PHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC-ANDSVIPQICGPG--------TWLTP 1074 Query: 957 LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFIL 1016 L +L V ++++NLLIA F+ + V+ +++ WK+QRY+ I+ YHE+P L PP I+ Sbjct: 1075 FLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLII 1134 Query: 1017 LSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVV-TWETVQKENFLSKMEKRRRDSEG 1075 LSH+ + K+ + K + DQK + +E E + ++ + + Sbjct: 1135 LSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSE 1194 Query: 1076 EVLRKTAHRVDFIA---KYLGGLREQEKR-IKCLESQINYCSVLVSSVADVL 1123 E +R T RV+ + K +G KR ++ L+SQI + L + D L Sbjct: 1195 ERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTL 1246 >gi|94538366 transient receptor potential cation channel, subfamily M, member 1 [Homo sapiens] Length = 1603 Score = 316 bits (809), Expect = 9e-86 Identities = 230/796 (28%), Positives = 393/796 (49%), Gaps = 84/796 (10%) Query: 359 DRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQEL 418 + D K E+ N W + LE+ M+DALV ++ +FV+L ++NG ++ FLT RL+EL Sbjct: 445 EETDPRKIELLN----WVNA-LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEEL 499 Query: 419 YRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAF--SLHEVSRVLKDFLQD 476 Y + LL R +++ L PP + SL ++ VL+ + Sbjct: 500 YNTRLGPPNTLHLLVRDVKKSNL----------------PPDYHISLIDIGLVLEYLMGG 543 Query: 477 ACR-------------GFYQDGRPG--------DRRRAEKGPAKRPTGQKWLLDLN---- 511 A R + RP D KG K+ ++ +D++ Sbjct: 544 AYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDP 603 Query: 512 --QKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR 569 + + P+ +L +WAVL R +MA + W G+E +A AL ACK+ K M+H +E++ Sbjct: 604 AVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVD 663 Query: 570 ATRE------AKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAF 623 + + +LAL+L + Y + E A LL + WS +TCL LA A + F Sbjct: 664 DISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDF 723 Query: 624 FAHDGVQAFLTRIWWGD--MAAGTPILRLLGAFLCPALVYTNLITFSEEA-PLRTGLEDL 680 AH Q LT +W G M + ++G L P +++ T+ + + ED Sbjct: 724 IAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENEDG 783 Query: 681 QDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVV 740 ++ + +T+ + G + EE + R++ + T+ +F+ AP+ F + Sbjct: 784 KEKEEENTDANADAGSRKGDEE-------NEHKKQRSIPIGTKICEFYNAPIVKFWFYTI 836 Query: 741 MYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFT 800 Y +L LF YV+LV PS E + ++ +L LE+IR+ E L +K Sbjct: 837 SYLGYLLLFNYVILVRM---DGWPSLQEWIVISYIVSLALEKIRE-ILMSEPGKLSQKIK 892 Query: 801 LYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEA-GRTVLAMDFMVFTLRLIHIFAIHKQL 859 +++ + WN D+VAI F++G R+ + GR + +D + + +R++ IF ++K L Sbjct: 893 VWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYL 952 Query: 860 GPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFG 919 GP ++++ +MM D+ +F+ + V L+++GV QA+LHP + + R + Y PY I+G Sbjct: 953 GPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYG 1012 Query: 920 QIPLDEID----EARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLI 975 ++ D+ID E C + E P + WL L+ +LLV N+LL+NLLI Sbjct: 1013 EVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLI 1072 Query: 976 AMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRV---FKKEA 1032 A+F+ TF V+ ++ WKFQRY LI+ +H+RP L PP I+LSH+ + + R+ +K+ Sbjct: 1073 AVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKR 1132 Query: 1033 EHKREHLERDL-----PDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDF 1087 E +E +R L + L + E +E+F K E ++ S E +R T+ RV+ Sbjct: 1133 EGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREK-EDEQQSSSDERIRVTSERVEN 1191 Query: 1088 IAKYLGGLREQEKRIK 1103 ++ L + E+E +K Sbjct: 1192 MSMRLEEINERETFMK 1207 Score = 153 bits (387), Expect = 8e-37 Identities = 115/363 (31%), Positives = 182/363 (50%), Gaps = 45/363 (12%) Query: 31 GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRK 90 GG + ++RV P L L++ +W L P L++S+ G Q F M+ L+ V K Sbjct: 63 GGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGK 122 Query: 91 GLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRI 150 GL+KAA +TGAWI T + G+ HVG A++DH S+ ++ RV A+G+A G V ++ Sbjct: 123 GLIKAAMTTGAWIFTGGVSTGVISHVGDALKDH---SSKSRGRVCAIGIAPWGIVENKED 179 Query: 151 LEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISE 210 L +D Y + L L+++ +HFIL + G GK +LR LEKHIS Sbjct: 180 L--VGKDVTRVY-QTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISL 236 Query: 211 Q----RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA 264 Q R G G +P++ L+V G PN + + +++ P +++ GSG +D+L+ Sbjct: 237 QKINTRLGQG------VPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILS 290 Query: 265 ---------ALVNQ---PHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHL 312 ++N+ LLV +K F H + I+ K + L Sbjct: 291 FAHKYCEEGGIINESLREQLLV--TIQKTFNYNKAQSHQLFAIIMECMK-------KKEL 341 Query: 313 LTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGD 372 +TV+ EG ++++ IL AL+K + D+L LA+AW+RVDIA+S+IF Sbjct: 342 VTVFRMGSEGQQDIEMAILTALLKGTNVSAP------DQLSLALAWNRVDIARSQIFVFG 395 Query: 373 VEW 375 W Sbjct: 396 PHW 398 >gi|45935368 transient receptor potential cation channel, subfamily M, member 3 isoform h [Homo sapiens] Length = 230 Score = 125 bits (314), Expect = 2e-28 Identities = 84/235 (35%), Positives = 122/235 (51%), Gaps = 26/235 (11%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH ++ ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQ---- 211 V + L L+S SHFIL + G GK +LR +LEKHIS Q Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 212 RAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILV--GSGGIADVLA 264 R G G +PV+ L+V G PN + + + P ++V GSG +D+LA Sbjct: 172 RIGQG------VPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILA 220 >gi|55953096 transient receptor potential cation channel, subfamily M, member 3 isoform c [Homo sapiens] Length = 255 Score = 120 bits (300), Expect = 1e-26 Identities = 84/254 (33%), Positives = 124/254 (48%), Gaps = 39/254 (15%) Query: 40 FVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQST 99 +VRV P +L L+ EW L P L++S+ G Q F ++ L+ V KGL+KAA +T Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61 Query: 100 GAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDF- 158 GAWI T + G+ RHVG A++DH ++ ++ ++ +G+A G V E QED Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDH---ASKSRGKICTIGIAPWGIV-------ENQEDLI 111 Query: 159 ---PVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHIS------ 209 V + L L+S SHFIL + G GK +LR +LEKHIS Sbjct: 112 GRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT 171 Query: 210 --------EQRAGYGGTGSIE---------IPVLCLLVNGDPNTLERISRAVEQAAPWLI 252 + R Y GS + +PV+ L+V G PN + + + P + Sbjct: 172 RCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 231 Query: 253 LV--GSGGIADVLA 264 +V GSG +D+LA Sbjct: 232 VVCDGSGRASDILA 245 >gi|6912736 transient receptor potential cation channel, subfamily C, member 5 [Homo sapiens] Length = 973 Score = 68.6 bits (166), Expect = 3e-11 Identities = 70/327 (21%), Positives = 133/327 (40%), Gaps = 65/327 (19%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786 P F+ + Y FLF+ +++ D P+ E + WV + EI++ Sbjct: 363 PFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEM 422 Query: 787 FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAG------------ 834 + FT Y+ D WN D L++ ++ +++ G Sbjct: 423 WDGG--------FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHP 474 Query: 835 ----RTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYG-- 888 + A+ ++ +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 475 TLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 534 Query: 889 -------VTTQALLHPH----------DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV 931 T+A+ P+ + +F L + +FG + Sbjct: 535 LNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLF-ETLQSLFWSVFGLLN--------- 584 Query: 932 NCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADM 991 L + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 585 -------LYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI 637 Query: 992 FWKFQRYNLIVEY-HERPALAPPFILL 1017 WKF R L + Y E L PPF ++ Sbjct: 638 EWKFARTKLWMSYFDEGGTLPPPFNII 664 >gi|209863032 transient receptor potential cation channel, subfamily C, member 4 isoform zeta [Homo sapiens] Length = 804 Score = 65.1 bits (157), Expect = 4e-10 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 189 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 248 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 249 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 297 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 298 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 357 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I L Sbjct: 358 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 408 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 409 -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 461 Query: 993 WKFQRYNLIVEYHERPALAP-PF 1014 WKF R L + Y E P PF Sbjct: 462 WKFARTKLWMSYFEEGGTLPTPF 484 >gi|209863030 transient receptor potential cation channel, subfamily C, member 4 isoform delta [Homo sapiens] Length = 836 Score = 65.1 bits (157), Expect = 4e-10 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I L Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 582 -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634 Query: 993 WKFQRYNLIVEYHERPALAP-PF 1014 WKF R L + Y E P PF Sbjct: 635 WKFARTKLWMSYFEEGGTLPTPF 657 >gi|209863026 transient receptor potential cation channel, subfamily C, member 4 isoform beta [Homo sapiens] Length = 893 Score = 65.1 bits (157), Expect = 4e-10 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I L Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 582 -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634 Query: 993 WKFQRYNLIVEYHERPALAP-PF 1014 WKF R L + Y E P PF Sbjct: 635 WKFARTKLWMSYFEEGGTLPTPF 657 >gi|209863024 transient receptor potential cation channel, subfamily C, member 4 isoform epsilon [Homo sapiens] Length = 982 Score = 65.1 bits (157), Expect = 4e-10 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I L Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 582 -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634 Query: 993 WKFQRYNLIVEYHERPALAP-PF 1014 WKF R L + Y E P PF Sbjct: 635 WKFARTKLWMSYFEEGGTLPTPF 657 >gi|7706747 transient receptor potential cation channel, subfamily C, member 4 isoform alpha [Homo sapiens] Length = 977 Score = 65.1 bits (157), Expect = 4e-10 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I L Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992 + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+ Sbjct: 582 -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634 Query: 993 WKFQRYNLIVEYHERPALAP-PF 1014 WKF R L + Y E P PF Sbjct: 635 WKFARTKLWMSYFEEGGTLPTPF 657 >gi|22547184 transient receptor potential cation channel, subfamily V, member 4 isoform a [Homo sapiens] Length = 871 Score = 58.2 bits (139), Expect = 5e-08 Identities = 83/347 (23%), Positives = 146/347 (42%), Gaps = 31/347 (8%) Query: 672 PLRTGLEDLQDLDSLDTEKSPLYGL--QSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWG 729 P+ + L DL LD+ E S L L S++E E + P L +WRKF Sbjct: 413 PVYSSLYDLSSLDTCGEEASVLEILVYNSKIENRHEMLAVE----PINELLRDKWRKFGA 468 Query: 730 APVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ 785 F NVV Y + +FT Y L P P + + L V TL + Sbjct: 469 VS---FYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLF- 524 Query: 786 GFFTDEDTHLVKKF----TLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMD 841 FFT+ +KK +L++ ++ + I+ +V V+ + + EA V+ Sbjct: 525 -FFTNIKDLFMKKCPGVNSLFIDGSFQL--LYFIYSVLVIVSAALYLAGIEAYLAVMVFA 581 Query: 842 FMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVTTQALLHPHDG 900 ++ + ++ K G I++++++ KD+F FL ++++ Y +LL+P Sbjct: 582 LVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCAN 641 Query: 901 ----RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVI 956 + V P + +D ++ L + S P ++ I Sbjct: 642 MKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVF-----I 696 Query: 957 LLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVE 1003 +LLVT++++T VLL+N+LIA+ T V + WK Q I++ Sbjct: 697 ILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 743 >gi|21735483 transient receptor potential cation channel, subfamily V, member 3 [Homo sapiens] Length = 790 Score = 51.6 bits (122), Expect = 4e-06 Identities = 34/146 (23%), Positives = 71/146 (48%), Gaps = 19/146 (13%) Query: 863 IIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLH--PHDGRLEWIFRRVLYRPYLQIFGQ 920 +++ + ++ DV FLF V+L+ +GV +L+ P D + +G Sbjct: 577 VMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNK------------DCSSYGS 624 Query: 921 IPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSY 980 ++ ++ L ++ + P L+ + LL+T++++T VLL+N+LIA+ Sbjct: 625 FSDAVLELFKLTIGLGDLNIQQNSKYPILF-----LFLLITYVILTFVLLLNMLIALMGE 679 Query: 981 TFQVVQGNADMFWKFQRYNLIVEYHE 1006 T + V ++ W+ QR I+E+ + Sbjct: 680 TVENVSKESERIWRLQRARTILEFEK 705 >gi|22547180 transient receptor potential cation channel, subfamily V, member 4 isoform b [Homo sapiens] Length = 811 Score = 51.2 bits (121), Expect = 6e-06 Identities = 69/297 (23%), Positives = 126/297 (42%), Gaps = 25/297 (8%) Query: 720 LLTRWRKFWGAPVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWV 775 L +WRKF F NVV Y + +FT Y L P P + + L V Sbjct: 399 LRDKWRKFGAVS---FYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEV 455 Query: 776 FTLVLEEIRQGFFTDEDTHLVKKF----TLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAF 831 TL + FFT+ +KK +L++ ++ + I+ +V V+ + + Sbjct: 456 ITLFTGVLF--FFTNIKDLFMKKCPGVNSLFIDGSFQL--LYFIYSVLVIVSAALYLAGI 511 Query: 832 EAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVT 890 EA V+ ++ + ++ K G I++++++ KD+F FL ++++ Y Sbjct: 512 EAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASA 571 Query: 891 TQALLHPHDGRL----EWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSC 946 +LL+P + V P + +D ++ L + S Sbjct: 572 LVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKY 631 Query: 947 PSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVE 1003 P ++ I+LLVT++++T VLL+N+LIA+ T V + WK Q I++ Sbjct: 632 PVVF-----IILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILD 683 >gi|5730102 transient receptor potential cation channel, subfamily C, member 6 [Homo sapiens] Length = 931 Score = 48.5 bits (114), Expect = 4e-05 Identities = 45/172 (26%), Positives = 76/172 (44%), Gaps = 15/172 (8%) Query: 848 RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFR 907 R+ +I ++ GP I + R +KD+F F+ + VA+ + L + G + Sbjct: 609 RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAF 668 Query: 908 RVLYRPYLQIFGQI-PLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVT 966 + + +F I L E+ +N + H + +Y +VI+LL Sbjct: 669 TTVEESFKTLFWAIFGLSEVKSVVINYN-HKFIENIGYVLYGVYNVTMVIVLL------- 720 Query: 967 NVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAP-PFILL 1017 N+LIAM + +FQ ++ +AD+ WKF R L Y E P PF L+ Sbjct: 721 -----NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLV 767 >gi|209863028 transient receptor potential cation channel, subfamily C, member 4 isoform gamma [Homo sapiens] Length = 828 Score = 47.0 bits (110), Expect = 1e-04 Identities = 62/297 (20%), Positives = 111/297 (37%), Gaps = 65/297 (21%) Query: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785 P F+ + Y FLFL ++ D P+ E + WV + EI+Q Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421 Query: 786 --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832 G D Y+ D WN D V L++ ++ +++ SA Sbjct: 422 WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470 Query: 833 -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887 + A+ + +LRLI +F + LGP I + RM+ D+ FLF + L+A+ Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530 Query: 888 ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932 G+T + + L + IFG I Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN---------- 580 Query: 933 CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNA 989 L + + ++ + T+ +++ V+L+N+LIAM + ++Q++ A Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631 >gi|9966865 transient receptor potential cation channel, subfamily C, member 7 [Homo sapiens] Length = 862 Score = 45.8 bits (107), Expect = 2e-04 Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 35/211 (16%) Query: 848 RLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVA--------YGVTTQALLHPHD 899 R+ +I ++ GP I + R +KD+F F+ + VA Y A +P Sbjct: 554 RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAF 613 Query: 900 GRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLL 959 +E F+ + + IFG L E+ +L D + + +L Sbjct: 614 TTVEESFKTLFW----SIFG---LSEVISV--------VLKYDHK-----FIENIGYVLY 653 Query: 960 VTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAP-PFILLS 1018 + + V+L+N+LIAM + ++Q ++ +AD+ WKF R L + Y + P PF L+ Sbjct: 654 GVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVP 713 Query: 1019 ------HLSLTLRRVFKKEAEHKREHLERDL 1043 +L + ++ K + K + E DL Sbjct: 714 SPKSFYYLIMRIKMCLIKLCKSKAKSCENDL 744 >gi|194733735 transient receptor potential cation channel, subfamily C, member 3 isoform a [Homo sapiens] Length = 921 Score = 45.4 bits (106), Expect = 3e-04 Identities = 45/180 (25%), Positives = 84/180 (46%), Gaps = 31/180 (17%) Query: 848 RLIHIFAIHKQLGPKIIVVERMMKDVF---------FFLFFLSVWLVAYGVTTQALLHPH 898 R+ +I ++ GP I + R +KD+F FF F + ++++ Y A ++ Sbjct: 625 RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL-YSYYLGAKVNAA 683 Query: 899 DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILL 958 +E F+ + + IFG L E+ T +L D + + +L Sbjct: 684 FTTVEESFKTLFW----SIFG---LSEV--------TSVVLKYDHK-----FIENIGYVL 723 Query: 959 LVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEY-HERPALAPPFILL 1017 + + V+L+N+LIAM + ++Q ++ ++D+ WKF R L + Y + L PPF L+ Sbjct: 724 YGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLV 783 >gi|4507687 transient receptor potential cation channel, subfamily C, member 3 isoform b [Homo sapiens] Length = 848 Score = 45.4 bits (106), Expect = 3e-04 Identities = 45/180 (25%), Positives = 84/180 (46%), Gaps = 31/180 (17%) Query: 848 RLIHIFAIHKQLGPKIIVVERMMKDVF---------FFLFFLSVWLVAYGVTTQALLHPH 898 R+ +I ++ GP I + R +KD+F FF F + ++++ Y A ++ Sbjct: 552 RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFIL-YSYYLGAKVNAA 610 Query: 899 DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILL 958 +E F+ + + IFG L E+ T +L D + + +L Sbjct: 611 FTTVEESFKTLFW----SIFG---LSEV--------TSVVLKYDHK-----FIENIGYVL 650 Query: 959 LVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEY-HERPALAPPFILL 1017 + + V+L+N+LIAM + ++Q ++ ++D+ WKF R L + Y + L PPF L+ Sbjct: 651 YGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLV 710 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.138 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 47,446,059 Number of Sequences: 37866 Number of extensions: 2278683 Number of successful extensions: 5959 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 43 Number of HSP's successfully gapped in prelim test: 13 Number of HSP's that attempted gapping in prelim test: 5731 Number of HSP's gapped (non-prelim): 111 length of query: 1165 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1052 effective length of database: 13,968,660 effective search space: 14695030320 effective search space used: 14695030320 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.