BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|169211037 PREDICTED: similar to mitogen-activated protein kinase 8 interacting protein 1 [Homo sapiens] (423 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|169211037 PREDICTED: similar to mitogen-activated protein kin... 865 0.0 gi|239740950 PREDICTED: similar to mitogen-activated protein kin... 837 0.0 gi|4885433 mitogen-activated protein kinase 8 interacting protei... 628 e-180 gi|6912492 mitogen-activated protein kinase 8 interacting protei... 335 5e-92 gi|7706537 mitogen-activated protein kinase 8 interacting protei... 335 5e-92 gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 61 2e-09 gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein i... 43 5e-04 gi|50511947 cajalin 2 isoform b [Homo sapiens] 42 8e-04 gi|50511945 cajalin 2 isoform a [Homo sapiens] 42 8e-04 gi|10047134 cajalin 2 isoform c [Homo sapiens] 42 8e-04 gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 42 0.001 gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 41 0.002 gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 39 0.007 gi|10863899 numb homolog (Drosophila)-like [Homo sapiens] 39 0.009 gi|194473700 Src homology 3 domain-containing guanine nucleotide... 39 0.009 gi|90403598 mesoderm posterior 2 homolog [Homo sapiens] 37 0.026 gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 37 0.044 gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 37 0.044 gi|54144629 numb homolog isoform 4 [Homo sapiens] 37 0.044 gi|20070356 numb homolog isoform 3 [Homo sapiens] 37 0.044 gi|50083291 amyloid beta A4 precursor protein-binding, family B,... 36 0.058 gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 36 0.075 gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 36 0.075 gi|153070260 myristoylated alanine-rich protein kinase C substra... 35 0.098 gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 35 0.098 gi|11321634 CD2-associated protein [Homo sapiens] 35 0.13 gi|54144627 numb homolog isoform 2 [Homo sapiens] 35 0.13 gi|54144625 numb homolog isoform 1 [Homo sapiens] 35 0.13 gi|132626790 low density lipoprotein receptor adaptor protein 1 ... 35 0.17 gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens] 35 0.17 >gi|169211037 PREDICTED: similar to mitogen-activated protein kinase 8 interacting protein 1 [Homo sapiens] Length = 423 Score = 865 bits (2235), Expect = 0.0 Identities = 423/423 (100%), Positives = 423/423 (100%) Query: 1 MLQMDLIDATGDTPGAEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 60 MLQMDLIDATGDTPGAEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG Sbjct: 1 MLQMDLIDATGDTPGAEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 60 Query: 61 DTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKSRHLHQQPTLLELVSLRPCFRDYSDESD 120 DTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKSRHLHQQPTLLELVSLRPCFRDYSDESD Sbjct: 61 DTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKSRHLHQQPTLLELVSLRPCFRDYSDESD 120 Query: 121 SAIVYDNCASVSSPYESAIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGR 180 SAIVYDNCASVSSPYESAIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGR Sbjct: 121 SAIVYDNCASVSSPYESAIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGR 180 Query: 181 SRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEA 240 SRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEA Sbjct: 181 SRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEA 240 Query: 241 YNMRTGARGIFTAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSA 300 YNMRTGARGIFTAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSA Sbjct: 241 YNMRTGARGIFTAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSA 300 Query: 301 AMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADDSQEAKGNKCSHFFQLKNISFRG 360 AMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADDSQEAKGNKCSHFFQLKNISFRG Sbjct: 301 AMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADDSQEAKGNKCSHFFQLKNISFRG 360 Query: 361 YHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTENI 420 YHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTENI Sbjct: 361 YHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTENI 420 Query: 421 YLE 423 YLE Sbjct: 421 YLE 423 >gi|239740950 PREDICTED: similar to mitogen-activated protein kinase 8 interacting protein 1 [Homo sapiens] Length = 442 Score = 837 bits (2162), Expect = 0.0 Identities = 418/442 (94%), Positives = 420/442 (95%), Gaps = 19/442 (4%) Query: 1 MLQMDLIDATGDTPGAE---EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 57 MLQMDLIDATGDTPGAE EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP Sbjct: 1 MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60 Query: 58 GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK---------SRHLHQQPTLL----- 103 GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK SRHLHQQPTLL Sbjct: 61 GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHA 120 Query: 104 --ELVSLRPCFRDYSDESDSAIVYDNCASVSSPYESAIGEEYEEASRPQPPACLSKDSTP 161 ELVSLRPCF DYSDESDSAIVYDNC SVSSPYESAIGEEYEEASRPQPPACLSKDSTP Sbjct: 121 QLELVSLRPCFGDYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTP 180 Query: 162 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 221 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL Sbjct: 181 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 240 Query: 222 EVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 281 EVDDPLLVELQAEDYWYEAYNMRTGARG FTAYYAIEVTKEPEHMAALAKNSDWVDQFRV Sbjct: 241 EVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 300 Query: 282 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADDSQE 341 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG+KADDSQE Sbjct: 301 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQE 360 Query: 342 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 401 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR Sbjct: 361 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 420 Query: 402 AFQQFHKQFVEYTCPTENIYLE 423 AFQQFHKQFVEYTCPTE+IYLE Sbjct: 421 AFQQFHKQFVEYTCPTEDIYLE 442 >gi|4885433 mitogen-activated protein kinase 8 interacting protein 1 [Homo sapiens] Length = 711 Score = 628 bits (1620), Expect = e-180 Identities = 322/406 (79%), Positives = 338/406 (83%), Gaps = 9/406 (2%) Query: 21 DEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG---DTYRPKRPTTLNLFPQV 77 D + AA AG P +E S +++ PG G P P P+ Sbjct: 312 DPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPP------PRA 365 Query: 78 QLSQDTLNNNSLGKKSRHLHQQPTLLELVSLRPCFRDYSDESDSAIVYDNCASVSSPYES 137 LS DT + K + + LELVSLRPCF DYSDESDSA VYDNCASVSSPYES Sbjct: 366 SLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYES 425 Query: 138 AIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIIN 197 AIGEEYEEA RPQPPACLS+DSTPDEPDVHFSKKFLN+FMSGRSRSSSAESFGLFSCIIN Sbjct: 426 AIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIIN 485 Query: 198 REEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAI 257 EEQEQTHR IFRFVPRHEDE ELEVDDPLLVELQAEDYWYEAYNMRTGARG+F AYYAI Sbjct: 486 GEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAI 545 Query: 258 EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNP 317 EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKG+ VL AAMQKIATTRRLTVHFNP Sbjct: 546 EVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNP 605 Query: 318 PSSCVLEISVRGVKIGIKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLA 377 PSSCVLEISVRGVKIG+KADDSQEAKGNKCSHFFQLKNISF GYHPKNNKYFGFITKH A Sbjct: 606 PSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPA 665 Query: 378 DHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTENIYLE 423 DHRFACHVFVSEDSTKALAESVGRAFQQF+KQFVEYTCPTE+IYLE Sbjct: 666 DHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE 711 Score = 180 bits (456), Expect = 2e-45 Identities = 90/95 (94%), Positives = 90/95 (94%), Gaps = 3/95 (3%) Query: 1 MLQMDLIDATGDTPGAE---EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 57 MLQMDLIDATGDTPGAE EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP Sbjct: 91 MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 150 Query: 58 GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK 92 GSGDTYRPKRPTTLNLFPQV SQDTLNNNSLGKK Sbjct: 151 GSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKK 185 >gi|6912492 mitogen-activated protein kinase 8 interacting protein 2 isoform 1 [Homo sapiens] Length = 824 Score = 335 bits (859), Expect = 5e-92 Identities = 171/330 (51%), Positives = 226/330 (68%), Gaps = 31/330 (9%) Query: 101 TLLELVSLRPCFR-DYSDESDSAIVYDNCASVSSPYESAIGEEYEEASRPQPPACL---- 155 T LELVSLR C + E DS EAS + A L Sbjct: 519 TQLELVSLRRCAGLGHDSEEDSG---------------------GEASEEEAGAALLGGG 557 Query: 156 --SKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVP 213 S D++PD PD+ FSKKFLN+F++ SRSSS ESFGLFSC++N EE+EQTHR +FRF+P Sbjct: 558 QVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIP 617 Query: 214 RHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALAKNS 273 RH DE EL+VDDP+LVE + +D+W+ +NMRTG RG+F A+YA V + + ++ Sbjct: 618 RHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSP 677 Query: 274 DWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG 333 WV++F V+FLGSV+VP H+G+ +L AAMQKIAT R+LTVH PP+SC LEIS+RGVK+ Sbjct: 678 CWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLS 737 Query: 334 IKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTK 393 + + +CSHFFQ+KNISF G HP+N+ YFGFITKH RFACHVFVS++S + Sbjct: 738 LSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMR 794 Query: 394 ALAESVGRAFQQFHKQFVEYTCPTENIYLE 423 +A+SVGRAF +++++ + Y CPTE+IYLE Sbjct: 795 PVAQSVGRAFLEYYQEHLAYACPTEDIYLE 824 Score = 32.7 bits (73), Expect = 0.64 Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 4/71 (5%) Query: 17 EEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQ 76 EEDD++E G + + G +P S + + G S + RPTTL L Sbjct: 89 EEDDEDEEEEEEEEEGDGEGQEGGDPGS--EAPAPGPLIPSPSVEEPHKHRPTTLRL--T 144 Query: 77 VQLSQDTLNNN 87 +QD+LNNN Sbjct: 145 TLGAQDSLNNN 155 >gi|7706537 mitogen-activated protein kinase 8 interacting protein 2 isoform 2 [Homo sapiens] Length = 797 Score = 335 bits (859), Expect = 5e-92 Identities = 171/330 (51%), Positives = 226/330 (68%), Gaps = 31/330 (9%) Query: 101 TLLELVSLRPCFR-DYSDESDSAIVYDNCASVSSPYESAIGEEYEEASRPQPPACL---- 155 T LELVSLR C + E DS EAS + A L Sbjct: 492 TQLELVSLRRCAGLGHDSEEDSG---------------------GEASEEEAGAALLGGG 530 Query: 156 --SKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVP 213 S D++PD PD+ FSKKFLN+F++ SRSSS ESFGLFSC++N EE+EQTHR +FRF+P Sbjct: 531 QVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIP 590 Query: 214 RHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALAKNS 273 RH DE EL+VDDP+LVE + +D+W+ +NMRTG RG+F A+YA V + + ++ Sbjct: 591 RHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSP 650 Query: 274 DWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG 333 WV++F V+FLGSV+VP H+G+ +L AAMQKIAT R+LTVH PP+SC LEIS+RGVK+ Sbjct: 651 CWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLS 710 Query: 334 IKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTK 393 + + +CSHFFQ+KNISF G HP+N+ YFGFITKH RFACHVFVS++S + Sbjct: 711 LSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMR 767 Query: 394 ALAESVGRAFQQFHKQFVEYTCPTENIYLE 423 +A+SVGRAF +++++ + Y CPTE+IYLE Sbjct: 768 PVAQSVGRAFLEYYQEHLAYACPTEDIYLE 797 Score = 32.7 bits (73), Expect = 0.64 Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 4/71 (5%) Query: 17 EEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQ 76 EEDD++E G + + G +P S + + G S + RPTTL L Sbjct: 62 EEDDEDEEEEEEEEEGDGEGQEGGDPGS--EAPAPGPLIPSPSVEEPHKHRPTTLRL--T 117 Query: 77 VQLSQDTLNNN 87 +QD+LNNN Sbjct: 118 TLGAQDSLNNN 128 >gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo sapiens] Length = 304 Score = 60.8 bits (146), Expect = 2e-09 Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGIKAD 337 + KFLGS +V KG V+ A++K+ R + V L+IS+ GVKI Sbjct: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81 Query: 338 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAE 397 E K + H QL ISF + + F FI K ++ C+VF SE + + Sbjct: 82 --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139 Query: 398 SVGRAFQQFHKQFVE 412 ++G+AF +++F+E Sbjct: 140 TIGQAFDLAYRKFLE 154 >gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein isoform 1 [Homo sapiens] Length = 506 Score = 43.1 bits (100), Expect = 5e-04 Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 21/151 (13%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPS----SCVLEISVRGVKIGI 334 F K++GS+ VP V + AAM RR+ F + + +SV GVK+ + Sbjct: 32 FEAKYVGSLDVPRPNSRVEIVAAM------RRIRYEFKAKNIKKKKVSIMVSVDGVKVIL 85 Query: 335 KADDSQEAKGNKCSHFFQLK---------NISFRGYHPKNNKYFGFITKHLADHRFACHV 385 K K + + K I + + ++ K F +I + A + F C+V Sbjct: 86 KKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNV 145 Query: 386 FVSEDSTKA--LAESVGRAFQQFHKQFVEYT 414 F S+ ++A + +VG+AF+ HK +++T Sbjct: 146 FKSKKKSQAMRIVRTVGQAFEVCHKLSLQHT 176 >gi|50511947 cajalin 2 isoform b [Homo sapiens] Length = 510 Score = 42.4 bits (98), Expect = 8e-04 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGIKAD 337 ++ +LGS+ + +G A K+ A ++ T + +L +S +GVK Sbjct: 312 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 366 Query: 338 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 395 +A +++NIS P++ F +ITK L + CHVF + D A + Sbjct: 367 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 424 Query: 396 AESVGRAFQ 404 ++G+AF+ Sbjct: 425 ILTLGQAFE 433 >gi|50511945 cajalin 2 isoform a [Homo sapiens] Length = 1248 Score = 42.4 bits (98), Expect = 8e-04 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGIKAD 337 ++ +LGS+ + +G A K+ A ++ T + +L +S +GVK Sbjct: 1062 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 1116 Query: 338 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 395 +A +++NIS P++ F +ITK L + CHVF + D A + Sbjct: 1117 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 1174 Query: 396 AESVGRAFQ 404 ++G+AF+ Sbjct: 1175 ILTLGQAFE 1183 >gi|10047134 cajalin 2 isoform c [Homo sapiens] Length = 414 Score = 42.4 bits (98), Expect = 8e-04 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGIKAD 337 ++ +LGS+ + +G A K+ A ++ T + +L +S +GVK Sbjct: 228 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 282 Query: 338 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 395 +A +++NIS P++ F +ITK L + CHVF + D A + Sbjct: 283 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 340 Query: 396 AESVGRAFQ 404 ++G+AF+ Sbjct: 341 ILTLGQAFE 349 >gi|140161500 ankyrin repeat and sterile alpha motif domain containing 1 [Homo sapiens] Length = 1134 Score = 41.6 bits (96), Expect = 0.001 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 12/128 (9%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338 + +LGS+ + +G A K+ R+ T H + +L I+ +GVK Sbjct: 942 YEANYLGSMLIKDLRGTESTQDACAKM---RKSTEHMKKIPTIILSITYKGVKF------ 992 Query: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVF--VSEDSTKALA 396 +A +++NIS P++ F +ITK L CHVF V + T + Sbjct: 993 -IDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEII 1051 Query: 397 ESVGRAFQ 404 ++G+AF+ Sbjct: 1052 LTLGQAFE 1059 >gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] Length = 888 Score = 40.8 bits (94), Expect = 0.002 Identities = 19/54 (35%), Positives = 29/54 (53%) Query: 208 IFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTK 261 I+ + PR EDE EL + LV + +D W++ +M T G+F Y VT+ Sbjct: 453 IYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTR 506 Score = 36.2 bits (82), Expect = 0.058 Identities = 16/49 (32%), Positives = 26/49 (53%) Query: 203 QTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIF 251 + HR + + P+ E E EL+ D + V + ED W++ R G G+F Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLF 880 >gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] Length = 882 Score = 39.3 bits (90), Expect = 0.007 Identities = 18/66 (27%), Positives = 34/66 (51%) Query: 208 IFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMA 267 ++ + P+ DE EL + V + +D W++ ++RTG G+F Y V++ P A Sbjct: 472 LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGA 531 Query: 268 ALAKNS 273 +N+ Sbjct: 532 GPPRNN 537 Score = 35.4 bits (80), Expect = 0.098 Identities = 16/49 (32%), Positives = 26/49 (53%) Query: 203 QTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIF 251 + +R + + P+ E E EL+ D + V + ED WY+ R G G+F Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLF 874 >gi|10863899 numb homolog (Drosophila)-like [Homo sapiens] Length = 609 Score = 38.9 bits (89), Expect = 0.009 Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 14/126 (11%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338 F V++LG V+V +G V A++K+ R +V VL +S G+++ DD Sbjct: 80 FPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSV------KSVLWVSADGLRV---VDD 130 Query: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 397 K ++ +SF +K F +I + R+ CH F++ +DS + L+ Sbjct: 131 ----KTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSH 186 Query: 398 SVGRAF 403 +VG AF Sbjct: 187 AVGCAF 192 >gi|194473700 Src homology 3 domain-containing guanine nucleotide exchange factor [Homo sapiens] Length = 871 Score = 38.9 bits (89), Expect = 0.009 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 4/62 (6%) Query: 211 FVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALA 270 F + DE L+V D +L+ + D WYE +R G RG ++ +E KE A + Sbjct: 800 FTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERG----WFPMECAKEITCQATID 855 Query: 271 KN 272 KN Sbjct: 856 KN 857 >gi|90403598 mesoderm posterior 2 homolog [Homo sapiens] Length = 397 Score = 37.4 bits (85), Expect = 0.026 Identities = 16/32 (50%), Positives = 20/32 (62%) Query: 29 PGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 60 P GP +A++ E +GQGQ QGQ QG G G Sbjct: 166 PDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQG 197 Score = 32.7 bits (73), Expect = 0.64 Identities = 15/34 (44%), Positives = 18/34 (52%) Query: 27 RRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 60 R P +AE + +GQGQ QGQ QG G G Sbjct: 168 RGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQG 201 >gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo sapiens] Length = 671 Score = 36.6 bits (83), Expect = 0.044 Identities = 18/55 (32%), Positives = 29/55 (52%) Query: 205 HRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEV 259 +R ++++ P++EDE EL D + V Q +D W+ + RT G F Y V Sbjct: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671 Score = 28.9 bits (63), Expect = 9.2 Identities = 13/32 (40%), Positives = 20/32 (62%), Gaps = 1/32 (3%) Query: 232 QAEDYWYEAYNMRTGARGIFTAYYAIEVTKEP 263 + + WYE TG +GIF A Y ++V++EP Sbjct: 486 KVNENWYEGRITGTGRQGIFPASY-VQVSREP 516 >gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo sapiens] Length = 329 Score = 36.6 bits (83), Expect = 0.044 Identities = 18/55 (32%), Positives = 29/55 (52%) Query: 205 HRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEV 259 +R ++++ P++EDE EL D + V Q +D W+ + RT G F Y V Sbjct: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329 Score = 28.9 bits (63), Expect = 9.2 Identities = 13/32 (40%), Positives = 20/32 (62%), Gaps = 1/32 (3%) Query: 232 QAEDYWYEAYNMRTGARGIFTAYYAIEVTKEP 263 + + WYE TG +GIF A Y ++V++EP Sbjct: 144 KVNENWYEGRITGTGRQGIFPASY-VQVSREP 174 >gi|54144629 numb homolog isoform 4 [Homo sapiens] Length = 592 Score = 36.6 bits (83), Expect = 0.044 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 14/126 (11%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338 F VK+LG V+V +G + A++++ T + V VL +S G+++ Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAV------KAVLWVSADGLRV------ 86 Query: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 397 + K ++ +SF ++ F +I + R+ CH F++ +D+ + L+ Sbjct: 87 -VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSH 145 Query: 398 SVGRAF 403 +VG AF Sbjct: 146 AVGCAF 151 >gi|20070356 numb homolog isoform 3 [Homo sapiens] Length = 640 Score = 36.6 bits (83), Expect = 0.044 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 14/126 (11%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338 F VK+LG V+V +G + A++++ T + V VL +S G+++ Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAV------KAVLWVSADGLRV------ 86 Query: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 397 + K ++ +SF ++ F +I + R+ CH F++ +D+ + L+ Sbjct: 87 -VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSH 145 Query: 398 SVGRAF 403 +VG AF Sbjct: 146 AVGCAF 151 >gi|50083291 amyloid beta A4 precursor protein-binding, family B, member 2 [Homo sapiens] Length = 736 Score = 36.2 bits (82), Expect = 0.058 Identities = 32/148 (21%), Positives = 72/148 (48%), Gaps = 12/148 (8%) Query: 273 SDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKI 332 ++ V +F V++LG + V G +L++A++ + T+ N + ++V + Sbjct: 562 TELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSS------NKEDWLSVNMNVADATV 615 Query: 333 GIKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDST 392 + ++ ++E +C +++ +SF G K+ F FI + RF CHVF E + Sbjct: 616 TVISEKNEEEVLVEC----RVRFLSFMGVG-KDVHTFAFIMD-TGNQRFECHVFWCEPNA 669 Query: 393 KALAESVGRAFQQFHKQFVEYTCPTENI 420 ++E+V A +++ + P++ + Sbjct: 670 GNVSEAVQAACMLRYQKCLVARPPSQKV 697 >gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo sapiens] Length = 628 Score = 35.8 bits (81), Expect = 0.075 Identities = 18/68 (26%), Positives = 39/68 (57%), Gaps = 2/68 (2%) Query: 199 EEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIE 258 E + + + F ++P+++DE EL+V D + V + E+ W+E + G G+F + + E Sbjct: 60 ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWE--GVLNGKTGMFPSNFIKE 117 Query: 259 VTKEPEHM 266 ++ E + + Sbjct: 118 LSGESDEL 125 >gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo sapiens] Length = 665 Score = 35.8 bits (81), Expect = 0.075 Identities = 18/68 (26%), Positives = 39/68 (57%), Gaps = 2/68 (2%) Query: 199 EEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIE 258 E + + + F ++P+++DE EL+V D + V + E+ W+E + G G+F + + E Sbjct: 97 ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWE--GVLNGKTGMFPSNFIKE 154 Query: 259 VTKEPEHM 266 ++ E + + Sbjct: 155 LSGESDEL 162 >gi|153070260 myristoylated alanine-rich protein kinase C substrate [Homo sapiens] Length = 332 Score = 35.4 bits (80), Expect = 0.098 Identities = 23/66 (34%), Positives = 28/66 (42%), Gaps = 6/66 (9%) Query: 7 IDATGDTPGAEEDDDEERAARRPGAGPPKAESGQEPASRG---QGQSQGQSQGPGSGDTY 63 + A G P A D EE AA GA P A EPA+ G S + + P G+ Sbjct: 58 LQANGSAPAA---DKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAA 114 Query: 64 RPKRPT 69 P PT Sbjct: 115 EPGSPT 120 >gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] Length = 1597 Score = 35.4 bits (80), Expect = 0.098 Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 1/74 (1%) Query: 211 FVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALA 270 + PR DE LE D ++V Q+ D W E + G RG F +E PE A Sbjct: 1521 YKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPV-QQVEFISNPEVRAQNL 1579 Query: 271 KNSDWVDQFRVKFL 284 K + V +++ + Sbjct: 1580 KEAHRVKTAKLQLV 1593 >gi|11321634 CD2-associated protein [Homo sapiens] Length = 639 Score = 35.0 bits (79), Expect = 0.13 Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%) Query: 196 INREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYY 255 I ++ +++ + +F ++P++EDE EL+V D + + + E+ W+ G+F + + Sbjct: 104 IKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWS--GTLNNKLGLFPSNF 161 Query: 256 A--IEVTKEPE 264 +EVT + E Sbjct: 162 VKELEVTDDGE 172 >gi|54144627 numb homolog isoform 2 [Homo sapiens] Length = 603 Score = 35.0 bits (79), Expect = 0.13 Identities = 30/131 (22%), Positives = 59/131 (45%), Gaps = 13/131 (9%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHF-----NPPSSCVLEISVRGVKIG 333 F VK+LG V+V +G + A++++ R+ F VL +S G+++ Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRV- 97 Query: 334 IKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDST 392 + K ++ +SF ++ F +I + R+ CH F++ +D+ Sbjct: 98 ------VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTG 151 Query: 393 KALAESVGRAF 403 + L+ +VG AF Sbjct: 152 ERLSHAVGCAF 162 >gi|54144625 numb homolog isoform 1 [Homo sapiens] Length = 651 Score = 35.0 bits (79), Expect = 0.13 Identities = 30/131 (22%), Positives = 59/131 (45%), Gaps = 13/131 (9%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHF-----NPPSSCVLEISVRGVKIG 333 F VK+LG V+V +G + A++++ R+ F VL +S G+++ Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRV- 97 Query: 334 IKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDST 392 + K ++ +SF ++ F +I + R+ CH F++ +D+ Sbjct: 98 ------VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTG 151 Query: 393 KALAESVGRAF 403 + L+ +VG AF Sbjct: 152 ERLSHAVGCAF 162 >gi|132626790 low density lipoprotein receptor adaptor protein 1 [Homo sapiens] Length = 308 Score = 34.7 bits (78), Expect = 0.17 Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 11/128 (8%) Query: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338 F +K+LG V KG+ + +AA+++I T + + L++S RG+ I D+ Sbjct: 48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKAS--GKKLQKVTLKVSPRGI---ILTDN 102 Query: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFV--SEDSTKALA 396 N+ + IS+ ++K F +I + + CH F+ +A+ Sbjct: 103 LT----NQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVT 158 Query: 397 ESVGRAFQ 404 +V +AF+ Sbjct: 159 LTVAQAFK 166 >gi|55769533 PRKC, apoptosis, WT1, regulator [Homo sapiens] Length = 340 Score = 34.7 bits (78), Expect = 0.17 Identities = 38/147 (25%), Positives = 58/147 (39%), Gaps = 16/147 (10%) Query: 10 TGDTPGAEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGD----TYRP 65 T PG +DE AA A PP+ + + +G+S G S G G R Sbjct: 99 TRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLRE 158 Query: 66 KRPTTLNLFPQVQLSQDTLNNNSLGKKSRH----LHQQPTLL-ELVSLRPCFRDYSDESD 120 KR +T + D ++ G+K R + QQ T+ E V+L D Sbjct: 159 KRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNL-------LDPGS 211 Query: 121 SAIVYDNCASVSSPYESAIGEEYEEAS 147 S ++ + +VS Y+S E+ S Sbjct: 212 SYLLQEPPRTVSGRYKSTTSVSEEDVS 238 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.390 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,914,856 Number of Sequences: 37866 Number of extensions: 859191 Number of successful extensions: 5059 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 69 Number of HSP's successfully gapped in prelim test: 94 Number of HSP's that attempted gapping in prelim test: 4788 Number of HSP's gapped (non-prelim): 324 length of query: 423 length of database: 18,247,518 effective HSP length: 105 effective length of query: 318 effective length of database: 14,271,588 effective search space: 4538364984 effective search space used: 4538364984 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.