Search of human proteins with 110735406

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110735406 protein tyrosine phosphatase, receptor type, U
isoform 2 precursor [Homo sapiens]
         (1442 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110735406 protein tyrosine phosphatase, receptor type, U isof...  2955   0.0  
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...  2937   0.0  
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...  2929   0.0  
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...  1783   0.0  
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...  1774   0.0  
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...  1581   0.0  
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...  1576   0.0  
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...  1540   0.0  
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...  1530   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   463   e-130
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   458   e-128
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   458   e-128
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   458   e-128
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   456   e-128
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   456   e-128
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   454   e-127
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   449   e-126
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   448   e-125
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   448   e-125
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   448   e-125
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   398   e-110
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   398   e-110
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   398   e-110
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   370   e-102
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   370   e-102
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   339   1e-92
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   333   7e-91
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   310   5e-84
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   310   5e-84
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   310   5e-84

>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score = 2955 bits (7661), Expect = 0.0
 Identities = 1442/1442 (100%), Positives = 1442/1442 (100%)

Query: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
            MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60

Query: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
            RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120

Query: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
            VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180

Query: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
            LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240

Query: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
            SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300

Query: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
            YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360

Query: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
            RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420

Query: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
            LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
            TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
            RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600

Query: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
            LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660

Query: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
            LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720

Query: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK 780
            IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK
Sbjct: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK 780

Query: 781  ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL 840
            ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL
Sbjct: 781  ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL 840

Query: 841  GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK 900
            GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK
Sbjct: 841  GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK 900

Query: 901  KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGP 960
            KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGP
Sbjct: 901  KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGP 960

Query: 961  KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE 1020
            KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE
Sbjct: 961  KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE 1020

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH
Sbjct: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
Sbjct: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
            CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR
Sbjct: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200

Query: 1201 DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL 1260
            DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL
Sbjct: 1201 DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL 1260

Query: 1261 VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ 1320
            VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ
Sbjct: 1261 VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ 1320

Query: 1321 NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG 1380
            NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG
Sbjct: 1321 NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG 1380

Query: 1381 GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE 1440
            GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE
Sbjct: 1381 GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE 1440

Query: 1441 SR 1442
            SR
Sbjct: 1441 SR 1442


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score = 2937 bits (7615), Expect = 0.0
 Identities = 1436/1442 (99%), Positives = 1436/1442 (99%), Gaps = 6/1442 (0%)

Query: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
            MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60

Query: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
            RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120

Query: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
            VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180

Query: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
            LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240

Query: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
            SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300

Query: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
            YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360

Query: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
            RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420

Query: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
            LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
            TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
            RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600

Query: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
            LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660

Query: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
            LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720

Query: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK 780
            IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK
Sbjct: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK 780

Query: 781  ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL 840
            ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL
Sbjct: 781  ATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLL 840

Query: 841  GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK 900
            GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK
Sbjct: 841  GGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKK 900

Query: 901  KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGP 960
            KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID      GYHRSNHFIATQGP
Sbjct: 901  KDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID------GYHRSNHFIATQGP 954

Query: 961  KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE 1020
            KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE
Sbjct: 955  KPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAE 1014

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH
Sbjct: 1015 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1074

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA
Sbjct: 1075 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1134

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
            CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR
Sbjct: 1135 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1194

Query: 1201 DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL 1260
            DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL
Sbjct: 1195 DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRL 1254

Query: 1261 VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ 1320
            VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ
Sbjct: 1255 VYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQ 1314

Query: 1321 NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG 1380
            NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG
Sbjct: 1315 NISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGG 1374

Query: 1381 GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE 1440
            GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE
Sbjct: 1375 GRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLE 1434

Query: 1441 SR 1442
            SR
Sbjct: 1435 SR 1436


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score = 2929 bits (7594), Expect = 0.0
 Identities = 1436/1452 (98%), Positives = 1436/1452 (98%), Gaps = 16/1452 (1%)

Query: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
            MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1    MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60

Query: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
            RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61   RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120

Query: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
            VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121  VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180

Query: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
            LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181  LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240

Query: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
            SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241  SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300

Query: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
            YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360

Query: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
            RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361  RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420

Query: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
            LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421  LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480

Query: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
            TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481  TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540

Query: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
            RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541  RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600

Query: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
            LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660

Query: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
            LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661  LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720

Query: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG------- 773
            IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG       
Sbjct: 721  IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS 780

Query: 774  ---KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 830
               KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
Sbjct: 781  YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 840

Query: 831  GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 890
            GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
Sbjct: 841  GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 900

Query: 891  FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHR 950
            FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID      GYHR
Sbjct: 901  FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID------GYHR 954

Query: 951  SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI 1010
            SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI
Sbjct: 955  SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI 1014

Query: 1011 MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST 1070
            MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST
Sbjct: 1015 MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST 1074

Query: 1071 PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY 1130
            PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY
Sbjct: 1075 PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY 1134

Query: 1131 IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE 1190
            IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE
Sbjct: 1135 IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE 1194

Query: 1191 CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL 1250
            CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL
Sbjct: 1195 CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL 1254

Query: 1251 QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE 1310
            QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE
Sbjct: 1255 QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE 1314

Query: 1311 DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1370
            DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG
Sbjct: 1315 DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1374

Query: 1371 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1430
            RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD
Sbjct: 1375 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1434

Query: 1431 VALEYLEGLESR 1442
            VALEYLEGLESR
Sbjct: 1435 VALEYLEGLESR 1446


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score = 1783 bits (4619), Expect = 0.0
 Identities = 864/1423 (60%), Positives = 1072/1423 (75%), Gaps = 20/1423 (1%)

Query: 24   AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
            A GCTF++       C+Y Q  YDDF+W  V        P ++P GSY++V++S H PG+
Sbjct: 33   AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89

Query: 84   RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
            +A +   ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG  GR W
Sbjct: 90   KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149

Query: 144  HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
             +AELAVSTFWPNEYQV+FEA +S  R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 150  LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209

Query: 204  QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
            QNA+FQC+A GR A   +  LQR++G  +P A  ++I+HRRF A+F L  V++ +QDLYR
Sbjct: 210  QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269

Query: 264  CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
            CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL  GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 270  CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329

Query: 324  YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
            YRM  G W E HAV+  TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 330  YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389

Query: 384  MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
            MR PK L  AEIQAR++ + WE LGYN+TRCHT+ V++CYHY  G  HN++  +C+  + 
Sbjct: 390  MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447

Query: 444  GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
               ++ + +L PY NV ++++LTNPEGRKE +E   QTDEDVP  +  +SL  T  E+ I
Sbjct: 448  KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507

Query: 504  FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
            FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 508  FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567

Query: 564  LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
             F +RA T KGFG A    +TTNISAP+  DY  + + L E+  TITVLLRPAQ +GAPI
Sbjct: 568  QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627

Query: 623  SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
            S YQ++VEE    R +RE G  +C+ VP+T++ A++ G  +YF AEL   +LPE  PFTV
Sbjct: 628  SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687

Query: 683  GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
            GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+  C+RIA KAA  E    + + +++
Sbjct: 688  GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747

Query: 742  SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
            ++ +  I GI AG + V ILLL  +I+I++K K     K A  N RQE THM++A+DRS+
Sbjct: 748  TDRVVKIAGISAG-ILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806

Query: 801  TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
             DQSTL  ++ L ++FMD H +S R +  S   T  SS L   PR  C    SPY TGQL
Sbjct: 807  ADQSTLHAEDPLSITFMDQHNFSPRYENHSA--TAESSRLLDVPRYLCEGTESPYQTGQL 864

Query: 861  HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
            HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG    WD  KK      +R   + AYD
Sbjct: 865  HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924

Query: 917  RHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEH 976
              RV L P+  DP++DYINANYIDI + R+GY R +H+IATQGP  E VYDFWRM+WQE 
Sbjct: 925  HSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQ 984

Query: 977  CSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
             + IVM+T LVEVGRVKC +YWP+D++ YGD K+  V+ E LAEYVVRTF LERRGY+  
Sbjct: 985  SACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1044

Query: 1037 HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV 1096
             EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+
Sbjct: 1045 REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1104

Query: 1097 MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT 1156
            MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA 
Sbjct: 1105 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA 1164

Query: 1157 YKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLP 1216
            Y +MIRID Q+NSS L++EFQTLNSVTP L  E+CSIA LPRN DKNR MD+LPPDRCLP
Sbjct: 1165 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1224

Query: 1217 FLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
            FLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T  DFWRLVYDYGCTSIVMLN+++
Sbjct: 1225 FLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD 1284

Query: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
             S     C QYWPE G  +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ
Sbjct: 1285 LSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQ 1341

Query: 1337 FLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLE 1394
            +L W+++R+ P SK++FL L+ +V+KWQ   E G+GRTI+HCLNGGGRSG FCA   V+E
Sbjct: 1342 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1401

Query: 1395 MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
            M++  N+VDVF A KTLRN KPNMVE  +QY FCYDVALEYLE
Sbjct: 1402 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score = 1774 bits (4594), Expect = 0.0
 Identities = 862/1423 (60%), Positives = 1068/1423 (75%), Gaps = 26/1423 (1%)

Query: 24   AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
            A GCTF++       C+Y Q  YDDF+W  V        P ++P GSY++V++S H PG+
Sbjct: 33   AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89

Query: 84   RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
            +A +   ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG  GR W
Sbjct: 90   KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149

Query: 144  HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
             +AELAVSTFWPNEYQV+FEA +S  R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 150  LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209

Query: 204  QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
            QNA+FQC+A GR A   +  LQR++G  +P A  ++I+HRRF A+F L  V++ +QDLYR
Sbjct: 210  QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269

Query: 264  CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
            CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL  GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 270  CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329

Query: 324  YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
            YRM  G W E HAV+  TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 330  YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389

Query: 384  MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
            MR PK L  AEIQAR++ + WE LGYN+TRCHT+ V++CYHY  G  HN++  +C+  + 
Sbjct: 390  MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447

Query: 444  GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
               ++ + +L PY NV ++++LTNPEGRKE +E   QTDEDVP  +  +SL  T  E+ I
Sbjct: 448  KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507

Query: 504  FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
            FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 508  FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567

Query: 564  LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
             F +RA T KGFG A    +TTNISAP+  DY  + + L E+  TITVLLRPAQ +GAPI
Sbjct: 568  QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627

Query: 623  SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
            S YQ++VEE    R +RE G  +C+ VP+T++ A++ G  +YF AEL   +LPE  PFTV
Sbjct: 628  SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687

Query: 683  GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
            GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+  C+RIA KAA  E    + + +++
Sbjct: 688  GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747

Query: 742  SEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTK-ATVNYRQEKTHMMSAVDRSF 800
            ++ +  I GI A G+ V ILLL  +I+I++K K     K A  N RQE THM++A+DRS+
Sbjct: 748  TDRVVKIAGISA-GILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSY 806

Query: 801  TDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL 860
             DQSTL  ++ L ++FMD H +S R +  S   T  SS L   PR  C    SPY TGQL
Sbjct: 807  ADQSTLHAEDPLSITFMDQHNFSPRYENHS--ATAESSRLLDVPRYLCEGTESPYQTGQL 864

Query: 861  HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 916
            HPA+RVADLLQHIN MKT++ YGFK+EYESFFEG    WD  KK      +R   + AYD
Sbjct: 865  HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYD 924

Query: 917  RHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEH 976
              RV L P+  DP++DYINANYID      GY R +H+IATQGP  E VYDFWRM+WQE 
Sbjct: 925  HSRVILQPVEDDPSSDYINANYID------GYQRPSHYIATQGPVHETVYDFWRMIWQEQ 978

Query: 977  CSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
             + IVM+T LVEVGRVKC +YWP+D++ YGD K+  V+ E LAEYVVRTF LERRGY+  
Sbjct: 979  SACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038

Query: 1037 HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDV 1096
             EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV+D+
Sbjct: 1039 REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1098

Query: 1097 MLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKAT 1156
            MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EFKA 
Sbjct: 1099 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA 1158

Query: 1157 YKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLP 1216
            Y +MIRID Q+NSS L++EFQTLNSVTP L  E+CSIA LPRN DKNR MD+LPPDRCLP
Sbjct: 1159 YFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLP 1218

Query: 1217 FLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
            FLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T  DFWRLVYDYGCTSIVMLN+++
Sbjct: 1219 FLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD 1278

Query: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
             S     C QYWPE G  +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+ FQ
Sbjct: 1279 LSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQ 1335

Query: 1337 FLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACATVLE 1394
            +L W+++R+ P SK++FL L+ +V+KWQ   E G+GRTI+HCLNGGGRSG FCA   V+E
Sbjct: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395

Query: 1395 MIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
            M++  N+VDVF A KTLRN KPNMVE  +QY FCYDVALEYLE
Sbjct: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score = 1581 bits (4094), Expect = 0.0
 Identities = 771/1449 (53%), Positives = 1019/1449 (70%), Gaps = 53/1449 (3%)

Query: 21   ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
            ET + GC F+E   P   C YSQ++ DDF WEQV       +   +P GS+++VN S   
Sbjct: 21   ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77

Query: 81   PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
             GQRAH++   L ENDTHC+ F YF+ S+    PG L VYV+VN GPLG+ +WN++G   
Sbjct: 78   EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137

Query: 141  RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
            R W++AELA+STFWPN YQV+FE + S   +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 138  RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196

Query: 201  NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
            NAGQ A+FQC A GR    +R  LQ       P   ++  S RRF+A+F +   ++ +  
Sbjct: 197  NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256

Query: 261  LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
             YRC+ +   G G+SN+AEL+VKEPP PIAPPQL   G TYL IQLN NSI GDGPIV +
Sbjct: 257  KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316

Query: 321  EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
            E+EY  A G W +   V   +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 317  EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376

Query: 381  AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
            A+PMR P+ L   E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G    + +RE V 
Sbjct: 377  ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--QEQVREEVS 434

Query: 441  --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
              TE    ++TI NL PY NV V+L+L NPEGRKE +E+  QTDED+P  +  ES+  + 
Sbjct: 435  WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
             E+ IFL+W EP +  G+IT YEI+Y+++ S DP +++      +SKL NET+ +F  L+
Sbjct: 495  FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
            PGTTY F++RA T KGFG  A  + TT ISAPS    ++ +PL +++NT+TV+L+PA  R
Sbjct: 555  PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 619  GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
            GAP+SVYQ++VEEER RR ++      C+PVP+ F+ A      +YF AE  A SL  A 
Sbjct: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674

Query: 679  PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
            PFT+GDN+TY G+WN PL P K+Y IYFQAAS   GET+++C+++A K A      P E 
Sbjct: 675  PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733

Query: 739  SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV-NYRQEKTHMMSAVD 797
             ++++    I G+ AG L  +I+ LG ++++++K K     K T+ + RQE T M++++D
Sbjct: 734  EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792

Query: 798  RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------DQRSGGV 833
            +S+ +Q T  ++     SFMDTH  + R                         D+     
Sbjct: 793  KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMA 849

Query: 834  TEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFE 893
            ++ SSL+     +       PY TGQLHPA+RVADLLQHI QMK AEGYGFK+EYESFFE
Sbjct: 850  SDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFE 909

Query: 894  G----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYH 949
            G    WD+ KK +    +R   + AYD  RV+L  + GD N+DYIN NYID      GYH
Sbjct: 910  GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID------GYH 963

Query: 950  RSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIK 1009
            R NH+IATQGP  E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D++ Y DIK
Sbjct: 964  RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIK 1023

Query: 1010 IMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAS 1069
            + L++TE LAEYV+RTFA+E+RG     E+RQFHFT WP+HGVPYHATGLL F+R+VK+ 
Sbjct: 1024 VTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK 1083

Query: 1070 TPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQ 1129
            +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVNM+QTEEQ
Sbjct: 1084 SPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQ 1143

Query: 1130 YIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVE 1189
            Y+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN VTP L VE
Sbjct: 1144 YVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVE 1203

Query: 1190 ECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1249
            +CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +AFIVT HP
Sbjct: 1204 DCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHP 1263

Query: 1250 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1309
            L +T  DFWRLV DY CTS+VMLN +   + A  C QYWPE G  ++G ++VEF+S   +
Sbjct: 1264 LPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320

Query: 1310 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAE--S 1367
            ED+++R+FR+ N +R Q+G+ +V+ FQFL W  YRDTP SK++FL L+ +VDKWQ E   
Sbjct: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380

Query: 1368 GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHF 1427
            G+GRT+VHCLNGGGRSGTFCA + V EM+R    VDVF A KTLRN KPNMV+ +DQY F
Sbjct: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440

Query: 1428 CYDVALEYL 1436
            CY+VALEYL
Sbjct: 1441 CYEVALEYL 1449


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score = 1576 bits (4081), Expect = 0.0
 Identities = 771/1462 (52%), Positives = 1019/1462 (69%), Gaps = 66/1462 (4%)

Query: 21   ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
            ET + GC F+E   P   C YSQ++ DDF WEQV       +   +P GS+++VN S   
Sbjct: 21   ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77

Query: 81   PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
             GQRAH++   L ENDTHC+ F YF+ S+    PG L VYV+VN GPLG+ +WN++G   
Sbjct: 78   EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137

Query: 141  RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
            R W++AELA+STFWPN YQV+FE + S   +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 138  RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196

Query: 201  NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
            NAGQ A+FQC A GR    +R  LQ       P   ++  S RRF+A+F +   ++ +  
Sbjct: 197  NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256

Query: 261  LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
             YRC+ +   G G+SN+AEL+VKEPP PIAPPQL   G TYL IQLN NSI GDGPIV +
Sbjct: 257  KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316

Query: 321  EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
            E+EY  A G W +   V   +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 317  EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376

Query: 381  AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
            A+PMR P+ L   E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G    + +RE V 
Sbjct: 377  ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQ--EQVREEVS 434

Query: 441  --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
              TE    ++TI NL PY NV V+L+L NPEGRKE +E+  QTDED+P  +  ES+  + 
Sbjct: 435  WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
             E+ IFL+W EP +  G+IT YEI+Y+++ S DP +++      +SKL NET+ +F  L+
Sbjct: 495  FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
            PGTTY F++RA T KGFG  A  + TT ISAPS    ++ +PL +++NT+TV+L+PA  R
Sbjct: 555  PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 619  GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
            GAP+SVYQ++VEEER RR ++      C+PVP+ F+ A      +YF AE  A SL  A 
Sbjct: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674

Query: 679  PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
            PFT+GDN+TY G+WN PL P K+Y IYFQAAS   GET+++C+++A K A      P E 
Sbjct: 675  PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733

Query: 739  SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNY-RQEKTHMMSAVD 797
             ++++    I G+ AG L  +I+ LG ++++++K K     K T++  RQE T M++++D
Sbjct: 734  EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792

Query: 798  RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------------- 826
            +S+ +Q T  ++     SFMDTH  + R                                
Sbjct: 793  KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTA 849

Query: 827  ------DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAE 880
                  D+     ++ SSL+     +       PY TGQLHPA+RVADLLQHI QMK AE
Sbjct: 850  ILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAE 909

Query: 881  GYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINA 936
            GYGFK+EYESFFEG    WD+ KK +    +R   + AYD  RV+L  + GD N+DYIN 
Sbjct: 910  GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYING 969

Query: 937  NYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSR 996
            NYID      GYHR NH+IATQGP  E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +
Sbjct: 970  NYID------GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK 1023

Query: 997  YWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHA 1056
            YWP+D++ Y DIK+ L++TE LAEYV+RTFA+E+RG     E+RQFHFT WP+HGVPYHA
Sbjct: 1024 YWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHA 1083

Query: 1057 TGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTL 1116
            TGLL F+R+VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L
Sbjct: 1084 TGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143

Query: 1117 CSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEF 1176
             SRRVNM+QTEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF
Sbjct: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF 1203

Query: 1177 QTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDS 1236
            +TLN VTP L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DS
Sbjct: 1204 RTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDS 1263

Query: 1237 YTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQY 1296
            Y + +AFIVT HPL +T  DFWRLV DY CTS+VMLN +   + A  C QYWPE G  ++
Sbjct: 1264 YKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRH 1320

Query: 1297 GLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1356
            G ++VEF+S   +ED+++R+FR+ N +R Q+G+ +V+ FQFL W  YRDTP SK++FL L
Sbjct: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380

Query: 1357 LAEVDKWQAE--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNY 1414
            + +VDKWQ E   G+GRT+VHCLNGGGRSGTFCA + V EM+R    VDVF A KTLRN 
Sbjct: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440

Query: 1415 KPNMVETMDQYHFCYDVALEYL 1436
            KPNMV+ +DQY FCY+VALEYL
Sbjct: 1441 KPNMVDLLDQYKFCYEVALEYL 1462


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score = 1540 bits (3988), Expect = 0.0
 Identities = 752/1457 (51%), Positives = 1011/1457 (69%), Gaps = 40/1457 (2%)

Query: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57

Query: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117

Query: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177

Query: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237

Query: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297

Query: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357

Query: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417

Query: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533

Query: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593

Query: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653

Query: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713

Query: 715  ETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG- 773
            ET++NC+R+A K A  ++   +E  ++ +    + G+ AG L  +I+LLG ++ I R+  
Sbjct: 714  ETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRN 773

Query: 774  --------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTR 825
                    K     K T +  Q +   +++ D+  T  S  + DE    S  D +G++  
Sbjct: 774  AYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT-- 831

Query: 826  GDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFK 885
             D   G +++ +  +   P R C      Y   Q  PA+RVADLLQHI QMK  +GYGFK
Sbjct: 832  -DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890

Query: 886  QEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDI 941
            +EYE+  EG    WD  K+ +    +R   + +YD  RV+L  + GDP++DYINANYID 
Sbjct: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID- 949

Query: 942  RINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED 1001
                 GYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LVEVGRVKC RYWP+D
Sbjct: 950  -----GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD 1004

Query: 1002 SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLA 1061
            ++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+WP+HGVP +ATGLL 
Sbjct: 1005 TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLG 1064

Query: 1062 FIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRV 1121
            F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVDI+NCV+ L ++RV
Sbjct: 1065 FVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRV 1124

Query: 1122 NMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNS 1181
            N++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+NSSQ+++EFQTLN 
Sbjct: 1125 NLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNI 1184

Query: 1182 VTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSA 1241
            VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NYINAAL DS+ + A
Sbjct: 1185 VTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPA 1244

Query: 1242 AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEV 1301
            AF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QYWPE     YG ++V
Sbjct: 1245 AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYWPEKTSGCYGPIQV 1301

Query: 1302 EFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVD 1361
            EF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP SK++ L ++  ++
Sbjct: 1302 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1361

Query: 1362 KWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMV 1419
            KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF   KTLRN K NMV
Sbjct: 1362 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1421

Query: 1420 ETMDQYHFCYDVALEYL 1436
            ET++QY F Y+VALEYL
Sbjct: 1422 ETLEQYKFVYEVALEYL 1438


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score = 1530 bits (3962), Expect = 0.0
 Identities = 753/1476 (51%), Positives = 1012/1476 (68%), Gaps = 59/1476 (3%)

Query: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57

Query: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117

Query: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177

Query: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237

Query: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297

Query: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357

Query: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417

Query: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533

Query: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593

Query: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653

Query: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713

Query: 715  ETRLNCIRIARKA-------------------ACKESKRPLEVSQRSEEMGLILGICAGG 755
            ET++NC+R+A KA                   A  ++   +E  ++ +    + G+ AG 
Sbjct: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGL 773

Query: 756  LAVLILLLGAIIVIIRKG---------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTL 806
            L  +I+LLG ++ I R+          K     K T +  Q +   +++ D+  T  S  
Sbjct: 774  LMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSAS 833

Query: 807  QEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRV 866
            + DE    S  D +G++   D   G +++ +  +   P R C      Y   Q  PA+RV
Sbjct: 834  RNDEGFSSSSQDVNGFT---DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890

Query: 867  ADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKL 922
            ADLLQHI QMK  +GYGFK+EYE+  EG    WD  K+ +    +R   + +YD  RV+L
Sbjct: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950

Query: 923  HPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 982
              + GDP++DYINANYID      GYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM
Sbjct: 951  LVLDGDPHSDYINANYID------GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004

Query: 983  ITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQF 1042
            +T LVEVGRVKC RYWP+D++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R F
Sbjct: 1005 VTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064

Query: 1043 HFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE 1102
            HFT+WP+HGVP +ATGLL F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE
Sbjct: 1065 HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE 1124

Query: 1103 CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR 1162
             EGVVDI+NCV+ L ++RVN++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R
Sbjct: 1125 NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR 1184

Query: 1163 IDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTD 1222
            +DPQ+NSSQ+++EFQTLN VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS D
Sbjct: 1185 LDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD 1244

Query: 1223 GDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAW 1282
            G+S+NYINAAL DS+ + AAF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A 
Sbjct: 1245 GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQ 1301

Query: 1283 PCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSA 1342
             C+QYWPE     YG ++VEF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W A
Sbjct: 1302 FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPA 1361

Query: 1343 YRDTPDSKKAFLHLLAEVDKWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHN 1400
            YRDTP SK++ L ++  ++KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N
Sbjct: 1362 YRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQN 1421

Query: 1401 LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
            ++DVF   KTLRN K NMVET++QY F Y+VALEYL
Sbjct: 1422 IIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  463 bits (1191), Expect = e-130
 Identities = 358/1140 (31%), Positives = 525/1140 (46%), Gaps = 142/1140 (12%)

Query: 331  WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
            W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 463  WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 520

Query: 380  CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
             AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 521  -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 558

Query: 439  VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
            +  E G S Y ++ L P    + RL   +P+G   G      +   + S  A        
Sbjct: 559  ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 615

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 616  MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 662

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 663  PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 717

Query: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 718  PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 776

Query: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 777  YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 835

Query: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
                   P  ++   EE GLI  +    LAV+ ++   I +++ K KP            
Sbjct: 836  VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKSKP------------ 880

Query: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
                     DR   +                        D R   +     +    P  P
Sbjct: 881  ---------DRKRAES-----------------------DSRKSSIPNNKEIPSHHPTDP 908

Query: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 909  VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 968

Query: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 969  VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1022

Query: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1142

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1143 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1202

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1203 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1260

Query: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1261 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1318

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1319 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1377

Query: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1378 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1434

Query: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1494



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 297 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 352

Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 353 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 410

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 470

Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 471 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 516

Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 517 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 565

Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
            +    L P + Y F + AR+ +G G A+  EI+       F
Sbjct: 566 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 606



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 362 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 422 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 475

Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 528

Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 529 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 564


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  458 bits (1178), Expect = e-128
 Identities = 355/1140 (31%), Positives = 521/1140 (45%), Gaps = 146/1140 (12%)

Query: 331  WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
            W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 466  WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523

Query: 380  CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
             AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 524  -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561

Query: 439  VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
            +  E G S Y ++ L P    + RL   +P+G   G      +   + S  A        
Sbjct: 562  ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 618

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 619  MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 665

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 666  PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 720

Query: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 721  PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 779

Query: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 780  YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 838

Query: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 839  VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 882

Query: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
                                                   D R   +     +    P  P
Sbjct: 883  -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 907

Query: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 908  VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 967

Query: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 968  VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1021

Query: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1141

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1142 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1201

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1202 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1259

Query: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1260 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1317

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1318 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376

Query: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1377 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1433

Query: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1493



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355

Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473

Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519

Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568

Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
            +    L P + Y F + AR+ +G G A+  EI+       F
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 609



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478

Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531

Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  458 bits (1178), Expect = e-128
 Identities = 342/1084 (31%), Positives = 513/1084 (47%), Gaps = 129/1084 (11%)

Query: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 968

Query: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 969  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025

Query: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 1026 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1070

Query: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 1071 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127

Query: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 1128 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1185

Query: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1237

Query: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 1238 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1283

Query: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 1284 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1310

Query: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 1311 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1369

Query: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIAT 957
            +  +     +R   + AYD  RV L  + G P +DYINANYID      GY + N +IAT
Sbjct: 1370 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIAT 1423

Query: 958  QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTE 1016
            QGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T 
Sbjct: 1424 QGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTV 1483

Query: 1017 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1076
             LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP
Sbjct: 1484 ELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1543

Query: 1077 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1136
            +V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A
Sbjct: 1544 MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA 1603

Query: 1137 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1196
            +LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S            A L
Sbjct: 1604 LLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANL 1661

Query: 1197 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1253
            P N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +
Sbjct: 1662 PCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAES 1719

Query: 1254 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1313
            T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+       +
Sbjct: 1720 TEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1778

Query: 1314 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1372
             R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG  
Sbjct: 1779 LREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
             VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  A
Sbjct: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895

Query: 1433 LEYL 1436
            LEYL
Sbjct: 1896 LEYL 1899



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351

Query: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465

Query: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523

Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573

Query: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633

Query: 617 GRGAPISVYQVIVE----EERARRL 637
            R   I+ Y V  E    E+R R +
Sbjct: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 65/260 (25%), Positives = 103/260 (39%), Gaps = 17/260 (6%)

Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
           +Y L  L PDT Y     L    D G G   P + +RT  + P   P+ +    + +  +
Sbjct: 566 SYTLEDLKPDTLYRFQ--LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623

Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
            + W P   +         S+ Y    G    + + + +  E   S + +  L  +    
Sbjct: 624 RVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH--SSWDLVGLEKWTEYR 681

Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEPQEPNG 515
           V +      G   E   V  +TDEDVPSG    +  E L  T +   ++ K   P + +G
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVH--VYWKLPVPSKQHG 739

Query: 516 LITQYEISYQSIESSDP-----AVNVPGPRRTISKLRNETYH-VFSNLHPGTTYLFSVRA 569
            I  Y+++Y  +E+ +P       +V           +E Y    S L P TTY  +V A
Sbjct: 740 QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAA 799

Query: 570 RTGKGFGQAALTEITTNISA 589
            T KG G  +  +I T   A
Sbjct: 800 YTTKGDGARSKPKIVTTTGA 819



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 47/273 (17%)

Query: 316 PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLL-TRPGDGGTGRPGPPL 374
           PI++   +  +A   W    +   +T  +  L P+T Y ++V   T  GDG   +P    
Sbjct: 760 PIIQ---DVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAAYTTKGDGARSKPK--- 812

Query: 375 ISRTKCAEPMRAPKGLAFAEIQARQLTLQWEP--------LGYNVTRCHTYTVSLCYHYT 426
           I  T  A P R    ++   +      LQW P        LGY +  C            
Sbjct: 813 IVTTTGAVPGRPTMMISTTAMNTA--LLQWHPPKELPGELLGYRLQYCRA---------- 860

Query: 427 LGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVP 486
              +   TI +  K +Q    +T+  L        RL   N  G  E  E   +T ED+P
Sbjct: 861 -DEARPNTI-DFGKDDQ---HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 915

Query: 487 SGIAAESLTFTPLEDMIF-LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTI 543
           SG   ++L  T L      L W+ P   E NG I  Y + ++ I S     N+       
Sbjct: 916 SGFP-QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT------ 968

Query: 544 SKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
                +T    + L P TTY   VRA T KG G
Sbjct: 969 ----TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431

Query: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485

Query: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543

Query: 622 ISVYQVIVEEERARRLRREP 641
             VY    +E++  ++  +P
Sbjct: 544 ELVYWAAEDEDQQHKVTFDP 563



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 79/360 (21%), Positives = 124/360 (34%), Gaps = 49/360 (13%)

Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636

Query: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694

Query: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753

Query: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSR--------YTIKNLLPYRNVHVRLVLTNPEGR 471
                   G      I + V   +   R         TI  L P     V +     +G 
Sbjct: 754 --------GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805

Query: 472 KEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSD 531
               +    T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + 
Sbjct: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEAR 864

Query: 532 PAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
           P         TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 865 P--------NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 11/151 (7%)

Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKE-GKEVTFQTDEDVPSGIAAESLTFTPLEDMIF 504
           S YT+++L P      +L   +  G       +  +T +  PS    + +  +     + 
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624

Query: 505 LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL-RNETYHVFSNLHPGT 561
           + W  P     NG+ITQY ++Y++++  D        R  +  + R  +      L   T
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRG------RHVVDGISREHSSWDLVGLEKWT 678

Query: 562 TYLFSVRARTGKGFG-QAALTEITTNISAPS 591
            Y   VRA T  G G +++   + T+   PS
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPS 709


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  458 bits (1178), Expect = e-128
 Identities = 342/1084 (31%), Positives = 513/1084 (47%), Gaps = 129/1084 (11%)

Query: 383  PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
            P   P+ L    +      L W+P  L     R  +YTV           ++Q   + + 
Sbjct: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 959

Query: 441  TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500
            T+   +R+T+  L P     +++     +G              V    A        ++
Sbjct: 960  TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016

Query: 501  DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560
              + L WE P      +  ++I Y        +V V G   ++ KL        ++L P 
Sbjct: 1017 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1061

Query: 561  TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619
            T Y F +  R     G   L  I T   AP    +  +P+     +    + +   Q   
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1118

Query: 620  APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663
                 Y V+V  +R       P      P  L  +  L                A  L  
Sbjct: 1119 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1176

Query: 664  YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723
            Y  A+L    LPE   FT+GD + YRGF+N PL P  +Y  +  A+     + +    R 
Sbjct: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1228

Query: 724  ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV 783
            A      E    +  +Q+ EE  + L +    LAV++++L  I +++             
Sbjct: 1229 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1274

Query: 784  NYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGS 843
             +++++TH  S+ D           ++ +GL                       SLL  S
Sbjct: 1275 -FKRKRTHSPSSKD-----------EQSIGLK---------------------DSLLAHS 1301

Query: 844  PRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDA 897
               P   +   Y T  +  HP + + DL  +I ++K  +G  F QEYES   G    W+ 
Sbjct: 1302 SD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1360

Query: 898  TKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIAT 957
            +  +     +R   + AYD  RV L  + G P +DYINANYID      GY + N +IAT
Sbjct: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID------GYRKQNAYIAT 1414

Query: 958  QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTE 1016
            QGP PE + DFWRMVW++  +++VM+T+L E  RVKC +YWP   ++T G I++ L+ T 
Sbjct: 1415 QGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTV 1474

Query: 1017 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1076
             LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA  P DAGP
Sbjct: 1475 ELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1534

Query: 1077 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1136
            +V+HCSAG GRTGC+IV+D ML+  + E  VDIY  V  + S+R  M+QTE+QY+FIH+A
Sbjct: 1535 MVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEA 1594

Query: 1137 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1196
            +LEA  CG T +P     A  +++ ++ P  + + +  EF+ L S            A L
Sbjct: 1595 LLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFISANL 1652

Query: 1197 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1253
            P N+ KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  +
Sbjct: 1653 PCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGPLAES 1710

Query: 1254 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1313
            T DFWR+++++  T IVML +L +      C QYWP     +Y    V+ M+       +
Sbjct: 1711 TEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1769

Query: 1314 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1372
             R F+V +    Q     +R FQF  W   +  P + + F+  + +V K + + G DG  
Sbjct: 1770 LREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
             VHC  G GR+G F   + VLE +R   +VD+F   KTLR  +P MV+T DQY  CY  A
Sbjct: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886

Query: 1433 LEYL 1436
            LEYL
Sbjct: 1887 LEYL 1890



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P  P  L+    T   + L  +S   + P+    
Sbjct: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351

Query: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+YR A   GP+ EV  V+   Y +  L P +EY   VL       G G P   + +RT 
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439
              P   P+ +    + A  + +QWEP          Y V    +YT  S          
Sbjct: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465

Query: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
            T+ G+   T+ +LLP     +R L  T          +  +T + VP+   A+      
Sbjct: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523

Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            +  I L W  P  P   I  YE+ Y + E  D    V             + +   +L 
Sbjct: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573

Query: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616
           P T Y F + AR+  G G    T E  T  S PS      M   +G +   ++ +  PA 
Sbjct: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633

Query: 617 GRGAPISVYQVIVE----EERARRL 637
            R   I+ Y V  E    E+R R +
Sbjct: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 68/242 (28%), Positives = 92/242 (38%), Gaps = 43/242 (17%)

Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
           L P+T Y ++V   T  GDG   +P    I  T  A P R    ++   +      LQW 
Sbjct: 778 LTPETTYSVTVAAYTTKGDGARSKPK---IVTTTGAVPGRPTMMISTTAMNTA--LLQWH 832

Query: 406 P--------LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457
           P        LGY +  C               +   TI +  K +Q    +T+  L    
Sbjct: 833 PPKELPGELLGYRLQYCRA-----------DEARPNTI-DFGKDDQ---HFTVTGLHKGT 877

Query: 458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIF-LKWEEP--QEPN 514
               RL   N  G  E  E   +T ED+PSG   ++L  T L      L W+ P   E N
Sbjct: 878 TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERN 936

Query: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKG 574
           G I  Y + ++ I S     N+            +T    + L P TTY   VRA T KG
Sbjct: 937 GRIISYTVVFRDINSQQELQNIT----------TDTRFTLTGLKPDTTYDIKVRAWTSKG 986

Query: 575 FG 576
            G
Sbjct: 987 SG 988



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 42/352 (11%)

Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314
           LYR    A    GV  F   I       TP APPQ +        T  +  +   +   +
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636

Query: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369
           G I +  + Y    G     H V        ++ L  L+  TEY + V      D G G 
Sbjct: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694

Query: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419
              P++ RT    P   P+ +    + +  + + W+ P+         GY VT       
Sbjct: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753

Query: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTF 479
                   G      I + V   +     TI  L P     V +     +G     +   
Sbjct: 754 --------GEPRGLPIIQDVMLAEA-QETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 804

Query: 480 QTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGP 539
            T      G     ++ T +   + L+W  P+E  G +  Y + Y   + + P       
Sbjct: 805 VTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARP------- 856

Query: 540 RRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
             TI   +++ +   + LH GTTY+F + A+   G G+    EI T    PS
Sbjct: 857 -NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 907



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)

Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504
           +RY+I  L P+     R++  N  GR    E V  +T E  PS               + 
Sbjct: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431

Query: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564
           ++WE P+EPNGL+  Y + Y       P  N      T + L         +L PG TY 
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485

Query: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621
             V A T  G G  + T ++ T    P+   AD  + + ES+  I +  LL P +     
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543

Query: 622 ISVYQVIVEEERARRLRREP 641
             VY    +E++  ++  +P
Sbjct: 544 ELVYWAAEDEDQQHKVTFDP 563


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  456 bits (1172), Expect = e-128
 Identities = 351/1120 (31%), Positives = 521/1120 (46%), Gaps = 140/1120 (12%)

Query: 350  DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
            D  Y + VL  T  GDG       P+  +T+   P + P  L         +TL W P  
Sbjct: 485  DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 540

Query: 409  YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
                            Y L        RE  +T    + Y +++L P      RL   +P
Sbjct: 541  QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 590

Query: 469  EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
            +G      V  Q T + + P     + +    ++  + L WE P   N   T Y+I Y  
Sbjct: 591  QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 645

Query: 527  IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
            +      ++V G  RT  KL        ++L P T Y F +   T +G     L +  T 
Sbjct: 646  L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 688

Query: 587  ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
             +A +  +     +P  +++  I V L   Q    P+  Y +++       LR+  GGQ 
Sbjct: 689  WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 742

Query: 646  CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
              P+    +  L            R L H    E+         S LP    F  GD + 
Sbjct: 743  LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 800

Query: 688  YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
            Y GF N  LEP   Y+++  A    K E        +      ++  P  +    E +  
Sbjct: 801  YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 858

Query: 748  ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
            ++G     LAV+ ++   I +++ K KP +  K +                         
Sbjct: 859  VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 890

Query: 808  EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
                               + R+  +   + L    P+ P   +   + T G L HP + 
Sbjct: 891  -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 931

Query: 866  VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
            +AD+ +H  ++K  +     QEYES   G    W+ +  +     +R   + AYD  RV 
Sbjct: 932  IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 991

Query: 922  LHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIV 981
            L P+ G   +DYINANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IV
Sbjct: 992  LQPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1045

Query: 982  MITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVR 1040
            M+T+L E  R+KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVR
Sbjct: 1046 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVR 1105

Query: 1041 QFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDM 1100
            QF FTAWP+HGVP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+ 
Sbjct: 1106 QFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLER 1165

Query: 1101 AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM 1160
             + E  VD+Y  V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++
Sbjct: 1166 IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKL 1225

Query: 1161 IRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPF 1217
             +++P  + + +  EF+ L              A LP N+ KNR ++++P +    CL  
Sbjct: 1226 AQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQP 1283

Query: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
            +   +G  ++YINA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +
Sbjct: 1284 IRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1341

Query: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQF 1337
                  C QYWP     +Y    V+ M+       + R F+V +    Q     VR FQF
Sbjct: 1342 MGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQF 1398

Query: 1338 LRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMI 1396
              W   +  P S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +
Sbjct: 1399 TDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1457

Query: 1397 RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
            R   +VD+F   K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1458 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 300 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 355

Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 356 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 413

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 414 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473

Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 474 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 526

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 527 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 571

Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
             +L P T Y F + AR+ +G G
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLG 594


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  456 bits (1172), Expect = e-128
 Identities = 351/1120 (31%), Positives = 521/1120 (46%), Gaps = 140/1120 (12%)

Query: 350  DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
            D  Y + VL  T  GDG       P+  +T+   P + P  L         +TL W P  
Sbjct: 481  DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536

Query: 409  YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
                            Y L        RE  +T    + Y +++L P      RL   +P
Sbjct: 537  QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 586

Query: 469  EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
            +G      V  Q T + + P     + +    ++  + L WE P   N   T Y+I Y  
Sbjct: 587  QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 641

Query: 527  IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
            +      ++V G  RT  KL        ++L P T Y F +   T +G     L +  T 
Sbjct: 642  L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 684

Query: 587  ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
             +A +  +     +P  +++  I V L   Q    P+  Y +++       LR+  GGQ 
Sbjct: 685  WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 738

Query: 646  CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
              P+    +  L            R L H    E+         S LP    F  GD + 
Sbjct: 739  LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 796

Query: 688  YRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGL 747
            Y GF N  LEP   Y+++  A    K E        +      ++  P  +    E +  
Sbjct: 797  YGGFDNRGLEPGHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIW 854

Query: 748  ILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 807
            ++G     LAV+ ++   I +++ K KP +  K +                         
Sbjct: 855  VIGPV---LAVVFIICIVIAILLYKNKPDSKRKDS------------------------- 886

Query: 808  EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVR 865
                               + R+  +   + L    P+ P   +   + T G L HP + 
Sbjct: 887  -------------------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIP 927

Query: 866  VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 921
            +AD+ +H  ++K  +     QEYES   G    W+ +  +     +R   + AYD  RV 
Sbjct: 928  IADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 987

Query: 922  LHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIV 981
            L P+ G   +DYINANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IV
Sbjct: 988  LQPIEGIMGSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1041

Query: 982  MITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVR 1040
            M+T+L E  R+KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVR
Sbjct: 1042 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVR 1101

Query: 1041 QFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDM 1100
            QF FTAWP+HGVP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+ 
Sbjct: 1102 QFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLER 1161

Query: 1101 AECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEM 1160
             + E  VD+Y  V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++
Sbjct: 1162 IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKL 1221

Query: 1161 IRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPF 1217
             +++P  + + +  EF+ L              A LP N+ KNR ++++P +    CL  
Sbjct: 1222 AQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQP 1279

Query: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
            +   +G  ++YINA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +
Sbjct: 1280 IRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1337

Query: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQF 1337
                  C QYWP     +Y    V+ M+       + R F+V +    Q     VR FQF
Sbjct: 1338 MGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQF 1394

Query: 1338 LRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMI 1396
              W   +  P S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +
Sbjct: 1395 TDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1453

Query: 1397 RCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
            R   +VD+F   K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1454 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351

Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469

Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567

Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
             +L P T Y F + AR+ +G G
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLG 590


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  454 bits (1167), Expect = e-127
 Identities = 323/988 (32%), Positives = 482/988 (48%), Gaps = 105/988 (10%)

Query: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 1029 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1078

Query: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 1079 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1126

Query: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 1127 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1180

Query: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 1181 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1238

Query: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 1239 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1293

Query: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTH-MMSAVDRSFTDQSTLQEDERLGLSFM 817
            + ++   I +++ K KP +  K +    + +T  +++  D +        E  R+     
Sbjct: 1294 VFIICIVIAILLYKNKPDSKRKDS----EPRTKCLLNNADLAPHHPKDPVEMRRINFQTP 1349

Query: 818  DTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMK 877
            D+                         R P    G  + +   HP + +AD+ +H  ++K
Sbjct: 1350 DS-----------------------GLRSPLREPGFHFESMLSHPPIPIADMAEHTERLK 1386

Query: 878  TAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADY 933
              +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +DY
Sbjct: 1387 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1446

Query: 934  INANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVK 993
            INANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+K
Sbjct: 1447 INANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500

Query: 994  CSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGV 1052
            C +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HGV
Sbjct: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560

Query: 1053 PYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNC 1112
            P + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y  
Sbjct: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620

Query: 1113 VKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQL 1172
            V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + +
Sbjct: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680

Query: 1173 REEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYI 1229
              EF+ L              A LP N+ KNR ++++P +    CL  +   +G  ++YI
Sbjct: 1681 ELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYI 1736

Query: 1230 NAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP 1289
            NA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYWP
Sbjct: 1737 NASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYWP 1795

Query: 1290 EPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDS 1349
                 +Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P S
Sbjct: 1796 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKS 1852

Query: 1350 KKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAA 1408
             + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   
Sbjct: 1853 GEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTV 1912

Query: 1409 KTLRNYKPNMVETMDQYHFCYDVALEYL 1436
            K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1913 KMLRTQRPAMVQTEDEYQFCYQAALEYL 1940



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 309 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 364

Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 365 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 422

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 423 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482

Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 483 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 536 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 580

Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
             +L P T Y F + AR+ +G G
Sbjct: 581 VEDLKPNTEYAFRLAARSPQGLG 603



 Score = 50.8 bits (120), Expect = 9e-06
 Identities = 66/270 (24%), Positives = 102/270 (37%), Gaps = 37/270 (13%)

Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
           +Y +  L P+TEY   +    P   G G   P +  RT  ++P   P+ +    +++  +
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635

Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLP----- 455
            + W P             S+ Y   LGS   +      K   G+   T + LL      
Sbjct: 636 LVSWRPPPPETHNGALVGYSVRYR-PLGSEDPEP-----KEVNGIPPTTTQILLEALEKW 689

Query: 456 --YRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEE 509
             YR   V      P    E   V  +TDEDVPS     + AE+L  T +   +  +   
Sbjct: 690 TQYRITTVAHTEVGPG--PESSPVVVRTDEDVPSAPPRKVEAEALNATAIR--VLWRSPA 745

Query: 510 PQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------RNETYHVFSNLHP 559
           P   +G I  Y++ Y  +E ++      GP R    +            E   V +NL P
Sbjct: 746 PGRQHGQIRGYQVHYVRMEGAEAR----GPPRIKDVMLADAQWETDDTAEYEMVITNLQP 801

Query: 560 GTTYLFSVRARTGKGFGQAALTEITTNISA 589
            T Y  +V A T KG G  +  ++     A
Sbjct: 802 ETAYSITVAAYTMKGDGARSKPKVVVTKGA 831



 Score = 39.7 bits (91), Expect = 0.021
 Identities = 55/244 (22%), Positives = 80/244 (32%), Gaps = 35/244 (14%)

Query: 346  HLDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQL 400
            +L P+T Y I+V   T  GDG   +P   +        P     + P+G   A  +    
Sbjct: 798  NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 857

Query: 401  TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
            T + + LGY +                    + T    ++      RYT   +       
Sbjct: 858  TAEDQVLGYRLQF---------------GREDSTPLATLEFPPSEDRYTASGVHKGATYV 902

Query: 461  VRLVLTNPEGRKEGKEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQE 512
             RL   +  G  E         ED P G       A  +   T     + L+W    P E
Sbjct: 903  FRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAE 957

Query: 513  PNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTG 572
             NG I +Y ++ +   +  PA     P        N        L P T Y   VRA T 
Sbjct: 958  RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTR 1015

Query: 573  KGFG 576
            +G G
Sbjct: 1016 RGPG 1019



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 592 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 649

Query: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 650 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 702

Query: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPL--GYNVTRCHTYTVSLCY 423
           G G    P++ RT    P   P+ +    + A  + + W     G    +   Y V    
Sbjct: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762

Query: 424 HYTLGSSHNQTIRECVKTE-----QGVSRY--TIKNLLPYRNVHVRLVLTNPEGRKEGKE 476
                +     I++ +  +        + Y   I NL P     + +     +G     +
Sbjct: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822

Query: 477 VTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVN 535
                 +    G    S+  TP E  +  +WE P       +  Y + +   +S+     
Sbjct: 823 PKVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST----- 876

Query: 536 VPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYA 595
              P  T+    +E  +  S +H G TY+F + AR+  G G+    E    +S P     
Sbjct: 877 ---PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPR 929

Query: 596 DMPSPLGESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640
             P  L  + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 980


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  449 bits (1156), Expect = e-126
 Identities = 322/989 (32%), Positives = 478/989 (48%), Gaps = 123/989 (12%)

Query: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 1007 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1056

Query: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 1057 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1104

Query: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 1105 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1158

Query: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 1159 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1216

Query: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 1217 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1271

Query: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMD 818
            + ++   I +++ K KP +  K +                                    
Sbjct: 1272 VFIICIVIAILLYKNKPDSKRKDS------------------------------------ 1295

Query: 819  THGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVRVADLLQHINQM 876
                    + R+  +   + L    P+ P   +   + T G L HP + +AD+ +H  ++
Sbjct: 1296 --------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 1347

Query: 877  KTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNAD 932
            K  +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +D
Sbjct: 1348 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1407

Query: 933  YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV 992
            YINANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+
Sbjct: 1408 YINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI 1461

Query: 993  KCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHG 1051
            KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HG
Sbjct: 1462 KCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHG 1521

Query: 1052 VPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYN 1111
            VP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y 
Sbjct: 1522 VPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYG 1581

Query: 1112 CVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQ 1171
             V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + 
Sbjct: 1582 HVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTG 1641

Query: 1172 LREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNY 1228
            +  EF+ L              A LP N+ KNR ++++P +    CL  +   +G  ++Y
Sbjct: 1642 MELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDY 1697

Query: 1229 INAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYW 1288
            INA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYW
Sbjct: 1698 INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYW 1756

Query: 1289 PEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPD 1348
            P     +Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P 
Sbjct: 1757 PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPK 1813

Query: 1349 SKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFA 1407
            S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F  
Sbjct: 1814 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1873

Query: 1408 AKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
             K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1874 VKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351

Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469

Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567

Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
             +L P T Y F + AR+ +G G
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLG 590



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 77/350 (22%), Positives = 118/350 (33%), Gaps = 46/350 (13%)

Query: 251 LAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRA----GPTYLIIQL 306
           L A+ +  Q     V+    G G  +   ++  +   P APP+ + A         ++  
Sbjct: 670 LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWR 729

Query: 307 NTNSIIGDGPIVRKEIEY-RM----ARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLL 359
           +       G I   ++ Y RM    ARGP    +V     Q   + +L P+T Y I+V  
Sbjct: 730 SPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAA 789

Query: 360 -TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
            T  GDG   +P   +        P     + P+G   A  +    T + + LGY +   
Sbjct: 790 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF- 848

Query: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
                            + T    ++      RYT   +        RL   +  G  E 
Sbjct: 849 --------------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894

Query: 475 KEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQEPNGLITQYEISYQS 526
                   ED P G       A  +   T     + L+W    P E NG I +Y ++ + 
Sbjct: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAERNGAIVKYTVAVRE 949

Query: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
             +  PA     P        N        L P T Y   VRA T +G G
Sbjct: 950 AGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTRRGPG 997



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 85/405 (20%), Positives = 146/405 (36%), Gaps = 51/405 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 579 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 636

Query: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 637 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 689

Query: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY 425
           G G    P++ RT    P   P+ +    + A  + + W        R H        HY
Sbjct: 690 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQHGQIRGYQVHY 747

Query: 426 TLGSSHNQTIRECVKTEQ--GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDE 483
                        +K           I NL P     + +     +G     +      +
Sbjct: 748 VRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK 807

Query: 484 DVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVNVPGPRRT 542
               G    S+  TP E  +  +WE P       +  Y + +   +S+        P  T
Sbjct: 808 GAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST--------PLAT 858

Query: 543 ISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLG 602
           +    +E  +  S +H G TY+F + AR+  G G+    E    +S P       P  L 
Sbjct: 859 LEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILE 914

Query: 603 ESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640
            + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 915 AAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 958


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  448 bits (1152), Expect = e-125
 Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 1030 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1076

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 1077 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1131

Query: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 1132 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1190

Query: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 1191 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1249

Query: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 1250 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1293

Query: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
                                                   D R   +     +    P  P
Sbjct: 1294 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1318

Query: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1378

Query: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 1379 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1432

Query: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1552

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1553 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1612

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1613 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1670

Query: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1671 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1728

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1729 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1787

Query: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1788 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1844

Query: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1904



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355

Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473

Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519

Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568

Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626

Query: 609 TVLLRP 614
            V  +P
Sbjct: 627 LVSWQP 632



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478

Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531

Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561

Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620

Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675

Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)

Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626

Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684

Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
           +G I  Y++ Y  +E+ +P          ++  + E    T H  + S L P T+Y  +V
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 800

Query: 568 RARTGKGFGQAALTEITTNISA 589
            A T KG G  +  ++ +   A
Sbjct: 801 TAYTTKGDGARSKPKLVSTTGA 822



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 347  LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
            L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 790  LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 844

Query: 406  PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
            P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 845  P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 897

Query: 466  TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
             N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 898  RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 957

Query: 524  YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
            Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 958  YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641

Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699

Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757

Query: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
               Q + + V        +         I  L P  +  + +     +G     +    
Sbjct: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817

Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
           +      G     +  T +   + ++W  P +  G +  Y + +   +          P 
Sbjct: 818 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 868

Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
            T+     E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 869 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  448 bits (1152), Expect = e-125
 Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 1017 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1063

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 1064 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1118

Query: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 1119 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1177

Query: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 1178 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1236

Query: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 1237 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1280

Query: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
                                                   D R   +     +    P  P
Sbjct: 1281 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1305

Query: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1365

Query: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 1366 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1419

Query: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1539

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1540 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1599

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1600 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1657

Query: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1658 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1715

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1716 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1774

Query: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1775 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1831

Query: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1891



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 287 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 342

Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 343 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 400

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460

Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 461 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 506

Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 507 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 555

Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 613

Query: 609 TVLLRP 614
            V  +P
Sbjct: 614 LVSWQP 619



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 352 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 412 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 465

Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 518

Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 554



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 453 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 510

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 511 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 548

Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 549 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607

Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 662

Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 663 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 699



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)

Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 613

Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 614 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 671

Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 672 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 727

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
           +G I  Y++ Y  +E+ +P          ++  + E    T H  + S L P T+Y  +V
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787

Query: 568 RARTGKGFGQAALTEITTNISA 589
            A T KG G  +  ++ +   A
Sbjct: 788 TAYTTKGDGARSKPKLVSTTGA 809



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 777 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 831

Query: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 832 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 884

Query: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 885 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 944

Query: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 945 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 570 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628

Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 686

Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 744

Query: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
               Q + + V        +         I  L P  +  + +     +G     +    
Sbjct: 745 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 804

Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
           +      G     +  T +   + ++W  P +  G +  Y + +   +          P 
Sbjct: 805 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 855

Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
            T+     E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 856 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  448 bits (1152), Expect = e-125
 Identities = 313/960 (32%), Positives = 463/960 (48%), Gaps = 107/960 (11%)

Query: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
            ++  + L WE P+  N  +  ++I Y   +       V G           T  +  NL 
Sbjct: 1021 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1067

Query: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
            P  +Y F +   T +G     L    T  +AP       P+ +G++  +  ITV L P  
Sbjct: 1068 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1122

Query: 617  GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
                 I  Y +I+   ++ R + ++      +     L  E +  R  + Y G E+    
Sbjct: 1123 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1181

Query: 674  LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
               A        FT+GD++ Y GF N  L+  + Y ++F  A     E+++         
Sbjct: 1182 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1240

Query: 728  ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNYRQ 787
                   P  ++   EE GLI  +    LAV+ ++   I +++ K K             
Sbjct: 1241 VVSMDLDPQPITD--EEEGLIW-VVGPVLAVVFIICIVIAILLYKRK------------- 1284

Query: 788  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRP 847
                                                   D R   +     +    P  P
Sbjct: 1285 -----------------------------------RAESDSRKSSIPNNKEIPSHHPTDP 1309

Query: 848  CGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKK 901
               +   + T  +  HP + + +L  HI ++K  +   F QEYES   G    W+ +  +
Sbjct: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 1369

Query: 902  DKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 961
                 +R   + AYD  RV L  + G P +DY+NANYID      GY + N +IATQG  
Sbjct: 1370 VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID------GYRKQNAYIATQGSL 1423

Query: 962  PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAE 1020
            PE   DFWRM+W++  +++VM+TKL E  RVKC +YWP   ++T+G +++ L+ T  LA 
Sbjct: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483

Query: 1021 YVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
            Y VRTFAL + G S + EVRQF FTAWP+HGVP H T  LAF+RRVK   PPDAGP+V+H
Sbjct: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVH 1543

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTGC+IV+D ML+  + E  VDIY  V  + ++R  M+QTE+QYIFIHDA+LEA
Sbjct: 1544 CSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEA 1603

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
              CG T +P     A  +++ +I+   N + +  EF+ L S            A LP N+
Sbjct: 1604 VTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANLPCNK 1661

Query: 1201 DKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             KNR ++++P +    CL  +   +G  ++YINA+  D Y +  A+I T  PL  TT DF
Sbjct: 1662 FKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDF 1719

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVF 1317
            WR+++++  T +VML +L +      C QYWP     +Y    V+ M+       + R F
Sbjct: 1720 WRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1778

Query: 1318 RVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHC 1376
            +V +    Q     VR FQF  W   +  P S + F+  + +V K + + G DG   VHC
Sbjct: 1779 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHC 1835

Query: 1377 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436
              G GR+G F   + VLE +R   +VD+F   K LR  +P MV+T DQY F Y  ALEYL
Sbjct: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYL 1895



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
           Y CV+ +  G  +   A++ VK  P P   P +  +  T + +  ++ +     P+    
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355

Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
           I+++       + E+  V+   Y +  L P ++YE  V+     + G G P  P++++T 
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
              P  AP+ +    + +  + +QW    EP G        YT+    H      HN   
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473

Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
            +           TI NL+P +   V+++     G     +    +D  V   +G+  + 
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519

Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
           L F      E  I L W  P+  +  I  YE+ Y+  E         G  + I+ +   T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568

Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
            +    L P + Y F + AR+ +G G A+  EI+  T  S PS    D+ S    S  +I
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626

Query: 609 TVLLRP 614
            V  +P
Sbjct: 627 LVSWQP 632



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)

Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
           E  K   GV+  RY++  L PY +   R+V  N  GR    E V  QT E  PS    + 
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424

Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
                    I ++W+EP+EPNG I  Y + Y    + DP  +V    +    + +     
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478

Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
             NL P  TY   V A T  G G  ++  ++ T    P         PL    E E+  +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531

Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
           +LL     R   I+ Y+++    E    +R+  EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)

Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
           W + +    Q   + +L P   Y + VL  T  GDG           TG PG PL  +  
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523

Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
            AEP                + L W P      R  T     L Y       H +  R  
Sbjct: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561

Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
           +  E G S Y ++ L P    + RL   +P+G      E++ +T +  PS    +    +
Sbjct: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620

Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
           P    I + W+ P  ++ NG+IT+Y I Y +++  D       P   +    + T ++  
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675

Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
            L   T Y  +V A T  G G  +L+  I TN   PS
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 54/256 (21%), Positives = 104/256 (40%), Gaps = 18/256 (7%)

Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
           +Y+L  L P++ Y   +    P   G G     + +RT  ++P   P+ ++     +  +
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626

Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
            + W+P    V + +         YT     +    E +      ++Y ++ L  +    
Sbjct: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684

Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
           + +      G   E   V  +T+EDVPSG    +  E++  T ++    + W  P   + 
Sbjct: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGK 573
           +G I  Y++ Y  +E+ +P      P      L +    + S L P T+Y  +V A T K
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797

Query: 574 GFGQAALTEITTNISA 589
           G G  +  ++ +   A
Sbjct: 798 GDGARSKPKLVSTTGA 813



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)

Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
           L P+T Y ++V   T  GDG   R  P L+S T           L     Q     +QW 
Sbjct: 781 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 835

Query: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
           P         T+     Y    G    + +     +E+    +T  ++    +   RL  
Sbjct: 836 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 888

Query: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
            N  G  E         E+VP+G      +       + L W+ P   E NG+IT+Y + 
Sbjct: 889 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 948

Query: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
           Y+ I       N+P        +  +T    + L P TTY   VRA T KG G
Sbjct: 949 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 994



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 68/343 (19%), Positives = 126/343 (36%), Gaps = 28/343 (8%)

Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
           +R  +++P+G G S  AE+  +   + P APPQ +       T +++      +   +G 
Sbjct: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641

Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
           I    I+Y    G   + H +         Y L  L+  TEY I+V  T   D G G   
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699

Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
             ++ RT    P   P+ +    + +  + + W     N  + H        HY     G
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757

Query: 429 SSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG 488
               Q + + V          I  L P  +  + +     +G     +    +      G
Sbjct: 758 EPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816

Query: 489 IAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRN 548
                +  T +   + ++W  P +  G +  Y + +   +          P  T+     
Sbjct: 817 KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PLTTLEFSEK 867

Query: 549 ETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
           E +   +++H G +Y+F + AR   GFG+  + EI+     P+
Sbjct: 868 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  398 bits (1022), Expect = e-110
 Identities = 214/592 (36%), Positives = 334/592 (56%), Gaps = 23/592 (3%)

Query: 857  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 911
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264

Query: 912  MPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRM 971
            +  YD  RV L P+ G P++DYINA++I+      GY   N FIA QGPK E V DFWRM
Sbjct: 265  ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318

Query: 972  VWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALER 1030
            +W+++ ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++
Sbjct: 319  IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378

Query: 1031 RGYSARHE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1086
             G     +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG G
Sbjct: 379  VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438

Query: 1087 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1146
            RTG ++V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T
Sbjct: 439  RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498

Query: 1147 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1206
             + V+  +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR +
Sbjct: 499  ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556

Query: 1207 DVLPPDRCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1265
             ++P +     +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++ 
Sbjct: 557  QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616

Query: 1266 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRL 1325
              SIVML +L +      C QYWP  G   YG + VE       E    R   V N    
Sbjct: 617  SCSIVMLTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN 675

Query: 1326 QEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGT 1385
            +     +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GT
Sbjct: 676  KSRQ--IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGT 732

Query: 1386 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
            FCA +TVLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 733  FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  398 bits (1022), Expect = e-110
 Identities = 214/592 (36%), Positives = 334/592 (56%), Gaps = 23/592 (3%)

Query: 857  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 911
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 214  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 273

Query: 912  MPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRM 971
            +  YD  RV L P+ G P++DYINA++I+      GY   N FIA QGPK E V DFWRM
Sbjct: 274  ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 327

Query: 972  VWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALER 1030
            +W+++ ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++
Sbjct: 328  IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 387

Query: 1031 RGYSARHE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1086
             G     +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG G
Sbjct: 388  VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 447

Query: 1087 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1146
            RTG ++V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T
Sbjct: 448  RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 507

Query: 1147 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1206
             + V+  +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR +
Sbjct: 508  ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 565

Query: 1207 DVLPPDRCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1265
             ++P +     +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++ 
Sbjct: 566  QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 625

Query: 1266 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRL 1325
              SIVML +L +      C QYWP  G   YG + VE       E    R   V N    
Sbjct: 626  SCSIVMLTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN 684

Query: 1326 QEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGT 1385
            +     +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GT
Sbjct: 685  KSRQ--IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGT 741

Query: 1386 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
            FCA +TVLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 742  FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  398 bits (1022), Expect = e-110
 Identities = 214/592 (36%), Positives = 334/592 (56%), Gaps = 23/592 (3%)

Query: 857  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 911
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264

Query: 912  MPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRM 971
            +  YD  RV L P+ G P++DYINA++I+      GY   N FIA QGPK E V DFWRM
Sbjct: 265  ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318

Query: 972  VWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALER 1030
            +W+++ ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++
Sbjct: 319  IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378

Query: 1031 RGYSARHE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1086
             G     +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG G
Sbjct: 379  VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438

Query: 1087 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1146
            RTG ++V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T
Sbjct: 439  RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498

Query: 1147 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1206
             + V+  +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR +
Sbjct: 499  ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556

Query: 1207 DVLPPDRCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1265
             ++P +     +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++ 
Sbjct: 557  QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616

Query: 1266 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRL 1325
              SIVML +L +      C QYWP  G   YG + VE       E    R   V N    
Sbjct: 617  SCSIVMLTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN 675

Query: 1326 QEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGT 1385
            +     +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GT
Sbjct: 676  KSRQ--IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGT 732

Query: 1386 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437
            FCA +TVLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 733  FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  370 bits (950), Expect = e-102
 Identities = 212/567 (37%), Positives = 313/567 (55%), Gaps = 23/567 (4%)

Query: 884  FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
            F++E+ S   G     ++   K++  + +R   +   D  RV L  + G P +DYINA+Y
Sbjct: 135  FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194

Query: 939  IDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW 998
            ID      GY   N FIA QGPK E V DFWRMVW++  ++IVM+T L E    KC +YW
Sbjct: 195  ID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 248

Query: 999  PEDSD-TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPY 1054
            P+    TYG+I++ +     L +Y +R F ++ +   G  A   V Q HFT+WP+ GVP+
Sbjct: 249  PDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPF 308

Query: 1055 HATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVK 1114
               G+L F+++VK   P  AGPIV+HCSAG GRTG +IV+D M+ M   E  VD++  V 
Sbjct: 309  TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 368

Query: 1115 TLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLRE 1174
             + ++R  M+QT+ QY FI+ A+LE  L G+T + VS  +   + M       +   L E
Sbjct: 369  RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 428

Query: 1175 EFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAAL 1233
            EF+ L +V   +  E      LP N  K R + ++P D     L    G +  +YINA+ 
Sbjct: 429  EFRKLTNVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 486

Query: 1234 TDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGR 1293
             D Y +   FI T  PL  T  DFWR+++++   +IVML ++ Q      C QYWP  G 
Sbjct: 487  IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGS 545

Query: 1294 QQYGLMEVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSK 1350
              +G + +E  + T  E +  R F V   Q  +R +E   +VR F F  W      P   
Sbjct: 546  VTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEG 604

Query: 1351 KAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1410
            K  + L+A V K Q ++G+    VHC  G GR+GTF A + +LE ++   L+DVF A K+
Sbjct: 605  KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKS 664

Query: 1411 LRNYKPNMVETMDQYHFCYDVALEYLE 1437
            LR  +P+MV+T++QY FCY V  ++++
Sbjct: 665  LRLQRPHMVQTLEQYEFCYKVVQDFID 691



 Score =  131 bits (329), Expect = 5e-30
 Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)

Query: 1158 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1217
            +E IRI    +  Q REEF +L S       E   +A    NR+KNR  ++LP D     
Sbjct: 121  EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 177

Query: 1218 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
            L   DG   ++YINA+  D Y     FI    P Q T  DFWR+V++    +IVML  L 
Sbjct: 178  LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 237

Query: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
            +      C QYWP+ G   YG + V         D   R F +Q   +L +G    R   
Sbjct: 238  ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 294

Query: 1337 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1391
             L ++++ D     TP     FL  +  ++   A    G  +VHC  G GR+GTF     
Sbjct: 295  QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 350

Query: 1392 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1435
            ++ M+     VDVF     +RN +P MV+T  QY F Y   LEY
Sbjct: 351  MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  370 bits (950), Expect = e-102
 Identities = 212/567 (37%), Positives = 313/567 (55%), Gaps = 23/567 (4%)

Query: 884  FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
            F++E+ S   G     ++   K++  + +R   +   D  RV L  + G P +DYINA+Y
Sbjct: 77   FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136

Query: 939  IDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW 998
            ID      GY   N FIA QGPK E V DFWRMVW++  ++IVM+T L E    KC +YW
Sbjct: 137  ID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 190

Query: 999  PEDSD-TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPY 1054
            P+    TYG+I++ +     L +Y +R F ++ +   G  A   V Q HFT+WP+ GVP+
Sbjct: 191  PDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPF 250

Query: 1055 HATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVK 1114
               G+L F+++VK   P  AGPIV+HCSAG GRTG +IV+D M+ M   E  VD++  V 
Sbjct: 251  TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310

Query: 1115 TLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLRE 1174
             + ++R  M+QT+ QY FI+ A+LE  L G+T + VS  +   + M       +   L E
Sbjct: 311  RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370

Query: 1175 EFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAAL 1233
            EF+ L +V   +  E      LP N  K R + ++P D     L    G +  +YINA+ 
Sbjct: 371  EFRKLTNVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428

Query: 1234 TDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGR 1293
             D Y +   FI T  PL  T  DFWR+++++   +IVML ++ Q      C QYWP  G 
Sbjct: 429  IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGS 487

Query: 1294 QQYGLMEVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSK 1350
              +G + +E  + T  E +  R F V   Q  +R +E   +VR F F  W      P   
Sbjct: 488  VTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEG 546

Query: 1351 KAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1410
            K  + L+A V K Q ++G+    VHC  G GR+GTF A + +LE ++   L+DVF A K+
Sbjct: 547  KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKS 606

Query: 1411 LRNYKPNMVETMDQYHFCYDVALEYLE 1437
            LR  +P+MV+T++QY FCY V  ++++
Sbjct: 607  LRLQRPHMVQTLEQYEFCYKVVQDFID 633



 Score =  131 bits (329), Expect = 5e-30
 Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)

Query: 1158 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1217
            +E IRI    +  Q REEF +L S       E   +A    NR+KNR  ++LP D     
Sbjct: 63   EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 119

Query: 1218 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
            L   DG   ++YINA+  D Y     FI    P Q T  DFWR+V++    +IVML  L 
Sbjct: 120  LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 179

Query: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
            +      C QYWP+ G   YG + V         D   R F +Q   +L +G    R   
Sbjct: 180  ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 236

Query: 1337 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1391
             L ++++ D     TP     FL  +  ++   A    G  +VHC  G GR+GTF     
Sbjct: 237  QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 292

Query: 1392 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1435
            ++ M+     VDVF     +RN +P MV+T  QY F Y   LEY
Sbjct: 293  MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  339 bits (870), Expect = 1e-92
 Identities = 211/603 (34%), Positives = 315/603 (52%), Gaps = 52/603 (8%)

Query: 863  AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW--------------DATKKKDKVKGSR 908
            A+ +    +H+  +  + G  F +E+E+  E +              D++   D    +R
Sbjct: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755

Query: 909  QEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDIRINREGYHRSNHFIATQGPKPEMVY 966
               + AYD  RVKL  +        DYINANY+D      GY+R   +IA QGP      
Sbjct: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVD------GYNRPKAYIAAQGPLKSTAE 1809

Query: 967  DFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRT 1025
            DFWRM+W+ +   IVMIT LVE GR KC +YWP D S+ YG+  +     + LA Y VR 
Sbjct: 1810 DFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRN 1869

Query: 1026 FALE--------RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPI 1077
            F L         ++G  +   V Q+H+T WP+ GVP ++  +L F+R+   +     GP+
Sbjct: 1870 FTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPV 1929

Query: 1078 VIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
            V+HCSAG GRTG YIVLD ML   + EG V+I+  +K + S+R  ++QTEEQY+FIHD +
Sbjct: 1930 VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTL 1989

Query: 1138 LEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLP 1197
            +EA L  ET +  S   A Y   + I   +  ++L ++FQ L+     +   + S AL  
Sbjct: 1990 VEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQSN--IQQSDYSAALKQ 2046

Query: 1198 RNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDF 1257
             NR+KNR+  ++P +R    + S  G+  +YINA+    Y +S  FI+T HPL  T  DF
Sbjct: 2047 CNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDF 2106

Query: 1258 WRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ------QYGLMEVEFMSGTADED 1311
            WR+++D+    +VM+   +  N A     YWP           +  LM  E    + +E 
Sbjct: 2107 WRMIWDHNAQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEK 2164

Query: 1312 LVARVFRVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1370
            L+ + F ++     Q+ ++L VRHFQ  +W      PDS  +    L  V K +A + DG
Sbjct: 2165 LIIQDFILE---ATQDDYVLEVRHFQCPKW----PNPDSPISKTFELISVIKEEAANRDG 2217

Query: 1371 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1430
              IVH  +GG  +GTFCA  T++  +   N VDV+  AK +   +P +   ++QY F Y 
Sbjct: 2218 PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYK 2277

Query: 1431 VAL 1433
            V L
Sbjct: 2278 VIL 2280



 Score =  115 bits (288), Expect = 3e-25
 Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 24/291 (8%)

Query: 1169 SSQLREEFQTLNSVTPPLDVEECSIAL--------LPRNRDKNRSMDVLPPDRC---LPF 1217
            SS   EEF+TL       +V+ C++ L         P N+ KNR ++++  D     L  
Sbjct: 1714 SSGFTEEFETLKEFYQ--EVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQ 1771

Query: 1218 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1277
            L   DG   +YINA   D Y R  A+I    PL+ST  DFWR+++++    IVM+  L +
Sbjct: 1772 LAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE 1831

Query: 1278 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHL------- 1330
                  C QYWP  G ++YG   V   S         R F ++N +++++G         
Sbjct: 1832 KGRR-KCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRN-TKIKKGSQKGRPSGR 1889

Query: 1331 LVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACA 1390
            +V  + + +W      P+     L  + +   +      G  +VHC  G GR+GT+    
Sbjct: 1890 VVTQYHYTQWPDM-GVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947

Query: 1391 TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLES 1441
            ++L+ I+    V++F   K +R+ +  +V+T +QY F +D  +E +   E+
Sbjct: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET 1998


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  333 bits (854), Expect = 7e-91
 Identities = 213/609 (34%), Positives = 322/609 (52%), Gaps = 49/609 (8%)

Query: 863  AVRVADLLQHINQMKTAEGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPA 914
            A+ V   ++HI ++ +   +GF +++E               +   ++K K +R   + A
Sbjct: 827  AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHK-NRYINILA 885

Query: 915  YDRHRVKLHPMLG--DPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMV 972
            YD  RVKL P+ G    ++DYINANY+D      GY+++  +IATQGP      DFWRM+
Sbjct: 886  YDHSRVKLRPLPGKDSKHSDYINANYVD------GYNKAKAYIATQGPLKSTFEDFWRMI 939

Query: 973  WQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALER- 1030
            W+++   IVMIT LVE GR KC +YWP E+S+ YG+I + L  T+  A Y VR F++   
Sbjct: 940  WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNT 999

Query: 1031 ----------RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIH 1080
                      +G      V Q+H+T WP+ GVP +A  +L F+RR  A+  P+ GP+++H
Sbjct: 1000 KVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVH 1059

Query: 1081 CSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEA 1140
            CSAG GRTG YIV+D ML   + +  V++   +K + ++R  ++QTEEQYIFIHDA+LEA
Sbjct: 1060 CSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA 1119

Query: 1141 CLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR 1200
             L  ET +  ++   +Y   I I      ++L ++F+ +          EC  A    N+
Sbjct: 1120 ILGKETEVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCN--AKYVECFSAQKECNK 1176

Query: 1201 DKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWR 1259
            +KNR+  V+P +R    L    G    +YINA+    Y RS  FI+T HPL  TT DFWR
Sbjct: 1177 EKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWR 1236

Query: 1260 LVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ------YGLMEVEFMSGTADEDLV 1313
            +++D+    IVML   NQS  A     YWP              L+  + +  + +E ++
Sbjct: 1237 MIWDHNAQIIVMLPD-NQS-LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQII 1294

Query: 1314 ARVFRVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
               F ++     Q+ ++L VRHFQ  +W      PD+  +    L  V K +A + DG T
Sbjct: 1295 IHDFILE---ATQDDYVLEVRHFQCPKW----PNPDAPISSTFELINVIKEEALTRDGPT 1347

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
            IVH   G   +G  CA  T+ + +   N VDVF  AK +   +P +   ++QY F Y   
Sbjct: 1348 IVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407

Query: 1433 LEYLEGLES 1441
            L  +   E+
Sbjct: 1408 LSLVSTKEN 1416


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  310 bits (795), Expect = 5e-84
 Identities = 208/605 (34%), Positives = 302/605 (49%), Gaps = 55/605 (9%)

Query: 867  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 643

Query: 920  VKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSS 979
            V+L  + GD  ++YINA+YID      G+     +IA QGP+ E V DFWRM+W++  + 
Sbjct: 644  VELSEINGDAGSNYINASYID------GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697

Query: 980  IVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
            IVM+T+  E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A 
Sbjct: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT 757

Query: 1037 -HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLD 1095
              EV    FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D
Sbjct: 758  GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID 817

Query: 1096 VMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA 1155
             ML+  E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE   
Sbjct: 818  AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP 877

Query: 1156 TYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RC 1214
                M + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   
Sbjct: 878  YLHNMKKRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNR 934

Query: 1215 LPFL--------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTP 1255
            +P                 S+D DS++     YINA+   SY +    I    PL+ T  
Sbjct: 935  VPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG 994

Query: 1256 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1315
            DFW++++      IVML +L   +    C QYW E G+Q YG +EV+            R
Sbjct: 995  DFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLR 1052

Query: 1316 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-- 1371
            VF +++  R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G   
Sbjct: 1053 VFELRHSKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1109

Query: 1372 -----TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH 1426
                  ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY 
Sbjct: 1110 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1169

Query: 1427 FCYDV 1431
            F YDV
Sbjct: 1170 FLYDV 1174



 Score =  130 bits (328), Expect = 7e-30
 Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 36/279 (12%)

Query: 888  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 904  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 962

Query: 933  ----YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 988
                YINA++I        Y +    IA QGP  E + DFW+M++Q     IVM+T+L  
Sbjct: 963  EPSKYINASFI------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016

Query: 989  VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1048
              +  C++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W 
Sbjct: 1017 GDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWS 1076

Query: 1049 EHGVPYHATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVML 1098
               +P     L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L
Sbjct: 1077 VEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLL 1136

Query: 1099 DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
            + AE E VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1137 ESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175



 Score =  114 bits (285), Expect = 7e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 1076 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1135
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 515  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 572

Query: 1136 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1195
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 573  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 623

Query: 1196 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1254
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 624  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 683

Query: 1255 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1312
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 684  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 742

Query: 1313 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 743  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 799

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1433 LEY 1435
            +EY
Sbjct: 860  VEY 862



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 288 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 345

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 346 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 399

Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 400 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 457

Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
            + R  P   Y   +E E    L R    ++C
Sbjct: 458 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 487



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 355 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 402

Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 403 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 461

Query: 514 NGLITQYEISYQS 526
           NG   +Y +  ++
Sbjct: 462 NGPHERYHLEVEA 474


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  310 bits (795), Expect = 5e-84
 Identities = 208/605 (34%), Positives = 302/605 (49%), Gaps = 55/605 (9%)

Query: 867  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 633  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 691

Query: 920  VKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSS 979
            V+L  + GD  ++YINA+YID      G+     +IA QGP+ E V DFWRM+W++  + 
Sbjct: 692  VELSEINGDAGSNYINASYID------GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 745

Query: 980  IVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
            IVM+T+  E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A 
Sbjct: 746  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT 805

Query: 1037 -HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLD 1095
              EV    FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D
Sbjct: 806  GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID 865

Query: 1096 VMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA 1155
             ML+  E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE   
Sbjct: 866  AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP 925

Query: 1156 TYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RC 1214
                M + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   
Sbjct: 926  YLHNMKKRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNR 982

Query: 1215 LPFL--------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTP 1255
            +P                 S+D DS++     YINA+   SY +    I    PL+ T  
Sbjct: 983  VPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG 1042

Query: 1256 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1315
            DFW++++      IVML +L   +    C QYW E G+Q YG +EV+            R
Sbjct: 1043 DFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLR 1100

Query: 1316 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-- 1371
            VF +++  R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G   
Sbjct: 1101 VFELRHSKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1157

Query: 1372 -----TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH 1426
                  ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY 
Sbjct: 1158 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1217

Query: 1427 FCYDV 1431
            F YDV
Sbjct: 1218 FLYDV 1222



 Score =  130 bits (328), Expect = 7e-30
 Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 36/279 (12%)

Query: 888  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 952  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 1010

Query: 933  ----YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 988
                YINA++I        Y +    IA QGP  E + DFW+M++Q     IVM+T+L  
Sbjct: 1011 EPSKYINASFI------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1064

Query: 989  VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1048
              +  C++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W 
Sbjct: 1065 GDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWS 1124

Query: 1049 EHGVPYHATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVML 1098
               +P     L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L
Sbjct: 1125 VEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLL 1184

Query: 1099 DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
            + AE E VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1185 ESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1223



 Score =  114 bits (285), Expect = 7e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 1076 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1135
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 563  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 620

Query: 1136 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1195
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 621  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 671

Query: 1196 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1254
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 672  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 731

Query: 1255 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1312
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 732  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 790

Query: 1313 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 791  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 847

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1433 LEY 1435
            +EY
Sbjct: 908  VEY 910



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 336 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 393

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 394 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 447

Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 448 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 505

Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
            + R  P   Y   +E E    L R    ++C
Sbjct: 506 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 535



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 403 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 450

Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 451 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 509

Query: 514 NGLITQYEISYQS 526
           NG   +Y +  ++
Sbjct: 510 NGPHERYHLEVEA 522


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  310 bits (795), Expect = 5e-84
 Identities = 208/605 (34%), Positives = 302/605 (49%), Gaps = 55/605 (9%)

Query: 867  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 472  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 530

Query: 920  VKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSS 979
            V+L  + GD  ++YINA+YID      G+     +IA QGP+ E V DFWRM+W++  + 
Sbjct: 531  VELSEINGDAGSNYINASYID------GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584

Query: 980  IVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036
            IVM+T+  E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A 
Sbjct: 585  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT 644

Query: 1037 -HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLD 1095
              EV    FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D
Sbjct: 645  GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID 704

Query: 1096 VMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA 1155
             ML+  E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE   
Sbjct: 705  AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP 764

Query: 1156 TYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RC 1214
                M + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   
Sbjct: 765  YLHNMKKRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNR 821

Query: 1215 LPFL--------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTP 1255
            +P                 S+D DS++     YINA+   SY +    I    PL+ T  
Sbjct: 822  VPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG 881

Query: 1256 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1315
            DFW++++      IVML +L   +    C QYW E G+Q YG +EV+            R
Sbjct: 882  DFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLR 939

Query: 1316 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-- 1371
            VF +++  R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G   
Sbjct: 940  VFELRHSKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 996

Query: 1372 -----TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH 1426
                  ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY 
Sbjct: 997  HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1056

Query: 1427 FCYDV 1431
            F YDV
Sbjct: 1057 FLYDV 1061



 Score =  130 bits (328), Expect = 7e-30
 Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 36/279 (12%)

Query: 888  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 791  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 849

Query: 933  ----YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 988
                YINA++I        Y +    IA QGP  E + DFW+M++Q     IVM+T+L  
Sbjct: 850  EPSKYINASFI------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903

Query: 989  VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1048
              +  C++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W 
Sbjct: 904  GDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWS 963

Query: 1049 EHGVPYHATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVML 1098
               +P     L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L
Sbjct: 964  VEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLL 1023

Query: 1099 DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137
            + AE E VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1024 ESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062



 Score =  114 bits (285), Expect = 7e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 1076 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1135
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 402  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 459

Query: 1136 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1195
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 460  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 510

Query: 1196 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1254
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 511  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 570

Query: 1255 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1312
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 571  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 629

Query: 1313 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 630  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 686

Query: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1433 LEY 1435
            +EY
Sbjct: 747  VEY 749



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 175 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 232

Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 233 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 286

Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 287 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 344

Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
            + R  P   Y   +E E    L R    ++C
Sbjct: 345 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 374



 Score = 32.3 bits (72), Expect = 3.4
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 242 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 289

Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 290 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 348

Query: 514 NGLITQYEISYQS 526
           NG   +Y +  ++
Sbjct: 349 NGPHERYHLEVEA 361


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,004,877
Number of Sequences: 37866
Number of extensions: 2841748
Number of successful extensions: 8627
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 6845
Number of HSP's gapped (non-prelim): 941
length of query: 1442
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1327
effective length of database: 13,892,928
effective search space: 18435915456
effective search space used: 18435915456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.