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Search of human proteins with 166999223
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
(906 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 1839 0.0
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 1798 0.0
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 1283 0.0
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 1283 0.0
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 687 0.0
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 668 0.0
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 656 0.0
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 642 0.0
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 642 0.0
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 642 0.0
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 642 0.0
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 632 0.0
gi|37577159 calcium-sensing receptor [Homo sapiens] 374 e-103
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 255 1e-67
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 254 2e-67
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 218 2e-56
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 194 2e-49
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 194 4e-49
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 155 2e-37
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 112 2e-24
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 56 2e-07
gi|93204867 G protein-coupled receptor 158 [Homo sapiens] 56 2e-07
gi|7706451 G protein-coupled receptor, family C, group 5, member... 53 1e-06
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 49 2e-05
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 49 2e-05
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 49 2e-05
gi|93352554 GPR158-like 1 [Homo sapiens] 47 6e-05
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 45 3e-04
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 45 3e-04
gi|4505441 natriuretic peptide receptor C/guanylate cyclase C (a... 44 9e-04
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 1839 bits (4764), Expect = 0.0
Identities = 906/906 (100%), Positives = 906/906 (100%)
Query: 1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE 60
MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
Sbjct: 1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE 60
Query: 61 KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI 120
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
Sbjct: 61 KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI 120
Query: 121 EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI 180
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
Sbjct: 121 EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI 180
Query: 181 PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG 240
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
Sbjct: 181 PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG 240
Query: 241 MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 300
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
Sbjct: 241 MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 300
Query: 301 SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
Sbjct: 301 SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360
Query: 361 TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM 420
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
Sbjct: 361 TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM 420
Query: 421 AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD 480
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
Sbjct: 421 AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD 480
Query: 481 IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE 540
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
Sbjct: 481 IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE 540
Query: 541 VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS 600
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
Sbjct: 541 VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS 600
Query: 601 CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ 660
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
Sbjct: 601 CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ 660
Query: 661 RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL 720
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
Sbjct: 661 RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL 720
Query: 721 VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
Sbjct: 721 VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
Query: 781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
Sbjct: 781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
Query: 841 KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAKKRQPEFSPTSQCP 900
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAKKRQPEFSPTSQCP
Sbjct: 841 KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAKKRQPEFSPTSQCP 900
Query: 901 SAHVQL 906
SAHVQL
Sbjct: 901 SAHVQL 906
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 1798 bits (4656), Expect = 0.0
Identities = 886/886 (100%), Positives = 886/886 (100%)
Query: 1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE 60
MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE
Sbjct: 1 MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAE 60
Query: 61 KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI 120
KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI
Sbjct: 61 KVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSI 120
Query: 121 EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI 180
EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI
Sbjct: 121 EFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDI 180
Query: 181 PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG 240
PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG
Sbjct: 181 PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESG 240
Query: 241 MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 300
MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
Sbjct: 241 MDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 300
Query: 301 SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360
SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
Sbjct: 301 SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD 360
Query: 361 TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM 420
TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM
Sbjct: 361 TNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAM 420
Query: 421 AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD 480
AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD
Sbjct: 421 AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYD 480
Query: 481 IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE 540
IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE
Sbjct: 481 IMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGE 540
Query: 541 VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS 600
VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
Sbjct: 541 VSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS 600
Query: 601 CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ 660
CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ
Sbjct: 601 CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQ 660
Query: 661 RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL 720
RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL
Sbjct: 661 RLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTL 720
Query: 721 VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN
Sbjct: 721 VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPAN 780
Query: 781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA
Sbjct: 781 FNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
Query: 841 KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNA 886
KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNA
Sbjct: 841 KPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNA 886
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 1283 bits (3320), Expect = 0.0
Identities = 625/853 (73%), Positives = 728/853 (85%), Gaps = 6/853 (0%)
Query: 30 AGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKI 89
A +S +R VA M GD+IIGALFSVHHQP +KV ERKCG +REQYGIQRVEAM HTL++I
Sbjct: 20 AQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERI 79
Query: 90 NADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPP 149
N+DP LLPNITLG EIRDSCWHS+VALEQSIEFIRDSLIS +E++G+ RC+ DG S
Sbjct: 80 NSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLIS-SEEEEGLVRCV-DGSS-SS 136
Query: 150 GRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDT 209
R+KKPI GVIGPGSSSVAIQVQNLLQLF+IPQIAYSATS+DLSDKTL+KYF+RVVPSD
Sbjct: 137 FRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDA 196
Query: 210 LQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKS 269
QARAM+DIVKRYNWTYVSAVHTEGNYGESGM+AFK+++A+EG+CIAHS KIYSNAGE+S
Sbjct: 197 QQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQS 256
Query: 270 FDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEG 329
FD+LL+KL LPKARVV CFCEGMTVRGLL AMRRLG+ GEF L+GSDGWADR +V +G
Sbjct: 257 FDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDG 316
Query: 330 YEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPN 389
Y+ EA GGITIKLQSP+V+ FDDY+LKLR +TN RNPWF EFWQHRFQCRL G EN
Sbjct: 317 YQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSK 376
Query: 390 FKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSK 449
+ + C + +L+ ++VQDSKMGFVINAIY+MA+GL NM +LCPG+ GLCDAMKPIDG K
Sbjct: 377 YNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRK 436
Query: 450 LLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDD 509
LL+ L+K++F GVSG+ + FDE GD+PGRY+IMN + + +DY++VG+W G L +DD
Sbjct: 437 LLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDD 496
Query: 510 YKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGW 569
++ KS ++RSVCSEPC KGQIKVIRKGEVSCCW CT CKENEYV DE+TCKAC LG
Sbjct: 497 DEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGS 556
Query: 570 WPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRE 629
WP DLTGC+ IPV+YL W + E I A+ F+CLG+L TLFVT++F++YRDTPVVKSSSRE
Sbjct: 557 WPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRE 616
Query: 630 LCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGS 689
LCYIILAGI LGY+C F LIAKP CYLQR+ +GLS AM YSALVTKTNRIARILAGS
Sbjct: 617 LCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGS 676
Query: 690 KKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTS 749
KKKICT+KPRFMSA AQ++IA ILI +QL ++V L IMEPP + YPSI+EVYLICNT+
Sbjct: 677 KKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTT 736
Query: 750 NLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN 809
NLGVV PLGYNGLLI+SCT+YAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN
Sbjct: 737 NLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN 796
Query: 810 YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGK---LP 866
YKIIT CF+VSLS TVALGCMF PK+YII+AKPERNVRSAFTTS VVRMHVGDGK
Sbjct: 797 YKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAA 856
Query: 867 CRSNTFLNIFRRK 879
RS++ +N+++R+
Sbjct: 857 SRSSSLVNLWKRR 869
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 1283 bits (3320), Expect = 0.0
Identities = 625/853 (73%), Positives = 728/853 (85%), Gaps = 6/853 (0%)
Query: 30 AGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKI 89
A +S +R VA M GD+IIGALFSVHHQP +KV ERKCG +REQYGIQRVEAM HTL++I
Sbjct: 20 AQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERI 79
Query: 90 NADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPP 149
N+DP LLPNITLG EIRDSCWHS+VALEQSIEFIRDSLIS +E++G+ RC+ DG S
Sbjct: 80 NSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLIS-SEEEEGLVRCV-DGSS-SS 136
Query: 150 GRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDT 209
R+KKPI GVIGPGSSSVAIQVQNLLQLF+IPQIAYSATS+DLSDKTL+KYF+RVVPSD
Sbjct: 137 FRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDA 196
Query: 210 LQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKS 269
QARAM+DIVKRYNWTYVSAVHTEGNYGESGM+AFK+++A+EG+CIAHS KIYSNAGE+S
Sbjct: 197 QQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQS 256
Query: 270 FDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEG 329
FD+LL+KL LPKARVV CFCEGMTVRGLL AMRRLG+ GEF L+GSDGWADR +V +G
Sbjct: 257 FDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDG 316
Query: 330 YEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPN 389
Y+ EA GGITIKLQSP+V+ FDDY+LKLR +TN RNPWF EFWQHRFQCRL G EN
Sbjct: 317 YQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSK 376
Query: 390 FKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSK 449
+ + C + +L+ ++VQDSKMGFVINAIY+MA+GL NM +LCPG+ GLCDAMKPIDG K
Sbjct: 377 YNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRK 436
Query: 450 LLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDD 509
LL+ L+K++F GVSG+ + FDE GD+PGRY+IMN + + +DY++VG+W G L +DD
Sbjct: 437 LLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDD 496
Query: 510 YKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGW 569
++ KS ++RSVCSEPC KGQIKVIRKGEVSCCW CT CKENEYV DE+TCKAC LG
Sbjct: 497 DEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGS 556
Query: 570 WPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRE 629
WP DLTGC+ IPV+YL W + E I A+ F+CLG+L TLFVT++F++YRDTPVVKSSSRE
Sbjct: 557 WPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRE 616
Query: 630 LCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGS 689
LCYIILAGI LGY+C F LIAKP CYLQR+ +GLS AM YSALVTKTNRIARILAGS
Sbjct: 617 LCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGS 676
Query: 690 KKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTS 749
KKKICT+KPRFMSA AQ++IA ILI +QL ++V L IMEPP + YPSI+EVYLICNT+
Sbjct: 677 KKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTT 736
Query: 750 NLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN 809
NLGVV PLGYNGLLI+SCT+YAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN
Sbjct: 737 NLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSN 796
Query: 810 YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGK---LP 866
YKIIT CF+VSLS TVALGCMF PK+YII+AKPERNVRSAFTTS VVRMHVGDGK
Sbjct: 797 YKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAA 856
Query: 867 CRSNTFLNIFRRK 879
RS++ +N+++R+
Sbjct: 857 SRSSSLVNLWKRR 869
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 687 bits (1772), Expect = 0.0
Identities = 381/840 (45%), Positives = 517/840 (61%), Gaps = 41/840 (4%)
Query: 27 VLLAGASSQ---RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMF 83
+LL GA ++ + V ++GD+++G LF VH + P CG + E GIQR+EAM
Sbjct: 11 LLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGG----PAEDCGPVNEHRGIQRLEAML 66
Query: 84 HTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPD 143
LD+IN DP LLP + LG+ I DSC + ALEQ+++F+R SL DG PD
Sbjct: 67 FALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSR---GADGSRHICPD 123
Query: 144 GQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLR 203
G G I GVIG S V+IQV NLL+LF IPQI+Y++TS LSDK+ Y YF R
Sbjct: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
Query: 204 VVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS 263
VP D QA+AM +I++ +NWTYVS V +EG+YGE+G++AF+ A +C+A S+K+
Sbjct: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGR 243
Query: 264 NAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323
+F+ ++R L ++ P ARV V F R LL+A +RL F+ + SDGW
Sbjct: 244 AMSRAAFEGVVRALLQK-PSARVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGAL 300
Query: 324 DEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGH 383
+ V+ G E A G ITI+L S + F YF L N+RNPWF EFW+ RF+C
Sbjct: 301 ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR-- 358
Query: 384 LLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMK 443
+R C + + Q+SK+ FV+NA+YAMAH L NMH ALCP LCDAM+
Sbjct: 359 -------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMR 411
Query: 444 PIDGSKLL-DFLIKSSFIGV-----SGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHV 497
P++G +L DF++ F + EV FD GD GRY+I + RY Y V
Sbjct: 412 PVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKV 471
Query: 498 GTWHEGVLNIDDYKIQM---NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENE 554
G W EG L +D I + + S CSEPCL+ ++K ++ GEV CCW+C C+ E
Sbjct: 472 GYWAEG-LTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEV-CCWLCIPCQPYE 529
Query: 555 YVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIF 614
Y DEFTC C LG+WPNA LTGC +P Y+ W + ++ + +CLG L TLFV +F
Sbjct: 530 YRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVF 589
Query: 615 VLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSA 674
V + TPVVK+S RELCYI+L G+FL Y F IAKP+T C L+RL +G + ++CYSA
Sbjct: 590 VRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSA 649
Query: 675 LVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP-MPI 733
L+TKTNRIARI G+++ ++PRF+S +QV I LIS QL +VV +++E P
Sbjct: 650 LLTKTNRIARIFGGAREG--AQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGK 707
Query: 734 LSYPSIKEVY-LICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792
+ P +EV L CN + ++ L YN LLI CT YAFKTR P NFNEAK+I FTMY
Sbjct: 708 ETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMY 767
Query: 793 TTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNVRS 848
TTCIIWLAF+PI++ S+Y++ TT C +VSLS +V LGC+F PK++II+ +P++NV S
Sbjct: 768 TTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVS 827
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 668 bits (1724), Expect = 0.0
Identities = 367/839 (43%), Positives = 514/839 (61%), Gaps = 34/839 (4%)
Query: 22 SPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEA 81
S G + L + R +++GD+++G LF ++ + + +CG I E GIQR+EA
Sbjct: 16 SKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEA 71
Query: 82 MFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCL 141
M +D+IN D LLP + LG I D+C + ALEQS+EF+R SL + D
Sbjct: 72 MLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV----DEAEYMC 127
Query: 142 PDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYF 201
PDG IAGVIG SSV+IQV NLL+LF IPQI+Y++TS LSDK+ Y YF
Sbjct: 128 PDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYF 187
Query: 202 LRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKI 261
R VP D QA+AM +I++ +NWTYVS V +EG+YGE+G++AF++ A +CIA ++K+
Sbjct: 188 ARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV 247
Query: 262 YSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWA 321
+ KS+D ++R+L ++ P ARVVV F R L++A R F+ + SDGW
Sbjct: 248 GRSNIRKSYDSVIRELLQK-PNARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWG 304
Query: 322 DRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLP 381
++ +I+G E A G IT++L S VR FD YF L N RNPWF +FW+ +FQC L
Sbjct: 305 AQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQ 364
Query: 382 GHLLENPNFKRICTGNESLEE-NYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCD 440
N +R+C + +++ NY Q+SK+ FV+NA+YAMAH L M LCP LCD
Sbjct: 365 N----KRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD 420
Query: 441 AMKPIDGSKLL-DFLIKSSFIGVSGEE------VWFDEKGDAPGRYDIMNLQYTEANRYD 493
AMK +DG KL D+L+K +F V FD GD GRY++ N Q +Y
Sbjct: 421 AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNV-GGKYS 479
Query: 494 YVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKEN 553
Y+ VG W E L++D I +++ V S CS+PC ++K ++ G+V CCWIC C+
Sbjct: 480 YLKVGHWAE-TLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDV-CCWICIPCEPY 537
Query: 554 EYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLI 613
EY+ DEFTC C G WP ADLTGC +P Y+ W + +I + +CLG + T V +
Sbjct: 538 EYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTV 597
Query: 614 FVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYS 673
F+ + +TP+VK+S RELCYI+L G+ L Y F IAKP+ C L+RL +G S A+CYS
Sbjct: 598 FIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYS 657
Query: 674 ALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP--M 731
AL+TKTN IARI G K ++P+F+S +QV I LI VQ+ +V +I+E P
Sbjct: 658 ALLTKTNCIARIFDGVKNG--AQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTR 715
Query: 732 PILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTM 791
+ V L CN + ++ L Y+ +L++ CT YAFKTR P NFNEAK+I FTM
Sbjct: 716 RYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM 775
Query: 792 YTTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
YTTCIIWLAF+PI++ S+Y++ TT C +VSLS V LGC+F PK++II+ +P++NV
Sbjct: 776 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 656 bits (1693), Expect = 0.0
Identities = 359/827 (43%), Positives = 505/827 (61%), Gaps = 37/827 (4%)
Query: 40 RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99
R+DGD+ +G LF VH + K CGE++++ GI R+EAM LD+IN DP LLPNI
Sbjct: 44 RIDGDITLGGLFPVHGRGSEGK----PCGELKKEKGIHRLEAMLFALDRINNDPDLLPNI 99
Query: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGRTK-KPIA 157
TLG+ I D+C + ALEQS+ F++ + EKDG RC G PP TK + +
Sbjct: 100 TLGARILDTCSRDTHALEQSLTFVQALI-----EKDGTEVRC---GSGGPPIITKPERVV 151
Query: 158 GVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLD 217
GVIG SSV+I V N+L+LF IPQI+Y++T+ DLSD + Y +F RVVPSDT QA+AM+D
Sbjct: 152 GVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD 211
Query: 218 IVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEG-LCIAHSDKIYSNAGEKSFDRLLRK 276
IV+ W YVS V +EG+YGESG++AF + + ++G +CIA S KI FD+++R+
Sbjct: 212 IVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRR 271
Query: 277 LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANG 336
L E AR V+ F +R +L A RR G F +GSD W + + E A G
Sbjct: 272 LLET-SNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEG 330
Query: 337 GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTG 396
+TI + VR FD YF LD N RN WF EFW+ F C+L H L+ + + CT
Sbjct: 331 AVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTN 390
Query: 397 NESLEEN--YVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFL 454
E + ++ Y Q+ K+ FVI+A+YAM H L MH LCPG VGLC M P+DG++LL ++
Sbjct: 391 RERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYI 450
Query: 455 IKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQ 513
+F G++G V F+E GDAPGRYDI Q + +Y +G+W + + L I+
Sbjct: 451 RNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSA-EYKVIGSWTDHLHLRIERMHWP 509
Query: 514 MNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNA 573
+ + RS+CS PC G+ K KG + CCW C C +Y D +TCK C P
Sbjct: 510 GSGQQLPRSICSLPCQPGERKKTVKG-MPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTE 568
Query: 574 DLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYI 633
+ TGC PIP+ LEW + +++ + + +GI TLFV + FV Y DTP+VK+S REL Y+
Sbjct: 569 NRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYV 628
Query: 634 ILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKI 693
+LAGIFL Y F +IA+P +C L+R+ +GL ++ Y+AL+TKTNRI RI K+ +
Sbjct: 629 LLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSV 688
Query: 694 CTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLIC 746
PRF+S +Q+ I LIS+QL + +++P ++ + P L C
Sbjct: 689 SA--PRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKC 746
Query: 747 NTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF 806
+ S+L ++ LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCI+WLAF+PI+F
Sbjct: 747 DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFF 806
Query: 807 GSN-------YKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
G++ + T +VSLS +V+LG ++ PK+YII+ PE+NV
Sbjct: 807 GTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNV 853
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 642 bits (1657), Expect = 0.0
Identities = 365/869 (42%), Positives = 519/869 (59%), Gaps = 47/869 (5%)
Query: 4 LLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVA----RMDGDVIIGALFSVHHQPPA 59
L L FP LEV L L A A Q A R++GDV +G LF VH + P+
Sbjct: 11 LTLMKFPCCVLEVLLC-------ALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPS 63
Query: 60 EKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQS 119
VP CG+I+ + GI R+EAM + LD+IN+DP LLPN+TLG+ I D+C + ALEQS
Sbjct: 64 G-VP---CGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQS 119
Query: 120 IEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK-KPIAGVIGPGSSSVAIQVQNLLQLF 178
+ F++ + +KD + +G+ PP K + + GVIG SSV+I V N+L+LF
Sbjct: 120 LTFVQALI-----QKDTSDVRCTNGE--PPVFVKPEKVVGVIGASGSSVSIMVANILRLF 172
Query: 179 DIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGE 238
IPQI+Y++T+ +LSD Y +F RVVP D+ QA+AM+DIVK W YVS + +EG+YGE
Sbjct: 173 QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232
Query: 239 SGMDAFKELAAQEG-LCIAHSDKIYSNAGEKS--FDRLLRKLRERLPKARVVVCFCEGMT 295
G+++F +++ + G LCIA S +I +++ FDR++++L + P +R VV F
Sbjct: 233 KGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDT-PNSRAVVIFANDED 291
Query: 296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL 355
++ +L+A +R VG F +GSD W + + +E A G ITI+ + V FD YF
Sbjct: 292 IKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFT 351
Query: 356 KLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFV 413
L+ N RN WF E+W+ F C+L + + R CTG E + + NY Q+ K+ FV
Sbjct: 352 SRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFV 411
Query: 414 INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKG 473
I+A+YAMAH L +M+ LC + G+C M+ G KLL ++ +F G +G V F++ G
Sbjct: 412 IDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNG 471
Query: 474 DAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQ 532
DAPGRYDI Q T + Y +G W + + LNI+D + + SVC+ PC GQ
Sbjct: 472 DAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQ 531
Query: 533 IKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIE 592
K +KG CCW C C +Y DE TC+ C PN + TGC+ IP+ LEW +
Sbjct: 532 RKKTQKG-TPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPW 590
Query: 593 SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKP 652
++I + + LGI+ T+FV F+ Y DTP+V++S REL Y++L GIFL Y+ F +IAKP
Sbjct: 591 AVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKP 650
Query: 653 TTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASI 712
C +R+ +GL + Y+AL+TKTNRI RI KK + PR +S +Q+ I S
Sbjct: 651 DVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSS 708
Query: 713 LISVQLTLVVTLIIMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIM 765
LISVQL V ++PP I+ Y K + L C+ ++L ++ LGY+ LL++
Sbjct: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMV 768
Query: 766 SCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVS 820
+CT YA KTR VP NFNEAK I FTMYTTCI+WLAF+PI+FG+ I TT +S
Sbjct: 769 TCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTIS 828
Query: 821 --LSVTVALGCMFTPKMYIIIAKPERNVR 847
LS +VALG ++ PK+YIII PE NV+
Sbjct: 829 MNLSASVALGMLYMPKVYIIIFHPELNVQ 857
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 642 bits (1657), Expect = 0.0
Identities = 365/869 (42%), Positives = 519/869 (59%), Gaps = 47/869 (5%)
Query: 4 LLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVA----RMDGDVIIGALFSVHHQPPA 59
L L FP LEV L L A A Q A R++GDV +G LF VH + P+
Sbjct: 11 LTLMKFPCCVLEVLLC-------ALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPS 63
Query: 60 EKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQS 119
VP CG+I+ + GI R+EAM + LD+IN+DP LLPN+TLG+ I D+C + ALEQS
Sbjct: 64 G-VP---CGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQS 119
Query: 120 IEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK-KPIAGVIGPGSSSVAIQVQNLLQLF 178
+ F++ + +KD + +G+ PP K + + GVIG SSV+I V N+L+LF
Sbjct: 120 LTFVQALI-----QKDTSDVRCTNGE--PPVFVKPEKVVGVIGASGSSVSIMVANILRLF 172
Query: 179 DIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGE 238
IPQI+Y++T+ +LSD Y +F RVVP D+ QA+AM+DIVK W YVS + +EG+YGE
Sbjct: 173 QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232
Query: 239 SGMDAFKELAAQEG-LCIAHSDKIYSNAGEKS--FDRLLRKLRERLPKARVVVCFCEGMT 295
G+++F +++ + G LCIA S +I +++ FDR++++L + P +R VV F
Sbjct: 233 KGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDT-PNSRAVVIFANDED 291
Query: 296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL 355
++ +L+A +R VG F +GSD W + + +E A G ITI+ + V FD YF
Sbjct: 292 IKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFT 351
Query: 356 KLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFV 413
L+ N RN WF E+W+ F C+L + + R CTG E + + NY Q+ K+ FV
Sbjct: 352 SRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFV 411
Query: 414 INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKG 473
I+A+YAMAH L +M+ LC + G+C M+ G KLL ++ +F G +G V F++ G
Sbjct: 412 IDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNG 471
Query: 474 DAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQ 532
DAPGRYDI Q T + Y +G W + + LNI+D + + SVC+ PC GQ
Sbjct: 472 DAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQ 531
Query: 533 IKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIE 592
K +KG CCW C C +Y DE TC+ C PN + TGC+ IP+ LEW +
Sbjct: 532 RKKTQKG-TPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPW 590
Query: 593 SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKP 652
++I + + LGI+ T+FV F+ Y DTP+V++S REL Y++L GIFL Y+ F +IAKP
Sbjct: 591 AVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKP 650
Query: 653 TTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASI 712
C +R+ +GL + Y+AL+TKTNRI RI KK + PR +S +Q+ I S
Sbjct: 651 DVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSS 708
Query: 713 LISVQLTLVVTLIIMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIM 765
LISVQL V ++PP I+ Y K + L C+ ++L ++ LGY+ LL++
Sbjct: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMV 768
Query: 766 SCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVS 820
+CT YA KTR VP NFNEAK I FTMYTTCI+WLAF+PI+FG+ I TT +S
Sbjct: 769 TCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTIS 828
Query: 821 --LSVTVALGCMFTPKMYIIIAKPERNVR 847
LS +VALG ++ PK+YIII PE NV+
Sbjct: 829 MNLSASVALGMLYMPKVYIIIFHPELNVQ 857
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 642 bits (1656), Expect = 0.0
Identities = 358/827 (43%), Positives = 503/827 (60%), Gaps = 36/827 (4%)
Query: 40 RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99
R+DGD+I+G LF VH + VP CGE++++ GI R+EAM + +D+IN DP LL NI
Sbjct: 41 RVDGDIILGGLFPVHAKGE-RGVP---CGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96
Query: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKP-IAG 158
TLG I D+C + ALEQS+ F++ + EKD + +G PP TK I+G
Sbjct: 97 TLGVRILDTCSRDTYALEQSLTFVQALI-----EKDASDVKCANGD--PPIFTKPDKISG 149
Query: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218
VIG +SSV+I V N+L+LF IPQI+Y++T+ +LSD T Y +F RVVP D+ QA+AM+DI
Sbjct: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209
Query: 219 VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQ-EGLCIAHSDKIYSNAGEKSFDRLLRKL 277
V W YVS + +EGNYGESG++AF +++ + G+CIA S KI F++++++L
Sbjct: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269
Query: 278 RERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGG 337
E P AR V+ F +R +L A ++L G F IGSD W + + E A G
Sbjct: 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGA 328
Query: 338 ITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGN 397
+TI + + FD YF L N RN WF EFW+ F C+L H N + K+ CTG
Sbjct: 329 VTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKK-CTGL 387
Query: 398 ESL--EENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455
E + + +Y Q+ K+ FVI+A+Y+MA+ L NMH LCPG++GLC M IDG +LL ++
Sbjct: 388 ERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIR 447
Query: 456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQM 514
+F G +G V F+E GDAPGRYDI Q T + +Y +G W + L ++D +
Sbjct: 448 AVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAH 506
Query: 515 NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNAD 574
+ SVCS PC G+ K KG V CCW C C+ Y DE +C+ C L PN +
Sbjct: 507 REHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMN 565
Query: 575 LTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYII 634
TGC+ IP+ LEW + +++ + + LGI+ T FV + FV Y DTP+V++S REL Y++
Sbjct: 566 RTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVL 625
Query: 635 LAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKIC 694
L GIFL Y F +IA P T C +R+ +GL Y+AL+TKTNRI RI KK +
Sbjct: 626 LTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVT 685
Query: 695 TRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLICN 747
P+F+S +Q++I LISVQL V +++PP I+ Y P L C+
Sbjct: 686 A--PKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCD 743
Query: 748 TSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807
S+L ++ LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCIIWLAF+PI+FG
Sbjct: 744 ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803
Query: 808 S-------NYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVR 847
+ + T ++SLS +V+LG ++ PK+YIII PE+NV+
Sbjct: 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 642 bits (1656), Expect = 0.0
Identities = 358/827 (43%), Positives = 503/827 (60%), Gaps = 36/827 (4%)
Query: 40 RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99
R+DGD+I+G LF VH + VP CGE++++ GI R+EAM + +D+IN DP LL NI
Sbjct: 41 RVDGDIILGGLFPVHAKGE-RGVP---CGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96
Query: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKP-IAG 158
TLG I D+C + ALEQS+ F++ + EKD + +G PP TK I+G
Sbjct: 97 TLGVRILDTCSRDTYALEQSLTFVQALI-----EKDASDVKCANGD--PPIFTKPDKISG 149
Query: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218
VIG +SSV+I V N+L+LF IPQI+Y++T+ +LSD T Y +F RVVP D+ QA+AM+DI
Sbjct: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209
Query: 219 VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQ-EGLCIAHSDKIYSNAGEKSFDRLLRKL 277
V W YVS + +EGNYGESG++AF +++ + G+CIA S KI F++++++L
Sbjct: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269
Query: 278 RERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGG 337
E P AR V+ F +R +L A ++L G F IGSD W + + E A G
Sbjct: 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGA 328
Query: 338 ITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGN 397
+TI + + FD YF L N RN WF EFW+ F C+L H N + K+ CTG
Sbjct: 329 VTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKK-CTGL 387
Query: 398 ESL--EENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455
E + + +Y Q+ K+ FVI+A+Y+MA+ L NMH LCPG++GLC M IDG +LL ++
Sbjct: 388 ERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIR 447
Query: 456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQM 514
+F G +G V F+E GDAPGRYDI Q T + +Y +G W + L ++D +
Sbjct: 448 AVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAH 506
Query: 515 NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNAD 574
+ SVCS PC G+ K KG V CCW C C+ Y DE +C+ C L PN +
Sbjct: 507 REHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMN 565
Query: 575 LTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYII 634
TGC+ IP+ LEW + +++ + + LGI+ T FV + FV Y DTP+V++S REL Y++
Sbjct: 566 RTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVL 625
Query: 635 LAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKIC 694
L GIFL Y F +IA P T C +R+ +GL Y+AL+TKTNRI RI KK +
Sbjct: 626 LTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVT 685
Query: 695 TRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLICN 747
P+F+S +Q++I LISVQL V +++PP I+ Y P L C+
Sbjct: 686 A--PKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCD 743
Query: 748 TSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807
S+L ++ LGY+ LL+++CT YA KTR VP FNEAK I FTMYTTCIIWLAF+PI+FG
Sbjct: 744 ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803
Query: 808 S-------NYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVR 847
+ + T ++SLS +V+LG ++ PK+YIII PE+NV+
Sbjct: 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 632 bits (1631), Expect = 0.0
Identities = 361/875 (41%), Positives = 515/875 (58%), Gaps = 40/875 (4%)
Query: 14 LEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQ 73
L V+LLP + + AG + R+ G + +G LF VH A R CG+++++
Sbjct: 11 LLVALLPLA---WLAQAGLARAAGSVRLAGGLTLGGLFPVH----ARGAAGRACGQLKKE 63
Query: 74 YGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDE 133
G+ R+EAM + LD++NADP LLP + LG+ + D+C + ALEQ++ F++ +LI R +
Sbjct: 64 QGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQ-ALIRGRGD 122
Query: 134 KDGINRCLPDGQSLPPGRTKKP--IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSID 191
D + P G +PP R P + V+G +SSV+I V N+L+LF IPQI+Y++T+ +
Sbjct: 123 GDEVGVRCPGG--VPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE 180
Query: 192 LSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQE 251
LSD T Y +F RVVP D+ QA+AM+DIV+ W YVS + +EGNYGESG++AF +++ +
Sbjct: 181 LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA 240
Query: 252 G-LCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVG 310
G +CIA S KI F +++R+L E P AR ++ F +R +L A R+ + G
Sbjct: 241 GGVCIAQSIKIPREPKPGEFSKVIRRLMET-PNARGIIIFANEDDIRRVLEAARQANLTG 299
Query: 311 EFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPE 370
F +GSD W + I E A G ITI + + FD YF+ L+ N RN WF E
Sbjct: 300 HFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAE 359
Query: 371 FWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFVINAIYAMAHGLQNMH 428
FW+ F C+L ++ + R CTG E + + Y Q+ K+ FVI+A+YA+AH L +MH
Sbjct: 360 FWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMH 419
Query: 429 HALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTE 488
ALCPGH GLC AM+P DG LL ++ F G +G V F+E GDAPGRYDI Q T
Sbjct: 420 QALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATN 479
Query: 489 --ANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCW 545
A+ Y VG W E + L+++ + + V S+CS PC G+ K + KG V CCW
Sbjct: 480 GSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKG-VPCCW 538
Query: 546 ICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGIL 605
C AC + DEFTC+AC P + TGC P PV L WS+ + + + LGI+
Sbjct: 539 HCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIV 598
Query: 606 VTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVG 665
T V FV Y +TP+V++S REL Y++L GIFL Y F ++A+P C +RL +G
Sbjct: 599 ATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLG 658
Query: 666 LSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI 725
L + + YSAL+TKTNRI RI K+ + P F+S +Q++I L S+Q+ ++ +
Sbjct: 659 LGTTLSYSALLTKTNRIYRIFEQGKRSV--TPPPFISPTSQLVITFSLTSLQVVGMIAWL 716
Query: 726 IMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVP 778
PP ++ Y + V L C+ S+L ++ LGY+ LL+++CT YA K R VP
Sbjct: 717 GARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVP 776
Query: 779 ANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVSLSV--TVALGCMF 831
FNEAK I FTMYTTCIIWLAFVPI+FG+ I TT VSLS+ +V+LG ++
Sbjct: 777 ETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLY 836
Query: 832 TPKMYIIIAKPERNV----RSAFTTSDVVRMHVGD 862
PK Y+I+ PE+NV RS TS V G+
Sbjct: 837 VPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGE 871
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 374 bits (961), Expect = e-103
Identities = 264/916 (28%), Positives = 441/916 (48%), Gaps = 74/916 (8%)
Query: 39 ARMDGDVIIGALFSVHHQPPAEKVPERKCGE----IREQY-GIQRVEAMFHTLDKINADP 93
A+ GD+I+G LF +H A+ + E IR + G + ++AM +++IN+ P
Sbjct: 26 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSP 85
Query: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
LLPN+TLG I D+C S ALE ++ F+ + I + + N C + +P
Sbjct: 86 ALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN-C---SEHIPS---- 137
Query: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
V+G S V+ V NLL LF IPQ++Y+++S LS+K +K FLR +P+D QA
Sbjct: 138 --TIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQAT 195
Query: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRL 273
AM DI++ + W +V + + +YG G++ F+E A + +CI S+ I + E+ +
Sbjct: 196 AMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHV 255
Query: 274 LRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEV-IEGYEV 332
+ ++ A+V+V F G + L+ + R + G+ L S+ WA + + Y
Sbjct: 256 VEVIQN--STAKVIVVFSSGPDLEPLIKEIVRRNITGKIWL-ASEAWASSSLIAMPQYFH 312
Query: 333 EANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL------------ 380
G I L++ ++ F ++ K+ + N + EFW+ F C L
Sbjct: 313 VVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDT 372
Query: 381 -------PGHLLENPN--FKRICTGNE---SLEENYVQDSKMGFVIN---AIYAMAHGLQ 425
G N + F+ +CTG+E S+E Y+ + + N A+Y++AH LQ
Sbjct: 373 FLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQ 432
Query: 426 NMHHALCPGH----VGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDI 481
+++ L PG G C +K ++ ++L L +F GE+V FDE GD G Y I
Sbjct: 433 DIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSI 491
Query: 482 MNLQYTEAN------RYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSV----CSEPCLKG 531
+N + + Y +V L I++ KI SG R V CS CL G
Sbjct: 492 INWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILW--SGFSREVPFSNCSRDCLAG 549
Query: 532 QIKVIRKGEVSCCWICTACKENEYVQ--DEFTCKACDLGWWPNADLTGCEPIPVRYLEWS 589
K I +GE +CC+ C C + EY D C C +W N + T C + +L W+
Sbjct: 550 TRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWT 609
Query: 590 NIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLI 649
I F+ LGI +T FV +F+ +R+TP+VK+++REL Y++L + + I
Sbjct: 610 EPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFI 669
Query: 650 AKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVII 709
+P +C L++ G+S +C S ++ KTNR+ + RK + Q ++
Sbjct: 670 GEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRK--WWGLNLQFLL 727
Query: 710 ASILISVQLTLVVTLIIMEPPMPILSYPSIKE-VYLICNTSNLGVVAPL-GYNGLLIMSC 767
+ +Q+ + V + PP + E +++ C+ +L + L GY LL C
Sbjct: 728 VFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAIC 787
Query: 768 TYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTV-- 825
++AFK+R +P NFNEAK+I F+M I+W++F+P Y + K ++ +++
Sbjct: 788 FFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFG 847
Query: 826 ALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGN 885
L C+F K+YII+ KP RN S + R + N+ R++ + G
Sbjct: 848 LLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRS---NVSRKRSSSLGG 904
Query: 886 AKKRQPEFSPTSQCPS 901
+ P S +S+ S
Sbjct: 905 STGSTPSSSISSKSNS 920
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 255 bits (651), Expect = 1e-67
Identities = 222/842 (26%), Positives = 384/842 (45%), Gaps = 74/842 (8%)
Query: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
Query: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
Query: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
Query: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
Query: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
Query: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
Query: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPID 446
+ K S Y A+YA+AHGL H L G C + +
Sbjct: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGL----HQLLGCASGACSRGR-VY 417
Query: 447 GSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVG--TWHEGV 504
+LL+ + K F+ + + V F++ D Y+I+ + ++ + +G TW
Sbjct: 418 PWQLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDW-NGPKWTFTVLGSSTWSPVQ 475
Query: 505 LNIDDYKIQMN--KSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYV--QDEF 560
LNI++ KIQ + + V +SVCS CL+G +V+ G CC+ C C ++ D +
Sbjct: 476 LNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVV-TGFHHCCFECVPCGAGTFLNKSDLY 534
Query: 561 TCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDT 620
C+ C W C P V +L S + +A + L +L+ L +F + DT
Sbjct: 535 RCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDT 594
Query: 621 PVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTN 680
PVV+S+ LC+++L + G + +PT +C L++ L L + S L ++
Sbjct: 595 PVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSF 654
Query: 681 RIARILAGSKKKICTRKPRFMSAWAQVIIASILISV----QLTLVVTLIIMEPPMPILSY 736
++ I K T+ P F AW Q A + + + QL + +T +++ P+P Y
Sbjct: 655 QLIIIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREY 709
Query: 737 PSIKEVYLI--CNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTT 794
+ ++ T++LG + YNGLL +S ++ +++P N+NEAK + F++
Sbjct: 710 QRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFN 769
Query: 795 CIIWLAF---VPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFT 851
+ W+AF +Y G Y A S++ G F PK Y+I+ +P+ N F
Sbjct: 770 FVSWIAFFTTASVYDG-KYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQ 828
Query: 852 TS 853
S
Sbjct: 829 AS 830
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 254 bits (650), Expect = 2e-67
Identities = 226/849 (26%), Positives = 380/849 (44%), Gaps = 66/849 (7%)
Query: 39 ARMDGDVIIGALFSVHHQP-PAEKVPERKCGEIREQYGIQ-----RVEAMFHTLDKINAD 92
A G +IIG LF++H + +E P R +I+E G + + AM H+++ IN +
Sbjct: 30 ATSPGHIIIGGLFAIHEKMLSSEDSPRRP--QIQECVGFEISVFLQTLAMIHSIEMIN-N 86
Query: 93 PVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGR 151
LLP + LG EI D+C +VA+ ++ F L ++ + +C D S P
Sbjct: 87 STLLPGVKLGYEIYDTCTEVTVAMAATLRF----LSKFNCSRETVEFKC--DYSSYMPR- 139
Query: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
+ VIG G S + + V +L L +PQ+ Y +T+ LSDK + FLR VPSD Q
Sbjct: 140 ----VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
Query: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFD 271
+AM ++++ W ++ + T+ +YG ++ F A +CIA + + + + + +
Sbjct: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
Query: 272 -RLLRKLRERLPKAR--VVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIE 328
R+ R L++ + +A+ V+V F V L + + + I SD W+ ++
Sbjct: 256 VRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI--NKMWIASDNWSTATKITT 313
Query: 329 GYEVEANGGIT-IKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCR------LP 381
V+ G + + + SF + L L + + E+ H C L
Sbjct: 314 IPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLS 373
Query: 382 GHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDA 441
+ + N+++E N+V + + A + H +Q AL LC A
Sbjct: 374 QCIFNHSQRTLAYKANKAIERNFVMRNDFLWDY-AEPGLIHSIQLAVFALGYAIRDLCQA 432
Query: 442 MKPIDGSKLLDFLIKSSFIGVSGEEVW----FDEKGDAPGRYDIM-------NLQYTEAN 490
+ + + + V+ + W FD GD YD++ ++ T+
Sbjct: 433 RDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMA 492
Query: 491 RYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTAC 550
YD + ++ + K + ++S CS+ C GQ+K + + CC+ C C
Sbjct: 493 EYDLQN----DVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNC 548
Query: 551 KENEYVQ--DEFTCKAC-DLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVT 607
EN Y D C C + W T C V YL W++ +I+ + S LGI+
Sbjct: 549 PENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFV 608
Query: 608 LFVTLIFVLYRDTPVVKSS-SRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGL 666
L V +IF +TPVVKSS +CY+IL FL + I +P +C ++ + G+
Sbjct: 609 LVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGV 668
Query: 667 SSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSA-WAQVIIASILISVQLTLVVTLI 725
S +C S ++TK+ +I +LA S + +F+ + ++I +Q+ + +
Sbjct: 669 SFTLCISCILTKSLKI--LLAFS---FDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWL 723
Query: 726 IMEPPMPILSYPSIKEVYLICNT-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEA 784
I P ++ + + L C S L LGY +L C +AFK + N+NEA
Sbjct: 724 IFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEA 781
Query: 785 KYIAFTMYTTCIIWLAFVPIY---FGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAK 841
K+I F M I W+ F+PIY FG Y + +S L C F PK Y+II K
Sbjct: 782 KFITFGMLIYFIAWITFIPIYATTFG-KYVPAVEIIVILISNYGILYCTFIPKCYVIICK 840
Query: 842 PERNVRSAF 850
E N +SAF
Sbjct: 841 QEINTKSAF 849
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 218 bits (555), Expect = 2e-56
Identities = 215/863 (24%), Positives = 384/863 (44%), Gaps = 113/863 (13%)
Query: 41 MDGDVIIGALFSVHHQPPAE------KVPERKCGEIREQYGIQRVEAMFHTLDKINADPV 94
+ GD ++G LFS+H +VP K E++ G ++AM +++IN D
Sbjct: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKV-IGYNLMQAMRFAVEEINNDSS 87
Query: 95 LLPNITLGSEIRDSCWHSSVALEQSIEFI--RDSLISIRDEKDG-INRCLPDGQSLPPGR 151
LLP + LG EI D C+ S+ ++ + F+ D+L+ I+++ I+R
Sbjct: 88 LLPGVLLGYEIVDVCYISN-NVQPVLYFLAHEDNLLPIQEDYSNYISR------------ 134
Query: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
+ VIGP +S + V N L LF +PQI YSA S +L DK + LR PS
Sbjct: 135 ----VVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHH 190
Query: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS---NAGEK 268
AM+ ++ + W ++ + + YG E A+ +CIA + + + N
Sbjct: 191 IEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMT 250
Query: 269 SFDR-----LLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323
S +R ++ KL++ ARVVV F +T+ + + R G I S+ WA
Sbjct: 251 SEERQRLVTIVDKLQQST--ARVVVVFSPDLTLYHFFNEVLRQNFTGAV-WIASESWAID 307
Query: 324 DEVIEGYEVEANG---GITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL 380
+ E+ G GITI QS + F ++ W P+
Sbjct: 308 PVLHNLTELRHLGTFLGITI--QSVPIPGFSEF-----------REWGPQAGPPPLS--- 351
Query: 381 PGHLLENPNFKRICTG--NESLEENYVQ----DSKMGFVINAIYAMAHGLQNMHHALCPG 434
++ + C N +L N + + + V +A+YA+AH L H+L
Sbjct: 352 --RTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHAL----HSLLGC 405
Query: 435 HVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDY 494
C + + +LL+ + K +F + +++FD +GD +I+ Q+ + ++ +
Sbjct: 406 DKSTC-TKRVVYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQW-DRSQNPF 462
Query: 495 VHVGTWH---EGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACK 551
V +++ + NI D + + S+CS+ C GQ K G CC+ C C
Sbjct: 463 QSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKK-PVGIHVCCFECIDCL 521
Query: 552 ENEYV---QDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTL 608
++ +DE+ C+AC W T C + +LEW +I + LG L TL
Sbjct: 522 PGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTL 581
Query: 609 FVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSS 668
+ +IF + TP+V+S+ +C+++L + + Y+ + P ++C ++ L L
Sbjct: 582 AILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCF 641
Query: 669 AMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQ-----VIIASILISVQLTLVVT 723
+C S + ++ +I K+ +R PR S W + V +A I + + +V+
Sbjct: 642 TICISCIAVRSFQIVCAF-----KMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIG 696
Query: 724 LII--------MEPPMPILSYPSIKEVY---LICNTSNLGVVAPLGYNGLLIMSCTYYAF 772
++ +P P ++ S Y L+ NTS +++ +G++ +A+
Sbjct: 697 MLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFS---------FAY 747
Query: 773 KTRNVPANFNEAKYIAFTM---YTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGC 829
+ +P N+NEAK+I +M +T+ + F+ Y G I+ V + ++LG
Sbjct: 748 MGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLG- 806
Query: 830 MFTPKMYIIIAKPERNVRSAFTT 852
F PK Y+I+ PERN + F +
Sbjct: 807 YFGPKCYMILFYPERNTPAYFNS 829
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 194 bits (494), Expect = 2e-49
Identities = 216/844 (25%), Positives = 356/844 (42%), Gaps = 77/844 (9%)
Query: 40 RMDGDVIIGALFSVHHQPPAE-KVPERKCGEIREQY---GIQRVEAMFHTLDKINADPVL 95
RM GD ++G LF + A + R + ++ G+ AM +++IN L
Sbjct: 30 RMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDL 89
Query: 96 LPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKP 155
LP + LG ++ D+C VA++ S+ F+ + RD N + +
Sbjct: 90 LPGLRLGYDLFDTCSEPVVAMKPSLMFLAKA--GSRDIAAYCNYT----------QYQPR 137
Query: 156 IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAM 215
+ VIGP SS +A+ F +PQ++Y A+ LS + + F R VPSD +Q A
Sbjct: 138 VLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAA 197
Query: 216 LDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLR 275
++++ + W +V+A+ ++ YG G+ F LAA G+CIAH + + D L
Sbjct: 198 AELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRAD---DSRLG 254
Query: 276 KLRERLPKA-----RVVVCFCEGMTVRGLL--SAMRRLGVVGEFSLIGSDGWADRDEVIE 328
K+++ L + +VV+ F L S RL + S+ W D V+
Sbjct: 255 KVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPK---VWVASEAWLTSDLVMG 311
Query: 329 GYEVEANGGITIKLQ-SPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLEN 387
+ G + LQ ++ F Y +K L T +P F R Q + +
Sbjct: 312 LPGMAQMGTVLGFLQRGAQLHEFPQY-VKTHLALAT-DPAFCSALGEREQGLEEDVVGQR 369
Query: 388 -PNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPID 446
P I N S N+ Q V A+Y++A L N G C A P+
Sbjct: 370 CPQCDCITLQNVSAGLNHHQTFS---VYAAVYSVAQALHNTLQCNASG----CPAQDPVK 422
Query: 447 GSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLN 506
+LL+ + +F V G + FD G+ YD+ L + + VG ++ G L
Sbjct: 423 PWQLLENMYNLTF-HVGGLPLRFDSSGNVDMEYDL-KLWVWQGSVPRLHDVGRFN-GSLR 479
Query: 507 IDDYKIQMNKSGVVRSV--CSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQ--DEFTC 562
+ KI+ + S + V CS C +GQ++ + KG SCC+ C C+ Y Q D+ C
Sbjct: 480 TERLKIRWHTSDNQKPVSRCSRQCQEGQVRRV-KGFHSCCYDCVDCEAGSYRQNPDDIAC 538
Query: 563 KACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPV 622
C W T C R+L W ++ + L + + L +FV +RD+P+
Sbjct: 539 TFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPL 598
Query: 623 VKSSSRELCYIILAGIFLGYVCPFTLI--AKPTTTSCYLQRLLVGLSSAMCYSALVTKTN 680
V++S L L + LG VC L+ +P+ C Q+ L L C S L +
Sbjct: 599 VQASGGPLACFGL--VCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQA- 655
Query: 681 RIARILAGSKKKI--------CTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMP 732
A I S+ + C R P AW V++A + V++ L ++ PP
Sbjct: 656 --AEIFVESELPLSWADRLSGCLRGP---WAWLVVLLAML---VEVALCTWYLVAFPPEV 707
Query: 733 ILSYPSIKEVYLICNTSNLGVVAPLGY--NGLLIMSCTYYAFKTRNVPANFNEAKYIAFT 790
+ + + L+ + V L + N L C F R+ P +N A+ + F
Sbjct: 708 VTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFA 767
Query: 791 MYTTCIIWLAFVPIYFGSNYKII----TTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
M I W++FVP+ +N +++ A+ L V L P+ Y+++ +P N
Sbjct: 768 MLAYFITWVSFVPLL--ANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNT 825
Query: 847 RSAF 850
F
Sbjct: 826 PEFF 829
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 194 bits (492), Expect = 4e-49
Identities = 106/209 (50%), Positives = 146/209 (69%), Gaps = 8/209 (3%)
Query: 646 FTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWA 705
F IAKP+T C L+RL +G + ++CYSAL+TKTNRIARI G+++ ++PRF+S +
Sbjct: 3 FIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREG--AQRPRFISPAS 60
Query: 706 QVIIASILISVQLTLVVTLIIMEPP-MPILSYPSIKEVYLI-CNTSNLGVVAPLGYNGLL 763
QV I LIS QL +VV +++E P + P +EV + CN + ++ L YN LL
Sbjct: 61 QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLL 120
Query: 764 IMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKIITT--CFAV 819
I CT YAFKTR P NFNEAK+I FTMYTTCIIWLAF+PI++ S+Y++ TT C +V
Sbjct: 121 IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 180
Query: 820 SLSVTVALGCMFTPKMYIIIAKPERNVRS 848
SLS +V LGC+F PK++II+ +P++NV S
Sbjct: 181 SLSGSVVLGCLFAPKLHIILFQPQKNVVS 209
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 155 bits (392), Expect = 2e-37
Identities = 113/419 (26%), Positives = 199/419 (47%), Gaps = 24/419 (5%)
Query: 450 LLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVG--TWHEGVLNI 507
LL+ + K F+ + + V F++ D Y+I+ + ++ + +G TW LNI
Sbjct: 167 LLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWN-GPKWTFTVLGSSTWSPVQLNI 224
Query: 508 DDYKIQMN--KSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQ--DEFTCK 563
++ KIQ + + V +SVCS CL+G +V+ G CC+ C C ++ D + C+
Sbjct: 225 NETKIQWHGKDNQVPKSVCSSDCLEGHQRVVT-GFHHCCFECVPCGAGTFLNKSDLYRCQ 283
Query: 564 ACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVV 623
C W C P V +L S + +A + L +L+ L +F + DTPVV
Sbjct: 284 PCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVV 343
Query: 624 KSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIA 683
+S+ LC+++L + G + +PT +C L++ L L + S L ++ ++
Sbjct: 344 RSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLI 403
Query: 684 RILAGSKKKICTRKPRFMSAWAQVIIASILISV----QLTLVVTLIIMEPPMPILSYPSI 739
I K T+ P F AW Q A + + + QL + +T +++ P+P Y
Sbjct: 404 IIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRF 458
Query: 740 KEVYLI--CNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCII 797
+ ++ T++LG + YNGLL +S ++ +++P N+NEAK + F++ +
Sbjct: 459 PHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVS 518
Query: 798 WLAF---VPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTS 853
W+AF +Y G Y A S++ G F PK Y+I+ +P+ N F S
Sbjct: 519 WIAFFTTASVYDG-KYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQAS 576
Score = 39.7 bits (91), Expect = 0.013
Identities = 40/150 (26%), Positives = 66/150 (44%), Gaps = 23/150 (15%)
Query: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
Query: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
Query: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQI 183
+ VIGP S++ A LL F +P +
Sbjct: 140 --VLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 112 bits (279), Expect = 2e-24
Identities = 105/401 (26%), Positives = 179/401 (44%), Gaps = 45/401 (11%)
Query: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
Query: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
Query: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
Query: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
Query: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
Query: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
Query: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNM 427
+ K S Y A+YA+AHGL +
Sbjct: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGLHQL 403
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 55.8 bits (133), Expect = 2e-07
Identities = 71/284 (25%), Positives = 120/284 (42%), Gaps = 31/284 (10%)
Query: 595 IAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFT------- 647
I A + LG+++ + R+ ++K SS + +I+ G L Y F
Sbjct: 484 ILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSF 543
Query: 648 LIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAG--SKKKICTRKPRFMSAWA 705
+ K T C ++ ++ + + A+ KT R+ I KKKI + +
Sbjct: 544 VSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGG 603
Query: 706 QVII-ASILISVQ----LTLVVTLIIMEPPMPILSYPSIKEVYLICNTSN----LGVVAP 756
++I ILI Q L V MEP P SI+ + C ++ LG+V
Sbjct: 604 MLLIDLCILICWQAVDPLRRTVEKYSMEPD-PAGRDISIRPLLEHCENTHMTIWLGIV-- 660
Query: 757 LGYNGLLIMSCTYYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNY 810
Y GLL++ + A++TRNV PA N++KYI ++Y I+ + + F N
Sbjct: 661 YAYKGLLMLFGCFLAWETRNVSIPA-LNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNV 719
Query: 811 KIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE---RNVRSAFT 851
+ + T+ L +F PK+ + P+ +N R FT
Sbjct: 720 QFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFT 763
Score = 49.3 bits (116), Expect = 2e-05
Identities = 26/72 (36%), Positives = 40/72 (55%)
Query: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218
V G SV + LQ +++ Q++++AT+ L+DK Y YF R VPSD A+L +
Sbjct: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
Query: 219 VKRYNWTYVSAV 230
+K Y W V +
Sbjct: 190 LKHYQWKRVGTL 201
>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
Length = 1215
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/352 (21%), Positives = 135/352 (38%), Gaps = 57/352 (16%)
Query: 498 GTWHEGVLNIDDYKIQ---MNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENE 554
G +H GVL +++++ + + SG + V E ++C C+E
Sbjct: 357 GFYHPGVLPVNNFRRRGPDQHISGSTKDVSEE-----------------AYVCLPCREG- 398
Query: 555 YVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIF 614
C C AD + C +YL + I+F L +L+ L+
Sbjct: 399 -------CPFC-------ADDSPCFVQEDKYLR------LAIISFQALCMLLDFVSMLVV 438
Query: 615 VLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSA 674
+R +++S L IL G L Y L +P+T C L R L A Y
Sbjct: 439 YHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGT 498
Query: 675 LVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLV----VTLIIMEPP 730
+ K +R+ ++ + R P ++A IL+ V L+ +E
Sbjct: 499 VTLKLHRVLKVFLS---RTAQRIPYMTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEKQ 555
Query: 731 MPILSYPSIKE--VYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIA 788
+ ++ + ++ +C + + L ++ Y + R VP+ F+E +Y+A
Sbjct: 556 ISLIGQGKTSDHLIFNMCLIDRWDYMTAVA-EFLFLLWGVYLCYAVRTVPSAFHEPRYMA 614
Query: 789 FTMYTTCIIWLAFVPIYF------GSNYKIITTCFAVSLSVTVALGCMFTPK 834
++ II F I F S++ ++ L+VTV +G + PK
Sbjct: 615 VAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPK 666
>gi|7706451 G protein-coupled receptor, family C, group 5, member B
precursor [Homo sapiens]
Length = 403
Score = 52.8 bits (125), Expect = 1e-06
Identities = 51/230 (22%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 591 IESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRE----LCYIILAGIFLGYVCPF 646
I I+ A + G L+TL + LI ++ P +K ++ L ++ L G + F
Sbjct: 54 IWGIVVEAVAGAGALITLLLMLILLVR--LPFIKEKEKKSPVGLHFLFLLGTLGLFGLTF 111
Query: 647 TLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQ 706
I + T C ++R L G+ A+C+S L+++ R+ R++ R + W
Sbjct: 112 AFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLV---------RHGTGPAGWQL 162
Query: 707 VIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMS 766
V +A L+ VQ+ + V +++ +++ C + V L Y+ +L++
Sbjct: 163 VGLALCLMLVQVIIAVEWLVL---------TVLRDTRPACAYEPMDFVMALIYDMVLLVV 213
Query: 767 CTYYAFKTRNVPANFNEAK----YIAFTMYTTCIIWLAFVPIYFGSNYKI 812
A T + F K ++ T + + +IW+A++ +Y N K+
Sbjct: 214 TLGLALFT--LCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKL 261
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 10/165 (6%)
Query: 110 WHSSVALEQSIEFIRDSLISIRDE-KDGINRCLPDGQSLPPGRTKK---------PIAGV 159
W A + ++E + + S RD D + + PG+ K PI +
Sbjct: 120 WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII 179
Query: 160 IGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIV 219
+ PG SSV+ V +++++ ++Y ++S LS++ + F R PS TL + +
Sbjct: 180 LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF 239
Query: 220 KRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSN 264
+++ W ++ + S +D +E + G+ I +S+
Sbjct: 240 EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSD 284
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/312 (17%), Positives = 122/312 (39%), Gaps = 39/312 (12%)
Query: 566 DLGW-----WPNADLTGCEPIPVRYLEWSNIESIIAIA-FSCLGILVTLFVTLIFVLYRD 619
DL W W + + ++ + + + I+++ S LGI++ + V L F +Y
Sbjct: 497 DLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAV-VCLSFNIYNS 555
Query: 620 --------TPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMC 671
P + + + C + LA +F + + + C + L+GL ++
Sbjct: 556 HVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLG 615
Query: 672 YSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEP-- 729
Y ++ TK + + ++K RK + W +L+ + + + I++P
Sbjct: 616 YGSMFTKIWWVHTVFTKKEEKKEWRKT--LEPWKLYATVGLLVGMDVLTLAIWQIVDPLH 673
Query: 730 -------------PMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRN 776
+ + P ++ + LG+ GY GLL++ + A++T++
Sbjct: 674 RTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIF--YGYKGLLLLLGIFLAYETKS 731
Query: 777 VPA-NFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNYKIITTCFAVSLSVTVALGCMF 831
V N+ + + +Y ++ L P+ + A+ S + L +F
Sbjct: 732 VSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLF 791
Query: 832 TPKMYIIIAKPE 843
PKM +I + E
Sbjct: 792 VPKMRRLITRGE 803
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 10/165 (6%)
Query: 110 WHSSVALEQSIEFIRDSLISIRDE-KDGINRCLPDGQSLPPGRTKK---------PIAGV 159
W A + ++E + + S RD D + + PG+ K PI +
Sbjct: 65 WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII 124
Query: 160 IGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIV 219
+ PG SSV+ V +++++ ++Y ++S LS++ + F R PS TL + +
Sbjct: 125 LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF 184
Query: 220 KRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSN 264
+++ W ++ + S +D +E + G+ I +S+
Sbjct: 185 EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSD 229
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/312 (17%), Positives = 122/312 (39%), Gaps = 39/312 (12%)
Query: 566 DLGW-----WPNADLTGCEPIPVRYLEWSNIESIIAIA-FSCLGILVTLFVTLIFVLYRD 619
DL W W + + ++ + + + I+++ S LGI++ + V L F +Y
Sbjct: 442 DLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAV-VCLSFNIYNS 500
Query: 620 --------TPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMC 671
P + + + C + LA +F + + + C + L+GL ++
Sbjct: 501 HVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLG 560
Query: 672 YSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEP-- 729
Y ++ TK + + ++K RK + W +L+ + + + I++P
Sbjct: 561 YGSMFTKIWWVHTVFTKKEEKKEWRKT--LEPWKLYATVGLLVGMDVLTLAIWQIVDPLH 618
Query: 730 -------------PMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRN 776
+ + P ++ + LG+ GY GLL++ + A++T++
Sbjct: 619 RTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIF--YGYKGLLLLLGIFLAYETKS 676
Query: 777 VPA-NFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNYKIITTCFAVSLSVTVALGCMF 831
V N+ + + +Y ++ L P+ + A+ S + L +F
Sbjct: 677 VSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLF 736
Query: 832 TPKMYIIIAKPE 843
PKM +I + E
Sbjct: 737 VPKMRRLITRGE 748
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 10/165 (6%)
Query: 110 WHSSVALEQSIEFIRDSLISIRDE-KDGINRCLPDGQSLPPGRTKK---------PIAGV 159
W A + ++E + + S RD D + + PG+ K PI +
Sbjct: 182 WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII 241
Query: 160 IGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIV 219
+ PG SSV+ V +++++ ++Y ++S LS++ + F R PS TL + +
Sbjct: 242 LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF 301
Query: 220 KRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSN 264
+++ W ++ + S +D +E + G+ I +S+
Sbjct: 302 EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSD 346
Score = 41.6 bits (96), Expect = 0.003
Identities = 56/312 (17%), Positives = 122/312 (39%), Gaps = 39/312 (12%)
Query: 566 DLGW-----WPNADLTGCEPIPVRYLEWSNIESIIAIA-FSCLGILVTLFVTLIFVLYRD 619
DL W W + + ++ + + + I+++ S LGI++ + V L F +Y
Sbjct: 559 DLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAV-VCLSFNIYNS 617
Query: 620 --------TPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMC 671
P + + + C + LA +F + + + C + L+GL ++
Sbjct: 618 HVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLG 677
Query: 672 YSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEP-- 729
Y ++ TK + + ++K RK + W +L+ + + + I++P
Sbjct: 678 YGSMFTKIWWVHTVFTKKEEKKEWRKT--LEPWKLYATVGLLVGMDVLTLAIWQIVDPLH 735
Query: 730 -------------PMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRN 776
+ + P ++ + LG+ GY GLL++ + A++T++
Sbjct: 736 RTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIF--YGYKGLLLLLGIFLAYETKS 793
Query: 777 VPA-NFNEAKYIAFTMYTTCIIWLAFVPIYF----GSNYKIITTCFAVSLSVTVALGCMF 831
V N+ + + +Y ++ L P+ + A+ S + L +F
Sbjct: 794 VSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLF 853
Query: 832 TPKMYIIIAKPE 843
PKM +I + E
Sbjct: 854 VPKMRRLITRGE 865
>gi|93352554 GPR158-like 1 [Homo sapiens]
Length = 2367
Score = 47.4 bits (111), Expect = 6e-05
Identities = 64/315 (20%), Positives = 115/315 (36%), Gaps = 28/315 (8%)
Query: 562 CKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTP 621
C C G D T C +E + + +A +L L+ R
Sbjct: 356 CLPCPEGCTSCMDATPC------LVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRRNK 409
Query: 622 VVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNR 681
+ +S L +L G L Y F L KP+ C R + L A+ Y ++ K R
Sbjct: 410 RIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKLYR 469
Query: 682 IARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLI------IMEPPMPILS 735
+ ++ + R S + +L+ V L V + I P+ I
Sbjct: 470 VLQLFLS---RTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVIRG 526
Query: 736 YPSIKEVYLICNTSN---LGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792
+ + +C+ + VVA L LL+ ++ + TR V + F+E +Y+ ++
Sbjct: 527 HTPSGRHFYLCHHDRWDYIMVVAEL----LLLCWGSFLCYATRAVLSAFHEPRYMGIALH 582
Query: 793 TTCIIWLAFVPIYF------GSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
++ AF F ++ ++ F +VT L +F PK + + A P +
Sbjct: 583 NELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREEM 642
Query: 847 RSAFTTSDVVRMHVG 861
++ H G
Sbjct: 643 VDEVCEDELDLQHSG 657
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/157 (22%), Positives = 70/157 (44%), Gaps = 8/157 (5%)
Query: 156 IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAM 215
+A + GP SS VQ++ ++P I + +K L+ ++ + P +RA+
Sbjct: 104 VAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF--YINLYPDYAAISRAI 161
Query: 216 LDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLR 275
LD+V YNW V+ V+ + +G+ +EL +G K LL+
Sbjct: 162 LDLVLYYNWKTVTVVYED----STGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK 217
Query: 276 KLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEF 312
++++ K V+ C T +L + +G++ E+
Sbjct: 218 EMKK--GKEFYVIFDCSHETAAEILKQILFMGMMTEY 252
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/157 (22%), Positives = 70/157 (44%), Gaps = 8/157 (5%)
Query: 156 IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAM 215
+A + GP SS VQ++ ++P I + +K L+ ++ + P +RA+
Sbjct: 104 VAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF--YINLYPDYAAISRAI 161
Query: 216 LDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLR 275
LD+V YNW V+ V+ + +G+ +EL +G K LL+
Sbjct: 162 LDLVLYYNWKTVTVVYED----STGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK 217
Query: 276 KLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEF 312
++++ K V+ C T +L + +G++ E+
Sbjct: 218 EMKK--GKEFYVIFDCSHETAAEILKQILFMGMMTEY 252
>gi|4505441 natriuretic peptide receptor C/guanylate cyclase C
(atrionatriuretic peptide receptor C) [Homo sapiens]
Length = 540
Score = 43.5 bits (101), Expect = 9e-04
Identities = 77/384 (20%), Positives = 144/384 (37%), Gaps = 55/384 (14%)
Query: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDK-TLYKYFLRVVPSDTLQARAMLD 217
++GP A V L +D+P ++ A + K + Y + RV P+ ML
Sbjct: 131 ILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLA 190
Query: 218 IVKRYNWTYVSAVHTEGNYGES---GMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLL 274
+ + ++W+ + V+++ + ++ E+ +EGL IYS K D L
Sbjct: 191 LFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGL----HTSIYSFDETKDLD-LE 245
Query: 275 RKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVV-GEFSLIGSDGWADRDEVIEGYEVE 333
+R RVV+ T+R ++ R G+ G+++ IE +
Sbjct: 246 DIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFN----------IELFNSS 295
Query: 334 ANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRI 393
+ G + K + L+ T R PEF + + + +E
Sbjct: 296 SYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTV-KPEFEKFSMEVK---SSVEKQGLNM- 350
Query: 394 CTGNESLEENYVQDSKMGF-VINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLD 452
E+YV GF +Y +A +H L G+ DG K++
Sbjct: 351 --------EDYVNMFVEGFHDAILLYVLA-----LHEVLRAGY-------SKKDGGKIIQ 390
Query: 453 FLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNI----- 507
+F G++G +V D GD G + ++ + EA + + EG +
Sbjct: 391 QTWNRTFEGIAG-QVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVK 449
Query: 508 ---DDYKIQMNKSGVVRSVCSEPC 528
K++++++ +V S PC
Sbjct: 450 YPWGPLKLRIDENRIVEHTNSSPC 473
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,032,425
Number of Sequences: 37866
Number of extensions: 1511397
Number of successful extensions: 3181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2997
Number of HSP's gapped (non-prelim): 86
length of query: 906
length of database: 18,247,518
effective HSP length: 111
effective length of query: 795
effective length of database: 14,044,392
effective search space: 11165291640
effective search space used: 11165291640
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.